Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Dertli, Enes(116)
- Şahin, Engin(48)
- Kaya, Yunus(46)
- Özen, Soner(46)
- İspirli, Hümeyra(45)
- Pat, Suat(44)
- Şenay, Volkan(42)
- Korkmaz, Şadan(36)
- Yilmaz, Mustafa Tahsin(33)
- Kutlu, Naciye(32)
- Cuce, Erdem(31)
- Öner, Erdal(31)
- Artar, Musa(30)
- Ertugrul, Mehmet(29)
- Hasar, Ugur Cem(29)
- Mercan, Emin(28)
- Bayraktar, Bülent(27)
- Bayram, Sinan(27)
- Can, Zehra(25)
- Ecem Bayram, Nesrin(25)
- Çolak, Murat(23)
- Özdemir, Akın(23)
- Cuce, Pinar Mert(22)
- Sert, Durmuş(22)
- Ayata, Ümit(21)
- Bayram, Ozkan(21)
- Dirican, Ebubekir(20)
- Abdioglu, Murat(19)
- Ayazoglu, Rabil(19)
- Birinci, Ahmet(19)
- Kamiloğlu, Aybike(19)
- Gerçek, Yusuf Can(18)
- Taylan, Osman(18)
- Tozlu, Alperen(18)
- Gul, Volkan(15)
- Hasar, Ugur C.(15)
- Kadakal, Mahir(15)
- Sagdic, Osman(15)
- Ergün, Mustafa(14)
- Kadakal, Huriye(14)
Yayınlar
- MakaleAçık Erişim2024Scopus SJRQ1Hypoglycaemic confidence levels and experiences related to the hypoglycaemia of patients with diabetes: A mixed methods study
Sönmez Sari, Ebru; Semerci Çakmak, Vahide; Çetinkaya Özdemir, Serap; Eşsiz Sefer, Betül
Aims: This study had three aims: to determine the hypoglycaemic confidence levels of participants, to identify factors affecting hypoglycaemic confidence levels of participants and to assess experiences related to hypoglycaemia of participants. Design: The explanatory–sequential–mixed method was used in this study. Methods: The quantitative stage included a sample of 177 people, and the qualitative stage included a sample of 18 people. Data of the study were collected between April and June 2023 with the Hypoglycemic Confidence Level Scale, Personal Information Form and Semi-Structured Interview Form. Descriptive statistics, independent samples t-test, one-way ANOVA and multiple linear regression analysis were used for quantitative data analysis. For the qualitative data analysis, content analysis was performed in the MaxQda program. Results: The scale items are scored between 1 and 4, and an increase in the score obtained from the scale indicates an increase in confidence levels. The mean hypoglycaemic confidence level score of the participants was 3. The data obtained in the qualitative stage were grouped under three main themes: Experiences Related to Hypoglycaemia, Reasons for Experiencing Hypoglycaemia and Managing Hypoglycaemia. Conclusion: Identifying hypoglycaemic confidence levels and hypoglycaemia experiences of patients with diabetes can guide health professionals, especially nurses, in promoting person-centred care interventions. Impact: The study discussed the hypoglycaemic confidence levels of diabetic patients and their experiences related to hypoglycaemia. The factors affecting the hypoglycaemic confidence level of the participants were educational status, income status, fear of experiencing hypoglycaemia, ability to self-administer insulin, receiving hypoglycaemia training and frequency of experiencing hypoglycaemia. The results of this study may provide guidance for the development of appropriate prevention and coping strategies for hypoglycaemia. Identifying the experiences of patients with diabetes with hypoglycaemia can guide health professionals, especially nurses, in promoting person-centred care interventions. Reporting Method: The Good Reporting of a Mixed Methods Study (GRAMMS) checklist was used for reporting. Patient or Public Contribution: No patient or public contribution.
