Yazarlar
- Bayraktar, Bülent(33)
- Dertli, Enes(33)
- Dirican, Ebubekir(20)
- Akeren, Zahide(18)
- İspirli, Hümeyra(18)
- Kizil, Hamit Emre(17)
- Semerci, Vahide(14)
- Bayram, Sinan(13)
- Kul, Murat(13)
- Sönmez Sarı, Ebru(13)
- Agar, Guleray(12)
- Akman, Onur(12)
- Kırbaş, Zila Özlem(12)
- Akeren, İhsan(11)
- Koçak, Lokman(11)
- Makas, Samet(11)
- Can, Zehra(10)
- Uzunçakmak, Sevgi Karabulut(10)
- Yayla, İbrahim Erdoğan(10)
- Çelik, Eyüp(10)
- Bayraktar, B.(9)
- Bulbuloglu, Semra(9)
- Kızıl, Hamit Emre(9)
- Tekce, Emre(9)
- Aydemir, Uğur(8)
- Daştan, Buket(8)
- Hintistan, Sevilay(8)
- Kalyoncuo, Servet(8)
- Sönmez Sari, Ebru(8)
- Türkmen, Mutlu(8)
- Apaydın, Emine(7)
- Arslaner, Ayla(7)
- Beydemir, Şükrü(7)
- Dombak, Kübra(7)
- Kara, Yakup(7)
- Mercan, Emin(7)
- Semerci Çakmak, Vahide(7)
- Can, Özgür Devrim(6)
- Esgin, Özge(6)
- Güneş, Hüseyin(6)
Yayınlar
- MakaleYalnız künye2024Scopus SJRQ3Exploring the Potential of Isoindole-1,3-Dione Derivatives as Novel Inhibitors of Aldose Reductase: An In Silico and In Vitro Insight into Therapeutic Strategies for Diabetic Complications
Şengül, Bülent; Gündoğdu, Özlem; Kilinç, Namık; Kishali, Nurhan
This study explores the potential of isoindole-1,3-dione derivatives as novel inhibitors of aldose reductase (AR), focusing on their in silico and in vitro effects for therapeutic strategies against diabetic complications. Aldose reductase, a critical enzyme in the polyol pathway, plays a significant role in glucose metabolism and has been linked to diabetic complications. In this comprehensive study, isoindole-1,3-dione derivatives were synthesized and evaluated for their inhibitory effects on the recombinant human AR enzyme. The compounds’ inhibitory activities were measured both in vitro and through in silico techniques, employing molecular docking and free binding energy calculations and ADME studies. The newly synthesized compounds demonstrated varied inhibitory effects, with ethyl and phenyl substituents at specific positions enhancing inhibitory activity. Notably, compounds with carboxylic acid derivatives exhibited potent inhibitory effects, especially compound 6 with an IC50 value of 1.649 μM. In conclusion, this study provides valuable insights into the inhibitory potential of isoindole-1,3-dione derivatives against AR, suggesting their potential therapeutic application in mitigating diabetic complications. The combination of experimental and computational approaches offers a comprehensive understanding of the compounds’ interaction mechanisms and pharmacokinetic profiles, supporting their further exploration as antidiabetic agents.
- MakaleYalnız künye2024Scopus SJRQ1Mindfulness-based cognitive therapy for adherence of immunosuppressive treatment in liver transplant recipients: A randomized controlled trial
Bulbuloglu, Semra; Gunes, Hüseyin
Objective: The aim of this study was to analyze the effects of mindfulness-based cognitive therapy on the adherence of liver transplant recipients to immunosuppressive therapy with a randomized controlled design. Method: This randomized controlled trial was performed with 120 liver transplant recipients hospitalized at the liver transplant department of a research and practice hospital (n = 120). While we administered no intervention to the patients in the control group (n = 60), we provided Mindfulness-Based Cognitive Therapy to those in the experimental group (n = 60). We used the Mindful Attention Awareness Scale and the Immunosuppressant Therapy Adherence Scale to collect data. We utilized descriptive statistics, paired-samples t-tests, independent-samples t-tests, one-way analysis of variance, and chi-squared tests to analyze the data. Results: After the intervention, the immunosuppressive therapy adherence levels of the experimental group increased significantly (p < 0.01). On the other hand, the control group had significantly higher adherence to immunosuppressive therapy and significantly higher levels of mindfulness in the pretest phase than it did in the posttest phase (p < 0.01). Conclusions: Complete adherence to immunosuppressive therapy is imperative for the prevention of graft rejection in liver transplant recipients. In our study, the experimental group equipped with enhanced mindfulness had higher adherence to immunosuppressive therapy. Therefore, the use of Mindfulness-Based Cognitive Therapy in the promotion of adherence to immunosuppressive therapy is recommended.
