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  • MakaleAçık Erişim2023
    Performance Analyses of Combined Cycle Power Plants

    Karaali, Rabi

    In this article, different compressor pressure and different excess air rates for a gas turbine based combine cycle power plant with steam Rankine cycle as bottoming cycle were analyzed by using 1. and 2. laws of thermodynamics and exergy analyses methods to obtain the best performances of the cycle. Exergy efficiency of the cycle, net powers of the gas and steam turbines and the overall cycle, exergy loss of the components, the efficiencies of the components are obtained, compared and discussed. It was found that, increasing the compressor pressure increases exergy efficiency of cycle, gas turbine and total plant power, and the combustion chamber, the HRSG and the compressor efficiencies. However, increasing compression rates decreases steam turbine power, combustion chamber, steam turbine, and HRSG exergy losses and the gas turbine efficiency. Also, it is found that, increases in excess air ratios gives an optimum or a maximum exergy efficiency, at 2.5 excess air rate of the cycle.

    • SDG 7 · Erişilebilir ve Temiz Enerji
    • SDG 13 · İklim Eylemi
    AtıfScopus3OpenAlex6
    ScopusTR Dizinİncele
  • MakaleAçık Erişim2023Scopus SJRQ2
    Efficient production of acetone butanol ethanol from sole fresh and rotten potatoes by various Clostridium strains

    Avcı, Ayşe; Kamiloğlu, Aybike; Dönmez, Sedat

    This study aimed to evaluate rotten potato in the fermentation of acetone butanol ethanol (ABE). For this purpose, three strains, Clostridium acetobutylicum DSMZ 1731, Clostridium acetobutylicum DSMZ 6228, and Clostridium beijerinckii DSMZ 6422, were used and production experiments were performed in a simple media only composed of either fresh or rotten potato. Effects of potato concentration (100–400 g/L) and time (24–144 h) on the fermentation were determined using fresh potato. The highest ABE production was detected at 400 g/L potato concentration at the end of 96 h by all strains. Clostridium acetobutylicum DSMZ 6228 was the most efficient strain in producing ABE among the microorganisms tested. Total ABE productions by Clostridium acetobutylicum DSMZ 1731, Clostridium acetobutylicum DSMZ 6228, and Clostridium beijerinckii DSMZ 6422 at 400 g/L in 96 h were 12.3, 17.6, and 12.0 g/L, respectively. The majority of the products was butanol that made up ca. 66–67% of total ABE. Significant amounts of ABE were also produced with rotten potato which was compatible with the results obtained with fresh potato. They were determined as 11.5, 17.1, and 9.6 g/L with Clostridium acetobutylicum DSMZ 1731, Clostridium acetobutylicum DSMZ 6228, and Clostridium beijerinckii DSMZ 6422, respectively. The results showed that rotten potato could be a good candidate as substrate for ABE fermentation.

    AtıfScopus18WoS16
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2023Scopus SJRQ2
    Optimization of microwave-assisted biosynthesis of silver nanoparticle with tarragon extract

    Altuncu, Fatma Kübra; Kamiloğlu, Aybike

    Response surface method was used to optimize microwave-assisted silver nanoparticle production with tarragon extract. As a result of the optimization study, tarragon silver nanoparticles (TAgNPs) were produced from 43 conditions with a degree of desirability of 1, with a processing time of 5.25 min, AgNO3 concentration of 9.89 mM, and tarragon extract concentration of 14.80%. Among the variable parameters, AgNO3 concentration affected TAgNP synthesis depending on processing time and tarragon extract concentration; tarragon extract concentration was found to significantly affect nanoparticle formation. TAgNP produced under optimum conditions was found to be crystalline, with a spherical surface morphology and an average particle size of 16.56 nm, with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction diffractometry (XRD) analyses. TAgNPs showed inhibitory effect for Escherichia coli BC 1402, Bacillus cereus BC 6830, Salmonella typhimurium RSSK 95091, Yersinia enterocolitica ATCC 27729, and Staphylococcus aureus ATCC 25923 microorganisms. The minimum inhibition concentrations were 10 µg/mL for B. cereus BC 6830, 50 µg/mL for E. coli BC 1402, S. typhimurium RSSK 95091, and Y. enterocolitica ATCC 27729, and 25 µg/mL for S. aureus ATCC 25923.

