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  • MakaleAçık Erişim2023
    Siber Stalklama Ölçeği’nin Türk Kültürüne Uyarlanması: Geçerlik ve Güvenirlik Çalışması

    Demir, Mustafa; Koçak, Lokman; Özgöl, Mustafa

    Bu araştırmada, Siber Stalklama Ölçeği’nin Türk kültüründeki geçerlik ve güvenirliğinin incelenmesi amaçlanmıştır. Çalışma grubu, yaş aralığı 19-47 arasında değişen 162 kadın ve 103 erkek olmak üzere toplamda 265 yetişkinden oluşmaktadır. Geçerlik işlemleri kapsamında açımlayıcı faktör analizi (AFA) ve doğrulayıcı faktör analizi (DFA) kullanılmıştır. AFA sonucunda modeli %37.65 oranında açıklayan tek faktörlü bir yapı elde edilmiştir. DFA sonucunda ise modelin veri ile uyumunun iyi düzeyde olduğu belirlenmiştir (X2/sd= 1.63, CFI= .95, GFI= .93, AGFI= .89, RMSEA= .06, SRMR= .05). Güvenirlik için Cronbach alfa iç tutarlık katsayıları AFA ve DFA örneklemleri için sırasıyla .81 ve .83, iki yarı test güvenirliği ise .77 ve .76 olarak hesaplanmıştır. Elde edilen bu bulgular, ölçeğin Türk kültüründe geçerli ve güvenilir bir ölçme aracı olduğunu göstermektedir.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfOpenAlex5TR Dizin1
    TR Dizinİncele
  • MakaleAçık Erişim2023
    Türkiye’deki Profesyonel ve Amatör Lig Futbolcularının Organik Gıda Tercihlerinin Belirlenmesi

    Kul, Murat; Gıdık, Betül; Gidik, Osman; Evli, Fatih; Evli, Meltem

    Bu çalışmanın amacı amatör ve profesyonel liglerde futbol oynayan sporcuların organik gıda tercihlerini, medeni durum, oynadığı lig, yaş, spor yaşı, eğitim durumu, kronik sakatlık durumu, oynadığı mevki, gelir düzeyi gibi değişkenler açısından incelenmiştir. Çalışma, amatör liglerde oynayan 838, profesyonel liglerde oynayan 233, toplamda 1071 futbol oyuncusu üzerinde gerçekleştirilmiştir. Çalışmada veri toplama aracı olarak Kişisel Bilgi Formu, “Organik ürün tüketimini etkileyen faktörler ve tutumlar üzerine bir saha çalışması” (Sarıkaya, 2007), “Erciyes Üniversitesi İİBF akademik ve idari personeli ile İİBF işletme gündüz ve ikinci öğretim öğrencilerinin organik ürünleri algılamaları” (Kacur, 2009) ölçekleri kullanılmıştır. Verilerin analizinde iki bağımsız değişken arasındaki anlamlı farkın olup olmadığını belirlemek amacı ile t-Test kullanılmıştır. Birden fazla bağımsız değişkenin kendi aralarındaki ilişkiyi belirlemek amacı ile Anova, hangi grupların arasında anlamlı fark olduğu ise Tukey Post Hoc testi uygulanmıştır. Sonuçta katılımcılarım medeni durum, kronik hastalık durumu, yaş, eğitim durumu, oynadığı lig ve gelir durumu değişkenlerinde anlamlı fark tespit edilmiştir. Bununla birlikte katılımcıların organik gıdalar hakkında bilgi sahibi oldukları ve organik gıdaları sağlıklı buldukları sonucuna da ulaşılmıştır.

    • SDG 2 · Açlığa Son
    • SDG 3 · Sağlık ve Kaliteli Yaşam
    TR Dizinİncele
  • MakaleAçık Erişim2023
    Evaluation of Noise Levels in Flour Factories in Terms of Occupational Health and Safety

    Albayrak, Sirer; Melike, Yağcı; Ozdemir, Mustafa

    This study aims to determine the daily noise exposure levels in flour mills and evaluate the effects on the health and safety of workers. The study measured the equivalent sound pressure levels of workers exposed in two flour mills operating in Konya province in dBA. The factories include machines with high noise levels, such as sifters, sieves, and rollers. A Type-2 class sound pressure level meter was used in the measurements taken in accordance with ISO 9612: 2009 standard. Based on the measured values, the A-weighted equivalent sound pressure levels were determined, and the daily personal noise exposure levels were calculated taking into account the working hours. It was determined that the equivalent sound pressure levels and the daily individual noise exposure levels of the workers were in the range of 88.2-97.7 dBA and 87.9-97.4 dBA, respectively, and above the minimum daily personal exposure limit (80 dBA) specified in the legislation. As a result of the study, it was evaluated that the noise in flour mills can negatively affect the health and safety of workers as well as their job performance.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 8 · İnsana Yakışır İş ve Ekonomik Büyüme
    AtıfOpenAlex3TR Dizin3
    TR Dizinİncele
  • MakaleAçık Erişim2023
    Covid-19 Pandemisinde Trabzon İli Tıbbi Atık Verilerinin Değerlendirilmesi