AtıfScopus6WoS5OpenAlex7
İncele - MakaleAçık Erişim2024Scopus SJRQ2Cross-cultural adaptation and psychometric evaluation of the Turkish version of the Smombie Scale for Adolescents
Sönmez Sari, Ebru; Temel Mert, Zeynep; Semerci Çakmak, Vahide; Sevgil Atli, Pelin
Background: Smombie has become an important problem especially in terms of adolescent health. The aim of this study was to translate the Smombie Scale for Adolescents (SSA) into Turkish and to examine its psychometric properties. Methods: This study has a methodological design. The study was conducted between March and April 2024. The sample of the study consisted of 430 adolescents. The data were collected by using Personal Information Form and SSA. Content Validity Index, Confirmatory Factor Analysis (CFA), test−retest reliability, Cronbach's α coefficient, item-total score correlation, 27% upper−lower group item analysis and Hotelling T2 test were used in data analysis. Results: The four-factor structure of the scale showed a good fit in CFA (chi-square minimum discrepancy [CMIN] = 187.463, degrees of freedo (DF) = 83, CMIN/DF = 2.259, root mean square error of approximation = 0.054, root mean square residual = 0.033, goodness of fit index = 0.947, adjusted goodness of fit index = 0.923, normed fit index = 0.930, tucker-lewis index = 0.949 and comparative fit index = 0.959). Cronbach's α coefficient of the scale was found to be 0.86. The item-total score correlation of the scale was found between 0.212 and 0.721. The test-retest intraclass correlation coefficient of the scale was found to be 0.876. Conclusions: This study shows that the scale is a reliable tool for assessing adolescents' smombie tendencies. It is thought that the scale will contribute to the protection and development of adolescent health.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2024Scopus SJRQ2Investigation of the effect of green walking and intelligence games on the cognitive skills of individuals between the ages of 50–70 survived COVID-19 disease: A randomized controlled study
Akeren, Zahide; Hintistan, Sevilay
Background: Mild cognitive impairment can be considered as the preclinical stage of Alzheimer's disease. With the addition of COVID-19 disease to the cognitive decline that occurs with aging, it may cause dementia with severe cognitive losses such as Alzheimer's disease in some people. Physical activity and brain-occupying practices can significantly improve the risk factors for cognitive disorders and Alzheimer's disease. Objective: The aim of study was to examine the effect of green walking and intelligence game on the cognitive skills of individuals aged 50–70 years with COVID-19. Methods: The randomized controlled study was completed with 40 individuals, 20 in the experimental and 20 in the control group. Individuals in the experimental group green walking for 30 min three days a week for one month in two groups of 10 people, accompanied by the researcher. In addition, these individuals played intelligence games (brain games-memory thinking and brain exercise) via their smartphones for 15 min every day for a month. Results: The cognitive skills and cognitive dimensions of “attention, concentration, memory, language and orientation” of the individuals in the experimental group were significantly increased compared to the control group individuals (p < 0.05). Conclusions: It was found that green walk and intelligence game practice increased the cognitive skills of individuals aged 50–70 years who had outpatient COVID-19. © The Author(s) 2024. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
AtıfScopus1WoS2OpenAlex2İncele - MakaleAçık Erişim2024Scopus SJRQ3The effect of injectable platelet-rich fibrin in combination with autogenous bone grafts on bone healing in an ovariectomized osteoporotic rat model with critical-sized defects
Durmuşlar, Mustafa C.; Gülşen, Elif A.; Bayburt, Kemal A.; Ballı, Umut; Ocak, Mert; Fırat, Ayşegül; Zırh, Elham B.; Çelik, Hakan H.
