Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Dertli, Enes(115)
- Kaya, Yunus(50)
- Ayata, Ümit(48)
- Şahin, Engin(48)
- İspirli, Hümeyra(46)
- Bayraktar, Bülent(42)
- Şenay, Volkan(41)
- Can, Zehra(39)
- Özen, Soner(37)
- Bayram, Sinan(35)
- Pat, Suat(35)
- Öztürk, Mesut(35)
- Ecem Bayram, Nesrin(34)
- Esmer, Yusuf(34)
- Battal, Fetullah(33)
- Artar, Musa(32)
- Öner, Erdal(32)
- Korkmaz, Şadan(31)
- Yilmaz, Mustafa Tahsin(31)
- Ertugrul, Mehmet(30)
- Mercan, Emin(30)
- Hasar, Ugur Cem(29)
- Kutlu, Naciye(28)
- Özdemir, Akın(27)
- Kul, Murat(26)
- Cuce, Erdem(25)
- Kamiloğlu, Aybike(25)
- Bayram, Ozkan(24)
- Sefali, Abdurrahman(24)
- Sert, Durmuş(24)
- Çolak, Murat(24)
- Ayazoglu, Rabil(22)
- Gıdık, Betül(22)
- Maden, Sedat(22)
- Ustabulut, Mete Yusuf(22)
- Uçurum, Metin(22)
- Akeren, Zahide(21)
- Dirican, Ebubekir(21)
- Kara, Yakup(21)
- Abdioglu, Murat(20)
Yayınlar
- MakaleAçık Erişim2023Effect of Reboxetine Treatment on BDNF, Synaptophysin, and PSD-95 Levels in the Spinal Dorsal Horn of Rats with Diabetic Neuropathy
Yücel, Nazli Turan; Üçel, Umut Irfan; Özkay, Umide Demir; Ulupinar, Emel; Can, Ozgur Devrim
Objective: It is known that neuropathic pain is accompanied by alterations in the levels of neurotrophic factors and synaptic proteins in the microenvironment of the spinal dorsal horn. Such changes contribute to hyperalgesia and allodynia processes; thus, analgesic drugs can exert their pharmacological effects by affecting the expressions, levels, or functions of these endogenous substances. In this study, based on the knowledge that reboxetine (a selective noradrenaline reuptake inhibitor) has the potential for antihyperalgesic efficacy in diabetic neuropathy, we aimed to examine the probable effects of this drug on diabetes-induced changes in brain-derived neurotrophic factor (BDNF), synaptophysin (the pre-synaptic marker of synaptic integration), and postsynaptic density-95 (PSD-95) (the postsynaptic marker of synaptic integration) levels in the superficial laminae of the dorsal horn.Methods: Experimental diabetes was induced by a single-dose injection of streptozotocin (STZ) (50 mg/kg) in rats. After four week-long induction period of painful diabetic neuropathy, rats were treated orally with 8 mg/kg reboxetine for two weeks. Hyperalgesia responses were evaluated by using the Randall-Selitto and Hargreave's tests. Following the pain tests, immunohistochemical studies were performed.Results: Two weeks of reboxetine administration increased the reduced paw withdrawal thresholds and shortened the paw withdrawal latencies of diabetic rats in neuropathic pain tests, indicating the antihyperalgesic efficacy of this drug. Moreover, augmented BDNF and synaptophysin levels in diabetic rats reversed by reboxetine treatment. However, there was no alteration in the densities of PSD-95, in both STZ-diabetic and reboxetine-treated STZ-diabetic rats.Conclusion: The obtained results suggested that inhibition of central sensitization and modulation of spinal plasticity seem to be pharmacological mechanisms underlying reboxetine's antihyperalgesic effects on diabetic rats. However, further studies are still needed to clarify the exact mechanism of action.
