Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Cuce, Erdem(6)
- Arslaner, Ayla(5)
- Öztekin, Sebahat(5)
- Kutlu, Naciye(4)
- Cuce, Pinar Mert(3)
- Doğan, Zeki(3)
- Erdogan, Ummugulsum(3)
- Hintistan, Sevilay(3)
- Kalyoncuo, Servet(3)
- Kaya, Metin(3)
- Kothakota, Anjineyulu(3)
- Kumar, Manoj(3)
- Pandiselvam, R.(3)
- Sahni, Prashant(3)
- Yavuz, Mehmet(3)
- Acar, Adalet(2)
- Adal, Samiye(2)
- Bozkurt, Aras(2)
- Bulut, Mehmet(2)
- Calina, Daniela(2)
- Cebeci, Fatma(2)
- Colak, Murat(2)
- Daştan, Buket(2)
- Dertli, Enes(2)
- Devecioglu, Dilara(2)
- Durmuş, İbrahim(2)
- Gökçe, H. S.(2)
- Güzel, Ferdi(2)
- Kamiloglu, Aybike(2)
- Karakas, Ümıt(2)
- Karbancioglu-Guler, Funda(2)
- Kayalı, Bünyami(2)
- Lorenzo, José Manuel(2)
- Oztekin, Sebahat(2)
- Pandiselvam, Ravi(2)
- Ramniwas, Seema(2)
- Rustagi, Sarvesh(2)
- Saka, Irem(2)
- Sharifi-Rad, Javad(2)
- Sharopov, Farukh(2)
Yayınlar
- Derleme MakaleAçık Erişim2026İlaç Atıklarının Çevreye ve Halk Sağlığına Etkileri, Geri Dönüşümü ve Mevzuat Çerçevesi
Karakas, Ümıt; Yönten, Eda; Baykara, Gülbahar; Çiydem, Zeynep; Yaramış, Esra; Muhcu, Merve Merve; Çekiç, Nurdane; Edanur; Özkan, Emre; Sultan
İlaç atıkları, hem çevresel ekosistemler hem de halk sağlığı üzerinde ciddi tehditler oluşturan, yönetimi özel önlemler gerektiren tehlikeli atıklar arasında yer almaktadır. Kullanım süresi geçmiş, yanlış saklama koşullarına maruz kalmış, fazla reçete edilmiş veya tedavi değişikliği nedeniyle atıl duruma gelmiş ilaçlar; su, toprak ve hava kirliliğine yol açarak biyoçeşitliliği olumsuz etkilemektedir. Ayrıca antibiyotik kalıntılarının çevreye kontrolsüz salınımı, mikroorganizmalarda direnç gelişimine neden olarak küresel bir sağlık sorununa dönüşmektedir. Bu çalışma, önlisans öğrencileri ile düzenlenen panel çıktılarından ve literatür taramasından elde edilen veriler ışığında; ilaç atıklarının çevresel ve halk sağlığına etkilerini, geri dönüşüm ve sürdürülebilirlik uygulamalarını ve Türkiye ile dünyadaki mevcut mevzuat durumunu ortaya koymaktadır. Bulgular, Türkiye’de ilaç atıklarına özgü bir yasal düzenlemenin bulunmadığını, mevcut mevzuat hükümlerinin farklı yönetmelikler içinde dağınık şekilde yer aldığını göstermektedir. Sonuç olarak, ilaç atıklarının etkili yönetimi için mevzuat bütünlüğü sağlanmalı, geri dönüşüm altyapısı güçlendirilmeli ve toplum düzeyinde farkındalık artırıcı programlar yaygınlaştırılmalıdır.
- Derleme MakaleAçık Erişim2026The Conception of Sunnism and Debates on Sectarian Identity in Farīd al-Dīn ʿAṭṭār’s Manṭiq al-Ṭayr
Sever, Mehmet
This study examines the life, works, and, in particular, the sectarian identity of Farid al-Din Attar, one of the most influential figures of thirteenth-century Islamic thought and Sufi literature, whose affiliation has long been debated in academic scholarship. Attar’s sectarian belonging has become open to speculation primarily through works such as Mazhar al-Ajaib and Heaft Vadi, which were attributed to him by Shi‘i biographical writers but have been shown by modern research to be apocryphal. Although these claims are generally grounded in the pronounced devotion to the Ahl al-Bayt and the gnostic attachment to Ali evident in Attar’s writings, Mantiq al-Tayr, regarded as his principal masterpiece, provides doctrinal clarity with respect to these debates. The article offers a detailed analysis of the eulogies composed by Attar for the Four Caliphs (the Rightly Guided Caliphs) in the preface of Mantiq al-Tayr. While portraying Abu Bakr as the center of loyalty and Sufi spiritual authority, Umar as the criterion of justice and truth, Uthman as a source in which modesty and knowledge converge, and Ali as the gate of spiritual authority and gnosis, Attar remains faithful to the hierarchical and historical framework of legitimacy upheld by the Sunni Islamic tradition. His understanding of Sunnism is not confined to a narrow juridical framework; rather, it is grounded in a gnostic perspective shaped by the Khurasan-Nishapur milieu, one that places devotion to the Ahl al-Bayt at its core and reconciles the concept of spiritual authority with Sunni creed. As a result, the study demonstrates that although Attar employs a suprasectarian language, he emerges as one of the most significant representatives of the Sunni Sufi paradigm at the level of fundamental belief.
