Yazarlar
- Bayraktar, Bülent(33)
- Dertli, Enes(33)
- Dirican, Ebubekir(20)
- Akeren, Zahide(18)
- İspirli, Hümeyra(18)
- Kizil, Hamit Emre(17)
- Semerci, Vahide(14)
- Bayram, Sinan(13)
- Kul, Murat(13)
- Sönmez Sarı, Ebru(13)
- Agar, Guleray(12)
- Akman, Onur(12)
- Kırbaş, Zila Özlem(12)
- Akeren, İhsan(11)
- Koçak, Lokman(11)
- Makas, Samet(11)
- Can, Zehra(10)
- Uzunçakmak, Sevgi Karabulut(10)
- Yayla, İbrahim Erdoğan(10)
- Çelik, Eyüp(10)
- Bayraktar, B.(9)
- Bulbuloglu, Semra(9)
- Kızıl, Hamit Emre(9)
- Tekce, Emre(9)
- Aydemir, Uğur(8)
- Daştan, Buket(8)
- Hintistan, Sevilay(8)
- Kalyoncuo, Servet(8)
- Sönmez Sari, Ebru(8)
- Türkmen, Mutlu(8)
- Apaydın, Emine(7)
- Arslaner, Ayla(7)
- Beydemir, Şükrü(7)
- Dombak, Kübra(7)
- Kara, Yakup(7)
- Mercan, Emin(7)
- Semerci Çakmak, Vahide(7)
- Can, Özgür Devrim(6)
- Esgin, Özge(6)
- Güneş, Hüseyin(6)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ2Diagnostic and Prognostic Significance of miR-155, miR-181, miR-221, miR-222, and miR-223 Expression in Myelodysplastic Syndromes and Acute Myeloid Leukemia
Ardıç, Cemile; Ay, Mustafa Ertan; Çevik, Kenan; Tombak, Anıl; İzci Ay, Özlem; Karakaş, Ümit; Doğru Özdemir, Gurbet; Bilgiç, Abdulkadir; Erdal, Mehmet Emin
Background: Myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) are clonal hematological disorders that share molecular origins but present with distinct clinical features. MicroRNAs (miRNAs) are key post-transcriptional regulators, and their altered expression may reflect biological shifts contributing to disease progression. Methods: Expression levels of miR-155, miR-181, miR-221, miR-222, and miR-223 were analyzed by RT-qPCR in bone marrow samples from 37 MDS patients, 20 AML patients, and 7 controls. Group comparisons were performed using ANOVA (with Benjamini–Hochberg correction) and Tukey post hoc testing. Diagnostic performance and network behavior were evaluated using ROC analysis, Pearson correlation matrices, and principal component analysis (PCA). Results: miR-155, miR-181, and miR-223 were upregulated in AML, whereas miR-221 and miR-222 were downregulated. miR-222 showed the highest diagnostic accuracy (AUC ~0.87 for both AML vs. control and MDS vs. control). Its expression was significantly higher in high IPSS-R MDS cases (p = 0.046), with a similar upward tendency for miR-221 (p = 0.054). Progressive loss of coordinated miRNA expression was observed from controls to MDS and AML. PCA supported these findings by showing separation mainly driven by miR-222 and miR-155. Conclusions: Combined miRNA profiling highlights miR-222 and, to a lesser extent miR-155, as consistent indicators of myeloid disease transformation. While further validation in larger and genetically stratified cohorts is warranted, these findings support the potential contribution of miRNA signatures to diagnostic evaluation and risk stratification in MDS and AML, in line with precision hematology approaches.
AtıfScopus1WoS1OpenAlex1
İncele - MakaleYalnız künye2026Scopus SJRQ2Self-regulation in blood glucose management among middle-aged and older adults with type 2 diabetes in a rural and semi-rural setting: A qualitative study
Akeren, İhsan; Akeren, Zahide
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with increasing prevalence, particularly among middle-aged and older adults. Effective blood glucose management is essential for preventing complications and improving quality of life. Although self-regulation has been widely examined in diabetes management, little is known about how middle-aged and older adults living in rural and semi-rural settings apply self-regulation strategies in daily life. This qualitative study explored the blood glucose management experiences of individuals aged 50 years and older with T2DM using Zimmerman’s cyclical self-regulated learning model. Face-to-face interviews were conducted with 16 hospitalized participants meeting the rural or semi-rural residence criterion. Data were analyzed using an inductive-deductive hybrid thematic approach and organized with MAXQDA 20. Three main themes and 13 subthemes were identified: preparation and awareness, barriers and management behaviors, and self-evaluation and internal awareness. During the forethought phase, participants described knowledge, motivation, awareness, and planning but also reported misconceptions about diet and blood glucose management. In the performance phase, behavioral, emotional, cognitive, and social barriers, comorbidities, and poor adherence to dietary recommendations were common. During self-reflection, participants recognized physical symptoms and emotional influences but rarely reported systematically evaluating outcomes or modifying subsequent management behaviors. The findings indicate that inadequate knowledge, emotional challenges, comorbidities, limited social support, and ineffective coping strategies may disrupt the cyclical self-regulation process. Educational interventions for middle-aged and older adults in rural and semi-rural settings should strengthen knowledge, support self-management behaviors, and promote evaluation of outcomes and adaptation of future actions.
