Yazarlar
- Bayraktar, Bülent(33)
- Dertli, Enes(33)
- Dirican, Ebubekir(20)
- Akeren, Zahide(18)
- İspirli, Hümeyra(18)
- Kizil, Hamit Emre(17)
- Semerci, Vahide(14)
- Bayram, Sinan(13)
- Kul, Murat(13)
- Sönmez Sarı, Ebru(13)
- Agar, Guleray(12)
- Akman, Onur(12)
- Kırbaş, Zila Özlem(12)
- Akeren, İhsan(11)
- Koçak, Lokman(11)
- Makas, Samet(11)
- Can, Zehra(10)
- Uzunçakmak, Sevgi Karabulut(10)
- Yayla, İbrahim Erdoğan(10)
- Çelik, Eyüp(10)
- Bayraktar, B.(9)
- Bulbuloglu, Semra(9)
- Kızıl, Hamit Emre(9)
- Tekce, Emre(9)
- Aydemir, Uğur(8)
- Daştan, Buket(8)
- Hintistan, Sevilay(8)
- Kalyoncuo, Servet(8)
- Sönmez Sari, Ebru(8)
- Türkmen, Mutlu(8)
- Apaydın, Emine(7)
- Arslaner, Ayla(7)
- Beydemir, Şükrü(7)
- Dombak, Kübra(7)
- Kara, Yakup(7)
- Mercan, Emin(7)
- Semerci Çakmak, Vahide(7)
- Can, Özgür Devrim(6)
- Esgin, Özge(6)
- Güneş, Hüseyin(6)
Yayınlar
- MakaleAçık Erişim2024Scopus SJRQ2Eugenol alleviates the negative effects of experimental periodontitis and regulates adipokine hormones in rats
Sevinç Gül, Sema Nur; Özkal Eminoğlu, Didem; Tekçe, Emre; Bayraktar, Bülent; Güven, Leyla; Dilsiz, Alparslan; Yıldırım, Serkan; Sait, Ahmet
A chronic microbial infection that is mediated by the host's immune system is the cause of periodontal disease. As the world's population grows, phytotherapy is a therapeutic strategy that makes use of a renewable resource that can provide less costly medicines. This study aimed to investigate the therapeutic effects of eugenol administration on periodontitis by examining the effects of eugenol at different doses biochemically, histopathologically, and radiologically in rats with experimental periodontitis. Thirty-two Sprague Dawley male rats were divided into four groups: 1. the healthy control group (CG), 2. The experimental periodontitis group (PG), 3. The experimental periodontitis+10 mg/kg eugenol group (EG10), and 4. the experimental periodontitis+20 mg/kg eugenol group (EG20). Alveolar bone loss was measured using micro-CT imaging. The TNF-α, IL-6, leptin, asprosin, and apelin levels were analyzed in the serum samples of rats. Histological and immunohistochemical analyses were performed. The data were analyzed statistically. The serum TNF-α, IL-6, leptin, asprosin, and apelin levels were found to be statistically significantly lower in the eugenol-applied groups (EG10 and EG20) than in the PG (p < 0.05). There was a statistically significant difference in the TNF-α, IL-6, leptin, asprosin, and apelin levels between the EG10 and EG20 (p < 0.05). In the measurements made using micro-CT imaging, alveolar bone loss was found to be at the lowest FR1 level, and in histopathological analysis, the least inflammation was observed in the EG20. It was concluded that the application of 20 mg/kg eugenol in rats with experimental periodontitis was a safe dose, was beneficial in alleviating bone loss, and had a positive effect on the healing process.
