Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Battal, Fetullah(10)
- Ayata, Ümit(8)
- Dertli, Enes(8)
- Kul, Murat(8)
- Kan, Muhammed Enes(7)
- Kaya, Yunus(7)
- Öztekin, Sebahat(7)
- Akeren, Zahide(6)
- Aydemir, Uğur(6)
- Bayraktar, Bülent(6)
- Korkmaz, Huseyin(6)
- Peker, Hüseyin(6)
- Aksakalli, Ayhan(5)
- Apak, Ömer Ceyhun(5)
- Banaz, Emrullah(5)
- Can, Zehra(5)
- Esmer, Yusuf(5)
- Hasar, Ugur Cem(5)
- Kutlu, Naciye(5)
- Sönmez Sari, Ebru(5)
- Sönmez Sarı, Ebru(5)
- Ulay, Göksel(5)
- Çolak, Murat(5)
- Ünlü, Hami(5)
- İspirli, Hümeyra(5)
- Aksan, Nurcan Demircan(4)
- Bayraktar, B.(4)
- Degirmenci, Yavuz(4)
- Doğan, Zeki(4)
- Ecem Bayram, Nesrin(4)
- Elmalı, Kübra(4)
- Iliev, Teodor(4)
- Kadakal, Mahir(4)
- Kalyoncuo, Servet(4)
- Semerci Çakmak, Vahide(4)
- Yayla, İbrahim Erdoğan(4)
- Zozik, Adalet(4)
- Öktem, Tuncay(4)
- Şenay, Volkan(4)
- Abdioglu, Murat(3)
Yayınlar
- MakaleYayıncıda açık erişim2025Scopus SJRQ2Primula longipes subsp. bayburtensis Sefali, Yapar & Demir (Primulaceae): A new taxon from north-eastern Anatolia, Türkiye
Sefalı, Abdurrahman; Yapar, Yakup; Demir, İbrahim; Yurtvermez, Bayram; Keser, Ali Murat
The new taxon, Primula longipes subsp. bayburtensis Sefali, Yapar & Demir, subsp. nov. (Primulaceae) is described and illustrated from Bayburt Province, Türkiye. It is morphologically assigned to Primula sect. Crystallophlomis based on its long scapes, lanceolate and denticulate leaf with long petiole and hairless habit, fruits longer than calyx and covered by farina on the scape. This new taxon is similar to Primula longipes and P. nivalis subsp. turkestanica; it can also be easily distinguished by its calyx divided ratio, thurm flowers (unwidened corolla tube shape and length) and capsules (length) futures.
- MakaleAçık Erişim2025Scopus SJRQ2SOME NEW INEQUALITIES FOR DIFFERENTIABLE ARITHMETIC-HARMONICALLY CONVEX FUNCTIONS
Kadakal, Mahir; Agarwal, Praveen; İŞcan, İMdat
In this study, by using an integral identity together with both the Hölder and the power-mean inequalities for integrals we establish several new inequalities for differentiable arithmetic-harmonically-convex function. Also, we give some applications for special means.
AtıfOpenAlex1
İncele - MakaleYalnız künye2025Scopus SJRQ2Death Literacy Index Short Form: Cultural Adaptation and Psychometric Evaluation of the Turkish Version
Semerci Çakmak, Vahide; Sönmez Sarı, Ebru; Seven, Ahmet
The aim of this study was to adapt the short form of Death Literacy Index (DLI-9) into Turkish and to examine its psychometric properties. This study has a methodological cross-sectional design. The study was conducted with a sample of 400 adults across Türkiye during October-November. Content Validity Index, Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), Convergent and Discriminant Validity Analyses, test-retest reliability, Cronbach’s α-coefficient, item-total-score correlation, 27% upper-lower-group item analysis and Hotelling-T2test were used in data analysis. In the EFA analysis, the scale consisted of 2 factors. The original two-factor structure of the scale was confirmed by CFA. CFA model fit values were found as CMIN/DF = 2.078, RMSEA = 0.074, RMR = 0.077, SRMR = 0.0455, CFI = 0.960, NFI = 0.927, TLI = 0.945, GFI = 0.946, and AGFI = 0.906. The total Cronbach’s α reliability coefficient of the DLI-9 was found to be 0.84. This study indicates that scale is a reliable tool for evaluating death literacy in the Turkish population.
