Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Dertli, Enes(117)
- Kaya, Yunus(51)
- Şahin, Engin(48)
- İspirli, Hümeyra(47)
- Özen, Soner(46)
- Şenay, Volkan(45)
- Pat, Suat(44)
- Can, Zehra(39)
- Bayraktar, Bülent(37)
- Bayram, Sinan(37)
- Korkmaz, Şadan(36)
- Cuce, Erdem(35)
- Ecem Bayram, Nesrin(33)
- Kutlu, Naciye(33)
- Yilmaz, Mustafa Tahsin(32)
- Artar, Musa(31)
- Ertugrul, Mehmet(30)
- Öner, Erdal(30)
- Ayata, Ümit(29)
- Hasar, Ugur Cem(29)
- Esmer, Yusuf(28)
- Mercan, Emin(27)
- Cuce, Pinar Mert(26)
- Özdemir, Akın(25)
- Çolak, Murat(24)
- Bayram, Ozkan(23)
- Kamiloğlu, Aybike(23)
- Sert, Durmuş(22)
- Ayazoglu, Rabil(21)
- Abdioglu, Murat(20)
- Bayram, Nesrin Ecem(20)
- Kadakal, Mahir(20)
- Kara, Yakup(20)
- Kizil, Hamit Emre(20)
- Tozlu, Alperen(20)
- Birinci, Ahmet(19)
- Gerçek, Yusuf Can(19)
- Battal, Fetullah(18)
- Dirican, Ebubekir(18)
- Ergün, Mustafa(18)
Yayınlar
- MakaleAçık Erişim2023Scopus SJRQ1New RSM-FEM-Based Active Lateral Earth Thrust Coefficient Determination Method for Inverted T-Type Cantilever Retaining Walls Supporting Narrow Granular Backfill
Kamiloglu, Hakan Alper
This study was aimed to (1) investigate the failure surface mechanism occurring behind the wall supporting narrow backfill with experimental and numerical approaches; (2) determine the effect of internal friction angle (phi), friction (delta), heel length (beta), foundation thickness (alpha), backfill inclination (psi), and backfill width (theta) parameters on lateral earth thrust coefficients; and (3) derive finite-element analysis (FEM)-response surface method (RSM)-based lateral earth thrust coefficient equations for inverted T-type retaining walls supporting narrow backfill. The study was performed for granular backfill. A small-scale test was performed to investigate the failure surface mechanism in the narrow granular backfill. The particle image velocimetry method was employed to determine failure surface patterns for various heel lengths and backfill widths. Finite-element (FE) analyses were also performed to verify the experimental results. From the analyses, it was seen that two characteristic soil blocks formed behind the horizontally translated wall. Due to these soil blocks, the wall was divided into three characteristic regions. Lateral active earth thrust coefficients were derived for the regions. RSM was employed to derive FE-based lateral earth thrust coefficient estimation equations for each region. In this context, three design matrices were created, comprising 76 runs. In the design, parameters phi, delta, beta, alpha, psi, and theta were used as independent variables. A total of 76 FE analyses were performed for various parameter combinations. The results of the FE analyses were used as a response. From the statistical analyses, lateral active earth thrust estimation equations for narrow backfill were derived. The suggested equations were compared with the results of experimental, numerical, and analytical studies, and it was seen that the method gives reliable results. The effects of independent variables and their interactions on lateral earth pressure coefficients were examined.
AtıfWoS3OpenAlex3
İncele - MakaleAçık Erişim2023STRONGLY HYPERBOLIC TYPE CONVEXITY AND SOME NEW INEQUALITIES
Kadakal, Huriye; Kadakal, Mahir
In this study, we introduce and study the concept of strongly hyperbolic type convexity functions and their some algebraic properties. We obtain Hermite-Hadamard type inequalities for the strongly hyperbolic type convex functions. After that, by using an identity, we get some inequalities for strongly hyperbolic type convex functions. In addition, we compare the results obtained with both Holder, Holder-Iscan inequalities and power-mean, improved power-mean integral inequalities.