OBJECTIVES: To assess the impact of autogenous graft materials, including autogenous bone graft (ABG) and injectable platelet-rich fibrin (I-PRF) clots, on bone defect regeneration in ovariectomized osteoporotic rats. METHODS: Wistar rats (6-8 weeks old) were ovariectomized, and surgery began after 8 weeks. A 5-mm defect was created bilaterally in the parietal bones of 16 rats, which were divided into 4 groups. Group A (blank) had untreated defects; group B had defects filled with 0.1 ml of I-PRF, group C had defects filled with 0.1 ml of ABG, and group D had defects filled with a combination of 0.1 ml each of I-PRF and ABG. Four weeks post-surgery, the rats were euthanized. Bone regeneration was evaluated through histopathologic analysis and microcomputed tomography (micro-CT). RESULTS: In ovariectomized rats treated with ABG or I-PRF, bone regeneration was enhanced, with increased periosteal activity, osteoblast count, and new bone volume, as determined histologically. The ABG+I-PRF group had the highest periosteal vascularity, but the difference compared to the ABG group was not statistically significant (p>0.05). Osteoblast numbers were significantly higher in the ABG+I-PRF group than in the blank group (p<0.05). Micro-CT showed the highest mean new bone volume ratio in the ABG+I-PRF group, followed by the ABG group. CONCLUSION: The combined use of ABG and I-PRF enhances bone formation in osteoporotic rats following ovariectomy. Copyright:
AtıfScopus2OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ2The relationship between self-efficacy and emotional burnout levels of seafarers: the role of individual alienation – the case of Turkey
Battal, Fetullah; Durmuş, İbrahim; Çınar, Ertuğrul
Purpose: The study aims to examine the factors that may affect the burnout levels of ship workers. Design/methodology/approach: The scope of the research consists of seafarers on ships docking at the ports of Zonguldak, Karadeniz Eregli, Eren and Filyos in the Western Black Sea region of Turkey. The sample consists of officers, engineers, dynamic position operators, electricians, boatswains, able seamans, pumpmans and stewards working on ships. In this respect, a random questionnaire was used in the research method and a questionnaire was sent to 400 of these employees, representing the main sample, and 263 of them fully answered the online questionnaire. Findings: As a result of the research, first of all, it is seen that the increase in the self-efficacy of the seafarers decreases their emotional burnout levels. In the second step, the strong self-efficacy of the seafarers reduced the level of individual alienation. In the third step, the increase in the individual alienation of the ship workers also caused an increase in the levels of emotional exhaustion. Originality/value: As a result, it has been seen that there is a partial mediating role of individual alienation in the relationship between the self-efficacy of the seafarers and their emotional exhaustion. In other words, high self-efficacy is not the only reason for the decrease in emotional burnout levels among seafarers. At the same time, self-efficacy has an effect on the individual alienation levels of seafarers.
AtıfScopus1WoS1OpenAlex2İncele - MakaleAçık Erişim2024Scopus SJRQ4Sexual Developmental Characteristics of Intellectually Disabled Adolescents in Türkiye: A Cross-Sectional Analysis
Kirbaş, Zila Özlem; Aktaş, Elif Odabaşi
Purpose: This study aimed to examine the sexual development characteristics of adolescents with intellectual disability in terms of several variables. The data were collected with the Personal Information Form and the Sexual Development Characteristics Scale of Children with Adolescent Mental Disabilities. Method: Independent samples tests, one-way ANOVA tests, and Bonferroni post hoc analyses were conducted to compare the descriptive characteristics of the adolescents and parents with their scale scores. Multiple linear regression analysis was employed to examine the relationships between the dependent and independent variables. Significant differences were identified between certain subdimensions of the scale and the variables. Findings: The sexual arousal subdimension of the scale accounts for 12% of the variance in the dependent variable, the knowledge about physical development subdimension accounts for 10% of the variance in the dependent variable, the sexual satisfaction subdimension accounts for 6% of the variance in the dependent variable, and the sexual self-care subdimension accounts for 11% of the variance in the dependent variable. This difference was explained by the independent variables (R2 adjusted= .12, .10, .06, .11, respectively). Conclusion: In this study, it was found that the sexual development characteristics of adolescents with intellectual disability were affected by the educational status of the mother, the place of residence of the family, the help of the spouse in childcare, the gender of the child, the verbal communication status of the child, the degree of inadequacy of the child, and the ability to meet the personal needs of the child.