- Derleme MakaleAçık Erişim2026Hemodiyaliz Hastalarında Konstipasyon Yönetimi ve Akupresür Uygulaması
Kalyoncuo, Servet
Konstipasyon, hemodiyaliz hastalarının yaşadığı semptomlardan birisidir. Konstipasyon tedavi edilmediği takdirde, karın ağrısı, bulantı, kusma, psikolojik rahatsızlıklar, bağırsak tıkanması ve perforasyonu gibi rahatsız edici belirtilere veya yaşamı tehdit edici komplikasyonlara yol açabilmektedir. Konstipasyon için yaygın farmakolojik müdahalelerin kullanımı kısa süreli semptomların hafifletilmesinde etkili olsa da uzun süreli kullanımları ciddi yan etkilere ve sağlık bakım sisteminde yüksek maliyetlere neden olabilmektedir. Bu nedenle hemodiyaliz hastalarında görülen konstipasyonu hafifletmek için diğer destekleyici yöntemlere de ihtiyaç duyulmaktadır. Son zamanlarda, tamamlayıcı ve alternatif tıp uygulamaları semptom yönetiminde yaygın olarak kullanılmaktadır. Tamamlayıcı ve alternatif tedavi yöntemlerinden biri olan akupresürün konstipasyon yönetiminde etkili olduğu yapılan çalışmalarda gösterilmiştir. Akupresür, vücuttaki belirli akupunktur noktalarına el ile uygulanan basınç uygulamasıdır ve bu uygulamanın insan vücudundaki dengeyi geri kazandırdığına inanılmaktadır. Akupresür, konstipasyon için non-invaziv bir müdahaledir ve herhangi bir ağrı ve yan etki ile sonuçlanmayan etkili bir yöntemdir. Bununla birlikte, hemodiyaliz hastalarında konstipasyonun tedavisinde akupresürün etkileri ile ilgili çalışma sayısı oldukça sınırlıdır. Hemşireler konstipasyon semptomu yönetiminde, tamamlayıcı ve alternatif yöntemlerden biri olan akupresüre ilişkin bilgi sahibi olmalı, hastayı bilgilendirmeli, akupresür uygulamasının hasta üzerindeki etkilerini gözlemlemelidir.
- Derleme MakaleAçık Erişim2026Scopus SJRQ1Functional and Technological Roles of Limosilactobacillus reuteri and Its Critical Metabolites in Food Systems
Yildirim, Sema Nur; İspirli, Hümeyra; Dertli, Enes
Limosilactobacillus reuteri is a lactic acid bacteria (LAB) recognized for its significant technological and functional properties. This species produces diverse metabolites, including reuterin, exopolysaccharides (EPSs), B-group vitamins, short-chain fatty acids (SCFAs), and bioactive peptides, which benefit food systems and host health. However, high strain-specificity and metabolite complexity present challenges in elucidating precise mechanisms of action of these metabolites for their functional and technological roles. This review provides a comprehensive perspective on the latest applications of Lmb. reuteri and its metabolites in food technology by focusing on its utilization in diverse matrices, including dairy, plant-based products, supplements, and edible packaging systems, where it serves to extend shelf life, enhance nutritional profiles, and improve sensory attributes. The strain-specific nature of Lmb. reuteri allows for tailored applications to meet technological requirements. As consumer demand for clean-label and health-promoting foods increases, Lmb. reuteri stands out as a critical LAB species, for the development of next-generation functional foods and preservation strategies. Understanding the potential roles of this species in human and animal health and food safety will help us to build a roadmap for future research and industrial implementation.