- MakaleAçık Erişim2026Scopus SJRQ2Bioinspired Sternal Implant Design for Generic Anatomical Reconstruction: An In Silico Framework for Material Selection and Biomechanical Validation
Kutbay, Işıl; Gerdan, Zeynep; Çolak, Murat; Tabak, Yasemin; Şensoy, Abdullah Tahir
The sternum protects the intrathoracic organs and contributes to chest wall mechanics, which makes reconstruction after tumor resection, trauma, or infection a demanding biomechanical problem. This study presents an in silico workflow for preselecting materials for sternal implants before physical prototyping. After a virtual resection, an anatomically conformal implant was designed and candidate biomaterials were screened in CES Selector using density, elastic modulus, fatigue strength, fracture toughness, toxicity, medical grade suitability, and MRI safety. A representative subset of the screened candidates was then compared by finite element modeling in terms of stress transfer and deformation. Seventeen candidates met the screening criteria. Ti-13Nb-13Zr showed an elastic modulus of about 80 GPa, and the titanium-based candidates showed deformation values of about 0.96 to 1.03 mm, whereas GF PEEK reached about 1.74 mm. The stress shielding index also showed that titanium-based materials remained on the implant-dominant side, while polymer-based materials shifted stress transfer toward bone. Taken together, the findings suggest that Ti-13Nb-13Zr offers the best overall balance for load-bearing sternal reconstruction, whereas PEEK-based systems may be more suitable within the present model for hybrid or adjunct designs. The proposed workflow can support early implant planning and guide future experimental and clinical studies.
- MakaleAçık Erişim2026Scopus SJRQ2Deep Learning-Based Classification of Common Lung Sounds via Auto-Detected Respiratory Cycles
Engin, Mustafa Alptekin; Uzun Arslan, Rukiye; Senyer Yapici, İrem; Aras, Selim; Gangal, Ali
Chronic respiratory diseases, the third leading cause of mortality on a global scale, can be diagnosed at an early stage through non-invasive auscultation. However, effective manual differentiation of lung sounds (LSs) requires not only sharp auditory skills but also significant clinical experience. With technological advancements, artificial intelligence (AI) has demonstrated the capability to distinguish LSs with accuracy comparable to or surpassing that of human experts. This study broadly compares the methods used in AI-based LSs classification. Firstly, respiratory cycles—consisting of inhalation and exhalation parts in LSs of different lengths depending on individual variability, obtained and labelled under expert guidance—were automatically detected using a series of signal processing procedures and a database was obtained in this way. This database of common LSs was then classified using various time-frequency representations such as spectrograms, scalograms, Mel-spectrograms and gammatonegrams for comparison. The utilisation of proven, convolutional neural network (CNN)-based pre-trained models through the application of transfer learning facilitated the comparison, thereby enabling the acquisition of the features to be employed in the classification process. The performances of CNN, CNN and Long Short-Term Memory (LSTM) hybrid architecture and support vector machine methods were compared in the classification process. When the spectral structure of gammatonegrams, which capture the spectral structure of signals in the low-frequency range with high fidelity and their noise-resistant structures, is combined with a CNN architecture, the best classification accuracy of 97.3% ± 1.9 is obtained.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2026Scopus SJRQ1Cognitive improvement and hippocampal BDNF/GFAP alterations by Schinus molle essential oil in a rat model of scopolamine-induced amnesia
Üçel, Umut İrfan; Kandemi̇r, Ümmühan; Yazici, Cevşen; Bi̇lgi̇n, Öznur; Turan Yücel, Nazlı; Özek, Temel; Demi̇r Özkay, Ümide; İşcan, Gökalp; Can, Özgür Devrim