AtıfScopus2WoS2OpenAlex2
İncele - MakaleAçık Erişim2024Scopus SJRQ2Antioxidant properties and aldose reductase inhibitory potency of Viscum album L. extracts: experimental and computational insights
Akyüz, Bilal; Şengül, Bülent
This study systematically investigates the antioxidant capacity and inhibitory impact of Viscum album L. plant extracts on the aldose reductase (AR) enzyme through a combined approach of in vitro and in silico methods. Various sections derived from distinct plant parts were examined, revealing potent inhibitory potential. Notably, the methanol extract sourced from the plant’s stem displayed remarkable efficacy with an IC50 value of 0.156 µM. Total phenolic content and antioxidant capacity analyses were conducted, highlighting variations across plant parts and solvent types. Qualitative and quantitative phenolic compound content in the extracts was elucidated by LC-MS/MS analysis, revealing higher levels of quinic acid, fumaric acid, and chlorogenic acid. Molecular docking studies further substantiated the inhibitory roles of key compounds like chlorogenic acid and fumaric acid, elucidating their interactions with specific amino acid residues within the AR enzyme’s active site and shedding light on the underlying mechanisms. Collectively, this study underscores Viscum album L. extracts as promising candidates for aldose reductase modulation. By merging experimental and computational techniques, the study presents a holistic understanding of natural compound interactions, potentially influencing drug development and herbal therapeutics.
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İncele - MakaleAçık Erişim2024Scopus SJRQ1Synthesis of flaxseed gum/melanin-based scaffold: A novel approach for nano-encapsulation of doxorubicin with enhanced anticancer activity
Kumar, Deepak; Pal, Ravi Raj; Das, Neeladri; Roy, Partha; Saraf, Shubhini A.; Bayram, Sinan; Kundu, Patit P.
Doxorubicin is a powerful chemotherapy medicine that is frequently used to treat cancer, but because of its extremely destructive side effects on other healthy cells, its applications have been severely constrained. With the aim of using lower therapeutic doses of doxorubicin while maintaining the same anti-cancerous activity as those of higher doses, the present study designs nano-encapsulation of doxorubicin by acrylamide grafted melanin as core and acrylic acid grafted flax seed gum as shell (DOX@AAM-g-ML/AA-g-FSG-NPs) for studies in-vivo and in-vitro anticancer activity. For biological studies, the cytotoxicity of DOX@AAM-g-ML/AA-g-FSG-NPs was examined on a cancerous human cell line (HCT-15) and it was observed that DOX@AAM-g-ML/AA-g-FSG-NPs exhibited very high toxicity towards HCT-15. In-vivo investigation in colon cancer-inflicted rat model also showed that DOX@AAM-g-ML/AA-g-FSG-NPs showed better anticancer activity against cancerous cells as compared to free doxorubicin. The drug release behavior of DOX@GML-GFS-NPs was studied at several pH and maximum drug release (95 %) was recorded at pH -7.2, and kinetic data of drug release was follows the Higuchi (R2 = 0.9706) kinetic model. Our study is focussed on reducing the side effects of doxorubicin by its nano-encapsulation in acrylamide grafted melanin as core and acrylic acid grafted flax seed gum that will also enhance its efficiency.
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İncele - MakaleAçık Erişim2024Scopus SJRQ1Phytochemical profile, enzyme inhibition, antioxidant, and antibacterial activity of Rosa pimpinellifolia L.: A comprehensive study to investigate the bioactivity of different parts (whole fruit, pulp, and seed part) of the fruit
Findik, Bahar Tuba; Yildiz, Hilal; Akdeniz, Mehmet; Yener, Ismail; Yilmaz, Mustafa Abdullah; Cakir, Ozlem; Ertas, Abdulselam
The pharmaceutical and nutraceutical potentials of whole fruit, pulp and seeds of Rosa pimpinellifolia L. were evaluated. Forty-two phenolic compounds and two triterpenoids were identified in extracts by LC-MS/MS and GC–MS, respectively. The most prominent compounds were ellagic acid, catechin, epicatechin, tannic acid, quercetin, oleanolic acid, and ursolic acid. The highest enzyme inhibitory activities of the extracts (94.83%) were obtained against angiotensin-converting enzyme and were almost equal to those of the commercial standard (lisinopril, 98.99%). Whole fruit and pulp extracts (IC50:2.47 and 1.52 μg DW/mL) exhibited higher antioxidant capacity than the standards (α-tocopherol, IC50:9.89 μg DW/mL). The highest antibacterial activity was obtained against Bacillus cereus (MIC: 256 μg/mL) for the whole fruit extract. Correlation analyses were conducted to find the correlation between individual phenolics and enzyme inhibitory activities. The results showed the remarkable future of not only the edible part but also the seeds of black rose hips in phytochemical and functional aspects.