AtıfWoS2OpenAlex2İncele - Kitap BölümüYalnız künye2023Can Bilingual Books Promote Self-Paced Foreign Language Learning: A Qualitative Study
Dolgunsöz, Emrah; Kimsesiz, F; Atac, BA
Books that include multiple languages have been published in various languages since the 1980s in the United States, mainly for the Latino population to promote language learning and literacy (Ernst-Slavit and Mulhern, 2023) and recently have started to become popular. Bilingual texts may benefit language learners since embedded translations may help increase grammatical awareness, provide L1 preview, support L1 positive transfer and even promote L1 identity. Considering some advantages of bilingual books, this qualitative study examined if bilingual texts can be a good and cheap option for self-paced language study. 6 EFL learners without Spanish knowledge were asked to study 2 bilingual books (Spanish-Turkish) for 10 weeks. Their progress was tracked through their personal reflections periodically. A semi-structured interview was employed at the end of a 10-week period to scrutinize their recommendations and opinions. The results showed some pros of these texts, such as cost, ease of use and direct translation of sentences. These materials, however, were not without cons. The participants emphasized a lack of quality and visuals, inefficiency when not complemented with a language course, complexity of grammar and verb inflections despite translations and lack of motivation due to daily routines. The participants also reported that adopting an intense study strategy, such as writing and taking notes on grammar and vocabulary, may be very time-consuming and tedious. In conclusion, bilingual books for self-paced study were found to have a number of challenging issues and it was best to use them as supplementary material to any language course.
- MakaleYalnız künye2023MULTIPLICATIVELY PREINVEX P-FUNCTIONS
Kadakal, Huriye; Kadakal, Mahir
In this study, using both Holder's integral inequality and Holder-Iccan integral inequality, some inequalities of Hermite Hadamard type obtained for multiplicatively preinvex P -functions are given. Afterwards, the result obtained with Holder-Iccan inequality has been shown to be better than that obtained with Holder's integral inequality.
AtıfWoS19İncele - MakaleAçık Erişim2023Development of self-regulation scale for middle school students: Validity and reliability study
Sarikaya, Ismail; Ozturk, Mesut; Ozgol, Mustafa
This study was conducted to develop a valid and reliable measurement tool that can identify middle school students' self-regulation skills. Firstly, the literature was utilized in the development of the measurement tool. The form was finalized with the support of the opinions of different experts and a trial application. Then, the form was administered to 341 middle school students to determine its construct validity, and exploratory factor analysis (EFA) was performed on the collected data. Then, the form was administered to 341 middle school students to determine its construct validity, and exploratory factor analysis (EFA) was performed on the collected data. As a result of the study, it was determined that the scale consisted of 9 items and two sub-dimensions, namely forethought and volitional control and self-reflection. In order to reveal the reliability of the scale, internal consistency, two-half test analyses, and composite reliability (CR) were used, and it was determined that the values found were .74 and above. In order to reveal the accuracy of the obtained structure, data were collected from 218 middle school students in a different province, and confirmatory factor analysis (CFA) was performed with these data. As a result of the analysis, the two-factor structure of the scale was confirmed. When the findings are examined, it can be said that the scale is a reliable and valid tool that can be applied to determine the self-regulation skills of students studying at the middle school level.
