Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Dertli, Enes(117)
- Kaya, Yunus(51)
- Şahin, Engin(48)
- İspirli, Hümeyra(47)
- Özen, Soner(46)
- Şenay, Volkan(45)
- Pat, Suat(44)
- Can, Zehra(39)
- Bayraktar, Bülent(37)
- Bayram, Sinan(37)
- Korkmaz, Şadan(36)
- Cuce, Erdem(35)
- Ecem Bayram, Nesrin(33)
- Kutlu, Naciye(33)
- Yilmaz, Mustafa Tahsin(32)
- Artar, Musa(31)
- Ertugrul, Mehmet(30)
- Öner, Erdal(30)
- Ayata, Ümit(29)
- Hasar, Ugur Cem(29)
- Esmer, Yusuf(28)
- Mercan, Emin(27)
- Cuce, Pinar Mert(26)
- Özdemir, Akın(25)
- Çolak, Murat(24)
- Bayram, Ozkan(23)
- Kamiloğlu, Aybike(23)
- Sert, Durmuş(22)
- Ayazoglu, Rabil(21)
- Abdioglu, Murat(20)
- Bayram, Nesrin Ecem(20)
- Kadakal, Mahir(20)
- Kara, Yakup(20)
- Kizil, Hamit Emre(20)
- Tozlu, Alperen(20)
- Birinci, Ahmet(19)
- Gerçek, Yusuf Can(19)
- Battal, Fetullah(18)
- Dirican, Ebubekir(18)
- Ergün, Mustafa(18)
Yayınlar
- MakaleAçık Erişim2023Molecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalin
Güler, Halil Ibrahim; Kolaylı, Sevgi; Kara, Yakup; Birinci, Ceren; Can, Zehra
This study investigated that the acetylcholinesterase, urease enzyme inhibition and these enzymes molecular docking as well as antioxidant activity of commercially available amygdalin. While Amygdalin displayed effect anti-urease activity compared to acetohydroxamic acid but, anti-acetylcholine esterase activity a little ineffective compared to donepezil. The molecular docking was performed in order to check binding interactions between the amygdalin and the enzymes. DPPH and FRAP assays were preferred to determine the antioxidant activity. The antioxidant activity (3.39±0.33 µmol Fe2SO47H2O /g, SC50 18.74±0.72 mg/mL using the FRAP and DPPH assays, respectively. Amygdalin's in vitro and in vivo studies are needed for demonstrated that is a therapeutic agent for the treatment of various diseases.
- MakaleAçık Erişim2023Silver nanoparticle synthesis by biogenic reduction method and investigation of antimicrobial, antibiofilm, anticancer activities
Bülbül, Ali Savaş; Sen, Fatih; Bekmezci, Muhammed; Karakaya, Funda
In this study, R. aculeatus plant extract and biogenically formed AgNPs were investigated for their potential antibacterial, antibiofilm and anticancer abilities. AgNPs were characterised using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and UV-vis spectroscopy (UV-VIS). According to the Debye Scherrer formula, the particle size was found to be 32.56 nm. Disc diffusion and microdilution methods were used to investigate the antibacterial activity. In the disc diffusion study, the best results were obtained from the extract and AgNP. In the tests using plant extracts, Staphylococcus aureus ATCC 25923 showed the lowest antibiofilm activity, while Bacillus subtilis and Enterobacter aerogenes ATCC 13048 showed the highest activity. Salmonella infantis was most affected by AgNP, while Escherichia coli CFAI ATCC 25922 was least affected. Biogenically synthesised AgNPs were also investigated in cytotoxic activity studies. It was found to have the lowest concentration value on MCF-7 and HUVEC cell lines at the determined concentrations. The extract did not have any cytotoxic effect on MCF-7 cell line. HUVEC cell line showed the lowest cytotoxic activity of 10⁻³ g/mL. The antibacterial, antibiofilm and anticancer properties of R. aculeatus plant extract and biogenically produced AgNPs have been the subject of an important study. Furthermore, the comparison of the effects of plant extract and AgNPs on breast cancer cell lines and healthy cell lines provides a rich scientific material.