Ethnopharmacological relevanceSchinus molle L. (Anacardiaceae) has been traditionally used for conditions related to the nervous system and emotional well-being, often through aromatic preparations. However, its cognition-specific effects have not yet been investigated.Aim of the studyTo assess the cognitive effects of the fruit-derived essential oil of Schinus molle L. (SMEO), administered via oral and inhalation routes, in a rat model of scopolamine-induced amnesia.Materials and methodsSMEO was obtained by hydrodistillation and characterised by GC–MS/GC–FID. Amnesic rats received SMEO for 14 days by inhalation (1% or 3%) or oral gavage (100 or 200 mg/kg). Cognition was assessed by Morris water maze (MWM), passive avoidance (PA), and novel object recognition (NOR) tests; locomotion was measured by activity-meter. Hippocampal BDNF and GFAP immunoreactivity were assessed by immunohistochemistry.ResultsSMEO was dominated by α-phellandrene (48.7%). Scopolamine impaired cognition, whereas SMEO attenuated deficits with efficacy comparable to piracetam. Key behavioural and immunohistochemical findings (main omnibus statistical effects) were as follows: In the MWM, treatment and time effects on escape latency were significant (both p < 0.001), and probe performance improved (p < 0.001). PA retention was restored (p < 0.001) and the NOR index improved (p < 0.001), without locomotor changes (all p > 0.05). Scopolamine reduced hippocampal BDNF immunoreactivity in CA1 and DG (p < 0.01) and CA3 (p < 0.001), which was restored by SMEO via both routes. GFAP immunoreactivity was reduced in CA1/CA3/DG (all p < 0.001) and was rescued selectively after inhalation.ConclusionsThese findings provide preclinical evidence consistent with an ethnopharmacological rationale for SMEO and support further translational work to clarify its relevance beyond this experimental paradigm.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ2The mediating role of social support in the relationship between social isolation and life satisfaction in families with and without children with special needs
Yayla, İbrahim Erdoğan; Turhan, Fatma Seher; Dombak, Kübra; Makas, Samet; İskender, Murat; Çelik, Eyüp
Objectives: The present study aims to examine the relationships between social isolation, social support, and life satisfaction in parents with and without children with special needs. Methods: The data for this study were obtained from 422 parents with children. Of the participants, 266 (63.0%) were mothers, and 156 (37.0%) were fathers, with an average age of 39.43 (SD = 7.62; range = 22–65). Convenience sampling was used in this study. When examining the marital status distribution, 386 participants (91.5%) were married, and 36 (8.5%) were single. Furthermore, 203 parents (48.1%) stated that they had a child with special needs, while 219 (51.9%) stated that they did not have a child with special needs. Results: The correlation analysis revealed that all variables are related to each other. Furthermore, structural equation modeling results showed that social support plays a mediating role in the relationship between social isolation and life satisfaction. Conclusions: This research evaluates parents with and without disabled children in terms of social isolation, social support, and life satisfaction, and indicates that social support is significantly more important for parents with disabled children compared to those without.
- MakaleYalnız künye2026Scopus SJRQ2Multi-Pathway Renoprotection by Betanin Against Docetaxel Nephrotoxicity: Modulation of Inflammation, ER Stress, Apoptosis, and Ferroptosis
Süzen Celbek, Büşra; Akaras, Nurhan; Şimşek, Hasan; Mutlu, Hüseyin; Kızıl, Hamit Emre; Kandemir, Özge; Aygörmez, Serpil; Kandemir, Fatih Mehmet
Docetaxel (DTX), a cornerstone chemotherapeutic agent, has its clinical utility significantly limited by dose-dependent nephrotoxicity. This study investigated the multi-pathway renoprotective mechanisms of betanin (BTN), a natural antioxidant derived from beetroot, against DTX-induced kidney injury. Male Wistar rats received DTX (30 mg/kg, i.p., single dose) with or without BTN (100 mg/kg/day, p.o.) for 7 days. DTX induced severe renal dysfunction with elevated serum urea and creatinine, and significant oxidative stress characterized by increased MDA and decreased GSH, GPx, SOD, and CAT. Molecular analysis demonstrated widespread upregulation of pro-inflammatory (NF-κB, TNF-α, IL-1β), endoplasmic reticulum stress (PERK, ATF6), pro-apoptotic (Caspase-3, Bax, Apaf-1), and pro-ferroptotic (PTGS2, TfR1) mediators, with concurrent downregulation of protective Bcl-2 and GPx4. Histopathological examination revealed extensive tubular injury, while immunohistochemical analysis showed markedly increased kidney injury marker KIM-1 and decreased aquaporin-1 expression. Remarkably, BTN co-administration significantly attenuated all biochemical, molecular, and structural derangements, restored tissue architecture, and normalized KIM-1 and AQP-1 expression. In conclusion, betanin provides robust, multi-pathway renoprotection against docetaxel-induced nephrotoxicity by concurrently targeting oxidative stress, inflammation, ER stress, apoptosis, and ferroptosis.
