Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2026Tıp Fakültesi Öğrencilerinde Sınav Kaygısının Fizyolojik Belirtilerini Azaltmada Ardıç ve Kekik Uçucu Yağlarının Etkinliği
Erkılıç, Tugçe Orkun; Bayraktar, Bülent; Bozok, Ümmü Gülşen; Ozcan, Gulbahar Boyuk
Tıp öğrencileri, bilişsel ve akademik performansı olumsuz etkileyen sınav kaygısıyla mücadele etmektedir. Aromaterapi, farmakolojik tedavilere alternatif olarak popüler hale gelmektedir. Bu çalışma, ardıç ve kekik esansiyel yağlarının lisans öğrencilerinin sınav kaygısını psikofizyolojik olarak nasıl etkilediğini incelemektedir. Sınavlara giren öğrencilerde ardıç ve kekik aroması inhalasyonu asprosin, siklik guanozin monofosfat yanıt elementi bağlayıcı protein (CREB), kortizol ve sınav kaygısı üzerinde test edilmiştir. Yöntem: Tıp Fakültesi'nden 18-25 yaş arası 80 sağlıklı öğrencinin rastgele bir örneği, final sınavları sırasında toplanmıştır. Katılımcılar kendi kontrolleriydi ve aromaterapiden önce ve sonra tükürük alındı. Tükürük örnekleri ELISA kullanılarak Asprosin, CREB ve kortizol için test edildi. Kalp hızı, oksijen satürasyonu, sistolik basınç, diyastolik basınç ve vücut sıcaklığı aroma inhalasyonundan önce ve sonra izlenmiştir. Bulgular: Bu çalışmanın bulgularına göre, ardıç ve kekik aromaterapisinin tükürük ortalama Asprosin, CREB ve kortizol hormon düzeylerini artırmada etkili olduğu, en anlamlı düşüşün ise ardıç aromaterapisi alan gruplarda olduğu tespit edildi (p<0.001). Ardıç aromaterapi uygulaması Sistolik Kan Basıncı (SKB) ve Diyastolik Kan Basıncı (DKB)'yi etkilemiş (p<0.05) ancak Kalp Atım Hızı (KAH), Periferik Kapiller Oksijen Satürasyonu (SPO2) veya sıcaklığı etkilememiştir (p>0.05). Kekik aromaterapisi SBP, DBP, HR, SPO2 veya sıcaklığı etkilememiştir (p>0.05). Sonuç: Hafıza ve duyguları kontrol eden limbik sistem koku ile bağlantılıdır. Çalışmamız, koku inhalasyonunun sınav sırasında üniversite öğrencilerinde Asprosin, CREB, kortizol ve diğer fizyolojik göstergeleri etkilediğine dair özgün kanıtlar ortaya koymuştur ve sınav kaygısının giderilmesinde destekleyici bulgular sunmaktadır.
AtıfOpenAlex2
İncele - MakaleAçık Erişim2026Investigation of Managerial Practices Related to Calves’ Survival in Dairy Cattle Farms: The Case of Çorum Province
Bayraktar, Bülent; Tekce, Emre; Aydemir, Seyma; Erdoğan, Yaşar; Aksakal, Vecihi; Ürüsan, Hılal; Kotan, Gökşad Cemil
This study was conducted using a Cross-Sectional Observational Design to determine the effects of current managerial practices applied in commercial dairy cattle farms in Çorum Province on calf survival. The main material of the study consisted of 120 active farms, which represent the general structure of the dairy cattle sector in the region. Data were collected via face-to-face surveys, and the scale’s reliability was confirmed (Cronbach’s Alpha: 0.742) and suitability for Factor Analysis (KMO: 0.710) was verified. The results showed that while 88.33% of the farmers were members of a cooperative/union and 57.50% reported timely colostrum administration (within the critical <4 hours), these positive indicators contrasted sharply with low biosecurity and poor practical application. Specifically, calf mortality was high (42.50% of farms reported mortality rates >5%), mainly due to diarrhea and pneumonia, with 65.83% of deaths occurring in the first 30 days. Critical management deficiencies included uncontrolled colostrum feeding (85.00% via suckling, risking failure of passive transfer), severe biosecurity breaches (85.83% of calves housed with adult animals), and delayed introduction of solid feed. In conclusion, the primary challenge in Çorum is not lack of institutional access or basic knowledge, but rather a critical disconnection between theoretical knowledge and practical management implementation. To improve calf survival, management strategies should shift from traditional suckling to controlled colostrum protocols and emphasize the transition from group housing to individual calf hutches to ensure biosecurity.
