Bayburt ÜniversitesiBayburt ÜniversitesiAçık Erişim Arşivi · RDL Open

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  • MakaleAçık Erişim2025Scopus SJRQ1
    Experiences of adults with type 2 diabetes mellitus with low socioeconomic status: a qualitative study

    Semerci Çakmak, Vahide; Sönmez Sari, Ebru; Çetinkaya Özdemir, Serap

    Background: Adults with diabetes encounter various challenges related to managing their condition. In this study, we explored the experiences of adults with type 2 diabetes mellitus with low socioeconomic status in Türkiye. Methods: This study was conducted as a phenomenological qualitative research. The purposive sampling method was used to select adults with type 2 diabetes. Data saturation was achieved with 20 patients. The data were collected through a demographic information form and a semi-structured questionnaire. The participants were interviewed by phone. The interviews were conducted in a quiet environment where the participants could respond comfortably. During the data analysis process, the content analysis approach suggested by Graneheim and Lundman (2004) was used. This method involves identifying meaningful units within the text, coding these units, and developing sub-themes and main themes. The MAXQDA 20 software was used for data management. Results: The participants were between 41 and 71 years old. Four main themes and ten subthemes were identified in the analysis. Themes: The identified themes included difficulties with dietary management of diabetes, individual difficulties, difficulties with self-management in diabetes, and coping strategies. According to Theme 1, it was observed that the participants experienced difficulties in managing nutrition in diabetes due to the economic aspect of diet and the inability to adapt to the diet. According to Theme 2, it was observed that the participants faced physical, psychological, and social difficulties. According to Theme 3, it was observed that the participants faced difficulties related to diabetes self-management, including blood glucose monitoring, insulin injection administration, and maintaining glycemic control.” According to Theme 4, it was observed that the participants attempted to cope with diabetes-related difficulties through healthy lifestyle habits and family support. Conclusion: Our findings indicate that adults with type 2 diabetes in low socioeconomic status face challenges related to biopsychosocial factors, nutrition, and diabetes self-management. However, these individuals managed their difficulties by adopting healthy lifestyle behaviors and relying on family support. The challenges faced by adults with diabetes may be alleviated through awareness training on dietary management and glycemic control.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 10 · Eşitsizliklerin Azaltılması
    AtıfScopus8WoS6OpenAlex9
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2025Scopus SJRQ2
    Investigation of the Structural and Corrosion Properties of Duplex Surface Treated AZ31 Magnesium Alloy

    Durna, İdris; Çatar, Recep; Altun, Hikmet

    The AZ31 alloy was first completely coated with pure aluminum in this study using the electric arc spray coating method. Then, considering the existing benefits of the micro-arc oxidation process (MAO), a ceramic oxide coating was formed by applying MAO to the Al-coated surface. Thus, a duplex coating was obtained on the base material. The structural properties of both the Al-coated samples and the duplex coatings obtained after the MAO process were investigated by scanning electron microscopy, energy-dispersive x-ray analysis (EDS), and x-ray diffraction devices. The electrochemical behavior of the coatings was carried out in a 3.5 wt.% NaCl solution. The samples were polarized from the potential value − 0.2 V below the corrosion potential to the maximum value of 2 V at a scanning rate of 1 mV/s, and potentiodynamic polarization curves were recorded. According to the electrochemical experiments, Al coatings and duplex coatings improved the corrosion resistance of AZ31 alloy. The corrosion current density values ​​were 298.23 µA/cm2 for the base material, 0.415 µA/cm2 for the Al coating, and 0.014 µA/cm2 for the duplex coating, respectively. The best corrosion resistance among all samples was obtained in duplex-coated samples obtained by MAO. Due to their low corrosion resistance, magnesium alloys are restricted in many areas, especially aviation, automotive, and biomedical. Therefore, this study aimed to improve the corrosion resistance of AZ31 magnesium alloy.

