Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Esmer, Yusuf(28)
- Battal, Fetullah(27)
- Öztürk, Mesut(22)
- Ayata, Ümit(21)
- Korkmaz, Özge(18)
- Bayraktar, Bülent(17)
- Maden, Sedat(17)
- Ustabulut, Mete Yusuf(16)
- Degirmenci, Yavuz(15)
- Ag, Aliriza(14)
- Bulut, Mehmet(14)
- Göktaş, Bora(14)
- Pabuçcu, Hakan(14)
- Apak, Ömer Ceyhun(13)
- Dayı, Özkan(13)
- Güzel, Ferdi(13)
- Kaplan, Kadir(13)
- Yıldız, Şaduman(13)
- Arslaner, Ayla(12)
- Durmuş, İbrahim(12)
- Gıdık, Betül(12)
- Kan, Muhammed Enes(12)
- Kul, Murat(12)
- Küçük Demir, Betül(12)
- Semerci, Vahide(12)
- Bayramoglu, Turgut(11)
- Dursunoğlu, İsmail(11)
- Kuzu, Mehmet(11)
- Kırbaş, Zila Özlem(11)
- Sefali, Abdurrahman(11)
- Sönmez Sarı, Ebru(11)
- Tosun, Figen Çam(11)
- Akeren, Zahide(10)
- Bulut, Ayhan(10)
- Doğan, Zeki(10)
- Filiz, Tunahan(10)
- Gül, Volkan(10)
- Gültekin, Ömer Faruk(10)
- Imamoglu, Ilyas Kays(10)
- Kahya, Cem(10)
Yayınlar
- MakaleAçık Erişim2021The Adaptation of the Connor‒Davidson Resilience Scale Short Forminto Turkish: A Validity and Reliability Study
Kaya, Feridun; Odaci, Hatice
The aim of this research is to adapt the Connor-Davidson Resilience Scale Short Form (CDRSSF) into Turkish and perform validity and reliability studies on it. The research group comprised 1211 university students. Data collection tools included the CDRSSF, CES Depression Scale, Self-Esteem Scale, and Perceived Stress Scale. The exploratory factor analysis results revealed that the scale has a single-factor structure. A confirmatory factor analysis was completed to confirm the structure determined by the exploratory factor analysis. The same appeared to confirm this structure. A correlation analysis results was performed to identify the criteria-dependent validity in the research. The results show a negative correlation between the psychological resilience levels of university students with perceived stress and depression levels. However, there was a positive correlation observed between psychological resilience with self-esteem. The internal consistency coefficient was found to be 0.81 within the scope of reliability studies for the scale. Two half-test correlations of the scale was documented as 0.78. The results of the research show that the CDRSSF is a valid and reliable measurement device to measure the psychological resilience of university students.
AtıfOpenAlex44TR Dizin8
İncele - MakaleAçık Erişim2021Üniversite Öğrencilerinin Kurumsal İmaj Algıları: Bayburt Üniversitesi Örneği
Kömür, Gökhan
Bu çalışmanın amacı üniversite öğrencilerinin fikirlerini alarak bir devlet üniversitesinin kurum imajını tespit etmektir. Bu bağlamda Türkiye’nin en genç üniversitelerinden biri olan ve Türkiye’nin en küçük ilinde kurulan Bayburt Üniversitesi’nin öğrencileri araştırmaya konu edinilmiştir. Bu amaç kapsamında imaj oluşumunu etkileyen unsurlar değerlendirilerek kurum imajı yedi farklı grup soru oluşturularak incelenmiştir. Demografik özellikler, bakış açısı, destek, bağlılık, iletişim, tatmin, hizmet gibi algıları ölçen sorularla üniversite öğrencilerinin üniversite ve üniversite yönetimi hakkındaki algıları incelenmiştir. Çalışmanın amaçlarına, araştırma sorularına ve hipotezlerine uygun olarak, tanımlayıcı araştırma yöntemi benimsenmiş ve belirlenen değişkenler ile aralarındaki ilişkilerin birincil veriler kullanılarak ölçümüne karar verilmiştir. Bu araştırmada birincil yöntem olarak Lale Örer’in (2006) Kahramanmaraş Sütçü İmam Üniversitesi’nin Kurumsal İmajının Öğrenciler Açısından Ölçülmesi Üzerine Bir Alan Çalışması adlı araştırmasında kullanılan ölçekten faydalanılmıştır. Araştırma sonuçlarına göre Üniversitesi’nin kurumsal imajının ‘‘orta düzey’’ de olduğu tespit edilmiştir. Öğrencilerin imaj algılarında fakülte ve yüksekokul değişkenine göre anlamlı düzeyde bir farklılık olmadığı, fakat cinsiyet, üniversite hakkında ön bilgi ve öğrencinin okuduğu sınıf değişkenlerine göre anlamlı düzeyde farklılık gösterdiği tespit edilmiştir.