    AtıfScopus2WoS2OpenAlex2
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2023
    REGULATORY EFFECT OF GENDER AND EDUCATION DEPARTMENT STATUS ON THE RELATIONSHIP BETWEEN INCLUSIVE EDUCATION AWARENESS AND SELF-EFFICACY

    Taşyürek, Zeynep; Kodan, Hülya

    Inclusive education is based on the idea that all individuals—regardless of individual characteristics and differences—should have access to education, a fundamental right granted to all. This study examines the relationship between pre-service teachers’ inclusive education awareness and self-efficacy and the impact of different variables that may affect this relationship. For this purpose, the Awareness Scale for Inclusive Education and the Teachers’ Self-Efficacy Perception of Inclusive Education Scale were used as data collection tools. The study was conducted through a correlational survey design to understand the relationship between pre-service teachers’ Awareness of Inclusive Education scores and Teacher’s Self-Efficacy Perception of Inclusive Education scores and determine the regulatory effect of gender and the departments in which the teachers studied on this relationship. The study sample included 360 pre-service teachers who completed the Special Education and Inclusion course. Data were analyzed using SPSS 24.0 and the Process Macro plugin. The results show a significant relationship between pre-service teachers’ awareness of inclusive education and self-efficacy perceptions. Results also indicate that while the regulatory effect of gender on the relationship between pre-service teachers’ inclusive education awareness and self-efficacy perceptions was not significant, the regulatory effect of the department they belonged to was substantial.

    Scopusİncele
  • MakaleAçık Erişim2023Scopus SJRQ2
    Effect of elevated temperature on radiation shielding properties of cement and geopolymer mortars including barite aggregate and colemanite powder

    Kök, S.; Türetken, M.S.; Öksüzer, N.; Gökçe, H.S.

    This study aims to investigate the radiation shielding efficiency of cement and geopolymer-based mortars after exposure to elevated temperatures which may happen during the activation process of nuclear reactors. To contribute to the shielding properties, these binders were modified with the substitution of colemanite powder (5 and 10%), and barite aggregate was used to be an alternative to silica sand, as well. The produced specimens were exposed to 300 and 500 °C. While the colemanite powder resulted in significant retardation of setting time up to 183% for cement-based series, a set accelerator effect reaching 67% was found in the geopolymer series. Unlike expectation, the losses in mechanical and shielding properties have become more pronounced in geopolymer mortars at the applied temperatures. In particular, a significant increase reaching 28% in compressive strength of cement series was found after 300 °C exposure. It was noted that cement series with reaching a linear attenuation coefficient of 0.162 cm−1 presented more effective shielding against gamma rays when compared to that (0.134 cm−1) of geopolymers. To moderate thermal neutrons, geopolymer series reaching a linear attenuation factor of 2.799 cm−1, were found to be a more promising alternative according to cement series reaching 2.140 cm−1.

    AtıfScopus30WoS27
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2023Scopus SJRQ3
    Comparison of Phenolic Profile and Antioxidant Properties of Pulp and Seeds of Two Different Grapes Types (Vitis vinifera L. and Vitis labrusca L.) Grown in Anatolia: The Amount of Resveratrol of Grape Samples