- MakaleYayıncıda açık erişim2026Scopus SJRQ1Social Media Interaction Motivation Scale: Development and Relations with Fear of Missing Out, Phubbing, Social Media Disorder, Gender and Time Spent
Akeren, İhsan; Koçak, Lokman; Özgöl, Mustafa; Demir, Mustafa
Social media, which is one of the platforms where online activities are most intensely observed, has become an indispensable element of daily life as it enables individuals to interact. The aim of this three-phase study was to develop a measure of social media interaction motivation (SMIM) among those who use at least one of these platforms, to test its validity and reliability, and then to examine its relationship with some variables that were found to be similar. SMIM increases unhealthy cyber behaviors such as fear of missing out (FoMO) and phubbing. Comparing the measures across the three studies, the means of SMD, FoMO, and phubbing do not differ by gender, except for the higher SMIMS scores of females in Study 2. However, these means increase dramatically with time spent on social media. Considering some limitations of the study, we present our suggestions for future studies.
AtıfScopus6WoS6OpenAlex8İncele - MakaleAçık Erişim2026Scopus SJRQ1Nurses’ Ethical Reasoning About Digital Ethical Risks: A Vignette-Elicited Qualitative Study
Bal, Betül; Köroğlu Kaba, Nagihan; Apaydin, Emine
Aim: This qualitative study aimed to explore how nurses reason ethically about potential digital ethical risks arising from the routine use of digital systems in clinical practice and the strategies they propose to address these risks in response to vignette-based scenarios. Background: Digital systems shape nursing documentation, monitoring, communication, education, and decision-making. Although they support care, digital ethical risks may arise when digital outputs are accepted without clinical verification, patients are not adequately informed, or data protection is weak. Design: A vignette-elicited qualitative design was used. Methods: The study was conducted in September 2025 with 16 nurses working in three public hospitals in Central Anatolia, Türkiye. Data were generated through face-to-face interviews using seven vignette-based scenarios and analyzed using Braun and Clarke's reflexive thematic analysis. Results: Three main themes were generated through the analysis of nurses’ ethical reasoning in response to the vignette-based scenarios: (i) nurses’ purposes for using digital systems, (ii) digital ethical risks in nursing, and (iii) strategies to prevent digital ethical risks. The findings within Themes 2 and 3 were organized into four subthemes—nonmaleficence and beneficence, autonomy and respect for persons, justice and equity, privacy and confidentiality—and further structured across three researcher-developed categories: nurse, digital system, and organization. Conclusions: Participants’ interpretations of the vignette-based scenarios highlighted potential digital ethical risks that may require nurses to combine clinical judgment with ethical reasoning when using digital systems. Implications for Nursing: Participants’ responses may inform digital ethics education by highlighting the importance of verifying digital data through bedside assessment, questioning potentially unsafe digital outputs, protecting confidentiality, obtaining meaningful consent, and recognizing potential risks in documentation, alarms, communication, and data sharing. Implications for Health Policy: Participant-identified priorities may inform institutional consideration of protocols for documentation, alarm management, mobile communication, image sharing, access control, patient information, accessibility, and accountability in digital nursing care.
- MakaleAçık Erişim2026Scopus SJRQ3Supportive Care Needs and Nursing Care Perceptions in Cancer Patients Receiving Targeted Therapies and Immunotherapy: A Cross-Sectional Study
Doğan, Nurhan; Tekinsoy Kartın, Pınar; Kalyoncuo, Servet
Objective: This study was conducted to determine the supportive care needs of cancer patients undergoing targeted therapies and immunotherapy as well as their perceptions of nursing care. Methods: In this study, a cross-sectional research design, a quantitative research method, was used. The study was conducted with 210 individuals between 04.10.2021 and 28.02.2022. In the study, data were collected using the Individual Description Form, Supportive Care Needs Scale (SCNS-SF), and Patients’ Perception of Nursing Care Scale (PPNCS). Results: Individuals with a mean age of 59.18±12.53 years had a SCNS-SF mean score of 121.42±11.80, and a PPNCS mean score of 23.41±10.64. In the study, a significant difference was found between individuals' needs and care perceptions in terms of gender, educational level, cohabitants, working status and disease stage (P<.05). There is no significant correlation between the PPNCS total score and the SCNS-SF total score (r=-.03, P=.653). Conclusion: It was determined that the care needs of the individuals were moderate to high, and their perceptions of nursing care (degree of expected needs and patient satisfaction) were low.