AtıfOpenAlex1İncele - MakaleAçık Erişim2026Investigation of Structural Characteristics and Flock Management Practices of Sheep Breeding Farms: The Alaca District of Çorum Province Example
Bayraktar, Bülent; Aydemir, Seyma; Kotan, Gökşad Cemil; Küçük, Gülben
The aim of this study is to comprehensively examine the structural characteristics and herd management practices of sheep farms in Alaca district of Çorum province and to reveal their current status through a survey conducted on 130 sheep farms. The study revealed that the breeder population in the sector is concentrated in young (18-30 years old) and middle-aged (31-40 years old), with the younger generation actively participating in the sector. The vast majority of breeders view livestock farming as their primary source of income, with a predominant portion of their farms focusing on slaughter and sacrificial animal husbandry. While basic facilities such as resting areas, lighting, and ventilation are largely adequate, the lack of specialized enclosures necessary for modern herd management, such as sick animal pens (48.46%), milking parlors (86.92%), and shearing areas (100.00%), is striking. In terms of herd management practices, the most common age for first mating for females was 15 months. Rams are kept in the flock only during the breeding season in the majority of farms, and the most frequently used breeding method is reported to be free-breeding (pen breeding/pasture breeding). Underweight birth was identified as the primary cause of lamb mortality at 46.92%. Although the vast majority of farms regularly administer official vaccinations, only a small percentage conduct regular hoof checks and care, highlighting deficiencies in preventative herd protection practices. Furthermore, although almost all breeders use village communal pastures or highland pastures, 90.00% of breeders believe pastures are inadequate, primarily attributing this inadequacy to the small size of pasture areas. In conclusion, despite its young and well-organized Sheep sector in Çorum, it exhibits significant deficiencies in modern herd management infrastructure and preventative herd protection practices, and faces a critical pasture availability problem. Therefore, to ensure sustainability and enhance competitiveness, it is crucial for local governments to encourage pasture improvement and forage production, as well as expand grant/support mechanisms for the development of modern shelter infrastructure.
AtıfOpenAlex1İncele - MakaleAçık Erişim2026General Structure of Cattle Farming Enterprises and Basic Care and Feeding Practices of Breeders: The Example of Çorum City Center
Bayraktar, Bülent; Tekce, Emre; Aydemir, Seyma; Kotan, Gökşad Cemil; Kebapcı, Eren
This study examined the general structure of cattle farming operations enterprises in the central district of Çorum city center and the basic care and feeding practices of breeders based on a survey conducted on 130 cattle enterprises between May and June 2023. Cattle enterprises in Çorum city center are generally small to medium-sized; 43.08% of these operations have a capacity of 11-30 animals, while 71.54% are owned by the breeders themselves. Breeders in these operations are predominantly male (82.31%), with the largest age group being between 31 and 40 years old, at 36.15%. Livestock farming is the population source of income for 83.85% of breeders, and their education levels are increasing, with 32.31% of breeders now high school graduates. Breeders combine family knowledge with information from official institutions and organizations as a source of knowledge and experience, and 58.46% rely on experience in their livestock feeding decisions. Animals are generally fed twice a day, with a 90% mix of roughage and concentrate, while automatic waterers (48.46%) are preferred for providing drinking water. However, since 67.69% of concentrate needs are met externally, there is external dependency, and 81.54% of breeders face a pasture shortage. 60.77% of the barns are located adjacent to or below the house, and reinforced concrete (67.69%) is used as the construction material. Regarding cleaning practices, straw (73.85%) is the most preferred bedding material in the barns, general cleaning is done 1-3 times a year, and manure is removed manually and deposited in the open areas (86.15%). 86.15% of breeders are members of breeder associations, and the most frequently received support is pedigree and preliminary pedigree support (89.23%). 68.46% of enterprises maintain an animal registration system. As a result, cattle enterprises in Çorum have a structure that combines traditional methods with modern practices. The breeders' high organizational awareness and propensity for record keeping indicate that the sector has potential for future growth. However, further improvements are needed in areas such as the use of professional nutrition resources and manure management.
- MakaleAçık Erişim2026Assessment of The Relationship Between Telomere Length and Physiological Parameters in Cattle Infected with Bovine Leukosis Virus
Ince, Omer Baris; Bayraktar, Bülent; Tezcan, Erdem; Korkmaz, Serol; Sait, Ahmet
The study aims to investigate the relationship between relative telomere lengths and various physiological parameters in cattle infected with bovine leukosis virus, as well as to identify the risk factors associated with cow-level bovine leukosis virus infection in dairy cattle in Türkiye. Three variables—age, parity, and body condition score—were used for risk assessment. Antibodies specific to bovine leukosis virus were detected using an enzyme-linked immunosorbent assay, and relative telomere lengths were measured by polymerase chain reaction. The highest seropositivity rate (39.13%) was observed in cattle with a body condition score of 3–3.5 and aged between 2–8 years. relative telomere length was found to be positively correlated with seropositivity, advanced age, and parity, while a negative correlation was observed between seropositivity and body condition score. Relative telomere lengths in bovine leukosis virus-infected cattle were significantly shorter (P < 0.05) than those in non-infected cattle. Among body condition score groups, the shortest relative telomere lengths were found in bovine leukosis virus-infected cattle with body condition score ≤ 2.5 and in non-infected cattle with body condition score 3–3.5. Regarding age groups, the shortest relative telomere lengths were observed in bovine leukosis virus-infected cattle older than 8 years (P < 0.05), as well as in non-infected cattle of the same age group (P < 0.05). In conclusion, relative telomere lengths in bovine leukosis virus-infected cattle were found to be significantly shorter than in non-infected cattle (P < 0.05). The shortest relative telomere lengths were recorded in both bovine leukosis virus-infected and non-infected cattle over 8 years of age (P < 0.05). Finally, the association between bovine leukosis virus infection and relative telomere lengths, along with other factors such as age, parity, and body condition score, is considered potentially useful for disease control and prevention programs.
AtıfOpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ3Neurobiological and psychological effects of reciting the Quran from the Mushaf
Okur, Süheyb; Bayraktar, Bülent
Background: This study aims to examine the acute neurobiological effects of reciting the Quran from the Mushaf on salivary BDNF, Apelin, and Cortisol levels and their relationship with emotional state. Methods: The study employed a randomized pre-test post-test control group design conducted in Türkiye. The sample consisted of 100 healthy theology students (50 females, 50 males) aged 18–25, proficient in reciting the Quran in accordance with Tajweed rules. Participants were randomly assigned to either the experimental group (reciting the first nine verses of Surah Al-Imran, n = 50) or the control group (standardized passive resting, n = 50). Salivary BDNF, apelin, and cortisol levels were measured using the ELISA technique before and after the intervention. Emotional states were assessed using the Mood Scale and the Psychological Well-being Scale. Results: The experimental group exhibited a statistically significant increase in mean salivary BDNF and apelin levels and a significant decrease in cortisol levels following recitation compared to the passive control group (p < 0.05). In terms of gender, no statistically significant differences were observed in biomarker responses (p >.05). Correlation analysis revealed a significant “biological reciprocity,” where cortisol showed a negative correlation with apelin (r = -0.436, p < 0.001) and BDNF, while correlating positively with negative emotions. Conclusions: Reciting the Quran aloud acts as a rapid psychophysiological intervention that downregulates the HPA axis (reduced cortisol) and upregulates neurotrophic factors (increased BDNF and apelin). These findings suggest that structured recitation functions as a restorative neuroplasticity practice, promoting biological stress resilience associated with psychological well-being.
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İncele - MakaleYayıncıda açık erişim2026Scopus SJRQ2Metabolic, adipokine (irisin, spexin, visfatin), and ER stress (GRP78) responses in multiparous Brown Swiss cows: a multivariate approach across physiological stages and body condition scores
Kotan, Gökşad Cemil; Aydemir, Şeyma; Bayraktar, Bülent
This study investigated the responses of novel adipokines (irisin, spexin, visfatin), an endoplasmic reticulum (ER) stress marker (GRP78), and traditional metabolic parameters (non-esterified fatty acids (NEFAs), beta-hydroxybutyrate (BHBA), urea, albumin, globulin, total cholesterol) in 360 healthy Brown Swiss dairy cattle. The animals were categorized into 18 subgroups based on pregnancy stages (early, mid, dry), lactation stages (early, mid, late), and body condition scores (BCSs). Serum analyses were performed using ELISA and spectrophotometric methods. Interactions between physiological stages and BCS were highly significant for all measured parameters (p<0.001). Results showed that mean serum levels of spexin (ranging from 14.02 to 36.04 pg mL−1) and irisin increased as pregnancy and lactation progressed. Visfatin levels exhibited a significant increase specifically during the gestation period, peaking during the dry period (24.09 ng mL−1), and maintained a significant increasing trend as lactation progressed toward the late stage (Tables 2, 4). Conversely, GRP78 (peaking at 0.46 ng mL−1), NEFA (peaking at 0.52 mmol L−1), and urea levels peaked during the dry period and early lactation, subsequently decreasing as metabolic stability was achieved. Notably, during the dry period, stress markers rose despite declining albumin and globulin levels (p<0.05). These data indicate that the dry period and early lactation are the most critical phases for metabolic and cellular stress, characterized by lower spexin and elevated GRP78 and NEFA concentrations. The later rise in irisin and visfatin, while BHBA remained within physiological limits, confirms successful metabolic adaptation (p<0.001). In conclusion, the integrated evaluation of these novel biomarkers is anticipated to provide significant contributions to protective strategies and metabolic management in dairy cattle.
- MakaleAçık Erişim2026Scopus SJRQ1Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs
Kotan, Gökşad Cemil; Bayraktar, Bülent
Background: This study investigated the effects of dietary graviola (Annona muricata L.) oil extract (GOE) (supplemented at 200, 400, and 600 mg/kg) on the growth performance and circadian rhythm profiles of adipokine, cardiac, and mitochondrial function biomarkers in 48 male Anatolian Merino lambs (2.5 months old). Methods: Lambs were assigned to a control group (G0) or supplementation groups (G200, G400, G600 mg/kg) for a 60-day trial (70 days total). The study was conducted under a 12-h light/12-h dark cycle to ensure controlled environmental conditions. To analyze circadian profiles, blood samples were collected on days 0, 15, 30, 45, and 60 at four time points (07:00, 13:00, 19:00, and 01:00). Serum levels of Apelin, cTnI, BMAL1, MOTS-c, and BMCP1 were measured by ELISA. Data were analyzed using GLM Multivariate analysis (p < 0.05). Results: Key findings showed the G400 dose resulted in the most effective linear increase in live weight and live weight gain by day 60, and had a significant overall effect on live weight (p < 0.05). The G200 dose significantly improved the feed conversion ratio (p < 0.05), while feed consumption was unaffected (p > 0.05). Regarding biomarkers on day 60, the G400 dose effectively modulated BMAL1, MOTS-c, and BMCP1 (peak at 19:00). The G600 dose yielded the best results for Apelin (peak at 19:00) and cTnI (peaks at 13:00 and 07:00). Conclusions: In conclusion, GOE at a dose of 400 mg/kg (G400) not only optimizes fattening performance in Anatolian Merino lambs but also supports metabolic homeostasis by modulating adipokine levels, cardiac function, and mitochondrial biogenesis processes in a manner consistent with the circadian rhythm. These findings demonstrate that the G400 dose is a safe and effective phytogenic strategy for improving animal health and production efficiency.