- MakaleAçık Erişim2021Islamic philosophy in arts and an example of its application
Katiranci, Meltem; Tümer Çelik, Yasemin
The research entitled ‘Islamic philosophy in arts and an example of its application' looks into vahdet-i vücut, which is one of the topics of mysticism and sabit öz. It also discusses how these topics are reflected in arts.“vahdeti vücut” and “ayan-i sabite”. which are included in Islamic philosophy are found useful because of their relation to arts and the philosophical content they have. When the broad perspective that philosophy offers to human is considered, one can understand that philosophy has a big role in İslam, which takes a deep philosophical approach.In the philosophy and art of İslam, spiritual feeling and orientation to the soul are prominent. In the fıeld of art, spiritual feelings are utilized. The researcher thınks that because these topics are related to our culture and important in Islamic philosophy, student artists should know and leam about these as a part of their curriculum. Research:achievement test from quantiative methotds, pre-final Picture evaluation and qualitative. The metod is completed with the evaluation of the pre-final text. Success in the finding section test, differences between age, gender, class and universities were evaluated. Pre- end creativity and philosophical explanations of students with pictures and pre-final text. It was evaluated.
- MakaleAçık Erişim2021Determination of Physicochemical Properties, Powder Flow Behavior and Particle Size Parameters of Goat Milk Powders with Different Fat Content
Sert, Durmuş; Mercan, Emin
In this study, the effects of different fat ratios on some physicochemical properties, powder flow behavior (caking, cohesion and powder flow speed dependent properties) and particle size of goat milk powder were investigated. For this purpose, skim (SMP) and whole goat milk powders (WMP) were produced by spray-drying method. The tapped bulk density was determined as 0.71 g cm-3 in the SMP and 0.57 g cm-3 in the WMP. The solubility in both samples was 99.80%. The caking strength of SMP (-0.190 N.mm) was found to be significantly low compared to that of WMP (26.734 N.mm). The cohesion index of SMP was found to be 21.7, and that of the WMP was 42.2. Depending on the increasing speed, cohesion index values were found to be lower in SMP compared WMP. In both samples the compression coefficients decreased with increasing speed. At a speed of 100 mm s-1 , the compression coefficient of SMP was 38.6 N.mm, while this value was 63.3 N.mm for WMP. The D[4,3] value was determined as 44.0 µm in SMP and 34.2 µm in WMP. The results of powder flow analysed revealed that crucial data on the flow behavior of goat milk powder.
AtıfTR Dizin1İncele - MakaleAçık Erişim2021Investigation pre-service turkish language teachers’ curiosity and exploring levels in terms of some variables
Ustabulut, Mete Yusuf
This research is aiming to analyze the curiosity and the level of exploring and the changing effects of this level for the pre-service Turkish language teachers. Survey model, which is one of the quantitative research designs, was used in the research. Target population of the research constitutes the students from the Department of Turkish Education in University of Bayburt. As data collection tool Curiosity and Exploring Scope II and to determine the socio-demographic quality of the students Personal Information Form (PIF) was used. Data of the research were collected online on a voluntary basis. Inferential quantitative statistics were used in the analysis of the data. Since the data set, which was acquired in the survey, didn’t ensure normal distribution nonparametric tests Whitney U and Kruskal Wallis were used in the in the analysis of data. In the consequence of the survey curiosity and level of exploring of the pre-service teachers weren’t discovered any differences according to their genders, class grades, ages, and education level of their parents, income level of their families and geographical area they live in.
