Yazarlar
- Bayraktar, Bülent(33)
- Dertli, Enes(33)
- Dirican, Ebubekir(20)
- Akeren, Zahide(18)
- İspirli, Hümeyra(18)
- Kizil, Hamit Emre(17)
- Semerci, Vahide(14)
- Bayram, Sinan(13)
- Kul, Murat(13)
- Sönmez Sarı, Ebru(13)
- Agar, Guleray(12)
- Akman, Onur(12)
- Kırbaş, Zila Özlem(12)
- Akeren, İhsan(11)
- Koçak, Lokman(11)
- Makas, Samet(11)
- Can, Zehra(10)
- Uzunçakmak, Sevgi Karabulut(10)
- Yayla, İbrahim Erdoğan(10)
- Çelik, Eyüp(10)
- Bayraktar, B.(9)
- Bulbuloglu, Semra(9)
- Kızıl, Hamit Emre(9)
- Tekce, Emre(9)
- Aydemir, Uğur(8)
- Daştan, Buket(8)
- Hintistan, Sevilay(8)
- Kalyoncuo, Servet(8)
- Sönmez Sari, Ebru(8)
- Türkmen, Mutlu(8)
- Apaydın, Emine(7)
- Arslaner, Ayla(7)
- Beydemir, Şükrü(7)
- Dombak, Kübra(7)
- Kara, Yakup(7)
- Mercan, Emin(7)
- Semerci Çakmak, Vahide(7)
- Can, Özgür Devrim(6)
- Esgin, Özge(6)
- Güneş, Hüseyin(6)
Yayınlar
- MakaleAçık Erişim2026COVID-19 Sonrası Tedarik Zinciri Gecikmelerine Dair Ampirik Kanıtlar: APEC Ekonomileri Örneği
Okur, Fatih
Bu çalışma, 2015–2023 döneminde APEC ülkelerinde tedarik zinciri gecikmelerinin temel belirleyicilerini analiz etmektedir. Panel veri analizi yoluyla COVID-19 pandemisi, ekonomik gelişmişlik düzeyi ve bölgesel ticaret anlaşmalarının etkileri incelenmiştir. Ayrıca, modelde sanayi üretimi, dış ticaret hacmi, ticaret açıklığı, enflasyon oranı ve doğrudan yabancı yatırımlar gibi kontrol değişkenlerinin de tedarik zinciri gecikmeleri üzerindeki etkileri analiz edilmiştir. Sabit etkiler modeline dayalı analiz sonuçları, ihracat ve ithalat hacmi, sanayi üretimi ve ticaret açıklığının gecikmeleri artırdığını; ekonomik büyüme oranı ile doğrudan yabancı yatırımların ise gecikmeleri azalttığını göstermektedir. Ayrıca, enflasyon oranı ve pandemi dönemi gecikmeler üzerinde anlamlı ve olumsuz etkiler yaratmıştır. Alt grup analizleri, bu ilişkilerin dönemsel ve ülke türüne göre farklılaştığını ortaya koymaktadır. Elde edilen bulgular, tedarik zinciri performansını artırmak isteyen politika yapıcılar için önemli yol göstericidir. Bu bağlamda lojistik altyapının güçlendirilmesi, fiyat istikrarının korunması ve esnek tedarik stratejilerinin geliştirilmesi önerilmektedir.