    Fandaklı, Seda; Ates, Fatih; Atar, Büşra

    Nüfusun, şehirleşmenin ve toplumsal refah düzeyinin artışı, teknolojinin gelişmesi, satın alma gücünün artışı, tüketim alışkanlıklarının değişimi, hizmetlerde lüks ve kalite arayışı atık miktarını artırmaktadır. Bu çalışmada, ayrı atık toplama ve azaltma stratejileri ile Trabzon İl Ambulans Servisi ve Toplum Sağlığı Merkezleri'nin atık yönetimini ve bu kurumlardaki atık miktarı ve dağılımına Covid-19'un etkisini incelenmiştir. Covid-19 enfeksiyonunun atık miktarına ve dağılımına etkisini incelemek için ülkemizde Covid-19 enfeksiyonunun ilk görüldüğü 2020 yılı ile önceki ve sonraki yılların verileri karşılaştırılmıştır. Trabzon İli Ambulans Servisinde, ülkemizde ilk Covid-19 vakasının görüldüğü yıl olan 2020 yılında öncesi ve sonrası yıllara göre daha fazla tıbbi atık miktarı (8641 kg) ortaya çıktığı tespit edilmiştir. Toplum Sağlığı Merkezinde ise 2020 yılında oldukça fazla artış gösteren tıbbi atık miktarı, en fazla 2021 yılında (5350 kg) olarak gerçekleşmiştir. Tıbbi atık yönetimi çeşitli riskleri de bünyesinde barındıran maliyetli bir süreçtir. Mevzuata uyumlu atık yönetimi ile riskler engellenebilir ve karşılaşılabilecek iş kazaları da minimize edilebilir. Atık yönetiminin bütün evrelerinde dikkat edilmesi gereken nokta; insan sağlığını, çevre sağlığını ve ekonomiyi olumsuz etkilemeyecek adımların atılmasıdır.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 11 · Sürdürülebilir Şehirler ve Topluluklar
    • SDG 12 · Sorumlu Üretim ve Tüketim
    TR Dizinİncele
  • MakaleAçık Erişim2023
    Üniversite Öğrencilerinde Günlük Alınan Besin Öğeleri Dağılımının ve Metabolik Sendrom Riskinin Belirlenmesi: Bayburt Üniversitesi Örneği

    Akeren, Zahide; Kaya, Oncagül

    Amaç: Bu çalışma, Bayburt Üniversitesi Sağlık Bilimleri Fakültesi’nde öğrenim gören öğrencilerin günlük alınan ana besin öğeleri dağılımının ve metabolik sendrom riskinin belirlenmesi amacıyla gerçekleştirildi. Gereç ve Yöntemler: Araştırma verileri Aralık 2022-Şubat 2023 tarihleri arasında yüz yüze toplandı. Çalışmaya katılmayı kabul eden öğrencilere “veri toplama formu” ve “Metabolik Sendrom Araştırma Formu” doldurtulduktan sonra 24 saatlik besin tüketim kaydı verildi. Geriye dönük olarak tüketilen besinlerini kaydetmeleri istendi ve bu işlemler toplamda 15-20 dakika arasında bitirildi. Beslenme kayıt formları ile elde edilen veriler, “Beslenme Bilgi Sistemi (BeBİS 9.0) programı” kullanılarak değerlendirildi. Bulgular: Üniversite öğrencilerinin metabolik sendrom risk ortalamasının 6,26±2,03 olduğu, %82,9’unun orta ve yüksek risk grubunda olduğu belirlenmiştir. Öğrencilerin tanıtıcı bilgileriyle metabolik sendrom riski karşılaştırıldığında; 26-30 yıl (9.57±2.99), grubunda olan öğrencilerin metabolik sendrom riskinin 15-20 yıl (6.10±2.20) ile 21-25 yıl (6.20±1.73) gruplarında yer alan öğrencilerden anlamlı olarak yüksek bulundu (p<0,001). Öğrencilerin metabolik sendrom risk düzeyleri ile cinsiyet, bölüm, sınıf, sigara, alkol, fiziksel aktivite ve kronik hastalık varlığı değişenleri arasında anlamlı farklılık bulunmadı (p>0,05). Öğrencilerin metabolik sendrom risk düzeyleri enerji ve ana besin öğeleri alımlarına göre karşılaştırıldığında; alınan toplam enerji (p<0,001), tüketilen su (p=0,010), toplam yağ (p<0,001), karbonhidrat (p<0,001), lif (p=0,020) ve çoklu doymamış yağ (p<0,001) ile aralarındaki istatistiksel anlamlı fark olduğu bulunurken, protein ve alkol (meyve, sebze, fermante ürünler) tüketimine göre anlamlı fark bulunmadı (p>0,05). Sonuç: Bu çalışmada üniversite öğrencilerinin önemli bir kısmının (%82,9) metabolik sendrom riski taşıdığı, özellikle enerji alımı ko- nusunda dikkatli olunması gerektiği sonucuna ulaşıldı.