- MakaleAçık Erişim2026Scopus SJRQ4Virucidal and antiviral activities of maca (Lepidium meyenii) root powder on three pathways of Norovirus as a foodborne pathogen; [Actividades viricidas y antivirales del polvo de raíz de maca (Lepidium meyenii) en tres vías del norovirus como patógeno transmitido por los alimentos]
Korkmaz, Irem Omurtag; Korkmaz, Serol; Parmasiz, Ayse; Mavili, Seda; Bayraktar, Bülent; Sait, Ahmet; Keles, Aysen Gargili
Vitamin C equivalency, the cytotoxicity on murine macrophage cells, and the virucidal and antiviral activities of maca (Lepidium meyenii) powder on murine norovirus (MNV) as a norovirus surrogate for human as a foodborne pathogen were studied. The antioxidant capacity of the maca was determined by MTT assay as vitamin C equivalency (VCEAC). The 50% cytotoxic concentration (CC50) was calculated with the linearity of maca concentrations-cell viability. The activities of maca against the virus was determined as the 50% tissue culture infective dose with Spearman–Karber method. The VCEAC of maca linearly increased with the concentration. The non-cytotoxic concentrations of maca were measured on murine macrophage with a CC50 of 5.77 mg/mL and a CC80 of 1.28 mg/mL. As maca reduced the virus titration based on contact time in the virucidal assay in several conditions, it did not significantly inhibit MNV on three infectivity pathways of host cell at non-cytotoxic concentrations of maca. The result of this first study presented that despite its ineffective in the treatment and prophylaxis of norovirus infection, maca might be an alternative food additive and preservative against human norovirus as an important foodborne pathogen causing outbreaks worldwide. © Los autores. Este artículo es publicado por la Rev Inv Vet Perú de la Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos. Este es un artículo de acceso abierto, distribuido bajo los términos de la licencia Creative Commons Atribución 4.0 Internacional (CC BY 4.0) [https://creativecommons.org/licenses/by/4.0/deed.es] que permite el uso, distribución y reproducción en cualquier medio, siempre que la obra original sea debidamente citada de su fuente original
- MakaleAçık Erişim2026Scopus SJRQ2Acute Music-Frequency Exposure Modulates Salivary Stress and Neurotrophic Markers in Young Adults: A Randomized Controlled Trial
Bozok, Ümmü Gülşen; Özcan, Gülbahar Böyük; Bayraktar, Bülent; Özen, Doğukan
Background: The exam period is a period full of intense stress and anxiety that deeply affects cognitive and physiological responses for university students. Listening to music has the potential to protect cellular health and alleviate the negative effects of stress by affecting individuals' mood, and cognitive functions. This study aimed to investigate the differential effects of 528 and 432 Hz music frequencies on salivary BDNF, CREB, and GRP78 levels in young adults, along with their association with cognitive performance under exam-related stress. Methods: A total of 162 healthy university students were randomly assigned to three groups: no music (control), 528 Hz instrumental music, and 432 Hz instrumental music. Participants listened to music for 20 min, after which saliva samples were collected and analyzed for brain-derived neurotrophic factor (BDNF), glucose-regulated protein 78 (GRP78) and cyclic AMP response element-binding protein (CREB) levels using ELISA. Cognitive performance was assessed using the Stroop word-color test administered by medical doctor. Results: Exposure to 528 Hz music significantly increased salivary BDNF (3.84 [2.76–4.13]) and CREB levels (1.5 [1.38–1.59]) compared to control (p < 0.05), whereas GRP78 levels were elevated in the 432 Hz group (0.51 [0.47–0.58]) (p < 0.05). No significant differences were observed between groups in Stroop test performance. Conclusion: These findings suggest that specific music frequencies elicit distinct biological responses under exam-related stress, even in the absence of immediate cognitive performance differences. Salivary neurotrophic and stress-related biomarkers may offer valuable non-invasive insights into music's neuromodulatory effects. Trial Registration: ClinicalTrials.gov identifier: AMU-EC-8522.