    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2025Scopus SJRQ1
    Imagery and motivation in performance sports: a psychological study on weightlifters

    Aksoy, Ebu Bekir Sıddık; Ceyhan, Mehmet Ali

    Background: This study investigates the relationship between imagery use and motivation among weightlifters, focusing on how demographic factors like gender, education level, and national status influence these aspects. Imagery, a mental strategy used to achieve goals and motivation, an intrinsic driving force, is explored within weightlifting. Despite research linking mental strategies to performance, studies targeting weightlifters still need to be expanded. This study examines how imagery impacts this group’s motivation levels and technical performance. Methods: The study included 347 licensed athletes participating in the 2022 Turkish Individual Junior and U-23 Weightlifting Championship in Van. Data were collected online using the “Personal Information Form,” the “Sport Imagery Questionnaire,” and the “Sport Motivation Scale.” Analyses were conducted with SPSS, assessing normality through skewness and kurtosis. Parametric tests, such as t-tests and one-way ANOVA, were applied for group comparisons. At the same time, Pearson’s Correlation Coefficient was used to explore relationships between continuous variables, including age, years of experience, and competition weight category. Results: A significant positive correlation was found between imagery use and motivation, particularly in the Cognitive Imagery (CI), Motivational Specific Imagery (MSI), and Motivational General-Mastery (MGM) subdimensions. Education level significantly influenced imagery use and motivation, with higher levels linked to better mental training and increased motivation. Although gender did not significantly affect these factors, female athletes displayed more robust emotional responses, enhancing their ability to use positive emotions effectively. Age and sports experience were also positively associated with effective imagery use, indicating that experienced athletes leverage mental strategies more proficiently. Conclusions: The findings emphasize imagery as a vital tool for enhancing motivation and performance in weightlifters. Athletes with higher education levels and more experience benefit more from mental training. Future research should broaden its scope to include diverse sports and age groups, while longitudinal studies can provide deeper insights into the evolution of imagery and motivation over time.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfOpenAlex2
    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2025Scopus SJRQ1
    Multi-input hybrid face presentation attack detection method based on simplified Xception and channel attention mechanism

    Günay Yılmaz, Asuman; Turhal, Uğur; Nabiyev, Vasif

    Currently, biometric recognition systems, especially facial recognition systems, are frequently used for person authentication. Increasing facial image and video sharing on social media makes these systems vulnerable to attacks. For this reason, there is an increasing need for sensitive face presentation attack (FPA) detection systems. In this paper, a lightweight multi-input hybrid deep convolutional neural network model was proposed for FPA detection. For this purpose, a simplified version of the widely used Xception network was developed. This model was extended via squeeze and excitation blocks to weight the data in the feature encoding channels. In addition, a simple residual network architecture with attention blocks was designed. The FPA detection performances of these models were subsequently examined in cases where the input data consisted of the raw images or cropped facial images. According to the results, a deep learning architecture with three parallel connections was proposed. The raw images, cropped facial images, and face-weighted multi-color multi-level local binary pattern features were given as inputs to the proposed model. Therefore, a multi-input hybrid FPA detection model was created using both hand-crafted features and deep features. The proposed architecture has approximately 82% fewer parameters than the original Xception network does. The experimental results on the benchmark CASIA and REPLAY-ATTACK datasets demonstrate the model's effectiveness, achieving a 1.53% equal error rate (EER) on the CASIA dataset and 0.00% EER with a 0.07% half total error rate (HTER) on the REPLAY-ATTACK dataset. These results outperform many state-of-the-art methods while requiring significantly fewer computational resources, making the approach suitable for deployment in resource-constrained environments.

    AtıfScopus5WoS4OpenAlex2
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2025Scopus SJRQ1
    The effect of laughter yoga on disease acceptance, treatment adherence and comfort in hemodialysis patients: A randomized controlled study