AtıfOpenAlex1TR Dizin1
İncele - MakaleAçık Erişim2023Fatty acid compositions and oil ratio of different species from the Brassicaceae
Onemli, Fadul; Gıdık, Betül
Crude lipid has become one of the most significant demands of nations in recent years, oil crops and their lipid yield are becoming more and more vital. The composition of fatty acids reveals the caliber of oil crops. This study aims to determine and compare the oil content and fatty acid compositions of S. arvensis, B. nigra, B. napus, S. alba and C. sativa plants. It was determined that the oil ratios of the samples belonging to the B.nigra species varied between 27.132% and 29.350%, and the oil ratios of the samples belonging to the S. arvensis species varied between 27.495% and 28.855%. It was determined that the oil ratios of the samples belonging to the B.nigra species varied between 27.132% and 29.350%, and the oil ratios of the samples belonging to the S. arvensis species varied between 27.495% and 28.855%. Erucic acid value was determined to be highest in S. arvensis species, oleic and linoleic acids in B. napus, and linolenic acid in C. sativa. The data obtained showed that the oil ratios and fatty acid compositions of S. arvensis and B. nigra were very close to the values obtained from B. napus, S. alba and C. sativa, which were used as standards and grown as cultivated plants in this study. This suggests that the wild plants S. arvensis and B. nigra have the potential to be cultivated.
AtıfOpenAlex1İncele - MakaleAçık Erişim2023Determination of the cytotoxic effect of Prangos ferulacea (L.) Lindl. which grows naturally in the foothills of Bayburt Kop Mountain, on non-small lung cancer
Kizil, Hamit Emre
The genus Prangos has been used for centuries as an antibacterial and antidiabetic agent. In this study, Prangos ferulacea (L.) Lindl. species, which is frequently encountered in various regions of our country, especially in Northeast Anatolia, and known as "çaşır or çakşır" among the people, were collected from the flora of Bayburt Kop Mountain, and methanol extract of the stem parts of this plant was obtained. Afterward, the cytotoxic effect of this extract on the non-small cell lung cancer cell line (H-460) was determined and compared with the cytotoxic activity on the lung fibroblast cell line (MRC-5). The results obtained using the Wst-8 method, it was determined that no toxic effect occurred in the MRC-5 cell line after both 24 and 48 hours of methanol extract treatment, while a toxic effect occurred in the H-460 cell line (125 μg/ml and 62.5 μg/ml) after 48 hours of application. However, this toxic effect was not statistically significant.
AtıfOpenAlex1İncele - MakaleAçık Erişim2023Could eumelanin molecule from Streptomyces parvus BSB49 strain be a potential anticancer agent for lung cancer?
Karakas, Ümıt; Bayram, Sinan; Kizil, Hamit Emre; Öztürk, Serdar
Melanins, which are divided into five different subgroups as eumelanin, pheomelanin, allomelanin, neuromelanin and pyomelanin, are a heterogeneous and amor- phous biopolymer family. Although melanin is produced in many different ways today, it is more practical, and more economical to produce melanin using bacterial strains. The eumelanin pigment, which is the subject of this study, was obtained using Streptomyces parvus BSB49 strain, and its antiproliferative effect at various concentrations against small cell (DMS-114) and non-small cell (H-460) lung cancer was determined. According to our results, the synthesized eumelanin molecule was statistically cytotoxic on non-small cell lung cancer cell line (H-460) at concentrations of 3.125 and 1.56 μg/mL after 24 hours of treatment (IC50=8 μg/mL) and only at a concentration of 3.125 μg/mL after 48 hours of treatment (IC50=8.4 μg/mL). In the small cell lung cancer cell line (DMS-114), no statistically cytotoxic concentration was detected (p<0.05).