AtıfOpenAlex1TR Dizin1İncele - MakaleAçık Erişim2021Moğol asrında basra körfezi (1220-1335)
Dayı, Özkan
Moğolların İran coğrafyasına hâkim olması ile Güney İran bölgesinde bulunan yönetimlerin elinde bulunan Basra Körfezi’nin ticaret merkezleri de dolaylı olarak daha sonra İlhanlı Devleti’nin denetimine girmişti. Basra körfezi ticareti XIII. yüzyılda İlhanlı Devleti’nin önemli ticaret güzergâhlarından biri idi. Basra körfezi üzerinden yapılan ticaret, Umman ve Hind denizleri vasıtası ile baharat yolu ticarteinin önemli duraklarına ulamaktaydı. Basra körfezi vasıtası ile İlhanlılar, Arabistan, Hindistan, Çin ve Güneydoğu Asya diyarlarından getirilen kıymetli malları Avrupa’ya ulaştırmakta idiler. İlhanlılar zamanında oldukça zengin bir ticarî hayata sahip olan Basra körfezi, İlhanlı Devleti’nin iktisadî yapısının da önemli dayanaklarından birisi idi. Bu bağlamda Ortaçağ ticarî faaliyetlerinde değerli bir yeri olan Basra körfezi’ni ve bu körfezin komşu olduğu Umman ve Hind Denizi ticarî güzergâhını, bu bölgenin önemli ticaret limanlarını bu coğrafyada İlhanlı Devleti’nin hâkimiyeti sürecinde değerlendireceğiz. Basra körfezi civarında bulunan ve bu bölgenin ticaret limanlarını ellerinde bulunduran, İlhnalılara tabi yerel yönetimlerin İlhanlılar ile ilişkileri ve bu ilişkinin Basra körfezi ticaretne yansıması çalışmamızda ele alamaya gayret edeceğimiz bir diğre husus olacaktır.
AtıfOpenAlex1İncele - MakaleYalnız künye2021Suppression of the Anabaptists Forcing Luther to Social and Political Reform
Keleş, Hatice
The Reformation movement that emerged in the 16th century is seen as the success of Martin Luther, who tried to establish his own authority against the authority of the Pope and the clergy. However, although the reform movement was the success of Luther, it did not progress as he wanted, and while Luther wanted to realize his reform in line with his aims, this reform led to the emergence of different groups in addition to the Catholic Church against Luther. The Reformation also encouraged and guided some clergy who had questions about the Catholic world and Bible practices. Thus, in that era, the diversity and differentiation in the ways of religious thought and perception led to the emergence of many different groups. One of these groups was named Anabaptist because they claimed that adult baptism is true baptism, and they went down in history as the "Radical Movement" due to these contrary beliefs. In this research, we tried to cover some of the heated debates between the Anabaptist leaders and Luther, Luther's attitude towards them, and partly the Peasants' War.
AtıfTR Dizin1İncele - MakaleAçık Erişim2021Feasible Waveguide Method for Obtaining ElectromagneticProperties of Biaxial Bianisotropic Materials with Strong Magneto Electric Coupling
Kaya, Yunus
In this study, an easy-to-apply waveguide method is proposed for material characterization of biaxial bianisotropic samples withstrong magneto-electric coupling. Its underlying expressions are derived considering scattering (S-) parameters of the sample at onefixed orientation in two waveguides at their dominant modes with different cross sections. The method is validated by synthesized andretrieved electromagnetic properties of a sample when there is no/some noise.