    BAL, Betül; KÖROĞLU-KABA, Nagihan; ÖZTÜRK, Havva; KURT, Yeter; ÖZSABAN, Aysel

    The aim of this study was to determine the effect of laughter yoga on hemodialysis patients' disease acceptance, treatment adherence and comfort levels. This randomized controlled study was conducted with 42 patients (experimental group=21, control group=21) who were treated in the hemodialysis unit. Hemodialysis patients in the experimental group received 12 sessions of laughter yoga for four weeks, three days a week. Data were collected using Patient Information Form, Disease Acceptance Scale, End-Stage Renal Disease Adherence Questionnaire, and Hemodialysis Comfort Scale. A significant difference was found between the disease acceptance scale (t(41) = 4.39, p < 0.001, d = 1.364), end-stage renal failure adaptation scale (t(41) = 2.69, p = 0.010, d = 0.830) and hemodialysis comfort scale (t(41) = 5.58, p = 0.010, d = 1.710) of hemodialysis patients who underwent laughter yoga. In addition for the Disease Acceptance Scale, the SD of the pre-test scores was 7.51. Accordingly, the MCID thresholds were calculated as 3.75 (0.5 SD), 3.11 (1 SEM), and 6.09 (1.96 SEM). For the End-Stage Renal Disease Adherence Questionnaire, the SD was 178.79, and the MCID was calculated as 89.40 (0.5 SD), 63.47 (1 SEM), and 124.39 (1.96 SEM). For the Hemodialysis Comfort Scale, the SD was 6.43, resulting in MCID estimates of 3.21 (0.5 SD), 2.01 (1 SEM), and 3.94 (1.96 SEM). Laughter yoga practiced during hemodialysis increased acceptance of the disease, adherence to treatment, and comfort (p < 0.05). In contrast, no statistically significant difference was found in the control group (p > 0.05). Increasing hemodialysis patients' acceptance of the disease, adherence to treatment, and comfort levels ensure the successful continuation of the disease management process. The practice of laughter yoga in clinics during hemodialysis sessions is recommended to increase disease acceptance, adherence to treatment and comfort levels.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus1WoS1OpenAlex1
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2025Scopus SJRQ2
    Evaluation of Fe Content on the Fluidity of A356 Aluminum Alloy by New Fluidity Index

    Durmuş, Melek; Dispinar, Derya; Gavgali, Mehmet; Uslu, Emin; Çolak, Murat

    Elements that are deliberately added to aluminum alloys or are incorporated into the alloy later depending on the production process affect the final product properties. In addition, liquid metal cleaning is important in minimizing undesirable elements. Considering the production process, one of the most harmful impurities that is likely to pass into the alloy via diffusion for aluminum is the element, Fe. It is known that this is due to the fact that although Fe is highly soluble in liquid aluminum and its alloys, it has very little solubility in solids. Depending on the Fe content, mechanical properties, porosity and fluidity properties are affected in aluminum alloys. In this study, stainless and carbon steel rods were dipped into the melt at 700 °C and 750 °C for 1, 2 and 5 h. Castings were performed before and after degassing. Four-channel fluidity mold with different section thickness was used in the trials. Additionally, microstructure characterization was performed under varying casting conditions. Fluidity Index was proposed which is a single value measured from all fluidity values in different sections. When the results were examined, it was determined that the diffusion material, holding time, casting temperature and liquid metal cleanliness had an effect on the fluidity. Due to the increase in diffusion time, a decrease in fluidity was observed in both carbon steel and stainless steel. It was found that fluidity was significantly reduced when using stainless steel.

    AtıfScopus14WoS14OpenAlex15
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2025Scopus SJRQ3
    Evaluation of miR-130b-3p and miR-375 levels and telomere length with telomerase activity in prostate cancer

    Karadağ, Abdullah; Dirican, Ebubekir; Özmerdiven, Çağdaş Gökhun; Özen, Ata; Ayan, Semih; Kabadere, Selda

    Prostate cancer (PC) is the most frequent cancer in males, as well as the second highest cause of cancer-related deaths in men. Differences in expression levels of miRNAs were linked with prostat cancer pathogenesis. qPCR was used to evaluate the expression of miR-130b-3p and miR-375 in Benign Prostate Hyperplasia (BPH (n = 20) and PC (n = 22, pre- and post-operative) patients plasma. Relative telomere lengths (RLTs) in genomic DNA isolated from plasma were measured with qPCR, and telomerase activity analyzed by the ELISA method. PSA levels of PC patients were greater than of BPH patients (p = 0.0473). miR-130b-3p and miR-375 levels were significantly lower in pre-operative specimens of PC patients according to BPH (p = 0,0362, p = 0.0168, respectively). Similarly, post-operative miR-375 levels were lower in PC patients than in BPH patients (p = 0.1866). BPH patients had shorter RTLs than PC patients in both pre- (p=0.0438) and post-operative (p=0.0297) specimens. Telomerase activity was higher in PC patients than BPH(p = 0.0129). Interestingly, telomerase activity was further increased after surgery (p = 0.0003). We aim to identify the levels of miR-130b-3p and miR-375 expression and their relationship with telomerase activity in PC patients. Our data suggest that miRNAs and telomere length (TL) with telomerase activity may play a role in regulating prostate tumorgenesis and may be used as biomarkers for PC diagnosis.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2025Scopus SJRQ1
    Seismic resilience of existing RC dual-system buildings during the 2023 Kahramanmaraş earthquakes: a case study