AtıfOpenAlex1
İncele - MakaleAçık Erişim2025Scopus SJRQ2Social Media Addiction and Cognitive Behavioral Physical Activity Among Adolescent Girls: A Cross-Sectional Study
Sönmez Sari, Ebru; Terzi, Handan; Şahin, Didem
Objective: To measure a multivariate analysis of social media addiction and cognitive-behavioral physical activity associated with several sociodemographic characteristics in adolescent girls. Design and Methods: A cross-sectional study. The sample consisted of adolescent girls studying in a vocational high-school in the Middle-Black-Sea region in Türkiye (n = 333). A questionnaire, Social Media Addiction Scale-for-Adolescents (SMAS-A), and Cognitive-Behavioral Physical Activity Questionnaire (CBPAQ) were used to collect the data. Results: The mean age was 15.35 (SD = 1.15), and 29.4% were the ninth-class students. Of the adolescent girls, 85.9% were social-media users, 59.8% used the internet 2-hours-or-more/daily, 67.9% declared themselves as moderately-active. The mean scores of the SMAS-A and the CBPAQ were 3.40 (SD = 1.61) and 21.03 (SD = 7.64), respectively. There was a significantly-negative correlation between cognitive-behavioral physical activity and social-media addiction levels. The One-Way MANOVA results showed significant differences in the academic level, family income, mother education, and physical activity measurement application usage affected to cognitive-behavioral physical activity. Social media usage habit affected to the social media addiction level. Conclusions: Daily internet usage time and self-declared physical activity level were the mutually affected factors. School nurses should act to improve healthy social media usage habits to promote well-being and encourage the positive attitudes towards regular physical activity in this population.
AtıfScopus13WoS14İncele - MakaleAçık Erişim2025Scopus SJRQ2Some new Simpson type integral inequalities for (s, P)-functions
Kadakal, M.; İşcan, İ.; Kadakal, H.
In this paper, we establish some new Simpson type inequalities for functions, whose first deriva-tive in absolute value is (s, P)-function by using Hölder, power-mean and Hölder-İşcan inequalities. After that, we compare the results obtained with both Hölder, Hölder-İşcan integral inequalities and prove that the Hölder-İşcan integral inequality gives a better approximation, than the Hölder inequality. Also, some applications to special means of real numbers are also given.
- MakaleYalnız künye2025Scopus SJRQ2Investigation of interior seed effects on levitation force in Melt-Grown YBCO superconductors by experimental and numerical methods
Öztürk, Ufuk Kemal; Abderrahmane, Babe Cheikh; Uzun, Oğuzhan; Abdioğlu, Murat; Güner, Sait Barış; Quéval, Loïc
This study introduces a novel Top-Interior Multi-Seeding Melt Growth (TI-MSMG) technique for fabricating high-performance YBCO bulk superconductors and explanations some physical background based on FEM modelling. The depth of the interior seed was gradually changed as 0, 2 and 4 mm (samples S0, S2 and S4, respectively) from the upper surface of the samples. By incorporating an interior seed into the precursor pellet, the TI-MSMG method enables systematic control over grain morphology and critical current density distribution. Magnetic levitation and guidance forces were measured using a three-axis force measurement system, and a two-dimensional finite element method (FEM) model based on the H-formulation of Maxwell’s equations was developed to simulate the electromagnetic behaviour of the superconductors with different seed positions. Experimental and modelling results reveal that samples incorporating an interior seed (S2) exhibit significantly enhanced levitation and guidance forces compared to S0 and S4, attributable to improved inter-domain interactions and morphological consistency, so a better current coupling. The numerical simulations accurately reproduced the experimental findings, confirming the validity of the modelling approach. These findings indicate that the TI-MSMG process not only addresses some limitations of conventional top-seeding methods but also enhances levitation force performance through optimization of interior seed depth, thereby enabling more efficient and tailored designs for high-temperature superconducting systems such as magnetic levitation, energy storage, and superconducting motors.