AtıfWoS1OpenAlex1
İncele - MakaleAçık Erişim2023The success of critical velocity protocol on predicting 10000 meters running performance
Çabuk, Baris; Demirarar, Onur; Cin, Merve; Çabuk, Refik; Özçaldiran, Bahtiyar
Background and Study Aim The study aims to evaluate which of the critical velocity (CV) estimates of the three widely used models and the best-fit model successfully predict the running performance of 10000 meters. Material and Methods The group of participants in this study consisted of 11 British endurance athletes. The CV estimations were obtained from the models with the athletes' running velocity and exhaustion times of 1500, 3000, and 5000 meters (m). The information was taken from a website where the results of the British athletes are recorded. In terms of selecting endurance athletes, the data of the athletes who ran 1500 m, 3000 m, 5000 m, and 10000 m in the same two years were included in this study. By fitting the data into mathematical models, the CV estimates of the three mathematical models and the individual best-fit model were compared with the 10000 m running velocity. The CV estimates were obtained by fitting the relevant data on the running velocity, exhaustion time, and running distance of the three running distances of athletes to each of the three mathematical models. Results 10000 m running velocity and times of the athletes corresponded to 19.65 +/- 1.26 km/h and 30.4 +/- 1.94 minutes, respectively. The CV values obtained from the three mathematical models and 10000 m running velocity were similar (p > 0.05). Although the lowest total standard error levels were obtained with the best individual fit method, the 10000 m running velocity was overestimated (p < 0.05). Conclusions Three mathematical models predicted 10000 meters of race velocity when an exhaustion interval between 2-15 minutes was used. Even though the mathematically most valid CV value was obtained with the best individual fit method, it overestimated the 10000 m running velocity. When comparing the values of CV and the velocity of running 10,000 meters, our study suggests using the model. This is because the model has the smallest effect size, and there is no statistically significant difference in the total standard error level between the model and the best-fit model.
AtıfWoS1İncele - MakaleAçık Erişim2023Beneficial Effect of Atomoxetine Treatment on Scopolamine-Induced Cognitive Impairments and Molecular Changes in Rats
Yucel, Nazli Turan; Ucel, Umut Irfan; Kandemir, Ummuhan; Can, Ozgur Devrim
Objective: Atomoxetine is a noradrenaline re-uptake inhibitory drug that is currently used in the pharmacological treatment of attention deficit/hyperactivity disorder in children, adolescents, and adults. Based on the findings that noradrenergic system is closely associated with learning and memory processes, dysfunction of this system might contribute to the pathophysiology of cognitive disorders. Therefore, atomoxetine, which alters the noradrenergic neurotransmission in the synaptic cleft, has a potential to modulate learning and memory functions in various areas of the central nervous system. In the present study, it was aimed to investigate the effects of atomoxetine treatment on the cognitive impairments in amnesic animals using behavioral and immunohistochemical methods.Methods: Male Sprague-Dawley rats (adult, weighing 250-300 g) were used in the experiments. Atomoxetine at doses of 3 or 6 mg/kg (i.p.) was administered to the rats for 14 days. Experimental amnesia was induced in the animals by applying scopolamine (0.5 mg/kg, i.p.) injection. Following the treatment protocol, Morris water maze and passive avoidance tests were conducted to assess spatial and emotional learning and memory parameters of rats, respectively. Piracetam (300 mg/kg daily for 14 days) was used as reference drug in these experiments. In addition, motor performances of the animals were evaluated by activity cage and Rota-rod tests. Subsequent to behavioral tests, rats were euthanized and immunohistochemical analyses were performed to determine the alterations in the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels in the hippocampi of the animals.Results: In the Morris water maze test, amnesic rats found the hidden platform slower and spent less time in the target quadrant compared to the healthy controls. On the other hand, atomoxetine treatments significantly decreased the escape latencies, and also increased the target quadrant time values of the amnesic animals at both doses. Data obtained from the passive avoidance test showed that second transition latency values of the amnesic rats were significantly shortened with respect to the control animals; while atomoxetine treatment prolonged these shortened values significantly. It was observed that atomoxetine did not alter motor coordination or spontaneous locomotor activities of animals. Moreover, this drug increased the BDNF and NGF levels in the hippocampal sub-regions which were diminished by scopolamine administration.Conclusion: The obtained findings showed that atomoxetine treatment significantly improved the impaired learning and memory performances of the rats induced by scopolamine administration. Furthermore, anti-amnesic effects of this drug were concomitant with increased neurotrophic factors levels in the hippocampal brain regions. These results suggest a notable therapeutic potential of this drug in the treatment of dementia and several cognitive disorders; however, it should be underlined they are needed to be confirmed by welldesigned clinical trials.