    Kavgacı, Merve; Yukunc, Gulsah Okumus; Keskin, Merve; Can, Zehra; Kolaylı, Sevgi

    Background: Grape is the most widely cultivated fruit all over the World and it is both food and a good source of antioxidants. The fruit is rich in phytochemicals and its seed is especially a source for resveratrol, a stilbene that shows health promoting effect. Objective: In this study, phenolic profile and antioxidant properties of eight grape cultivars with two species cultivated in Turkey were compared. Isabella, Razaki, Alphonse Lavalleé, Red Globe and Emir cultivars were used. Methods: Total phenolic substance (TPS), total flavonoid substance (TFS), total antioxidant capacity (FRAP) and phenolic compositions of the pulp and the seeds were determined. Phenolic composition of grapes were found by using HPLC-UV. Results: The results showed that total phenolic substances and total antioxidant capacities were richer in the seeds than in the pulps. Catechin and epicatechin are major phenolic compounds in the grape seeds, and chrysin, pinocembrin, resveratrol, luteolin and caffeic acid phenethyl ester (CAPE) were detected in the pulp as major. Resveratrol varied from 4.50 to 101.89 mg/100 g, while was equally in both the seed and pulp. It was found that all grape samples were rich in phenolic compounds and had antioxidant activity. Conclusion: It was clear that antioxidant capacity and phenolic profile of samples changes according to grape species and cultivars.

    • SDG 2 · Açlığa Son
    AtıfScopus11WoS7OpenAlex10
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2023Scopus SJRQ1
    Physicochemical Characterization of Dextran HE29 Produced by the Leuconostoc citreum HE29 Isolated from Traditional Fermented Pickle

    İspirli, Hümeyra

    In this study, lactic acid bacteria (LAB) strains were isolated from traditional fermented pickles, and among the identified strains, Leuconostoc citreum HE29 with a strong slimy colony profile was further selected to determine the physicochemical and techno-functional properties of its exopolysaccharide (EPS). Glucose was the only sugar monomer in the core unit of EPS HE29 detected by HPLC analysis, and glucan HE29 revealed 7.3 kDa of molecular weight. Structural characterization of glucan HE29 by 1H and 13C NMR spectroscopy analysis demonstrated that EPS HE29 was a dextran-type EPS containing 5.3% levels of (1 → 3)-linked α-D-glucose units. This structural configuration was also supported by FT-IR analysis, which also demonstrated the functional groups within the dextran HE29 structure. In terms of thermal properties detected by TGA and DSC analysis, dextran HE29 demonstrated a degradation temperature of around 280 °C, showing its strong thermal features. A semi-crystalline nature was observed for dextran HE29 detected by XRD analysis. Finally, AFM and SEM analysis revealed tangled network-like properties and web-like branched structures for dextran HE29, respectively. These findings suggest the importance of plant-based fermented products as LAB sources in obtaining novel EPS structures with potential techno-functional roles.

    AtıfScopus10WoS9OpenAlex11
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2023Scopus SJRQ1
    A new approach for high-quality production of UHMWPE by applying powder vibration densification before sintering

    Yilmaz, Galip; Uslu, Emin

    Due to its extreme viscosity, UHMWPE powder requires elevated pressure and temperature settings to ensure a fully solid structure. But a gentle process is vital for reliability in certain applications, such as prosthetic liners. A unique type of large gap, not mentioned in the literature, has been observed to resist closing more than regular gaps due to the number of particles forming a shield against pressure. As a solution, a mechanical vibration treatment of the particles before heating was used to eliminate these particular large gaps. Optimum vibration parameters were found, and the samples' final solid density and mechanical properties increased. The particles' dimensions and coefficient of friction were measured, and their vibration-dependent characteristics were discussed. A custom-made microscope apparatus was used to observe the vibration-induced densification of the particles and the gaps resisting closing.

    AtıfScopus14WoS14
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2023Scopus SJRQ3
    Fatḥ al-Raḥīm al-Raḥmān fī tafsīr Āyat "inna Allāha yaʼmuru bi al-ʻadl wa al-iḥsān" by Abū al-Ḥasan b. ʻAbd al-Raḥmān b. Muḥammad al-Khaṭīb al-Shirbīnī al-Shāfiʻī: Study and Critical Edition; [Ebü’l-Ḥasen b. ʻAbdirraḥmān İbn Muḥammed el-Ḥaṭīb eş-Şirbīnī eş-Şāfiʻī’nin Fetḥu’r-Raḥīmi’r-Raḥmān fī tefsīri Āyeti "innallāhe yeʼmuru bi’l-ʻadli ve’lİḥsān" adlı eseri: İnceleme ve Tahkik]