- MakaleAçık Erişim2025Scopus SJRQ4THE EFFECT OF PERSON-ORGANIZATION FIT ON JOB PERFORMANCE IN THE CONTEXT OF ORGANIZATIONAL CITIZENSHIP BEHAVIOR
Kizil, Seda; Demir, Rahime Nur
In healthcare institutions, employees who experience a strong alignment between their personal values and those of the organization are more likely to demonstrate organizational citizenship behaviors, which in turn contribute to enhanced job performance. The primary purpose of this study is to investigate the mediating role of organizational citizenship behaviors in the relationship between person–organization fit and job performance. The research population consists of 530 employees working at Bayburt State Hospital, Türkiye as of 2023, and the sample includes 342 participants. The analysis results indicate that organizational citizenship behaviors have a direct and positive effect on job performance. Furthermore, the compatibility between the individual and the organization significantly and positively influences organizational citizenship behaviors. In addition, organizational citizenship behaviors are found to have a significant and positive impact on job performance. These findings highlight the important role that organizational citizenship behaviors play in enhancing employee performance. The results also reveal that organizational citizenship behaviors serve as a key mediating variable in the relationship between person–organization fit and job performance. This study provides important insights for the development of employee management and performance improvement strategies in the healthcare sector. In particular, efforts to strengthen the alignment between employees and the organization may foster higher levels of organizational citizenship behaviors, which can, in turn, positively influence job performance. Implementing strategies that support person–organization compatibility and encourage organizational citizenship behaviors can effectively enhance both employee satisfaction and the overall performance of healthcare institutions. Such strategies are essential for achieving long-term success in the healthcare industry.
- MakaleAçık Erişim2025Scopus SJRQ1The Effect of Self-Regulation on the Need for Psychological Help Through Happiness, Resilience, Problem Solving, Self-Efficacy, and Adjustment: A Parallel Mediation Study in Adolescent Groups
Akeren, İhsan; Çelik, Eyüp; Yayla, İbrahim Erdoğan; Özgöl, Mustafa
Introduction: Adolescence is a developmental period in which the risk of mental problems is high. Failure to resolve the problems encountered during this period may result in the need for psychological help. Based on the literature review, this study aimed to examine self-regulation, which has the potential to reduce adolescents’ need for psychological help, and the mediation of happiness, resilience, problem solving, self-efficacy, and adjustment through this skill. Methods: In the cross-sectional correlational survey design study, 1013 adolescents (542 girls, 471 boys, mean age: 15.04 ± 1.75 years) aged 12–19 years and studying in middle and high school in Bayburt, Turkey were reached. Seven different questionnaires, valid and reliable in adolescent groups, were used to measure the study variables. Results: Correlation results showed that all predictors were positively correlated with each other and negatively correlated with the dependent variable, the need for psychological help. After testing the assumptions, the results of the parallel mediation analysis showed that happiness, problem solving, self-efficacy, and adjustment fully mediated the effect of self-regulation on the need for psychological help. Another finding is that resilience is not a predictor of psychological distress. Conclusions: The results are important because they provide insight for those working in the field of adolescent mental health in terms of understanding the factors through which self-regulation reduces the need for psychological help.
AtıfScopus10WoS9OpenAlex12İncele - MakaleAçık Erişim2025Scopus SJRQ4DFT Calculations, ADME Analysis and Molecular Docking Studies of the Compound AHTPO With the Digestive Enzyme Trypsin Found in Cold-Adapted Fish Species
Tanrıverdi, Erdi Anıl; Tanrıverdi, Aslıhan Aycan; Yıldıko, Ümit
For the special amine 7-Amino-3-(4-aminophenyl)-5H-thiazolo[3,2-a]pyrimidin-5-one (AHTPO), previously reported experimental biological activities served as the foundation for further studies. Computational chemistry and molecular simulation techniques were subsequently applied to investigate AHTPO. Its interactions with trypsin enzymes derived from cold-adapted fish species were examined. The compound's biological activity and pharmacokinetic properties were assessed using DFT calculations, molecular docking, and ADME analyses. Molecular docking results indicated that AHTPO exhibits strong binding affinities with the 1A0J and 2TBS enzymes, with the binding to 2TBS being energetically more favorable. Additionally, ADME analysis revealed that while the AHTPO shows potential for pharmaceutical applications, its gastrointestinal absorption and blood-brain barrier permeability may present certain limitations. Regarding its electronic and optical properties, AHTPO's high dipole moment and polarizability values enhance its flexibility and adaptability in biological environments. The HOMO-LUMO energy gap suggests that the AHTPO achieves a balance between stability and reactivity, enabling high activity in biomolecular interactions. These findings highlight the promising pharmacological potential of AHTPO in binding with trypsin enzymes, suggesting its viability as a therapeutic agent.