AtıfWoS1OpenAlex4TR Dizin2
İncele - MakaleAçık Erişim2023LRIG1 levels in chronic rhinosinusitis with nasal polyps
Uzunçakmak, Sevgi Karabulut; Sahin, Abdulkadir; Özçelik, Aysegul Tavaci; Halici, Zekai
Purpose: Nasal polyps (NPs), usually occurring together with chronic rhinosinusitis (CRS), are benign masses of mucosal origin arising from inflammation. The transmembrane protein known as leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) is a member of the Lrig family. Lrig1 is frequently expressed in the respiratory tract and epithelial tissues and can inhibit several signaling pathways involved in cell proliferation. The aim of this study was to determine Lrig1 levels in NP tissues of patients with CRS. Material and Methods: This study included 36 patients with CRS and NPs and 15 patients who underwent rhinoplasty as the control group. The Lrig1 levels of all participants were measured by the ELISA method.Results: This study revealed that Lrig1 levels were significantly lower in NP tissues than in tissues of the control group. The mean level of Lrig1 of the NP tissues was 22.2 ng/ml, while the mean level of the control group was 28.5 ng/ml. According to the results of ROC analysis, Lrig1 levels have the power to distinguish polyp tissues from control tissues (AUC=0.794). Lrig1 levels were higher in tissues with scores of 4-8 than in tissues with scores of 16-20 based on the results of computed tomography scoring. According to endoscopic evaluations, Lrig1 levels of tissues with scores of 5-8 or 9-11 were relatively lower than those of tissues with scores of 2-4.Conclusion: Lrig1 levels were found to be decreased in NP tissues. Thus, Lrig1 may be used to confirm the presence of NPs. Lrig1 may also be helpful in NP grading. Increasing the Lrig1 levels in cases of NPs has the potential to become a targetable treatment modality.
AtıfWoS1OpenAlex1TR Dizin1İncele - Derleme MakaleAçık Erişim2023THE EVOLUTION OF CUSTOMER CITIZIENSHIP BEHAVIOR RESEARCH: SYSTEMATIC REVIEW AND BIBLIOMETRIC ANALYSIS
Sunaoglu, Serife Kazanci; Özdemir, Neslisah
Customer citizenship behavior has been a remarkable concept in recent years, particularly in service research, due to the numerous benefits it provides from both the customer and the company's perspectives. This study aims to give a comprehensive view utilizing bibliometric methodologies and to provide a systematic evaluation of the growing literature on customer citizenship behavior. In this vein, a systematic review was conducted by applying content and bibliometric analysis to 151 emprical research articles in the Scopus database. The findings are discussed under the headings of descriptive overview and bibliometric mapping (year, author, country, journal, citation, keyword), theoretical background, studies used in measurement, methodological approaches (research design, data collection method, population, sample size, sampling method, analysis, industry) and related variables (antecedents, consequences, mediators and moderators). This study contributes to the body of knowledge by clarifying the literature on customer citizenship behavior, presenting the current situation, identifying gaps, and making recommendations for future research.
- MakaleAçık Erişim202321st Century Skills in Curriculums of Turkey, Alberta, Korea and Singapore
Ozen, Nesime Ertan; Kaplan, Kadir
It is aimed to compare the content of mother tongue curriculums at secondary school level in Alberta, Korea and Singapore. In the study, which was designed in accordance with the holistic multiple case study, one of the qualitative research designs, the data collected on the P21 classification were analyzed by descriptive content analysis. When we look at curriculum in general, it has been determined that the learning outcomes of 21st century skills in all of the programs are close to equal distribution in grades. Among the 21st century skills, learning and innovation skills were found to be the skill most associated with learning outcomes for Korea Secondary School Mother Tongue Curriculum, Singapore Secondary School Mother Tongue Curriculum and Turkish Language Curriculum. It is understood that the skills based on learning to learn, problem solving, associating knowledge with previous learning, critical and creative thinking comes to the fore in the learning outcomes, and it is aimed to educate individuals in this direction. It is understood that the learning outcomes related to flexibility and adaptation skills under life and career skills are not included in all programs. In addition, the lack of learning outcomes in initiative and self-direction, productivity and accountability skills in Alberta Secondary School Mother Tongue Curriculum and Singapore Secondary School Mother Tongue Curriculum shows that life and career skills, which are among the 21st century skills, are neglected in these programs.
AtıfOpenAlex1TR Dizin1İncele - MakaleAçık Erişim2023How Does Cynicism Mediate Spiritual Leadership and Organizational Commitment? The Case of Turkish and Indonesian Universities
Battal, Fetullah; Ibrahim, Azharsyah
This study seeks to determine the role of cynicism in the relationship between the perceived spiritual leadership of university employees and their organizational commitment. Because of the international nature of the problem at hand-university staff in Turkey and Indonesia who are engaged in ongoing educational activities-a comparison strategy predicated on cultural differences was favored. The study utilized correlation analysis and normal distribution determination in SPSS, and structural equation modeling in AMOS to reveal regression relations. Findings suggest that academics in Turkey and Indonesia are more committed to their institutions when they have a positive perception of the organization's spiritual leadership. Likewise, when university employees perceive cynicism in the organization, their commitment to spiritual leadership and the organization reduces. In other words, cynicism appears to partially mediate the relationship between spiritual leadership perception and organizational commitment in both countries.