    Aras, Zakir

    This study seeks to investigate the treatise of Abū al-Hasan b. Abd al-Rahman b. Muhammad al-Khatīb al-Shirbīnī al- Shāfiʻī (d. after 1028/1619) entitled Fatḥ al-Raḥīm al-Raḥmān fī tafsīr Āyat "inna Allāha yaʼmuru bi al-ʻadl wa al-iḥsān" based on the manuscript of the author. Shedding light on the translation of this unknown scholar, as it is evident from the title of the treatise that it contains the interpretation of this verse, which is well known among scholars and commentators as the most comprehensive verse in the Qur’ān. In this tafsīr, Shirbīnī used many exegetical methods such as exegesis of the Qur'ān with the Qur'ān, exegesis of the Qur'ān with the Sunnah, exegesis of the Qur'ān with the sayings of the Companions, and al-tafsīr bi-al-raʼy, as well as tafsīr approaches such as linguistic tafsīr, the science of munāsabāt, and causality of nuzūl to analyze the meanings of the verse in depth. Another feature that increases the importance of this treatise is that al-Shirbīnī refers to the primary source tafsīr books together with their glosses, sometimes quoting from the commentators verbatim, and sometimes making meaning-based quotations from them, which is the most obvious indication of his exegetical ability and scholarly competence. In this work, he adopted a syncretic approach while emphasizing the meanings of the verse and followed an analytical-critical method while examining the subject. For this reason, he analyzed all the words in the verse one by one, dwelt on the meanings and interpretation of the words, and criticized their views after including the views of the commentators. Therefore, he applied the analytical exegesis method very successfully in this work. Accordingly, he analyzed the narrations related to tafsīr and mentioned the Companions' names during the narration. In particular, he analyzed the narrations from Ibn 'Abbas (d. 68/687-88) about the words al-ʻAdl and al-iḥsān, and stated that there was a dispute between the narrations about the phrase al-iḥsān. He took a scientific stance on the derivation of the word "Allah,” debated between those who accepted it and those who rejected it. He stated that the derivation of the word was not satisfactory and reliable. In the tafsīr of the words al-ʻAdl and al-iḥsān, he discussed the isnāds in Muqātil b. Sulayman’s (d.150/767) tafsīr emphasizing that he received the tafsīr of al-ʻAdl from Ibn 'Abbas and the tafsīr of al-iḥsān from 'Ali b. Abī Tālib. This approach is an important example for the isnād analyses of Muqātil b. Sulayman who was criticized for neglecting isnād chains in his tafsīr. He also criticized al-Baydāwī for being influenced by some of Zamakhsharī's sectarian and theological views. He classified the issue of kinship according to usūl, furū', and hawāshī, expanded the meaning of the verse, and insisted that the message of this verse encompasses all relatives, regardless of the degree of kinship. He was influenced by Latāʾif al-Ishārāt, al-Kashshāf, Mafātīhu al-ghayb, al-Baydawī, Hāshiya al-Jurjānī ala al-Kashshāf, and his grandfather al-Khatīb al-Shirbīnī’s (d.977/1570) al-Sirāj al-munīr.

    AtıfOpenAlex2
    ScopusWeb of ScienceTR Dizinİncele
  • MakaleAçık Erişim2023Scopus SJRQ1
    Diversity of Clostridium spp. causing late blowing in Kaşar cheese and their behaviour against various antimicrobials

    Kaya, Halıl Ibrahim; Simsek, Omer; Akgunoglu, Ozlem

    One of the problems encountered during storage of Kaşar cheese is blowing. The diversity of Clostridium spp. having a role in blowing was screened and the sensitivity of Clostridium spp. strains against nisin, NaCl, CuSO4, and EDTA was determined and compared. According to 16S rDNA sequence similarity, 12 Clostridium spp. isolates were Clostridium sporogenes while 3 were Clostridium jeddahense. Gas formation by Clostridium spp. spores can be significantly inhibited by reducing the pH below 5.5 and adding 400 IU mL−1 nisin when the number of spores are below 300 spore mL−1. It was determined that the late-blowing problem in Kaşar cheese is caused by C. sporogenes and C. jeddahense strains, but the success of preventive agents is closely related to the amount of spores.