AtıfScopus1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ3Revealing the Behavioral Effects of Hair Dye Exposure in Rats by Sociability, Anxiety and Recognition Assessments
Boyuk Ozcan, G.; Bozok, U.G.; Korkusuz, B.B.; Demirboga, B.; Rabetian, S.; Orkun Erkilic, T.
Background: Most people use hair dye to change their hair color. The aim of this study was to investigate how hair dye affects rat behavioral tests. Methods: This study examines the effects of hair dye exposure on the Three-Chambered Sociability, open field, elevated plus maze and novel object recognition tests. Group 1 (n=8) was dyed twice, Group 2 (n=8) was dyed four times, Group 3 (n=8) was dyed eight times and Group 4 (n=8) was water-treated and dried eight times. Result: The control group (Group 4) sniffed certain objects more in the first occupied cage. The groups exposed to less dye explored for longer periods (p<0.05 higher in Groups 1 and 2 than in the control group). In the open field test, Group 2 showed more scratching, hunger and urination. The control group showed more cage interaction than the other groups (p<0.05). In the elevated plus maze test, no difference in time was found between the groups. In conclusion, hair dye chemicals may affect rat behavior, but neurotoxicity and oxidative stress tests are required to confirm this.
- DüzeltmeAçık Erişim2025Scopus SJRQ1Correction to: Scientific habits of arguing minds: enhancing online argumentation to foster SHOM (Educational technology research and development, (2025), 10.1007/s11423-025-10474-1)
Çakiroğlu, Ünal; Güven, Onurhan; Yaman, Havva; Güven, Ebru Mazlum
Authors' affiliation were incorrect in the article as originally published and have been corrected.
- MakaleAçık Erişim2025Scopus SJRQ2Fear of Falling Avoidance Behavior on Daily Living Activities and Physical Activity in Older Adults: A Cross-Sectional Study
Türkmen Keskin, Sultan; Sönmez Sari, Ebru; Canbulat, Şahinde; Öztürk, Fatma Özlem
The aim of this study was to investigate the effect of avoidance behavior due to fear of falling on dependency levels in activities of daily living and physical activity levels in older adults. This study is a cross-sectional research design. Data were collected between November 2023 and March 2024. A total of 506 individuals aged 65 years and over participated in the study (mean age 71.26). It was determined that the older adults had low level of fear of falling avoidance behaviors were fully independent in activities of daily living and had low level of physical activity. The multiple linear regression analysis showed that age, marital status, education, living with and fear of falling avoidance behavior affected daily living activities; age, place of residence, gender, income status, chronic disease status, and fear of falling avoidance behavior affected physical activity level (R2 = 0.183; R2 = 0.197, respectively). This study revealed the necessity of interventions to prevent fear of falling avoidance behaviors in order to increase the activities of daily living and physical activity levels among older adults.
AtıfScopus14WoS12OpenAlex15İncele - MakaleAçık Erişim2025Scopus SJRQ2Importance of Melt Cleaning Parameters on Reliability of Tensile Properties in A356 Alloy
Tigli, Ahmet; Uslu, Emin; Çolak, Murat; Dispinar, Derya
This study examines how melt treatment and pouring temperature affect the microstructure and mechanical properties of A356 aluminum alloy. Samples were cast under degassed, non-degassed, and upgassed conditions at 725, 750, and 775 °C. Melt quality was assessed using the reduced pressure test (RPT) and the bifilm index (BI), while microstructural features were analyzed via SEM and EDS. Tensile testing and Weibull statistics were used to evaluate mechanical performance and variability. Results showed that by improper degassing the reproducibility of mechanical properties decreased regardless of hydrogen content of the melt. When bifilm index (BI) was high (> 50 mm), the ductility was lowered and caused greater variability in strength and elongation. SEM confirmed large oxide films in samples, linked to the brittle fracture. The work also highlighted the importance of melt cleaning parameters for the reliability of cast aluminum alloys regardless of the hydrogen content.