AtıfScopus3WoS3OpenAlex4
İncele - MakaleAçık Erişim2024Scopus SJRQ2Effects of Recycled Asphalt Material and Natural Pozzolan as Additives of Hot-Mix Asphalt: A Field Study
Yilmaz, Bahadır; Şentürk, Mehmet Akif
Using existing resources more efficiently and effectively becomes important currently. The question of how to make the best use of resources arises in the choice between constructing new roads and improving deteriorated existing roads. It is also important to reduce the amount of consumption and cost of materials. This has emerged the need to use waste materials by recycling and reusing. In this study, a new hot-mix asphalt (HMA) mixture was developed using recycled asphalt pavement (RAP), which was obtained by excavating the surface of a road at the end of its service life, together with a waste material namely natural pozzolan (NP). The final obtained mixture was used as a wear layer on an active highway. Core specimens were extracted from the paved layer for one year and subjected to dynamic and mechanical laboratory tests. Adding NP improved the resistance of the HMA mixture under heavy seasonal effects and traffic loads. In addition, NP increased the tensile strength, making the HMA mixture more resistant to deformation than control and RAP HMA mixtures. Dynamic creep test results showed that the control asphalt mixture had the most deformation and that the RAP mixture with NP had the least. According to the laboratory results, NP addition increased the stability value of the control mixture by 40%. Especially in cold seasons, the role of NP was more evident. In the performance tests that were applied on core samples taken from the field, ITS values for September increased by 98%, and the deformation values obtained as a result of the dynamic creep test decreased by 12%. In summary, adding NP to RAP HMA improves the performance of the pavement and the cost-effectiveness of the environmentally friendly use of RAP in HMA.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2024Analysis of the nonlinear optical properties, vibrational spectra, DFT method and photovoltaic performance of cyanidin-3-rutinoside chloride
Sarıkaya, Ebru Karakaş; Ekincioğlu, Yavuz; Bahçeli, Semiha; Dereli, Ömer
This study aims to identify a cyanidin-3-rutinoside chloride that exhibits both photovoltaic performance and nonlinear optical properties, which may be utilized in the field of optoelectronics. Prior to investigating these properties, the stable structure must be determined. For this purpose, its conformational analysis is performed by the Molecular Force Field method with the spartan program. The exact nature of the stable configuration has been ascertained by empirical evidence. The energy of the stable configuration is -1654184.76 kcal/mol, and its dipole moment is 9.94 Debye. Cyanidin-3-rutinoside chloride has been investigated using experimental FT-IR and Raman spectroscopies. Meanwhile, the DFT method at the B3LYP/6-311 + + G(d, p) level was employed in order to study the simulated FT-IR and Raman spectra, the HOMO-LUMO analysis, the molecular electrostatic potentials (MEP), and the non-linear optical (NLO) characteristics of the title molecule. The HOMO and LUMO energies are − 6.45 and − 3.64 electron volts (eV), respectively, with a gap value of 2.81 eV. Additionally, the title compound’s open-circuit voltage, the transition density matrix light-harvesting efficiency, driving force, and binding energy were calculated with by taking photovoltaic cell properties into account. Furthermore, investigations of hole reorganization energy, electron reorganization energy, and total reorganization energy were carried out at the B3LYP/6-31G(d, p) level for the cyanidin-3-rutinoside chloride of interest. In addition, density of state calculations and NBO were made at the B3LYP/6-31G(d, p) level. We calculated the following values for LHE,,,,, and : 0.06, 2.45 eV, 0.20 eV, 0.56 eV, 0.50 eV, 0.57 eV and 1.06 eV, respectively.
AtıfScopus9WoS10OpenAlex12İncele - MakaleAçık Erişim2024Scopus SJRQ2Electrical properties of Al/CZTSe nanocrystal Schottky diode
Kişnişci, Z.; Özel, F.; Karadeniz, S.; Tuğluoğlu, N.; Özel, S.S.; Yüksel, Ö.F.
In this study, electrical changes in diode parameters of Schottky diodes that made of a kesterite semiconductor were examined under different temperatures. For this aim, Cu2ZnSnSe4 (CZTSe) nanocrystals were fabricated using the hot injection technique, and it was covered by spin coating on an ITO glass substrate. We was introduced the physical and structural analyses using scanning electron microscopy and X-ray spectroscopy. Current–voltage measurements were fulfilled at different temperature (from 100 to 325 K) under dark environment. It was observed that its electrical parameters were strongly affected by temperature.