    • SDG 2 · Açlığa Son
    AtıfScopus7WoS4OpenAlex6
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2023Scopus SJRQ2
    Efficient bioreduction of 1-(furan-2-yl)ethanone into enantiomerically pure drug precursor by Lactobacillus paracasei BD101

    Şahin, Engin

    Asymmetric bioreduction catalyzed by biocatalyst have shown considerable potential in the preparation of chiral alcohols. (R)-1-(furan-2-yl)ethanol ((R)-2) can be used precursor in the synthesis of many naturally bioactive piperidine alkaloids such as (−)-Cassine, (−)-Spectaline, (−)-Carnavaline, Prosafrine and (−)- Prosafrinine. Moreover, (R)-2 a key chiral precursor in the production of α, β-unsaturated δ- lactones, which have antifungal, antibiotic, and cytotoxic effects on human tumor cells. However, the synthesis routes of (R)-2 still pose significant challenges in term of unsatisfactory enantiomeric excess (ee) and gram scale synthesis. In this study, Lactobacillus paracasei BD101 biocatalyst from boza, a cereal-based fermented beverage, for the asymmetric bioreduction of the 1-(furan-2-yl)ethanone (1). Following biocatalytic process optimization, (R)-2 was generated with >99% ee and 97% yield. In addition, 9.9 g of 1 was completely converted into (R)-2 on a gram scale (9.78 g, 97% isolated yield) in 48 h. This is the first report about the fabrication of enantiopure (R)-2 in high gram scale using biocatalyst. The optical purity of (R)-2 produced by asymmetric reduction with L paracasei BD101 was also noteworthy since it was the highest documented to date. This study provides an efficient green process for the biocatalytic synthesis of (R)-2.

    AtıfScopus16WoS15OpenAlex14
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2023Scopus SJRQ1
    Investigation of vibration performance of pure active single and multi-feedback controls for a tall RC building

    Uyar, Mehmet; Ergün, Mustafa

    Structural control methods are applied to eliminate the structural damages caused by the vibrations in the buildings and to improve their dynamic behavior of them under dynamic lateral loads. In this paper, the pure active control performance of a tall building under the influence of earthquake records, in which the effective time duration is determined by considering the ARIAS energy distribution, is presented. The building's pure active control performance in the period when the earthquake records have the maximum effect on the structure is examined. Eleven earthquake records are selected to better evaluate the effect of vibration control performance. A genetic algorithm is used to determine the parameters of single and multi-feedback controllers, and its effect on the vibration eliminations at the top and all floors is studied. Also, the effect of displacement and velocity feedback on seismic vibration control is evaluated. To carry out the vibration control studies of the building, the mathematical model is extracted from the finite element model created in ANSYS and verified with finite element analysis. It is observed that the displacement value at a reference location on the building is reduced from 0.735 m to 0.019 m, 0.004 m, and 0.002 m, respectively, by the Proportional-Integral-Derivative, Direct Velocity Feedback, and Optimal controllers. The results show that the multi-feedback control is more effective than the single-feedback control application in reducing the vibration amplitudes at all floors in the pure active control system.