    Tonyali, Zeliha; Kiral, Adnan; Ergun, Mustafa; Garcia, Reyes

    This study investigates the seismic resilience of an existing reinforced concrete (RC) dual-system during the 2023 Kahramanmaraş earthquakes. The shear wall-frame dual building was designed according to the Turkish guidelines (TEC 2007) and experienced negligible damage during the earthquakes, whereas all neighboring buildings collapsed. The case study building is modeled in SAP2000® adopting a lumped plasticity approach. The 3D building model was subsequently subjected to pushover and nonlinear time-history analyses (NTHAs) using real ground motions recorded during the first and strongest mainshock of the Kahramanmaraş earthquakes ((Formula presented.) = 7.7 Pazarcik earthquake). The results from the NTHAs indicate that the maximum inter-story drift (IDR) ratios on all floors of the case study building remained below the Immediate Occupancy performance level (IDR = 1.0%). Moreover, the dual-system building designed with TEC 2007 survived the earthquakes without damage, even when the design earthquake scenarios exceeded those considered in the new and more stringent TBEC 2018 (i.e. a 475 return period). The limited damage experienced by the RC dual-system building can be largely attributed to its high wall index (WI = 1.5% and 1.84%) and high average lateral stiffness index (H/T ≥45.3), which are above the minimum values (ρ = 0.6% and H/T ≥45) suggested in previous research. This study also highlights the critical importance of site-specific ground motion selection, particularly in the context of Hatay province, where the seismic demands exhibited significant variability and intensity. This study contributes to a better understanding of the resilience of RC shear wall-frame buildings in seismic zones.

    • SDG 9 · Sanayi, Yenilikçilik ve Altyapı
    • SDG 11 · Sürdürülebilir Şehirler ve Topluluklar
    AtıfScopus13WoS12OpenAlex16
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2025Scopus SJRQ3
    Application of the entropy based COPRAS model in determining the most appropriate irrigation systems for agricultural enterprises producing maize

    Ulay, Göksel; Peker, Hüseyin; Ayata, Ümit

    Synthetic-based furniture varnish (colorless and glossy) was applied in two coats using a brush to the following wood types: lemon (Citrus limon (L.) Burm.), black pine (Pinus nigra Arnold), kotibé (Nesogordonia papaverifera), iroko (Milicia excelsa Welw. C.C. Berg), and loquat (Eriobotrya japonica Lindl.). The color parameters [b*, ho, L*, a*, and C*, ∆a*, ∆L*, ∆C*, ∆H*, ∆b*, and ∆E*] of the varnished and unvarnished surfaces were compared. The analysis of variance results for all color parameters revealed significant effects for wood type, varnish application, and their interaction. When the ∆E* values derived from color formulas were sorted from the lowest to the highest, they were ordered as follows: lemon, black pine, kotibé, loquat, and iroko. After varnish application, decreases in L* values were observed across all wood types, while increases in b* and C* values were detected. In black pine wood, the a* and ho values increased. Additionally, for iroko, loquat, and kotibé woods, there was an increase in the a* parameter, while ho values decreased for these wood types. Overall, the varnish application resulted in color changes in the wood materials.