AtıfWoS3OpenAlex3İncele - MakaleAçık Erişim2023Analysis of telomere length in patients with COVID-19 and investigation into its relationship with clinical- demographic data
Savrun, Atakan; Dirican, Ebubekir
Purpose: Novel coronavirus disease 2019 (COVID-19) is an infectious disease unknown before the 2019 outbreak in Wuhan. This study evaluated telomere length in COVID-19 (+) and (-) samples with clinical-demographic parameters.Materials and Methods: DNA was isolated from COVID-19 (+) (n=70) and (-) (n=70) patients. Telomere length was determined by real-time-PCR (RT-PCR). The 2- increment increment Ct method was used to analyze the telomere length of the samples.Results: There were significant differences in creatinine, LDH, ferritin, WBC, NEU and CRP in COVID-19 (+) patients compared to COVID-19 (-) patients. The NEU/LYM (or N/L) ratio was found higher in the patients with COVID-19 (+), than in COVID-19 (-). On the other hand, our COVID-19 (+) patients (mean +/- std:0.93 +/- 0.58) had significantly shorter telomere lengths than the COVID-19 (-) (mean +/- std:1.26 +/- 0.76). Moreover, COVID-19 (+) male patients (mean +/- std:1.06 +/- 0.50) had longer telomere length than female patients (mean +/- std:0.76 +/- 0.54). Telomere length was significantly shorter in patients with COVID-19 (+) with high blood urea nitrogen (BUN), high creatinine, high hematocrit, high NEU levels, normal platelets (PLT), and low WBC levels.Conclusion: Our findings suggest that telomere length and blood parameter levels influence the severity of COVID-19. Blood parameters differed in patients with COVID-19 (+) and COVID-19 (-). As a result, increasing the number of similar studies in the future can demonstrate the significance of our findings.
AtıfWoS2OpenAlex2İncele - MakaleYalnız künye2023Scopus SJRQ2THE EFFECTS OF STRATEGY TRAINING ON THE USE OF IMPLICATIONS FROM THINK-ALOUD AND EYE-TRACKING DATA
Utku Bilici, Ozlem; Subasi, Gonca; Dolgunsoz, Emrah
Considering the critical role of readings strategies in L2 reading this study aimed to investigate the impact of strategy training on Turkish EFL learners' use of global reading strategies. 23 freshmen, enrolled in the ELT Department, participated in the study, and the data were collected through eye tracking and thinkaloud protocols. The results are encouraging for the use of reciprocal teaching, one of the comprehensionenhancing approaches to teach reading, in the EFL contexts. Eye tracking results, hand in hand with the think-aloud protocols' findings, revealed that the participants utilised global reading strategies more frequently to a statistically significant degree after the strategy instruction. Thus, it was concluded that strategy training was useful for the participants to improve their use of global reading strategies, and a recent technological tool can be purposefully integrated into the data collection procedure of educational research studies. Pedagogical implications on the strategy training for the employment of global reading strategies that would help students improve reading skills need to be given attention by teachers.
- MakaleAçık Erişim2023Scopus SJRQ1Structure-function-guided design of synthetic peptides with anti-infective activity derived from wasp venom
Boaro, Andreia; Ageitos, Lucia; Torres, Marcelo Der Torossian; Blasco, Esther Broset; Oztekin, Sebahat; de la Fuente-nunez, Cesar
Antimicrobial peptides (AMPs) derived from natural toxins and venoms offer a promising alternative source of antibiotics. Here, through structure-function-guided design, we convert two natural AMPs derived from the venom of the solitary eumenine wasp Eu-menes micado into a-helical AMPs with reduced toxicity that kill Gram-negative bacteria in vitro and in a preclinical mouse model. To identify the sequence determinants conferring antimicrobial ac-tivity, an alanine scan screen and strategic single lysine substitutions are made to the amino acid sequence of these natural peptides. These efforts yield a total of 34 synthetic derivatives, including alanine substituted and lysine-substituted sequences with stabilized a-helical structures and increased net positive charge. The resulting lead synthetic peptides kill the Gram-negative pathogens Escheri-chia coli and Pseudomonas aeruginosa (PAO1 and PA14) by rapidly permeabilizing both their outer and cytoplasmic membranes, exhibit anti-infective efficacy in a mouse model by reducing bacte-rial loads by up to three orders of magnitude, and do not readily select for bacterial resistance.