- MakaleAçık Erişim2026Hareketsiz bireylerde kettlebell egzersizlerinin kas mimarisi ve gerilme-kısalma döngüsü fonksiyonu üzerıne etkileri
Kul, Murat; Hazar, Kürşat; Öktem, Tuncay; Berk, Hazar Emre
Bu çalışma, sekiz haftalık kettlebell ve fitness egzersizlerinin vastus lateralis (VL) kas mimarisi ve dikey sıçrama performansı üzerindeki etkilerini incelemiştir. Yaşları 18-45 arasında değişen, sağlıklı 20 erkek katılımcı (kettlebell grubu: n=10; fitness grubu: n=10) çalışmaya dahil edilmiştir. Ön test değerlendirmeleri VL ultrason ölçümleri ve dikey sıçrama testlerini içermiştir. Kettlebell grubu balistik kettlebell egzersizleri gerçekleştirirken, fitness grubu geleneksel direnç antrenmanı uygulamıştır. Grup içi değişimleri analiz etmek için eşleştirilmiş örneklem t-testi, gruplar arası farklılıkları değerlendirmek için bağımsız örneklem t-testi kullanılmıştır. Anlamlılık düzeyi p<0,05 olarak kabul edilmiştir. Kettlebell egzersizleri squat sıçrama (SS) ve aktif sıçrama (AS) performansını anlamlı derecede artırmıştır. VL kas kalınlığı ve dinamik pennasyon açısındaki değişimler istatistiksel olarak anlamlı bulunmamakla birlikte artış eğilimi göstermiştir. Buna karşılık fitness egzersizleri VL kas kalınlığını, pennasyon açısını (PA) ve squat sıçrama (SS) performansını anlamlı derecede artırmış, ancak aktif sıçrama (AS) üzerinde anlamlı bir etki göstermemiştir. Her iki grupta da fasikül uzunluğunda (FU) anlamlı bir değişiklik gözlenmemiştir. Bu bulgular, kettlebell egzersizlerinin gerilme-kısalma döngüsü aracılığıyla patlayıcı performansı geliştirdiğini, fitness egzersizlerinin ise kas hipertrofisi ve kas mimarisi adaptasyonlarını daha etkili şekilde desteklediğini göstermektedir. Her iki egzersiz türü farklı hedeflere hizmet etmektedir; bu nedenle bireysel antrenman hedeflerine bağlı olarak birlikte uygulanmaları hem performans hem de kas yapısı açısından faydalı olabilir.
- MakaleAçık Erişim2026Phytochemical profile, antioxidant potential, and cytotoxic effect of the ethanol extract of Micromeria fruticosa
Çakır, Özlem; Topcu, Kübra Cinar; Anlar, Pinar
In this study, the ethanol extract of dried Micromeria fruticosa (L.) Druce, commercially sourced from the Tortum Valley (Erzurum Province), was comprehensively analysed to evaluate its bioactive potential. Considering that geographical origin and botanical differences significantly influence phytochemical composition and biological activity, the use of locally sourced commercial samples provides valuable data for plant standardisation and comparative studies. The total antioxidant activity of the extract was determined as 8.84±0.10, 4.96 ±0.05, 34.64 ±0.69, and 18.27 ±0.11 mg TE/g dry weight by DPPH, FRAP, CUPRAC, and ABTS assays, respectively. The total phenolic content was 26.25 mg GAE/g dry weight, and LC-MS/MS analysis revealed a high quinic acid content (93.395 mg/g). ICP-MS analysis showed high levels of essential minerals (Na, Mg, K, Ca, Fe, and Al), while toxic elements such as Cd, Te, and Tl were below the limit of detection, and Pb and Ba were present at very low concentrations. Additionally, the extract significantly reduced A549 lung cancer cell viability in a dose-dependent manner. Overall, Tortum Valley–derived M. fruticosa represents a promising natural bioactive source, and this study highlights the impact of local botanical and environmental variations on the biological activity of the same plant species.
- MakaleAçık Erişim2026Assessment of The Relationship Between Telomere Length and Physiological Parameters in Cattle Infected with Bovine Leukosis Virus
Ince, Omer Baris; Bayraktar, Bülent; Tezcan, Erdem; Korkmaz, Serol; Sait, Ahmet
The study aims to investigate the relationship between relative telomere lengths and various physiological parameters in cattle infected with bovine leukosis virus, as well as to identify the risk factors associated with cow-level bovine leukosis virus infection in dairy cattle in Türkiye. Three variables—age, parity, and body condition score—were used for risk assessment. Antibodies specific to bovine leukosis virus were detected using an enzyme-linked immunosorbent assay, and relative telomere lengths were measured by polymerase chain reaction. The highest seropositivity rate (39.13%) was observed in cattle with a body condition score of 3–3.5 and aged between 2–8 years. relative telomere length was found to be positively correlated with seropositivity, advanced age, and parity, while a negative correlation was observed between seropositivity and body condition score. Relative telomere lengths in bovine leukosis virus-infected cattle were significantly shorter (P < 0.05) than those in non-infected cattle. Among body condition score groups, the shortest relative telomere lengths were found in bovine leukosis virus-infected cattle with body condition score ≤ 2.5 and in non-infected cattle with body condition score 3–3.5. Regarding age groups, the shortest relative telomere lengths were observed in bovine leukosis virus-infected cattle older than 8 years (P < 0.05), as well as in non-infected cattle of the same age group (P < 0.05). In conclusion, relative telomere lengths in bovine leukosis virus-infected cattle were found to be significantly shorter than in non-infected cattle (P < 0.05). The shortest relative telomere lengths were recorded in both bovine leukosis virus-infected and non-infected cattle over 8 years of age (P < 0.05). Finally, the association between bovine leukosis virus infection and relative telomere lengths, along with other factors such as age, parity, and body condition score, is considered potentially useful for disease control and prevention programs.
