Yazarlar
- Bayraktar, Bülent(33)
- Dertli, Enes(33)
- Dirican, Ebubekir(20)
- Akeren, Zahide(18)
- İspirli, Hümeyra(18)
- Kizil, Hamit Emre(17)
- Semerci, Vahide(14)
- Bayram, Sinan(13)
- Kul, Murat(13)
- Sönmez Sarı, Ebru(13)
- Agar, Guleray(12)
- Akman, Onur(12)
- Kırbaş, Zila Özlem(12)
- Akeren, İhsan(11)
- Koçak, Lokman(11)
- Makas, Samet(11)
- Can, Zehra(10)
- Uzunçakmak, Sevgi Karabulut(10)
- Yayla, İbrahim Erdoğan(10)
- Çelik, Eyüp(10)
- Bayraktar, B.(9)
- Bulbuloglu, Semra(9)
- Kızıl, Hamit Emre(9)
- Tekce, Emre(9)
- Aydemir, Uğur(8)
- Daştan, Buket(8)
- Hintistan, Sevilay(8)
- Kalyoncuo, Servet(8)
- Sönmez Sari, Ebru(8)
- Türkmen, Mutlu(8)
- Apaydın, Emine(7)
- Arslaner, Ayla(7)
- Beydemir, Şükrü(7)
- Dombak, Kübra(7)
- Kara, Yakup(7)
- Mercan, Emin(7)
- Semerci Çakmak, Vahide(7)
- Can, Özgür Devrim(6)
- Esgin, Özge(6)
- Güneş, Hüseyin(6)
Yayınlar
- MakaleYalnız künye2023Scopus SJRQ2The willingness of elderly care program students to care for older adults and the associated factors: a multi-centered research
Okur, Elif; Akbal, Yağmur; Yagci Sentürk, Aysun; Daştan, Buket; Kuralay, Çiğdem
Prospective technicians for elderly care are indispensable elements that should be included in the relevant system to meet the ever-increasing care needs of the aging world population and increase the quality of care. This research was conducted to evaluate the attitudes of students in the elderly care program at the associate degree toward the older adults and their willingness to provide care. The sample of this descriptive and cross-sectional study comprised 525 volunteer students in elderly care programs in five vocational schools of higher education located in northeastern Turkey between June 2020 and September 2020. Mean, standard deviation, number, percentage, independent t-test, and correlation analysis were used to evaluate the data. The study showed that the mean age of the students involved in the study was 20.3 ± 1.6. 77.7% of them were female, and 61.9% were in the first grade. Students’ willingness to care for older adults was found to be at a moderate level (36.3 ± 6.0). The students had a negative attitude (137.4 ± 26.7) about aging and elderliness. The willingness of male students to care for older adults was significantly higher (p <.05). Those who did not live with an older adult in the same house before had a more negative attitude toward them (p <.05). To get rid of personal and social stereotypes and have a positive attitude toward older adults, students should be provided to work in clinical environments that will allow them to spend more time with them.
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İncele - MakaleAçık Erişim2023Scopus SJRQ2Contribution of Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress and Autophagy Pathways to the Ameliorative Effects of Hesperidin in NaF-Induced Testicular Toxicity
Emre Kızıl, Hamit; Gür, Cihan; Ayna, Adnan; Darendelioğlu, Ekrem; Küçükler, Sefa; Sağ, Sevda
The ameliorative effects of hesperidin (HES) on the toxicities created by sodium fluoride (NaF) in the testes tissue of rats were studied via oxidative stress, apoptosis and endoplasmic reticulum (ER) stress pathways. The animals were divided into five distinct groups (7 rats in each group). Group 1 was control group, group 2 received NaF-only (600 ppm), group 3 received HES-only (200 mg/kg bw); group 4 received NaF (600 ppm)+HES (100 mg/kg bw) and group 5 received NaF (600 ppm)+HES (200 mg/kg bw) for 14 days. NaF-induced testes tissue damage by reducing activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and levels of glutathione (GSH), and increasing lipid peroxidation levels. NaF treatment significantly downregulated the mRNA levels of SOD1, CAT and GPx. NaF supplementation caused apoptosis in the testes by upregulating p53, NFkB, caspase-3, caspase-6, caspase-9, and Bax and downregulating Bcl-2. Furthermore, NaF caused ER stress via increasing mRNA transcript levels of PERK, IRE1, ATF-6 and GRP78. NaF treatment led to autophagy via upregulation of Beclin1, LC3A, LC3B and AKT2. In testes tissue, however, co-treatment with HES at doses of 100 and 200 mg/kg significantly reduced oxidative stress, apoptosis, autophagy and ER stress. Overall, the findings of this study suggest that HES may help to reduce testes damage caused by NaF toxicity.
