Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Dertli, Enes(117)
- Kaya, Yunus(51)
- Şahin, Engin(48)
- İspirli, Hümeyra(47)
- Özen, Soner(46)
- Şenay, Volkan(45)
- Pat, Suat(44)
- Can, Zehra(39)
- Bayraktar, Bülent(37)
- Bayram, Sinan(37)
- Korkmaz, Şadan(36)
- Cuce, Erdem(35)
- Ecem Bayram, Nesrin(33)
- Kutlu, Naciye(33)
- Yilmaz, Mustafa Tahsin(32)
- Artar, Musa(31)
- Ertugrul, Mehmet(30)
- Öner, Erdal(30)
- Ayata, Ümit(29)
- Hasar, Ugur Cem(29)
- Esmer, Yusuf(28)
- Mercan, Emin(27)
- Cuce, Pinar Mert(26)
- Özdemir, Akın(25)
- Çolak, Murat(24)
- Bayram, Ozkan(23)
- Kamiloğlu, Aybike(23)
- Sert, Durmuş(22)
- Ayazoglu, Rabil(21)
- Abdioglu, Murat(20)
- Bayram, Nesrin Ecem(20)
- Kadakal, Mahir(20)
- Kara, Yakup(20)
- Kizil, Hamit Emre(20)
- Tozlu, Alperen(20)
- Birinci, Ahmet(19)
- Gerçek, Yusuf Can(19)
- Battal, Fetullah(18)
- Dirican, Ebubekir(18)
- Ergün, Mustafa(18)
Yayınlar
- MakaleAçık Erişim2020Scopus SJRQ3Effects of lactobacillus reuteri e81 added into rations of chukar partridges (Alectoris chukar) fed under heat stress conditions on fattening performance and meat quality
Tekce, Emre; Bayraktar, B.; Aksakal, V.; Dertli, E.; Kamiloğlu, A.; Çinar, K.; Takma, Ç.; Kaya, H.; Gül, M.
This study investigated the effects of the addition of Lactobacillus reuteri E81 (LRE) into rations of chukar partridges (Alectoris chukar) fed under heat stress (HS) conditions on fattening performance and meat quality. This study included 256 chukar partridges aged 1 day. The study comprised an adaptation period of 7 days and a fattening period of 35 days and included 8 different groups with 32 animals in each group. Each group was further divided into four subgroups with eight animals in each subgroup. At the end of the study, the best results in terms of fattening performance in the non-HS groups were obtained in the LRE 600 ppm group and in the HS groups, SLRE 200 ppm had the best effect on average live weight and average live weight increase, whereas SLRE 400 ppm had the best effect on FCR (p<0.05). The analysis of the samples collected from chukar partridges on day 21 showed that, there was no effect on the colour parameters and Thiobarbituric acid reactive substances (TBARS) level in the LRE in the HS and non-HS groups, whereas the meat pH level decreased in the SLRE 400 ppm group (p<0.05). The analysis of the samples collected on day 42 showed that there was no effect on colour parameters in the HS and non-HS groups. TBARS level decreased at the dose of LRE 200 ppm in the non-HS group, and the meat pH level decreased in both HS and non-HS groups (p<0.05).