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İncele - Derleme MakaleYalnız künye2026Scopus SJRQ1The Potential Neuroprotective Role of Biotin in Neurorehabilitation: A Review
Gunay, Esra; Gezmen-Karadag, Makbule
Purpose of Review: Biotin is a water-soluble vitamin that mammals cannot synthesize and must obtain from the diet. Beyond its established role as a cofactor for biotin-dependent carboxylases, biotin has attracted neurological interest because intermediary metabolism, lipid handling, and myelin maintenance are biologically linked. This narrative review examines biotin across three distinct exposure contexts—nutritional adequacy, functional insufficiency, and pharmacological supplementation—and evaluates its putative relevance to neuroprotection and neurorecovery-oriented processes. Recent Findings: Dietary biotin intake is generally sufficient in mixed diets, and overt deficiency is uncommon; however, low diet quality, reduced bioavailability, and methodological limitations in status assessment may complicate interpretation of biotin sufficiency in clinical nutrition. No validated gold-standard biomarker is currently available. Experimental studies suggest that biotin may modulate pathways related to cellular bioenergetics, lipid metabolism, and myelin-associated processes, but these findings are predominantly preclinical and should not be interpreted as direct evidence of clinical efficacy. In progressive multiple sclerosis, high-dose biotin has been evaluated in human studies, including randomized trials, yet clinical results remain inconsistent and laboratory assay interference remains a relevant practical limitation. Summary: Current evidence does not support conflating adequate dietary biotin intake with pharmacological high-dose exposure. Although biotin remains mechanistically plausible in neuroenergetics and myelin-related disorders, its therapeutic relevance to neurorecovery remains uncertain. Better-designed studies are needed to refine exposure assessment, define dose–response relationships, and determine whether mechanistic signals translate into meaningful clinical benefit.
- Derleme MakaleAçık Erişim2026Scopus SJRQ1Relationships between problematic social media use and social comparison: a meta-analysis
Demir, Mustafa; Yayla, İbrahim Erdoğan; Kaya, Metin; Koçak, Lokman; Arpaci, Ibrahim; Baloglu, Mustafa
We examined the relationship between problematic social media use (PSMU) and social comparison via a meta-analysis. We conducted a systematic literature review and meta-analysis. The study includes quantitative data from 20 independent studies published between January 2019 and October 2025 that examined the relationship between PSMU and social comparison. The studies encompassed adolescents, university students, and the general adult population from both individualistic and collectivist cultural contexts. Effect sizes were calculated using Fisher’s z-transformation under a random-effects model. The results indicated a modest positive relationship between PSMU and social comparison, with an effect size (ES) of 0.24 (95% CI [0.13, 0.36]). Following the Trim-and-Fill adjustment, the effect size decreased slightly, but the overall pattern was preserved. Additional meta-analyses based on standardized regression coefficients showed that, when control variables were included, the association weakened but remained detectable (ES = 0.169, 95% CI [0.029, 0.309]). Effect sizes in unpublished studies were close to zero; however, this finding should be interpreted with caution, as it is based on a limited number of unpublished studies. A high degree of heterogeneity was observed across the analyses. Moderation and meta-regression analyses indicated that the relationship may vary depending on the type of social comparison scale, age, gender composition, and countries’ Global Innovation Index scores. Studies using theory-based measures of social comparison reported higher effect sizes. Higher effect estimates were observed in samples comprising older participants, in groups with a greater proportion of men, and in countries with lower levels of national innovation. In contrast, effect estimates in adolescent samples were relatively small and, in some subgroup analyses, remained trivial despite reaching statistical significance. In conclusion, social comparison shows a limited, context-sensitive relationship in magnitude rather than a strong or universal one with PSMU. However, it is unclear whether the observed relationship reflects a genuine connection between the independent constructs or partial conceptual overlap between the measurement instruments. The findings suggest that, although some sub-group effects may be statistically significant, their practical importance may remain limited. Therefore, the relationship between PSMU and social comparison should be evaluated within a multi-layered theoretical framework that accounts for measurement approaches, socio-technical contexts, and potential conceptual overlaps between constructs.