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İncele - MakaleAçık Erişim2026Scopus SJRQ2Recitation Mode Is Associated With Salivary CREB and Cortisol Responses during Qur'anic Recitation
Okur, Süheyb; Topyay, Yusuf; Bayraktar, Bülent
Background: Spiritual practices such as Qur'anic recitation are commonly associated with psychological and physiological regulation; however, their salivary biomarker correlates remain insufficiently understood. This exploratory study examined whether different modes of Qur'anic recitation were associated with changes in salivary cAMP response element-binding protein (CREB), a biomarker related to plasticity-associated pathways, and cortisol, a marker of hypothalamic-pituitary-adrenal axis activity. Methods: The sample comprised three nonrandomized, criterion-defined conditions: Passive Control (n = 20; participants unable to read Qur'anic Arabic), Sight-Reading (n = 30), and Memorized Recitation (n = 30). Saliva samples were collected immediately before and after the experimental task or passive rest period. Salivary CREB and cortisol concentrations were quantified using ELISA. Post-task CREB levels were analyzed using ANCOVA with baseline CREB as a covariate. Cortisol responses were analyzed using change scores, Welch's ANOVA, and an additional robust factorial model with HC3 heteroscedasticity-consistent standard errors to evaluate exploratory Condition × Gender patterns. Results: After controlling for baseline CREB levels, experimental condition had a significant effect on post-task salivary CREB, F(2, 76) = 8.16, p < 0.001, η2p = 0.18. Memorized recitation showed higher adjusted post-task CREB levels than both sight-reading and passive control conditions. Cortisol change scores also differed significantly across conditions, Welch's F(2, 40.02) = 30.76, p < 0.001. Both active recitation conditions were associated with cortisol reduction relative to passive rest, with no significant difference between sight-reading and memorized recitation. Although descriptive data suggested a possible gender-related divergence in the memorized recitation condition, the Condition × Gender interaction did not remain statistically significant under robust estimation and was therefore interpreted as exploratory. Conclusion: These preliminary findings suggest that Qur'anic recitation modes are associated with distinct salivary biomarker patterns. Memorized recitation was linked to higher adjusted salivary CREB levels, whereas both active recitation modes were associated with cortisol attenuation relative to passive rest. Because the present design did not include active non-Qur'anic vocalization or neutral reading control conditions, the specificity of these effects to Qur'anic content cannot be determined. Future studies should include active control conditions and larger gender-stratified samples to clarify the mechanisms underlying these biomarker responses.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ1Effects of Moringa oleifera Oil on Adipokine Responses, Inflammation, Oxidative Stress, Bacterial Burden, and Early Survival in CLP-Induced Septic Rats
Ülker, Ufuk; Bayraktar, Bülent; Alr, Mehmet Eray; Kızıl, Sibel; Karan, Tünay; Kotan, Gökşad Cemil; Yeni, Mustafa
Moringa oleifera has anti-inflammatory and antioxidant properties, but its effects in polymicrobial sepsis are incompletely defined. We evaluated M. oleifera oil (MOO) in female Wistar rats subjected to cecal ligation and puncture (CLP). Forty rats were randomized to Control, Sham, CLP, CLP + MOO 100 mg/kg, or CLP + MOO 200 mg/kg (n = 8/group). At 24 h, survival, clinical scores, serum apelin, omentin-1, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), recoverable bacterial burden, and histopathology were assessed. CLP decreased omentin-1 and increased IL-6, TNF-α, MDA, recoverable Staphylococcus aureus and Escherichia coli, clinical severity, and multi-organ injury. At 200 mg/kg, apelin and omentin-1 were 1.15 ± 0.12 and 28.4 ± 3.1 ng/mL, while IL-6, TNF-α, and MDA decreased to 18.4 ± 1.8 pg/mL, 24.1 ± 2.8 pg/mL, and 2.5 ± 0.3 nmol/mL, respectively. Neither organism was recovered above the detection limit. Survival was 62.5% in CLP, 87.5% with 100 mg/kg, and 100% with 200 mg/kg MOO. Within this 24 h model, a single post-CLP oral dose of MOO was associated with lower inflammatory cytokine concentrations and MDA, reduced recoverable bacterial burden, improved clinical and histopathological findings, and higher descriptive survival. Because MDA was the sole oxidative endpoint and no non-septic MOO-only group or molecular redox assays were included, these findings support the attenuation of sepsis-associated lipid peroxidation but do not establish a direct antioxidant mechanism.
- MakaleAçık Erişim2026Scopus SJRQ2Modulation of stress and neuroplasticity biomarkers via rhythmic vocalization: a controlled study on NDNF, cortisol, and monoamines
Okur, Süheyb; Bayraktar, Bülent
Background: The aim of this study is to investigate the effect of reciting the Quran (from Mushaf) on serotonin, dopamine, NDNF, and cortisol levels in relation to mental well-being. Methods: This study was conducted on a sample of university students who know how to read the Quran in Türkiye, selected by a non-probability method, with a pre-test-post-test control group and a longitudinal design; the assignment to the groups was also done randomly. The research was carried out with 72 university students (36 female, 36 male), aged 19–30, who know how to read the Quran and do not have any health problems. Two groups were formed: a 36-person experimental group and a 36-person passive resting control group. The Mental Well-Being Scale and a personal information form were used to evaluate the participants’ well-being status. Salivary serotonin, dopamine, NDNF, and cortisol levels were examined using the ELISA technique in samples taken before and after the experimental group recited verses 195–200 of Surah Al-i Imran aloud. Number, percentage, mean, Pearson correlation, and ANOVA tests were used to evaluate the data. Statistical significance was accepted as p <.05 for all analyses. Results: A significant group-time interaction was found (p <.05). Compared to the passive resting control group, the experimental group showed statistically significant increases in salivary serotonin, dopamine, and NDNF levels, and a significant decrease in cortisol levels. However, a critical dissociation was observed: despite this neuroprotective biomarker profile, the control group reported statistically significantly higher post-intervention mental well-being scores than the experimental group (p <.05). This suggests that the acute cognitive load and performance anxiety associated with the recitation task may temporarily mask physiological benefits in self-reports. Conclusions: A brief (5-minute) ‘Tartil’ recitation of the Quran demonstrates immediate, positive neurobiological effects by reducing stress hormones (cortisol) and increasing reward- and neuroplasticity-related biomarkers (dopamine, serotonin, NDNF). However, this did not immediately translate to higher self-reported well-being, suggesting the relationship between the neurobiology of recitation and its perceived psychological effects is complex and potentially confounded by factors such as performance anxiety or cognitive load in an experimental setting. Clinical trial number: Not applicable.