    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2025Scopus SJRQ1
    Anticancer (cytotoxic, anticlonogenic, antimetastatic, immunomodulatory actions) properties of 3,5-dibromosalicylaldehyde against glioblastoma cells and DFT analyses (FT-IR, Raman, NMR, UV) as well as a molecular docking study

    Karakaş Sarıkaya, Ebru; Pehlivanoğlu, Suray; Türkmen, Merve Özcan; Ekincioğlu, Yavuz; Kostak, Feyza; Çelik, Sultan; Dereli, Ömer

    Background Information: The primary objectives of this study were to characterize 3,5-dibromosalicylaldehyde (3,5-DBSA) and, investigate its antiproliferative, antimetastatic, cytotoxic, and immunoregulatory properties. NMR, Raman, UV, and FT-IR spectroscopies were used to characterize 3,5-DBSA. Potential conformations of 3,5-DBSA were evaluated using Spartan's MMFF method. Geometry optimization calculations using Gaussian software calculated conformation energy values. Results: Subsequently, Raman, FT-IR, UV (ethanol) and NMR (DMSO) parameters were calculated. The experimental spectrum was compared to theoretical spectroscopic data. The present investigation investigated 3,5-DBSA's anticancer properties; therefore, docking was done once the stable structure had been identified. Conclusion: Identifying stable structure is crucial to molecular docking studies. In order to identify the mechanism by which 3,5-DBSA binds to PI3K as a therapeutic target, molecular docking was utilized. This work is the first to show that 3,5-DBSA is cytotoxic, anticlonogenic, antimetastatic, and immunomodulatory in glioblastoma cell line U87MG compared to healthy fibroblast L929 cells. Cytotoxicity and anti-clonogenicity studies investigated 3,5-DBSA's antiproliferative activities, whereas wound healing assays assessed cell migration. The immunomodulatory effects of 3,5-DBSA in glioblastoma were assessed by measuring Netrin-1 and IL-6 protein levels. According to our findings, 3,5-DBSA may treat glioblastoma. Significance: This work analyzes 3,5-DBSA's conformational search, characterization, molecular docking, and structural and anticancer properties.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2025Scopus SJRQ4
    Tunable optoelectronic performance of ZnO-Coated TiO2 nanowires for enhanced UV photodetection

    Sarac, M.F.; Solakyildirim, T.; Teber, A.

    In this study, vertically aligned TiO2 nanowires (NWs) were fabricated on titanium (Ti) foil via thermal oxidation and subsequently coated with zinc oxide (ZnO) using zinc acetate solutions of 25, 50, and 100 mM concentrations. Structural and optoelectronic properties were systematically investigated using SEM, XRD, XPS, PL, UV-Vis, and I-V analyses. SEM results confirmed a progressive ZnO surface coverage, with complete encapsulation observed at 100 mM. EDS analysis revealed a Zn content increase from 0.81 wt.% (25 mM) to 8.43 wt.% (100 mM), accompanied by a decrease in Ti content from 70.78 wt.% to 49.02 wt.%. XRD patterns showed distinct ZnO peaks for coated samples, while XPS confirmed Zn2+ and Ti4+ states with minimal interdiffusion. Optical bandgap values increased slightly with ZnO concentration: 3.04 eV (pure TiO2), 3.06 eV (25 mM), 3.05 eV (50 mM), and 3.11 eV (100 mM), attributed to enhanced crystallinity and heterojunction formation. PL spectra showed increasing green luminescence (∼520 nm) with ZnO content, indicating rising defect-related recombination. Electrical measurements showed a sharp rise in photocurrent from 3.67 × 10−6 A (pure TiO2) to 4.74 × 10−4 A (100 mM). Correspondingly, responsivity (R) increased from 0.020 to 2.168 mA/W and detectivity (D*) from 8.5 × 108to 7.56 × 109 Jones. These results demonstrate that ZnO coating substantially enhances light absorption, charge separation, and carrier transport properties of TiO2 NWs. The optimized 100 mM ZnO-TiO2 heterostructure offers high-performance UV photodetection potential for environmental sensing, wearable optoelectronics, and aerospace technologies.