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İncele - Derleme MakaleAçık Erişim2026Scopus SJRQ2From Technology Adoption to Organizational Governance: Mapping the Intellectual Structure and Shifting Paradigms of AI Governance in Educational Leadership
Kayalı, Bünyami; Yavuz, Mehmet; Bozkurt, Aras
This study maps the intellectual structure and thematic evolution of the intersection between artificial intelligence (AI) and educational leadership in related literature. Employing a hybrid research design that integrates bibliometric analysis with Latent Dirichlet Allocation (LDA)-based topic modeling, we examined 757 unique records retrieved from the Web of Science and Scopus databases for the period 2017–2026. Through computational optimization, the corpus was delineated into six emerging research themes that dictate the field’s shifting paradigms: “Digital Leadership & Transformation,” “Teaching & Student Learning,” “AI Acceptance & Self-Efficacy,” “Data Management & Machine Learning,” “School Leadership & Principals,” and “Technical & Computational Fields.” While “Digital Leadership & Transformation” dominates over half of the literature, a sharp proportional decline in “School Leadership & Principals” uncovers a critical structural imbalance between abstract institutional transformation discourse and the actual human agents executing it. Furthermore, a severe underrepresentation of technical, governance, and transparency themes exposes a critical “opaque box” crisis of institutional agency. The study concludes that the field remains theoretically fragmented and calls for an integrated socio-technical framework reconciling leadership governance with the complex realities of AI systems.
- Derleme MakaleAçık Erişim2026Scopus SJRQ1The role of biotics and bioactive compounds in sports injuries: a narrative review
Şahin-Demirci, Kezban; Dal, Nursel; Gönen-Çolak, Buket; Akman, Onur; Raposa, Bence; Ağagündüz, Duygu
Sports injuries affect not just the physical, but also the psychological, social, and professional aspects of athletes’ lives. Preventive strategies, nutrition, and nutritional supplements—especially biotics and bioactive compounds—are crucial for recovery and may help prevent injury recurrence. This review examines biotics and bioactive compounds that may be effective on sports injuries, revealing their potential benefits and safety of use. Using a comparative and interpretive approach, the pertinent literature was thoroughly examined for this review, with a special focus on clinical and preclinical research conducted within the last 5 years. Bioactive compounds and biotics (prebiotics: indigestible substances that support beneficial bacteria; probiotics: live beneficial microorganisms; postbiotics: bioactive microbial metabolites) can improve sports-related injuries by affecting inflammation, mitochondrial function, biogenesis, oxidative stress, and atrophy. Biotics achieve these systemic effects by improving intestinal barrier function and modulating the microbiota. Current literature indicates that some compounds show promise for treating sports injuries, but human study evidence is limited. Animal models provide useful insights for future research. Finally, polyphenolic compounds, amino acids/peptides, and w-3 fatty acids, thanks to their anti-inflammatory and antioxidant properties, can indirectly contribute to muscle regeneration and cell repair, thus supporting the recovery process in athletes. However, it is still too early to make recommendations regarding the use of biotics and bioactive compounds in sports injuries.
- Derleme MakaleAçık Erişim2026Scopus SJRQ1A Meta-Analysis of Self-Management Strategies to Enhance Educators’ Teaching Performance
Aydin, Orhan; Ari-Arat, Ceren; Sulu, Mehmet D.
This meta-analysis examines the effectiveness of self-management strategies in enhancing the teaching performance of educators, with a focus on special education contexts. Thirty-six studies, including peer-reviewed articles and gray literature, were evaluated for methodological rigor using the What Works Clearinghouse (WWC) Design Standards. Of these, 26 studies meeting the standards with or without reservations were further analyzed using descriptive review, meta-analysis, and moderator analysis. Findings revealed self-monitoring is the most frequently used self-management strategy. Among the educators included in the studies, the majority were special education teachers. Effect sizes were calculated using Tau-U for all 26 studies, between-case standardized mean difference (BC-SMD) for 25 studies, and performance-criteria-based effect size (PCES) for 13 studies reporting a mastery criterion. The overall Tau-U indicated a very large effect size of 0.88 (CI95 = [0.74, 1]), and BC-SMD resulted in a large effect size of 0.87 (CI95 = [0.77, 0.98]). The PCES showed an overall effective effect size of 1.15 (CI95 = [1.07, 1.23]). Moderator analysis revealed behavior-specific praise, and fewer years of teaching experience were associated with higher teaching performance effect sizes compared to other relevant categories; however, years of teaching experience and higher teaching performance were positively associated when using BC-SMD calculations. Detailed findings along with corresponding recommendations are discussed. © Hammill Institute on Disabilities 2026. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- Derleme MakaleYalnız künye2026Scopus SJRQ4Touching relief: A complementary path to easing rheumatoid arthritis pain