AtıfWoS1OpenAlex10TR Dizin1İncele - MakaleYalnız künye2023Criticism of Wāhhabism in Jamil Sidqi al-Zahāwi's al-Fajr al-Sādiq
Inal, Ibrahim Hakki; Sever, Mehmet
Wahhabism, which emerged in the mid-18th century, is a movement that draws attention with its reactivity in Islamic thought. The views of its founder, Muhammad b. 'Abd al-Wahhab, were built to deny the centuries-old religious understanding of the Muslim community, based on a bida'-centered thought. In this direction, Wahhabism has transformed the elimination of institutions and structures that it regards as signs of disbelief into a structural character. This study examines the critical treatise on Wahhabism by the Iraqi poet Jamil Sidqi al-Zahawi (d. 1936), who was disturbed by its activities in Iraq. Zahawi wrote al-Fajr al-Sadiq to reveal the historical origins of Wahhabism and criticise its political and religious activities, and tried to explain the unknown aspects of this religious movement. The work, in terms of its content, has examined the issues that occupy the agenda of Muslim society such as shirk (polytheism), bida' (heretical innovation), tawassul (request), and takfir (excommunication). The work, which is a refutation, draws attention as an important source in scholarly studies on Wahha-bism in terms of its content. In this study, the theoretical and historical criticism put forward by Zahawi will be tried to be revealed by using the textual analysis method. According to Zahawi, Wahhabism is a movement instrumentalised for political rather than religious pur-poses. The sociological basis of this structure, which is based on Kharijite thought, is based on tribalism and contains reactionism against the other.
- MakaleAçık Erişim2023Scopus SJRQ3Yield, yield components and fatty acid composition of Artemisia dracunculus L. local breeds under organic cultivation conditions
Göktas, Ozlem; Gidik, Betul
The importance of medicinal and aromatic plants in people's lives is growing due to their various uses and diverse cultivation conditions. This study aimed to determine the yield and yield components and quality features (oil ratio and fatty acid composition according to GC-MS) of six different tarragon (Artemisia dracunculus L.) local breeds grown organically in Bayburt province, Turkey. For this purpose, the data obtained by growing the plants in the experimental area during the two crop years, 2018 and 2019, were evaluated. As for the yield values, the highest values for green herb yield (275.41 kg ha-1), drug herb yield (99.89 kg ha-1), drug-herb percentage (44.00%), green leaf yield (208.97 kg ha-1), green leaf percentage (75.09%) and drog leaf yield (72.48 kg ha-1) were found in the local breed from Bayburt Central location. It was found that the oil percentages, evaluated to determine the quality traits, ranged from 5.39% to 7.02%. The most important fatty acid was alpha-linolenic acid (9.49%-23.1%), followed by linoleic acid (4.18%-13.89%) and palmitic acid (4.05-13.89%). As far as we know, this is the first study investigating tarragon's total oil content and fatty acid composition. The results show that the total oil content of this plant, which has remarkable pharmacological effects, is present in useful quantities compared to the leafy green and does not contain fatty acids that prevent its consumption as food. Therefore, this plant is expected to be used directly in various food products.