AtıfScopus1İncele - MakaleAçık Erişim2024Scopus SJRQ2Effect of kangaroo mother care and white noise on physiological-stress parameters in heel lancing: randomized controlled study
Kirbaş, Zila Özlem; OdabaşI Aktaş, Elif; Bayraktar, Bülent; Özkan, Hava
Background: Newborns are exposed to varying degrees of stressful interventions due to procedures such as heel lancing used in routine metabolic screenings. It is an examination of the effects of white noise and kangaroo care on some physiological parameters and stress markers (cortisol and glucose-regulated protein 78-GRP78) in heel lancing in newborns. Methods: Randomized controlled study was conducted at a gynecology service of a hospital between January and September 2023. 90 babies were divided into three groups: 30 babies in the Kangaroo Care Group (KCG), 30 babies in the White Music Group (WMG), and 30 babies in the Control Group (CG). All babies were randomly divided into groups. Stress parameters were measured by saliva collection method and physiological parameters by saturation device. Results: A statistically significant difference was determined between the total crying time, pulse and saturation values according to the groups (p < 0.001; p = 0.001). A statistically significant difference was determined between the mean values of cortisol and GRP78 measurements according to group and time interaction (p < 0.001). KCG was more effective in reducing total crying time and stabilizing pulse, saturation, salivary cortisol, GRP-78 values compared to WNG and CG. Conclusion: It was concluded that white noise and kangaroo care help reduce newborns’ stress in the case of heel lancing. Practical implications: The practice of kangaroo care and the use of white noise methods may assist healthcare professionals as supportive methods in stress management during invasive procedures. Trial Registration: NCT06278441, registered on 19/02/2024.
AtıfScopus7WoS6OpenAlex8İncele - MakaleAçık Erişim2024Scopus SJRQ1Hypoglycaemic confidence levels and experiences related to the hypoglycaemia of patients with diabetes: A mixed methods study
Sönmez Sari, Ebru; Semerci Çakmak, Vahide; Çetinkaya Özdemir, Serap; Eşsiz Sefer, Betül
Aims: This study had three aims: to determine the hypoglycaemic confidence levels of participants, to identify factors affecting hypoglycaemic confidence levels of participants and to assess experiences related to hypoglycaemia of participants. Design: The explanatory–sequential–mixed method was used in this study. Methods: The quantitative stage included a sample of 177 people, and the qualitative stage included a sample of 18 people. Data of the study were collected between April and June 2023 with the Hypoglycemic Confidence Level Scale, Personal Information Form and Semi-Structured Interview Form. Descriptive statistics, independent samples t-test, one-way ANOVA and multiple linear regression analysis were used for quantitative data analysis. For the qualitative data analysis, content analysis was performed in the MaxQda program. Results: The scale items are scored between 1 and 4, and an increase in the score obtained from the scale indicates an increase in confidence levels. The mean hypoglycaemic confidence level score of the participants was 3. The data obtained in the qualitative stage were grouped under three main themes: Experiences Related to Hypoglycaemia, Reasons for Experiencing Hypoglycaemia and Managing Hypoglycaemia. Conclusion: Identifying hypoglycaemic confidence levels and hypoglycaemia experiences of patients with diabetes can guide health professionals, especially nurses, in promoting person-centred care interventions. Impact: The study discussed the hypoglycaemic confidence levels of diabetic patients and their experiences related to hypoglycaemia. The factors affecting the hypoglycaemic confidence level of the participants were educational status, income status, fear of experiencing hypoglycaemia, ability to self-administer insulin, receiving hypoglycaemia training and frequency of experiencing hypoglycaemia. The results of this study may provide guidance for the development of appropriate prevention and coping strategies for hypoglycaemia. Identifying the experiences of patients with diabetes with hypoglycaemia can guide health professionals, especially nurses, in promoting person-centred care interventions. Reporting Method: The Good Reporting of a Mixed Methods Study (GRAMMS) checklist was used for reporting. Patient or Public Contribution: No patient or public contribution.