    AtıfOpenAlex1
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2025Scopus SJRQ3
    Examining the Criteria Affecting Corporate Social Responsibility in Businesses from the Consumer Perspective Using the Pythagorean Fuzzy Entropy Technique; [İşletmelerde Kurumsal Sosyal Sorumluluğu Etkileyen Kriterlerin Pisagor Bulanık Entropi Tekniğiyle Tüketici Perspektifinden İncelenmesi]

    Keskin, Abdulkadir; Kiraçli-Leblebicioğlu, Nilüfer; Keskin, Abdurrahman; Leblebicioğlu, Burak

    Corporate social responsibility (CSR) serves as a self-regulation mechanism for businesses and a framework for consumers to evaluate companies. Carroll's (1991) CSR pyramid categorises these responsibilities, which can differ depending on cultural and economic contexts. This study examines Corporate Social Responsibility (CSR) in the context of Carroll's pyramid from the perspective of Turkish consumers, based on expert interviews analysed using the “Pythagorean Fuzzy Entropy” method. The results reveal that Turkish consumers prioritise businesses' “economic” responsibilities the most, followed by “philanthropic” responsibilities. “Ethical” responsibilities are ranked slightly lower, with “legal” responsibilities considered the least important in this context.

    AtıfScopus1OpenAlex2TR Dizin1
    ScopusWeb of ScienceTR Dizinİncele
  • MakaleAçık Erişim2025Scopus SJRQ2
    Determining errors in force measurements for colloids close to contact

    Yücel, Harun

    Due to diffraction patterns in light microscopy, the overlapping of colloid images introduces minor errors in determining particle positions, which affecting the accuracy of observing interactions between colloids near contact. This study quantitatively investigates the errors arising from the overlapping effect in force measurements between two closely positioned colloids using digital video microscopy (DVM). For this aim, computer simulations were conducted to obtain the positions of two optically trapped colloids interacting based on a force model and particle images were generated as a time series using experimental particle intensity profiles for two different particle sizes. These generated images were analyzed using tracking algorithms from the literature and the interaction forces were extracted and compared with theoretical force values. The results demonstrated that diffraction patterns significantly influence the accuracy of particle position detection and interaction force calculations. Large diffraction patterns and intensity fluctuations in an image introduce significant errors. However, these errors can become significantly smaller in the presence of large forces and may therefore be considered negligible.

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  • MakaleAçık Erişim2025Scopus SJRQ2
    The Effect of Health Literacy Level of Caregivers of Individuals With Diabetes on Care Activities and Supportive Behaviours

    Semerci Çakmak, Vahide; Akeren, Zahide; Sönmez Sarı, Ebru; Kalyoncuo, Servet

    Background: To determine the effect of the health literacy levels of caregivers of individuals with T2DM on caregiving activities and supportive behaviours. Methods: Cross sectional study. The sample for the study comprised of people who provided care for 442 individuals who were diagnosed with diabetes. The data were collected using the Personal Information Form, HLS-14 and D-CASS. Descriptive statistics, Independent samples t test, One-Way ANOVA and multiple linear regression analysis were used to analyse the data. Results: According to the results of the multiple linear regression analysis, the model was found to be statistically significant, and the variables that were incorporated into the model were able to explain 68.1% of the variance. Among the variables included in the model, HLS-14, educational status, employment status, income status and diabetes-related education were found to affect the care activities and supportive behaviours of caregivers of individuals with diabetes. Conclusion: In the research, it was determined that care activities and supportive behaviours were higher in those with higher levels of HL, higher levels of education, those who were not employed, those with higher income levels, and those who received education about diabetes. Nurses should develop training programmes to increase the HL levels of caregivers.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus2WoS2OpenAlex3
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2025Scopus SJRQ1
    Metabolic syndrome index measurement tool (MSI): scale development, reliability and validity study