AtıfScopus3WoS3OpenAlex3İncele - MakaleYalnız künye2025Scopus SJRQ1Characterization and in situ bioprotective efficacy of reuterin E81 produced by Limosilactobacillus reuteri E81 in white cheese model
İspirli, Hümeyra; Öztürk, Hale İnci; Dertli, Enes
This study focused on characterization and in situ application of reuterin E81, a potent antimicrobial compound produced by Limosilactobacillus (L.) reuteri E81, in white cheese. Strain E81 harbored the gene island containing pdu-cbi-cob-hem clusters responsible for reuterin production and this led to investigation of reuterin production for this strain. Initially, reuterin was synthesized from glycerol and characterized using NMR and FT-MIR analyses. Specific 1H and 13C NMR peaks confirmed the presence of reuterin components such as 3-hydroxypropionaldehyde and acrolein, while FT-MIR spectra indicated a distinct carbonyl (C=O) stretching band at 1717 cm−1, characteristic of aldehyde groups of reuterin system. Reuterin E81 showed dose dependent fungistatic and bactericidal effects, with complete inhibition of Gram-negative ones at lower doses. In white cheese production, four groups were prepared, including control and experimental groups with or without glycerol addition. The challenge test conducted over 30 days of cold storage demonstrated that white cheese samples containing L. reuteri E81 and glycerol achieved a significant reduction in microbial loads, with Escherichia (E.) coli counts decreasing from 6.4 log CFU/g to undetectable levels, which was attributed to in situ reuterin production. Meanwhile, total aerobic mesophilic bacterial counts declined progressively. These findings highlight the potential of in situ reuterin production as a natural strategy to enhance the microbiological safety of white cheese. However, it also inhibited the growth of S. thermophilus and L. reuteri cultures. The inhibitory effects of reuterin on beneficial lactic acid bacteria suggest the need for further optimization to balance food safety with starter culture viability.
AtıfScopus5WoS5OpenAlex6İncele - MakaleAçık Erişim2025Scopus SJRQ2Existence of solutions for anisotropic parabolic Ni-Serrin type equations originated from a capillary phenomena with nonstandard growth nonlinearity
Ayazoglu, Rabil; Akkoyunlu, Ebubekir; Naghizadeh, Zohreh
We consider an initial boundary value problem for a class of anisotropic parabolic Ni-Serrin type equations with nonstandard nonlinearity in a bounded smooth domain with homogeneous Dirichlet boundary condition. Because the nonlinear perturbation leads to difficulties (it does not have a definite sign) in obtaining a priori estimates in the energy method, we had to modify the Tartar method significantly. Under suitable assumptions, we obtain the global existence, decay and extinction of solutions.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ1Broadband Multilayer Absorber Design Using Double-Stage Cognitive Seeker Optimization Algorithm
Hasar, Ugur Cem; Kaya, Yunus; Korkmaz, Huseyin; Iliev, Teodor
In this paper, a double-stage cognitive seeker optimization (DSC-SO) algorithm is developed for evaluating optimum design parameters of broadband microwave absorbers. The algorithm not only gives freedom of selecting different number of layers and optimizing the order of layers and their thickness in different stages (double-stage) but also utilizes a cognitive search to improve the optimization. Contributions of the cognitive search and the two stages of our algorithm are first examined to show its efficiency. Then, its performance has been evaluated for two different optimization problems (a broadband absorber for one incidence angle and a broadband absorber with multiple incidence angles) in comparison with similar algorithms in the literature. It has been shown that our algorithm determines either fewer number of layers or smaller overall absorber thickness or both when compared with the results of other algortihms. Finally, the effect of fabrication tolerance is conducted to examine the importance of fewer number of layers.