AtıfScopus3WoS3OpenAlex4İncele - MakaleYayıncıda açık erişim2024Scopus SJRQ1Do we need a guideline for all: a qualitative study on the experiences of male athletes following anterior cruciate ligament reconstruction
Gökmen, Mehmet Yiğit; Çepikkurt, Fatma; Belibağlı, Mehmet Cenk; Uluöz, Mesut; Özyol, Funda Çoşkun; Bavlı, Özhan; Karıncaoğlu, Ergin; Uluöz, Eren; Türkmen, Mutlu
Background: Considering the low rate of qualitative studies on athletes with anterior cruciate ligament reconstruction (ACLR), aiming to access in-depth data, we thought that the utilization of the qualitative method would allow us to collect the appropriate and sufficient data to yield novel findings and achieve sound conclusions. The study’s aim was to investigate anterior cruciate ligament (ACL) injury experience processes in athletes who had undergone isolated ACLR, reveal the clinically related milestones, and highlight the necessary gaps. Methods: Semi-structured interview techniques, in-depth follow-up questions, and thematic analysis were used to explore the experiences of participants with isolated ACL injuries 1–3 years after surgical treatment. The study was conducted in the Orthopaedics and Traumatology outpatient clinic of the Adana City Training and Research Hospital and included 14 male athletes who had undergone isolated primary ACLR. The study group’s demographic and qualitative data were collected in the first week of September 2023. The member checking process was completed in the third following week. A thematic analysis checklist was used to ensure the reliability of the thematic analysis. The Consolidated Criteria for Reporting of Qualitative Research (COREQ) guidelines were followed. Results: The experiences of 14 patients (22.78 ± 3.76 years, all males) were summarized into four themes that emerged from the data analysis process: ‘The Distinctions in the Participants’ Experiences Regarding the Moment of Injury,’ ‘Gathering Information about the ACL Injury,’ ‘Factors That Facilitate The Treatment Process and Reinforce Positive Experiences,’ and ‘Desperate Plight: Main Points of Patients’ Negative Experiences.’ Based on the main themes, there were 14 subthemes. Conclusions: Our study revealed that varying perceptions of ACL injury presented by the participants, which were caused by all stakeholders, including themselves, the professional environment, family members, social network, and the healthcare staff, showed that the physical and psychological impacts of the injury were observed in different severity levels at each stage of the process. We believe that an extensive guide for athletes with ACL injuries that includes all components of well-being and displays the required details for the sports club/coach, family/companion, and physician.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ1Turkish validity and reliability of the Haptotherapeutic Well-Being Scale
Küçükkaya, Burcu; Işık, Hafsa Kübra; Rathfısch, Gülay
Objectives: Haptotherapy fosters a sense of unity between the body, mind, and emotions. In addition, it contributes to expanding the woman’s perception of her pregnancy and developing a more positive attitude towards pregnancy and childbirth. The study aims to examine the Turkish validity and reliability of the Haptotherapeutic Well-Being Scale, which will be used to evaluate the well-being levels of haptonomy and haptotherapy practices in women. Design: The study was methodological type. Methods: The study conducted between October 20 and December 20, 2023, with 242 women who volunteered to participate by sharing forum pages on social media (Facebook, Instagram) via the web. Data were collected using a personal information form, including sociodemographic and obstetric characteristics and the Haptotherapeutic Well-Being Scale. Results: The Haptotherapeutic Well-Being Scale consists of 14 items and five sub-dimensions. In confirmatory factor analysis, all path coefficients were statistically significant (p < 0.001). The overall Cronbach’s Alpha and sub-dimension values of the scale are above 0.90. There is a positive and very strong correlation between all sub-dimensions of the scale (p < 0.001). Conclusion: The Haptotherapeutic Well-Being Scale was found to be valid and reliable for the Turkish sample. Trials registration: https://clinicaltrials.gov identifier NCT06467188; registered June 14, 2024.
AtıfScopus1WoS1OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ1The Effects of Virtual Reality Intervention Before Total Knee Arthroplasty on Pain, Anxiety, and Vital Signs
Güneş, Hüseyin; Sarıtaş, Serdar
Objective: In this study, the effects of a virtual reality intervention before total knee arthroplasty on pain, anxiety, and vital signs were investigated. Methods: This randomized controlled study with a pretest-posttest design was conducted with 130 patients included in experimental (n = 65) and control (n = 65) groups. Data were collected using a patient information form, the numeric rating scale (NRS), a vital signs form, and the state anxiety inventory. The patients in the experimental group watched a 20-minute video consisting of sea, forest, waterfall, and animal visuals using virtual reality goggles. Vital signs were recorded before and after the intervention. Vital signs were recorded on the same timeline in the control group, without any intervention. Results: The patients in the experimental group displayed lowered anxiety and pain levels and improvements in their vital signs, except for temperature. There were statistically significant differences between the experimental and control groups, except for temperature and diastolic blood pressure (p < .05). Conclusion: The virtual reality intervention reduced pain, anxiety, systolic and diastolic blood pressure, heart rate, and respiratory rate. It is recommended to be implemented before surgery.