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İncele - MakaleAçık Erişim2023Scopus SJRQ1Prevalence and predictors of psychological assistance services for older individuals in Turkish society
Coşkun, Hüseyin; Yildiz, Ibrahim; Alkan, Ömer
Background/aim: Due to the high contribution of psychological problems to the decline in the comfortable lifestyle of the older individuals, determining the factors that affect individuals' receiving psychological services and searching for solutions based on these factors is one of the primary concerns of national and international decision-makers. This study aimed to identify the factors that affect older individuals' access to psychological assistance services in Turkey. Methods: In this study, the Turkish Health Research micro dataset, which was conducted by the Turkish Statistical Institute (TURKSTAT) in 2016 and 2019, was employed. In this dataset, the data of 7,252 older individuals were analyzed. Using binary logistic analysis, the factors that are effective for obtaining psychological assistance for the older individuals were identified. Results: According to the results of the analysis, factors such as gender, education, general health status, disease status, payment of health expenditures, and body mass index affected older individuals who received psychological assistance. Conclusion: In recent years, there has been a rise in the availability of psychological assistance services for the older individuals. By identifying factors that increase the likelihood of receiving psychological assistance services, this study is expected to contribute to the creation and regulation of psychological assistance services to prevent possible psychological problems that may occur in old age, minimize the problems experienced by individuals, and promote a more comfortable lifestyle.
AtıfScopus23WoS23OpenAlex24İncele - MakaleYalnız künye2023Scopus SJRQ2The effect of guided imagery applied on geriatric orthopaedic patients on preoperative anxiety and comfort
Gunes, Huseyin; Saritas, Serdar; Ozdemir, Ahmet; Bulbul, Ali Savas
Background: This study was designed to examine the effect of guided imagery applied to geriatric orthopaedic patients on preoperative anxiety and comfort. Methods: This study was conducted as a randomized controlled trial. The population of the study consisted of geriatric patients treated in the orthopaedics and traumatology clinic of a university hospital. The sample consisted of 80 patients, including the experimental group (n = 40) and the control group (n = 40). Personal Descriptive Form, The State–Trait Anxiety Inventory (STAI) and General Comfort Scale were used as data collection tools. Results: After the guided imagery application, it was determined that the anxiety of the experimental group decreased statistically significantly, and their comfort improved (P < 0.05). Conclusion: After the imagery, it was determined that the patients in the experimental group had a decrease in their anxiety level and an improvement in their comfort. Since it is a low-cost and easily accessible method, applying imagery in the preoperative period is recommended.