Kalyoncuo, Servet
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, leading to pain, joint stiffness, and functional impairment. Despite advances in pharmacological treatments, including disease-modifying antirheumatic drugs (DMARDs) and biologic agents, many patients continue to experience residual symptoms that negatively affect quality of life. This review aims to evaluate the potential role of massage therapy as a complementary approach in the management of RA, with a focus on its clinical effects and proposed mechanisms. A structured literature search was conducted in Medline/PubMed, Scopus, and the Directory of Open Access Journals (DOAJ) for studies published up to March 1, 2025. Studies were considered if they included individuals diagnosed with RA, evaluated any form of massage therapy (e.g., Swedish massage, aromatherapy massage, reflexology), and reported clinical or patient-reported outcomes. Both randomized controlled trials and quasi-experimental studies were included, while studies involving non-RA populations or insufficient methodological detail were excluded. However, this review was not designed as a fully systematic review and may be subject to selection bias. The available evidence suggests that massage therapy may be associated with improvements in pain, joint mobility, and patient-reported outcomes in individuals with RA. However, the overall strength of evidence is limited by methodological concerns, including small sample sizes, heterogeneity in intervention protocols, and the frequent lack of appropriate control groups. While some studies report reductions in inflammatory biomarkers such as interleukin-6 (IL-6) and C-reactive protein (CRP), these findings are based on limited evidence and should be interpreted cautiously, particularly in studies where massage therapy is combined with other interventions. Massage therapy may also contribute to psychological well-being by reducing stress and improving overall mental health. Evidence derived from non-RA populations was considered only as supportive background and was not central to the conclusions of this review. Additionally, the potential for publication bias should be acknowledged, as studies with positive findings are more likely to be published. The integration of massage therapy into RA management may benefit from nurse-led approaches; however, variability in practitioner training and the lack of standardized intervention protocols remain important challenges. Future research should prioritize well-designed, adequately powered randomized controlled trials focusing specifically on RA populations, with standardized massage interventions and clearly defined outcome measures.
- Derleme MakaleAçık Erişim2026Scopus SJRQ2SURVEILLANCE OR SUPPORT? A SYSTEMATIC LITERATURE REVIEW OF ARTIFICIAL INTELLIGENCE SUPPORTED PROCTORED ONLINE EXAMS
Ustun, Aysin Gaye; Kayali, Bunyami; Yavuz, Mehmet; Bozkurt, Aras
Proctored online exams have become widespread, especially after COVID-19, increasing exam security and efficiency. In recent years, artificial intelligence developments have increased these systems' importance by expanding their use. Accordingly, this study aims to provide an in-depth understanding of the conceptual structure of artificial intelligence-supported proctored online examination (AI-SPOE) research. Systematic literature review and text mining were used as methods. Thirty-two studies in Scopus and Web of Science databases were analyzed according to the PRISMA technique. While all the studies were examined in the context of content analysis, abstracts and keywords of the relevant studies were analyzed by text mining. The current study found it effective in increasing academic integrity and exam security, but problems such as privacy violations, exam anxiety, and algorithmic biases were encountered. Although methods such as biometric verification and behaviour analysis successfully detect cheating, technical difficulties, and false positives negatively affect the user experience. In the future, more inclusive designs, transparent algorithms, and alternative evaluation methods are suggested. In conclusion, the study emphasizes the potential of AI-SPOE systems and highlights the importance of ethical and technical improvements.
AtıfScopus1OpenAlex1İncele - Derleme MakaleAçık Erişim2026Scopus SJRQ1Artificial Intelligence Supported Online Assessment and Evaluation in Higher Education: A Systematic Review With SWOT Analysis
Üstün, Ayşin Gaye; Kayalı, Bünyami; Yavuz, Mehmet