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İncele - MakaleAçık Erişim2026A moderated mediation model of AI acceptance in healthcare: Perceived AI usage competence, AI trust, and AI anxiety
Kılınç, Mehmet
This study examined whether perceived AI usage competence is associated with AI acceptance in healthcare and whether this association is mediated by AI trust and moderated by AI anxiety. A cross-sectional, correlational survey design was used. Data were collected online from 422 adults in Türkiye who had used healthcare services within the previous six months. Perceived AI usage competence was modeled as the independent variable, AI trust as the mediating variable, AI acceptance in healthcare as the outcome variable, and AI anxiety as the moderating variable. Descriptive statistics, reliability analysis, confirmatory factor analysis, Pearson correlation analysis, and Hayes PROCESS Macro Model 8 were used to analyze the data. The findings indicated that perceived AI usage competence was positively associated with AI trust and AI acceptance in healthcare, and AI trust was positively associated with AI acceptance. The trust-mediated indirect association between perceived AI usage competence and AI acceptance was statistically significant. AI anxiety moderated both the competence–trust association and the direct competence–acceptance association, with weaker associations observed at higher levels of AI anxiety. Overall, the findings suggest that AI acceptance in healthcare is related not only to perceived technical competence but also to psychosocial factors such as trust and anxiety.
- MakaleAçık Erişim2026Improvement of machine learning-based diabetes diagnosis via resampling techniques
Yapici, Irem Senyer; Arslan, Rukiye Uzun; Engin, Mustafa Alptekin
The objective of this study is to enhance the accuracy of diabetes diagnosis through the utilisation of machine learning techniques and resampling methods. The imbalanced nature of diabetes datasets presents a significant challenge for traditional classification algorithms, which often struggle to accurately predict results. In order to enhance the efficacy of the model, a comparative analysis was conducted to assess the performance of a range of over-sampling and under-sampling techniques, including SMOTE, ADASYN, Borderline SMOTE, SVM SMOTE, Random Under Sampler, Near Miss, One Sided Selection, Neighbourhood Cleaning Rule, Edited Nearest Neighbours, Instance Hardness Threshold, AllKNN and Tomek Links. The aforementioned techniques were then applied to the Decision Tree, Random Forest, K-Nearest Neighbours, AdaBoost, Extra Tree Classifier, and machine learning classifiers, and their performance was evaluated using the accuracy, recall, precision, F-Score, and AUC-ROC performance metrics. The SVMSMOTE resampling technique was identified as the most successful method, achieving 99.06% accuracy when used in combination with the decision tree classifier. The findings demonstrate that the incorporation of resampling techniques markedly enhances diagnostic proficiency and yields more dependable forecasts. This research makes a significant contribution to the field of medical informatics, providing a robust framework for diabetes diagnosis and offering valuable insights into the application of machine learning healthcare.
- MakaleYalnız künye2026Scopus SJRQ3Adult's food label awareness: scale development and validation
Açikgöz, Inci; Köktürk, Seda Nur; Yardimci, Hulya
PurposeThis study aimed to develop and validate the Food Label Awareness Scale (FLAS) to comprehensively assess adults' food label reading habits and expectations.Design/methodology/approachThe FLAS was developed based on a literature review and expert input. Initial item generation was followed by expert evaluations for content and face validity. Data were collected through structured face-to-face interviews using the preliminary version of the FLAS and a sociodemographic questionnaire. A total of 300 adults aged 20-65 years participated. Food label awareness was assessed based on the three subdimensions: (1) product packaging and ingredients, (2) nutrition and health and (3) product brand. In addition, participants' age, gender and education level were recorded. Cronbach's alpha assessed internal consistency. Reliability was supported by comparing the highest and lowest 27% of total scores. Associations between demographics and subdimension scores were tested using appropriate statistical methods.FindingsThe finalized 18-item FLAS demonstrated a three-factor structure with acceptable model fit and internal consistency. Older adults had higher awareness of packaging and ingredients. Lower education was associated with greater reliance on product brand.Research limitations/implicationsA primary limitation is the geographically restricted sample, which may limit the generalizability of the findings.Originality/valueThis study is original in developing a valid and reliable scale specifically measuring adults' awareness of food label reading - an area less explored in the literature, which mostly emphasizes general nutrition knowledge or label reading frequency.