AtıfWoS34OpenAlex39
İncele - MakaleAçık Erişim2023Scopus SJRQ1Catecholaminergic and Cholinergic Systems Mediate Beneficial Effect of Vortioxetine on Diabetes-Induced Neuropathic Pain
Turan Yücel, Nazlı; Kandemir, Ümmühan; Üçel, Umut İrfan; Demir Özkay, Ümide; Can, Özgür Devrim
The therapeutic potential of vortioxetine on mechanical hyperalgesia/allodynia was investigated in rats with streptozotocin-induced diabetes, and its possible mechanism of action was elucidated in this study. The obtained findings demonstrated that subacute vortioxetine treatment (5 and 10 mg/kg for 2 weeks) increased the reduced paw-withdrawal thresholds of diabetic rats both in the Randall–Selitto and Dynamic plantar tests. Moreover, the falling latencies of animals did not change in the Rota-rod assessments. These results suggest that vortioxetine administration significantly improved diabetes-induced hyperalgesia and allodynia responses in the rats without affecting their motor coordination. The vortioxetine (5 mg/kg)-induced antihyperalgesic and antiallodynic effects were reversed by AMPT, yohimbine, ICI 118,551, sulpiride and atropine pre-treatments, suggesting the involvement of the catecholaminergic system, α2- and β2-adrenoceptors, D2/3 dopaminergic receptors and cholinergic muscarinic receptors in the exhibited pharmacological activity, respectively. Moreover, the data from the immunohistochemical studies indicated that the inhibition of c-Fos overexpression in dorsal horn neurons also mediates the beneficial effect of this drug. Vortioxetine induced no difference in plasma glucose levels in diabetic rats. If clinical studies confirm these findings, the concomitant beneficial effect of vortioxetine on mood disorders and its neutral activity profile on glycemic control may make it an alternative drug for the treatment of neuropathic pain.
AtıfScopus6WoS4OpenAlex6
İncele - MakaleAçık Erişim2023Scopus SJRQ2Determining consumers’ intent to purchase organic foods in emerging market: price perception affect in moderated mediation model
Yilmazel, Sefa Emre
The main purpose of this research is to explore whether consumers’ consciousness of health, environment and food safety concern affect their intention to purchase organic foods through attitude mediation and price perception moderation. In the study, a sample of consumers who buy organic food was determined. 386 data were collected in Turkey. Confirmatory factor analysis made in the Amos 22.0 program and hypothesis tests were carried out in the Process Macro with Model 14. The results indicated that consciousness of health, environment and food safety effect consumers’ organic food attitude positively. Further, consumer attitude towards organic food effect their purchase intention. In addition, price perception show moderating effect on this relationship. Moreover attitude mediation effect (full and partial) has been proven. With this study, a comprehensive model has been revealed for emerging countries regarding the purchase of organic foods. Price perception moderating effect between attitude and purchase intention has been proven.
AtıfScopus8WoS9OpenAlex9İncele - MakaleAçık Erişim2023Performing trajectory tracking control of an unmanned ground vehicle using fractional order terminal sliding mode controller
Sekban, Hayriye Tuǧba; Başçi, Abdullah
In this paper, fractional order terminal sliding mode control (FOTSMC) method is used for trajectory tracking control performance of an unmanned ground vehicle (UGV). Firstly, a kinematic controller is designed to estimate the linear and angular velocities of the vehicle. Then, a FOTSMC design is carried out to track the vehicle reference velocities. Terminal sliding mode control (TSMC) and sliding mode control (SMC) methods are also used to demonstrate the performance of the proposed controller. The simulation results show that the proposed controller improves the tracking error by about 13% over SMC and 6.146% compared to TSMC.
