Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Dertli, Enes(11)
- Mercan, Emin(10)
- Ustabulut, Mete Yusuf(10)
- Ayata, Ümit(9)
- Kaya, Yunus(9)
- Sert, Durmuş(9)
- Ertugrul, Mehmet(8)
- Hasar, Ugur Cem(6)
- Tozlu, Alperen(6)
- Öner, Erdal(6)
- Abdioglu, Murat(5)
- Aktaş, Esat(5)
- Arslaner, Ayla(5)
- Bayram, Ozkan(5)
- Bulut, Mehmet(5)
- Ecem Bayram, Nesrin(5)
- Gürleyen, Levent(5)
- Karaduman, Ruken(5)
- Kaya, Feridun(5)
- Kul, Sinan(5)
- Türkmen, Mutlu(5)
- İspirli, Hümeyra(5)
- Artar, Musa(4)
- Arı, Ari(4)
- Azili, Kenan(4)
- Azimkhani, Amin(4)
- Bayraktar, Bülent(4)
- Dayı, Özkan(4)
- Gül, Volkan(4)
- Izginli, Mucahit(4)
- Kaban, Abdullatif(4)
- Kalay, Erbay(4)
- Kuzey, Memet(4)
- Ozdemir, Gazi(4)
- Ozturk, Gokhan(4)
- Ozturk, Hamdullah(4)
- Ozturk, Kemal(4)
- Saatchian, Vahid(4)
- Sarikaya, İsmail(4)
- Tekce, Emre(4)
Yayınlar
- Kitap BölümüYalnız künye2021Analyzing financial performance of paper products, printing and publishing companies traded at BIST via fuzzy TOPSIS methodology
Çelik, Pelin
- MakaleAçık Erişim2021Scopus SJRQ1District heating and electricity production based on biogas produced from municipal WWTPs in Turkey: A comprehensive case study
Abusoglu, Aysegul; Tozlu, Alperen; Anvari-Moghaddam, Amjad
In this paper, district heating (DH) potentials of the wastewater treatment plants (WWTPs) based on their biogas, electricity, and heat productions are considered. Two district heating scenarios are developed: (i) DH Scenario I which is based on both excess biogas storage of the WWTP and exhaust gas of the cogeneration with the actual power output, (ii) DH Scenario II which is based on the exhaust gas of the cogeneration with the increased power output using all the biogas produced. In DH Scenario I, it is found that 458 dwellings can be heated via the DH system proposed considering only the waste heat of the cogeneration. In addition, the natural gas consumption of 1112 dwellings with the same annual heating load can also be met using the purified biogas. In DH Scenario II, the electricity production could be increased to 1643 kWh by burning all the biogas produced in the cogeneration plant. In this scenario, the annual heating load of 755 dwellings in Gaziantep province can be covered using the waste heat in the DH system. The payback period for the DH Scenario I is calculated as 2.5 years, while for the DH Scenario II, it is obtained as 2 years.
AtıfScopus27WoS28
İncele - MakaleAçık Erişim2021Scopus SJRQ3A novel approach to finding optimum operating conditions of design factors for the grinding experiment
Uçurum, Metin; Özdemir, Akın; Teke, Çağatay; Tekin, İlker
The efficiency of grinding experiments is an important issue for many industries. In this paper, a central composite design-based methodology was proposed to investigate the four design factors that affect the particle sizes. The four design factors were specified as mill speed (% of Nc), ball filling ratio (fc), powder filling ratio (jb) and grinding time (min). Another important issue was how to obtain an optimum operating condition for four design factors. For this particular purpose, a novel dual response optimization model was proposed using the particle sizes (d 10, d 50, and d 90) and the span value concept. This proposed approach was compared to the desirability function-based optimization concept. The verification study of the experiment was also carried out. The results of the grinding experiment runs showed that the optimum operating conditions were mill speed 73.495% of Nc, ball filling ratio 0.354, powder filling ratio 0.157, and grinding time 70 min. In addition, d 10, d 50, and d 90 were found 3.31 µm, 12µm, and 45.6 µm, respectively. The span value was also found at 3.52.