AtıfScopus11WoS10OpenAlex10İncele - MakaleYayıncıda açık erişim2024Scopus SJRQ1Do we need a guideline for all: a qualitative study on the experiences of male athletes following anterior cruciate ligament reconstruction
Gökmen, Mehmet Yiğit; Çepikkurt, Fatma; Belibağlı, Mehmet Cenk; Uluöz, Mesut; Özyol, Funda Çoşkun; Bavlı, Özhan; Karıncaoğlu, Ergin; Uluöz, Eren; Türkmen, Mutlu
Background: Considering the low rate of qualitative studies on athletes with anterior cruciate ligament reconstruction (ACLR), aiming to access in-depth data, we thought that the utilization of the qualitative method would allow us to collect the appropriate and sufficient data to yield novel findings and achieve sound conclusions. The study’s aim was to investigate anterior cruciate ligament (ACL) injury experience processes in athletes who had undergone isolated ACLR, reveal the clinically related milestones, and highlight the necessary gaps. Methods: Semi-structured interview techniques, in-depth follow-up questions, and thematic analysis were used to explore the experiences of participants with isolated ACL injuries 1–3 years after surgical treatment. The study was conducted in the Orthopaedics and Traumatology outpatient clinic of the Adana City Training and Research Hospital and included 14 male athletes who had undergone isolated primary ACLR. The study group’s demographic and qualitative data were collected in the first week of September 2023. The member checking process was completed in the third following week. A thematic analysis checklist was used to ensure the reliability of the thematic analysis. The Consolidated Criteria for Reporting of Qualitative Research (COREQ) guidelines were followed. Results: The experiences of 14 patients (22.78 ± 3.76 years, all males) were summarized into four themes that emerged from the data analysis process: ‘The Distinctions in the Participants’ Experiences Regarding the Moment of Injury,’ ‘Gathering Information about the ACL Injury,’ ‘Factors That Facilitate The Treatment Process and Reinforce Positive Experiences,’ and ‘Desperate Plight: Main Points of Patients’ Negative Experiences.’ Based on the main themes, there were 14 subthemes. Conclusions: Our study revealed that varying perceptions of ACL injury presented by the participants, which were caused by all stakeholders, including themselves, the professional environment, family members, social network, and the healthcare staff, showed that the physical and psychological impacts of the injury were observed in different severity levels at each stage of the process. We believe that an extensive guide for athletes with ACL injuries that includes all components of well-being and displays the required details for the sports club/coach, family/companion, and physician.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ1Investigating the Effectiveness of Augmented Reality Technology in Science Education in Terms of Environmental Literacy, Self-Regulation, and Motivation to Learn Science
Arici, Faruk
Augmented Reality (AR) is a technology that provides users with an engaging learning experience by placing interactive virtual 3D models in natural environments. It is known that the use of AR technology in science education has many educational benefits. This study investigated the impact of AR technology on the development of environmental literacy, self-regulation skills, and motivation for science learning, which are increasingly important skills. Acquiring these high-level skills is essential for supporting students’ development in preventing environmental problems, addressing the motivation decrease seen primarily due to distance learning, and acquiring the self-regulation skills that have gained importance due to distance learning. The study was conducted with a quasi-experimental design on fifth-grade students, with one experimental (34) and one control (36) group. The findings were analyzed through MANOVA and content analysis. The results showed that AR technology supports environmental sensitivity, positive behavior, and the development of environmental knowledge and skills. In addition, AR technology has significant contributions in terms of self-regulation. Finally, it is recommended to use AR technology in science education to develop these variables and positively affect participants’ motivation for science learning.