AtıfScopus5WoS5OpenAlex5İncele - MakaleYayıncıda açık erişim2023Scopus SJRQ1Examining the attitudes of sexually abused and non-abused individuals towards marriage in terms of ambivalent sexism
Çelik, Eyüp; Dombak, Kübra; Kaya, Mehmet; Sahranç, Ümit; Makas, Samet; Koçak, Lokman; Takunyacı, Mithat; Bekir, Seyhan
The research aims to examine the attitudes of individuals who are victims of abuse and those who are not towards marriage in terms of ambivalent sexism. The research study group consists of 718 individuals between the ages of 18–48. Research data were collected with the Inonu Marriage Attitude Scale and Ambivalent Sexism Inventory. As a result of the correlation analysis, it was concluded that the marriage attitude was positively and significantly correlated with hostile and protective sexism. However, since the relationship between hostile sexism and attitudes towards marriage is lower than that of protective sexism, hostile sexism was not included in the model as a control variable. In the covariance analysis, it is seen that protective sexism and sexual abuse predict the attitude towards marriage at a statistically significant level. In addition, when the effect of sexual abuse on the attitude towards marriage was examined by controlling the protective sexism variable, it was found that it was statistically significant without the effect of sexism. According to the findings, it was determined that individuals who were not victims of sexual abuse had higher attitudes towards marriage than those who were victims. Copyright:
AtıfScopus4WoS5OpenAlex4İncele - MakaleYalnız künye2023Scopus SJRQ1Utilisation of an active branching sucrase from Lactobacillus kunkeei AP-37 to produce techno-functional poly-oligosaccharides
İspirli, Hümeyra; Korkmaz, Kader; Arioglu-Tuncil, Seda; Bozkurt, Fatih; Sağdıç, Osman; Tunçil, Yunus Emre; Narbad, Arjan; Dertli, Enes
Glucansucrase AP-37 was extracted from the culture supernatant of Lactobacillus kunkeei AP-37 and characteristics of the glucan produced by the active glucansucrase in terms of structural and functional roles were determined in this study. A molecular weight around 300 kDa was observed for glucansucrase AP-37 and its acceptor reactions with maltose, melibiose and mannose were also conducted to unveil the prebiotic potential of the poly-oligosaccharides formed via these reactions. The core structure of glucan AP-37 was determined by 1H and 13C NMR and GC/MS analysis which revealed that glucan AP-37 was a highly branched dextran composing of high levels of (1 → 3)-linked α-D-glucose units with low levels of (1 → 2)-linked α-D-glucose units. The structural features of the glucan formed, demonstrated that glucansucrase AP-37 was an α-(1 → 3) branching sucrase. Dextran AP-37 was further characterised by FTIR analysis and XRD analysis demonstrated its amorphous nature. A fibrous compact morphology was observed for dextran AP-37 with SEM analysis whereas TGA and DSC analysis revealed its high stability as no degradation was observed up to 312 °C. Finally, the prebiotic potential of the dextran AP-37 and the gluco-oligosaccharides produced with the acceptor reaction of α-(1 → 3) branching sucrase AP-37 were determined and promising results were found for the gluco-oligosaccharides to act as prebiotics.
AtıfScopus13WoS12OpenAlex13İncele - MakaleAçık Erişim2023Scopus SJRQ4The Effect of Different Physical Education Class Hours Applied in Secondary Education on Certain Physiological and Physical Parameters
Sever, Mehmet Onur; Söyler, Mehmet; Çingöz, Yunus Emre; Barkin, Emrah
This study investigates the effects of different physical education lesson hours applied to secondary school students on some physical and physiological parameters. A total of 36 secondary school students voluntarily participated in the study: respectively, 18 from Group 1 and 18 from Group 2 (age: 14.94±0.41 / 14±0.34 years; height: 175.22±7.62 / 169.33±6.95 cm; weight: 61.95±9.07 / 56.83±6.33 kg). While Group 1 students received 8 hours of physical education lessons per week, Group 2 students were given 2 hours of physical education lessons according to the Ministry of National Education curriculum. Body weight (kg) and body fat percentage (%) were determined using the Inbody 270 professional body analysis device. A portable dynamic balance device was used to determine the students' balance. The test results were analyzed using the SPSS Statistics software. Non-parametric tests were employed since the data did not show a normal distribution. The Mann-Whitney U test was used to test the significance of the difference in balance and body fat percentage (BFP) level averages between the two independent groups. Upon evaluating our data, it was statistically ascertained that the dynamic balance (Balance) values of Group 1 secondary school students were significantly higher when compared to Group 2 students. However, no statistically significant difference was found in body fat percentage (BFP) values between Group 1 and Group 2. As a result, it is seen that increasing physical education lesson hours in secondary education contributes to some physical development of young individuals.