AtıfScopus15WoS14OpenAlex17İncele - MakaleAçık Erişim2024Scopus SJRQ2Interleukin-27 as a novel player in alleviating hepatic steatosis: Mechanistic insights from an in vitro analysis
Cho, Wonjun; Oh, Heeseung; Abd El-Aty, A.M.; Özten, Ömer; Jeong, Ji Hoon; Jung, Tae Woo
Interleukin-27 (IL-27) is a recently discovered cytokine that has been implicated in inflammatory and metabolic conditions, such as atherosclerosis and insulin resistance. However, the mechanisms by which IL-27 attenuates hepatic lipid accumulation in hyperlipidemic conditions and counteracts endoplasmic reticulum (ER) stress, a known risk factor for impaired hepatic lipid metabolism, have not been elucidated. This in vitro study was designed to examine the effect of IL-27 on hepatic lipid metabolism. The study included the evaluation of lipogenesis-associated proteins and ER stress markers by Western blotting, the determination of hepatic lipid accumulation by Oil Red O staining, and the examination of autophagosome formation by MDC staining. The results showed that IL-27 treatment reduced lipogenic lipid deposition and the expression of ER stress markers in cultured hepatocytes exposed to palmitate. Moreover, treatment with IL-27 suppressed CD36 expression and enhanced fatty acid oxidation in palmitate-treated hepatocytes. The effects of IL-27 on hyperlipidemic hepatocytes were attenuated when adenosine monophosphate-activated protein kinase (AMPK) or 3-methyladenine (3 MA) were inhibited by small interfering RNA (siRNA). These results suggest that IL-27 attenuates hepatic ER stress and fatty acid uptake and stimulates fatty acid oxidation via AMPK/autophagy signaling, thereby alleviating hepatic steatosis. In conclusion, this study identified IL-27 as a promising therapeutic target for nonalcoholic fatty liver disease (NAFLD).
AtıfScopus6WoS6OpenAlex6İncele - MakaleYalnız künye2024Scopus SJRQ1Objective Parameters in Attention Deficit Hyperactivity Disorder: Eye and Head Movements
Yıldırım Demirdöğen, Esen; Akıncı, Mehmet Akif; Bozkurt, Abdullah; Turan, Bahadır; Esin, İbrahim Selçuk; Donbaloğlu, Mehmet Ali; Bingöl, İsa; Tümüklü Özyer, Gülşah; Kılıç, Uğur; Dursun, Onur Burak
Objective: We aimed to evaluate eye and head movements, which are objective parameters in ADHD. Method: While the children were watching the course video task, which included the relevant (teacher and smart board) and irrelevant (any regions outside the relevant area) areas of interest, their eye movements were evaluated through eye tracking, and video recordings were made simultaneous. Head position estimation was made using through video recordings. The proportion of total fixation duration on areas of interest (PFDAOI) and saccade count, amplitude, velocity for eye movements, number of total head movements and angular change of head movement in x-y-z axes for head movements were compared. Results: Children with ADHD had lower PFDAOI on the relevant area, and had more saccade and head movements The angular change of head movement in the x-axis was higher in the ADHD group. Conclusion: In the assessment of ADHD, the eye and head movements may be particulary useful.
AtıfScopus4WoS4OpenAlex4İncele - Derleme MakaleAçık Erişim2024Scopus SJRQ3Psychological Aspects of Behavioral Disorders in Management
Durmuş, Ibrahim
In today's organizations, working environments direct the work activities of all employees. The psychological aspects of behavioral disorders that employees may exhibit in organizational management constitute the main problem of the research. With the help of the Web of Science database, research on the psychological aspects of behavioral disorders in management were examined on a global scale. The bibliometric analysis method was applied to the obtained data using R and R Studio software. Research on the psychological aspects of conduct disorder in management; was conducted from 1994-2023 and 229 sources. The annual growth rate of research is 2.42%. The number of research conducted on the subject reached maximum levels in 2020 and the number of citations in 2002. Contributing the most to the subject; author, Davis, journal, AIDS Care-Psychological and Socio-Medical Aspect of AIDS/HIV, country, USA, keywords therapy and depression, and the University of Washington. Some of the keywords that authors focused on the most in their research; depression, anxiety, treatment, chronic pain, HIV, Covid-19, psychotherapy, quality of life, managing, stress, psychological, and adolescents. The strongest relationship among the concepts related to the subject was between depression and anxiety. In recent years, the idea of depression has been emphasized the most. In terms of the psychological aspect of behavioral disorder in management, the strongest relationships were between the concepts of "depression, anxiety, HIV, psychotherapy, pain, sleep, cognitive behavioral therapy, mental health, and therapy". The conclusion reached by using the literature was that individuals should be healthy both biologically and psychologically in their organizational activities.