AtıfOpenAlex1İncele - MakaleAçık Erişim2023STRATEGIC MARKETING MANAGEMENT IN SMES: THE CASE OF L?LEBURGAZ
Saylan, Onur; Esmer, Yusuf; Çelik, Pelin
Due to the changing conditions and new developments in the business world in recent years, SMEs in Turkey need to adopt a strategic marketing management approach in order to be successful and gain competitive advantage. Strategic marketing management, on the other hand, is the process of managers developing marketing strategies by identifying the strengths and weaknesses, threats and opportunities of the business towards marketing and applying these strategies. In this study, it is aimed to develop strategies for the marketing activities of these enterprises and to contribute to the relevant literature by making strategic analyzes of SMEs in the context of marketing, based on the example of Luleburgaz. For this purpose, first of all, the strengths and weaknesses, threats and opportunities of 17 SMEs operating in Luleburgaz district were determined by using the SWOT analysis technique. Then, based on the data obtained, 4 basic marketing strategies were developed by applying the expert opinion and using the SWARA method. These; (1) using quality materials and producing quality products to sell quality products, (2) developing a digital customer relationship management system, (3) engaging in digital and social media marketing activities, (4) reducing raw material costs.
AtıfOpenAlex2TR Dizin2İncele - MakaleAçık Erişim2023Scopus SJRQ1The Phenolic Profile and Anti-Inflammatory Effect of Ethanolic Extract of Polish Propolis on Activated Human Gingival Fibroblasts-1 Cell Line
Kurek-Górecka, Anna; Klósek, Malgorzata; Pietsz, Grazyna; Czuba, Zenon P.; Kolayli, Sevgi; Can, Zehra; Balwierz, Radoslaw; Olczyk, Pawel
Propolis, owing to its antibacterial and anti-inflammatory properties, acts as a cariostatic agent, capable of preventing the accumulation of dental plaque and inhibiting inflammation. The anti-inflammatory properties of propolis are attributed to caffeic acid phenethyl ester (CAPE), which is present in European propolis. The objective of the conducted study was to assess the anti-inflammatory effects of the Polish ethanolic extract of propolis (EEP) and isolated CAPE on stimulated with LPS and IFN-alpha, as well as the combination of LPS and IFN-alpha. The cytotoxicity of the tested compounds was determined using the MTT assay. The concentrations of specific cytokines released by the HGF-1 cell line following treatment with EEP (25-50 mu g/mL) or CAPE (25-50 mu g/mL) were assessed in the culture supernatant. In the tested concentrations, both CAPE and EEP did not exert cytotoxic effects. Our results demonstrate that CAPE reduces TNF-alpha and IL-6 in contrast to EEP. Propolis seems effective in stimulating HGF-1 to release IL-6 and IL-8. A statistically significant difference was observed for IL-8 in HGF-1 stimulated by LPS+IFN-alpha and treated EEP at a concentration of 50 mu g/mL (p = 0.021201). Moreover, we observed that CAPE demonstrates a stronger interaction with IL-8 compared to EEP, especially when CAPE was administered at a concentration of 50 mu g/mL after LPS + IFN-alpha stimulation (p = 0.0005). Analysis of the phenolic profile performed by high-performance liquid chromatography allowed identification and quantification in the EEP sample of six phenolic acids, five flavonoids, and one aromatic ester-CAPE. Propolis and its compound-CAPE-exhibit immunomodulatory properties that influence the inflammatory process. Further studies may contribute to explaining the immunomodulatory action of EEP and CAPE and bring comprehensive conclusions.