AtıfScopus9WoS8OpenAlex11İncele - MakaleAçık Erişim2024Scopus SJRQ2Evaluating STC-1 and STC-2 mRNA expressions in Schizophrenia patients with increased oxidative stress; [Évaluation des expressions d'ARNm de STC-1 et STC-2 chez des patients schizophrènes présentant un stress oxydatif accru]
Karabulut Uzunçakmak, Sevgi; Özcan, Halil; Dirican, Ebubekir; Tavacı Özçelik, Ayşegül
Introduction: Schizophrenia is a chronic psychiatric disorder characterized by cognitive impairment. Oxidative stress is associated with disease progression in patients with schizophrenia. Stanniocalcin (STC)-1 and STC-2 are two proteins commonly expressed in mammals belonging to the stanniocalcin family and they are involved in oxidative stress. The aim of this study is to investigate STC-1 and STC-2 mRNA expressions in schizophrenia patients with altered oxidative stress parameters. Methods: For this purpose, 70 patients with schizophrenia and 40 healthy individuals were recruited for the study. Peripheral blood samples were obtained from all participants. Glutathione (GSH) activities, superoxide dismutase (SOD) activities, and malondialdehyde (MDA) levels were measured. STC-1 and STC-2 expressions were assessed by real-time polymerase chain reactions. Results: SOD activity levels were lower in patients than in healthy individuals (p = 0.0309), while the patients’ MDA levels were higher (p = 0.039). STC-1 and STC-2 expressions were lower in patients than in healthy individuals (p = 0.1049 and p < 0.0001, respectively). Furthermore, these two genes had a positive correlation among the patients (r = 0.435, p = 0.0025). According to area under the curve (AUC) values, STC-2 (AUC = 0.8332, p < 0.0001) had better diagnostic power than STC-1 (AUC = 0.6167, p = 0.1037). Conclusions: The expression of stanniocalcins in schizophrenia was investigated here for the first time. Decreased STC-2 expression in patients with schizophrenia with increased oxidative stress parameters may guide the understanding of the pathophysiological mechanisms caused by oxidative stress, which may be increased in cognitive diseases such as schizophrenia, and it also has the potential to be a prognostic factor that can be used in the diagnosis of schizophrenia.
- MakaleAçık Erişim2024Scopus SJRQ3Occupational Safety and Hidden Risks in a Furniture Factory: A Comprehensive Assessment of Hazards Related to Noise, Lighting, Thermal Comfort, and Dust Exposure
Özdemir, Mustafa; Albayrak, Sirer
This study assessed the occupational health and safety conditions in a furniture manufacturing facility, focusing on key environmental factors such as noise, lighting, thermal comfort, and dust exposure. Noise measurements recorded levels as high as 95.3 dB(A) during CNC machine operations, exceeding legal exposure limits of 87 dB(A), posing significant risks to workers’ hearing health. Lighting assessments showed levels ranging from 134 to 247 lux in production lines, which falls below the recommended threshold of 300 lux for adequate visibility. Thermal comfort was evaluated with temperature readings at 14.2 °C and relative humidity at 43%, revealing marginal comfort conditions that could reduce worker efficiency and satisfaction. Dust exposure measurements indicated respirable dust concentrations reaching 3.69 mg/m³ in the cutting department, which is close to the permissible exposure limit of 5 mg/m³, raising concerns about long-term respiratory health. These findings suggest several measures to improve workplace safety, including enhanced engineering controls, mandatory personal protective equipment (PPE), improved lighting systems, optimised thermal conditions, and advanced ventilation to reduce dust exposure. This comprehensive evaluation provides critical insights for improving furniture factories’ occupational health and safety practices.
AtıfScopus6WoS6OpenAlex3İncele - DüzeltmeAçık Erişim2024Scopus SJRQ1Correction to: Salivary apelin hormone response and dysfunctional attitudes in adolescents in Türkiye: a relational screening model (BMC Psychology, (2024), 12, 1, (64), 10.1186/s40359-024-01551-w)
Kirbaş, Zila Özlem; Bayraktar, Bülent; Aktaş, Elif Odabaşi
Following publication of the original article, it came to the journal’s attention that the order of the citations (following citation of reference 22) was incorrect. The order has since been corrected in the published article.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ3Unveiling the significance of Gremlin-1 as a novel biomarker for enhanced severity prediction in COVID-19 patients
Celik, Muhammet; Tekin, Erdal; Koçak, Mehmet Nuri; Uzunçakmak, Sevgi Karabulut; Bayraktar, Mustafa
Gremlin-1 is associated with lung disease and plays a role in the initiation and progression of pulmonary fibrosis. This suggests that Gremlin-1 may be associated with lung involvement in COVID-19 and poor clinical outcomes and warrants further investigation. This prospective, cross-sectional, single-blind study was the first to investigate Gremlin-1 levels in COVID-19 patients and whether Gremlin-1 levels could be used to predict and guide clinical follow-up in outpatients and inpatients. In this context, serum Gremlin-1 levels were measured and compared in 2 groups of patients who were diagnosed as positive for COVID-19 by RT-PCR and were followed up as outpatients (n = 28) or required hospitalization (n = 30). The median Gremlin-1 values were statistically significantly different between outpatients and intensive care unit patients (0.367 ng/mL [IQR = 0.377], 1.858 ng/mL [IQR = 2.245], respectively) (P < .0001). The area under the ROC curve value to determine the discriminative power of Gremlin-1 was found to be 0.772 (95% CI: 0.672-0.871; P < .0001), and the cutoff value of Gremlin-1 to discriminate between outpatients and hospitalized patients was found to be 1.242 ng/mL with 66.7% sensitivity and 67.2% specificity. Serum Gremlin-1 level is an important biomarker that can be used as a clinical decision-making tool for COVID-19 positive patients.