    • SDG 2 · Açlığa Son
    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfOpenAlex3TR Dizin5
    TR Dizinİncele
  • MakaleAçık Erişim2023
    Investigation of the relationship between NFKB1 polymorphisms and telomere length and apoptosis in patients with type-2 diabetes

    Dirican, Ebubekir; Kaya, Yasemin

    Purpose: Type 2 diabetes mellitus (T2DM) is a heterogeneous, chronic, and metabolic disease that affects a significant proportion of the global population. This study aimed to evaluate the effect of NFKB1-94 ATTG ins/del polymorphisms on the expression of apoptosis genes and telomere length (TL) in patients with T2DM compared with healthy individuals.Materials and Methods: Sixty-nine T2DM patients and sixty healthy people were enrolled in the study. DNA and RNA were isolated from the blood samples. NFKB1 genotypes were identified by Sanger sequencing. For TL analyses and to investigate the expression of the caspase-3, caspase-9, bax, and bcl2 genes, RT-PCR was utilized.Results: There was a significant difference between the NFKB1-94 ins/del genotype patients and the control group (OR:0.4792 (0.2345-1.011)). However, the distribution of other genotype/alleles (ins/ins and del/del) showed no difference between T2DM and control groups. The allelic frequency of NFKB1-94 ins/del was 0.455/0.235 for the T2DM group and 0.435/0.165 for the control group. An increase in the mRNA expression of caspase-3, caspase-9 and Bax genes was observed in the T2DM group compared with the healthy group, while a decrease in the Bcl2 gene was found in the T2DM group. TL in T2DM patients was shorter than in healthy individuals.Conclusion: NFKB1-94 ins/del polymorphisms show significant differences in T2DM patients. We observed that apoptosis was activated and TL was shortened in patients with T2DM. However, no relationship between NFKB1 polymorphisms and apoptosis and TL could not be determined.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    Web of ScienceTR Dizinİncele
  • MakaleAçık Erişim2023
    LRIG1 levels in chronic rhinosinusitis with nasal polyps

    Uzunçakmak, Sevgi Karabulut; Sahin, Abdulkadir; Özçelik, Aysegul Tavaci; Halici, Zekai

    Purpose: Nasal polyps (NPs), usually occurring together with chronic rhinosinusitis (CRS), are benign masses of mucosal origin arising from inflammation. The transmembrane protein known as leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) is a member of the Lrig family. Lrig1 is frequently expressed in the respiratory tract and epithelial tissues and can inhibit several signaling pathways involved in cell proliferation. The aim of this study was to determine Lrig1 levels in NP tissues of patients with CRS. Material and Methods: This study included 36 patients with CRS and NPs and 15 patients who underwent rhinoplasty as the control group. The Lrig1 levels of all participants were measured by the ELISA method.Results: This study revealed that Lrig1 levels were significantly lower in NP tissues than in tissues of the control group. The mean level of Lrig1 of the NP tissues was 22.2 ng/ml, while the mean level of the control group was 28.5 ng/ml. According to the results of ROC analysis, Lrig1 levels have the power to distinguish polyp tissues from control tissues (AUC=0.794). Lrig1 levels were higher in tissues with scores of 4-8 than in tissues with scores of 16-20 based on the results of computed tomography scoring. According to endoscopic evaluations, Lrig1 levels of tissues with scores of 5-8 or 9-11 were relatively lower than those of tissues with scores of 2-4.Conclusion: Lrig1 levels were found to be decreased in NP tissues. Thus, Lrig1 may be used to confirm the presence of NPs. Lrig1 may also be helpful in NP grading. Increasing the Lrig1 levels in cases of NPs has the potential to become a targetable treatment modality.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS1OpenAlex1TR Dizin1
    Web of ScienceTR Dizinİncele
  • MakaleAçık Erişim2023Scopus SJRQ1
    The Phenolic Profile and Anti-Inflammatory Effect of Ethanolic Extract of Polish Propolis on Activated Human Gingival Fibroblasts-1 Cell Line