- MakaleAçık Erişim2021Yabani Kara Kuşburnu (R. pimpinellifolia L.) Meyvesinin Mineral İçerik ve Biyoaktif Bileşenler Açısından Değerlendirilmesi
Çakır, Özlem; Ergen, Berivan
Bu çalışmada Bayburt ilinde doğal olarak yetişen yabani R. pimpinellifolia L. meyvesinin genel özellikleri araştırılmıştır. Bu meyveninantioksidan özellikleri dört farklı yöntem (DPPH, ABTS, CUPRAC ve β-karoten ağartma) kullanılarak hem su hem de metanolekstrelerinde belirlenmiştir. Toplam fenolik madde içeriği ve fenolik profili sırası ile FCR (Folin-Ciocalteu ayıracı) metodu ve HPLCyardımıyla analiz edilmiştir. Bunlara ilaveten mineral madde içeriği ve bazı fizikokimyasal özellikleri ele alınmıştır. Su ekstresindemeyve antioksidan seviyeleri CUPRAC yönteminde 0.56 mmol TR/g-örnek, β-karoten ağartma yönteminde %97.02, ABTS metodunda%88.65 ve DPPH metodunda ise %86.69 olarak tespit edilmiştir. Metanol ekstresinde ise CUPRAC yönteminde 0.99 mmol TR/g-örnek,β-karoten yönteminde %95.21, ABTS metodunda %93.43 ve DPPH metodunda ise %85.21 olarak tespit edilmiştir. Toplam fenolikbileşen seviyesi ise sulu ekstresinde 929.27 mg GAE/100g olarak belirlenmiş olup bu değer metanol ekstresinde elde edilendenyüksektir. Meyvenin içerdiği fenolik bileşenler arasında en baskın olanların sırası ile klorojenik asit, vanilik asit ve gallik asit olduğubelirlenmiştir. Meyvede bulunan minerallerin arasında en yoğun olanlar sırası ile K (12.1688 mg/ml), P (1.3429 mg/ml) ve Mg (1.1926mg/ml) olurken en az bulunan mineralin ise Cr (0.00001 mg/ml) olduğu açığa çıkartılmıştır. Sonuç olarak kara kuşburnu meyvesinin(R. pimpinellifolia) sahip olduğu bu özelliklerden dolayı çok iyi bir doğal besin olarak değerlendirilebileceği anlaşılmıştır.
AtıfOpenAlex3TR Dizin2İncele - MakaleAçık Erişim2021The Effect of Using Different Exhaustion Intervals and Mathematical Models on Critical Power Estimations
Balcı, Görkem Aybars; Ozkaya, Ozgur; Norouzi, Mahdi; Çabuk, Refık; As, Hakan
Predicted critical power (CP) varies up to 5-20% depending on the preferred mathematical model and different time to exhaustion intervals. Those differentiation rates related to CP estimations cause some contradictory results. The aim of this study was to evaluate the relationship between CP predictions obtained from three different exhaustion approaches (short: 2-10 minutes; medium: 2-15 minutes; long: 2-20 minutes) using five mathematical models (linear total work (CP1), linear 1/time (CP2), nonlinear 2-parameter (CP3), nonlinear 3-parameter (CP4) and exponential (CP5)), and other indices such as maximal lactate steady-state (MLSS), ventilatory threshold (VT), respiratory compensation point (RCP) and critical threshold (CT). 10 well trained male cyclists voluntarily participated in the study. VT and RCP levels of the athletes were determined by incremental ramp tests. Constant work rate exercises were applied on different days to determine maximal oxygen uptake, peak power output, MLSS, CT and CP. Obtained data were tested by validity analysis. As mathematical models and exhaustion intervals changed, the CP predictions varied up to 20%. Except the CP4, other CP estimations were higher than the work rates corresponding to the MLSS and VT (p<0.05). The CP5, which was estimated by short exhaustion interval, corresponded to the work rates belonging to the CT and RCP (p>0.05; standard error of estimate ~4% and r>0.95). Regardless of the preferred exhaustion interval, CP predictions obtained from the other mathematical models were insufficient to estimate any of anaerobic threshold indices (p<0.05). As a result, the CP5 estimated by short exhaustion interval can be used to predict the work rates corresponded to the CT and RCP. It was not appropriate to estimate the other threshold intensities by the CP.