AtıfScopus3WoS3OpenAlex4İncele - MakaleAçık Erişim2021Scopus SJRQ3A novel weighted mean-squared error optimization model to obtain optimal conditions of adsorption factors for a lead removal process
Özdemir, Akın; Teke, Çağatay; Serencam, Hüseyin; Uçurum, Metin; Gündoğdu, Ali
Lead (Pb) removal process from wastewater is an important issue to prevent health problems for people. For this particular purpose, a low-cost adsorbent may be beneficial for improving the adsorption capacity for the Pb removal process. The aims of this paper are four-fold. First of all, a D-optimal experimental design was selected to reduce experimental runs and its cost. Second, the effect of four adsorption design factors, stirring speed (rpm), adsorbent dosage (g), pH level, and initial metal concentration (ppm), was examined. Also, the yellow natural stone, which is from Bayburt, Turkey, was used as a cheap adsorbent for the Pb removal process from the solu-tion. Third, a novel weighted mean-squared error optimization model was developed to obtain optimal adsorption levels for adsorption factors. Besides, a verification study was conducted to verify the results of the adsorption experiment. Finally, the lead (Pb(II)) removal capacity of the yellow Bayburt stone was obtained to be 46.031 mg/g, and the results of the experiment from the proposed methodology showed a good performance for the removal study.
- Derleme MakaleAçık Erişim2021Scopus SJRQ1Alkali-activated and geopolymer materials developed using innovative manufacturing techniques: A critical review
Gökçe, H.S.; Tuyan, M.; Nehdi, M.L.
The manufacturing of geopolymers and alkali-activated materials for precast and cast in-situ construction applications could be achieved using suitable production techniques, such as one-part production, pre-setting pressure and hot pressing, two-stage concreting, and 3-dimensional printing. Adequate selection and tailoring of the manufacturing methodology are imperative for overcoming characteristic application problems of these materials and achieving eco-efficiency and superior engineering properties. With distinctive benefits including rapid solidification, lower cost, saving natural resources, less energy consumption, and reduced carbon footprint, alkali-activated and geopolymer composites have emerged as a strong contender for replacing conventional concrete in diverse construction applications. Critical analysis of the literature on innovative production methods indicates that the one-part production technique is promising for the eliminating design complexity of these mixtures. The pre-setting pressure and hot pressing applications would allow the achievement of superior physical and mechanical characteristics in a short period of time, especially for the precast industry. The workability and setting problems of alkali-activated materials could be overcome using the two-stage concreting methodology. To be used in 3D printing of alkali-activated and geopolymer materials, remarkable development is required in terms of rheological aspects. Accordingly, this paper surveys pertinent and recent literature and critically reviews the state-of-the-art of alternative production techniques of alkali-activated and geopolymeric materials, along with its use in recent applications, identifies pertinent knowledge gaps, and defines future research directions.
AtıfScopus155WoS137OpenAlex167İncele - MakaleAçık Erişim2021Scopus SJRQ1Forecasting outbreak of COVID-19 in Turkey; Comparison of Box–Jenkins, Brown's exponential smoothing and long short-term memory models
Guleryuz, Didem
The new coronavirus disease (COVID-19), which first appeared in China in December 2019, has pervaded throughout the world. Because the epidemic started later in Turkey than other European countries, it has the least number of deaths according to the current data. Outbreak management in COVID-19 is of great importance for public safety and public health. For this reason, prediction models can decide the precautionary warning to control the spread of the disease. Therefore, this study aims to develop a forecasting model, considering statistical data for Turkey. Box-Jenkins Methods (ARIMA), Brown's Exponential Smoothing model and RNN-LSTM are employed. ARIMA was selected with the lowest AIC values (12.0342, -2.51411, 12.0253, 3.67729, -4.24405, and 3.66077) as the best fit for the number of total case, the growth rate of total cases, the number of new cases, the number of total death, the growth rate of total deaths and the number of new deaths, respectively. The forecast values of the number of each indicator are stable over time. In the near future, it will not show an increasing trend in the number of cases for Turkey. In addition, the pandemic will become a steady state and an increase in mortality rates will not be expected between 17–31 May. ARIMA models can be used in fresh outbreak situations to ensure health and safety. It is vital to make quick and accurate decisions on the precautions for epidemic preparedness and management, so corrective and preventive actions can be updated considering obtained values.
AtıfScopus39WoS28OpenAlex47
İncele - MakaleAçık Erişim2021Scopus SJRQ4Associations between prl/rsai polymorphism and some performance traits in holstein cattle reared under organic condition
Ozdemir, M.; Sonmez, Z.; Aksakal, V.