AtıfScopus2WoS3OpenAlex4İncele - MakaleAçık Erişim2025Assessment of Nucleic Acid Extraction Kits for SARS-CoV-2 Surveillance in Wastewater Samples
Bayraktar, Bülent; Aslan, İsmail; Korkmaz, Serol; Parmaksız, Ayşe; Sait, Ahmet
Objective: The aim of this study is to evaluate the effectiveness of three commercial nucleic acid extraction kits (kit A, B and C) in isolating SARS-CoV-2 viral RNA from wastewater samples. Method: In this study, water samples were collected in March 2021 from three wastewater treatment plants located in different parts of Istanbul, and it was confirmed that they were negative for SARS-CoV-2. Different concentrations of the SARS-CoV-2 virus, previously inactivated at the BSL-3 laboratory of the Pendik Veterinary Control Institute, were added to the wastewater samples. RNA extraction and quantification were performed using commercial nucleic acid extraction kits and and RT-qPCR kit specific to SARS-CoV-2. Results: At the end of the study, it was determined that kit C yielded the highest total RNA and produced more consistent results, significantly outperforming the other two kits in terms of RNA yield and purity. Statistical analysis revealed significant differences in RNA concentrations (p < 0.05) and gene copy numbers (p < 0.01) between the kits, and kit C demonstrated superior linearity and reproducibility. Conclusion: According to the findings, although all three evaluated kits are suitable for detecting SARS-CoV-2 RNA in wastewater samples, kit C provides the most efficient and reliable performance, especially for high-throughput studies. Additionally, this study highlights the importance of selecting appropriate nucleic acid extraction methods for wastewater surveillance, which serves as an early warning system for outbreaks that threaten public health.
AtıfOpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ1Investigation of endocrine and cerebral response and nutrition and physical performance parameters according to bigorexia nervosa levels: a cross-sectional study in sports sciences faculty students
Erkılıç, Ali Ozan; Bayraktar, Bülent; Erkiliç, Tuğçe Orkun; Türkmen, Mutlu; Kul, Murat; Yönal, Mehmet
The aim of this study is to investigate the effects of Bigorexia nervosa (BGN) levels on endocrine (Asprosin, GLP-1) and cerebral (BDNF) responses and nutritional and physical (6MWT, Six-Minute Walk Test)), speed, metabolic equivalent unit (MET)) performance parameters in students of the faculty of sports sciences. This study investigated muscle dysmorphic disorder (MDD), physical activity levels, and specific hormonal markers in 120 university students (63 females, 57 males) aged 18–25 years, all studying sport sciences and reporting no existing health problems. Participants completed a demographic questionnaire, food frequency questionnaire and the Muscle Dysmorphic Disorder (Bigorexia) Inventory through face-to-face interviews. Physical activity was assessed using the 6-Minute Walk Test (6MWT) to measure walking distance, and Metabolic Equivalent (MET) was calculated based on the American College of Sports Medicine (ACSM) formula. Body Mass Index (BMI) was determined from anthropometric measurements of height and body weight. Saliva samples were collected to analyze Asprosin, BDNF, and GLP-1 hormone levels using the ELISA technique.Data were analyzed using number, percentage, mean, chi-square, t-test, Pearson correlation, and ANOVA tests. In all analyses, significance was accepted as p < 0.05. According to the demographic findings of the study, the majority of participants (64.2%) were third-year students, and 52.5% were female. The mean age of the participants was 22.01 years, the mean height was 168.59 cm, and the mean weight was 62.61 kg. 73.3% of the individuals were classified as normal weight, 12.5% as pre-obese, 11.7% as underweight, and 2.5% as obese. Men had significantly higher bigorexia and its subscale scores than women (p < 0.05), and bigorexia was positively correlated with height and negatively correlated with BMI (p < 0.01). Mean salivary BDNF levels were higher in participants consuming 1–2 meals per day (p = 0.035), and mean salivary asprosin levels were significantly higher in the obese group compared to the healthy group (p = 0.008). Additionally, a strong positive correlation was found between asprosin and GLP1 levels (r = 0.585; p < 0.01). Bigorexia status was significantly associated with meat, meat products, and fat consumption (p < 0.05), while no association was found with physical performance parameters such as 6MWT, speed, and MET (p > 0.05). The average MET value was found to be 4.53, indicating that participants generally engaged in moderate-intensity physical activity. In conclusion, examining endocrine (asprosin, GLP-1) and cerebral (BDNF) hormone responses, as well as nutritional and physical performance parameters, according to BGN levels reveals the impact of BGN on physiological and nutritional behaviors. Given the impact of BGN trends on students’ health, examining hormone profiles and their relationships with physical performance and nutrition is believed to significantly contribute to understanding the health problems associated with BGN and developing appropriate interventions.