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İncele - MakaleAçık Erişim2020Scopus SJRQ3The impact of dietary tarragon (Artemisia dracunculus) on serum apelin, brain-derived neurotrophic factor, cardiac troponin concentrations and histopathology of liver tissue in laying hens housed at different stocking densities
Bayraktar, Bulent; Tekce, Emre; Kaya, Hacer; Karaalp, Musa; Turunc, Eylul
Due to its association with several other stress factors (poultry house gases, inadequate ventilation, heat, cold and poor hygiene), the high stocking density is a major stress factor that adversely affects the health and performance of poultry and the quality of the poultry products. Therefore, this experimental study was aimed at analysing the impact of different doses of dietary tarragon (Artemisia dracunculus) on the serum apelin, plasma brain-derived neurotrophic factor (p-BDNF), and cardiac troponin I (cTnI) concentrations, and the correlation between these indicators in laying hens housed at different stocking densities. The aim of this study is to investigate the effects of adding tarragon in different ratios to laying hen rations in the 2ndovulation period on the cTnI, apelin, and BDNF hormone concentrations and the liver histopathology. The experiment was carried out over a period of eight weeks, with 192 Lohman Brown commercial hybrids at 50 weeks of age. Eight groups (four replicates each), composed of laying hens of equal body weight, which were housed at stocking densities of 580 cm2/hen and 810 cm2/hen and received 0, 1, 5 and 10 mmol/kg of tarragon (Artemisia dracunculus) in the feed, were established. At the end of the trial, 96 of the housed egg-laying hens (3 birds in each subgroup, a total of 12 birds in each group) were randomly selected and blood samples were taken from the vena subcutanea ulnaris. The samples collected were analysed for the apelin, p-BDNF, and cTnI contents. The analysis results demonstrated that tarragon supplementation had no effect on the serum apelin, p-BDNF and cTnI concentrations (P > 0.05). The Sub-Groups ST1, ST1.2, and ST6 presented with severe hyperaemia of the sinusoidal, portal and acinar blood vessels, whilst the hyperaemia of these blood vessels was moderate in Sub-Group ST12. Apelin, BDNF, and cTnI can act as protective factors against negative consequences of stress (e.g., stocking density or heat stress).
AtıfScopus5WoS7OpenAlex2İncele - MakaleAçık Erişim2020Scopus SJRQ3Model-based dynamic fractional-order sliding mode controller design for performance analysis and control of a coupled tank liquid-level system
Sekban, Hayriye Tugba; Can, Kaan; Basci, Abdullah
In this paper, a model-based dynamic fractionalorder sliding mode controller (FOSMC) is designed and implemented to a coupled tank experimental setup for controlling the liquid level. First, a model-based dynamic sliding-mode controller is designed by using the dynamic equations of a vertically positioned coupled tank system. Then, the sliding surface of the sliding-mode controller is defined in fractional order so that the designed controller can make better water level tracking. The liquid level control of the system is realized in two different steps. In the first step, the water level of the upper tank is controlled by a pump and in this application the bottom tank is not considered. In the second step, the water level of the bottom tank is controlled with upper tank's output water. In addition, a model-based dynamic sliding mode controller (SMC) is also applied to the system to show the performance of the proposed controller in terms of robustness to disturbances, reference tracking and error elimination capability. Experimental results show that the proposed controller reduces the reference tracking error by 3.68% and 10.17% for the upper tank and 17.07% for the bottom tank when compared to the SMC, and the control signal contains more chattering than the SMC.
AtıfScopus6WoS6OpenAlex6İncele - Kitap BölümüYalnız künye2020Marketing finance, infrastructure, and entrepreneurshi
Kara, Adnan
This chapter examines the relationship between marketing finance, infrastructure, and entrepreneurship. The aim of the study is to show that countries' financial development improves infrastructure, reduces risks, and increases entrepreneurship. Marketing finance is the provision and management of monetary funds in order to carry out marketing activities. Marketing infrastructure is the existence of physical systems such as logistics, advertising agencies and research companies that carry out marketing activities. Marketing entrepreneurship is the transformation of innovative ideas into economic activities in coordination with marketing process management. In conclusion of the study, the development of the financial system affects the competitiveness. Thus, more marketing investments are made in a more competitive environment.
- MakaleYalnız künye2020Scopus SJRQ2Electrical properties of Graphene/Silicon structure with Al2O3 interlayer
Kaymak, Nuriye; Bayram, Ozkan; Tataroğlu, Adem; Bilge Ocak, Sema; Oz Orhan, Elif
The electrical properties of the fabricated Al/Gr/Al2O3/p-Si structure have been analyzed using frequency-dependent capacitance/conductance–voltage (C/G–V) measurements. Graphene (Gr) nanosheets were grown on to copper (Cu) catalyst substrate, which has 99.99% purity, by Chemical Vapor Deposition (CVD) technique, and then the Graphene was transferred on Al2O3/p-Si by the standard transfer process. The Graphene structures have been characterized by Raman Spectroscopy and Transmission Electron Microscopy (TEM) analyses, and the results of both analyses confirmed the monolayer/bilayer Graphene nanostructure. The forward and reverse bias G–V and C–V measurements of this structure have been performed in 10 kHz–400 kHz and at 300 K. The frequency dispersion in C and G can be evaluated for interface state density (Dit) and series resistance (Rs) values. The values of Dit and Rs are dependent on frequency and increase with decreasing frequency. The Rs- V graph shows a peak form at all frequencies in the depletion region and vanishes with increasing frequency. The obtained results suggest that the prepared structure can be used in electronic device applications.