AtıfWoS17OpenAlex19
İncele - MakaleAçık Erişim2023Effect of Reboxetine Treatment on BDNF, Synaptophysin, and PSD-95 Levels in the Spinal Dorsal Horn of Rats with Diabetic Neuropathy
Yücel, Nazli Turan; Üçel, Umut Irfan; Özkay, Umide Demir; Ulupinar, Emel; Can, Ozgur Devrim
Objective: It is known that neuropathic pain is accompanied by alterations in the levels of neurotrophic factors and synaptic proteins in the microenvironment of the spinal dorsal horn. Such changes contribute to hyperalgesia and allodynia processes; thus, analgesic drugs can exert their pharmacological effects by affecting the expressions, levels, or functions of these endogenous substances. In this study, based on the knowledge that reboxetine (a selective noradrenaline reuptake inhibitor) has the potential for antihyperalgesic efficacy in diabetic neuropathy, we aimed to examine the probable effects of this drug on diabetes-induced changes in brain-derived neurotrophic factor (BDNF), synaptophysin (the pre-synaptic marker of synaptic integration), and postsynaptic density-95 (PSD-95) (the postsynaptic marker of synaptic integration) levels in the superficial laminae of the dorsal horn.Methods: Experimental diabetes was induced by a single-dose injection of streptozotocin (STZ) (50 mg/kg) in rats. After four week-long induction period of painful diabetic neuropathy, rats were treated orally with 8 mg/kg reboxetine for two weeks. Hyperalgesia responses were evaluated by using the Randall-Selitto and Hargreave's tests. Following the pain tests, immunohistochemical studies were performed.Results: Two weeks of reboxetine administration increased the reduced paw withdrawal thresholds and shortened the paw withdrawal latencies of diabetic rats in neuropathic pain tests, indicating the antihyperalgesic efficacy of this drug. Moreover, augmented BDNF and synaptophysin levels in diabetic rats reversed by reboxetine treatment. However, there was no alteration in the densities of PSD-95, in both STZ-diabetic and reboxetine-treated STZ-diabetic rats.Conclusion: The obtained results suggested that inhibition of central sensitization and modulation of spinal plasticity seem to be pharmacological mechanisms underlying reboxetine's antihyperalgesic effects on diabetic rats. However, further studies are still needed to clarify the exact mechanism of action.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2023The success of critical velocity protocol on predicting 10000 meters running performance
Çabuk, Baris; Demirarar, Onur; Cin, Merve; Çabuk, Refik; Özçaldiran, Bahtiyar
Background and Study Aim The study aims to evaluate which of the critical velocity (CV) estimates of the three widely used models and the best-fit model successfully predict the running performance of 10000 meters. Material and Methods The group of participants in this study consisted of 11 British endurance athletes. The CV estimations were obtained from the models with the athletes' running velocity and exhaustion times of 1500, 3000, and 5000 meters (m). The information was taken from a website where the results of the British athletes are recorded. In terms of selecting endurance athletes, the data of the athletes who ran 1500 m, 3000 m, 5000 m, and 10000 m in the same two years were included in this study. By fitting the data into mathematical models, the CV estimates of the three mathematical models and the individual best-fit model were compared with the 10000 m running velocity. The CV estimates were obtained by fitting the relevant data on the running velocity, exhaustion time, and running distance of the three running distances of athletes to each of the three mathematical models. Results 10000 m running velocity and times of the athletes corresponded to 19.65 +/- 1.26 km/h and 30.4 +/- 1.94 minutes, respectively. The CV values obtained from the three mathematical models and 10000 m running velocity were similar (p > 0.05). Although the lowest total standard error levels were obtained with the best individual fit method, the 10000 m running velocity was overestimated (p < 0.05). Conclusions Three mathematical models predicted 10000 meters of race velocity when an exhaustion interval between 2-15 minutes was used. Even though the mathematically most valid CV value was obtained with the best individual fit method, it overestimated the 10000 m running velocity. When comparing the values of CV and the velocity of running 10,000 meters, our study suggests using the model. This is because the model has the smallest effect size, and there is no statistically significant difference in the total standard error level between the model and the best-fit model.
