Sürdürülebilir Kalkınma Amaçları

Yazarlar

  • MakaleAçık Erişim2026Scopus SJRQ2
    Exploring the ımpact of metal doping and alternative electrodes on the performance of dye-sensitized solar cells

    Calıskan, Berrak; Sayan, Enes; Igman, Erdal

    This study explores the synthesis and characterization of metal-doped TiO2 thin films for applications in dye-sensitized solar cells (DSSCs). Titanium dioxide (TiO2) films were doped with various metal ions such as Ag+, Zn2+, Fe3+, and Co2+, to enhance the photoelectrochemical properties of the photoanode. The films were characterized using various techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), UV–Vis spectroscopy, and X-ray photoelectron spectroscopy (XPS). The doping process was found to influence the morphology, surface area, and optical properties of the TiO2 films, resulting in enhanced light absorption, particularly in the visible range. The effects of metal doping on the performance of the DSSCs were evaluated, showing that Co2+ and Ag+ doping resulted in improved efficiency compared to undoped TiO2, with the Co2+-doped TiO2 achieving the highest power conversion efficiency of 2.85%. Additionally, the incorporation of reduced graphene oxide (rGO) as a counter electrode demonstrated a significant enhancement in DSSC performance, even surpassing traditional platinum-based counter electrodes. The results suggest that metal doping and rGO incorporation offer promising strategies for improving DSSC efficiency. This study highlights the potential of metal-doped TiO2 photoanodes and rGO counter electrodes in advancing the development of cost-effective, high-performance DSSCs for sustainable solar energy applications.

    • SDG 7 · Erişilebilir ve Temiz Enerji
    AtıfScopus1WoS1
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2026Scopus SJRQ3
    Molecular structure, spectral characteristics, and nonlinear optical properties of labetalol: an experimental and computational investigation

    Çınar, Mehmet; Can, Sümeyra

    Labetalol is an antihypertensive agent that possesses both α- and β-adrenergic blocking properties. This characteristic allows for its clinical use in both chronic hypertension and hypertensive emergencies. In this study, the FT-IR, FT-Raman, 1 H, 13 C, and DEPT-135 NMR spectra of labetalol hydrochloride (Labetalol HCl) were recorded and examined. Furthermore, the pharmacologically active (R, R) stereoisomer of labetalol was theoretically investigated using the B3LYP functional and the 6-311++G(d, p) basis set. The theoretically determined ground-state geometry of the molecule showed excellent agreement with experimental data reported in the literature. Using the obtained optimized structure, the vibrational spectra of the molecule were simulated, and the vibrational modes were assigned by evaluating them together with the experimental data. Nuclear Magnetic Resonance (NMR) analysis of the molecule was performed considering experimentally recorded values and calculations for gas phase, DMSO, and chloroform solvent environments, and the chemical shift values for each H and C atom were determined. Using Time-Dependent Density Functional Theory (TD-DFT) and Solvation Model based on Density (SMD) approaches, the UV-Vis spectra of the molecule were obtained in the gas phase and in four different solvent environments (ethanol, methanol, DMSO, and water). To better understand the electronic properties of the molecule, Frontier Molecular Orbitals (FMO), Molecular Electrostatic Potential Surface (MEPS), Hirshfeld surface analysis, Mulliken and Hirshfeld charge distributions, and Density States (DoS) analyses were performed. In addition, the non-linear optical (NLO) properties of the molecule were theoretically calculated, and the results showed that the molecule could be a promising NLO candidate.

  • MakaleAçık Erişim2026Scopus SJRQ2
    Rhodanine–Sulfonate hybrids targeting aldose reductase: Synthesis, in vitro inhibition, molecular docking, and cytotoxicity studies

    Kalay, Erbay; Demir, Yeliz; Türkeş, Cüneyt; Aslan, Osman Nuri; Pezik, Esra; Şahin, Engin