- MakaleAçık Erişim2023Self-efficacy levels of individuals with type 2 Diabetes Mellitus in the use of diabetes drugs: The example of Gümüşhane and Bayburt province
Demirağ, Hatice; Cin, Aynur; Daştan, Buket
This study was conducted to determine the self-efficacy levels of individuals with Type 2 Diabetes Mellitus in the use of diabetes medication. The population of the descriptive study consisted of individuals with Type 2 Diabetes Mellitus residing in Gümüşhane and Bayburt provinces. The sample size was determined with the G*Power 3.1.6.9 program. A total of 315 individuals were reached in the study using a snowball sampling method. Data were collected by “Google Form” us- ing “Personal Information Form” and “Diabetes Medication Self-Efficacy Scale”. In the analysis of the data, independent groups t-test, one-way ANOVA test and Pearson product moments correlation test were used. The average age of the individuals with Type 2 Diabetes Mellitus participating in the study was 52.29±14.74 years, the duration of diabetes disease was 9.23±6.25 years, and 81% of them were men. The total average score of the participants from the “Diabetes Medication Self-Efficacy Scale" was determined as 38.70±12.36 points. It was found that the average total score of the” Diabetes Medication Self-Efficacy Scale" was higher for women than men, singles than married. Again, the total scale score averages were statistically different according to the occupational group (p<0.001). In addition, the average total score of the “Diabetes Drug Use Self-Efficacy Scale” was found to be higher for individuals who received training on diabetes drug use compared to individuals who did not receive it. It was found that the average scores of the participants from the "Diabetes Medication Self-Efficacy Scale" and its sub-dimensions were moderate. In order to increase the diabetes drug use self-efficacy levels of participants diagnosed with Type 2 diabetes, training on the use of diabetes drugs can be expanded.
AtıfOpenAlex1İncele - MakaleAçık Erişim2023Education in Disaster Situations: The Impact of The Kahramanmaraş Earthquake on Teachers' Experiences
Kuzey, Memet; Cengiz, Ekrem; Bozkaya, Hasan; Arici, Faruk
This study examines how the earthquake that occurred on February 6, 2023, in Kahramanmaraş, Turkey, has affected educational activities in the region. The research utilized questionnaires to survey teachers and gather information about the main problems they experienced after the earthquake and their solution suggestions. The findings provide valuable insights for educators and policymakers to tackle the challenges teachers and students face after a natural disaster. The study employed a basic qualitative research design within qualitative research methods. The study group comprised 42 volunteer teachers from eleven different Turkish provinces at various education levels who experienced the February 6, 2023, earthquake centered in Kahramanmaraş and participated in educational activities in the same area following the earthquake. The group of research participants was selected through easily accessible case sampling, one of the types of purposeful sampling. The data collected underwent content analysis. As per the study results, teachers detected issues that have arisen after the earthquake in the realms of educational infrastructure, psychosocial well-being, security, communication, and other factors. They then devised individual and collaborative solutions to address these challenges. Additionally, the study discussed the proposed solutions of teachers for addressing the psychosocial issues that students face in the aftermath of an earthquake. It provides crucial insights for comprehending the problems in post-earthquake education and extending support to students. Teachers' recommendations for enhancing earthquake education and awareness can significantly aid future preparedness and crisis management.
AtıfTR Dizin9İncele - MakaleYalnız künye2023As a national school of public administration todaie's graduate education academics and students' perspective
Efe, Ahmet; Yazıcı, Sinan
Public administrations are significant in providing essential public services such as justice, security, defense, and health that the market cannot fully meet and in observing the public interest. This study carried out within the scope of the theories of Tacit Knowledge and Institutional Knowledge, aimed to reveal the perceptions of the academicians working in the institution and the public personnel studying in this institution regarding the graduate education of Public Administration Institute for Türkiye and the Middle East, a national public administration school. The data obtained from the study with the phenomenology design of the qualitative research method and the academicians and public personnel with different academic formations working in other fields of the Türkiye public bureaucracy were analyzed by content analysis. As a result of the study, it is revealed that Public Administration Institute for Türkiye and the Middle East has a public administration laboratory function in disclosing the tacit knowledge in public institutions and producing high-level knowledge through the interaction of students from different disciplines and other countries. It has been understood that the systematic and multidisciplinary training of public personnel, especially senior managers, with the perspective of public interest and public service, contributes to their internalization of a strategic and general view in their institutions and thus to making the right decisions with the competence to see the big picture.