AtıfWoS1İncele - MakaleAçık Erişim2023Beneficial Effect of Atomoxetine Treatment on Scopolamine-Induced Cognitive Impairments and Molecular Changes in Rats
Yucel, Nazli Turan; Ucel, Umut Irfan; Kandemir, Ummuhan; Can, Ozgur Devrim
Objective: Atomoxetine is a noradrenaline re-uptake inhibitory drug that is currently used in the pharmacological treatment of attention deficit/hyperactivity disorder in children, adolescents, and adults. Based on the findings that noradrenergic system is closely associated with learning and memory processes, dysfunction of this system might contribute to the pathophysiology of cognitive disorders. Therefore, atomoxetine, which alters the noradrenergic neurotransmission in the synaptic cleft, has a potential to modulate learning and memory functions in various areas of the central nervous system. In the present study, it was aimed to investigate the effects of atomoxetine treatment on the cognitive impairments in amnesic animals using behavioral and immunohistochemical methods.Methods: Male Sprague-Dawley rats (adult, weighing 250-300 g) were used in the experiments. Atomoxetine at doses of 3 or 6 mg/kg (i.p.) was administered to the rats for 14 days. Experimental amnesia was induced in the animals by applying scopolamine (0.5 mg/kg, i.p.) injection. Following the treatment protocol, Morris water maze and passive avoidance tests were conducted to assess spatial and emotional learning and memory parameters of rats, respectively. Piracetam (300 mg/kg daily for 14 days) was used as reference drug in these experiments. In addition, motor performances of the animals were evaluated by activity cage and Rota-rod tests. Subsequent to behavioral tests, rats were euthanized and immunohistochemical analyses were performed to determine the alterations in the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels in the hippocampi of the animals.Results: In the Morris water maze test, amnesic rats found the hidden platform slower and spent less time in the target quadrant compared to the healthy controls. On the other hand, atomoxetine treatments significantly decreased the escape latencies, and also increased the target quadrant time values of the amnesic animals at both doses. Data obtained from the passive avoidance test showed that second transition latency values of the amnesic rats were significantly shortened with respect to the control animals; while atomoxetine treatment prolonged these shortened values significantly. It was observed that atomoxetine did not alter motor coordination or spontaneous locomotor activities of animals. Moreover, this drug increased the BDNF and NGF levels in the hippocampal sub-regions which were diminished by scopolamine administration.Conclusion: The obtained findings showed that atomoxetine treatment significantly improved the impaired learning and memory performances of the rats induced by scopolamine administration. Furthermore, anti-amnesic effects of this drug were concomitant with increased neurotrophic factors levels in the hippocampal brain regions. These results suggest a notable therapeutic potential of this drug in the treatment of dementia and several cognitive disorders; however, it should be underlined they are needed to be confirmed by welldesigned clinical trials.
AtıfWoS3OpenAlex3İncele - MakaleAçık Erişim2023Analysis of telomere length in patients with COVID-19 and investigation into its relationship with clinical- demographic data
Savrun, Atakan; Dirican, Ebubekir
Purpose: Novel coronavirus disease 2019 (COVID-19) is an infectious disease unknown before the 2019 outbreak in Wuhan. This study evaluated telomere length in COVID-19 (+) and (-) samples with clinical-demographic parameters.Materials and Methods: DNA was isolated from COVID-19 (+) (n=70) and (-) (n=70) patients. Telomere length was determined by real-time-PCR (RT-PCR). The 2- increment increment Ct method was used to analyze the telomere length of the samples.Results: There were significant differences in creatinine, LDH, ferritin, WBC, NEU and CRP in COVID-19 (+) patients compared to COVID-19 (-) patients. The NEU/LYM (or N/L) ratio was found higher in the patients with COVID-19 (+), than in COVID-19 (-). On the other hand, our COVID-19 (+) patients (mean +/- std:0.93 +/- 0.58) had significantly shorter telomere lengths than the COVID-19 (-) (mean +/- std:1.26 +/- 0.76). Moreover, COVID-19 (+) male patients (mean +/- std:1.06 +/- 0.50) had longer telomere length than female patients (mean +/- std:0.76 +/- 0.54). Telomere length was significantly shorter in patients with COVID-19 (+) with high blood urea nitrogen (BUN), high creatinine, high hematocrit, high NEU levels, normal platelets (PLT), and low WBC levels.Conclusion: Our findings suggest that telomere length and blood parameter levels influence the severity of COVID-19. Blood parameters differed in patients with COVID-19 (+) and COVID-19 (-). As a result, increasing the number of similar studies in the future can demonstrate the significance of our findings.