AtıfScopus22WoS17OpenAlex18İncele - MakaleAçık Erişim2024Scopus SJRQ1Turkish validity and reliability of the Haptotherapeutic Well-Being Scale
Küçükkaya, Burcu; Işık, Hafsa Kübra; Rathfısch, Gülay
Objectives: Haptotherapy fosters a sense of unity between the body, mind, and emotions. In addition, it contributes to expanding the woman’s perception of her pregnancy and developing a more positive attitude towards pregnancy and childbirth. The study aims to examine the Turkish validity and reliability of the Haptotherapeutic Well-Being Scale, which will be used to evaluate the well-being levels of haptonomy and haptotherapy practices in women. Design: The study was methodological type. Methods: The study conducted between October 20 and December 20, 2023, with 242 women who volunteered to participate by sharing forum pages on social media (Facebook, Instagram) via the web. Data were collected using a personal information form, including sociodemographic and obstetric characteristics and the Haptotherapeutic Well-Being Scale. Results: The Haptotherapeutic Well-Being Scale consists of 14 items and five sub-dimensions. In confirmatory factor analysis, all path coefficients were statistically significant (p < 0.001). The overall Cronbach’s Alpha and sub-dimension values of the scale are above 0.90. There is a positive and very strong correlation between all sub-dimensions of the scale (p < 0.001). Conclusion: The Haptotherapeutic Well-Being Scale was found to be valid and reliable for the Turkish sample. Trials registration: https://clinicaltrials.gov identifier NCT06467188; registered June 14, 2024.
AtıfScopus1WoS1OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ2Reflective Polarization Conversion with Multi-Functional, Ultrathin Metasurface for Ku-and K-Band Applications
Teber, Ahmet
Reflective polarization conversions with a simplistic design of an ultrathin, single-layered, and multi-functional anisotropic metasurface as a polarization converter is utilized for Ku-and K-band applications. The designs with two substrate thicknesses (0.095λ0 and 0.069λ0, respectively) are capable of a cross-polarization converter (CPC) and a linear-to-circular (LTC) polarization conversion. The design with 0.095λ0 thickness achieves a CPC between 17.96 and 26.90GHz with the efficiency of more than 90% and a relative bandwidth of 40% under normal incidence. It maintains angular stability by altering the oblique incidence angles up to 300 with greater than 80% of the PCR in the K-band. Meanwhile, an LTC in two frequency bands, 10.30-10.53GHz and 28.65-29.70GHz, is also numerically demonstrated. The second design with 0.069 λ0 thickness provides a CPC above the PCR value of 87% in the frequency range from 10.46-23.05GHz (covering the entire Ku-and part of the K-band) with angular stability of 40 above the PCR value of 80%. In the meantime, an LTC with relative bandwidth of 75% in the frequency range from 9.53-9.79&24.74-25.27GHz is numerically revealed. These polarization converters exhibit relatively good performances of facile structure and multi-functional properties, which can be useful in Ku-and K-band applications.
AtıfScopus5WoS3OpenAlex5TR Dizin1
İncele - MakaleAçık Erişim2024Scopus SJRQ1A Step towards Sustainable Education: Does an Entrepreneurial Teacher Nurture Creativity?
Saygın, Muhammet; Say, Serkan; Öztürk, İsmail Yavuz; Gülden, Bahadır; Kaplan, Kadir
This study explores the relationship between teachers’ entrepreneurial behaviors and their creativity-nurturing behaviors, with a particular emphasis on sustainability in education. While previous studies have typically examined entrepreneurship and creativity as separate concepts, often focusing on their individual dimensions, this study underscores the significance of integrating entrepreneurial and creative competencies to promote sustainable educational practices. By highlighting how teachers’ entrepreneurial and creative skills contribute to sustainable education, this study addresses the broader impact these competencies have on meeting the evolving needs and expectations of students, families, and society. This approach supports the development of a more resilient and adaptive education system that can thrive over time. The research involved 1396 classroom teachers from the Mersin province of Turkey. Analysis of the data revealed a strong positive correlation between teachers’ entrepreneurial behaviors and their creativity-nurturing behaviors, indicating that teachers who exhibit higher levels of entrepreneurial traits are more likely to engage in practices that foster creativity or that teachers who exhibit higher levels of creativity nurturing behaviors are more likely to engage in entrepreneurial practices among their students. Thus, the importance of the high-level relationship between entrepreneurial behaviors and creativity-enhancing behaviors in improving sustainability in education has been revealed. This study highlights the need to integrate entrepreneurial skills into teaching practices to support a sustainable educational framework.