- MakaleAçık Erişim2026Scopus SJRQ1Progressive Smartphone Restriction Combined with Psychoeducational Guidance and Pre-Sleep Autonomic Regulation Improves Sleep Efficiency and Time-of-Day Cognitive Performance in Physically Active Students with Nomophobia: A Randomized Controlled Trial
Alaya, Wiem Ben; Dhahbi, Wissem; Souissi, Mohamed Abdelkader; Jebabli, Nidhal; Ceylan, Halil İbrahim; Ceylan, Nagihan Burçak; Muntean, Raul Ioan; Souissi, Nizar
Aim: This study compared the effects of standard evening smartphone restriction with an adapted intervention combining progressive restriction, psychoeducational guidance, and pre-sleep relaxation on sleep, psychological state, cognitive performance, and physical performance in physically active physical education students with moderate-to-high nomophobia. Methods: Thirty participants (age 21.9 ± 1.2 years; intermediate chronotype) completed a randomized controlled trial consisting of a 7-day baseline period, a 14-day intervention phase, and post-intervention assessments. The standard group (n = 15) implemented a 2-h pre-bedtime smartphone restriction combined with general sleep hygiene guidance. The adapted group (n = 15) followed a progressive restriction protocol (30→60→120 min) supplemented with psychoeducational guidance targeting smartphone-related anxiety and a nightly slow-paced breathing routine. Objective sleep parameters were quantified using wrist-worn actigraphy. Subjective sleep quality, pre-sleep anxiety, and stress were assessed using visual analog scales. Cognitive performance (psychomotor vigilance task and choice reaction time) and physical performance (vertical jumps and agility) were evaluated at both morning and afternoon time points. Results: The adapted intervention produced significantly greater improvements in sleep efficiency (time × group: F(1,28) = 6.84, p = 0.014, ηp2 = 0.20; d = 0.78) and sleep onset latency (F(1,28) = 5.97, p = 0.021, ηp2 = 0.18; d = 0.72) compared with standard restriction. Significant reductions were also observed in pre-sleep anxiety (F(1,28) = 7.12, p = 0.012, ηp2 = 0.20; d = 0.81) and stress (F(1,28) = 6.45, p = 0.017, ηp2 = 0.19; d = 0.74). Cognitive performance showed significant time × group × time-of-day interactions, with improvements during afternoon assessments in psychomotor vigilance (F(1,28) = 7.48, p = 0.011; d = 0.83) and choice reaction time (F(1,28) = 6.89, p = 0.014; d = 0.79) exclusively in the adapted group. Physical performance outcomes remained stable across interventions. Conclusions: Progressive smartphone restriction combined with psychoeducational strategies and pre-sleep relaxation yields clinically meaningful improvements in sleep continuity, psychological arousal, and afternoon cognitive performance, exceeding the benefits achieved through behavioral restriction alone.
AtıfScopus1WoS1OpenAlex2İncele - MakaleAçık Erişim2026Scopus SJRQ4The Validity and Reliability Study of the Turkish Version of the E-Learning Satisfaction Scale
Karaman Özlü, Zeynep; Günaydinli, Azime; Kaya, Merve; Uçan, İzzet; Taşgin, Adnan; Özlü, İbrahim; Küçükoğlu, Adnan; Saraçoğlu, Ayhan
Objective: With the widespread adoption of e-learning during the COVID-19 pandemic and advances in internet technology, the need for a validated tool to assess student satisfaction has become increasingly important. This study aimed to examine the validity and reliability of the Turkish version of the e-Learning Satisfaction Scale (e-LSS). Methods: This cross-sectional, methodological study was conducted with 537 students enrolled in health sciences programs at Erzurum Atatürk University between November 2022 and February 2023. In this study, a non-probability sampling method was used by selecting units that met specific criteria. Content validity was evaluated by expert review of the scale items. Construct validity was assessed through exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Reliability and stability of the scale were tested using the equivalent (parallel) forms method. Results: EFA results showed a Kaiser-Meyer-Olkin value of 0.94 and a significant Bartlett’s test result (χ² = 126.773, p<.001), indicating sample adequacy. Factor loadings ranged from .825 to .354 for the “Content” subscale, .859 to .571 for “Interface,” and .802 to .654 for “Communication.” CFA demonstrated acceptable model fit indices: χ²/df = 4.332, TLI = .915, RMSEA = .079, SRMR = .0481, AGFI = .857, GFI = .896, IFI = .931, and CFI = .930. The final scale consisted of 17 items across 3 subscales. Cronbach’s alpha values were 0.86, 0.86, and 0.83 for the subscales, and 0.93 for the overall scale. Conclusion: The scale was found to be a valid and reliable tool for measuring e-learning.