- MakaleAçık Erişim2024Scopus SJRQ1Evaluation of nurses’ attitudes and behaviors regarding narcotic drug safety and addiction: a descriptive cross-sectional study
Kaya, Ayten; Kirbaş, Zila Özlem; Medin, Suhule Tepe
Background: By evaluating nurses’ attitudes and behaviors regarding narcotic drug safety and addiction, effective strategies need to be developed for combating addiction in healthcare institutions. This study, aimed at providing an insight into patient and staff safety issues through the formulation of health policies, aimed to evaluate nurses’ attitudes and behaviors regarding narcotic drug safety and addiction. Methods: The study was conducted in a descriptive cross-sectional design. It was carried out with 191 nurses in a public hospital between March 2023 and August 2023. Data were collected through face-to-face interviews, gathering socio-demographic information and utilizing the Addictive Substance Attitude Scale. The data were analyzed using independent sample t-tests, one-way ANOVA tests, and regression analysis (P <.001 and p <.05). Results: The average age of the participants was determined to be 36.58 ± 8.40. It was reported by 85.3% of nurses that narcotic drug follow-ups in their units were conducted according to procedures. In the study, it was found that 63.9% of nurses did not know the procedure to be followed towards a healthcare professional identified as a narcotic substance addict. The total mean score of the Addictive Substance Attitude Scale of nurses participating in the study was 74.27 ± 14.70. A significant difference was found between the total scores of the scale and the level of education of nurses, the follow-up status of the drugs in the unit where they work, their status of receiving narcotic drug addiction training, and their routine use of the half-dose drug disposal form (p <.05). Conclusions: The findings of this study underscore the importance of evaluating nurses’ attitudes and behaviors regarding narcotic drug safety and addiction. These results indicate the need for nursing administrators, particularly in terms of patient and staff safety, to adopt more effective policies and strategies.
AtıfScopus1WoS1OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ3Fear of missing out mediated the relationship between social appearance anxiety and phubbing in Turkish adults
Batmaz, Hasan; Çelik, Eyüp; Koçak, Lokman; Nur Tufan, Beyza; Makas, Samet; Yıldırım, Murat
The existing body of research lacks investigations into the potential links between fear of missing out (FOMO), social appearance anxiety, and phubbing. For the first time, this study examined the mediating role of FOMO in the relationship between phubbing and social appearance anxiety. Participants included 341 Turkish adults (Mage = 28.25, SD = 8.02) and completed the measures of FOMO, social appearance anxiety, and phubbing. Results showed that social appearance anxiety was positively related to FOMO and phubbing. Also, FOMO was positively associated with phubbing. The results of the mediation analysis indicated that FOMO partially mediated the association of social appearance anxiety with phubbing. These results suggest that social appearance anxiety exacerbates the FOMO, which in turn leads to an increased level of phubbing. These findings have significant implications for both research and practice.
AtıfScopus8OpenAlex5İncele - MakaleAçık Erişim2024Scopus SJRQ3Investigation of Microbiological, Physiological and Histopathological Changes in Polymicrobial Infection in Old Rats
Ülker, U.; Kızıl, S.; Bayraktar, B.; Alçığır, M.E.; Kul, O.; Kaya, H.; Ürüşan, H.; Aydemir, Ş.; Kotan, G.C.; Önel, A.U.