- MakaleAçık Erişim2023A Nested Square Shaped Metasurface-Based Broadband Linear Polarization Converter for Ku-Band Applications
Kaya, Yunus
This paper presents a wideband, thin, low-cost, and easy to fabricate linear polarization (LP) converter design utilizing metasurface (MS) for Ku-band (12-18 GHz) applications (also in the 18-19 GHz part of the K-band (18-27 GHz)). The design has a topology on a 1.6 mm thick FR-4 dielectric material with copper MS on the front and an entirely copper slab on the back. The presented design shows a polarization conversion ratio (PCR) of beyond 90% within the 12-19 GHz frequency band and also over 99% in the 12.5-13.1 and 16.32-17.64 GHz frequency ranges. To further give insight into the physical structure of the suggested MS-based polarization converter (PC), both the u – v axes are analyzed, and the existing surface behaviors at resonance frequencies are investigated. We compare the performance outputs with other Ku-band PCs, and the efficiencies of the suggested strategy over current MS-based LP converters are emphasized
AtıfOpenAlex1TR Dizin1İncele - MakaleAçık Erişim2023Türkiye'de Dış Ticaretin İstihdam Üzerinde Etkisinin Mekânsal Panel Veri Analizi İle Belirlenmesi
Elmalı, Kübra
Ekonomik büyüme ile doğru orantılı olan dış ticaret ve istihdam ilişkisinin incelendiği bu çalışmada, amaç istihdam üzerinde ithalat ve ihracat etkisini komşuluk ilişkilerinin dâhil edilerek araştırılmasıdır. Çalışmada, Türkiye 81 iline ait 4a, 4b ve 4c sigortalı sayısı istihdam değişkeni olarak ele alınırken yıllık ithalat, ihracat ve nüfus değerleri bağımsız değişken olarak kullanılmış ve 2009-2020 dönemi incelenmiştir. Komşuluk ilişkilerinin de etkisini dâhil eden mekânsal ekonometri uygulaması kullanılarak mekânsal Durbin, mekânsal gecikmeli ve mekânsal hata modeli olmak üzere üç başlık altında analizler yapılmıştır. Modeller Maksimum Olabilirlik (ML) yöntemi kullanılarak tahmin edilmiştir. Çalışmada iller arasındaki istihdam oranlarındaki yakınsamayı incelemek için Moran’s I endeksi hesaplanmıştır. Mekânsal model sonuçlarına göre ihracatın istihdam ile ters yönde anlamlı bir ilişkisinin olduğu belirlenirken nüfus değişkeninin istihdam ile aynı yönde anlamlı bir ilişkiye sahip olduğu görülmüştür. İthalat değişkeninin istihdam üzerinde anlamlı bir etkisi tespit edilememiştir. Komşu illerin değişkenleri incelendiğinde ithalat ve istihdam değişkenlerinin anlamlı olduğu sonucuna ulaşılmıştır.
AtıfOpenAlex1TR Dizin1İncele - MakaleAçık Erişim2023Farklı Yabani Brassica Tohumlarının Yağ Asidi Kompozisyonu ve Biyodizel Kalitesi
Girgel, Umit; Onemli, Fadul; Gıdık, Betül; Gül, Volkan
Her geçen gün artan dünya nüfusu ve gelişen sanayi alanları enerjiye duyulan ihtiyacı da artırmaktadır. Bu durum alternatif ve yenilenebilir enerji kaynaklarını ve bu kaynakların verimli kullanımı konusunu daha değerli kılmaktadır. Bu çalışmada, yabani türlerin biyodizel üretiminde kullanılabilirlik potansiyelini belirlemek amacı ile Türkiye’nin Bayburt ili ekolojik koşullarında yetiştirilen Brassicaceae familyasından Sinapis arvensis, Brassica nigra ve Brassica napus tohumlarının biyodizel kalite özellikleri ve GC-MS kullanılarak yağ asitleri kompozisyonu bölge için ilk kez belirlenmiştir. Brassicaceae familyasından çalışmada yer alan türlerin yağ verimi %30,29-46,02 arasında bulunmuştur. Ayrıca linolenik asit (%7,62-13,70) değerleri en düşük B.napus, en yüksek B.nigra’da belirlenmiştir. Parlama noktası bakımından (194-195℃) B.napus ve S.arvensis birbirine en yakın türler olduğu görülmüştür. S.arvensis ve B.nigra’nın yağ asidi kompozisyonu ve biyodizel kalite analiz sonuçları B.napus’a benzer değerlerde bulunmuştur. Yabani türler olan S.arvensis ve B.nigra’nın biyodizel kalite özellikleri ve yağ asitleri kompozisyonu bakımından yenilenebilir enerji üretim potansiyeline sahip olduğu görülmüştür.