    Kurek-Górecka, Anna; Klósek, Malgorzata; Pietsz, Grazyna; Czuba, Zenon P.; Kolayli, Sevgi; Can, Zehra; Balwierz, Radoslaw; Olczyk, Pawel

    Propolis, owing to its antibacterial and anti-inflammatory properties, acts as a cariostatic agent, capable of preventing the accumulation of dental plaque and inhibiting inflammation. The anti-inflammatory properties of propolis are attributed to caffeic acid phenethyl ester (CAPE), which is present in European propolis. The objective of the conducted study was to assess the anti-inflammatory effects of the Polish ethanolic extract of propolis (EEP) and isolated CAPE on stimulated with LPS and IFN-alpha, as well as the combination of LPS and IFN-alpha. The cytotoxicity of the tested compounds was determined using the MTT assay. The concentrations of specific cytokines released by the HGF-1 cell line following treatment with EEP (25-50 mu g/mL) or CAPE (25-50 mu g/mL) were assessed in the culture supernatant. In the tested concentrations, both CAPE and EEP did not exert cytotoxic effects. Our results demonstrate that CAPE reduces TNF-alpha and IL-6 in contrast to EEP. Propolis seems effective in stimulating HGF-1 to release IL-6 and IL-8. A statistically significant difference was observed for IL-8 in HGF-1 stimulated by LPS+IFN-alpha and treated EEP at a concentration of 50 mu g/mL (p = 0.021201). Moreover, we observed that CAPE demonstrates a stronger interaction with IL-8 compared to EEP, especially when CAPE was administered at a concentration of 50 mu g/mL after LPS + IFN-alpha stimulation (p = 0.0005). Analysis of the phenolic profile performed by high-performance liquid chromatography allowed identification and quantification in the EEP sample of six phenolic acids, five flavonoids, and one aromatic ester-CAPE. Propolis and its compound-CAPE-exhibit immunomodulatory properties that influence the inflammatory process. Further studies may contribute to explaining the immunomodulatory action of EEP and CAPE and bring comprehensive conclusions.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS17OpenAlex19
    Web of SciencePubMedİncele
  • MakaleAçık Erişim2023
    Effect of Reboxetine Treatment on BDNF, Synaptophysin, and PSD-95 Levels in the Spinal Dorsal Horn of Rats with Diabetic Neuropathy

    Yücel, Nazli Turan; Üçel, Umut Irfan; Özkay, Umide Demir; Ulupinar, Emel; Can, Ozgur Devrim

    Objective: It is known that neuropathic pain is accompanied by alterations in the levels of neurotrophic factors and synaptic proteins in the microenvironment of the spinal dorsal horn. Such changes contribute to hyperalgesia and allodynia processes; thus, analgesic drugs can exert their pharmacological effects by affecting the expressions, levels, or functions of these endogenous substances. In this study, based on the knowledge that reboxetine (a selective noradrenaline reuptake inhibitor) has the potential for antihyperalgesic efficacy in diabetic neuropathy, we aimed to examine the probable effects of this drug on diabetes-induced changes in brain-derived neurotrophic factor (BDNF), synaptophysin (the pre-synaptic marker of synaptic integration), and postsynaptic density-95 (PSD-95) (the postsynaptic marker of synaptic integration) levels in the superficial laminae of the dorsal horn.Methods: Experimental diabetes was induced by a single-dose injection of streptozotocin (STZ) (50 mg/kg) in rats. After four week-long induction period of painful diabetic neuropathy, rats were treated orally with 8 mg/kg reboxetine for two weeks. Hyperalgesia responses were evaluated by using the Randall-Selitto and Hargreave's tests. Following the pain tests, immunohistochemical studies were performed.Results: Two weeks of reboxetine administration increased the reduced paw withdrawal thresholds and shortened the paw withdrawal latencies of diabetic rats in neuropathic pain tests, indicating the antihyperalgesic efficacy of this drug. Moreover, augmented BDNF and synaptophysin levels in diabetic rats reversed by reboxetine treatment. However, there was no alteration in the densities of PSD-95, in both STZ-diabetic and reboxetine-treated STZ-diabetic rats.Conclusion: The obtained results suggested that inhibition of central sensitization and modulation of spinal plasticity seem to be pharmacological mechanisms underlying reboxetine's antihyperalgesic effects on diabetic rats. However, further studies are still needed to clarify the exact mechanism of action.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS1OpenAlex1
    Web of ScienceTR Dizinİncele
  • MakaleAçık Erişim2023
    Beneficial Effect of Atomoxetine Treatment on Scopolamine-Induced Cognitive Impairments and Molecular Changes in Rats