The aim of this study was to ascertain the RsaI polymorphism of the Prolactin (PRL) gene of 186 organically reared Holstein cattle by PCR-RFLP method, in order to reveal the genetic variation of the population, and to reveal the relationship between PRL/RsaI genotypes and some milk yield traits. In the study, the RsaI-/- genotype frequency, RsaI+/+ genotype frequency and RsaI-/+ genotype frequency of Holstein cattle were determined as 0.26, 0.22 and 0.52, respectively. The RsaI- gene frequency was 0.52, and the RsaI+ gene frequency was 0.48. Hardy-Weinberg genetic equilibrium test showed that the distribution of genotype frequencies was determined to be in genetic equilibrium. The relationships between PRL/RsaI polymorphism and the examined milk yield traits were not significant. As a result, an economic and safe method PCR-RFLP for the detection of genetic markers, was successfully used in the determination of the 3 genotypes (RsaI-/-, RsaI-/+, and RsaI+/+) of Prolactin gene in Holstein cattle reared under organic condition, and the results was similar with previously reported literature.
AtıfScopus10WoS7OpenAlex5İncele - MakaleAçık Erişim2021Scopus SJRQ1A green nano-biosynthesis of selenium nanoparticles with Tarragon extract: Structural, thermal, and antimicrobial characterization
Yilmaz, Mustafa Tahsin; İspirli, Humeyra; Taylan, Osman; Dertli, Enes
In this study, tarragon extract was used as a reducing agent to perform green nano-biosynthesis of selenium nanoparticles (SeNPs). The synthesized SeNPs were characterized using measurements of UV–Vis spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy disperse analysis of X rays (EDAX), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometer (XRD) and differential scanning analysis (DSC). Synthesis of nanoparticles was confirmed by observing a peak at 212 nm in UV-VIS, indicating the surface plasmon resonance of SeNPs. Tarragon extract enabled a stable dispersion of SeNPs, giving rise to formation of the nanoparticles in the shape of quasi-spheres without clustering with the sizes between 20 and 50 nm. The SeNPs were shown to be in the form of nanocrystals, having Se embedded in the nanostructure with high thermal stability (a high resistance to thermal process over 200 °C). The SeNPs synthesized with tarragon extract could remarkably increase the inhibition zones from approximately 13 to 18 mm against the pathogenic bacteria and from 10 to 14 mm, 17–36 mm, 8–12 mm, 15–24.5 mm and 9–14 mm, against A. alternata, A. niger, A. parasiticus, B. cinerea, F. oxysporum and P. chrysogenum, respectively.
AtıfScopus86WoS71OpenAlex83İncele - MakaleAçık Erişim2021Scopus SJRQ3Land Use Impact of Maritime Pine and Eucalypt: A Life Cycle Assessment Study
Ferreira, José; Esteves, Bruno; Ayata, Ümit; Cruz-Lopes, Luisa; Domingos, Idalina
The forestry sector in Portugal faces important challenges, resulting in an increased incidence of fires and the action of pathogens, which puts the sustainability of forest resources at risk. Due to the economic, social, and environmental importance of forests, this work assessed the land use environmental impact of maritime pine and eucalypt standing in Portuguese forests. SimaPro software was used to translate the inventory table results into land use impact category. The ILCD 2011 Midpoint+ method was chosen to assess the “land use” environmental impact that focuses on soil quality and its indicator (kg carbon deficit), which describes the changes in soil organic matter associated with land interventions. The results showed that for the first rotation time, the land use impact category per cubic meter of maritime pine is 18423 kg C deficit and 23430 kg C deficit for eucalypt, which means that the land use impact category of eucalypt is 27% higher than the impact of maritime pine.