    Aldose reductase (ALR2), a key enzyme in the polyol pathway, plays a significant role in the onset and progression of diabetic complications, rendering it a critical pharmacological target. In this study, a novel series of twenty-four sulfonate ester-functionalized rhodanine derivatives (compounds 1–24) were rationally designed, synthesized via Knoevenagel condensation, and comprehensively evaluated for their inhibitory activity against ALR2. Spectroscopic and spectrometric methods confirmed the structural integrity of the synthesized compounds. In vitro enzyme inhibition assays revealed that all compounds acted as competitive inhibitors, with several analogues, particularly compounds 6 and 8, exhibiting stronger ALR2 inhibition (Ki = 0.43 µM and 0.48 µM, respectively) than the reference drug epalrestat (Ki = 0.98 µM). Structure–activity relationship (SAR) analysis highlighted the critical influence of para-substituted electron-donating (e.g., methyl) and electron-withdrawing (e.g., nitro, halogen) groups on binding potency. Molecular docking of the most potent inhibitor (compound 6) demonstrated a stable binding pose supported by key interactions, including hydrogen bonding with His110 and π–π stacking with Phe122. In silico ADME profiling confirmed favorable drug-likeness properties for all derivatives. Cytotoxicity studies on L929, A549, and RG-2 cell lines revealed that most compounds were less toxic than the reference drug at lower concentrations, with compound 8 showing a promising cytotoxic profile. These findings position rhodanine–sulfonate hybrids as promising scaffolds for the development of next-generation ALR2 inhibitors for the treatment of diabetic complications.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus2WoS3
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2026Scopus SJRQ1
    Dietary chokeberry (Aronia melanocarpa) supplementation improves colony development, nutritional status, antioxidant defences, and honey production in honey bee colonies

    Erdoğan, Yaşar; Erdoğan, Ümmügülsüm

    This study evaluated the effects of chokeberry (Aronia melanocarpa) fruit powder as a functional dietary supplement for honey bee (Apis mellifera) colonies, focusing on colony development, antioxidant defences, nutritional status, behaviour, and honey yield under field conditions. A total of 48 colonies were randomly assigned to four feeding treatments (control, 2, 5, and 10 g L−1 chokeberry supplementation), with six colonies per treatment in each apiary (n = 6 per apiary; n = 12 per treatment). The experiment was conducted as a balanced field trial across two apiaries. Colonies were fed sucrose syrup supplemented with chokeberry powder for 21 days. Following the feeding period, colonies were transferred to two high-altitude summer apiaries where colony development, flight activity, defensive behaviour, antioxidant biomarkers, and end-of-season honey yield were evaluated. Results demonstrated that chokeberry supplementation significantly improved colony development, with significant dose effects on brood area and bee-covered frames (both p < 0.001). Flight activity also increased with supplementation dose (p < 0.001), whereas defensive behaviour was not affected. Total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT) activity, and haemolymph total protein concentration all increased significantly with supplementation (all p < 0.001). End-of-season honey yield was significantly higher in supplemented colonies than in the control group (p < 0.001). Overall, these findings demonstrate that chokeberry fruit powder represents a promising functional dietary supplement capable of improving colony performance through the combined contribution of its nutritional composition and bioactive phytochemicals under practical field conditions.

    • SDG 2 · Açlığa Son
  • MakaleYalnız künye2026Scopus SJRQ3
    Synthesis and cytotoxic activity studies of novel heterocyclic thiosemicarbazone compounds as anticancer agents

    Güllü, Eda; Hasanoğlu Özkan, Elvan; Kızıl, Hamit Emre; Nartop, Dilek

    Herein, novel heterocyclic thiosemicarbazone compounds (Hb1, Hb2, Hb3) containing pyrimidine, imidazole, pyridine, and phenyl rings were synthesized via the condensation method as potential therapeutic agents for the treatment of non-small cell lung cancer. The structure of novel heterocyclic compounds was elucidated by using some spectroscopic techniques (organic elemental analysis, fourier transform infrared spectroscopy, proton/carbon nuclear magnetic resonance spectroscopy, scanning electron microscopy and energy dispersive X-ray image, and molar conductance measurement). The antiproliferative activity of novel heterocyclic thiosemicarbazone compounds using CVDK-8 cell viability assay. The viability assay was examined against A549 human non-small cell lung cancer cell line. All heterocyclic thiosemicarbazone compounds exhibited varying degrees of dose-dependent cytotoxic activity against A549 NSCLC cells. The results showed that the pyridine-based heterocyclic compound (Hb3) was the most potent antiproliferative agent, demonstrating a dose-dependent reduction in cell viability at concentrations of 50 µg/mL and higher.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
  • MakaleYayıncıda açık erişim2026Scopus SJRQ1
    Turkish validation of the CompACT: assessing psychological flexibility among emergency aid and disaster management students