- MakaleAçık Erişim2025Scopus SJRQ3Effect of Moringa oleifera Oil Extract on Adipokine (Apelin, Visfatin and Nesfatin-1) and Cardiac (cTnI) Response in Streptozotocin-induced Rats
Orkun Erkiliç, Tuğçe; Bayraktar, Bülent
Background: The aim of this study was to investigate the effects of Moringa oleifera extract (MOE) added to the diets at different amounts on Adipokine (apelin, visfatin and nesfatin-1) and Cardiac (cardiac troponin I (cTnI)) Response in Streptozotocin (STZ)-induced Type 1 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. Eight (8) groups were created, with 8 rats in each group: Control (C), M100 (MOE 100 mg/kg group given with oral gavage route of administration (OGRA), M200 (MOE 200 mg/kg group given with OGRA), M300 (MOE 300 mg/kg group given with OGRA); STZ 55 mg/kg i.p administered group, Diabetic control group (DC), DM100 (D+100 mg/kg MOE), DM200 (D+200 mg/kg MOE), DM300 (D)+300 mg/kg MOE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein (Vena caudalis) of all subMects on days 0 and 21 of the study. Apelin, visfatin, nesfatin-1 and cTnI levels in the serum samples were measured by ELISA method. Result: In the present study, the most significant increase in mean serum apelin, visfatin, nesfatin-1 and cTnI levels in diabetes groups was observed in DC groups, while the most significant decrease due to MOE addition was observed in DM200 groups (p<0.01). As a result, it was concluded that MOE may be safe and beneficial when administered at a dose of 200 mg/kg in rats with STZ-induced diabetes.
AtıfScopus3WoS4İncele - MakaleAçık Erişim2025Scopus SJRQ1Emotion regulation skills, brain-derived neurotrophic factor, cortisol hormone levels in primary school students in Türkiye: a cross-sectional and correlational analysis study
Kırbaş, Zila Özlem; Bayraktar, Bülent; Odabaşi Aktaş, Elif
Background: Hormones are molecules that contribute significantly to mental and physical health due to their role in emotion regulation (ER) processes. However, the role and effect of hormones on the ER has not yet been fully elucidated. In this study, it was aimed to examine the salivary Brain-derived neurotrophic factor (BDNF) and cortisol hormone response to support ERS in primary school students depending on some parameters. Method: This cross-sectional and correlational study was conducted in the Eastern Black Sea Region of Türkiye between April 2023 and June 2023. In the sample selection, after the number of students was determined in proportional stratification, the sample selection method was made by simple random selection from each class list, first according to the school and then the grade level of each school. A total of 177 healthy students between the ages of 8 and 10 who attended these schools, were allowed to participate in the research by their families, and were volunteers, were included in the study. Data were collected using the Personal Information Form and the Emotion Regulation Scale for Children and saliva collection cups. Human-specific Brain-derived neurotrophic factor ELISA Kit (BT LAB, Cat.No E1302Hu, CHINA) for measuring BDNF levels in saliva; In measuring the level of cortisol hormone in saliva, Human Cortisol ELISA Kit (BT LAB, Cat.No E 1 003Hu, CHINA) was used in accordance with the procedure specified in the manufacturer’s catalogue. Data were evaluated using the SPSS 26.0 for Windows (SPSS, Chicago, Il, USA) package program. Independent Samples Test and One-Way ANOVA test, correlation and Multiple Linear Regression analysis were used to evaluate the data. P <.01 and p <.05 significance levels were used as statistical significance values. Results: A statistically significant correlation was found between the mean total score of the Emotion Regulation Skills Scale for Children and the mean level of salivary BDNF, and a negative correlation between the mean level of salivary cortisol (p˂0.01). Conclusions: Within the scope of the data obtained in our current study, BDNF levels were found to be high and cortisol hormone levels to be low in children with high ERS.
AtıfScopus5WoS4OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ2The Relationship Between Metacognitive Beliefs and Salivary Cortisol, BDNF, and NDNF Levels: A Cross-Sectional Study
Okur, Süheyb; Bayraktar, Bülent; Tosun Köse, Fatma
Purpose: The main objective of this study is to non-invasively investigate the relationship between metacognitive beliefs and cortisol, the primary stress output of the hypothalamic-pituitary-adrenal (HPA) axis, as well as neurotrophic factors associated with neuroplasticity brain-derived neurotrophic factor and neuron-derived neurotrophic factor (BDNF and NDNF). Within this framework, the hypotheses that negative metacognitions would be associated with increased cortisol and decreased BDNF levels, and that cortisol might play a mediating role in this relationship, were tested. Method: The study was designed in a cross-sectional model with 60 university students. Participants' metacognitive beliefs were measured using the Metacognitions Questionnaire-30 (MCQ-30). Salivary cortisol, BDNF, and NDNF levels were analyzed using the ELISA method. Pearson correlation and hierarchical multiple regression analyses were used for data analysis. Finding: The results showed a significant positive relationship between the total metacognition score and cortisol (r = 0.589, p < 0.01) and a strong negative relationship between cortisol and BDNF (r = −0.662, p < 0.01). Hierarchical regression analysis supported a partial mediation model, indicating that dysfunctional metacognitive beliefs have both a significant direct negative association with BDNF and an indirect association mediated by cortisol. In the final model, both metacognition (β = –0.298, p < 0.05) and cortisol (β = –0.281, p < 0.05) were significant factors associated with lower BDNF levels. NDNF showed a positive relationship with BDNF (r = 0.571) but not with other variables. Conclusion: These findings point to a psychobiological model where dysfunctional metacognitive beliefs are linked to suppressed neuroprotective mechanisms like BDNF, both directly and indirectly through HPA axis activation. The results shed light on the potential neurobiological mechanisms underlying the effectiveness of metacognitive therapies.