    AtıfScopus6WoS5OpenAlex5
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  • MakaleAçık Erişim2023Scopus SJRQ3
    A STUDY ON THE CONTACT PROBLEM OF A LAYER CONSISTING OF FUNCTIONALLY GRADED MATERIAL (FGM) IN THE PRESENCE OF BODY FORCE

    Adiyaman, Gökhan; Öner, Erdal; Yaylaci, Murat; Birinci, Ahmet

    One of the most important components of the early design process for layered systems is gaining a knowledge of the behavior of materials under varied contact situations. Functionally graded materials (FGMs) have grown in popularity in layered systems as a result of their numerous benefits, such as permitting the reduction of local stress concentrations and thermal stresses often experienced in traditional composites. This paper suggests an analytical approach to solving the continuous and discontinuous contact problems of a functionally graded (FG) layer subjected to a distributed load. Elasticity theory and integral transform methods provide the basis of the aforementioned analytical approach. The FG layer rests on a half-plane that is homogeneous, and there is no adhesion or bonding at the contact surface. For this problem, we assume an exponentially varying shear modulus and mass density in the FG layer. In the solution, the body force of the FG layer is considered. The problem is solved analytically by applying boundary conditions for both continuous and discontinuous contact cases. The presented results show the effects of load factor, amplitude of distributed load, inhomogeneity parameters, and interface material property mismatch on contact stress distributions, initial separation load (critical load), initial separation distance, starting and end point of separation, and separation interval.

    AtıfScopus39WoS40OpenAlex30
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2023Scopus SJRQ2
    EFFECTS OF ARTIFICIAL WEATHERING ON THE SURFACE PROPERTIES OF COATED RADIATA PINE

    Sahin, Sirri; Esteves, Bruno; Can, Ahmet; Sivrikaya, Hüseyin; Domingos, Idalina; Ferreira, José; Ayata, Ümit

    Radiata pine boards were coated with two different methods A and B both beginning with a hydro primer and finishing with a mat oil but method A using an acrylic high gloss coating and method B three layers of an acrylic sealer in between. The samples were subjected to aging processes for 144 h, 288 h, and 432 h by using UV-A 340 nm lamps. The CIE L*a*b* and CIE L*C*H* coordinates were determined (L*, a*, b*, C*, ho*, ΔE*), gloss (perpendicular (⊥) and parallel (//) to the grain at 20°, 60°, and 85° angles) and surface adhesion strength via the pull-off method were tested before and after weathering. Results have shown that lightness (L*), decreases with weathering for both varnish applications with a higher decrease for the B coating system. Redness increased for both applications with no significant differences. At the same time there was a yellowing of the samples along the weathering period. Parallel and perpendicular gloss decreased for 20º and 60º angles while it increased for 85º angle. The adhesion strength of method A was higher and its decrease with weathering was smaller than for method B. Both varnish applications have proven to confer some protection against wood discoloration, but method A showed the best results and is therefore the best method to be used by radiata pine.

    AtıfScopus2WoS2OpenAlex2
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  • MakaleYalnız künye2023Scopus SJRQ3
    Seismic response of adjacent buildings interconnected by viscous dampers considering soil-structure interaction

    Hatipoğlu, Yavuz S.; Düzgün, Oğuz A.

    The effectiveness of fluid viscous dampers (FVDs) on dynamic response mitigation of coupled two adjacent structures was investigated, considering soil-structure interaction (SSI) effects under earthquake excitation. A numerical procedure was employed to evaluate system response. The finite elements were used for the numerical treatment of the adjacent buildings and soil region. Viscous boundary conditions were used as special non-reflecting boundaries on the edges of finite soil region. According to the results, the FVDs were found to be very effective for dynamic response mitigation of the adjacent buildings, even if considering the soil medium. The results showed that the most affecting parameter on the system response was found to be soil type. It was also concluded that when adjacent structures coupled by FVDs, the maximum values of the roof displacements, the base shear forces, and the base bending moments could decrease up to around 50%. Changing in lateral stiffness of the one building has minor effects on the effectiveness of viscous dampers

    • SDG 11 · Sürdürülebilir Şehirler ve Topluluklar
    AtıfScopus5WoS5OpenAlex2
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2023Scopus SJRQ2
    The melatonin agonist ramelteon attenuates bleomycin-induced lung fibrosis by suppressing the NLRP3/TGF-Β1/HMGB1 signaling pathway