AtıfScopus25WoS23OpenAlex23İncele - MakaleAçık Erişim2020APPLICATION OF VARIATION OF THE PARAMETERS METHOD FOR MICROPOLAR FLOW IN A POROUS CHANNEL
Güngör, Osman; Arslantürk, Cihat
This work devoted to study the injective micropolar flow in a porous channel. The flow is driven by suction or injection on the channel walls, and the micropolar model is used to characterize the working fluid. The governing nonlinear partial differential equations are reduced to the nonlinear ordinary coupled differential equations by using Ber-man’s similarity transformation. These equations are solved for large mass transfer via variation of parameters method (VPM) which has been used effectively in the solution of nonlinear equations recently. This method has not previously been applied to a problem of micropolar flow. The results of the variation of parameters method are found to be in excellent agreement with the results of the Matlab bvp4c solver (NUM). With this validity, the effects of the some important parameters on the velocity and rotation profile of micropolar flow are discussed in detail. It can be seen that increases in the values N1 and N3have different results in comparison with N2 increasing.
AtıfScopus3WoS3OpenAlex4İncele - MakaleYalnız künye2020DYNAMIC BEHAVIOUR OF HISTORICAL BAYBURT GRAND MOSQUE
Yurdakul, Muhammet; Yilmaz, Fatih; Artar, Musa
In this study, the locations of the damages that would occur when a historical building was exposed to different earthquakes were determined. The selected building is Bayburt Ulu Mosque located in the city center of Bayburt and it was built by the Anatolian Seljuk Sultan II. Gıyaseddin. This selected historical building is modelled according to the macro modelling technique in the SAP2000 program using the finite element method. Modules of elasticity, poisson's ratio and weight per unit of volume of Bayburt Stone which is used in the mosque are determined by the experiment. Also, the properties of the ground on which the building was built are determined. As earthquake records which recorded on similar grounds, components of DZC180 and DZC270 of 17 August 1999 Kocaeli earthquake, components BOL000 and BOL090 of 12 November 1999 Düzce earthquake and components of ERZE-EW and ERZE-NS of 13 March 1999 Erzincan earthquake are used. In the results of the dynamic analysis made, quantities and locations of the strains that can occur in the historic mosque are determined.
- MakaleAçık Erişim2020Scopus SJRQ4Investigation of alterations in PIK3CA and OCT-4 gene expression in breast cancer
Dirican, Ebubekir; Kankaya, Burak; Büyükaşık, Süleyman; Alış, Halil; Velidedeoğlu, Mehmet; İlvan, Sennur; İlvan, Ahmet
Breast cancer (BCa) is one of the most prevalent cancer amongst women and PIK3CA mutations have a crucial role in carcinogenesis. On the other hand, Octamer-Binding Transcription Factor 4 (OCT-4) is common biomarkers of cancer stem cells, which provide to the pathological processes of numerous carcinomas. In this study, we evaluated the association of OCT-4 gene expression levels with the PIK3CA mutation in BCa patients. The mRNA expression level of the OCT-4 gene was detected by qPCR in 44 BCa patients and 30 BCa patients control have positive PIK3CA mutations. Exon 9 and exon 20 of PIK3CA mutations were identified by sequencing. OCT-4 gene expression and PIK3CA mutations were also clinically evaluated in BCa patients. The frequency of PIK3CA mutation in 44 new cases were 32%. PIK3CA mutations were significantly associated with HER2-positive (p = 0.0271) status, Ki-67 status (p = 0.0434) and patient age (p = 0.0149). OCT-4 mRNA expression was significantly higher in the BCa tissue in comparison to normal breast tissue (p = 0.0305). A significant correlation was found between expression of OCT-4 and node status (p = 0.0190). OCT-4 mRNA expression was higher in the PIK3CA mutation tissue than the wild type tissue. However, no association was found between the expression of OCT-4 and the PIK3CA mutation or wild type samples (p = 0.7908). Our results provided that OCT-4 gene and PIK3CA mutations may have a role in development of BCa. OCT-4 mRNA expression level and PIK3CA mutations have a potential important for BCa diagnosis or treatment.