AtıfScopus2WoS1OpenAlex4İncele - MakaleAçık Erişim2024Scopus SJRQ1The Effects of Virtual Reality Intervention Before Total Knee Arthroplasty on Pain, Anxiety, and Vital Signs
Güneş, Hüseyin; Sarıtaş, Serdar
Objective: In this study, the effects of a virtual reality intervention before total knee arthroplasty on pain, anxiety, and vital signs were investigated. Methods: This randomized controlled study with a pretest-posttest design was conducted with 130 patients included in experimental (n = 65) and control (n = 65) groups. Data were collected using a patient information form, the numeric rating scale (NRS), a vital signs form, and the state anxiety inventory. The patients in the experimental group watched a 20-minute video consisting of sea, forest, waterfall, and animal visuals using virtual reality goggles. Vital signs were recorded before and after the intervention. Vital signs were recorded on the same timeline in the control group, without any intervention. Results: The patients in the experimental group displayed lowered anxiety and pain levels and improvements in their vital signs, except for temperature. There were statistically significant differences between the experimental and control groups, except for temperature and diastolic blood pressure (p < .05). Conclusion: The virtual reality intervention reduced pain, anxiety, systolic and diastolic blood pressure, heart rate, and respiratory rate. It is recommended to be implemented before surgery.
AtıfScopus9WoS8OpenAlex11İncele - MakaleAçık Erişim2024Scopus SJRQ2Evaluating STC-1 and STC-2 mRNA expressions in Schizophrenia patients with increased oxidative stress; [Évaluation des expressions d'ARNm de STC-1 et STC-2 chez des patients schizophrènes présentant un stress oxydatif accru]
Karabulut Uzunçakmak, Sevgi; Özcan, Halil; Dirican, Ebubekir; Tavacı Özçelik, Ayşegül
Introduction: Schizophrenia is a chronic psychiatric disorder characterized by cognitive impairment. Oxidative stress is associated with disease progression in patients with schizophrenia. Stanniocalcin (STC)-1 and STC-2 are two proteins commonly expressed in mammals belonging to the stanniocalcin family and they are involved in oxidative stress. The aim of this study is to investigate STC-1 and STC-2 mRNA expressions in schizophrenia patients with altered oxidative stress parameters. Methods: For this purpose, 70 patients with schizophrenia and 40 healthy individuals were recruited for the study. Peripheral blood samples were obtained from all participants. Glutathione (GSH) activities, superoxide dismutase (SOD) activities, and malondialdehyde (MDA) levels were measured. STC-1 and STC-2 expressions were assessed by real-time polymerase chain reactions. Results: SOD activity levels were lower in patients than in healthy individuals (p = 0.0309), while the patients’ MDA levels were higher (p = 0.039). STC-1 and STC-2 expressions were lower in patients than in healthy individuals (p = 0.1049 and p < 0.0001, respectively). Furthermore, these two genes had a positive correlation among the patients (r = 0.435, p = 0.0025). According to area under the curve (AUC) values, STC-2 (AUC = 0.8332, p < 0.0001) had better diagnostic power than STC-1 (AUC = 0.6167, p = 0.1037). Conclusions: The expression of stanniocalcins in schizophrenia was investigated here for the first time. Decreased STC-2 expression in patients with schizophrenia with increased oxidative stress parameters may guide the understanding of the pathophysiological mechanisms caused by oxidative stress, which may be increased in cognitive diseases such as schizophrenia, and it also has the potential to be a prognostic factor that can be used in the diagnosis of schizophrenia.
- MakaleAçık Erişim2024Scopus SJRQ3Occupational Safety and Hidden Risks in a Furniture Factory: A Comprehensive Assessment of Hazards Related to Noise, Lighting, Thermal Comfort, and Dust Exposure
Özdemir, Mustafa; Albayrak, Sirer
This study assessed the occupational health and safety conditions in a furniture manufacturing facility, focusing on key environmental factors such as noise, lighting, thermal comfort, and dust exposure. Noise measurements recorded levels as high as 95.3 dB(A) during CNC machine operations, exceeding legal exposure limits of 87 dB(A), posing significant risks to workers’ hearing health. Lighting assessments showed levels ranging from 134 to 247 lux in production lines, which falls below the recommended threshold of 300 lux for adequate visibility. Thermal comfort was evaluated with temperature readings at 14.2 °C and relative humidity at 43%, revealing marginal comfort conditions that could reduce worker efficiency and satisfaction. Dust exposure measurements indicated respirable dust concentrations reaching 3.69 mg/m³ in the cutting department, which is close to the permissible exposure limit of 5 mg/m³, raising concerns about long-term respiratory health. These findings suggest several measures to improve workplace safety, including enhanced engineering controls, mandatory personal protective equipment (PPE), improved lighting systems, optimised thermal conditions, and advanced ventilation to reduce dust exposure. This comprehensive evaluation provides critical insights for improving furniture factories’ occupational health and safety practices.