    Akeren, Zahide; Apaydın, Emine

    Aim: Identifying the risks of metabolic syndrome (MetS) can lead to early targeted interventions and thus contribute to improved quality of life by reducing the risk of developing MetS, diabetes or heart disease in the future. We aimed to develop a valid and reliable measurement tool to measure the MetS risk of the population. Materials and methods: In the methodological study, an item pool was created by reviewing the literature. Pre-application was performed after the weighting of the items whose content validity was ensured by taking expert opinions. Data were collected from 43 patients with MetS from a state hospital affiliated to the Ministry of Health and 405 individuals without MetS from the community, from a total of 448 individuals using the Individual Information Form, Finnish Diabetes Risk Scale (FINDRISC) and Metabolic Syndrome Index (MSI). The data obtained were evaluated using SPSS 22.0 and MedCalc 19.1 statistical programmes. Scale discrimination was analyzed by independent samples t-test between the upper and lower 27% groups. The cut-off point of the scale score in predicting the diagnosis of MetS was tested by ROC analysis. Correlation analysis was performed with the parallel form for criterion validity. Results: As a result of the ROC analysis, a perfectly compatible scale with a sensitivity of 100%, a specificity of 85.43% and a cut-off score of 48 was obtained. When the correlation analyses between MSI and FINDRISC scores were examined for criterion validity, a positive moderate (r = 0.632, p < 0.001) correlation was found between FINDRISC and MSI. When the discrimination of the scale was analysed, it was found that there was a significant difference between the lower 27% and upper 27% groups (p < 0.05) and it was revealed that the MSI made sensitive measurements to discriminate. Conclusions: The MSI scale is a valid and reliable tool for early detection of MetS risk.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus2WoS2OpenAlex2
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2025Scopus SJRQ2
    Detailed investigation of the spectroscopic features of nicardipine hydrochloride using experimental and quantum chemical methods

    Can, Sumeyra; Cinar, Mehmet; Baris, Ozlem

    Context: The structural and spectroscopic properties of drug groups can be determined using spectroscopic techniques and quantum chemical calculations. In this study, the structural and spectroscopic properties of nicardipine, a potent calcium channel blocker belonging to the dihydropyridine drug group, were investigated. For this purpose, FT-IR, Raman, NMR, and UV–Vis spectra of nicardipine hydrochloride were recorded. The ground state geometry optimization performed under vacuum conditions showed excellent agreement with X-ray diffraction (XRD) data, with root-mean-square deviations of bond lengths and bond angles calculated as 0.017 Å and 2.2°, respectively. Vibrational spectrum analysis revealed all characteristic modes, and theoretical B3LYP predictions largely agreed with experimental data. NMR spectra recorded in chloroform solvent confirmed the molecular structure of nicardipine. A comparison with previously reported data revealed significant differences in the proton NMR results, while the carbon NMR data showed consistency. The gauge-invariant atomic orbital (GIAO) method, commonly used for NMR spectrum prediction, yielded results within an acceptable error range despite minor inconsistencies arising from differences between experimental and computational conditions. In the UV–Vis spectrum of nicardipine HCl, an absorption peak corresponding to π-π* excitation was observed at 238 nm. Method: The geometric optimizations and vibration spectra of the nicardipine drug molecule were performed using the Gaussian 09 program with the B3LYP functional and the 6–311 + + G(d,p) basis set. Visualizations were performed using the GaussView 5.0 interface program. NMR spectra were recorded in chloroform solvent using the GIAO method. Molecular electrostatic potential (MEP) maps and Mulliken atomic charges were analyzed to gain deeper insight into the electronic properties.

    AtıfScopus1WoS1OpenAlex1
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  • MakaleAçık Erişim2025Scopus SJRQ2
    Investigation of the Effects of Filling Speed, Casting Temperature and Metallurgical Quality on Fluidity of Lamellar Graphite Cast Iron at Different Section Thicknesses

    Köse, Sami; Çolak, Murat; Şüküroğlu, Ebru Emine

    In this study, the fluidity properties of the alloy were investigated at different casting temperatures, different section thicknesses, and varying casting parameters of lamellar graphite cast iron materials. To achieve our goal, we utilized sand molds that were created with specific parameters including pouring temperature, metallurgical quality, section thickness, and fluidity test model. These molds were used for casting. Thus, the effect of fluidity properties in changing casting conditions and liquid metal advance distances at determined section thicknesses was investigated. Modeling was carried out with FlowCast casting simulation software by determining the liquid metal advance distance depending on the section thickness in the castings made in sand molds under changing casting conditions. The fluidity and advance distance of the liquid metal was determined comparatively with experimental and modeling techniques under the changing casting conditions in the parameters determined in this study. When the outcomes were examined; it was observed that different liquid metal advance distances occur at different cross-section thicknesses depending on the changing conditions.