AtıfScopus2WoS1OpenAlex1İncele - MakaleAçık Erişim2021Scopus SJRQ1Modelling of the discharge response to climate change under RCP8.5 scenario in the Alata river basin (Mersin, SE Turkey)
Yıldırım, Ümit; Güler, Cüneyt; Önol, Barış; Rode, Michael; Jomaa, Seifeddine
This study investigates the impacts of climate change on the hydrological response of a Mediterranean mesoscale catchment using a hydrological model. The effect of climate change on the discharge of the Alata River Basin in Mersin province (Turkey) was assessed under the worstcase climate change scenario (i.e., RCP8.5), using the semi-distributed, process-based hydrological model Hydrological Predictions for the Environment (HYPE). First, the model was evaluated temporally and spatially and has been shown to reproduce the measured discharge consistently. Second, the discharge was predicted under climate projections in three distinct future periods (i.e., 2021–2040, 2046–2065 and 2081–2100, reflecting the beginning, middle and end of the century, respectively). Climate change projections showed that the annual mean temperature in the Alata River Basin rises for the beginning, middle and end of the century, with about 1.35, 2.13 and 4.11 °C, respectively. Besides, the highest discharge timing seems to occur one month earlier (February instead of March) compared to the baseline period (2000–2011) in the beginning and middle of the century. The results show a decrease in precipitation and an increase in temperature in all future projections, resulting in more snowmelt and higher discharge generation in the beginning and middle of the century scenarios. However, at the end of the century, the discharge significantly decreased due to increased evapotranspiration and reduced snow depth in the upstream area. The findings of this study can help develop efficient climate change adaptation options in the Levant’s coastal areas.
AtıfScopus16OpenAlex19İncele - MakaleAçık Erişim2021Scopus SJRQ3An application of finite element method in material selection for dental implant crowns
Sensoy, Abdullah T.; Çolak, Murat; Kaymaz, Irfan; Findik, Fehim
Materials used for dental crowns show a wide range of variety, and a dentist's choice can depend on several factors such as patient desires, esthetics, tooth factors, etc. One of the most important issues for implant surgery is the primary stability and it should be provided to minimize the risks of screw loosening, failed osseointegration, or nonunion. The current study aims to present the Finite Element Analysis (FEA)-based material selection strategy for a dental crown in terms of reducing the aforementioned risks of dental implants. A virtual surgery mandible model obtained using MIMICS software was transferred to the ANSYS and material candidates determined using CES software were compared using FEA. The results indicated that Zr02+Y2O3 (zirconia) has shown a 12.79% worse performance compared to Au83-88/Pt4-12/Pd4.5-6 alloy in terms of abutment loosening. On the other hand, zirconia is the most promising material for dental crowns in terms of the stability of the bone-implant complex. Therefore, it may show the best overall performance for clinical use. Moreover, as suggested in this study, a better outcome and more accurate predictions can be achieved using a patient-specific FEA approach for the material selection process.
AtıfScopus4WoS4OpenAlex5İncele - MakaleAçık Erişim2021Scopus SJRQ2Dielectric characteristics and electrical conductivity behavior of graphene/Al2O3/p-type silicon structure
Kaymak, Nuriye; Oz Orhan, Elif; Bayram, Ozkan; Bilge Ocak, Sema
Graphene nanosheets (Gns) obtained by the chemical vapor deposition (CVD) method have been employed for the fabrication of Graphene/Al2O3/p-type silicon (Si) structure. The Raman, scanning-electron-microscopy (SEM) and transmission-electron-microscopy (TEM) have been used to analyze the morphology and structural features of the graphene nanosheet. The dielectric features and electrical-conductivity of Graphene/Al2O3/p-type Si have been studied in the frequency range 10 kHz–400 kHz and in the voltage range, −4 V to +4 V at 300 K. The obtained experimental outcomes imply that electrical conductivity and dielectric features of Graphene/Al2O3/p-type Si were found out to be powerful functions of frequency and applied bias voltage. It can be seen that almost all of the interface states between metal and silicon contribute to modify of dielectric features of Graphene/Al2O3/p-type Si structure.
AtıfScopus6WoS6OpenAlex6İncele - MakaleAçık Erişim2021Scopus SJRQ3Aggressive environment performance of low energy cements containing fly ash
Gokce, H. Suleyman; Simsek, Osman
In this study, compressive strength performance of boron active belite cement containing fly ash at the ratios of 0, 10, 20, and 30% (by weight of cement) is researched against aggressive environments; sea water, 5% sodium sulphate solution, and 5% ammonium nitrate solution in addition to tapping water. Alternative low energy cement i.e., Portland-composite cement was used and its results were compared with those of boron active belite cement. Early strength losses (reaching up to 40%) of the boron active belite cement with incorporation of fly ash up to 30% were found to be less pronounced than those (reaching up to 51%) of Portland-composite cement in tapping water. Although, the losses were highly compensated with the prolonged curing period (90 days), boron active belite cement and Portland-composite cement kept their losses up to 14% and 36%, respectively. Residual mechanical properties (reaching up to 67%) of boron active belite cement against aggressive environments were found almost similar to those of Portland-composite cement in presence of 30% fly ash. In conclusion, the study shows that belite cements with low fly ash contents can be a reasonable alternative for specific applications such as mass concrete, hot weather concreting especially in aggressive environments.