    Çınar, Öznur; Oral, Vildan; Turan, Melikşah; Cengiz, Ekrem

    Psychological flexibility is a central construct in Acceptance and Commitment Therapy and an important protective factor for mental health, particularly among individuals expected to function effectively under high stress and uncertainty, such as those in emergency aid and disaster management. Despite its relevance for this population, no Turkish version of the Comprehensive Assessment of Acceptance and Commitment Therapy Processes (CompACT) had been available. The present study aimed to perform a cross-cultural adaptation of the English version of CompACT into Turkish and to evaluate its psychometric properties in emergency aid and disaster management students. The study was conducted in two phases: translation and cross-cultural adaptation, followed by psychometric evaluation in a sample of 302 students. Data were analyzed using SPSS v.21 and AMOS v.22 through exploratory and confirmatory factor analyses, reliability analyses, test-retest analysis, and correlational validity testing. The exploratory factor analysis (EFA) showed that the CompACT consisted of three factors (Openness to Experience, Behavioral Awareness, and Valued Action) explaining 75.848% of the total variance, comprising 20 items. Confirmatory factor analysis (CFA) showed that the three-factor model provided the best fit to the data (χ²/df = 2.590, CFI = 0.963, TLI = 0.956, RMSEA = 0.073). The scale demonstrated satisfactory internal consistency (overall alpha = 0.843) and temporal stability (test-retest r > 0.70 across all subscales), and its expected negative associations with the Acceptance and Action Questionnaire-II (r = −0.365) and the Depression Anxiety Stress Scales-21 (r = −0.403) supported its criterion-related validity.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus1WoS1OpenAlex1
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2026Scopus SJRQ2
    The effect of practising sports on communication skills in medical students

    Kaşali, Kamber; Badicu, Georgian; Al-Mhanna, Sameer Badri; de Sousa Fernandes, Matheus Santos; Şeran, Buket; Akman, Onur

    Effective communication is essential for medical students in terms of patient interaction, teamwork and professional success. This study examines the effect of doing sports on the communication skills of medical students. Three hundred forty-five medical students participated in the study and their communication skills were assessed using the Effective Communication Skills Scale. The findings revealed a significant difference between Turkish and English students in terms of 'Using I Language' skills. In addition, when the students' beliefs about the physical, physiological and psychological benefits of sports were compared with the sub-dimensions of the scale, statistically significant differences were found in the sub-dimensions of "Ego Enhancing Language" (p = 0.011), "Empathy" (p = 0.047) and "Using I Language" (p = 0.005). When the relationship between the class levels of the students and the sub-dimensions of the scale was examined, significant differences were observed in the sub-dimensions of 'Ego Enhancing Language' (p = 0.001), 'Active Listening' (p = 0.011) and 'Using I Language' (p = 0.007). The findings show that doing sports is essential in improving medical students' communication skills and suggest that encouraging sports in the medical education process may be beneficial in enhancing communication competencies.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 4 · Nitelikli Eğitim
    AtıfOpenAlex1
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2026Scopus SJRQ3
    The impact of ChatGPT-integrated reading activities on the reading attitudes and habits of middle school students

    Kaplan, Kadir; Özen, Nesime Ertan; Özcan, Halil Ziya

    This study examines the impact of the artificial intelligence tool ChatGPT on middle school students' attitudes and reading habits during a brief intervention. Twenty-six students from a middle school in Türkiye—13 in the experimental group and 13 in the control group—took part in an eight-session, four-week quasi-experimental study. Both quantitative and qualitative data were collected using a sequential explanatory mixed-methods approach. Data was gathered and analyzed using the Attitudes and Habits towards Reading Scale, the Digital Literacy Scale, and focus group interviews. Preliminary results indicate that students in the experimental group had better reading habits and attitudes than those in the control group. After the ChatGPT intervention was implemented, the experimental group's students showed a significant improvement in their positive attitudes toward reading. However, the experimental group also showed an unexpected increase in negative reading attitudes, warranting further investigation. Three primary themes, covering both the advantages and disadvantages of the application, were identified from the student interview data. These results highlight how artificial intelligence (AI) technologies present a potentially novel way to boost reading motivation in educational settings. However, to use these technologies effectively, educators and students must acquire more knowledge and skills. Longer-term studies with larger sample sizes are also required to validate these initial findings.