AtıfScopus6WoS6OpenAlex3İncele - DüzeltmeAçık Erişim2024Scopus SJRQ1Correction to: Salivary apelin hormone response and dysfunctional attitudes in adolescents in Türkiye: a relational screening model (BMC Psychology, (2024), 12, 1, (64), 10.1186/s40359-024-01551-w)
Kirbaş, Zila Özlem; Bayraktar, Bülent; Aktaş, Elif Odabaşi
Following publication of the original article, it came to the journal’s attention that the order of the citations (following citation of reference 22) was incorrect. The order has since been corrected in the published article.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ1Energy-driven TBM health status estimation with a hybrid deep learning approach
Li, Yongsheng; Zhang, Limao; Pan, Yue; Tapkın, Serkan; Song, Xieqing
This study provides a hybrid deep learning approach that enables the researchers to estimate the Tunnel Boring Machine (TBM) health status during excavation process using energy consumption data. By analyzing the energy forms and paths in the tunneling process, the key energy factors' consumption performance behavior affecting TBM safety is identified. The Ensemble Empirical Mode Decomposition (EEMD) method and a Convolution neural network-Long short term memory-Depth Neural Network (CNN-LSTM-DNN, CLDNN) model are integrated for Health Performance Parameter (HPP) prediction. A classification method is constructed by the Generative Adversarial Imputation Networks (GAIN) model for health status estimation. The SHapley Additive exPlanations (SHAP) method is performed to quantify the relationships between energy consumption and system health status. A tunneling case in Singapore is used to test the effectiveness of the developed methodology. It is found that (1) the proposed method provides TBM cutter wear and cooling oil prediction with a R-square (R2) of 0.8591 and 0.8727, respectively, and (2) classification results indicate that the estimation F1-score of 0.9863 can be achieved based on health status evaluation indicator (HSEI). The novelty of the proposed approach lies in its capabilities of (1) fully extracting and utilizing the energy consumption information in every regard to predict TBM health performance; (2) providing a good one-step-ahead health status estimation for the TBM excavation process. Therefore, this study proposes a feasible direction for the application of energy consumption data in TBM health status estimation.
AtıfScopus17WoS15OpenAlex17İncele - MakaleYalnız künye2024Scopus SJRQ1Variations of natural frequencies of masonry minarets due to environmental effects
Yanik, Yusuf; Aymelek, Abdullah; Yildirim, Ömer; Demirtaş, Betül; Türker, Temel
It is very important to distinguish the reason of change in natural frequencies of structures either caused by a possible damage or environmental conditions (temperature and humidity). In this study, the changes in the dynamic properties of masonry and reinforced concrete minarets under environmental effects, such as temperature and humidity, were investigated. The masonry minarets of İskenderpaşa, Hacı Kasım, and Tavanlı Mosques and the reinforced concrete minarets of Karadeniz Technical University, Dilaveroğlu and Papatya Mosques in Trabzon were monitored by ambient vibration test method, and the relationship between natural frequencies and temperature and humidity was tried to be determined. For this purpose, the natural frequencies of these minarets were measured at certain intervals under different temperature and humidity conditions over a period of approximately 6 months. The vibration measurement system which was developed by our research team was used in the measurements. From the data collected by these measurements, the variation intervals of the natural frequencies (the smallest and the highest values), the percentages of change and their relations with temperature and humidity were revealed. This relationship was determined using linear–non-linear simple and multiple regression analyses. From this study, it was found that the natural frequencies change under environmental effects, such as temperature and humidity, and this rate of change was approximately 7%. There was moderate correlation in Tavanlı, Dilaveroğlu, and Papatya Minarets, and strong correlation in Hacı Kasım Minaret.