AtıfScopus3WoS3OpenAlex3İncele - MakaleAçık Erişim2023Scopus SJRQ2Optimizing and investigating durability performance of sandy soils stabilized with alkali activated waste tuff-fly ash mixtures
Yilmaz, Fatih; Kuvat, Ahmet; Kamiloğlu, Hakan Alper
The search for alternative environmentally-friendly materials to Portland cement is increasing its importance in geotechnical engineering as in other fields. In this study, alkali activated waste volcanic tuff (BT) and fly ash (FA) utilized as an alternative to conventional binders. The specific objectives of this paper were to, (1) optimize fly ash, waste tuff and activator content using Response Surface Methodology (RSM), (2) investigate the UCS performance of the optimum amount of alkali-activated fly ash and waste tuff mixtures as a binder in soil stabilization by comparing with various codes, (3) characterize the optimized parameters, (4) examine durability performances of the samples. Optimum binder and activator content and effect of waste tuff on strength characteristics were evaluated statistically with RSM approach. XRF, XRD, FTIR analyses were performed to verify the synthesized alkali activated material in the inner structures of the optimized samples. The durability and mechanical properties of samples stabilized with alkali activated binders against soaking condition, wetting-drying and were investigated. Destructive and non-destructive methods were employed to examine mechanical and durability characteristics. Unconfined compression strength, strength reduction ratio, soil deterioration, and water absorption capacity was taken into account to evaluate durability performances. UCS values of the stabilized samples were compared with limit UCS values suggested by several standards. As a result of the study it was determined that alkali activated waste tuff and fly ash mixture shows significant mechanical and durability performance in soil stabilization, and capable to use as an alternative to conventional non-green binders.
AtıfScopus6WoS4OpenAlex8İncele - MakaleYalnız künye2023Scopus SJRQ2Cr-substituted nanocrystalline Ni–Co ferrites: tuning dielectric, magnetic, structural, X-band microwave absorption, and characteristic properties
Teber, Ahmet; Sarac, Mehmet F.
The structural, characteristic, dielectric, and magnetic features of Co0.5Ni0.5CrxFe2 − xO4 (0.0 ≤ x≤ 1.0 with a step of 0.2 x-concentration) nanoparticles are prepared via the hydrothermal method. The investigation of characteristics, structural, and magnetic features of the produced nanoparticles are examined through XRD, FT-IR, SEM–EDS, TEM-SAED, and VSM, respectively. AC conductivity and the dielectric investigations are also reported. According to the XRD measurements, all samples have the M-type hexagonal crystal structure nanocrystallites of between 27 and 97 nm. Refined structural parameters using Rietveld analysis are carried out using the TOPAS refinement program. A good match was observed between the diffraction patterns obtained and calculated by Rietveld analysis. Moreover, the morphological analyses indicate that the relatively small spherical structures of Ni–Co ferrites particles can be seen to change from spherical to relatively oval-shaped with increasing chromium content. The results of the FT-IR study show that the spinel structure has formed as predicted because the expected range of absorption bands is present. According to magnetic measurements, Cr-substituted Ni–Co ferrite nanostructures reveal a relatively soft ferromagnetic property. The coercive field (Hc) variation has a propensity to decrease in relation to the Cr-concentration. The electromagnetic constitutive parameters are calculated from measured S-parameters (S11 and S21) using network analyzer and the return losses of the samples are then obtained to determine microwave absorption properties. According to the dielectric and magnetic tangent losses or dissipation factors, both dielectric and magnetic features can mutually reinforce in terms of microwave absorption properties in the X-band. The Cr2O3 impurity peaks obtained by XRD analysis have an effect on the microwave absorption properties. The results of the microwave absorption based on each concentration reveal that there exist electromagnetic wave absorptions between approximately 11 GHz and 12.4 GHz in the X-band. The absorption trend is also towards the Ku-band.