    Yucel, Nazli Turan; Ucel, Umut Irfan; Kandemir, Ummuhan; Can, Ozgur Devrim

    Objective: Atomoxetine is a noradrenaline re-uptake inhibitory drug that is currently used in the pharmacological treatment of attention deficit/hyperactivity disorder in children, adolescents, and adults. Based on the findings that noradrenergic system is closely associated with learning and memory processes, dysfunction of this system might contribute to the pathophysiology of cognitive disorders. Therefore, atomoxetine, which alters the noradrenergic neurotransmission in the synaptic cleft, has a potential to modulate learning and memory functions in various areas of the central nervous system. In the present study, it was aimed to investigate the effects of atomoxetine treatment on the cognitive impairments in amnesic animals using behavioral and immunohistochemical methods.Methods: Male Sprague-Dawley rats (adult, weighing 250-300 g) were used in the experiments. Atomoxetine at doses of 3 or 6 mg/kg (i.p.) was administered to the rats for 14 days. Experimental amnesia was induced in the animals by applying scopolamine (0.5 mg/kg, i.p.) injection. Following the treatment protocol, Morris water maze and passive avoidance tests were conducted to assess spatial and emotional learning and memory parameters of rats, respectively. Piracetam (300 mg/kg daily for 14 days) was used as reference drug in these experiments. In addition, motor performances of the animals were evaluated by activity cage and Rota-rod tests. Subsequent to behavioral tests, rats were euthanized and immunohistochemical analyses were performed to determine the alterations in the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels in the hippocampi of the animals.Results: In the Morris water maze test, amnesic rats found the hidden platform slower and spent less time in the target quadrant compared to the healthy controls. On the other hand, atomoxetine treatments significantly decreased the escape latencies, and also increased the target quadrant time values of the amnesic animals at both doses. Data obtained from the passive avoidance test showed that second transition latency values of the amnesic rats were significantly shortened with respect to the control animals; while atomoxetine treatment prolonged these shortened values significantly. It was observed that atomoxetine did not alter motor coordination or spontaneous locomotor activities of animals. Moreover, this drug increased the BDNF and NGF levels in the hippocampal sub-regions which were diminished by scopolamine administration.Conclusion: The obtained findings showed that atomoxetine treatment significantly improved the impaired learning and memory performances of the rats induced by scopolamine administration. Furthermore, anti-amnesic effects of this drug were concomitant with increased neurotrophic factors levels in the hippocampal brain regions. These results suggest a notable therapeutic potential of this drug in the treatment of dementia and several cognitive disorders; however, it should be underlined they are needed to be confirmed by welldesigned clinical trials.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS3OpenAlex3
    Web of Scienceİncele
  • MakaleAçık Erişim2023
    Analysis of telomere length in patients with COVID-19 and investigation into its relationship with clinical- demographic data

    Savrun, Atakan; Dirican, Ebubekir

    Purpose: Novel coronavirus disease 2019 (COVID-19) is an infectious disease unknown before the 2019 outbreak in Wuhan. This study evaluated telomere length in COVID-19 (+) and (-) samples with clinical-demographic parameters.Materials and Methods: DNA was isolated from COVID-19 (+) (n=70) and (-) (n=70) patients. Telomere length was determined by real-time-PCR (RT-PCR). The 2- increment increment Ct method was used to analyze the telomere length of the samples.Results: There were significant differences in creatinine, LDH, ferritin, WBC, NEU and CRP in COVID-19 (+) patients compared to COVID-19 (-) patients. The NEU/LYM (or N/L) ratio was found higher in the patients with COVID-19 (+), than in COVID-19 (-). On the other hand, our COVID-19 (+) patients (mean +/- std:0.93 +/- 0.58) had significantly shorter telomere lengths than the COVID-19 (-) (mean +/- std:1.26 +/- 0.76). Moreover, COVID-19 (+) male patients (mean +/- std:1.06 +/- 0.50) had longer telomere length than female patients (mean +/- std:0.76 +/- 0.54). Telomere length was significantly shorter in patients with COVID-19 (+) with high blood urea nitrogen (BUN), high creatinine, high hematocrit, high NEU levels, normal platelets (PLT), and low WBC levels.Conclusion: Our findings suggest that telomere length and blood parameter levels influence the severity of COVID-19. Blood parameters differed in patients with COVID-19 (+) and COVID-19 (-). As a result, increasing the number of similar studies in the future can demonstrate the significance of our findings.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS2OpenAlex2
    Web of Scienceİncele
  • MakaleAçık Erişim2023Scopus SJRQ1
    Structure-function-guided design of synthetic peptides with anti-infective activity derived from wasp venom