- MakaleAçık Erişim2026Scopus SJRQ1Assessment of radiological hazards arising from natural radioactivity in Bayburt stones used in buildings and possible effects on public health
Dizman, Serdar; Umar, Muttaka; Hatipoglu, Yavuz Selim
Background – Since ancient times, natural stones have served as essential materials in construction, landscaping, and artistic applications. Bayburt stone is one of the most important stones used in and around Bayburt, in the Eastern Black Sea region of Türkiye. It has been frequently used in buildings (castle, house, etc.), street flooring, fountains, and places of worship from ancient times to the present day. Due to their underground origin, natural stones contain natural radioisotopes in various concentrations, making the assessment of their radioactivity levels important for public health. Objective – This study aims to determine the natural radioactivity levels of Bayburt stones used in buildings and to assess the potential radiological hazards and possible effects on public health. Methods – Natural radioactivity levels (226Ra, 232Th and 40K) were determined in a total of 36 Bayburt stone samples, 30 from five different quarries and 6 from a natural stone factory in Bayburt province. High-purity germanium (HPGe) spectrometry was employed to measure radioactivity concentrations. Additionally, several radiological hazard indices (Raeq, Hin, Iγ, D, AEDE, AGDE, and ELCR) were calculated and compared with reference limits proposed by international organizations. Results – The radioactivity concentrations in the Bayburt stone samples ranged from 1.56 to 23.54 Bq/kg for 226Ra, from 0.53 to 23.69 Bq/kg for 232Th, and from 10.31 to 505.35 Bq/kg for 40K. The average activity concentrations were found to be 5.56 ± 0.90 Bq/kg for 226Ra, 4.62 ± 0.65 Bq/kg for 232Th, and 179.12 ± 9.88 Bq/kg for 40K. The average values of Raeq, Hin, Iγ, D, AEDE, AGDE, and ELCR were found to be 18.68 Bq/kg, 0.07, 0.14, 8.91 nGy/h, 43, 72 μSv/y, 63.06 μSv/y, and 17.07 × 10−5, respectively. All calculated radiological hazard indices were below the recommended safety limits. Conclusion – The findings indicate that the Bayburt stone samples investigated are suitable for construction purposes and do not pose significant radiological hazards to human health when used in building environments.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2026Scopus SJRQ3Frequency spectrum analysis of ground reaction forces during running in individuals with piriformis syndrome following an eight-week neuromuscular training program
Aali, Shirin; Rezazadeh, Farhad; Sheykhalizadeh, Hamed; Qasemi, Mojtaba; Akman, Onur; Badicu, Georgian
Background: Piriformis syndrome, a neuromuscular condition associated with sciatic nerve irritation, can disrupt lower limb biomechanics and alter ground reaction force (GRF) profiles during running. Neuromuscular training may improve lumbopelvic stability and coordination, but its effects on GRF frequency characteristics remain underexplored. Methods: Thirty physically active males (aged 35–45 years) with piriformis syndrome were recruited and allocated to either an intervention group (n = 15) or a control group (n = 15) in this quasi-experimental study. The intervention group completed an eight-week neuromuscular training protocol designed to enhance lumbopelvic stability and coordination. Vertical and free moment GRF components were recorded during treadmill running before and after the intervention. Temporal and group effects were analyzed using a two-way repeated-measures Analysis of Variance (ANOVA). Results: The intervention group exhibited a significant reduction in the number of harmonics in the vertical GRF component (p = 0.003, d = 0.55) and a decrease in the 99.5% power frequency of the free moment component (p = 0.001, d = 0.92). These changes reflected diminished high-frequency oscillations, suggesting improved eccentric muscle function, lumbopelvic control, and neuromuscular coordination. Conclusions: Neuromuscular training resulted in favorable alterations in GRF frequency spectra among individuals with piriformis syndrome, aligning with reductions in pain and indicating more efficient force transfer and load attenuation. These findings support the application of neuromuscular training to optimize running biomechanics and reduce mechanical stress in this population.
- MakaleYalnız künye2026Scopus SJRQ1Perceived Organizational Support and Nurses' Job Performance: The Indirect Roles of Burnout and Quiet Quitting
Koroglu Kaba, Nagihan; Taskiran Eskici, Gülcan; Tiryaki Sen, Hanife
Perceived organizational support is an important organizational resource that may shape nurses' psychological well-being, workplace engagement, and performance-related outcomes. This study examined the relationship between perceived organizational support and nurses' job performance and explored whether burnout and quiet quitting showed indirect associations consistent with mediation. A cross-sectional correlational study was conducted in a tertiary university hospital in the Black Sea Region of Türkiye. Of 980 eligible nurses, 439 responded (response rate: 44.8%); after excluding 14 questionnaires, 425 nurses were included in the final analysis, representing 43.4% of the eligible population. Data were collected using standardized instruments measuring perceived organizational support, burnout, quiet quitting, and individual work performance. Descriptive statistics, Pearson correlation analysis, and multiple mediation analysis using Hayes' PROCESS macro were performed. Perceived organizational support was positively correlated with job performance (r = 0.27, p < 0.001) and negatively correlated with burnout (r = −0.47, p < 0.001) and quiet quitting (r = −0.37, p < 0.001). Burnout (r = −0.31, p < 0.001) and quiet quitting (r = −0.31, p < 0.001) were negatively correlated with job performance. The total effect of perceived organizational support on job performance was significant (b = 0.23, β = 0.27, p < 0.001). The direct association between perceived organizational support and job performance remained significant even after accounting for burnout and quiet quitting (b = 0.10, β = 0.12, p = 0.025). Significant indirect associations were observed through burnout (b = 0.07, β = 0.08, 95% CI = 0.03–0.12) and quiet quitting (b = 0.06, β = 0.07, 95% CI = 0.03–0.09). These findings suggest that supportive organizational environments may be associated with higher job performance among nurses by reducing burnout and quiet quitting. Given the cross-sectional design, these findings should be interpreted as associations consistent with mediation rather than causal evidence. The study was conducted in a single tertiary university hospital in the Black Sea Region of Türkiye, which may limit generalizability to other settings.