AtıfOpenAlex3TR Dizin1İncele - MakaleAçık Erişim2023The impact of the COVID-19 pandemic on eating and food shopping habits
Demirer, Büşra; Akpolat, Hacer; Bayraktar, Mukaddes Kılıç
Objective: This study aimed to investigate the effect of the COVID-19 pandemic on eating and food shopping habits among the Turkish adult population. Material and method: Demographics, eating and food shopping habits, and food label reading habits of the participants were collected via online surveys. Coronavirus anxiety was assessed using the Coronavirus Anxiety Scale. The survey was conducted from November 2021 to the end of January 2022. Student's t-test was used to determine the statistical difference between quantitative variables. Chi-Square and Marginal Homogeneity Tests, depending on the number of categories, were used to determine the difference between qualitative variables. Results and discussion: Unpackaged food consumption decreased during the pandemic. More than half of the participants started to pay more attention to food labels, spend less time for grocery shopping, and started using nutritional supplements. The changes in eating, grocery shopping, and food label reading habits among Turkish consumers during the pandemic have been demonstrated.
AtıfOpenAlex3İncele - MakaleAçık Erişim2023Antibacterial, antifungal, antibiofilm, antioxidant, and anticancer properties of methanol extracts of some acantholimon boiss (plumbaginaceae) species
Bülbül, Ali Savaş; Sen, Fatih; Bostancı, Maşide Temiz; Uygun, Cihangir; Bekmezci, Muhammed; Bayat, Ramazan
Therapeutic properties of plants have been used since the existence of mankind. To benefit from this feature, the discovery of the active components of plants has gained momentum today. One of these plant species is Acantholimon Boiss. This plant extract has antifungal, antimicrobial, and anticancer properties. In this article, antimicrobial, antifungal and antioxidant capacities and antibiofilm properties of Acantholimon Boiss plant extract on 15 bacterial and 2 fungal species were evaluated. Antimicrobial properties were evaluated by Agar Well Diffusion method. It was observed that the plants formed a zone diameter of 12-18 cm. Minimum Inhibition Concentration (MIC) and Minimum Bactericidal Concentration (MBC) tests were used to determine the minimum active property. Biofilms of almost all bacteria were reduced by 10-50% by Acantholimon species at doses of 8 mg/ml-16 mg/ml. For MCF-7 cells, the IC50 values for A. acerosum subsp. brachystachyum (Boiss. ), A. acenum var. balansae, A. armenum var. balansae and A. kotschyi were 0.143 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml and 0.107 mg/ml, respectively. The same doses did not show a cytotoxic effect on HUVEC cell lines. With this article, it has given important results in terms of having a wide range of bacterial studies and examining its activities in fungi and cell lines. These findings suggest that extracts of Acantholimon Boiss species may be a potential source of natural medicines and antibacterial, antifungal, antibiofilm, antioxidant, and anticancer activities may support their therapeutic use.
- MakaleYalnız künye2023A Cross-Cultural Analysis of a Turkish EFL Textbook: Hu and McKay's Analytic Framework
Dolgunsöz, Emrah; Azimzadeh, Monireh
Due to rapid globalization, culture is an essential element of foreign language pedagogy. Cross-cultural communication and foreign language learning have become increasingly important since it provides the common basis for intercultural contact. Textbooks are crucial pedagogical resources in the EFL context since they are the primary sources of building intercultural understanding. The main purpose of this study was to explore how a local Turkish EFL textbook presented interlingual and intercultural diversity in Turkish EFL classrooms. Hu and McKay's (2014) analytic framework was adopted to investigate the linguistic and cultural contents of the textbook. The findings revealed that the textbook needed more group work activities, which does not promote communication enough. In addition, the cultural content was dominated by the native culture (Turkish). In the textbook, mainstream contexts (i.e., family, school, holidays) along with local Turkish cultural elements formed the majority of the settings. In addition, places, names, and events were mainly from Turkiye, while these elements from other cultures, including Anglo-American, were limited. Finally, cross-cultural conversations were included; however, the topics chosen were about Turkiye and popular culture. These findings were discussed regarding cross-cultural communication, EIL and practical ELT pedagogy.