    Boaro, Andreia; Ageitos, Lucia; Torres, Marcelo Der Torossian; Blasco, Esther Broset; Oztekin, Sebahat; de la Fuente-nunez, Cesar

    Antimicrobial peptides (AMPs) derived from natural toxins and venoms offer a promising alternative source of antibiotics. Here, through structure-function-guided design, we convert two natural AMPs derived from the venom of the solitary eumenine wasp Eu-menes micado into a-helical AMPs with reduced toxicity that kill Gram-negative bacteria in vitro and in a preclinical mouse model. To identify the sequence determinants conferring antimicrobial ac-tivity, an alanine scan screen and strategic single lysine substitutions are made to the amino acid sequence of these natural peptides. These efforts yield a total of 34 synthetic derivatives, including alanine substituted and lysine-substituted sequences with stabilized a-helical structures and increased net positive charge. The resulting lead synthetic peptides kill the Gram-negative pathogens Escheri-chia coli and Pseudomonas aeruginosa (PAO1 and PA14) by rapidly permeabilizing both their outer and cytoplasmic membranes, exhibit anti-infective efficacy in a mouse model by reducing bacte-rial loads by up to three orders of magnitude, and do not readily select for bacterial resistance.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfWoS34OpenAlex39
    Web of SciencePubMedİncele
  • MakaleAçık Erişim2023Scopus SJRQ1
    Catecholaminergic and Cholinergic Systems Mediate Beneficial Effect of Vortioxetine on Diabetes-Induced Neuropathic Pain

    Turan Yücel, Nazlı; Kandemir, Ümmühan; Üçel, Umut İrfan; Demir Özkay, Ümide; Can, Özgür Devrim

    The therapeutic potential of vortioxetine on mechanical hyperalgesia/allodynia was investigated in rats with streptozotocin-induced diabetes, and its possible mechanism of action was elucidated in this study. The obtained findings demonstrated that subacute vortioxetine treatment (5 and 10 mg/kg for 2 weeks) increased the reduced paw-withdrawal thresholds of diabetic rats both in the Randall–Selitto and Dynamic plantar tests. Moreover, the falling latencies of animals did not change in the Rota-rod assessments. These results suggest that vortioxetine administration significantly improved diabetes-induced hyperalgesia and allodynia responses in the rats without affecting their motor coordination. The vortioxetine (5 mg/kg)-induced antihyperalgesic and antiallodynic effects were reversed by AMPT, yohimbine, ICI 118,551, sulpiride and atropine pre-treatments, suggesting the involvement of the catecholaminergic system, α2- and β2-adrenoceptors, D2/3 dopaminergic receptors and cholinergic muscarinic receptors in the exhibited pharmacological activity, respectively. Moreover, the data from the immunohistochemical studies indicated that the inhibition of c-Fos overexpression in dorsal horn neurons also mediates the beneficial effect of this drug. Vortioxetine induced no difference in plasma glucose levels in diabetic rats. If clinical studies confirm these findings, the concomitant beneficial effect of vortioxetine on mood disorders and its neutral activity profile on glycemic control may make it an alternative drug for the treatment of neuropathic pain.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus6WoS4OpenAlex6
    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2023Scopus SJRQ2
    Socioeconomic status and wellbeing as predictors of students' academic achievement: Evidence from a developing country

    Erdem, Cahit; Kaya, Metin

    The COVID-19 pandemic has deepened the effects of socioeconomic status (SES) and wellbeing (WB) on students' academic achievement, particularly in developing countries; thus, it becomes necessary to understand the nature of these concurrent relationships. This study aimed to explore the relationships between SES, WB and academic achievement, based on the data from the Programme for International Student Assessment (PISA) in 2018 within the Turkish context. In this cross-sectional study, we used hierarchical multiple linear regression analysis to explore how the independent variables predicted academic achievement in blocks based on data from 6890 students attending 186 schools. The study revealed that the model, including the independent variables, predicted students' achievement in reading, mathematics and science; however, the prediction level of demographic factors and domains of WB were very low, while SES had the highest prediction level. The results offer insights into the predictors of academic achievement and educational inequalities in the context of a developing country.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 4 · Nitelikli Eğitim
    • SDG 10 · Eşitsizliklerin Azaltılması
    AtıfScopus35WoS28OpenAlex39
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2023Scopus SJRQ3
    A comparison of the associations between bone turnover markers and different sports fields: combat versus team sports

    Yıldız, K.; Uzunçakmak, S. Karabulut; Halıcı, Z.; Özçelik, C.; Yazıcı, A.G.