Artificial intelligence-supported online assessment and evaluation (AI-SOAE) systems have the potential to transform assessment and evaluation processes in higher education; however, there is a need for a comprehensive evaluation of the pedagogical, technical, and ethical dimensions of these systems. In this regard, the study systematically examined the characteristics of AI-SOAE systems within the framework of a SWOT analysis. A systematic literature review method was used in the research. Ninety-eight studies published between 2018 and 2025 in the Web of Science (WoS), Scopus, and Education Resources Information Centre (ERIC) databases were analysed in accordance with PRISMA guidelines. The findings show that the strengths of AI-SOAE systems include personalised feedback, advanced assessment processes, increased efficiency, and data-driven decision support mechanisms. In contrast, technical infrastructure limitations, algorithmic biases, data management issues, and negative user experiences were identified as the weaknesses of the systems. The analysis also reveals that AI-SOAE systems offer significant opportunities in terms of pedagogical transformation, digitalisation, and institutional competitiveness; however, they face threats such as data security, ethical concerns, risks to academic integrity, and limited empirical evidence. Consequently, AI-SOAE systems offer context- and application-dependent potential for supporting assessment and evaluation practices in higher education. Effectively realising this potential depends on strengthening technical infrastructure, managing algorithmic risks, and developing transparent, ethical, and institutional policy frameworks. By synthesising the literature in the field of AI-SOAE in a structured manner, this study provides a comprehensive assessment for researchers, educators, and policymakers. © The Author(s) 2026. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
AtıfScopus1WoS1OpenAlex3İncele - Derleme MakaleAçık Erişim2026Environmental and economic analysis of industrial waste heat recovery with hybrid heat pump application
Kazici, Halil İbrahim; Tozlu, Alperen
Today, increasing energy demands and environmental concerns have made energy efficiency a necessity from both economic and ecological perspectives. High energy consumption in industrial facilities increases costs and raises CO2 emissions. Therefore, waste heat recovery and the use of renewable energy are among the fundamental goals of sustainable production. Energy efficiency is important not only for reducing consumption but also for lowering greenhouse gas emissions, protecting the environment, and strengthening the economics of the business. In this context, heat pump technologies, which extract energy from low-temperature sources and make it reusable, stand out as effective, environmentally friendly, and efficient systems in both heating and cooling applications. In this study, waste heat from a cooling tower generated during the production process in an industrial facility was recovered through a water-source heat pump and integrated into the facility's heating system. The heat pump increased the heat energy by using low-temperature water and reused it in the process. During periods when the waste heat was insufficient, the system was supported by natural gas boilers, thus creating a hybrid operating model between the heat pump and the boiler. As a result of the implementation, natural gas consumption and electricity usage were significantly reduced, leading to lower energy costs and a substantial decrease in CO2 emissions, thereby providing notable environmental benefits. The findings indicate that the proposed system achieves an annual natural gas saving of 6,788,251 kWh and a net financial gain of 5,703,864 TL. Additionally, the payback period of the investment is calculated as 2.41 years, demonstrating the economic feasibility of the system. Overall, this case study highlights that the widespread adoption of hybrid heat pump systems in the industrial sector can make significant contributions to Türkiye’s energy transition and carbon emission goals.
- Derleme MakaleAçık Erişim2026Scopus SJRQ2Titanium and polyetheretherketone for spinal fusion cages: a comparative narrative review of material behavior, structural design, and clinical translation
Hasheminasab; Bazmi, Arian; Hamsianetefagh, Rojin; Tabak, Yasemin; Ashkani, Omid; Mahboubizadeh, Shahram; Colak, Murat; Şensoy, Abdullah Tahir
Cage material selection in spinal fusion requires a trade-off among biological fixation, mechanical compatibility, subsidence resistance, and postoperative imaging. This structured narrative review compares titanium and polyetheretherketone (PEEK) cages across seven domains: osseointegration, modulus matching, endplate load transfer, surface biofunctionality, imaging, additive manufacturing and personalization, and geometry-guided architecture. Peer-reviewed literature indexed in PubMed/MEDLINE, Scopus, and Web of Science was considered from database inception through May 2026, with emphasis on comparative clinical studies, systematic reviews, meta-analyses, and mechanistic studies directly relevant to cage design. Preclinical studies favor porous and additively manufactured titanium for bone–implant integration, but a consistent fusion-rate advantage in anterior cervical discectomy and fusion (ACDF) has not been established. In lumbar surgery, lower subsidence has been reported in selected lateral lumbar interbody fusion cohorts, while results after transforaminal lumbar interbody fusion remain heterogeneous. PEEK retains advantages in radiolucency and intrinsic modulus matching, while surface-modified and porous PEEK can improve biological performance. Subsidence is not determined by chemistry alone; cage footprint, architecture, endplate preparation, fixation, and bone quality remain major modifiers. Current evidence therefore supports procedure and design-specific selection rather than universal replacement of either platform. Long-term comparative data and standardized definitions of fusion and subsidence remain limited.