AtıfOpenAlex1TR Dizin1İncele - MakaleAçık Erişim2023Combination of Conventional Ball Mill and Stirred Mill to Obtain Ultra-Fine Talc
Uçurum, Metin; Güleç, Ömer; Toraman, Oner Yusuf
In this study, it was investigated that talc ore could ground to very fine sizes using a combination of conventional ball mill and vertical stirred mill. Firstly, the conventional ball mill parameters such as mill speed (% of critical speed), material filling ratio (Jb), ball filling ratio (fc), ball size distribution (10-20-30-40 mm, %), grinding aid ratio (% of powder) and grinding time (min.) were optimized using classic experimental design. As a result of the optimization, fine talc product was obtained with d90=93.52 µm particle size. In the second stage, the ball mill product was re-milled using a stirred mill. As a result of study, a final ultra-fine talc powder was obtained after 60 minutes grinding time with d50=1.85 µm particle size and 14058 cm2/g total surface area. It has been seen that the conventional ball mill+stirred mill combination effective a process to obtain talc powder that suitable for industrial use.
- MakaleAçık Erişim2023The Future of Export-Based Growth Policies in the Turkish Economy: An Econometric Simulation Approach
Coşkun, Hüseyin; Imamoglu, Ilyas Kays
The failure of the import substitution industrialization policies implemented in the Turkish economy between 1960 and 1980 led to the adopting of export-oriented policies for economic growth. In 1980, radical transformations were experienced in economic policies. Since 1980, exports have been attributed important meanings for sustainable economic growth. Therefore, this study analyzes the long-run and short-run relationship between exports and economic growth in the Turkish economy by using the ARDL bounds test approach with annual data sets for the period 1987-2021 and forecasts Turkey's GDP per capita for the period 2022-2032 by econometric simulation method. The ARDL model estimation results show that exports have a statistically significant and positive effect on economic growth in the short and long run. According to the forecast analysis, it has been determined that the per capita GDP in 2032 will be $20990 in the base export scenario, $17327 in the low-export scenario, and nearly double to $25157 in the high-export scenario. These results show that it is possible for the GDP per capita to nearly double in the next ten years in the Turkish economy. Still, policy components are needed to increase exports by an average of 13.86% annually to reach these figures.
AtıfOpenAlex3TR Dizin3İncele - MakaleAçık Erişim2023Evaluation of Noise Levels in Flour Factories in Terms of Occupational Health and Safety
Albayrak, Sirer; Melike, Yağcı; Ozdemir, Mustafa
This study aims to determine the daily noise exposure levels in flour mills and evaluate the effects on the health and safety of workers. The study measured the equivalent sound pressure levels of workers exposed in two flour mills operating in Konya province in dBA. The factories include machines with high noise levels, such as sifters, sieves, and rollers. A Type-2 class sound pressure level meter was used in the measurements taken in accordance with ISO 9612: 2009 standard. Based on the measured values, the A-weighted equivalent sound pressure levels were determined, and the daily personal noise exposure levels were calculated taking into account the working hours. It was determined that the equivalent sound pressure levels and the daily individual noise exposure levels of the workers were in the range of 88.2-97.7 dBA and 87.9-97.4 dBA, respectively, and above the minimum daily personal exposure limit (80 dBA) specified in the legislation. As a result of the study, it was evaluated that the noise in flour mills can negatively affect the health and safety of workers as well as their job performance.