AtıfScopus3WoS1OpenAlex5TR Dizin1
İncele - MakaleAçık Erişim2021Scopus SJRQ1High-pressure homogenisation of sheep milk ice cream mix: Physicochemical and microbiological characterisation
Sert, Durmuş; Mercan, Emin
The effect of high-pressure homogenisation (HPH) treatment (0, 25, 50, 75, or 100 MPa) of mix on the physicochemical, textural, and microbiological characteristics of sheep milk ice cream was determined. Textural properties of the mix were not affected by HPH. However, HPH increased L*, a*, and b* values of the mix. In HPH-treated mix samples, the mean particle diameter was lower compared with the control. The hardness value of ice cream changed from 43.0 to 58.1 N, and HPH increased it depending on the increasing pressure. The highest overrun (58.3%) was determined in control, whereas the lowest overrun (35.8) was found in HPH-100. Melting time and first dripping time were increased depending on the increasing pressure of HPH, while HPH decreased the melting rate. HPH treatment of mix significantly reduced the microbial loads of ice cream samples. Consequently, HPH treatment can enhance the hardness, melting, and microbiological properties of ice cream from sheep milk.
AtıfScopus12WoS12OpenAlex11İncele - MakaleYalnız künye2021Scopus SJRQ2Characterization of physicochemical and antioxidant properties of Bayburt honey from the North-east part of Turkey
Bayram, Nesrin Ecem; Kara, Hasan Hüseyin; Can, Aslı Muslu; Bozkurt, Fatih; Akman, Perihan Kübra; Vardar, Sevgi Umay; Çebi, Nur; Yılmaz, Mustafa Tahsin; Sağdıç, Osman; Dertli, Enes
The aim of this study was to determine the physicochemical properties, bioactive substance content, and microbiological quality of sixty different honey samples collected from twelve different regions of Bayburt, Turkey. The samples were analyzed for their sugar, moisture, total phenolic, total flavonoid contents, and water activity, conductivity, pH values and colour, antiradical activity, and DSC properties. As a result of physicochemical analyses, it was determined that the samples examined complied with the standard values defined in the Turkish Food Codex in terms of the parameters examined. The results of the study showed that the total phenolic content (219.43-768.82 mg GAE kg−1), total flavonoid content (31.29-118.7 mg CAE kg−1) and DPPH (12.98%-94.79%) parameters differ widely among the honey samples. A principal component analysis (PCA) was applied to correlate the characteristics of honey with honey samples collected from different regions. This is the first comprehensive and original report about the physicochemical properties of honey produced in Bayburt, a region close to the Anzer region where the most expensive honey, Anzer honey, is produced.
AtıfScopus19WoS17OpenAlex23İncele - MakaleAçık Erişim2021Scopus SJRQ2Detection of fructophilic lactic acid bacteria (FLAB) in bee bread and bee pollen samples and determination of their functional roles
Ispirli, Hümeyra; Dertli, Enes
In this study, bee bread and bee pollen samples were characterized in terms of presence of fructophilic lactic acid bacteria (FLAB). Following discrimination and identification of FLAB strains, their functional roles were determined. Genotypic characterization of FLAB strains revealed the presence of 27 distinct strains belonging to Lactobacillus kunkeei (21), Fructobacillus fructosus (3), Lactobacillus plantarum (2), and Leuconostoc mesenteroides (1) strains. In terms of functional roles, all FLAB strains demonstrated high levels of autoaggregation and hydrophobicity properties whereas L. kunkeei and F. fructosus strains did not tolerate bile salts and low pH conditions. A low level of antibiotic resistance was observed among FLAB strains and importantly FLAB strains demonstrated high levels of antibacterial and antifungal activities where strain specific properties played roles. The highest exopolysaccharide (EPS) production yields were obtained for L. kunkeei AP15, AP37 and L. mesenteroides AP-40 which produced 2.79, 2.01, and 5.37 g/L EPS, respectively. Practical applications: Bee bread and bee pollen are among beneficial bee products produced and consumed in all over the world. Production of bee bread relies on the fermentation process of bee pollen where a special LAB group FLAB plays roles. Despite the increment of the importance of these products for human consumption, there is a lack of knowledge for the microbial composition of these products. In this study, FLAB strains were isolated and identified from bee bread and bee pollen samples, and their technofunctional role was determined. The FLAB strains would be evaluated as starter cultures for production of bee products under industrial conditions.