- Derleme MakaleAçık Erişim2026Scopus SJRQ2Titanium and polyetheretherketone for spinal fusion cages: a comparative narrative review of material behavior, structural design, and clinical translation
Hasheminasab; Bazmi, Arian; Hamsianetefagh, Rojin; Tabak, Yasemin; Ashkani, Omid; Mahboubizadeh, Shahram; Colak, Murat; Şensoy, Abdullah Tahir
Cage material selection in spinal fusion requires a trade-off among biological fixation, mechanical compatibility, subsidence resistance, and postoperative imaging. This structured narrative review compares titanium and polyetheretherketone (PEEK) cages across seven domains: osseointegration, modulus matching, endplate load transfer, surface biofunctionality, imaging, additive manufacturing and personalization, and geometry-guided architecture. Peer-reviewed literature indexed in PubMed/MEDLINE, Scopus, and Web of Science was considered from database inception through May 2026, with emphasis on comparative clinical studies, systematic reviews, meta-analyses, and mechanistic studies directly relevant to cage design. Preclinical studies favor porous and additively manufactured titanium for bone–implant integration, but a consistent fusion-rate advantage in anterior cervical discectomy and fusion (ACDF) has not been established. In lumbar surgery, lower subsidence has been reported in selected lateral lumbar interbody fusion cohorts, while results after transforaminal lumbar interbody fusion remain heterogeneous. PEEK retains advantages in radiolucency and intrinsic modulus matching, while surface-modified and porous PEEK can improve biological performance. Subsidence is not determined by chemistry alone; cage footprint, architecture, endplate preparation, fixation, and bone quality remain major modifiers. Current evidence therefore supports procedure and design-specific selection rather than universal replacement of either platform. Long-term comparative data and standardized definitions of fusion and subsidence remain limited.
- MakaleAçık Erişim2026Scopus SJRQ3Chemical Profiling and Biological Activities of Methanol Extracts and Essential Oils From Ferulago Platycarpa Boiss. & Balansa (Endemic): Enzyme Inhibition, Antioxidant, and Antimicrobial Properties
Aygül, İmdat; Öz, Mehmet; Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman
This study aimed to evaluate the phytochemical composition and biological activities of Ferulago platycarpa methanol extract (ME) and essential oil (EO). The EO was obtained via hydrodistillation and analyzed by GC-MS, revealing sesquiterpene hydrocarbons as the dominant class, with caryophyllene (65.8%) and α-pinene (9.65%) as the major constituents. The methanol extract was subjected to LC-MS/MS analysis, which identified eleven phenolic compounds, with chlorogenic acid as the most abundant. The extract showed significantly higher total phenolic (1196.22±11.64 mg GAE/100g) and antioxidant (1870.00±17.69 mg QEE/100g) contents compared to the ME. In vitro enzyme inhibition assays demonstrated that the methanol extract exhibited potent inhibitory activity against carbonic anhydrase II (CA-II, ICSO= 0.023 pg/mL), acetylcholinesterase (AChE, ICSO= 110 pg/mL), and butyrylcholinesterase (BChE, IC50= 390 pg/mL). In contrast, the EO showed higher inhibition against α-amylase (IC50= 5920±10.45 pg/mL) and BChE (IC50= 1.32±0.65 pg/mL), while its α-glucosidase showed no inhibition. Antioxidant assays indicated superior activity for the methanol extract compared to the EO. Furthermore, antimicrobial testing revealed that the EO demonstrated broader and more effective antimicrobial action, exhibiting lower MIC and MBC values against several bacterial and fungal strains. Collectively, these results highlight F. platycarpa as a valuable source of bioactive compounds with promising applications in antidiabetic, neuroprotective, antioxidant, and antimicrobial therapies.