    AtıfScopus8WoS8OpenAlex7
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2025Scopus SJRQ2
    Semi-analytical analysis of orthotropic-isotropic contact in layered media with consideration of body forces

    Öner, Erdal; Oktay, Mine Gül

    Contact mechanics is a key field that involves theoretical, computational, and experimental methods essential for tribology and designing components across various industries. It plays a crucial role in solving boundary value problems in civil engineering, mechanical engineering, and medicine. This study investigates the continuous contact problem of an orthotropic layer positioned on an isotropic half-plane, utilizing a semi-analytical approach based on elasticity theory. The solution considers the body force generated within the orthotropic layer when subjected to frictionless loading by a rigid cylindrical punch. The research presents dimensionless results for key parameters, including contact length, contact stress, critical separation distance, and critical separation load, while examining the effects of different dimensionless variables and the characteristics of the orthotropic materials. The novelty of this study lies in its simultaneous analysis of isotropic and orthotropic material behavior in a contact mechanics problem, along with the incorporation of body forces—a combination that has not been previously explored for this specific geometry in the literature. The study offers a more comprehensive understanding of the contact mechanics involved by addressing the often-overlooked influence of body forces, which play a crucial role in stress distribution and material deformation, particularly in large-scale structures. This inclusion allows for more accurate predictions of material behavior in real-world engineering applications where gravitational loads are significant factors.

    AtıfScopus4WoS4OpenAlex4
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2025Scopus SJRQ1
    Design, synthesis, and inhibition of α-glucosidase by novel L-phenylalanine-derived hydrazones: Kinetic, molecular docking, and dynamics studies

    Kalay, Erbay; Adem, Şevki; Demir, Yeliz; Aslan, Osman Nuri; Şahin, Engin; Eyupoglu, Volkan; Rawat, Ravi; Çomaklı, Veysel

    In this paper, a series of novel hydrazones derived from L-phenyl alanine were synthesized in four steps and employed to inhibit α-glucosidase through kinetic studies, molecular docking, and molecular dynamics analyses. Among the synthesized compounds, 8, 15, and 16 exhibited the strongest inhibitory effects, with IC50 values of 31.08 μM, 24.15 μM, and 19.47 μM, respectively, surpassing the standard inhibitor acarbose (79.63 μM). Molecular docking studies revealed robust interactions, with compound 16 achieving the highest MolDock score of −176.316. Molecular dynamics simulations were conducted to evaluate the binding affinity of compound 16 to the isomaltase enzyme from Saccharomyces cerevisiae (3A4A). The most favorable docking pose was subjected to further analysis through MD simulations under dynamic conditions. The MMGBSA analysis of the simulation cluster indicated a strong binding affinity of approximately −43.06 kcal/mol, highlighting the compound's potential for modulating α-glucosidase activity. These results underscore the potential of bromine and hydroxyl-substituted hydrazones to modulate isomaltase activity, with therapeutic implications for hyperglycemia and obesity management.

    AtıfScopus12WoS12OpenAlex16
    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2025Scopus SJRQ3
    Electronic structure and adsorption behavior of 2PANI with selected gases: A DFT approach

    Ekincioglu, Yavuz

    This study examines the adsorption properties of C2H4, F2, HCl, and H2S gases on 2PANI using density functional theory (B3LYP/6-311++G(d,p)). Adsorption energies follow the order: 2PANI-HCl > 2PANI-H2S > 2PANI-C2H4 > 2PANI-F2 including the BSSE corrections. Geometry optimizations and topological analyses (electrostatic potential, localized orbital locator and electron localization function) were performed using Multiwfn software. Mulliken charge analysis assessed the sensing potential of 2PANI for each gas. Time-dependent DFT was used to analyze molecular orbitals, reactivity indices, density of states, and UV-Vis spectra, revealing red or blue shifts depending on the gas type. The results confirm that C2H4, F2, HCl, and H2S can be physically adsorbed onto 2PANI. The recovery time and conductivity were evaluated to determine gas sensitivity performance.

    AtıfScopus1WoS1OpenAlex1
    ScopusWeb of Scienceİncele