- MakaleYalnız künye2023Scopus SJRQ1Investigation of the effect of group counselling based on schema therapy on academic expectation stress in high school students
Koçak, Lokman; Çelik, Eyüp
This research is a preliminary evaluation study to determine whether group counselling based on schema therapy has an effect on academic expectation stress in high school students. In this study, a 2 × 3 split-plot design was used. The Academic Expectation Stress Inventory was applied for data collection purposes. The effect of group counselling based on schema therapy on academic expectation stress was tested using a two-factor ANOVA for mixed measurements. As a result of the analysis, the intervention*time effect was found to be significant with regard to academic expectation stress. The findings obtained in the study reveal that group counselling based on schema therapy creates a significant decrease in adolescents' academic expectation stress level, and this decline continues, as shown in the follow-up test. As a result, it can be said that the group counselling programme based on schema therapy, which was developed as a preliminary evaluation study, has the potential to reduce the academic expectation stress level of high school students.
AtıfScopus3WoS2OpenAlex3İncele - MakaleYalnız künye2023Scopus SJRQ1Assessing Acute Responses to Exercises Performed Within and at the Upper Boundary of Severe Exercise Domain
Norouzi, Mahdi; Cabuk, Refik; Balci, Gorkem Aybars; As, Hakan; Ozkaya, Ozgur
Purpose: The highest work-rate that provides maximal oxygen uptake ((Formula presented.)) may be one of the best exercise stimuli to yield both (Formula presented.) and lactate accumulation. The aim of this study was to analyze physiological and metabolic acute responses of an exercise modality performed at the upper boundary of the severe exercise domain, and compare those responses with exercise modalities applied within the severe exercise domain. Method: Ten trained male cyclists participated in this study. The (Formula presented.), corresponding power output (POVO2max), and the highest work-rate that provides the (Formula presented.) (IHIGH) were determined by constant work-rate exercises. Cyclists performed three high-intensity interval training (HIIT) strategies as follows; HIIT-1: 4–6 × 3-min at 95% of POVO2max with 1:1 (workout/rest ratio); HIIT-2: 16–18 × 1-min at 105% of POVO2max with 1:1; HIIT-3: 4–7 × 1-2-min at the IHIGH with 1:2. Capillary blood samples were analyzed before, immediately after HIIT sessions, and at the first, third, and fifth minutes of recovery periods. Lactate difference between the highest lactate response and resting status was considered as the peak lactate response for each HIIT modality. Results: Time spent at (Formula presented.) was greater at HIIT-1 and HIIT-3 (272 ± 127 and 208 ± 111 seconds, respectively; p = 0.155; effect size = 0.43) when compared to the HIIT-2 (~26 seconds; p < 0.001), while there was a greater lactate accumulation at HIIT-3 (~16 mmol·L−1) when compared to HIIT-1 and HIIT-2 (12 and 14 mmol·L−1, respectively; p < 0.001). Conclusions: In conclusion, HIIT-3 performed at IHIGH was successful to provide time spent at (Formula presented.) with a greater lactate accumulation in a single session.
AtıfScopus8WoS8OpenAlex6İncele - MakaleAçık Erişim2023Evaluation of activity-based mathematics teaching to students with learning disabilities in out-of-school learning environments
Filiz, Tunahan; Güneş, Gönül
This study aimed to support primary school students with learning difficulties in out-of-school learning environments with artistic or sportive activities. The case study method, one of the qualitative research methods, was used in the study. The activities prepared for students with learning difficulties were shaped by considering four learning areas (numbers, geometry, measurement, and data processing). Each learning area was associated with music, visual arts, sports, and drama methods, respectively. The prepared activities were implemented for four days between 16-19 April 2023, when schools were on holiday. The activities were applied to students in 20 lessons in five lessons of 40 minutes each day. The project's target group consisted of 24 students officially diagnosed with learning disabilities and attending the third and fourth grades of primary school. This study collected data from interviews, observation, document review, and curriculum-based evaluation methods. The content analysis method was used for data analysis. The results of the study show that activity-based mathematics teaching has a positive effect on student learning. Artistic or sportive activities can be added to school programs for students with learning difficulties to learn in real-life environments.