- Derleme MakaleAçık Erişim2025Lavanta Yağı ve Genetik Etkileşim: Epigenetik Perspektiften Sağlık Üzerine Bir İnceleme
Karakas, Ümıt
Amaç: Lavanta yağı, Lamiaceae ailesinin önemli bir üyesi olan lavanta bitkisinden elde edilen ve çeşitli terapötik etkilerle öne çıkan bir uçucu yağdır. Tarihsel olarak, antik medeniyetlerden günümüze kadar antibakteriyel, antienflamatuar, anksiyolitik, antifungal ve yara iyileştirici özellikleri nedeniyle geniş bir kullanım alanı bulmuştur. Lavanta yağının temel bileşenleri olan linalool ve linalil asetat, sinir sistemi üzerinde yatıştırıcı etkiler gösterirken, inflamasyonu ve oksidatif stresi azaltarak çeşitli kronik hastalıkların tedavisine yardımcı olabilmektedir. Yapılan araştırmalar, lavanta yağının nörolojik bozukluklardan kansere kadar uzanan geniş bir etki spektrumu olduğunu ortaya koymuş, ancak bu etkilerin moleküler düzeyde nasıl gerçekleştiği henüz tam olarak anlaşılmamıştır. Çalışmanın amacı güncel literatürü mikroRNA’lar çerçevesinde derlemektir. Yöntem: Çalışmanın içeriği “Lavanta yağı”, “miRNA”, “epigenetik”, “gen ifadesi” anahtar kelimelerinin kombinasyonları ile PubMed, Google akademik, Web of science ve Science direct veri tabanlarından yapılan taramalarla oluşturulmuştur. Bulgular: Son yıllarda, esansiyel yağların genetik ve epigenetik düzeydeki etkileri üzerinde durulmakta ve miRNA'lar ile olası etkileşimleri incelenmektedir. miRNA'ların gen ekspresyonunun düzenlenmesindeki kritik rolü göz önüne alındığında, lavanta yağının özellikle stres, depresyon ve inflamasyonla ilişkili miRNA'ları etkileyerek genetik mekanizmaları modüle etme potansiyeli büyük bir araştırma alanı olarak karşımıza çıkmaktadır. Ancak, bu alandaki literatür eksikliği dikkat çekmektedir. Lavanta yağının terapötik etkilerinin daha iyi anlaşılması, özellikle miRNA'lar üzerindeki etkilerine odaklanan moleküler çalışmaların artmasıyla mümkün olacaktır. Sonuç: Gelecekteki çalışmalar, lavanta yağının moleküler biyolojideki yerini sağlamlaştırabilir ve klinik kullanımı genişletebilir. Bu doğrultuda, lavanta yağının biyolojik mekanizmalarını aydınlatmak, onu hastalıkların tedavisinde daha etkili bir araç haline getirebilir.
- Derleme MakaleAçık Erişim2025Digitalization and Sustainability Conflict in Society: Waste Culture and Green Consciousness
Kizmaz, Nuran
Sustainability, which is based on the protection of the resources we have within the framework of the global climate crisis, is gaining importance day by day. With the industrial revolution, we see that the daily lives of individuals have become integrated with technology. It is seen that all institutions of society, from communication to economy, from education to politics, have become connected to technology and networks. Thus, the concepts of increasing digitalization and sustainability have become synonymous with each other. In this article, the relationship between the two concepts will be analyzed in a social and environmental context, and their positive and negative aspects will be discussed. This study aims to understand and evaluate the conflict between wasteful culture and green consciousness by addressing the societal implications in the relationship between digitalization and sustainability. By examining how digital technologies have the potential to provide environmental benefits but also how they affect environmental threats such as e-waste, the study aims to reveal the societal consequences arising from this dilemma. Thus, the main question of the research will be tried to be answered whether digitalization provides environmental benefits in line with sustainability goals or deepens the e-waste crisis by triggering a culture of waste. In the research, a literature review will be conducted from qualitative research methods. As a result, inferences will be made on the future potential of sustainable digital technologies by drawing attention to the awareness of the balance between digitalization and green consciousness.
- Derleme MakaleAçık Erişim2025Digital and Entrepreneurial Education Research is a Different Framework
Durmuş, İbrahim
The research aims to provide a conceptual framework to demonstrate the difference between digital and entrepreneurial education and its development, especially for young individuals. For this purpose, a bibliometric analysis method was employed in the literature for digital and entrepreneurial education research. Research data were taken from the WoS database. Authors who have conducted intensive research on the subject in the literature, keywords they frequently emphasize, country addresses, organizations, the most relevant sources, trending topics, and productivity times are included. The most frequently emphasized terms in digital and entrepreneurial education research are ranked as follows, entrepreneurship, education, entrepreneurial, digital, innovation, digitalization, entrepreneurial intention, entrepreneurship education, digital transformation, and higher education. In research on digital and entrepreneurial education, in the network of co-occurrence relationships of the most emphasized words by the authors, it has been found that entrepreneurship, education, digital, entrepreneurial, innovation, technology, business, digitalization, digital technology, university, digital transformation, entrepreneurial intention, entrepreneurial ecosystem, entrepreneurship education, and entrepreneurial orientation have the strongest relationships. The strongest relationships in terms of centrality and density have been understood as between entrepreneurship, education, entrepreneurial, digital, innovation, digitalization, entrepreneurial intention, digital transformation, COVID- 19, and digital entrepreneurship. Inferences and suggestions were made regarding the research results.