AtıfOpenAlex2TR Dizin1İncele - MakaleAçık Erişim2021Improving of Lightweight Concrete Properties Produced with Pumice Aggregate of Nevşehir Region with Fly Ash Substitution
Apay, Ahmet Celal; Çaglar, Hakan; Çimen, Selçuk; Çağlar, Arzu; Kale, Mehmet Oğuzhan
In this study, it was aimed to determine the effects of industrial waste fly ash substitution on physical and mechanical properties of lightweight concrete. In this respect, lightweight concrete samples were produced by the use of fly ash as a cement replacement material in different proportions (1%, 3% and 5%). In lightweight concrete production, the Nevşehir region acidic pumice has been used as aggregate. The physical and mechanical properties of these lightweight concrete samples were investigated and microstructural analysis was carried out. To determine the physical differences, dry unit volume weight, capillary water absorption, porosity, compactness and freezethaw experiments were conducted. For the determination of mechanical properties, tensile splitting strength and compressive strength tests were applied. SEM images have been interpreted to examine the structural differences occurring within the material. As a result of the study, it was determined that the physical and mechanical properties of the ligtweight concrete were improved with the increase in the amount of fly ash. The best results were obtained from sample with 5% fly ash substitution. The use of industrial waste in a large sector such as construction, which adversely affects the ecological balance, will be an opportunity to dispose of waste.
AtıfOpenAlex7İncele - MakaleAçık Erişim2021Social Construction of Academy, Classities and Social Prospects: The Case of Bayburt University
Özkurt, Cem
This article aims to explore the sociological rhythms of our academic world and tounderstand the dynamics of our academic culture. In this context, in-depth interviews wereconducted with 30 academics from Bayburt University academic staff and data from aqualitative study was collected. In the conceptual framework of the study, the analysis ofcommentators such as Bourdieu, Freire and Apple who developed a theoretical approach tothe educational problem was used. The study aims to describe our academic reality with aninsider's view of the professional practices of academics, the processes of cognitive andemotional construction in the periods before academia, and the world of meaning that actorsattribute to the profession of academia. In the study, the reflections of our university structureon micro-worlds were tried to be portrayed with their authentic integrity and banality/as it isthrough the eyes of academic failure. The contribution of the study to the literature is toidentify the problem areas of our academic reality at both the structure and level of activityand to start a discussion within the framework of solution proposals.
AtıfOpenAlex2TR Dizin1İncele - MakaleAçık Erişim2021A different conceptual relationship in the language - sense systems: the principle of directionality in the sample of old turkic
Azili, Kenan
The fact of "existing in space", which is placed on the basis of human existence and sense systems, shows its effect in various forms that compose language systems. Being in the space also requires the use of various attributes of the space in thought systems; accordingly, it causes the forms of expression to occur according to spatial characteristics and to be directly dependent on the space. This result, which brings together some kind of physics and metaphor systems, has many traces on languages. Six directions such as forward/backward, down/up and right/left in the horizontal, vertical and lateral dimensions of the space organize logical relations in many linguistic fields, from grammar and word derivations to different morphological and syntactic strategies in some language units. It is understood that most of the language forms identified in the modern and historical language periods are derived from the root forms related to the above directions and it shows some metaphorical and conceptual developments. These occur within the framework of some principles that can be described as the “the principle of directionality” in the literature. In this study, various forms that developed depending on the directionality and their conceptual relations in Old Turkic, the first written period in which the development of Turkic was followed from various aspects, will be evaluated. The results of the principle of directionality, which have been put forward based on various previous studies, will be discussed and the strategies of Turkic based on the principle of directionality will be examined theoretically.