AtıfScopus2OpenAlex1İncele - MakaleAçık Erişim2023Scopus SJRQ1Green Synthesis, Characterization, Antioxidant, Antibacterial and Enzyme Inhibition Effects of Chestnut (Castanea sativa) Honey-Mediated Silver Nanoparticles
Keskin, Merve; Kaya, Gülşen; Bayram, Sinan; Kurek-Górecka, Anna; Olczyk, Paweł
In this study, chestnut honey-based silver nanoparticles (CH-AgNPs) were synthesized at different temperatures (30, 60 and 90 °C) and these nanoparticles were characterized by different techniques such as UV–vis spectrophotometer, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX). The DPPH free radical scavenging assay was used to determine the antioxidant activity of the obtained nanoparticles. The inhibition effects of these nanoparticles for some clinically important enzymes such as myeloperoxidase and collagenase were investigated. In addition, the disk diffusion method (DDM), agar well diffusion (AWD), and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) techniques were used to determine the antibacterial activity of CH-AgNPs. In honey-based silver nanoparticle production processes using green synthesis, it was determined that the nanoparticle sizes decreased from 55 to 27 nm with an increase in temperature. In addition, it was determined that the rate of inhibition of myeloperoxidase (36.4% to 34.0%) and collagenase enzymes (74.2% to 68.7%) increased with a decrease in particle size. As a result of the antibacterial activity tests, it was observed that CH-AgNPs have antibacterial activity against all target pathogens including Gram-positive and Gram-negative bacteria. The obtained results show that CH-AgNPs produced using chestnut honey have the potential to be used in fields such as medicine, pharmacy and cosmetic technology.
AtıfScopus48WoS41OpenAlex42İncele - MakaleAçık Erişim2023Scopus SJRQ3COMPARATIVE ANALYSIS OF BIOCHEMICAL CONTENT, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF HYPERICUM PERFORATUM L. SPECIES IS GROWN IN TÜRKİYE
Gul, Volkan; Cetinkaya, Hatice; Dinler, Burcu Seckin; Sefaoglu, Firat
Many external factors, such as climatic conditions, geographical differences, and altitude, directly affect the primary and secondary metabolites and therapeutic use of St. John's Wort (Hypericum perforatum L.), an important plant in alternative medicine. This study was carried out to identify the antioxidant and antimicrobial activities and the content of proline, malondialdehyde, hydrogen peroxide, flavonoid, anthocyanin, and total phenolic in the St. John's Wort growing naturally in different regions of Bayburt. The St. John's Wort samples were collected from 11 different locations. As a result of the analyses carried out on the plant samples, it was found that the content of proline was within the range of 4.6-8.2 µmol g-1 DW, the amount of malondialdehyde was within the range of 0.69-1.10 nmol g-1 DW, the amount of hydrogen peroxide was within the range of 79.89-155.49 µmol g-1 DW, the amount of flavonoids was within the range of 91.38%-100.27%, the amount of anthocyanin was within the range of 0.15-1.11 mkmol g-1 DW, the total phenolic content was within the range of 15.82-45.22 mg GAE g-1, and the antioxidant activity was within the range of 6.07-105.60 µg mL-1. In conclusion, although the biochemical contents and nonenzymatic antioxidant activities showed a wide variety, the antioxidant activity was found to be higher in samples 5, 8, and 11. According to the antimicrobial activity results, some plant extracts were effective on bacteria and fungi, especially samples 5, 6, 8, and 11 showed an effect at the concentration of 200 μg mL-1. This study, the first regional study on this subject, will contribute to future research and clinical trials in the health field.