Background: The aim of this study is to examine the microbiological, clinical, physiological and pathological findings of natural polymicrobial infection developing in a wistar rat colony under long-term observation. Methods: In this study, 70 male Wistar albino rats, 3 years old, raised by conventional methods and housed in a cage environment were used. Thirteen rats with clinical symptoms such as torticollis and rotation were sacrificed for microbiological and histopathological examination after 14 days. For microbiological examination, the rapid diagnostic kit BBL Crystal system was used to identify bacterial agents in tissue and stool samples and the traditional culture method was used for isolation. Result: As a result of microbiological analysis, the rarely isolated Staphylococcus capitis (S. capitis) was isolated. Different Staphylococcus spp. It has been determined that the species can cause suppurative meningoencephalitis as well as septicemia in the brains of experimental animals., it is thought that polymicrobial infection will be useful for the identification of bacterial agents and infection prevention and treatment strategies.
- MakaleYalnız künye2024Scopus SJRQ2The effect of loneliness on fear of aging: Mediated by social support
Akeren, Zahide; Akeren, Ihsan
The study aimed to examine the relationships between loneliness, perceived support and fear of old age, to determine how they differ according to some socio-demographic variables and of loneliness to reveal the mediating role of perceived social support in the effect on fear of old age. In the descriptive cross-sectional study conducted between November 2023 and January 2024, the Loneliness Orientation Scale (LOS), Multidimensional Perceived Social Support Scale (MSPSS) and Fear of Old Age Scale (FOS) were used. Correlational analysis was used in the analysis of data collected from 611 participants aged 18–65 with two-stage sampling, T-test and ANOVA were used in the comparison of means, and the Hayes’ PROCESS macro was used to determine the mediating role of perceived social support. Women, singles, young people, those with low education and income fear old age more. There is a positive correlation between loneliness and fear of aging, and a negative correlation between these two and perceived social support. As a result, perceived social support is a partial mediator in the effect of loneliness on fear of old age and it should be considered as an effective source in reducing fear of old age.
AtıfScopus1WoS1OpenAlex2İncele - MakaleYayıncıda açık erişim2024Scopus SJRQ1Investigation of Post-Transplant Mental Well-Being in Liver Transplant Recipients with Hepatic Encephalopathy
Saritaş, Serdar; Tarlaci, Sultan; Bulbuloglu, Semra; Guneş, Hüseyin
Objective: In this study, we aimed to examine the healing trend of hepatic encephalopathy after transplantation surgery in patients with liver failure. Method: We conducted this descriptive and cross-sectional study with the participation of liver transplant recipients. A personal information form, the West Haven Criteria (WHC), the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS), and the Richmond Agitation Sedation Scale (RASS) were used for data collection. The data were analyzed using Chi-squared tests, ANOVA, and paired-samples t-tests. Results: As time progressed after liver transplantation, hepatic encephalopathy stages regressed (p < 0.01). We found that liver transplant recipients with end-stage hepatic encephalopathy were mostly within the first 6 months after transplantation, while patients with first-stage hepatic encephalopathy had received liver transplants more than 2 years ago (p < 0.01). Conclusions: The results of our study revealed that hepatic encephalopathy stages regressed after transplantation, but there was no complete recovery. This highlights the need to develop new treatment strategies other than liver transplantation for the treatment of hepatic encephalopathy.
AtıfScopus5WoS5OpenAlex6İncele - MakaleYalnız künye2024Scopus SJRQ2Do the natural and herbal remedies used for fighting against COVID-19 pose a risk for surgical patients?