    Aydin, Pelin; Aksakalli-Magden, Zeynep B.; Civelek, Maide S.; Karabulut-Uzuncakmak, Sevgi; Mokhtare, Behzad; Ozkaraca, Mustafa; Alper, Fatih; Halici, Zekai

    Purpose: The possible effects of ramelteon, a melatonin receptor agonist on bleomycin-induced lung fibrosis were analyzed via transforming growth factor β1 (TGF-β1), the high mobility group box 1 (HMGB1) and Nod-like receptor pyrin domain-containing 3 (NLRP3) which are related to the fibrosis process. Materials and methods: Bleomycin (0.1 ​mL of 5 ​mg/kg) was administered by intratracheal instillation to induce pulmonary fibrosis (PF). Starting 24 ​h after bleomycin administration, a single dose of ramelteon was administered by oral gavage to the healthy groups, i.e. PF ​+ ​RM2 (pulmonary fibrosis model with bleomycin ​+ ​ramelteon at 2 ​mg/kg) and PF ​+ ​RM4 (pulmonary fibrosis model with bleomycin ​+ ​ramelteon at 4 ​mg/kg) at 2 and 4 ​mg/kg doses, respectively. Real-time polymerase chain reaction (real-time PCR) analyses, histopathological, and immunohistochemical staining were performed on lung tissues. Lung tomography images of the rats were also examined. Results: The levels of TGF-β1, HMGB1, NLRP3, and interleukin 1 beta (IL-1β) mRNA expressions increased as a result of PF and subsequently decreased with both ramelteon doses (p ​< ​0.0001). Both doses of ramelteon partially ameliorated the reduction in the peribronchovascular thickening, ground-glass appearances, and reticulations, and the loss of lung volume. Conclusions: The severity of fibrosis decreased with ramelteon application. These effects of ramelteon may be associated with NLRP3 inflammation cascade.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus9WoS9OpenAlex8
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2023
    Effects of bleaching chemicals on some surface characteristics of olon (Zanthoxylum heitzii) wood; [Olon (Zanthoxylum heitzii) odununun bazı yüzey özellikleri üzerine ağartıcı kimyasalların etkileri]

    Peker, Hüseyin; Ayata, Ümit

    Olon wood is used internationally in plywood, furniture, interior carpentry, and mold making. In this study, the effects of wood bleaching chemicals (oxalic acid and H2O2+NaOH) on certain surface properties (color, glossiness, and whiteness index: WI*) of olon wood (Zanthoxylum heitzii) were investigated. The results of the bleached samples were compared with those of a control group. Based on the results obtained, it was determined that the variance analyses conducted for all tests in the study yielded statistically significant results. Application of both bleaching chemicals led to an increase in the ho and L* values. The ∆E* values were determined as 2.07 for the single-component and 10.30 for the double-component. In contrast, these parameters increased with the single-component bleach while the a*, b* and C* values decreased with the double-component wood bleach. The WI* values exhibited an increase in both directions when they were exposed to both bleaching chemicals. Both bleaching agents resulted in reductions in glossiness values at 85 degrees in both directions. Furthermore, there were declines with the single-component bleach and rises with the double-component bleach when measuring glossiness at 60 degrees in both directions.

    AtıfScopus3OpenAlex4TR Dizin2
    ScopusTR Dizinİncele
  • MakaleYalnız künye2023Scopus SJRQ1
    Parameter extraction method for reflection-asymmetric bianisotropic metamaterial slabs using one-port measurements

    Hasar, Ugur Cem; Kaya, Yunus; Ozturk, Hamdullah; Ertugrul, Mehmet; Ramahi, Omar Mustafa

    An effective microwave method is developed for extracting electromagnetic properties of bianisotropic metamaterial (MM) slabs. As a non-iterative method, it utilizes only the one-port (air-backed and metal-backed MM slab) scattering (S-) parameter measurements. This is a useful feature especially for vector network analyzers, such as MS46131A, MS46121B, and R60, performing only one-port S-parameter measurements. Electromagnetic properties of a bianisotropic MM slab formed by C-shaped resonators are measured by an X-band (8.2–12.4 GHz) rectangular waveguide setup. The effect of any gap between the short-circuit termination for metal-backed measurements and the end of the MM slab on extracted electromagnetic properties is also examined for evaluating the possible error for proposed method.