AtıfScopus3WoS1OpenAlex3İncele - MakaleYayıncıda açık erişim2025Scopus SJRQ2Sustainable Optimization of Ohmic Heating–Assisted Extraction of Polyphenolics from Goji Berry (Lycium barbarum L.): LC–MS/MS Profiling and Blueness–Greenness Assessment
Kantar, Harun; Ecem Bayram, Nesrin
This study aimed to extract bioactive compounds from goji berry (Lycium barbarum L.) fruit using the ohmic heating–assisted extraction (OHAE) method and optimize the extraction conditions. In this context, firstly, the extraction conditions to be applied for the OHAE method were determined using the response surface method (RSM)-Box Behnken experimental design. During the study, temperature, holding time, and electrical field strength were determined as independent variables, while the total phenolic compound (TPC), total flavonoid compound (TFC), and antioxidant activity (DPPH) were selected as dependent variables. As a result of the optimization, the optimum conditions were determined to be 60 °C for the temperature, 60 min for the holding time, and 45 V/cm for the electrical field strength, and the composite desirability value of the model was 0.90. The highest experimental results for TPC, TFC, and DPPH were found to be 23.83 mg GAE/g, 7.33 mg QE/g, and 24.53 mg TE/g, respectively. In addition, the polyphenolic profiles of all extracts obtained under different process conditions were determined by LC–MS/MS, and rutin was the phenolic detected at the highest rate in the extracts. In addition, the blueness and greenness of the analytical method used in this study were evaluated using the BAGI and ComplexGAPI metrics, respectively. The results indicate that OHAE is an effective and sustainable method for extracting bioactive compounds from goji berries.
AtıfScopus5WoS5OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ1Disrupted miRNA Biogenesis Machinery Reveals Common Molecular Pathways and Diagnostic Potential in MDS and AML
Çevik, Kenan; Ay, Mustafa Ertan; Tombak, Anıl; Ay, Özlem İzci; Karakaş, Ümit; Erdal, Mehmet Emin
Background: Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal stem cell disorders in which disrupted post-transcriptional regulation contributes to aberrant hematopoiesis and leukemic transformation. The miRNA biogenesis machinery, which comprises Drosha, DGCR8, Dicer, TARBP2, and AGO1, ensures the precise maturation of miRNAs that control lineage commitment and proliferation. However, the extent to which alterations in this pathway reshape hematopoietic gene networks during myeloid disease evolution remains largely unexplored. Methods: Bone marrow samples from newly diagnosed, untreated MDS and AML patients and matched healthy controls were analyzed for the expression of five key miRNA biogenesis genes using quantitative real-time PCR. Statistical comparisons, correlation matrices, and ROC analyses were performed to characterize gene-expression differences. These results were integrated with multigene logistic modeling, decision-curve analysis, and exploratory random forest/SHAP approaches to evaluate molecular interactions and diagnostic relevance. Results: DROSHA, DICER1, and TARBP2 were significantly downregulated in both MDS and AML, suggesting impaired miRNA maturation and a loss of global post-transcriptional control. DGCR8 expression increased across higher-risk MDS groups, suggesting compensatory activation of the Microprocessor complex, whereas AGO1 levels remained relatively stable, consistent with partial maintenance of RISC function. Correlation analyses revealed a co-regulated DROSHA–TARBP2–AGO1 module. ROC, logistic, and machine learning models identified DGCR8 and DICER1 as the strongest diagnostic discriminators. The integrated five-gene signature achieved high discriminative performance (AUC ≈ 0.98) and showed promise but remains preliminary potential for clinical application. Conclusions: Our findings suggest that defects in miRNA biogenesis disrupt hematopoietic homeostasis, reflecting common mechanisms in MDS and AML. The dysregulation of DICER1, DGCR8, and TARBP2 offers insights into miRNA-driven leukemogenesis and may pave the way for miRNA-based diagnostic and therapeutic strategies, pending validation in larger cohorts. Although transcript-level data are provided, future studies should include functional validation to determine the impact on downstream miRNA processing and hematopoietic pathways.