AtıfScopus3WoS3OpenAlex3İncele - MakaleYalnız künye2023Scopus SJRQ2Socioeconomic status and wellbeing as predictors of students' academic achievement: Evidence from a developing country
Erdem, Cahit; Kaya, Metin
The COVID-19 pandemic has deepened the effects of socioeconomic status (SES) and wellbeing (WB) on students' academic achievement, particularly in developing countries; thus, it becomes necessary to understand the nature of these concurrent relationships. This study aimed to explore the relationships between SES, WB and academic achievement, based on the data from the Programme for International Student Assessment (PISA) in 2018 within the Turkish context. In this cross-sectional study, we used hierarchical multiple linear regression analysis to explore how the independent variables predicted academic achievement in blocks based on data from 6890 students attending 186 schools. The study revealed that the model, including the independent variables, predicted students' achievement in reading, mathematics and science; however, the prediction level of demographic factors and domains of WB were very low, while SES had the highest prediction level. The results offer insights into the predictors of academic achievement and educational inequalities in the context of a developing country.
AtıfScopus35WoS28OpenAlex39İncele - MakaleYayıncıda açık erişim2023Scopus SJRQ1Designing New Model-Based Adaptive Sliding Mode Controllers for Trajectory Tracking Control of an Unmanned Ground Vehicle
Sekban, Hayriye Tugba; Basci, Abdullah
This paper proposes three new dynamic model-based adaptive sliding mode controllers (ASMC) for trajectory tracking control of unmanned ground vehicles (UGV). The controllers combine kinematic and dynamic control to achieve asymptotic stability and finite-time convergence and their stability is verified using the Lyapunov stability theory. The controllers are designed to address the challenges posed by uncertainties in vehicle dynamic parameters and outperform the sliding mode control (SMC) method in trajectory tracking control. The simulation results of the proposed controllers are also discussed in terms of performance metrics. The simulation results show that the controller proposed in rule 1 shows the better performance in terms of trajectory tracking, and then the controllers proposed in rules 2 and 3 have good performances, respectively. In addition, when the simulation results are compared, it is seen that the performance of all three proposed controllers is better than the SMC.
AtıfScopus12WoS10OpenAlex13İncele - MakaleYalnız künye2023Scopus SJRQ3An Investigation on the Behavior of 3D Steel Frames Under Progressive Collapse Effect Using Nonlinear Dynamic Analysis
Tayfur, Bilal; Daloǧlu, Ayșe T.
In this study, the nonlinear dynamic analysis of steel structures against progressive collapse was examined, and the adequacy and validity of the analysis duration defined in the regulation were investigated. In addition, the effects of the seismic resistance and design against progressive collapse constraints on the structure were investigated. An optimization algorithm was used in order to conduct the iterative process with appropriate sections. The frames were analyzed to perform one cycle as recommended in the UFC, and then the analysis duration was extended until at least five cycles had been completed. When the UFC was considered only, it was observed that while some of the designs were classified as safe within the duration specified in the UFC, the structural integrity was seen to get into danger in the subsequent cycles. When constraints related to seismic effect are also included in the process, it was seen that the threat disappeared for the frames examined. In addition, it was observed that the steel frame resisted progressive collapse scenarios by creating formations like Vierendeel beams.
AtıfScopus1WoS1OpenAlex2İncele - MakaleAçık Erişim2023Scopus SJRQ2Characterisation of dextran AP-27 produced by bee pollen isolate Lactobacillus kunkeei AP-27
Yilmaz, Mustafa T.; İspirli, Hümeyra; Alidrisi, Hassan; Taylan, Osman; Dertli, Enes
An exopolysaccharide (EPS) produced by bee pollen isolate Lactobacillus kunkeei AP-27 was characterised in this study. EPS monomeric composition of strain AP-27 was characterised by High-performance liquid chromatography (HPLC) analysis and glucose was the only sugar in the EPS repeating unit. Structural analysis of glucan AP27 by 1H and 13C Nuclear magnetic resonance (NMR) analysis demonstrated that this glucan was a dextran ((1→6)-linked α-D-glucose units as the main body) consisting very low level of (1 → 4)-linked α-D-glucose units (∼ 0.5 %). Dextran AP-27 had a degradation temperature of 308 °C that revealed its superior thermal strength identified by Thermogravimetric (TGA) and Differential scanning calorimetry (DSC) analysis. The molecular weight of dextran AP-27 was determined to be 25 kDa by Gel Permeation Chromatography (GPC) analysis. Crystallographic properties of dextran AP-27 was determined by X-ray diffraction (XRD) analysis that divulged its amorphous feature. Scanning Electron Microscopy (SEM) analysis was applied for microstructural characterisation of dextran AP-27 which revealed its regular sphere like characteristics. These findings suggest that Lactic Acid Bacteria (LAB) strains from different environments such as bee products can be the source for distinct EPS producer strains.