    • SDG 4 · Nitelikli Eğitim
    AtıfScopus3OpenAlex3
    Scopusİncele
  • Derleme MakaleAçık Erişim2026Scopus SJRQ1
    A Meta-Analysis of Self-Management Strategies to Enhance Educators’ Teaching Performance

    Aydin, Orhan; Ari-Arat, Ceren; Sulu, Mehmet D.

    This meta-analysis examines the effectiveness of self-management strategies in enhancing the teaching performance of educators, with a focus on special education contexts. Thirty-six studies, including peer-reviewed articles and gray literature, were evaluated for methodological rigor using the What Works Clearinghouse (WWC) Design Standards. Of these, 26 studies meeting the standards with or without reservations were further analyzed using descriptive review, meta-analysis, and moderator analysis. Findings revealed self-monitoring is the most frequently used self-management strategy. Among the educators included in the studies, the majority were special education teachers. Effect sizes were calculated using Tau-U for all 26 studies, between-case standardized mean difference (BC-SMD) for 25 studies, and performance-criteria-based effect size (PCES) for 13 studies reporting a mastery criterion. The overall Tau-U indicated a very large effect size of 0.88 (CI95 = [0.74, 1]), and BC-SMD resulted in a large effect size of 0.87 (CI95 = [0.77, 0.98]). The PCES showed an overall effective effect size of 1.15 (CI95 = [1.07, 1.23]). Moderator analysis revealed behavior-specific praise, and fewer years of teaching experience were associated with higher teaching performance effect sizes compared to other relevant categories; however, years of teaching experience and higher teaching performance were positively associated when using BC-SMD calculations. Detailed findings along with corresponding recommendations are discussed. © Hammill Institute on Disabilities 2026. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

    • SDG 4 · Nitelikli Eğitim
  • MakaleYalnız künye2026Scopus SJRQ1
    Optimization of Antioxidant Recovery from Deep Eutectic Solvent Phase via Back-Extraction Using Taguchi Method

    Kamiloğlu, Aybike; Elbir Abca, Tuğba; Kutlu, Naciye

    This study investigates the use of deep eutectic solvents (DESs) via ethyl acetate-mediated liquid–liquid extraction and the optimization of the process using the Taguchi method for the recovery of antioxidant compounds from tea industry waste. In the study, choline chloride was used as a hydrogen bond acceptor; lactic acid, glycerol, and ethanol were used as hydrogen bond donors; and different ratios of water (10–30%) were added to reduce the viscosity of the DESs. Ultrasound-assisted extraction results showed that lactic acid-based DESs provided the highest total phenolic content and antioxidant activity due to their ability to break down plant cell walls. However, in the recovery phase carried out with ethyl acetate, it was determined that ethanol-based DESs (ChCl:EtOH) were more effective in transferring antioxidants to the organic phase due to their looser molecular structure. Optimization using the Taguchi L9 orthogonal array revealed the following results: ChCl:EtOH solvent, 2:1 ethyl acetate/extract ratio, 20% water ratio, and 30-min shaking period were determined as the optimal conditions. Under these conditions, the model predicted a yield of 93.34%, and experimental validation revealed a recovery yield of 85.70 ± 1.13%. The results demonstrate that this developed green extraction method offers a sustainable alternative for converting tea waste into high value-added functional components.

    • SDG 12 · Sorumlu Üretim ve Tüketim
  • MakaleAçık Erişim2026Scopus SJRQ1
    A Single-Source Pilot Study of Machine Learning-Assisted Microwave S-Parameter Screening for Glucose Syrup and Water Adulteration in Grape Molasses