AtıfScopus2WoS2OpenAlex3İncele - MakaleYalnız künye2024Scopus SJRQ2A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine
Kaya, Alican; Ceylan, Aslı F.; Kavutcu, Mustafa; Santamaria, Abel; Šoltésová Prnová, Marta; Stefek, Milan; Karasu, Çimen
Inhibiting aldose reductase (ALR2, AR) as well as maintaining a concomitant antioxidant (AO) activity via dual-acting agents may be a rational approach to prevent cellular glucotoxicity and at least delay the progression of diabetes mellitus (DM). This study was aimed at evaluating the dual-acting AR inhibitor (ARI) cemtirestat (CMTI) on tissue oxidative stress (OS) and carbonyl stress (CS) biomarkers in rats exposed to fructose alone (F) or fructose plus streptozotocin (D; type-2 diabetic). D and F rats were either untreated or treated daily with low- or high-dose CMTI, ARI drug epalrestat (EPA) or antioxidant stobadine (STB) for 14 weeks. Malondialdehyde (MDA), glutathione S-transferase (GST), nitric oxide synthase (NOS), and catalase (CAT) were increased in the sciatic nerve of F and D. These increases were attenuated by low doses of CMTI and STB in D, but exacerbated by low-dose EPA and high-dose CMTI in F. STB and CMTI and to a lesser extent EPA improved MDA, protein-carbonyl, GST and CAT in the hearts and lungs of F and D. CMTI and STB were more effective than EPA in improving the increased MDA and protein-carbonyl levels in the kidneys of F and especially D. CMTI ameliorated renal GST inhibition in D. In the lungs, hearts, and kidneys of F and D, the GSH to GSSG ratio decreased and caspase-3 activity increased, but partially resolved with treatments. In conclusion, CMTI with ARI/AO activity may be advantageous in overcoming OS, CS, and their undesirable consequences, with low dose efficacy and limited toxicity, compared to ARI or antioxidant alone.
AtıfScopus5WoS6OpenAlex5İncele - MakaleYayıncıda açık erişim2024Scopus SJRQ2The ARK2N (C18ORF25) Genetic Variant Is Associated with Muscle Fiber Size and Strength Athlete Status
Çigirtas, Rukiye; Bulgay, Celal; Kazan, Hasan Hueseyin; Akman, Onur; Sporis, Goran; John, George; Yusupov, Rinat A.; Sultanov, Rinat I.; Zhelankin, Andrey V.; Semenova, Ekaterina A.
Background: Data on the genetic factors contributing to inter-individual variability in muscle fiber size are limited. Recent research has demonstrated that mice lacking the Arkadia (RNF111) N-terminal-like PKA signaling regulator 2N (Ark2n; also known as C18orf25) gene exhibit reduced muscle fiber size, contraction force, and exercise capacity, along with defects in calcium handling within fast-twitch muscle fibers. However, the role of the ARK2N gene in human muscle physiology, and particularly in athletic populations, remains poorly understood. The aim of this study was threefold: (a) to compare ARK2N gene expression between power and endurance athletes; (b) to analyze the relationship between ARK2N gene expression and muscle fiber composition; and (c) to investigate the association between the functional variant of the ARK2N gene, muscle fiber size, and sport-related phenotypes. Results: We found that ARK2N gene expression was significantly higher in power athletes compared to endurance athletes (p = 0.042) and was positively associated with the proportion of oxidative fast-twitch (type IIA) muscle fibers in untrained subjects (p = 0.017, adjusted for age and sex). Additionally, we observed that the ARK2N rs6507691 T allele, which predicts high ARK2N gene expression (p = 3.8 x 10-12), was associated with a greater cross-sectional area of fast-twitch muscle fibers in strength athletes (p = 0.015) and was over-represented in world-class strength athletes (38.6%; OR = 2.2, p = 0.023) and wrestlers (33.8%; OR = 1.8, p = 0.044) compared to controls (22.0%). Conclusions: In conclusion, ARK2N appears to be a gene specific to oxidative fast-twitch myofibers, with its functional variant being associated with muscle fiber size and strength-athlete status.