- MakaleAçık Erişim2025Scopus SJRQ2An Integrated In Vitro and In Silico Investigation of the Bioactive Properties of Wild Glycyrrhiza glabra var. glandulifera
Kızıl, Hamit Emre; Ulcay, Sibel; Ekincioğlu, Yavuz; Öğütçü, Hatice; Ağar, Güleray
This investigation examined methanol extracts obtained from the whole plant (encompassing all organs except roots), flowers, and fruits of wild Glycyrrhiza glabra var. glandulifera, a liquorice cultivar indigenous to the Cappadocia region of Türkiye, constituting the first comprehensive in vitro and in silico analysis of this species within the region. Anatomical identification revealed distinctive structural characteristics, including thick-walled epidermal cells in the stem, organized clusters of collenchyma cells, and well-defined sclerenchyma layers encompassing the vascular bundles. The petiole exhibited a characteristic heart-shaped morphology containing three vascular bundles, while foliar analysis demonstrated the presence of stomata on both adaxial and abaxial surfaces, accompanied by a bifacial mesophyll arrangement. The extracts demonstrated remarkable antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, as well as various fungal species. Furthermore, significant cytotoxic activity was observed against non-small cell lung cancer (H460), with the whole plant extract exhibiting IC50 values of 117.8 µg/mL (24 h) and 105.6 µg/mL (48 h). Flower extracts demonstrated IC50 values of 116.8 µg/mL (24 h) and 112.7 µg/mL (48 h), while fruit extracts displayed superior potency with IC50 values of 104.4 µg/mL (24 h) and 63.09 µg/mL (48 h). Molecular docking analyses, conducted utilizing AutoDock Tools 1.5.6 and BIOVIA Discovery Studio Visualizer 4.5, revealed significant protein-ligand interactions, yielding optimal binding energy and inhibition constant values of -9.57 kcal/mol and 96.92 nM, respectively. The RMSD values were calculated based on structural variations between ligand-protein complexes during re-docking procedures. These findings underscore the substantial biological potential of Glycyrrhiza glabra var. glandulifera from Cappadocia, necessitating further comprehensive investigation.
AtıfScopus6WoS6OpenAlex5İncele - MakaleAçık Erişim2025Scopus SJRQ4Readaptation of the functional reserves of elite mixed martial arts athletes during long-term rehabilitation after musculoskeletal injuries
Savenko, Andrii; Chernozub, Andrii; Turkmen, Mutlu; Olkhovyi, Oleh; Shtefiuk, Ivan; Korchagin, Mukola
Purpose. To study the distinctive characteristics of functional reserve readaptation in elite Mixed Martial Arts (MMA) athletes during long-term rehabilitation after musculoskeletal injuries using various physical therapy protocols. Material & Methods. The study examined 24 elite athletes who sustained musculoskeletal injuries after competitions, predominantly involving the neuromuscular system and limb ligaments. 50 % of the athletes had previously practiced Muay Thai boxing, while the others specialized in Greco-Roman wrestling before MMA. The monitoring of the athletes’ functional reserve readaptation during rehabilitation lasted seven months. The study included four control stages (before injury, and after two, five, and seven months of rehabilitation), each accompanied by a set of test loads designed to evaluate the effectiveness of the readaptation. To assess the adaptive and compensatory responses of the body to the applied loads, a series of blood biomarkers was analyzed, including creatine phosphokinase, lactate dehydrogenase, cortisol, and creatinine. Changes in body composition were tracked using bioimpedance analysis. Results. The most noticeable signs of adaptation failure in elite MMA athletes occurred during the first two months of rehabilitation. Compared to pre-injury data, both groups of athletes showed a decrease in baseline creatine phosphokinase and creatinine levels. This was accompanied by an increase in lactate dehydrogenase activity in their blood serum, marking a significant drop in the body’s functional reserves and overall resistance. During the three-month rehabilitation period, athletes exhibited only partial signs of functional readaptation, despite the implementation of protocols that significantly differed from standard physical therapy approaches. Moreover, a decrease in blood cortisol concentration in response to physical load was detected in both groups, suggesting a low level of resistance and the need for additional energy supply. During the last eight weeks of the seven-month rehabilitation program, exercises replicating 85-90% of MMA technical skills facilitated both the activation and enhancement of functional readaptation. Modifications to the protocols led to an increase in baseline creatinine and creatine phosphokinase levels, along with a decrease in lactate dehydrogenase activity in both groups. Simultaneously, the changes observed in biochemical blood markers in response to the test loads indicated activation of mechanisms supporting short-term adaptation. Conclusions. The findings indicate the limited effectiveness of standard physical therapy protocols in supporting the readaptation of functional reserves among elite MMA athletes during long-term rehabilitation. Despite the high resistance of physiological systems to physical loads recorded before injury, the lack of sufficient muscular activity during the five-month rehabilitation period led to the manifestation of compensatory reactions. Restructuring the rehabilitation protocols with adjusted training loads and exercises simulating 75-80% of combat movements positively influenced the athletes’ recovery. The study results helped to identify and analyze the low effectiveness of functional reserve readaptation observed in many elite MMA athletes during long-term rehabilitation after musculoskeletal injuries.
AtıfOpenAlex3İncele