    Engin, Mustafa Alptekin; Cakir, Mehmet; Cakil, Turan

    Grape molasses, known as pekmez in Turkish, is a traditional concentrated fruit product that may be adulterated with cheaper sweeteners or water. This study evaluated broadband microwave S-parameter measurements as a rapid, non-destructive screening approach for detecting glucose syrup substitution and water dilution in grape molasses. Nine physical mixture groups were prepared, including pure grape molasses, glucose syrup–substituted mixtures at 5–30%, pure glucose syrup as an endpoint reference, and water-diluted mixtures at 10–30%. For each group, five consecutive technical measurements were recorded using a Libre vector network analyzer connected to a WR-229 waveguide-based two-port setup over 3.30–4.90 GHz. All mixtures were prepared from a single commercial grape molasses source and a single glucose syrup source; the results should therefore be interpreted as pilot-scale, single-source evidence rather than a generalizable screening method. Glucose syrup substitution produced a systematic upward shift in S11 resonance frequency. In the practical 0–30% range, S11 resonance frequency showed a strong linear relationship with glucose syrup content on the calibration data (R2 = 0.9955; inverse prediction error = 0.72 percentage points), though this reflects calibration fit rather than independently validated prediction accuracy. Water dilution produced stronger S21 attenuation. The detection principle is based on the complementary use of S11 resonance behavior for glucose syrup substitution and S21 transmission loss for water dilution. In group-blocked point-wise classification, the Ensemble Bagged Trees classifier achieved 88.79% accuracy and a macro-F1 score of 0.874. These results indicate that S11 and S21 provide complementary proof-of-concept indicators for controlled-mixture screening of grape molasses adulteration.

    • SDG 2 · Açlığa Son
  • MakaleAçık Erişim2026Scopus SJRQ2
    Modulation of stress and neuroplasticity biomarkers via rhythmic vocalization: a controlled study on NDNF, cortisol, and monoamines

    Okur, Süheyb; Bayraktar, Bülent

    Background: The aim of this study is to investigate the effect of reciting the Quran (from Mushaf) on serotonin, dopamine, NDNF, and cortisol levels in relation to mental well-being. Methods: This study was conducted on a sample of university students who know how to read the Quran in Türkiye, selected by a non-probability method, with a pre-test-post-test control group and a longitudinal design; the assignment to the groups was also done randomly. The research was carried out with 72 university students (36 female, 36 male), aged 19–30, who know how to read the Quran and do not have any health problems. Two groups were formed: a 36-person experimental group and a 36-person passive resting control group. The Mental Well-Being Scale and a personal information form were used to evaluate the participants’ well-being status. Salivary serotonin, dopamine, NDNF, and cortisol levels were examined using the ELISA technique in samples taken before and after the experimental group recited verses 195–200 of Surah Al-i Imran aloud. Number, percentage, mean, Pearson correlation, and ANOVA tests were used to evaluate the data. Statistical significance was accepted as p <.05 for all analyses. Results: A significant group-time interaction was found (p <.05). Compared to the passive resting control group, the experimental group showed statistically significant increases in salivary serotonin, dopamine, and NDNF levels, and a significant decrease in cortisol levels. However, a critical dissociation was observed: despite this neuroprotective biomarker profile, the control group reported statistically significantly higher post-intervention mental well-being scores than the experimental group (p <.05). This suggests that the acute cognitive load and performance anxiety associated with the recitation task may temporarily mask physiological benefits in self-reports. Conclusions: A brief (5-minute) ‘Tartil’ recitation of the Quran demonstrates immediate, positive neurobiological effects by reducing stress hormones (cortisol) and increasing reward- and neuroplasticity-related biomarkers (dopamine, serotonin, NDNF). However, this did not immediately translate to higher self-reported well-being, suggesting the relationship between the neurobiology of recitation and its perceived psychological effects is complex and potentially confounded by factors such as performance anxiety or cognitive load in an experimental setting. Clinical trial number: Not applicable.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus2WoS3OpenAlex4
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2026Scopus SJRQ1
    Depression and psychiatric help-seeking as joint outcomes: a Bayesian multilevel analysis of household-level dependence

    Camadan, Fatih; Yıldız, Mehmet Selim; Şahin, Hatice Büşra; Urak, Faruk; Börekçi, Taha Berkay; Bilgiç, Abdulbaki