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2020Scopus SJRQ2The relationship between housing prices and inflation rate in Turkey: Evidence from panel Konya causality test
Korkmaz, Özge
Purpose: Human beings need shelter as the beginning of their existence. Same holds true for people who live in Turkey as it is a cultural and traditional reason to be the host and endeavor to buy a home even if one has to pay the debt for years. Another factor that is important for individuals and even for countries is the inflation rate. In this context, the purpose of this study is to investigate whether the 26 regions of Turkey are affected by the inflationary pressure, specifically in the housing price index (HPI). Design/methodology/approach: For this purpose, data from 2010:01 to 2019:01 and the consumer price index (CPI), as well as HPI have been used. The causal relationship between the variables is analyzed by Konya Causality (2006) test. Findings: The key results suggest that HPI causes inflationary pressures in some regions. Research limitations/implications: The study has some limitations in terms of data set and scope. These are as follows: although there are many variables affecting housing prices, this study aims to investigate the causal link between inflation and housing prices. In addition, only the CPI and HPI variables were provided on a monthly basis in the 2010-2019 period for 26 regions due to the aim of making regional propositions in the investigation of this relationship. For these reasons, different macroeconomic variables could not be studied. Originality/value: This study makes the following contribution to the literature. While the majority of existing literature investigates the relationship between housing prices and inflation from an empirical perspective for country, very few studies have been for the sub-regions and also these studies have focused on only some sub-regions. In other words, in the literature review, a study has observed that Turkey has to examine the relationship between the housing price and inflation variables for all sub-regions in particular. To overcome this deficiency in the literature, this study aims to investigate the relationship between housing price and inflation for 26 regions.
AtıfScopus24WoS18OpenAlex36İncele - MakaleYalnız künye2020MODELING OF BOOST AND CUK CONVERTERS AND COMPARISON OF THEIR PERFORMANCE IN MPPT
Güngör, Okan; Yüksek, Halil İbrahim
The efficiency of photovoltaic (PV) panel systems depends on the structure of the photovoltaic cells and the transfer of energy from the PV panel to load. The focus of this study is energy transfer. The most important component in the energy transfer is maximum power point tracking (MPPT). The MPPT consists of two components: the algorithm for calculation the maximum power and the hardware for power generating. This study investigates how some the DC-DC converters (hardware) impact on the performance of the MPPT under six different environmental conditions by using two different duty cycle calculation methods. Contribution of this study to the literatüre is to analyze the performance of some the DC-DC converters in MPPT by completely eliminating the effect of MPPT algorithms. As a result of this study, while using the Boost converter in MPPT applications, the internal resistance of the PV panel must be equal or smaller than load resistance. However, the Cuk converter can reach to maximum power point in all conditions such as temperature, radiation and load.
AtıfScopus2İncele - MakaleAçık Erişim2020Scopus SJRQ4Effects of race, gender, body condition score and pregnancy on serum apelin levels in ewe
Bayraktar, Bülent; Tekce, Emre; Aksakal, Vecihi; Takma, Çiğdem; Bayraktar, Fatma Gülten; Şengül, Bülent
Apelin is an important adipokine hormone that is released from adipose tissue, which is considered as the energy store of the body, which plays a role in many physiological processes in the body, as well as cardiovascular, immune functions and energy, nutrients and fluid metabolism. In this study, it was aimed to determine the effect of lactation, pregnancy and gender on apelin hormone levels in blood serums belonging to different races of ewe. In the present study, the hormone levels of the pregnant, non-pregnant ewe and rams of the Akkaraman Kangal and Morkaraman races were thin, with different body condition scores (<2, 3 to 3.5 and ≥4). Apelin hormone level was determined by ELISA technique in blood serum samples of ewe's Jugular vein. It was determined that there was a difference in body scores between races and the interaction between race and body score was important (P<0.05). Apelin level in ewe in lactation and pregnant ewe did not change according to body condition scores (P>0.05). In terms of apelin, gender and body condition score, race and gender, and body condition score interactions were found to be significant.