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İncele - MakaleYalnız künye2026Scopus SJRQ2The Mediating Role of Parental Self-Efficacy in the Relationship Between Parenting Stress and Coparenting
Turhan, Fatma Seher; Yayla, Ibrahim Erdogan; Sahranç, Umit; Makas, Samet; Yildirim, Murat
Parenting stress is a critical factor influencing family dynamics, often undermining the quality of coparenting. Exploring the mechanisms through which parenting stress impacts coparenting and the potential mediating role of parental self-efficacy is essential for developing effective family-based interventions. This study aims to examine the mediating role of parental self-efficacy in the relationship between parenting stress and coparenting. The sample consisted of 240 parents (79.6% female) aged 25-58 (M = 36.5). Participants completed the Parenting Stress scale, the Berkeley Parenting Self-Efficacy Scale, and the Coparenting Scale. Parenting stress showed a significant negative association with both coparenting quality and parenting self-efficacy. Furthermore, parenting self-efficacy was found to mediate the association between parenting stress and coparenting. These results highlight the important role of parents' self-efficacy in influencing how stress influences coparenting dynamics. Strengthening parents' confidence in their parenting abilities may help buffer the harmful effects of stress and foster more cooperative, supportive coparenting practices.
- MakaleYalnız künye2026Scopus SJRQ1Morin counteracts KBrO3-induced hepatotoxicity by reprogramming the HOTAIR/MEG3-miR-125b-5p/miR-214-5p axis and suppressing STAT1-associated RIPK3/MLKL necroptotic signaling
Özer, Muhammed Rasit; Özdemir, Selcuk; Küçükler, Sefa; Özkaraca, Mustafa; Kizil, Hamit Emre; Akaras, Nurhan; Mutlu, Huseyin; Kandemir, Fatih Mehmet
Potassium bromate (KBrO3; PB), an oxidative contaminant in ozonated water and bakery products, induces multi-mechanistic hepatotoxicity. Its epigenetic, necroptotic, and metabolic injury dimensions remain poorly characterized. Morin (MOR), a dietary flavonoid with established antioxidant and anti-inflammatory properties, has not previously been evaluated against PB-induced subacute hepatotoxicity. To characterize MOR's hepatoprotective mechanisms against PB-induced liver injury, focusing on the HOTAIR/MEG3-miRNA epigenetic axis, STAT1-associated RIPK3/MLKL necroptotic signaling, and Glut2/HPGD-AKT/mTOR metabolic signaling. Male Sprague-Dawley rats (n = 28) were assigned to Control, MOR (100 mg/kg), PB (62 mg/kg), and PB + MOR groups for 14 days. Outcomes included hepatobiliary biochemistry, oxidative stress markers, inflammatory mediators (ELISA), lncRNA/miRNA/mRNA profiling (RT-qPCR), immunohistochemistry (RIPK3, MLKL), double immunofluorescence (Glut2/AKT1; HPGD/mTOR), histopathology, and PCA. PB produced marked redox imbalance (up arrow MDA; down arrow SOD, CAT, GPx), NF-kappa B/NLRP3-associated inflammatory mediator elevation, epigenetic disruption (up arrow HOTAIR, down arrow MEG3; up arrow miR-125b-5p/down arrow BCL2L2; down arrow miR-214-5p/up arrow SMAD4), upregulation of STAT1-associated necroptosis-related transcripts and proteins (up arrow RIPK1/RIPK3/MLKL), and metabolic dysfunction (down arrow Glut2, down arrow HPGD; up arrow AKT1/mTOR). MOR restored redox balance, suppressed inflammation, and reprogrammed the miRNA axis while normalizing MLKL (transcript and immunohistochemistry) and AKT1 and partially attenuating RIPK3, mTOR, and STAT1. MOR confers multi-targeted hepatoprotection by restoring redox and metabolic homeostasis, attenuating NF-kappa B/NLRP3-associated inflammation, reprogramming HOTAIR/MEG3-miRNA epigenetics, and attenuating STAT1-associated RIPK3/MLKL signaling, supporting its potential as a dietary hepatoprotective candidate. PB is associated with engagement of the hepatic STAT1/RIPK3/MLKL axis and disrupts the HOTAIR/MEG3-miRNA network-both previously undocumented for this toxicant. MOR partially restores miR-214-5p/miR-466 expression while suppressing their downstream effector SMAD4, consistent with attenuation of pro-fibrotic signaling. Future work should employ multi-dose designs, in vitro mechanistic dissection, sex-stratified analyses, and clinical pharmacokinetic profiling to advance MOR toward translational application.