- Derleme MakaleAçık Erişim2025A Systematic Review on the Teachers' and Students' Demotivation in EFL Teaching and Learning
Gürlüyer, Meriç; Atmaca, Muhammed
This study aims to understand better the demotivation towards EFL teaching and learning and analyze and synthesize the research studies carried out between March 2017 and December 2022 to illustrate global demotivation. This study's design, which employs the qualitative approach and is based on a systematic, integrative literature review, is descriptive in nature. This study is conducted methodically to create more broadly relevant or generally applicable data on the topic under investigation. Therefore, 57 research articles were chosen for analysis. Document analysis was employed in this study to collect the data. It was found that most participants of these studies encountered demotivation in their English teaching-learning. Their demotivation was affected by the materials, tools, subjects, rules, and community. The results of this study present suggestions for pedagogical implications to impede demotivation among EFL learners. These results may be helpful for researchers to contribute to the existing literature and focus on the areas in which the current research fails to explain.
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İncele - Derleme MakaleYalnız künye2025Diyabetik Nöropatili Hastalarda Ağrı Yönetiminde Refleksoloji Uygulaması
Kalyoncuo, Servet
Diabetes mellitus; sinirleri, pleksusu ve/veya kökleri etkileyen çeşitli akut ve kronik nöropatilere neden olabilen kronik bir hastalıktır. Diyabetik nöropatiler yaşam kalitesinde önemli bir azalmaya yol açan DM’nin en yaygın komplikasyonudur ve diyabet hastalarının yaklaşık yarısını etkilemektedir. Diyabetik nöropatide en sık görülen semptomlardan biri ağrıdır. Nöropatik ağrıda parestezi, disestezi, hiperaljezi, allodini ve hiperpati gibi semptomlar görülür. Bu semptomlar, hastaların yaşam kalitelerini de önemli ölçüde etkilemekte, psikolojik durumlarını tehlikeye atmaktadır. Bu nedenle diyabetik nöropatili hastalarda ağrı semptomunu azaltmaya yönelik farmakolojik girişimlerin yanı sıra nonfarmakalojik girişimlerden yararlanılmaktadır. Non-farmakolojik yöntemlerden biri olan refleksolojinin en yaygın ve etkin uygulama yöntemlerden biri olan ayak refleksolojisi, ayak tabanındaki refleks noktalarına bası yapılması sonucunda vücuttaki organ ve sistemlerin uyarılmasına dayanan yöntemlerinden biri olarak bilinmektedir. Refleksolojinin endorfin teorisine göre ayakta bulunan refleks noktalarına yapılan baskı vücuttaki endorfin salınımını uyarır. Salınan endorfin beyne giden ağrı sinyallerinin sinirsel iletimini engellemekte, kaygı ve ağrı düzeylerini azaltmakta ve bu sayede vücudun kendi kendini iyileştirmesini sağlamaktadır. Diyabetik nöropatili hastalarda ağrı tedavisinde refleksolojinin etkileri ile ilgili çalışma sayısı oldukça sınırlıdır. Bu açıdan, refleksolojinin diyabetik nöropatili hastalarda gelişen ağrıya etkisini tespit etmek için daha fazla çalışmaya ihtiyaç duyulmaktadır. Refleksoloji hemşirelerin bağımsız fonksiyonlarından biri ve hemşirelik bakımının bir parçasıdır. Bu derlemede diyabetik nörpatili hastalarda ağrı yönetimnde refleksoloji kullanımının yararları ve hemşirelikte kullanım alanlarından bahsedilecektir.
- Derleme MakaleYalnız künye2025Matters to be Considered in Inflation Adjustment and Deduction of Research, Development and Design Expenditures
Doğan, Zeki; Zozik, Adalet
Research, development, innovation and de - sign activities carried out in our country for vario- us purposes such as competing in the internatio- nal arena, achieving the desired economic growth rate and ensuring its sustainability, producing, designing and marketing new knowledge and technologies, attracting foreign capital, getting rid of technological dependence, increasing producti- vity and profitability, ensuring the effective use of resources are financially supported by our state. However, the direct capitalization or expensing of research, development and design expenditures in the accounting records also affects whether these expenditures will be subject to inflation ad- justment and the amount of R&D and design de - ductions to be deducted by taxpayers from their declarations. This study provides explanatory information on the inflation adjustment of research, develop- ment and design expenditures and how much of the amounts arising from the adjustment can be deducted by income or corporate taxpayers thro- ugh their declarations.