AtıfScopus28WoS23OpenAlex29İncele - MakaleAçık Erişim2021Scopus SJRQ2Characterization of properties of Vanadium, Boron and Strontium addition on HPDC of A360 alloy
Gursoy, Ozen; Colak, Murat; Tur, Kazim; Dispinar, Derya
The demand for lighter weight decreased thickness and higher strength has become the focal point in the automotive industry. In order to meet such requirements, the addition of several alloying elements has been started to be investigated. In this work, the additions of V, B, and Sr on feedability and tensile properties of A360 has been studied. A mold design that consisted of test bars has been produced. Initially, a simulation was carried out to optimize the runners, filling, and solidification parameters. Following the tests, it was found that V addition revealed the highest UTS but low elongation at fracture, while B addition exhibited visa verse. On the other hand, impact energy was higher with B additions.
AtıfScopus13WoS12OpenAlex14İncele - MakaleAçık Erişim2021The relationship between attitudes toward the teaching profession, occupational resilience belief, and extra-role behavior: A moderated mediation model
Kara, Kürşad; Ada, Kübra
This study aims to examine the direct and indirect relationships between pre-service teachers’ attitudes toward the teaching profession, their occupational resilience beliefs, and their tendency to engage in extra-role behaviors within the framework of structural equation modeling. A relational survey model was used to design this quantitative investigation. The sample comprises 430 pre-service teachers who enrolled at four different programs at a state university in Turkey. The study used the attitudes toward teaching profession scale, the occupational resilience beliefs scale for pre-service teachers, and the extra-role behaviors scale (teacher form) as data collection tools. The researchers created hypothesis models examining the mediating and moderated mediating role of the occupational resilience belief in the effect that attitudes toward the teaching profession have on extra-role behaviors and tested these models within the framework of structural equation modeling. As a result of the study, it was found that the relationship strength between the attitudes toward the teaching profession, the occupational resilience belief, and extra-role behaviors was moderate. The study determined that occupational resilience belief plays a mediating role in the effect of pre-service teachers’ attitudes toward the teaching profession on extra-role behaviors. According to the results of the moderated mediation analysis, the influence of this indirect effect on extra-role behaviors varies according to the type of program studied, even though it does not differ significantly according to the class level of the pre-service teachers. This indirect effect is provided at the best level for pre-service teachers in the mathematics education program. However, the study concluded that the indirect effect influence significantly weakened in the Turkish education program.
AtıfScopus2OpenAlex3İncele - MakaleYalnız künye2021Scopus SJRQ2Asymmetric reduction of aromatic heterocyclic ketones with bio-based catalyst Lactobacillus kefiri P2
Baydaş, Yasemin; Kalay, Erbay; Şahin, Engin
Abstract: Chiral heterocyclic secondary alcohols have received much attention due to their widespread use in pharmaceutical intermediates. In this study, Lactobacillus kefiri P2 biocatalysts isolated from traditional dairy products, were used to catalyze the asymmetric reduction of prochiral ketones to chiral secondary alcohols. Secondary chiral carbinols were obtained by asymmetric bioreduction of different prochiral substrates with results up to > 99% enantiomeric excess (ee). (R)-1-(benzofuran-2-yl)ethanol 5a, which can be used in the synthesis of pharmaceuticals such as bufuralols potent nonselective β-blockers antagonists, Amiodarone (cardiac anti-arrhythmic), and Benziodarone (coronary vasodilator), was produced in gram-scale, high yield and enantiomerically pure form using L. kefiri P2 biocatalysts. The gram-scale production was carried out, and 9.70 g of (R)-5a in enantiomerically pure form was obtained in 96% yield. Also, production of (R)-5a in terms of yield and gram scale through catalytic asymmetric reduction using the biocatalyst was the highest report so far. This is a cost-effective, clean and eco-friendly process for the preparation of chiral secondary alcohols compared to chemical processes. From an environmental and economic perspective, this biocatalytic method has great application potential, making it a green and sustainable way of synthesis. Graphical Abstract: [Figure not available: see fulltext.]
AtıfScopus8WoS8OpenAlex9İncele - Kitap BölümüYalnız künye2021Socioeconomic Analyses on Covid-19, Underdevelopment, and Inequalities
Gültekın, Ömer Faruk