Özkan, Meral; Güneş, Hüseyin
Introduction: To determine what natural and herbal remedies were used in the fight against COVID-19 and analyze the potential of these products to create a risk for surgical patients. Methods: The study was conducted with a descriptive and cross-sectional research design. The data were collected between September and October 2021. In the study, convenience sampling, which is a non-probability sampling method, was used. An online questionnaire was applied to the participants on social media platforms. In the data collection process, 1 488 individuals were reached. Results: The most frequently used herbal remedies by the participants were garlic (62.8%), ginger (53.4%), linden (42.3%), turmeric (37.9%), and oregano (35.6%). The most frequently used natural remedies were lemon (65.4%), honey (53.8%), yogurt (47.2%), traditional soups (33.5%), and vinegar (33.1%). The most frequently used supplements of vitamins were vitamin D (42.4%) vitamin C (41.1%), vitamin B12 (22.4%), vitamin E (8.7%), and fish oil/Omega-3 fatty acids (7.5%). Among the participants who reported that they used natural and herbal remedies (n = 710), only 6.9% were determined to have undergone a surgery in this period. Furthermore, 89.8% of these individuals who presented to the hospital for a surgery had not been asked whether they used natural or herbal remedies by healthcare professionals. Conclusion: The intake of garlic and vitamin E supplements according to the American Society of Anesthesiologists and the intake of garlic, ginger, turmeric/curcumin, and vitamin E supplements according to the Society for Perioperative Assessment and Quality Improvement Consensus Statement should be stopped before a surgery.
AtıfScopus2WoS2OpenAlex2İncele - MakaleYayıncıda açık erişim2024Scopus SJRQ1Can Enzymatic Modified Pectin in Mediterranean Fruits Be Therapeutic Against Stomach Cancer?
Üstün, Selime; Kizil, Hamit Emre; Dertli, Enes
The aim of this study was to evaluate the cytotoxic effects of enzymatically modified pectin products derived from grapefruit, jujube, and kumquat on the MKN-45 gastric cancer cell line in vitro. FTIR analysis revealed that the spectra of the pectins produced were comparable to those of commercial pectin and included the characteristic peaks identified in the literature. The galacturonic acid content was measured as 612 mg/g in grapefruit pectin, 544 mg/g in jujube pectin, and 704 mg/g in kumquat pectin. DSC analysis indicated that all pectin samples and their modifications exhibited one endothermic peak and one exothermic peak. Cytotoxicity assessments revealed that the enzymatically modified grapefruit pectin demonstrated significant cytotoxic effects across all tested concentrations, with 0.075 mg/mL being the most effective. For kumquat pectin, all tested concentrations showed cytotoxic properties, with 0.3, 0.15, and 0.075 mg/mL being the most effective. In the case of jujube pectin, cytotoxic effects were observed at all concentrations except for 1.2 mg/mL.
AtıfScopus3WoS3OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ1Validity and reliability of the Turkish version of the transition of primiparas becoming mothers scale
Kirbaş, Zila Özlem; Odabaşi Aktaş, Elif; Özkan, Hava
Background: The transition to motherhood is an important life event in a woman’s life and represents an important developmental process that brings physical, psychological and social changes to gain a new role. However, research on the transition to motherhood in Turkish society is scarce. There is a need for a comprehensive, practical and reliable tool to evaluate the transition to motherhood in primiparous mothers. This study evaluated the reliability and validity of the Turkish version of the Transition of Primiparous Becoming Mothers Scale (TMP-S) to evaluate the transition process of primiparous mothers to motherhood. Methods: This methodological research was carried out in obstetrics and gynecology outpatient clinics, pediatric outpatient clinics, and family health centers of a hospital in Türkiye. The sample consisted of primiparous mothers of 0 to 6- month-old babies who visited clinics and family health centers for routine postnatal examinations (n = 305). After evaluating the language equivalence and content validity of the scale, test-retest reliability, internal consistency and construct validity were examined. Factor analysis, Pearson’s correlation, retest reliability, and Cronbach’s alpha were employed to evaluate structural validity and reliability. Results: The final TPM-S had two dimensions with 25 items. Exploratory factor analysis revealed a two-factor solution, which accounted for 59.276% of the variance. Confirmatory factor analysis showed that the model fit of the two-factor model also reached a satisfactory model ft after modification. The comparative fit index was 0.894, the Tucker‒Lewis index was 0.882, and the root mean square error of approximation was 0.079. The content validity index of the scale ranged from 0.56 ~ 0.77. The Cronbach’s alpha coefficient was 0.93 for the total scale, and the test–retest reliability was 0.96. Conclusions: It is a valid and reliable tool for evaluating the transition to motherhood among primiparous mothers of 0 to 6 month-old babies in Türkiye. Turkish researchers and healthcare professionals can routinely apply this measurement tool to primiparous mothers in the first six months after birth to evaluate their transition to motherhood.