- MakaleAçık Erişim2026Scopus SJRQ1Psychological Needs and Problematic Social Media Use in Adolescents: A Gender-Moderated Mediation via Sensation Seeking and Cognitive Flexibility
Dombak, Kübra; Yayla, İbrahim Erdoğan; Makas, Samet; Çelik, Eyüp; Sahranç, Ümit; Kaya, Mehmet
Background: The purpose of this study is to examine the mediating roles of cognitive flexibility and sensation seeking in the relationship between basic psychological needs and problematic social media use. Furthermore, the moderating effect of gender on indirect effects has been examined. Method: The sample of the study consisted of 838 Turkish adolescents aged between 14 and 18 (46.2% female; Mean = 15.6, SD = 1.71). Participants completed the Bergen Social Media Addiction Scale, the Basic Psychological Needs Scale, the Cognitive Flexibility Scale, and the Brief Sensation Seeking Scale. Data were analyzed using structural equation modeling (SEM) with the AMOS 26.0 program. Results: A significant relationship was found between basic psychological needs and problematic social media use (r = 0.43, p < 0.001). Both cognitive flexibility and sensation seeking partially mediated this relationship in girls (β = −0.23, p < 0.001), while fully mediating it in boys (β = 0.03, p = 0.675). Conclusions: The findings suggest that problematic social media use in adolescents may be associated with cognitive flexibility and increased sensation-seeking tendencies stemming from unmet psychological needs, and that gender plays an important role in this relationship.
AtıfScopus4WoS3OpenAlex3İncele - MakaleAçık Erişim2026Scopus SJRQ1Corn Oil Oleogel With γ-Oryzanol/β-Sitosterol: Structural, Thermal, Textural, and Oxidative Characterization
Elbir Abca, Tuğba; Gençcelep, Hüseyin
In this study, a corn oil oleogel was prepared using γ-oryzanol and β-sitosterol to create a “healthier solid fat-like” structure aimed at reducing saturated and trans fat consumption. To prepare six different oleogels, a γ-oryzanol:β-sitosterol mixture (60:40) was added to corn oil at concentrations ranging from 6% to 15%. The samples were comprehensively evaluated in terms of oil-binding capacity and color; thermal behavior (including melting/crystallization properties); crystal structure; texture properties (hardness, stickiness, cohesion, and spreadability); molecular interactions and oxidative stability. The findings showed that all formulations had high oil binding capacity and that increasing the oleogelator concentration had a limited effect on oil binding. It has been determined that concentration plays an important role in the product's thermal resistance. Results show that as the oleogelator ratio increases, the structure becomes stronger and more durable; the melting behavior in thermal measurements shifts to higher temperatures. Crystal structure analyses support the formation of an oleogel network, while FTIR results indicate that the structure is formed predominantly through physical interactions. Consequently, it has been demonstrated that corn oil can acquire solid fat-like functional properties through this approach and offers a viable option for developing healthier fat formulations, particularly in spreadable products, margarine, and bakery fats.
- MakaleAçık Erişim2026Scopus SJRQ1Upper extremity muscle thickness and grip strength following a boccia-based intervention in hemiparetic individuals
Hazar, Emre Berk; Güder, Betul Canbolat; Hazar, Kursat; Gök, Umut Diyar; Alkhamees, Nouf H.; Ibrahim, Zizi M.; Al-Mhanna, Sameer Badri; Batrakoulis, Alexios
Introduction The global prevalence of stroke is increasing, highlighting the critical importance of effective post-stroke rehabilitation. Although boccia was originally designed for individuals with special needs, its potential benefits for stroke rehabilitation, particularly regarding task-related changes in ultrasound-observed muscle characteristics, have not been thoroughly investigated. Purpose This study aimed to examine the association of an 8-week boccia-based intervention with changes in upper extremity muscle thickness and grip strength in individuals with hemiparesis following stroke. Methods A total of 22 stroke survivors were randomly allocated to a boccia group (Boc, n = 12) or a control group (Ctrl, n = 10). While the control group received conventional physical therapy for eight weeks, the boccia group participated in both physical therapy and boccia-based intervention three times per week. Upper extremity muscle thickness and grip strength were assessed before and after the intervention. Results In the control group, a significant increase was observed only in the triceps brachii muscle thickness. In contrast, the boccia group demonstrated statistically detectable increases in forearm muscles (flexor digitorum profundus, flexor digitorum superficialis, pronator teres, and brachioradialis), triceps brachii muscle thickness, and grip strength. Conclusion Incorporating boccia-based intervention into the rehabilitation programs of individuals with hemiparesis after stroke may be associated with broader upper extremity muscle involvement and concurrent improvements in grip strength. These findings should be interpreted as exploratory and hypothesis-generating.
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