AtıfScopus16WoS17OpenAlex16İncele - MakaleAçık Erişim2024Scopus SJRQ3Unveiling the significance of Gremlin-1 as a novel biomarker for enhanced severity prediction in COVID-19 patients
Celik, Muhammet; Tekin, Erdal; Koçak, Mehmet Nuri; Uzunçakmak, Sevgi Karabulut; Bayraktar, Mustafa
Gremlin-1 is associated with lung disease and plays a role in the initiation and progression of pulmonary fibrosis. This suggests that Gremlin-1 may be associated with lung involvement in COVID-19 and poor clinical outcomes and warrants further investigation. This prospective, cross-sectional, single-blind study was the first to investigate Gremlin-1 levels in COVID-19 patients and whether Gremlin-1 levels could be used to predict and guide clinical follow-up in outpatients and inpatients. In this context, serum Gremlin-1 levels were measured and compared in 2 groups of patients who were diagnosed as positive for COVID-19 by RT-PCR and were followed up as outpatients (n = 28) or required hospitalization (n = 30). The median Gremlin-1 values were statistically significantly different between outpatients and intensive care unit patients (0.367 ng/mL [IQR = 0.377], 1.858 ng/mL [IQR = 2.245], respectively) (P < .0001). The area under the ROC curve value to determine the discriminative power of Gremlin-1 was found to be 0.772 (95% CI: 0.672-0.871; P < .0001), and the cutoff value of Gremlin-1 to discriminate between outpatients and hospitalized patients was found to be 1.242 ng/mL with 66.7% sensitivity and 67.2% specificity. Serum Gremlin-1 level is an important biomarker that can be used as a clinical decision-making tool for COVID-19 positive patients.
AtıfScopus2WoS2OpenAlex3İncele - MakaleAçık Erişim2024Scopus SJRQ1Thermal and energy analysis of a novel solar updraft tower design with divergent chimney and convergent collector concept: CFD analysis with experimental validation
Cuce, Pinar Mert; Saxena, Abhishek; Cuce, Erdem; Kontoleon, Karolos J.; Oztekin, Erman K.; Shaik, Saboor; Guo, Shaopeng
The fact that energy sources are heavily dependent on fossil fuels increases the need for alternative energy day by day. Solar energy is the most popular alternative energy source with massive potential. Solar chimney power plants (SCPP) are one of the systems of interest based on solar energy. SCPP systems are rare systems that can provide 24-hour power output. Their performance has been the subject of constant research since the first pilot plant in Manzanares. Design is crucial for performance figures of SCPPs, and the limitation of climatic parameters causes the system to be approached with different designs. This study makes a 3D CFD model by combining the divergent chimney and convergent collector structure based on the first pilot plant. The solar ray tracing algorithm and the RNG k-e turbulence model are applied and the model equations are solved under dynamic conditions with the reliable software ANSYS FLUENT. After the mesh-independent solution of the model is complete, it is validated with experimental data. The two cases are compared for solar radiation of 1000 W/m2 and environmental temperature of 293 K. A power output of 50.51 kW is achieved for standard pilot sizing. With the new model, the power output rises to 146.34 kW. It is seen that the divergent chimney and convergent collector affect the airflow in the system, increasing the maximum air velocity to 19.363 m/s. In parallel with the experimental data, it is seen that the temperature on the ground exceeds 360 K in the CFD results.