AtıfScopus1İncele - MakaleYayıncıda açık erişim2024Scopus SJRQ1The effect of bed exercises following major abdominal surgery on early ambulation, mobilization, pain and anxiety: A randomized-controlled trial
Simsek Yaban, Zuleyha; Bulbuloglu, Semra; Kapikiran, Gurkan; Gunes, Huseyin; Kula Sahin, Sennur; Saritas, Serdar
This randomized-controlled trial aimed to investigate the effect of bed exercises on postoperative anxiety, pain, early ambulation and mobilization. This study was conducted with a randomized-controlled trial design and in the general surgical clinic of a research and training hospital. A total of 120 patients (60 in the experimental group and 60 in the control group) scheduled for major abdominal surgery took part in the study. The data were collected using a patient information form, the Anxiety Specific to Surgery Questionnaire and the Visual Analog Scale through face-to-face interviews. The patients in the experimental group performed 15-min bed exercises on the day of their operation, as well as on the postoperative first and second days, and the control group underwent only the routinely performed procedures in the clinic. The data were analysed using descriptive statistics, analysis of variance and t-tests. The sample of our study included major abdominal surgery patients. Ambulation was achieved at a mean time of 4 h earlier in the experimental group. On the postoperative first and second days, the patients in the experimental group had mean mobilization durations that were approximately 2 h longer compared with the patients in the control group. Moreover, the postoperative pain and anxiety levels of the patients in the experimental group were significantly lower than those of the patients in the control group (p < 0.05). We recommend that bed exercises be performed to lower anxiety and pain severity, achieve early ambulation and increase the duration of mobilization among patients following major abdominal surgery.
AtıfScopus7WoS8OpenAlex9İncele - MakaleYalnız künye2024Scopus SJRQ1The effect of nurse-led motivational interviewing based on the trans-theoretical model on promoting physical activity in healthy older adults: A randomized controlled trial
Sönmez Sari, Ebru; Kitiş, Yeter
Aim: The aim of this study was to evaluate the effect of motivational interviewing based on the trans-theoretical model promoting physical activity in older adults. Methods: A randomized controlled trial study was conducted with 117 older adults (intervention group: 58, and control group: 59) between April and November 2019. The data were collected via a questionnaire, trans-theoretical model scales, the Physical Activity Scale for the Elderly, the Katz Activities of Daily Living scale and a pedometer. The 24-week intervention consisted of regular motivational interviewing. The control group received usual care at the family health centre. Results: Following the intervention, the Intervention Group showed significant improvements Exercise Processes of Change Scale, Exercise Self-Efficacy Scale and Perceived Benefits of the Decisional Balance Scale for Exercise. There was a significant difference between the groups in terms of stages of change. In the Intervention Group, 81.5% were in the contemplation stage in the pre-test, while in the post-test, 70.4% had transitioned to the action stage. In contrast, in the control group, 62.5% were in the contemplation stage initially, but in the post-test, only 9.3% had reached the action stage. The mean number of step counts increased significantly in favour of the Intervention Group, as did the Physical Activity Scale for the Elderly total score. Conclusion: The trial indicated that after the trans-theoretical model-based motivational interviewing, the stages of change among the older adults improved, as did their exercise behaviours. It is recommended that the trans-theoretical model and motivational interviewing be used by nurses to improve healthy lifestyle stage behaviours in older adults.