    Background: Depression and the utilization of psychiatric services (PSU) are complex mental health outcomes shaped by a wide range of individual, familial, and socioeconomic factors. However, within the context of Türkiye, limited attention has been devoted to the simultaneous modeling of these outcomes and to the systematic examination of their shared household-level determinants. Methods: This study conducts a concurrent analysis of two binary outcomes—self-reported depression and receipt of professional psychiatric care within the past 12 months—using data from a nationally representative household survey. The analytical sample comprises 22,742 individuals nested within 10,028 households across Türkiye. A Bayesian multilevel bivariate logistic regression model was employed to account explicitly for the hierarchical structure of the data, with individuals nested within households. Household-level random intercepts were specified for both outcomes, and the correlation between the latent processes underlying depression and PSU was directly estimated. Weakly informative priors were adopted, and model estimation was performed using the No-U-Turn Sampler (NUTS), an efficient variant of the Hamiltonian Monte Carlo algorithm. Results: The results reveal pronounced clustering of both depression and PSU at the household level. A strong positive correlation between household-level random effects indicates that individuals experiencing depression are substantially more likely to utilize psychiatric services within the same family context. At the individual level, men are significantly less likely than women to report depressive symptoms or to seek psychiatric care. Tobacco and alcohol use are positively associated with depression risk, whereas adequate rest and healthier lifestyle behaviors exhibit protective effects. Increases in body mass index (BMI) are associated with a higher likelihood of depression. In contrast, active employment and higher household income are linked to reduced depression risk. Additionally, a range of sociodemographic and economic characteristics exert significant effects on both depression and PSU. Conclusions: These findings demonstrate that depression and psychiatric service utilization (PSU) are shaped not only by individual-level characteristics but also by shared familial and structural factors. The results underscore the need for mental health policies that move beyond narrowly individual-centered frameworks and instead adopt holistic strategies that incorporate household dynamics and broader socioeconomic conditions.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
  • MakaleAçık Erişim2026Scopus SJRQ1
    Adverse childhood experiences and problematic gambling among young adults: a moderated serial mediation analysis

    Yayla, İbrahim Erdoğan; Makas, Samet; Dombak, Kübra; Bekir, Seyhan; Çelik, Eyüp; Arpaci, Ibrahim; Baloglu, Mustafa

    Problem gambling is a serious public health issue among young adults today and the literature suggests that adverse childhood experiences may be associated with it. Additionally, difficulties in emotion regulation and self-control may contribute to the association between problem gambling and adverse childhood experiences. Sensation seeking and a family history of gambling may also influence these relationships. Hence, we examined the relationship between adverse childhood experiences and problem gambling among young adults. We analyzed the collected data from 579 young adults (18–29 years old, 67.5% male) via an online survey using a cross-sectional research design. More specifically, we tested the serial mediating roles of difficulties in emotion regulation and self-control, as well as the moderating roles of sensation seeking and a family history of gambling. We found a significant positive association between adverse childhood experiences and problem gambling. Both difficulties in emotion regulation and self-control had significant mediating effects. Sensation seeking and family history of gambling moderated the mediating effects, strengthening the pathways leading to problem gambling at higher levels of sensation seeking and in the presence of family gambling history. These findings indicate that emotion regulation and self-control are important psychological processes in explaining the relationship between adverse childhood experiences and problem gambling. They also suggest that high sensation seeking and a family history of gambling may strengthen the relationships.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 16 · Barış, Adalet ve Güçlü Kurumlar
  • MakaleAçık Erişim2026Scopus SJRQ1
    Ultrasonic-Assisted Deep Eutectic Solvent Extraction of Polyphenols From Tea Parts: A Green Assessment

    Gerçek, Yusuf Can; Baştürk, Fatma Nur; Gıdık, Betül; Abca, Tuğba Elbir; Yurtvermez, Bayram; Fuente-Ballesteros, Adrián; Kutlu, Naciye; Ecem Bayram, Nesrin

    Deep eutectic solvents (DESs) have emerged as green alternatives to conventional solvents for extracting bioactive compounds from plants. This study evaluated nine choline chloride–based DESs for recovering antioxidant polyphenols from four parts of the tea plant (Camellia sinensis): seed, bud, leaf, and flower. Total phenolic content, antioxidant activity, and individual polyphenolic profiles were determined, and the greenness of the sample preparation was assessed using AGREEprep. The highest total phenolic content (53.28 mg GAE/g) and antioxidant activity (141.17 mg TE/g) were obtained from leaves using ChCl:formic acid, outperforming ethanol and methanol. Leaves also exhibited the highest total quantified polyphenolic content (up to 95,813 mg/kg DW, corresponding to the sum of the quantified polyphenols), with epicatechin gallate and gallocatechin + epigallocatechin being the major contributors. Flowers and buds showed notable polyphenolic diversity, while seeds contained the lowest levels. Statistical analysis confirmed clear clustering patterns according to plant part and solvent type. AGREEprep evaluation yielded scores up to 0.54, highlighting the environmental benefits of DES-based extraction. We demonstrated that tea leaves were the richest source of bioactive polyphenols, and selected DESs, particularly formic acid–based and ethylene glycol–based, exhibited superior efficiency and sustainability compared to conventional solvents. These findings support the wider adoption of DESs for green, high-yield extraction of pharmacologically important compounds from tea and other medicinal plants.