AtıfWoS2OpenAlex2İncele - MakaleYalnız künye2023Scopus SJRQ2THE EFFECTS OF STRATEGY TRAINING ON THE USE OF IMPLICATIONS FROM THINK-ALOUD AND EYE-TRACKING DATA
Utku Bilici, Ozlem; Subasi, Gonca; Dolgunsoz, Emrah
Considering the critical role of readings strategies in L2 reading this study aimed to investigate the impact of strategy training on Turkish EFL learners' use of global reading strategies. 23 freshmen, enrolled in the ELT Department, participated in the study, and the data were collected through eye tracking and thinkaloud protocols. The results are encouraging for the use of reciprocal teaching, one of the comprehensionenhancing approaches to teach reading, in the EFL contexts. Eye tracking results, hand in hand with the think-aloud protocols' findings, revealed that the participants utilised global reading strategies more frequently to a statistically significant degree after the strategy instruction. Thus, it was concluded that strategy training was useful for the participants to improve their use of global reading strategies, and a recent technological tool can be purposefully integrated into the data collection procedure of educational research studies. Pedagogical implications on the strategy training for the employment of global reading strategies that would help students improve reading skills need to be given attention by teachers.
- MakaleAçık Erişim2023Scopus SJRQ1Structure-function-guided design of synthetic peptides with anti-infective activity derived from wasp venom
Boaro, Andreia; Ageitos, Lucia; Torres, Marcelo Der Torossian; Blasco, Esther Broset; Oztekin, Sebahat; de la Fuente-nunez, Cesar
Antimicrobial peptides (AMPs) derived from natural toxins and venoms offer a promising alternative source of antibiotics. Here, through structure-function-guided design, we convert two natural AMPs derived from the venom of the solitary eumenine wasp Eu-menes micado into a-helical AMPs with reduced toxicity that kill Gram-negative bacteria in vitro and in a preclinical mouse model. To identify the sequence determinants conferring antimicrobial ac-tivity, an alanine scan screen and strategic single lysine substitutions are made to the amino acid sequence of these natural peptides. These efforts yield a total of 34 synthetic derivatives, including alanine substituted and lysine-substituted sequences with stabilized a-helical structures and increased net positive charge. The resulting lead synthetic peptides kill the Gram-negative pathogens Escheri-chia coli and Pseudomonas aeruginosa (PAO1 and PA14) by rapidly permeabilizing both their outer and cytoplasmic membranes, exhibit anti-infective efficacy in a mouse model by reducing bacte-rial loads by up to three orders of magnitude, and do not readily select for bacterial resistance.
AtıfWoS34OpenAlex39İncele - MakaleAçık Erişim2023Scopus SJRQ1Catecholaminergic and Cholinergic Systems Mediate Beneficial Effect of Vortioxetine on Diabetes-Induced Neuropathic Pain
Turan Yücel, Nazlı; Kandemir, Ümmühan; Üçel, Umut İrfan; Demir Özkay, Ümide; Can, Özgür Devrim
The therapeutic potential of vortioxetine on mechanical hyperalgesia/allodynia was investigated in rats with streptozotocin-induced diabetes, and its possible mechanism of action was elucidated in this study. The obtained findings demonstrated that subacute vortioxetine treatment (5 and 10 mg/kg for 2 weeks) increased the reduced paw-withdrawal thresholds of diabetic rats both in the Randall–Selitto and Dynamic plantar tests. Moreover, the falling latencies of animals did not change in the Rota-rod assessments. These results suggest that vortioxetine administration significantly improved diabetes-induced hyperalgesia and allodynia responses in the rats without affecting their motor coordination. The vortioxetine (5 mg/kg)-induced antihyperalgesic and antiallodynic effects were reversed by AMPT, yohimbine, ICI 118,551, sulpiride and atropine pre-treatments, suggesting the involvement of the catecholaminergic system, α2- and β2-adrenoceptors, D2/3 dopaminergic receptors and cholinergic muscarinic receptors in the exhibited pharmacological activity, respectively. Moreover, the data from the immunohistochemical studies indicated that the inhibition of c-Fos overexpression in dorsal horn neurons also mediates the beneficial effect of this drug. Vortioxetine induced no difference in plasma glucose levels in diabetic rats. If clinical studies confirm these findings, the concomitant beneficial effect of vortioxetine on mood disorders and its neutral activity profile on glycemic control may make it an alternative drug for the treatment of neuropathic pain.
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