- MakaleAçık Erişim2026Scopus SJRQ1Self-Regulation and Mathematics Anxiety: The Conditional Mediating Role of Mathematical Language Self-Efficacy and Implications for Inclusive Education
Öztürk, Mesut; Ada Yildiz, Kübra; Charitaki, Garyfalia
In this quantitative study, we investigated the conditional mediating role of students’ mathematical language self-efficacy in the relationship between self-regulation and mathematics anxiety. The study employed a relational research design and included survey data from 706 middle school students attending public schools in Turkey. Findings indicated that both self-regulation and perceived self-efficacy in mathematical language use were significantly associated with mathematics anxiety. Moreover, the effect of self-regulation on mathematics anxiety was significantly mediated by students’ perceptions of their ability to understand and use mathematical language self-efficacy. The indirect effect was negative while the direct effect was positive, indicating a suppression (competitive mediation) effect, whereby self-regulation exerts both anxiety-reducing and potentially anxiety-inducing influences through different pathways. Conditional mediation analysis further revealed that this mediating effect varied as a function of students’ perceived academic support, with the indirect effect being non-significant for students who did not receive support. Measurement invariance across gender and grade level was examined to ensure that the constructs were measured equivalently across groups. These findings highlight the importance of fostering both self-regulation skills and mathematical language proficiency, particularly in contexts where students may lack sufficient support. These findings provide a theoretically grounded and practically relevant framework for understanding mathematics anxiety within inclusive mathematics education contexts.
- MakaleAçık Erişim2026Scopus SJRQ1A natural nephroprotective adjuvant for cancer chemotherapy: Rosmarinic acid disrupts IL-17 A-Ferroptosis coupling in Ifosfamide-induced renal injury
Süzen Celbek, Büşra; Şimşek, Hasan; Akaras, Nurhan; Kandemir, Özge; Kızıl, Hamit Emre; Mutlu, Hüseyin; Kandemir, Fatih Mehmet
Rosmarinic acid (RA) is a natural polyphenol with established pleiotropic protective effects. Ifosfamide (IFA) is a potent antineoplastic agent whose clinical utility is severely limited by dose-dependent nephrotoxicity, primarily mediated by its metabolite, chloroacetaldehyde (CAA). This study aimed to investigate whether RA protects against IFA-induced nephrotoxicity and to elucidate the underlying molecular mechanisms. Male Wistar albino rats (n = 7 per group) were allocated into four groups: Control, RA-only (50 mg/kg, p.o., 2 days), IFA-only (a single 500 mg/kg, i.p. dose), and IFA + RA. Serum biochemical markers (urea, creatinine), renal oxidative stress parameters (MDA, GSH, SOD, CAT, GPx), gene expression levels (NF-κB, TNF-α, IL-1β, IL-17 A, ACT1, TRAF6, Caspase-3, Bax, Bcl-2, PTGS2, GPX4, TfR1), and histopathological/immunohistochemical analyses (KIM-1, Nephrin, Caspase-3) were performed 24 h post-administration. IFA induced severe renal dysfunction, marked oxidative stress, and extensive histopathological damage. Mechanistically, IFA initiated a pathogenic cascade activating intrinsic apoptosis and ferroptosis, driven by a self-sustaining IL-17 A-TRAF6-NF-κB inflammatory loop. RA co-treatment (50 mg/kg) significantly reversed all functional, biochemical, and histological damage by strategically breaking this crosstalk, restoring redox homeostasis, and simultaneously restraining both cell death programs. In conclusion, RA protects against IFA nephrotoxicity by targeting the critical inflammation-ferroptosis coupling, positioning it as a highly promising adjuvant candidate for clinical use to mitigate IFA-induced renal injury.
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İncele - DüzeltmeAçık Erişim2026Scopus SJRQ1Correction: From screens to minds: the mediating role of psychological well-being between digital reading and AI anxiety (Frontiers in Psychology, (2025), 16, (1727759), 10.3389/fpsyg.2025.1727759)
Özbilen, Uǧur; Banaz, Emrullah; Şahin, Tuǧrul Gökmen
Positive Psychology Affiliation 3 “Department of Social Sciences and Turkish Language Education, Inonu University, Malatya, Türkiye” was erroneously given as “Department of Social Sciences and Turkish Language Education, Ataturk University, Erzurum, Türkiye”. The original version of this article has been updated.