AtıfScopus14WoS12OpenAlex12İncele - MakaleAçık Erişim2024Scopus SJRQ3InvestIgatIon of cytotoxIcIty and antIbacterIal effect of boron-contaInIng nano-hydroxyapatIte
Aydın, Numan; Karaoğlanoğlu, Serpil; Süloğlu, Aysun Kılıç; İdil, Neslihan; Demir, Merve; Karakaş, İbrahim Hakkı
Introduction: Different regenerative materials are used to protect and stimulate pulp tissue. Objectives: This in vitro study aimed to examine the cytotoxicity of different doses of boron-containing nano-hydroxyapatite (B-nHAp) and its antibacterial effect. Material and methods: B-nHAp was synthesized with microwave-assisted chemical precipitation method at different rates, such as 1%, 5%, and 10%. The extracts were prepared in separate tubes: 1%, 5%, 10% B-nHAp, and nHAp 50 mg/ml. Cytotoxicity test was performed on L929 mouse fibroblasts for 24 and 72 hours. Antibacterial analysis was performed with Streptococcus mutans bacteria using micro-dilution method. Cell viability values were evaluated with two-way analysis of variance (ANOVA) test (p < 0.05). Results: B-nHAp was successfully synthesized in XRD and SEM analyses. Nano-hydroxyapatite showed more cell viability than control group at 24 and 72 hours. All B-nHAp extracts demonstrated less cell viability at the end of 24 hrs. than control group. However, 1% B-nHAp cell viability decreased more in the B-nHAp group compared with the control group, while 5% and 10% B-nHAp showed high cell viability after 72 hours of incubation. B-nHAp demonstrated less antibacterial effect on Streptococcus mutans compared with nHAp. Conclusions: According to the results, the addition of boron to nano-hydroxyapatite does not make a significant contribution to increase the regenerative and antibacterial properties of the material.
AtıfScopus4OpenAlex5İncele - MakaleAçık Erişim2024Scopus SJRQ3The relationship between parental awareness of sexual abuse and children's skills to say «no»; [Relación entre la conciencia de madres y padres sobre el abuso sexual y las habilidades de los niños para decir «no»]
Kirbaş, Zila Özlem; Şahin, Emel
Introduction: Child sexual abuse is a global and multidimensional social problem and causes devastating and permanent psychological, emotional, cognitive, behavioural, physical, sexual and interpersonal sequelae. This study examines the relationship between the ability to say «no» and parental awareness of sexual abuse in 4th grade primary school students. Methods: The study was conducted between April 2022 and June 2022 in primary schools in the central district of a province in north-eastern Turkey. The sample consisted of 310 students enrolled in 4th grade and their parents. We collected the data through a personal information form, the ability to say «no» scale for children and the sexual abuse awareness scale for parents. Results: There was a weak positive correlation between the mean maternal scores of sexual abuse awareness and the mean scores of refusal and resistance in children (P ˂ .05), as well as a weak positive correlation between the mean paternal scores of sexual abuse awareness and the mean scores of refusal and resistance in children (P ˂ .05). Conclusion: As mothers’ and fathers’ awareness of sexual abuse myths and of teachings and actions to combat sexual abuse increased, the refusal of children also increased. Also, as fathers’ awareness of the signs of sexual abuse increased, children's refusal increased.
AtıfScopus3WoS2OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ1Virtual Reality Technology in Nursing Education: A Qualitative Study
Avşar, Gülçin; Çelik, Şeymanur; Doğan, Sevgi; Çiftçi, Bahar
Virtual reality (VR) technology plays a significant role in nursing education by enhancing the quality of training by applying knowledge, decision-making, intervention completion and feedback. This study aims to examine nursing students' experiences and perceptions regarding the ventrogluteal injection training provided through VR technology. Conducted between May and June 2022, this qualitative descriptive phenomenology study took place at a state university in Turkey, involving 70 students who participated in Ventrogluteal Drug Administration training using VR glasses. The sample included 12 students selected via the Criterion Sampling Method. Data collection tools comprised the ‘Descriptive Information Form’ and a ‘Semi-Structured Questionnaire’. Qualitative data were analysed using the Content Analysis Method, while quantitative data were assessed through descriptive statistical methods (frequency, percentage, mean). The study identified 13 codes, four sub-themes and two main themes from the students' evaluations. The first main theme, ‘Weaknesses of Virtual Simulation’, included two sub-themes: ‘Due to its Nature’ and ‘Due to its Technique’, resulting in five codes. The second main theme, ‘Strengths of Virtual Simulation’, was divided into two sub-themes: ‘Permanence, Integrity, and Applicability’ and ‘Emotions towards Virtual Simulation’, with eight codes identified. The findings indicate that students view VR technology positively in their education. However, they also highlighted specific issues related to the simulation's technique and inherent nature.
AtıfScopus5WoS4OpenAlex6İncele