AtıfTR Dizin1İncele - MakaleYalnız künye2021Scopus SJRQ3Orta Asya Türk Cumhuriyetleri ile Türkiye Arasında Sosyal Güvence İş Birliklerinin Değerlendirilmesi
Bulut, Mehmet
Uluslararası göçün göçmenler açısından ortaya çıkardığı en önem- li sorunlardan birisi sosyal güvence konusudur. Nitekim ülkelerin- den yurtdışına çalışmaya giden kişiler sosyal güvenlik mevzuatla- rındaki katı kuralların etkisi ile ya tamamen sistem dışında kalmış ya da her iki ülke sisteminin de parçası olmuşlardır. Bu sorunun çözümlenmesi açısından ülkeler iç hukuk sistemlerinin yanında ikili sosyal güvenlik sözleşmelerini devreye sokmaktadırlar. Tür- kiye ile Orta Asya Türk Cumhuriyetleri arasında yaşanan insan hareketliliği de yıllar içinde kümülatif olarak artmıştır. Bunun so- nucunda gerçekleşmesi gereken sosyal güvence iş birliği ise henüz yeterli seviyede değildir ve bazı adımların atılması gerekmektedir. Mevcut durumda Azerbaycan ve Kırgızistan ile onaylanmış olan ikili sosyal güvenlik sözleşmeleri bulunmaktadır. Ancak uygulama noktasında sıkıntılar yaşanmaktadır.
- MakaleAçık Erişim2021Non-Urbanization and Social Dynamics of Violence against Women
Alacadağlı, Esmeray
Urbanization is a concept that defines the increase in the population living in cities in terms of demographics. In Turkey, the number of individuals living in urban areas increased continuously after the 1950s and reached around 93% as of today. However, urbanization also has economic and social dimensions. Because, rapidly increasing urbanization without sufficient infrastructure and demand generally leads to formation of cities with underlying unemployment, and the emergence of a social structure that is urbanized but not localized, ultimately not being able to integrate with the city. Generally, this social segment tries to survive by settling in the urban suburbs, consists largely of the masses who are not able earn their living with urban-jobs, and who ultimately cannot adopt urbanspecific behaviors, lifestyles and values. Hence, these masses try to survive in the city and with the dominant values of the places they came from, instead of integrating to the city culture, which leads to their alienation to city values, resulting alienation and potential tendencies towards violence due to increasing marginalization.This literature review-based study aims to provide solutions by analyzing the causes of the violence against women, which has recently been increased in our society, in the context of migration, urbanization and poverty phenomenon. Research results reveal the importance of nonurbanization and poverty, as being factors for violence against women.
AtıfOpenAlex1TR Dizin2İncele - MakaleAçık Erişim2021Causality Relationship Between Government Stability and Trade Openness: The Case of Turkey
Arı, Ari
International trade is very exposed to political risk and the existence of political risk components in a given market may cause problems in both export and import activities. Government instability is one of the political risk components that is related with trade openness. The paper examines the government stability-trade openness nexus for Turkey using Vector Error Correction Model (VECM) and VECM based Granger Causality test covering the period of 1984-2016. Results have shown that there is a unidirectional causality in the long run from trade openness to government stability. Because Turkey’s production of final goods usually is based on imports, an increase in exchange rate usually floats trade openness in favor of imports. This creates foreign trade deficit. Worsening economic conditions affects the government stability. Due to the unfavorable picture and economic crises in Turkey, the average duty time of the governments established between 1990-2003 was one year. Despite this, export-led growth and highest amount of foreign direct investment within three election periods starting from 2002, enabled the individuals to grasp the importance of stability in governance. During the 2010s, Turkey struggled with the foreign trade deficit, high inflation and unemployment rates brought about by the high exchange rate, and the deteriorating economic situation caused the ministers in the cabinet and even the presidential system to change. Thus, the study concluded that trade openness may affect the policy-relevant implications and create government instability for Turkey through changes in exchange rates and depreciation of Turkish lira.
AtıfOpenAlex3TR Dizin1İncele - MakaleAçık Erişim2021Does the inclusion of women on the board add profit and value added to firms?