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2026Scopus SJRQ2Effect of Virtual Reality Glasses on Mild Cognitive Impairment in Older Adults: A Randomized Controlled Trial
Daştan, Buket; Ünal, Hediye
PURPOSE: The current randomized controlled trial evaluated the effect of a virtual reality (VR) glasses intervention on mild cognitive impairment (MCI) in older adults. METHOD: This study was conducted with 24 participants (12 in the intervention group and 12 in the control group) admitted to a neurology outpatient clinic. Participants completed a descriptive information form, the Mini-Mental State Examination, and Montreal Cognitive Assessment. The intervention group watched VR videos 3 days per week for 4 weeks, whereas the control group received no intervention. RESULTS: Participants in the VR intervention group showed improvement in MCI, whereas no significant change was observed in the control group. CONCLUSION: VR interventions may serve as effective tools to enhance cognitive functions in older adults with MCI. Expanding the intervention content and tailoring applications to address specific symptoms may yield more comprehensive results.
- MakaleAçık Erişim2026Scopus SJRQ3Neurobiological and psychological effects of reciting the Quran from the Mushaf
Okur, Süheyb; Bayraktar, Bülent
Background: This study aims to examine the acute neurobiological effects of reciting the Quran from the Mushaf on salivary BDNF, Apelin, and Cortisol levels and their relationship with emotional state. Methods: The study employed a randomized pre-test post-test control group design conducted in Türkiye. The sample consisted of 100 healthy theology students (50 females, 50 males) aged 18–25, proficient in reciting the Quran in accordance with Tajweed rules. Participants were randomly assigned to either the experimental group (reciting the first nine verses of Surah Al-Imran, n = 50) or the control group (standardized passive resting, n = 50). Salivary BDNF, apelin, and cortisol levels were measured using the ELISA technique before and after the intervention. Emotional states were assessed using the Mood Scale and the Psychological Well-being Scale. Results: The experimental group exhibited a statistically significant increase in mean salivary BDNF and apelin levels and a significant decrease in cortisol levels following recitation compared to the passive control group (p < 0.05). In terms of gender, no statistically significant differences were observed in biomarker responses (p >.05). Correlation analysis revealed a significant “biological reciprocity,” where cortisol showed a negative correlation with apelin (r = -0.436, p < 0.001) and BDNF, while correlating positively with negative emotions. Conclusions: Reciting the Quran aloud acts as a rapid psychophysiological intervention that downregulates the HPA axis (reduced cortisol) and upregulates neurotrophic factors (increased BDNF and apelin). These findings suggest that structured recitation functions as a restorative neuroplasticity practice, promoting biological stress resilience associated with psychological well-being.
AtıfScopus2WoS3OpenAlex2İncele - MakaleYayıncıda açık erişim2026Scopus SJRQ2Dual antidepressant-like and antinociceptive effects of Hypericum olympicum extract in mice: preclinical behavioral evidence
Saltan, Nagehan; Üçel, Umut İrfan; Göger, Fatih; Özkay, Ümide Demir; Can, Özgür Devrim
Hypericum Tourn. ex L. species exhibit well-documented neuropsychopharmacological activities, yet the central effects of Hypericum olympicum L. remain unknown. Given the frequent comorbidity of depressive symptoms and pain, this study aimed to characterize, for the first time, the antidepressant-like and antinociceptive profile of H. olympicum in mice. A methanolic extract of the aerial parts (HoE) was prepared, and its major phenolic constituents were identified by LC-MS/MS. At behaviorally active doses, HoE (2.5 and 5 mg/kg, i.p.) did not impair motor coordination in the Rota-rod test, in contrast to diazepam (2 mg/kg, p.o.), indicating the absence of neuromotor confounding effects. In both the tail suspension test (TST) and the modified forced swim test (MFST), HoE significantly reduced immobility, with effects comparable to those of fluoxetine (30 mg/kg, p.o.). In the MFST, increased swimming behavior without changes in climbing suggested a predominantly serotonergic component. HoE also produced marked antinociceptive effects in multiple nociceptive models. It increased response latencies in the hot-plate, tail-immersion, and tail-clip tests, reflecting activity in supraspinal and spinal thermal and mechanical nociceptive processing. In addition, HoE significantly reduced acetic acid-induced writhing, indicating visceral antinociceptive activity. Morphine (10 mg/kg, i.p.) served as the positive control in pain assays. LC-MS/MS analysis indicated the presence of major phenolic constituents, including hyperoside, myricetin derivatives, caffeoylquinic acid derivatives, a luteolin/kaempferol-type glucoside, and a biflavone of the biapigenin/amentoflavone type. These findings suggest that HoE possesses dual antidepressant-like and antinociceptive properties and support its further evaluation for disorders at the affect–pain interface.