    AtıfScopus3WoS3OpenAlex5
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2023Scopus SJRQ2
    Suberosin Alleviates Sepsis-Induced Lung Injury in A Rat Model of Cecal Ligation and Puncture

    Karabulut Uzunçakmak, Sevgi; Halıcı, Zekai; Karakaya, Songül; Kutlu, Zerrin; Sağlam, Yavuz Selim; Bolat, İsmail; Aydın, Pelin; Kılıç, Ceyda Sibel

    Background/aims: Sepsis is one of the major problems encountered in intensive care units, causing organ damage and increasing mortality. Suberosin (SBR) is a type of coumarin with antioxidant and anti-inflammatory activities. The goal of this study is to explore the protective effects of SBR on the lungs in a rat model of sepsis. Methods: Male Wistar rats were utilized in this study. A cecal ligation and puncture (CLP) model was applied to induce sepsis. Rats were separated into six groups with nine animals in each group, including healthy control, SBR, CLP, and CLP + SBR (5, 10, and 20 mg/kg) groups. Superoxide dismutase (SOD), glutathione (GSH) enzyme activities, and malondialdehyde (MDA) level were measured via enzyme-linked immunosorbent assay (ELISA). The messenger RNA (mRNA) expressions of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) were evaluated by real-time polymerase chain reaction (RT-PCR). Histopathological changes in the lungs were investigated with hematoxylin and eosin (H&E). Results: MDA levels and GSH and SOD enzyme activities were negatively affected in the CLP group, but SBR treatment ameliorated these oxidative stress parameters in the SBR1-3 groups (p< 0.05). The mRNA expressions of TNF-α and IL-1β were increased in the CLP group, and SBR treatment decreased those expression levels in a dose-dependent manner (p < 0.05). Organ damage and necrosis were seen in the CLP group and were alleviated in the SBR3 group. Immunohistochemical (IHC) analysis of lung tissues demonstrated decreased TNF-α and IL-1β immunopositivity in the SBR1-3 groups (p< 0.05). Conclusions: SBR ameliorated sepsis-related lung injury in a dose-dependent manner. This compound has significant potential as a future agent in the treatment of sepsis.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus15WoS11OpenAlex15
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2023Scopus SJRQ3
    A Study on YouTube Channels of Foreign Languages Teaching Foundation

    Maden, Sedat; Kaya, Musa

    This study was conducted to examine the YouTube channels of Yunus Emre Institute, British Council, Institut Français, Instituto Cervantes, Confucius Institute and Goethe Institut foundations having channels on YouTube, one of the largest video sharing platforms of the world. The channels in this study, were examined through the qualitative research method in terms of the upload date, the numbers of subscribers, the numbers of videos, the videos’ grouping status, the number of video views, and the features of the most watched videos. As a result of the study, it appears that Yunus Emre Institute created its YouTube channel in 2014, British Council in 2010, Institut Français in 2017, Instituto Cervantes in 2017, Confucius Institute (U.S.) in 2017 and Goethe Institute in 2007. Yunus Emre Institute, one of the channels on YouTube, has more than 64400 subscribers, British Council has 542000, Institut Français has 3650, Instituto Cervantes has 69100, Confucius Institute has 801, and Goethe Institute has 301000. It is found that Yunus Emre Institute has 925, British Council has 134, Institut Français has 463, Instituto Cervantes has 1115, Confucius Institute has 82, and Goethe Institute has 1152 videos on YouTube. It has been determined that YouTube channels belonging to institutions established to teach the world's most spoken languages were created adopting similar paradigms and after the year 2007.

    • SDG 4 · Nitelikli Eğitim
    AtıfScopus1OpenAlex1
    Scopusİncele