AtıfScopus9WoS8OpenAlex7İncele - MakaleYalnız künye2023Scopus SJRQ3A comparison of the associations between bone turnover markers and different sports fields: combat versus team sports
Yıldız, K.; Uzunçakmak, S. Karabulut; Halıcı, Z.; Özçelik, C.; Yazıcı, A.G.
Sedentary life brings risks that include osteoporosis, while physical activity has many benefits for health in general and the skeletal system. Irisin is a hormone-like myokine regulated by mechanical force and it contributes to cortical and trabecular bone mineral density. This study aimed to investigate the effects of different types of sports on bone health by measuring elite athletes’ fibronectin type III domain 5 (FNDC5), N-terminal collagen type I extension propeptide (PINP), and C-terminal cross-linking telopeptide of type I collagen (CTXI) levels. Combat sports athletes, team sports athletes, and sedentary control subjects were enrolled. Serum levels of proteins were measured by ELISA. FNDC5 levels of elite athletes were higher compared to the sedentary controls (P=0.0014). The highest FNDC5 level was measured in wrestlers among all considered groups. The PINP levels of the athletes were also higher than those of the sedentary control group (P=0.1431). The highest PINP level was determined in boxers. The CTXI levels of the athletes were lower than those of the sedentary control (P<0.0001). The lowest CTXI level was seen in boxers. The FNDC5 and PINP levels of combat sports athletes were higher than those of team sports athletes (P=0.0134 and P=0.0262, respectively), while the CTXI levels of combat sports athletes were lower than those of team sports athletes (P<0.0001). Our results indicated that FNDC5, PINP, and CTXI levels are associated with physical activity. The effect of the exercises performed by athletes of specific sports on bone health has not been studied in much detail before. Combining different exercises for athletes of a particular sport may be more beneficial for bone health.
- MakaleYalnız künye2023Scopus SJRQ2Yttrium-substituted Co0.5Ni0.5YxFe2-xO4 ferrites as microwave absorbers by investigating structural, magnetic, dielectric, and absorption characteristics
Teber, Ahmet; Sarac, Mehmet F.
The effect of Yttrium Substitution on Co0.5Ni0.5YxFe2- xO4 (0.0 ≤ x ≤ 1.0) Ferrites as Microwave Absorbers was investigated to include structural, magnetic, dielectric and X-band absorption properties. The main objective of this work is to enhance microwave absorption properties of materials with interesting dielectric/magnetic behaviors by doping rare earth element of Yttrium based on transition metals. The hydrothermal method was used to create Yttrium (Y) substituted nanoparticles, and the effects of Y-ion substitution on the characteristics, structural, magnetic features were examined by XRD, FT-IR, SEM-EDS, TEM-SAED, and VSM, respectively. Electromagnetic properties were obtained from microwave scattering parameters measured via a metal-backed transmission line and Nicholson-Ross Weir techniques using a vector network analyzer (VNA) in conjunction with an X-band waveguide set. Return loss (RL) values of the samples were obtained from the electromagnetic constitutive parameters (permittivity and permeability). According to the XRD measurements, hexagonal crystal structure of ferrite and YFeO3 as secondary phase nanocrystal sizes are between 11 and 67 nm. Refined structural parameters using Rietveld analysis are carried out using the TOPAS refinement program. A good match was observed between the diffraction patterns obtained and calculated by Rietveld analysis. Moreover, the morphological analyses indicate that the relatively small spherical structures of Ni-Co ferrites particles can be seen to change from spherical to hexagonal-shaped with increasing yttrium concentration. The results of the FT-IR study show that the spinel structure has formed as predicted because the expected range of absorption bands is present. According to magnetic measurements, the coercivity (Hc) results show a modest increase in porosity as the Y-content rises. The results revealed that the minimum RL value and bandwidth vary significantly with the amount of Yttrium in the mixture, indicating that the obtained structures will be useful for broadband microwave applications.