- MakaleYalnız künye2026Scopus SJRQ2Hot injection synthesis of metal-doped Ag2S nanocrystals: A novel multifunctional approach for cancer therapy, antibacterial strategies, and antioxidant defense
ULUSU, Funda; OZEL, Sultan Suleyman; Sarilmaz, Adem; ULUSU, Yakup
This pioneering study presents the synthesis and comprehensive evaluation of bare and metal-doped Ag₂S nanocrystals (NCs) as multifunctional agents with potential applications in antibacterial, antioxidant, and anticancer therapies. The incorporation of manganese, nickel, cobalt, and zinc into Ag₂S NCs resulted in a notable enhancement of their bioactivity, representing a novel approach in nanomaterial design. The antibacterial assessments revealed that Mn:Ag₂S NCs were the most potent candidate, exhibiting exceptional activity against S. aureus and E. coli, with the lowest MIC values recorded at 1.28 mg/mL and 1.08 mg/mL, respectively. The antioxidant studies demonstrated that the Mn:Ag₂S NCs exhibited remarkable free radical scavenging and ferric reducing capacities, with the lowest IC50 values (22.69 µg/mL for DPPH and 61.31 µg/mL for FRAP) underscoring their potential to mitigate oxidative stress. Importantly, cytotoxicity assays revealed that Ni:Ag₂S and Mn:Ag₂S nanocrystals selectively inhibited the proliferation of human colon cancer cells (HT-29), achieving IC50 values of 61.51 µg/mL and 90.12 µg/mL, respectively. Furthermore, these NCs demonstrate reduced toxicity towards mouse fibroblast cells (L929). This selective cytotoxicity indicates the potential of these agents in targeted cancer therapies, thereby reducing damage to healthy tissues. To the best of our knowledge, this is the first study to systematically explore the synergistic effects of metal doping on the multifunctional properties of Ag₂S NCs. These findings provide a robust basis for further in vivo studies and offer new avenues for the development of safe and effective nanomaterials in biomedical applications, particularly as antimicrobial, antioxidant, and anticancer agents.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ1Ecological and nutritional analysis of artificial intelligence-based sustainable dietary models
Köktürk, Seda Nur; Yardımcı, Hülya
Growing concerns over environmental sustainability and health have increased the demand for sustainable diets. Advances in artificial intelligence (AI) offer new opportunities for diet planning. Evaluating the nutritional adequacy and environmental impact of AI-generated sustainable diets is essential. This study aimed to compare the nutritional quality and ecological footprints of sustainable diets created by four popular AI tools (Gemini, Copilot, ChatGPT, and Grok). Each AI tool generated a sustainable diet plan for a healthy adult woman. Diets were evaluated for energy, nutrient content, antioxidant capacity, glycemic index, protein quality, fatty acid profiles, Healthy Eating Index-2015 scores, and ecological footprints. All diets showed low ecological footprints but did not meet energy targets (1800 kcal/day). Gemini had the most sustainable composition. Vitamin B12 was consistently below recommended levels in diets from Gemini, Copilot, and ChatGPT. All diets had adequate carbohydrate, protein, fat quality, and overall diet quality. Carbon footprint associated with protein, energy from protein, cholesterol, pyridoxine, folate, and vitamin C. Water footprint was linked to multiple nutrients, and fruits, meat, poultry, and fish; vegetable intake correlated with carbon footprint. AI-assisted diets have potential for sustainability but nutritional completeness concerns remain, especially for vulnerable groups. Further studies comparing AI and dietitian plans are needed to assess long-term effects.