AtıfScopus4WoS2OpenAlex3İncele - MakaleAçık Erişim2023Scopus SJRQ2Exome-Wide Association Study of Competitive Performance in Elite Athletes
Bulgay, Celal; Kasakolu, Anil; Kazan, Hasan Hueseyin; Mijaica, Raluca; Zorba, Erdal; Akman, Onur; Bayraktar, Isik; Ekmekci, Ridvan; Koncagul, Seyrani; Ulucan, Korkut
The aim of the study was to identify genetic variants associated with personal best scores in Turkish track and field athletes and to compare allelic frequencies between sprint/power and endurance athletes and controls using a whole-exome sequencing (WES) approach, followed by replication studies in independent cohorts. The discovery phase involved 60 elite Turkish athletes (31 sprint/power and 29 endurance) and 20 ethnically matched controls. The replication phase involved 1132 individuals (115 elite Russian sprinters, 373 elite Russian endurance athletes (of which 75 athletes were with VO2max measurements), 209 controls, 148 Russian and 287 Finnish individuals with muscle fiber composition and cross-sectional area (CSA) data). None of the single nucleotide polymorphisms (SNPs) reached an exome-wide significance level (p < 2.3 x 10(-7)) in genotype-phenotype and case-control studies of Turkish athletes. However, of the 53 nominally (p < 0.05) associated SNPs, four functional variants were replicated. The SIRT1 rs41299232 G allele was significantly over-represented in Turkish (p = 0.047) and Russian (p = 0.018) endurance athletes compared to sprint/power athletes and was associated with increased VO2max (p = 0.037) and a greater proportion of slow-twitch muscle fibers (p = 0.035). The NUP210 rs2280084 A allele was significantly over-represented in Turkish (p = 0.044) and Russian (p = 0.012) endurance athletes compared to sprint/power athletes. The TRPM2 rs1785440 G allele was significantly over-represented in Turkish endurance athletes compared to sprint/power athletes (p = 0.034) and was associated with increased VO2max (p = 0.008). The AGRN rs4074992 C allele was significantly over-represented in Turkish sprint/power athletes compared to endurance athletes (p = 0.037) and was associated with a greater CSA of fast-twitch muscle fibers (p = 0.024). In conclusion, we present the first WES study of athletes showing that this approach can be used to identify novel genetic markers associated with exercise- and sport-related phenotypes.
AtıfScopus20WoS23OpenAlex27İncele - Derleme MakaleAçık Erişim2023Scopus SJRQ1Natural products of relevance in the management of attention deficit hyperactivity disorder
Custódio, Luisa; Vizetto-Duarte, Catarina; Cebeci, Fatma; Özçelik, Beraat; Sharopov, Farukh; Gürer, Eda Sonmez; Kumar, Manoj; Iriti, Marcello; Sharifi-Rad, Javad; Calina, Daniela
Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.
AtıfScopus11WoS10OpenAlex11İncele - MakaleAçık Erişim2023Scopus SJRQ2Evaluation of the Association of VDR rs2228570 Polymorphism with Elite Track and Field Athletes' Competitive Performance
Bulgay, Celal; Bayraktar, Isik; Kazan, Hasan Huseyin; Yildirim, Damla Selin; Zorba, Erdal; Akman, Onur; Ergun, Mehmet Ali; Cerit, Mesut; Ulucan, Korkut; Eken, Ozgur
The present study aimed to examine the vitamin D receptor (VDR), rs2228570 polymorphism, and its effect on elite athletes' performance. A total of 60 elite athletes (31 sprint/power and 29 endurance) and 20 control/ physically inactive, aged 18-35, voluntarily participated in the study. The International Association of Athletics Federations (IAAF) score scale was used to determine the performance levels of the athletes' personal best (PB). Whole exome sequencing (WES) was performed by the genomic DNA isolated from the peripheral blood of the participants. Sports type, sex, and competitive performance were chosen as the parameters to compare within and between the groups by linear regression models. The results showed no statistically significant difference between the CC, TC, and TT genotypes within and between the groups (p > 0.05). Additionally, our results underlined that there were no statistically significant differences for the association of rs2228570 polymorphism with PBs within the groups of the (p > 0.05) athletes. The genetic profile in the selected gene was similar in elite endurance, sprint athletes, and in controls, suggesting that rs2228570 polymorphism does not determine competitive performance in the analyzed athlete cohort.