AtıfScopus8WoS7OpenAlex8İncele - MakaleAçık Erişim2024Scopus SJRQ1The effect of high-intensity plyometric training on anaerobic performance parameters: a pilot study in U17 elite A league
Söyler, Mehmet; Zileli, Raif; Çingöz, Yunus Emre; Kilinçarslan, Gokmen; Kayantas, Idris; Altug, Tolga; Asan, Selim; Sahin, Musa; Gürkan, Alper Cenk
The aim of this study was to examine the effects of high-intensity plyometric training (HIPT) on some parameters in elite soccer players in the U17. Volunteer soccer players were randomly divided into two groups according to their positions: the regular training (RT) group (age: 16.71 +/- 0.47 years; stature: 163.46 +/- 3.31 cm; body weight: 61.04 +/- 1.59 kg) and the HIPT group (age: 16.64 +/- 0.50 years; stature: 165.60 +/- 3.03 cm; body weight: 59.76 +/- 1.92 kg), and each group included five defenders, five midfielders, and four attackers. While the RT group did only routine soccer training, the HIPT group performed high-intensity plyometric training three days a week in addition to routine soccer training. In the study, body weight, stature, sprint (10 m, 30 m, and 40 m), jump (standing long jump, right and left-limb triple hop) and 5-0-5 change of direction speed test measurements of the soccer players were taken. Skewness and Kurtosis values obtained from the pre-test and post-test measurements were calculated to test whether the normality assumption of the study was met. A mixed measure two-way ANOVA test was used to determine the difference between the pre-test and post-test. The significance was set asp < 0.05. The results indicated that 8-week high-intensity plyometric training provided more improvement in measured performance parameters than routine soccer training. As a result, when the data obtained is examined, it can be said that HIPT had better values in sprint, jump, and change of direction parameters, so plyometric training was more beneficial for anaerobic parameters than routine soccer training in children. It is recommended that the trainers make their plans considering these results.
AtıfScopus11WoS11OpenAlex10İncele - MakaleAçık Erişim2023Scopus SJRQ3Reboksetin’in diyabetik sıçanlarda bozulmuş davranış parametreleri üzerindeki yararlı etkileri
Özkay, Ümide Demir; Üçel, Umut İrfan; Yücel, Nazlı Turan; Can, Özgür Devrim; Kandemir, Ümmühan
Amaç: Diyabetik hastalarda duygu-durum hastalıklarının ve kognitif bozukluk insidansının genel popülasyona oranla daha yüksek olduğu bilinmektedir. Bu çalışmada, klinikte antidepresan etkinliği için reçete edilen reboksetin’in sıçanlarda diyabet ile indüklenen davranışsal ve bilişsel değişiklikler üzerine etkinliğinin araştırılması amaçlanmıştır.Gereç ve Yöntem: Sıçanlarda deneysel diyabet modeli 50 mg/kg tek doz streptozotosin enjeksiyonu (i.v.) ile oluşturulnuştur. Reboksetin tedavisine diyabetik komplikasyonların oluşması için 4 hafta beklendikten sonra başlanmıştır. Deney hayvanlarının depresyon ve anksiyete düzeyleri sırasıyla modifiye zorlu yüzme ve yükseltilmiş artı şekilli labirent testleri ile araştırılmış; kognitif performansları ise Morris su tankı ve pasif sakınma testleri ie değerlendirilmiştir. Hayvanlarının motor aktiviteleri de aktivite kafesi ve Rota-rod testleri ile incelenmiştir.Sonuç ve Tartışma: Deneyler sonucunda, diyabetik sıçanların depresyon ve anksiyete düzeylerinin yükseldiği ve bilişsel performanslarının zayıfladığı belirlenmiştir. İki hafta süre ile uygulanan reboksetin tedavisi (8 ve 16 mg/kg) diyabetik sıçanların yüksek depresyon ve anksiyete düzeylerini azaltırken, zayıflamış olan bilişsel performanslarını kayda değer ölçüde güçlendirmiştir. Elde edilen bulgular reboksetin’in diyabete bağlı olarak ortaya çıkan davranışsal ve bilişsel bozuklukların tedavisinde terapötik bir potansiyele sahip olabileceğine işaret etmiştir.