AtıfScopus10WoS11OpenAlex12İncele - MakaleYalnız künye2023Scopus SJRQ3Effects of electromagnetic radiation on neurogenesis and gene expression in amniocytes
Uzun, Coşar; Erdal, Nurten; İzci Ay, Özlem; Karakaş, Ümit; Derici Yildırım, Didem; Durukan, Hüseyin; Akdag, Mahmut Berat; Erdal, Mehmet Emin
The aim of the study was to investigate the genetic effects of commonly used radiofrequency on the amniocytes of pregnant women by examining the changes in the expression of genes related to signal transduction and neurogenesis induced by electromagnetic fields of radiofrequencies of 1800 and 2100 MHz by real-time PCR. Upon exposure of the amniocytes to electromagnetic radiation of 2100 MHz at high field strength, the expression levels of genes with important functions in the Wnt signaling pathways as well as neurogenesis-related genes were increased. The findings suggest that radiofrequency at high field strengths can have genotoxic effects during pregnancy.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2023Scopus SJRQ1Face presentation attack detection performances of facial regions with multi-block LBP features
Günay Yılmaz, Asuman; Turhal, Uğur; Nabiyev, Vasif
Biometric recognition systems are frequently used in daily life although they are vulnerable to attacks. Today, especially the increasing use of face authentication systems has made these systems the target of face presentation attacks (FPA). This has increased the need for sensitive systems detecting the FPAs. Recently surgical masks, frequently used due to the pandemic, directly affect the performance of face recognition systems. Researchers design face recognition systems only from the eye region. This motivated us to evaluate the FPA detection performance of the eye region. Based on this, in cases where the whole face is not visible, the FPA detection performance of other parts of the face has also been examined. Therefore, in this study, FPA detection performances of facial regions of wide face, cropped face, eyes, nose, and mouth was investigated. For this purpose, the facial regions were determined and normalized, and texture features were extracted using powerful texture descriptor local binary patterns (LBP) due to its easy computability and low processing complexity. Multi-block LBP features are used to obtain more detailed texture information. Generally uniform LBP patterns are used for feature extraction in the literature. In this study, the FPA detection performances of both uniform LBP patterns and all LBP patterns were investigated. The size of feature vector is reduced by principal component analysis, and real/fake classification is performed with support vector machines. Experimental results on NUAA, CASIA, REPLAY-ATTACK and OULU-NPU datasets show that the use of all patterns increased the performance of FPA detection.
AtıfScopus18WoS11OpenAlex19İncele - MakaleAçık Erişim2023Scopus SJRQ3Socio-economic determinants of environmental degradation: Empirical evidence for the Environmental Kuznets Curve
Gültekin, Ömer Faruk; Sayar, Ramazan; Ari, Yllmaz Onur
The aim of the paper is to examine socio-economic determinants of environmental degradation. The empirical study employs quantile regression which enables separate predictions for different levels of the dependent variable to be made. This study investigated 62 countries from low, middle and some high income countries for 1995-2019. The Environmental Kuznets Curve (EKC) is verified for the aforemented countries in analyzing the relationship between economic growth and carbon emissions using quantile regression. The study also revealed that the schooling rate has a pollution-increasing effect. In addition to the reducing effects of trade openness, democracy, and economic freedom variables on environmental degradation, the opposite effect of life expectancy at birth is observed, increasing environmental degradation. In this context, this paper concluded that the EKC hypothesis is not supported. The government should encourage pollution-reducing policies in low and middle income countries.
AtıfScopus4WoS3OpenAlex5İncele