AtıfScopus6WoS6OpenAlex4TR Dizin2
İncele - MakaleAçık Erişim2020Scopus SJRQ2Superconducting and levitation force characterisation of pyrene added MgB2 bulk superconductors
Erdem, Ozge; Guner, Sait Baris; Celik, Sukru; Kucukomeroglu, Tayfur
This research presents the influence of pyrene (C16H10) addition (0, 2, 4, 6, 8, 10 wt%) on the superconducting properties of bulk MgB2. For C16H10 added MgB2 samples, a shrinkage in a-lattice parameters was determined, whereas c-lattice parameters remained practically unchanged. The (1 1 0) peak observed at 2θ ≈ 59.9◦ slightly shifted to higher angles, the lattice strain increased and the crystallite size reduced after C16H10 addition. By virtue of induced stronger pinning force, the in-field critical current density (Jc) increased after C16H10 addition. The Jc value at 20 K and 4 T was obtained about two times higher (8.54 × 103 A/cm2) for 4 wt% C16H10 added MgB2 sample than that of the pure one. In addition, the variation of levitation force characteristic of MgB2 with increasing C16H10 content was determined at 20, 25 and 30 K. The best vertical levitation force performance in zero-field-cooled regime was obtained as 7.09 N/g at 20 K for 4 wt% C16H10 added MgB2 sample with 13 mm in diameter.
AtıfScopus8WoS6OpenAlex8İncele - MakaleYalnız künye2020Scopus SJRQ2Hand washing in primary school students using “demonstration, puzzle, dance, song”: A nursing project based on multifaceted skills training
Ozcan, Aysegul; Ozdil, Kamuran; Kaya, Senay Sermet; Sezer, Fatma
Background: The effects of an educational strategy, “demonstration, puzzle, dance, song (DPDS),” on the hand washing skills of primary school students was ex-amined. Method: This study used a quasi-experimental, training research format with a pre-and posttest research design and was conducted by a research team from a university department of public health nursing. The study included 671 (90.2%) of 744 students who attended primary schools in Nevsehir, Turkey. Data were collected with a demographic data collection form and a Hand Washing Skills Evaluation List. McNemar, Fried-man, and Wilcoxon tests were used to analyze findings. Results: Immediately after training, all steps of hand washing were performed at higher levels than before training (p < .01), and the difference between hand washing times was significant (p < .001). Conclusion: Hand washing skills and times increased after undergo-ing hand washing training using the DPDS method. [J Contin Educ Nurs. 2020;51(4):158-166.].
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İncele - BildiriYalnız künye2020INVESTIGATION OF THE EFFECTIVENESS OF VISCOUS DAMPERS CONNECTED TO ADJACENT BUILDINGS ON DYNAMIC BEHAVIOR UNDER SOIL-STRUCTURE INTERACTION EFFECTS
Hatıpoğlu, Yavuz Selim; Düzgün, Oğuz Akın
In this study, the dynamic behavior of two adjacent structures with fluid viscous damper (FVD) was investigated under the influence of earthquake and considering soil-structure interaction (SSI). Adjacent structures with FVD’s were analysed for three different soil types. The modelling and analysis were made in two-dimensional (2D) space by using ANSYS package program. Viscous boundary conditions were used on the boundaries of 2D soil model. The analyses results were obtained in terms of displacement, acceleration, and shear force. The effect of FVD was investigated using different connection types. The damping coefficient of FVD’s was assumed constant in all analyses. When the results of the analysis are examined, it can be seen that FVD’s are effective for seismic response. However, it is necessary to consider the soil-structure interaction. Significant different structural results were obtained between fixed support and three different soil types. For example, in the same model, while the top floor displacement may reduce in Soil Type I, the top floor displacement may increase in Soil Type II. At the end of the study, it was seen that there was no need to connect the FVD to all floors. It was found sufficient to connect a fluid viscous damper only to the top floor (1 FVD) or to the top and middle floor (2 FVD). FVD’s have no effect on buildings with the similar dynamic character. In the analysis for seismic control of adjacent buildings, the effect of soil-structure interaction should certainly be taken into account.