AtıfScopus17WoS12OpenAlex14İncele - MakaleYalnız künye2024Scopus SJRQ2A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine
Kaya, Alican; Ceylan, Aslı F.; Kavutcu, Mustafa; Santamaria, Abel; Šoltésová Prnová, Marta; Stefek, Milan; Karasu, Çimen
Inhibiting aldose reductase (ALR2, AR) as well as maintaining a concomitant antioxidant (AO) activity via dual-acting agents may be a rational approach to prevent cellular glucotoxicity and at least delay the progression of diabetes mellitus (DM). This study was aimed at evaluating the dual-acting AR inhibitor (ARI) cemtirestat (CMTI) on tissue oxidative stress (OS) and carbonyl stress (CS) biomarkers in rats exposed to fructose alone (F) or fructose plus streptozotocin (D; type-2 diabetic). D and F rats were either untreated or treated daily with low- or high-dose CMTI, ARI drug epalrestat (EPA) or antioxidant stobadine (STB) for 14 weeks. Malondialdehyde (MDA), glutathione S-transferase (GST), nitric oxide synthase (NOS), and catalase (CAT) were increased in the sciatic nerve of F and D. These increases were attenuated by low doses of CMTI and STB in D, but exacerbated by low-dose EPA and high-dose CMTI in F. STB and CMTI and to a lesser extent EPA improved MDA, protein-carbonyl, GST and CAT in the hearts and lungs of F and D. CMTI and STB were more effective than EPA in improving the increased MDA and protein-carbonyl levels in the kidneys of F and especially D. CMTI ameliorated renal GST inhibition in D. In the lungs, hearts, and kidneys of F and D, the GSH to GSSG ratio decreased and caspase-3 activity increased, but partially resolved with treatments. In conclusion, CMTI with ARI/AO activity may be advantageous in overcoming OS, CS, and their undesirable consequences, with low dose efficacy and limited toxicity, compared to ARI or antioxidant alone.
AtıfScopus5WoS6OpenAlex5İncele - MakaleAçık Erişim2024Scopus SJRQ3The aroma profile of butter produceusing different starter cultures; [Aromatski profil maslaca proizvedenih korištenjem različitih starter kultura]
Şengül, Mustafa; Akgül, Halil İbrahim; Ürkek, Bayram
The aroma of fermented dairy products is greatly influenced by starter cultures and by the lactic acid bacteria strains that are used as starter cultures. Experimental butter samples were produced using no starter culture, by a commercial starter culture (Lactococcus lactis subsp. lactis, Lactococcus lactis subsp. cremoris, Lactococcus lactis subsp. lactis biovar. diacetylactis, Leuconostoc mesenteroides), by a prepared bacteria mix (Lactococcus lactis subsp. lactis EM1, Lactococcus lactis subsp. cremoris EM28, Lactococcus lactis subsp. lactis biovar. diacetylactis G49, Leuconostoc mesenteroides B3), and by a prepared bacteria mix fortified with Lactobacillus rhamnosus B19 (L. rhamnosus B19). The aroma profile of the butter samples was investigated using a gas chromatography mass spectometry method (GC-MS). A total of 92 components were determined in the butter samples, including acids (12), alcohols (20), aldehydes (9), alkanes (6), esters (8), ketones (19) and several other aroma compounds (18). The sample containing the prepared starter culture had the most detectable aroma components, while the lowest number of aromatic components were found in the sample without a starter culture. 2,3-butanedione (diacetyl) was not detected in the sample without a starter culture. 2-Butanone 3-hydroxy-(acetoin) content was the highest in the sample containing the commercial starter culture and the lowest in the sample without a starter culture.
AtıfScopus6WoS3OpenAlex6İncele - MakaleAçık Erişim2024Scopus SJRQ2Determinants of Ecological Footprint: A Quantile Regression Approach
Özcan, Kübra Akyol
Through the examination of the ecological consequences of human actions, policymakers are able to distinguish certain areas in which resource use can be increased and the generation of waste diminished. This study examines the effects of foreign direct investment, gross domestic product, industrialization, renewable energy consumption, and urban population on the ecological footprints in 131 countries between 1997 and 2020. The objective of this study is to establish a thorough understanding of the relationship between these variables and ecological footprints while considering temporal changes from economic and environmental aspects. The analysis of a substantial dataset encompassing many countries aims to uncover recurring patterns and trends that can provide valuable information for the formulation of policies and strategies pertaining to sustainable development on a global level. The study fills a significant gap in the knowledge on the ecological impact of different variables, providing a nuanced understanding of the interdependencies among these factors, thus guiding sustainable development strategies, and promoting global sustainability. The study utilizes quantile regression analysis, a nonparametric estimator, to estimate consistent coefficients. The statistical analysis reveals that FDI, urbanization, and GDP have statistically significant and positive effects on ecological footprints. Industrialization and renewable energy consumption show significant and negative relationships with ecological footprints. The findings of this study contribute to the understanding of the relationships among these variables and provide insight to inform policy and decision-making efforts focused on reducing ecological consequences and advancing sustainable development goals.
AtıfScopus16WoS13OpenAlex21İncele