AtıfOpenAlex3TR Dizin3İncele - MakaleAçık Erişim2023Ultrasonic extraction conditions using response surface methodology: total phenolic content of bee pollen
Sahin, Huseyin; Can, Zehra; Gürgen, Ayşenur; Kara, Yakup
Bee pollen plays a significant role in bee nutrition, bee population sustainability, pollination processes, and its health and nutritional benefits for humans. It contains protein, vitamins, minerals, and antioxidants, offering valuable nutritional properties. The total phenolic content (TPC) is an important parameter in determining the nutritional and health value of pollen. The presence of high levels of phenolic compounds in pollen enhances their health benefits and can provide protective effects against diseases by combating oxidative stress. In the study, ultrasonic extraction conditions for pollen were optimized using the Response Surface Method to maximize TPC. The experimental study was designed according to Box-Behnken design: 30–70% ethanol ratio, 5–15 min of extraction time, and 10–20% ultrasonic amplitude modulation (AM). The TPC of the obtained extracts were determined using the Folin-Ciocalteu procedure. The optimal extraction conditions were predicted as 60.012% ethanol ratio, 11.054 min, and 19.160% AM for reaching 9.572 mg/GAE g extract.
AtıfOpenAlex3İncele - MakaleAçık Erişim2023Prioritising and selecting the railway routes planned in the Eastern Black Sea Region with the AHP and TOPSIS methods
Boz, Ediz; Türk, Ersin; Togan, Vedat
The construction of the railway, which is needed for the development of the Eastern Black Sea Region, is an issue that has been discussed and unresolved for about 110 years. The geomorphological structure of the region and the developments in the highway played a role in the delay of the railway construction. However, the developing technology in the railway, Turkey's being a part of the Iron Silk Road Project, and the agreements made with international connections have brought the railway construction to the region again. In the Environmental Plan (EP) approved and in force by the Ministry of Environment, Urbanization and Climate Change, four railway routes are planned to integrate the Eastern Black Sea region with the national/international railway network. These routes are; Samsun-Sarp, Trabzon-Erzincan, Of -Erzurum and Tirebolu-Bayburt. However, some of these routes are alternatives to each other and are not feasible and rational since the implementation of all planned routes requires great costs. The aim of this study is to develop a method for prioritizing and selecting the railway routes planned in the EP. Within the scope of this purpose, by using Analytical Hierarchy Process (AHP) and TOPSIS techniques, which are multi-criteria decision making methods, the routes were listed according to 4 criteria and 10 sub-criteria determined with the help of literature and expert team. As a result of the study; In both techniques, the order was the same and it was determined that the Samsun-Sarp railway was the most priority railway route. Trabzon-Erzincan came second, Of-Erzurum came third and Tirebolu-Bayburt came fourth.
AtıfWoS3OpenAlex3TR Dizin2
İncele - MakaleAçık Erişim2023Investigation of the relationship between NFKB1 polymorphisms and telomere length and apoptosis in patients with type-2 diabetes
Dirican, Ebubekir; Kaya, Yasemin
Purpose: Type 2 diabetes mellitus (T2DM) is a heterogeneous, chronic, and metabolic disease that affects a significant proportion of the global population. This study aimed to evaluate the effect of NFKB1-94 ATTG ins/del polymorphisms on the expression of apoptosis genes and telomere length (TL) in patients with T2DM compared with healthy individuals.Materials and Methods: Sixty-nine T2DM patients and sixty healthy people were enrolled in the study. DNA and RNA were isolated from the blood samples. NFKB1 genotypes were identified by Sanger sequencing. For TL analyses and to investigate the expression of the caspase-3, caspase-9, bax, and bcl2 genes, RT-PCR was utilized.Results: There was a significant difference between the NFKB1-94 ins/del genotype patients and the control group (OR:0.4792 (0.2345-1.011)). However, the distribution of other genotype/alleles (ins/ins and del/del) showed no difference between T2DM and control groups. The allelic frequency of NFKB1-94 ins/del was 0.455/0.235 for the T2DM group and 0.435/0.165 for the control group. An increase in the mRNA expression of caspase-3, caspase-9 and Bax genes was observed in the T2DM group compared with the healthy group, while a decrease in the Bcl2 gene was found in the T2DM group. TL in T2DM patients was shorter than in healthy individuals.Conclusion: NFKB1-94 ins/del polymorphisms show significant differences in T2DM patients. We observed that apoptosis was activated and TL was shortened in patients with T2DM. However, no relationship between NFKB1 polymorphisms and apoptosis and TL could not be determined.