AtıfScopus3İncele - MakaleAçık Erişim2020Scopus SJRQ3Development of a primary school teacher on the philosophy with children: An action research*
Boyraz, Celal; Türkcan, Burçin
This study aims at providing a detailed description of the ways to understand the development process of a primary school teacher on philosophy with children (PwC) approach. Action research was used as the research method since the problems determined in the current study can be iteratively solved with the development of the teacher. The study group consists of a teacher in a primary school located at the center of Bayburt, Turkey in the 2018-2019 academic year and 20 third-grade students. Qualitative data collection methods; observation, interview, field notes and diaries were used. A systematic analytical method was applied and the data were analyzed using a content analysis approach. The primary school teacher was provided with training on the PwC approach and eight action cycles were conducted regarding the implementation of this approach. Observations and interviews conducted in this process indicated that there are developments in the teacher in implementing the PwC approach and these developments positively affect some skills of the students. Based on the findings obtained in the current study, the authors made some recommendations for practice and future studies.
AtıfScopus2OpenAlex3İncele - MakaleAçık Erişim2020Scopus SJRQ2Bellevalia bayburtensis (Asparagaceae): a new species from northeastern Anatolia, Turkey
Yildirim, Hasan; Sefali, Abdurrahman
Bellevalia bayburtensis (Asparagaceae) is described and illustrated as a new species from Bayburt Province in northeastern Anatolia, Turkey. Diagnostic morphological characters, a full description, detailed illustrations, and a distribution map are provided. It is morphologically similar to B. rixii and B. paradoxa, but clearly differs from these species by the leaf shape, the bud and flower colour.
AtıfScopus6WoS5OpenAlex5İncele - MakaleAçık Erişim2020Scopus SJRQ2Characterization of pediococcus acidilactici PFC69 and lactococcus lactis PFC77 bacteriocins and their antimicrobial activities in tarhana fermentation
Kaya, Halil İbrahim; Şimşek, Ömer
Tarhana is a traditional cereal product fermented by lactic acid bacteria (LAB) and yeast strains that has gained special interest recently as an infant nutrition. Tarhana contains wheat flour, yogurt, and various vegetables that might create a microbiological toxicological risk, especially for Bacillus cereus and Staphylococcus aureus. In this study, characterization of the metabolites responsible for antibacterial activity of Pediococcus acidilactici PFC69 and Lactococcus lactis PFC77 strains obtained from tarhana was performed, and antibacterial effects were detected against B. cereus ATCC 11778 and S. aureus ATCC 29213 during the fermentation. A total of 12,800 AU/mL antibacterial activity was observed for the supernatants of the PFC69 and PFC77 strains that were found to be stable at high temperature and in low pH conditions and sensitive to proteases, suggesting the antimicrobial metabolite is a bacteriocin. These bacteriocins were further purified and their molecular sizes were determined as 4.5 and 3.5 kDa, respectively. Importantly, inoculation of PFC69 and PFC77 to tarhana dough significantly decreased B. cereus ATCC 11778 and S. aureus ATCC 29213 amounts from the fifth day of fermentation compared to the control dough samples. P. acidilactici PFC69 and L. lactis PFC77 strains were concluded as bioprotective cultures for tarhana and these strains were offered for other cereal-based fermentations.