AtıfScopus11WoS10OpenAlex15İncele - MakaleAçık Erişim2023Scopus SJRQ1Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats
Sevim, Cigdem; Akpinar, Erol; Aksu, Emrah Hicazi; Ömür, Ali Dogan; Yildirim, Serkan; Kara, Mehtap; Bolat, Ismail; Tsatsakis, Aristides; Mesnage, Robin; Golokhvast, Kirill S. S.
The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused a degeneration and necrosis of the spermatocytes in the tubular wall, a severe edema of the intertubular region and a hyperemia. This was concomittant to increased levels of 8-hydroxy-2 '-deoxyguanosine reflecting oxidative stress, and an increase in caspase 3 expression, reflecting apoptosis. According to our results, Saccharomyces boulardii supplementation mitigates these toxic effects. Further in vivo and clinical studies are needed to clarify the molecular mechanisms of protection. Altogether, our study reinforces the burden of evidence from emerging studies linking the composition of the gut microbiome to the function of the reproductive system.
AtıfScopus20WoS19OpenAlex24İncele - MakaleAçık Erişim2023Scopus SJRQ3Relationship of progranulin response with some physio-biochemical parameters in Akkaraman sheep
Bayraktar, Buelent; Tekce, Emre; Genç, Murat; Kaya, Hacer; Özcan, Gulbahar Boyuk; Aydemir, Seyma; Kotan, Goksad Cemil; Takma, Cigdem; Ürüsan, Hilal; Aksakal, Vecihi
Progranulin (PGRN) is a multifunctional protein that is critical in the retention of embryos in the endometrium of the uterus and the protection of cervical tissue during fetal growth. In case of PGRN release and dysfunction, cervical tissue may remodel (regeneration) and lead to the risk of abortion. Serum PGRN level in sheep and its variation according to different physiological periods and its relationship with some biochemical parameters are unknown. In this study, the relationship between early lactation, early and late pregnancy serum PGRN levels and some biochemical parameters in Akkaraman sheep was investigated for the first time. In the literature search, no similar studies were found on the relationship between early lactation, early and late pregnancy serum PGRN levels and some biochemical parameters in Akkaraman sheep. The research was carried out on 90 Akkaraman sheep reared in the same herd under the same care and feeding conditions. In the study, Akkaraman ewe were divided into 3 groups as early lactation, early pregnancy and late pregnancy. 1st group is early lactation period ewe (first 60 days of lactation), (n = 30), 2nd group is in the first period of pregnancy (on the 0-90th day of the first pregnancy (n = 30)), 3rd group is in the late pregnancy of pregnancy (100-150 days of pregnancy (n = 30)) was created. Blood samples from vena jugularis were taken before morning feeding from the animals that formed the study groups. PGRN levels in serum were determined by ELISA method. In addition, glucose, calcium (Ca), magnesium (Mg), phosphorus (P), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL) levels were analyzed in biochemistry autoanalyzer. As a result of the study, lactation and early pregnancy and late pregnancy mean serum PGRN levels were determined as 1.93, 1.78, 1.33 ng mL-1, respectively. The serum PGRN, glucose, Ca, Mg, P, TC, TG, LDL, HDL and VLDL levels of sheep with late pregnancy, early lactation and early pregnancy periods, which constitute the study groups, were found to be statistically significant (P<0.05). Our results have shown that due to the physiological role of PRGN in keeping the embryo in the endometrium of the uterine and in preserving the cervical tissue during fetal growth, there may be a useful parameter in the pursuit of the pregnancy process.