    • SDG 12 · Sorumlu Üretim ve Tüketim
  • MakaleAçık Erişim2026Scopus SJRQ1
    Performance level controlled efficiency of graphene nanoplatelets in cementitious composites

    Şahin, Yaren; Öksüzer, Nurullah; Kütük, Sezai; Gökçe, Hacı Süleyman

    Graphene nanoplatelets (nGP) have been widely reported as effective nano-reinforcements for cementitious composites; however, their optimal dosage remains inconsistent across existing studies. This variability is commonly attributed to nanomaterial-related parameters, whereas the influence of the cementitious matrix’s inherent performance is rarely systematically examined. In this study, cementitious matrices with distinct performance levels were designed by varying water-to-binder ratios (0.55, 0.40, and 0.30) and incorporating silica fume. Their interaction with nGP was experimentally investigated, with contents up to 2.4% being used. A total of 25 mix designs were evaluated for fresh-state behavior, mechanical performance, transport properties, and microstructural characteristics. The results indicate that the efficiency and optimal utilization of nGP are strongly governed by the matrix performance level. High-performance matrices (water-to-binder (w/b) = 0.30, 11% silica fume) achieved peak performance at 1.2% nGP, yielding compressive strength of 118.2 MPa and up to 50% reduction in capillary water transport, whereas low-performance matrices (w/b = 0.55) exhibited limited sensitivity to nGP incorporation. Microstructural observations confirmed that matrix densification improved nGP integration and hierarchical pore refinement by enhancing interfacial bonding, thereby restricting capillary water transport. The findings demonstrate that optimal nGP dosage cannot be treated as an intrinsic material parameter and should instead be defined in relation to matrix performance level, enabling performance-based dosage guidelines for nano-engineered composites in high-durability applications.

    • SDG 9 · Sanayi, Yenilikçilik ve Altyapı
    AtıfWoS1OpenAlex1
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2026Scopus SJRQ3
    Chemical Profiling of Stachys cretica subsp. anatolica Rech. f. (Endemic) Essential Oils and their Methanol Extracts with Evaluation as Enzyme Inhibitors, Antioxidant, and Antimicrobial Agents

    Öz, Mehmet; Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman; Aygül, İmdat

    Enzyme inhibition activities, phenolic compounds, antioxidant activities, bioactive compounds, antimicrobial activities, and chemical components of essential oil and methanol extracts obtained from the aerial parts of S. cretica subsp. anatolica were investigated. The main phenolic compounds of aerial parts were catechin, oleuropein, and epicatechin. The determined enzyme inhibitor activities highlight the potential of S. cretica subsp. anatolica as a source of bioactive compounds, particularly for carbonic anhydrase and cholinesterase inhibition. The essential oil and methanol extract exhibited remarkable activities against CA-II, AChE, and BChE, although they were less potent than standard inhibitors. The essential oils generally showed stronger antimicrobial activity compared to the 30% methanol extracts across most bacterial and fungal strains, as evidenced by minimum lethal concentration (MLC) and lower minimum inhibitory concentration (MIC) values and larger inhibition zones. Chloramphenicol used alone exhibited the highest antimicrobial efficacy, with the lowest MIC and MLC values and the largest inhibition zones. The essential oils of S. cretica subsp. anatolica were determined as esters, oxygenated sesquiterpenes, and aldehydes in aerial parts. The main components were found to be hexahydrofarnesyl acetone in the aerial parts.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus3WoS3OpenAlex1
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2026Scopus SJRQ1
    Examining the relationships between artificial intelligence literacy, AI-TPACK, job satisfaction, and well-being among teachers through structural equation modeling

    Kayalı, Bünyami; Balat, Şener; Yavuz, Mehmet

    This study explores the relationships between teachers' artificial intelligence literacy (AIL), AI-TPACK competencies, job satisfaction, and well-being. Survey data from 350 in-service teachers were analyzed using PLS-SEM to examine how AI-related competencies are associated with professional and psychological outcomes. The findings reveal that AIL strongly predicts AI-specific knowledge, especially AI-TCK, AI-TK, AI-TPCK, and AI-TPK, with a moderate influence on traditional pedagogical knowledge. At the job satisfaction level, AI-TCK and general pedagogical knowledge are positively associated with satisfaction, while AI-TK has a negative relationship. Mediation analyses show that AI competencies influence well-being through job satisfaction. AI-TCK and pedagogical knowledge are positively associated with well-being indirectly through job satisfaction, whereas AI-TK shows a negative indirect association along the same pathway. The study suggests that AI-related competencies are linked to teachers' work-life outcomes, and highlights job satisfaction as the key mediator between AI competence and well-being. Because the design is cross-sectional and self-reported, these relationships are interpreted as associations rather than causal effects. The study advocates for integrating AI in ways that support pedagogical development rather than just technical skills.