    Sedentary life brings risks that include osteoporosis, while physical activity has many benefits for health in general and the skeletal system. Irisin is a hormone-like myokine regulated by mechanical force and it contributes to cortical and trabecular bone mineral density. This study aimed to investigate the effects of different types of sports on bone health by measuring elite athletes’ fibronectin type III domain 5 (FNDC5), N-terminal collagen type I extension propeptide (PINP), and C-terminal cross-linking telopeptide of type I collagen (CTXI) levels. Combat sports athletes, team sports athletes, and sedentary control subjects were enrolled. Serum levels of proteins were measured by ELISA. FNDC5 levels of elite athletes were higher compared to the sedentary controls (P=0.0014). The highest FNDC5 level was measured in wrestlers among all considered groups. The PINP levels of the athletes were also higher than those of the sedentary control group (P=0.1431). The highest PINP level was determined in boxers. The CTXI levels of the athletes were lower than those of the sedentary control (P<0.0001). The lowest CTXI level was seen in boxers. The FNDC5 and PINP levels of combat sports athletes were higher than those of team sports athletes (P=0.0134 and P=0.0262, respectively), while the CTXI levels of combat sports athletes were lower than those of team sports athletes (P<0.0001). Our results indicated that FNDC5, PINP, and CTXI levels are associated with physical activity. The effect of the exercises performed by athletes of specific sports on bone health has not been studied in much detail before. Combining different exercises for athletes of a particular sport may be more beneficial for bone health.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2023Scopus SJRQ3
    Effects of electromagnetic radiation on neurogenesis and gene expression in amniocytes

    Uzun, Coşar; Erdal, Nurten; İzci Ay, Özlem; Karakaş, Ümit; Derici Yildırım, Didem; Durukan, Hüseyin; Akdag, Mahmut Berat; Erdal, Mehmet Emin

    The aim of the study was to investigate the genetic effects of commonly used radiofrequency on the amniocytes of pregnant women by examining the changes in the expression of genes related to signal transduction and neurogenesis induced by electromagnetic fields of radiofrequencies of 1800 and 2100 MHz by real-time PCR. Upon exposure of the amniocytes to electromagnetic radiation of 2100 MHz at high field strength, the expression levels of genes with important functions in the Wnt signaling pathways as well as neurogenesis-related genes were increased. The findings suggest that radiofrequency at high field strengths can have genotoxic effects during pregnancy.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus1WoS1OpenAlex1
    ScopusWeb of Scienceİncele
  • Kitap BölümüAçık Erişim2023
    Isothiocyanates as drug candidates in cancer prevention and treatment

    Saylan, Demet; Cebeci, Fatma

    Cancer is the second most common cause of death worldwide. Many methods such as surgery, chemotherapy, radiation therapy, etc. are being used for treatment. Most patients have a combination treatment with chemotherapy along with surgery or radiotherapy or both. Chemotherapy kills cancer cells by preventing them from reproducing, growing, and spreading in the body. Recently, safer alternatives to chemotherapy have been discovered and developed, as most of the drugs used in cancer treatment have side effects and a serious impact on patient comfort. As an alternative, the phytochemicals found in daily consumed plants are attractive candidates for clinical/pre-clinical evaluation because of their higher safety. In this context, certain degradation products of glucosinolates (isothiocyanates) are promising agents for cancer prevention and treatment.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    Scopusİncele
  • MakaleAçık Erişim2023Scopus SJRQ2
    Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products

    Putri, Oceu Dwi; Petchsuk, Atitsa; Buchatip, Suthawan; Supmak, Wilairat; Kaewsaneha, Chariya; Thananukul, Kamonchanok; Nim, Bunthoeun; Bayram, Sinan; Thumanu, Kanjana; Opaprakasit, Pakorn