AtıfScopus29WoS25OpenAlex33İncele - MakaleYalnız künye2020Scopus SJRQ3An analysis of the role of the social acceptance of University Students' bicycle use in sustainable urban development when epidemics spread
Saatchian, Vahid; Azimkhani, Amin; Honari, Habib; Türkmen, Mutlu
The purpose of this study was to investigate the role of the acceptance of university students' bicycle use in sustainable urban development in Iran when epidemics spread. The research method was descriptivecorrelational, and the investigation was carried out as a field study. The statistical population of the study consisted of university students, 254 of whom were selected by a simple random sampling method to participate in the research. The research instrument was a questionnaire based on the Sustainable Development with a reliability coefficient of 0.83; the social acceptance component was based on the theory of planned behaviour with a reliability coefficient of 0.8. As the results of the investigation have demonstrated, the bicycle plays a significant role in the development of the socialization process of people, and there is a positive and significant relationship between social acceptance and sustainable development (p<0.05). Furthermore, 20% of sustainable development change was achieved through the dimensions of social acceptance (planned behaviour theory). Finally, it can be argued that perceived behaviour in social acceptance is most likely to play a significant role in the emergence of sustainable development by external factors such as encouragements and persuasion of the family, important people, friends, acquaintances, and even by the existing norms in society. Subsequently, as people change their mindset when epidemics spread, they can turn all the behaviours they manifest in their leisure time into a culture development movement.
- MakaleAçık Erişim2020Scopus SJRQ3Bio-catalytic asymmetric synthesis of β-adrenergic receptor blocker precursor: (R)-2-bromo-1-(naphthalen-2-yl)ethanol
Taşdemir, Volkan; Kalay, Erbay; Dertli, Enes; Şahin, Engin
Aromatic α-halohydrins, particularly 2-haloethanols as significant precursor of drugs, can easily be converted to chiral β-adrenergic receptor blockers. Eight strains of Lactobacillus curvatus were tested as biocatalysts for asymmetric reduction of 2-bromo-1-(naphthalen-2-yl)ethanone 1 to 2-bromo-1- (naphthalen-2-yl) ethanol 2. The parameters of the bioreduction were optimized using L. curvatus N4, the best biocatalyst found. As a result, (R)-2-bromo-1-(naphthalen-2-yl)ethanol 2, which can be β-adrenergic receptor blocker precursor, was produced for the first time in high yield and enantiomerically pure form using biocatalysts. Moreover, the gram scale synthesis was performed and 7.54 g of (R)-2 was synthesized as enantiopure form (enantiomeric excess >99%) in 48 h. The important advantages of this process are that it produces of (R)-2 for the first time in enantiopure form, in excellent yield and under environmentally friendly and moderate reaction conditions. This system is of the potential to be applied at a commercial scale.
AtıfScopus2WoS2OpenAlex2İncele - MakaleYalnız künye2020Scopus SJRQ1Current–voltage analyses of Graphene-based structure onto Al2O3/p-Si using various methods
Efil, Esra; Kaymak, Nuriye; Seven, Elanur; Orhan, Elif Oz; Bayram, Ozkan; Ocak, Sema Bilge; Tataroglu, Adem
The present study's main purpose is to determine the current-voltage (I–V) performance of Graphene (Gr) based hetero nanostructure produced on Al2O3/p-Si. Graphene synthesis was carried out using the chemical vapor deposition (CVD) technique on Copper (Cu) foils used as a metal catalyst and transferred onto Al2O3/p-Si using the conventional transfer method. The I–V characteristics of this structure were measured in the dark environment, and the electrical properties of the Gr/Si structure were characterized at room temperature. The rectifying ratio (RR) of the structure was found to be about 103 at ± 3 V. The electrical properties of ideality factor (n), series resistance (Rs), and barrier height (Φb) were examined by using the theory of Thermionic Emission (TE), Norde's method, and Cheung's method. The values of Φb, which were calculated using Norde's method, Cheung's method, and the theory of thermionic emission (TE), were found to be 0.69 eV, 0.71 eV, and 0.68 eV, respectively. The ideality factor was found to be approximately 3.89 according to the theory of TE. The values of series resistance were also determined using the Norde's method and Cheung's two different parameters (dV/dln(I) and H(I)) found to be 9.60 kΩ, 9.12 kΩ, and 5.94 kΩ, respectively.
AtıfScopus25WoS25OpenAlex26İncele