AtıfScopus4WoS4OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ1The relationship between emotional intelligence levels, stress management skills and hormonal and cerebral responses in university students
Bayraktar, Bülent; Battal, Fetullah
Background: Emotional intelligence is a person’s ability, capacity and ability to understand, use, understand, manage, anticipate, manage and direct the emotions of oneself or others. Students with high levels of emotional intelligence express themselves better, are more resistant to stress in their lives, and are individuals who can direct their emotions. Leaders with strong emotional intelligence will create synergy for all employees. Therefore, emotional intelligence and stress management skills are important issues in the field of leadership and organizational behavior. At the same time, emotional intelligence and stress management skills interact with hormones. This study aims to examine the emotional intelligence levels and hormone (apelin, cortisol) and cerebral (Brain-derived neurotrophic factor (BDNF)) response of 4th-year students of the faculty of health sciences at the university, who are potential managers of the future in terms of some variables. Methods: The research was conducted using the cross-sectional data method with 167 university students aged 18–24 who were reported to be clinically healthy in Türkiye. Apelin, cortisol hormone and BDNF levels in the participants’ saliva samples were analyzed using the ELISA technique. The relationship between emotional intelligence level and total scores from the stress coping scale and salivary apelin, cortisol and BDNF levels were evaluated. Results: In the study, it was determined that the average level of apelin hormone in saliva was “2.36 ± 0.076)’’ ng/mL in girls and “2.57 ± 0.071’’ ng/mL in boys. In girls, the BDNF level was “3.19 ± 0.97’’ and the cortisol level was “2.04 ± 0.72’’. BDNF level in boys is “3.41 ± 0.94’’and cortisol level is “1.92 ± 0.59’’. There is a significant difference between the participants’ allowances (income levels) and the average levels of salivary apelin hormone, BDNF and emotional intelligence scale (p < 0.01). A positive, strong and statistically significant relationship was found between the participants’ emotional intelligence level and stress management skills and apelin and BDNF levels, and a negative, strong and statistically significant relationship was found between salivary cortisol levels (p˂0.01). Conclusions: High emotional intelligence and stress management skills are an important element of strategic importance for a successful management and professional success process in individuals who will work in fields that need people such as health, marketing, law, consultancy, medicine, teaching and the service sector. Our study determined that as university students’ emotional intelligence levels strengthened, the participants’ stress management skills, salivary apelin, and BDNF levels increased, and cortisol hormone levels decreased. As a result, monitoring and examining apelin, BDNF, cortisol hormones can be useful parameters in evaluating the interaction between individuals’ emotional intelligence level and stress management skills and hormone response.
AtıfScopus3WoS3OpenAlex5İncele - MakaleAçık Erişim2024Covid-19 Pandemisi Sonrası Spor Bilimleri Fakültesi Akademisyenlerinin Siberkondria Düzeyleri ve İnfodemide Davranışları Beslenme Durumları ile Bazı Değişkenler Arasındaki İlişkinin İncelenmesi: Pilot Çalışma
Erkılıç, Tugçe Orkun; Bayraktar, Bülent; Erkılıç, Ali Ozan
Bu çalışma Covid-19 sonrası dönemde akademik personelin siberkondria ile infodemi düzeyleri arasındaki ilişkiyi ve beslenme durumlarını belirlemek amacıyla yapılmıştır. Kesitsel tipteki bu araştırma, Bayburt Üniversitesi Spor Bilimleri Fakültesinde görev yapan 23 Akademik personel ile yapılmıştır. Tüm katılımcılara demografik özelliklerinin ve beslenme durumlarının ve besin tercihlerinin belirlenmesine yönelik bir anket uygulanmıştır. Verilerin toplanmasında Siberkondri Şiddet Ölçeği-Kısa Formu, İnfodemi (Dijital Ortamda Sağlık Bilgisi Edinme ve Teyit) Ölçeği ve Besin Tüketim Sıklığı formu kullanılmıştır. Çalışmada, ölçeklerin alt faktörlerinden aşırılık ile Web 1.0 ve Sağlık Bilgisi edinme arasında ve alt faktörlerden güvence ile Web 2.0 ve Dijital sağlık bilgisi edinme arasında pozitif bir ilişki belirlenmiştir. Katılımcıların aşırılık düzeyi yani sağlıklarıyla ilgili araştırmalarının artan ve tekrar eden yapısı arttıkça, sağlık bilgisi edinme düzeylerinin de arttığı tespit edilmiştir (p<0,05). Aynı zamanda katılımcıların profesyonel tıbbi tavsiye almaya yönlendiren araştırmalar (güvence düzeyi) arttıkça, dijital sağlık bilgisi edinme düzeylerinin de artması üzerinde anlamlı bir etkiye sahip olduğu bulunmuştur (p<0,05). Çalışma sonucunda Covid-19 sonrası dönemde akademik personelin siberkondria ile infodemi düzeyleri arasında pozitif yönde anlamlı bir ilişki olduğu ortaya konulmuştur. Covid-19 pandemisi sonrası siberkondri ve infodemi davranışlarındaki artış, bireylerin beslenme durumları ile doğru besine yönelmesi konusunda diyetisyenlerin önemi ve gerekliliğini ortaya koymuştur. Mevcut sonuçlarımızın bu alanda gerçekleştirilecek çalışmalar ve araştırmacılar için önemli katkı sağlayacağını düşünmekteyiz.
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