    The role of eumelanin as a natural pigment in protecting human skin from ultraviolet (UV) light has drawn vast interest in the research and industrial community. Encapsulation of the compound by various shell materials has been extensively studied to optimize and prolong its shielding efficiency from UV penetration through the skin. Polylactide (PLA)-based copolymers have been widely used in the encapsulation of various active compounds due to their biocompatibility and biodegradability that facilitate sustained release of the active compounds. In this work, stereocomplex PLA (sc-PLA) derived from mixtures of poly(D-lactide-caprolactone-D-lactide), P(DLA-b-CL-b-DLA), a triblock copolymer with linear poly(L-lactide), and PLLA are employed to encapsulate eumelanin by an oil-in-water emulsion (O/W) technique. The effect of eumelanin distribution in PLA's enantiomers and ultrasonication on the physicochemical properties, encapsulation efficiency, and release behavior of the nano/microparticles were evaluated. The potential application of the resulting particles for sunscreen products was assessed in terms of UV absorbance and in vitro sun protection factor (SPF). The nano/microparticles show a hollow spherical structure, whose size can be controlled by ultrasonication. The distribution of eumelanin and the ultrasonication process play a key role in the growth of sc-PLA and the crystalline structure of the particles. The highest encapsulation efficiency of 46.6% was achieved for sc-PLA2U particles. The high content of eumelanin and the hollow structure with a large surface area lead to improvement in the UV absorbance and sunscreen performance of the particles, as revealed by the increase in the SPF value from 9.7 to 16.5. The materials show high potential for various applications, especially in cosmetic and pharmaceutical fields, as UV-shielding products.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus3WoS3OpenAlex3
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2023Scopus SJRQ2
    Determination of toxicity and radioprotective properties of bacterial and fungal eumelanin pigments

    Bayram, Sinan; Aygün, Bünyamin; Karadayi, Mehmet; Alaylar, Burak; Güllüce, Medine; Karabulut, Abdulhalik

    Purpose: Determination of the protective property of melanin, an organic polymer class consisting of phenolic and/or indolic compounds isolated from bacteria and fungi, against fast neutron radiation. To show that these melanin samples, which also have antioxidant and metal chelating properties, can be used as an active ingredient for a drug to be developed against neutrons used in nuclear research and medicine. Materials and methods: Bacterial and fungal media were prepared, and melanin pigments were produced and isolated. For molecular characterization of pigments, bacterial genomic DNA extraction, 16S rDNA gene amplification processes, and fungal genomic DNA extraction, ITS1, and ITS4 Gene Regions amplification were performed. The DEL assay was implemented to determine the genotoxicity properties of bacterial and fungal melanin pigments. Samples were prepared in a pad measuring 10 ml volume (60 × 15 mm) at a concentration of 0.2–1 microgram in 1% agarose gel for radiation-absorbed dose measurements. Absorption measurements were made using 241Am-Be fast neutron source and Canberra brand NP series BF3 gaseous detector to determine the neutron radiation absorption capacity of all samples. The results obtained to determine the absorption degrees of melanin samples were compared with paraffin and normal concrete, which are widely used in neutron radiation shielding studies. Results: Melanin pigments were obtained using different bacteria and fungi strains. Afterwards, the fast neutron radiation absorption capacity of these purified pigments were determined. Compared to reference samples, these pigments were found to have slightly lower radiation absorbing ability. In addition to these experiments, cytotoxicity tests were carried out using the Yeast DEL assay technique to evaluate the potential for use of these organic pigments in fields such as medicine and pharmacology. According to the results obtained from the tests, it was determined that these melanin samples did not have any toxic effects. Conclusion: It was determined that these melanin samples have the potential to be used as a radioprotective drug active substance to protect the tissues and cells of people exposed to neutron radiation after a nuclear accident or nuclear war. Giving a drug that will be developed by using these active ingredients before or after people are exposed to a radiation environment can provide great benefits.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus12WoS12OpenAlex17
    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2023Scopus SJRQ2
    Development of the diabulimia knowledge level scale

    Çetinkaya Özdemir, Serap; Semerci, Vahide; Sönmez Sarı, Ebru

    The aim of this study was to develop the Diabulimia Knowledge Level Scale. The nurses voluntarily participated in the research (n = 384). The Diabulimia Knowledge Level Scale consists of 19 items and four factors. The four factors that make up the scale according to the results of Exploratory Factor Analysis explain 68.53 % of the total variance. The total Cronbach alpha coefficient of the scale was found to be 0.92. The Diabulimia Knowledge Level Scale is the first scale developed to determine the level of diabulimia knowledge among nurses. The scale is valid and reliable.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus2WoS2OpenAlex3
    ScopusWeb of SciencePubMedİncele