AtıfScopus4WoS4OpenAlex3İncele - MakaleYayıncıda açık erişim2023Scopus SJRQ3Investigation of endocrine response of thyroid and intestinal and adipose tissues due to the addition of Moringa oleifera essential oil in diet for quails exposed to heat stress
Bayraktar, Bulent; Tekce, Emre; Bayraktar, Sevil; Böyük, Gulbahar; Takma, Cigdem; Aksakal, Vecihi; Genç, Murat; Kaya, Hacer; Ülker, Ufuk; Gürbüz, Ahmet Burak
-In this study, we aimed to determine the effect of Moringa oleifera essential oil (MOEO) supplementation to rations of Japanese quail (Coturnix coturnix japonica) grown under heat stress (HS) on some adipokine (visfatin, adiponectin, and chemerin), intestinal (citrulline), 3,5,3 '-triiodothyronine (T3), thyroxine (T4), and thyroid-stimulation hormone (TSH) levels in the serum. For this purpose, 320 day-old male quail chicks were used. The study was conducted over 42 days, including a 7-d adaptation period and a 35-d experimental period. Eight trial groups were established, each including 10 quail: CT (control temperature, 25 celcius), MOEO 200, MOEO 400, MOEO 600, HSC (HS control), SMOEO 200, SMOEO 400, and SMOEO 600. Based on the results, a dose-dependent decrease was observed on days 21 and 42 in serum adiponectin and T3 in the stress and stress-free groups compared with the control group due to MOEO supplementation. The lowest decrease was observed in the MOEO 600 mg/kg dose group. In addition, an increase in stressed groups was observed when examining serum citrulline levels, while chemerin levels did not have a statistically significant effect. While the decrease in serum visfatin, T4, and TSH levels on the 21st day did not have a statistically significant effect, a significant effect was determined on the 42nd day. The addition of MOEO at 600 mg/kg to the ration may be beneficial in preventing intestinal damage and inflammation that may occur due to HS.
AtıfScopus14WoS15OpenAlex19İncele - MakaleAçık Erişim2022Development of Sustainable Event Awareness Scale: Validity and Reliability Study
Adatepe, Eda; Kolayiş, Hakan
This research was conducted with the aim of developing a measurement tool that measures the sustainable event awareness of individuals participating in sports activities. An item pool was created with the literature, expert opinions and field workers. This research group consisted of trainers, athletes, physical education and sports teachers, referees, sports managers and technical staff in Turkey who participated in national and international sports events. 812 volunteers participated in this research. Data was collected with Google Forms. It is a descriptive study designed according to the general scanning model. Explanatory and confirmatory factor analyzes were conducted for the scale called “Sustainable Event Awareness Scale” (SEAS). As a result of the analysis, 24 items with construct validity were included in the final scale. It has been determined that the scale is gathered under a total of four factors: support, performance evaluation, system structure and processes. The Cronbach Alpha internal consistency coefficient was found to be .936 for the entire scale, and it was concluded that the scale was reliable and that the scale, which has a four-dimensional structure, measures the targeted features in all sub-dimensions and is valid. As a result, this scale, which has been developed, can be used as a valid and reliable scale that measures the features that are desired to be measured in accordance with the purpose of the research.
AtıfOpenAlex2
İncele - MakaleAçık Erişim2022A Case Study of Preschool (5 Years Old) Children's Recognition of Length
Guven, Nazmiye Dilsad
In this study, it is aimed to examine preschool children's skill to recognize the quality of length. For this purpose, semi-structured clinical interviews were conducted with Merve, a 5-year-old girl, and Merve's skill to recognize length was examined. Merve's understanding of different representations of quality, recognizing, showing, identifying and comparing objects according to these representations were investigated. Different representations of the quality of length consist of long-short, wide-narrow, thick-thin, high-low, deep-shallow concepts, which are also aimed by the preschool curriculum. The study is a case study with a qualitative design. Data collected by audio and video recording through clinical interviews completed in two sessions were analyzed using content analysis method. It can be said that Merve can recognize long-short, and height representations, make correct comparisons, and use relevant terms appropriately. However, it has been observed that the skill to recognize the concepts of thick-thin, wide-narrow, deep-shallow is based on intuitive facts and is not yet mature.