Ag, Aliriza; Yilmaz, Tuncer; Zengin, Yunus
Based on the idea that the majority of family companies and the dominance of patriarchy in the social structure in Turkey may reduce the effectiveness of female managers in company management, this study aims to examine the effect of female managers on firm performance in Borsa Istanbul (BIST) companies. We limited our study to 126 manufacturing companies that were continuously traded in the BIST in the 2010- 2017 periods. In general, the following results were obtained in the multiple regression analyzes. The ratio of women in the board of directors and the presence of at least 1 woman in the board of directors were not found to have a significant effect on performance criteria. While the effect of having 2 or more women in the board of directors on ROE and having 3 or more women on EVA/TA was significant, the effects on other performance criteria were not found to be significant.
- MakaleYalnız künye2021Baku state university: the foundation adventure of the first european-style higher education institution of the east
Sadık, Ramin
The Republic of Azerbaijan, which was founded on May 28, 1918 and lived for only twenty three months, took important steps in public education. Among these steps, nationalization of schools, the use of Azerbaijani Turkish in official correspondence, the invitation of instructors from the Ottoman Empire and the writing of new curriculum were the most significant. Apart from these, the decisive move of the government was opening of a European-style public university for the first time among Muslim states in the Eastern world. The intellectuals of the period who succeeded in opening a State University in Baku in November 1919 showed that they had a broad vision for education and development of the country. Therefore, the university was considered as an important gift to the people of Azerbaijan. In this study, the establishment process of Baku University is discussed. The historical adventure related to the process was explained by the fact that despite scarcity in financial resources, the lack of scientists and students, debates and controversies occurred. This paper deals with the nature of these debates regarding the university project in the Azerbaijan Parliament. The archival sources, articles in the press and research works were examined and the subject was discussed in an original and objective manner.
AtıfOpenAlex2TR Dizin2İncele - MakaleAçık Erişim2021L929 Hücre Hattında Lipopolisakkaritle İndüklenen Sitotoksisite Modeli Üzerine Ferulago pauciradiata Boiss. & Heldr. Bitkisinin Kökünden İzole Edilen Prantşimgin Bileşiğinin Etkisinin İncelenmesi
Karabulut, Sevgi; Karakaya, Songül; Kutlu, Zerrin; Postallı, Fatma Gül Delimustafaoğlu
L929 hücre hattında oluşturulan lipopolisakkarit (LPS) kaynaklı sitotoksisite modelinde Ferulago pauciradiata (Apiaceae) bitkisinin kök kısmından izole edilen prantşimgin (Prn) bileşiğinin etkisinin incelenmesi. L929 hücre hatları, 37°C'de %5 CO2'li inkübatörde standart hücre kültürü prosedürleri kullanılarak son konsantrasyonu 2 µL olacak şekilde Prn saf maddesi ve 1 saat sonra son konsantrasyonu 1 µL olacak şekilde LPS uygulandı. LPS uygulamasının ardından, gerekli olan 24, 48 ve 72 saat inkübasyon süreleri sonunda sitotoksik etkilerin belirlenmesi amacıyla kolorimetrik bir metot olan MTT protokolü uygulandı. IC50 değerleri, Prn için 0.28 µg/mL ve LPS için ise 1 µg/mL olarak hesaplandı. L929 hücre hatlarına LPS uygulanmasının zamana bağlı olarak hücresel indekste anlamlı derecede azalmaya neden olmuştur. Ayrıca Prn+LPS gruplarında ise sadece LPS uygulanan grubuna göre azalmış hücre indeksini, anlamlı derecede artırdığı hatta kontrole yaklaştırdığı tespit edilmiştir.L929 hücre hattına uygulana LPS ile oluşturulan sitotoksisite ve hücre hasarını Pnr uygulaması sonucunda düzeldiği tespit edildi.
AtıfOpenAlex2İncele - MakaleAçık Erişim2021Ürkiye’de Bilgi ve İletişim Teknolojileri (BİT), Uluslararası Göç ve Ekonomik Büyüme Arasındaki İlişki
Arı, Ari
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