AtıfScopus1WoS1OpenAlex3İncele - MakaleYalnız künye2026Scopus SJRQ3Acute muscle responses according to training level in traditional Turkish archery: an examination of swelling and damage
Kul, Murat; Hazar, Emre Berk
This study aimed to compare acute muscle swelling and echogenicity responses induced by repeated arrow shooting in experienced and amateur traditional Turkish archers, and to examine the influence of training level using ultrasonography. Twenty-four male athletes (12 experienced, 12 amateur) performed 105 arrow shots. Pre- and post-measurements of upper-extremity muscle thickness (MT) and echogenicity were collected. Data were analyzed using repeated-measures analysis of variance (ANOVA) and paired t-tests. Both groups showed significant increases in MT, particularly in experienced archers. Echogenicity increased in several muscles, notably the supraspinatus, brachialis, pronator teres, and brachioradialis. The lack of strong correlation between MT and echogenicity suggests that these parameters reflect distinct acute muscular responses. In conclusion, training level influences acute muscular adaptations to shooting, and certain muscles may require targeted protection to prevent overuse injuries. This study provides the first ultrasonographic evaluation of these responses in traditional Turkish archery.
- MakaleYalnız künye2026Scopus SJRQ1Associations between preschool children’s perspective-taking skills and their perceived abilities and behavioral intentions toward peers with special educational needs
Ari-Arat, Ceren; Tutkun, Cansu
The aim of this study was to examine the associations between preschool children’s perceived capabilities, perspective-taking skills, and behavioral intentions toward peers with special educational needs. The sample consisted of 193 preschool children aged 4 to 6 years, selected through convenience sampling from early childhood education centres in Bayburt, Türkiye. A quantitative cross-sectional design was employed. Data were collected using the Child Information Form, the Perceived Capabilities Scale, the Behavioral Intentions Scale, and the Child Perspective-Taking Test. Data collection was conducted in one-on-one sessions over two meetings per child, with an average duration of 18 min. Small but statistically significant positive associations were observed between children’s perceived capabilities and their behavioral intentions across the three peer conditions (r =.283-0.289, p <.01). Small associations were also observed between selected perspective-taking components and behavioral intentions in the bivariate analyses; however, none of the perspective-taking components remained significantly associated with behavioral intentions after the other variables were taken into account. Across the three regression models, perceived capabilities were the only variable that remained significantly associated with behavioral intentions (β = 0.268-0.289, p <.001). The regression models explained a modest proportion of the variance in behavioral intentions (R² = 0.093-0.106; adjusted R² = 0.074-0.087). Exploratory group comparisons indicated selective differences in perspective-taking according to reported experience with peers with SEN; however, these findings should be interpreted cautiously because experience was measured dichotomously and the direct-experience groups were highly unequal. Girls reported slightly higher behavioral intentions toward peers with physical disabilities than boys (t = 2.318, p =.022), whereas no significant age-related differences were observed.
- MakaleYayıncıda açık erişim2026Scopus SJRQ2Metabolic, adipokine (irisin, spexin, visfatin), and ER stress (GRP78) responses in multiparous Brown Swiss cows: a multivariate approach across physiological stages and body condition scores
Kotan, Gökşad Cemil; Aydemir, Şeyma; Bayraktar, Bülent
This study investigated the responses of novel adipokines (irisin, spexin, visfatin), an endoplasmic reticulum (ER) stress marker (GRP78), and traditional metabolic parameters (non-esterified fatty acids (NEFAs), beta-hydroxybutyrate (BHBA), urea, albumin, globulin, total cholesterol) in 360 healthy Brown Swiss dairy cattle. The animals were categorized into 18 subgroups based on pregnancy stages (early, mid, dry), lactation stages (early, mid, late), and body condition scores (BCSs). Serum analyses were performed using ELISA and spectrophotometric methods. Interactions between physiological stages and BCS were highly significant for all measured parameters (p<0.001). Results showed that mean serum levels of spexin (ranging from 14.02 to 36.04 pg mL−1) and irisin increased as pregnancy and lactation progressed. Visfatin levels exhibited a significant increase specifically during the gestation period, peaking during the dry period (24.09 ng mL−1), and maintained a significant increasing trend as lactation progressed toward the late stage (Tables 2, 4). Conversely, GRP78 (peaking at 0.46 ng mL−1), NEFA (peaking at 0.52 mmol L−1), and urea levels peaked during the dry period and early lactation, subsequently decreasing as metabolic stability was achieved. Notably, during the dry period, stress markers rose despite declining albumin and globulin levels (p<0.05). These data indicate that the dry period and early lactation are the most critical phases for metabolic and cellular stress, characterized by lower spexin and elevated GRP78 and NEFA concentrations. The later rise in irisin and visfatin, while BHBA remained within physiological limits, confirms successful metabolic adaptation (p<0.001). In conclusion, the integrated evaluation of these novel biomarkers is anticipated to provide significant contributions to protective strategies and metabolic management in dairy cattle.