    • SDG 4 · Nitelikli Eğitim
    • SDG 8 · İnsana Yakışır İş ve Ekonomik Büyüme
  • MakaleAçık Erişim2026Scopus SJRQ1
    Comparative thermal and hydraulic performance of Type-22 panel radiators under continuous and pulsating flow

    Köksal, Hüseyin; Ceviz, Mehmet Akif; Muratçobanoğlu, Burak; Mandev, Emre

    Pulsating water-side flow has been proposed as a radiator control strategy to enhance heat emission at low supply temperatures, yet device-level studies rarely quantify thermal gains together with hydraulic costs under matched baselines. This study experimentally investigates the coupled thermal and hydraulic response of a PCCP Type-22 panel radiator operated under continuous and on–off pulsating flow regimes. A dedicated test loop was developed using a temperature-controlled hot-water tank (50 °C setpoint) and an Arduino-based driver to impose repeatable pulsation, while measuring inlet/outlet temperatures, instantaneous flow rate, pump electrical energy, and spatiotemporal surface temperatures via infrared thermography. The results show that increasing the continuous flow rate provides the highest absolute heat output, but at the cost of increased pumping energy. In contrast, pulsating operation improves the thermal–hydraulic balance by increasing heat delivery relative to the reference case while reducing pump energy consumption. Among the tested pulsating cases, short-period pulsation produced the most favorable behavior by maintaining a warmer and more spatially stable radiator surface. Longer off-periods promoted deeper surface cooling, reduced the effective emitting area, and weakened the thermal benefit of pulsation. Infrared thermography confirmed that the pulsation period strongly affects surface-temperature uniformity and temporal stability. Overall, short-period on–off pulsation emerges as the most favorable operating mode when the objective is to increase heat delivery while lowering pumping energy in PCCP-type radiators.

    • SDG 7 · Erişilebilir ve Temiz Enerji
  • MakaleYalnız künye2026Scopus SJRQ4
    SURFACE ROUGHNESS AND SHORE-D HARDNESS OF SIX TROPICAL HARDWOODS; [RUGOSIDADE DA SUPERFÍCIE E DUREZA SHORE-D DE SEIS MADEIRAS TROPICAIS]; [RUGOSIDAD SUPERFICIAL Y DUREZA SHORE-D DE SEIS MADERAS TROPICALES]

    Ayata, Umit; Domingos, Idalina; Ferreira, José; Cruz-Lopes, Luísa; Esteves, Bruno

    Introduction: This study investigates the Shore-D hardness and surface roughness characteristics of six tropical wood species: Canelo (Nectandra spp.), Limbali (Gibertiodendron dewevrei), Difou (Morus mesozygia), Curupay (Anadenanthera macrocarpa), Ebiara (Berlinia bracteosa), and Zwarte kabbes (Diplotropis martiusii), aiming to assess their suitability for high-performance applications. Objective: To evaluate how wood species and sanding processes influence the mechanical properties and surface quality of selected tropical woods. Methods: Samples were conditioned and sanded using abrasives of different grit sizes (80, 100, 120, 150, and 180). Surface roughness parameters Ra, Rq, and Rz, as well as Shore-D hardness, were measured. Statistical analyses were performed using ANOVA and Duncan’s test. Results: Statistical analysis revealed that abrasive grit size significantly affected surface roughness (p < 0.001), with finer grits producing smoother surfaces. Wood species also had a significant effect on both roughness and hardness. Sanding had the greatest influence on Ra, Rq, and Rz parameters. Ebiara exhibited the smoothest surface, while Curupay showed the highest hardness (74.65). Conclusion: Surface roughness is primarily influenced by sanding grit, whereas hardness is determined by wood species. The results emphasize the importance of tailoring sanding procedures to the wood species in order to optimize surface quality and mechanical performance in industrial and decorative applications.