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- MakaleYalnız künye2023Scopus SJRQ1Parameter extraction method for reflection-asymmetric bianisotropic metamaterial slabs using one-port measurements
Hasar, Ugur Cem; Kaya, Yunus; Ozturk, Hamdullah; Ertugrul, Mehmet; Ramahi, Omar Mustafa
An effective microwave method is developed for extracting electromagnetic properties of bianisotropic metamaterial (MM) slabs. As a non-iterative method, it utilizes only the one-port (air-backed and metal-backed MM slab) scattering (S-) parameter measurements. This is a useful feature especially for vector network analyzers, such as MS46131A, MS46121B, and R60, performing only one-port S-parameter measurements. Electromagnetic properties of a bianisotropic MM slab formed by C-shaped resonators are measured by an X-band (8.2–12.4 GHz) rectangular waveguide setup. The effect of any gap between the short-circuit termination for metal-backed measurements and the end of the MM slab on extracted electromagnetic properties is also examined for evaluating the possible error for proposed method.
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İncele - MakaleAçık Erişim2023Scopus SJRQ2Suberosin Alleviates Sepsis-Induced Lung Injury in A Rat Model of Cecal Ligation and Puncture
Karabulut Uzunçakmak, Sevgi; Halıcı, Zekai; Karakaya, Songül; Kutlu, Zerrin; Sağlam, Yavuz Selim; Bolat, İsmail; Aydın, Pelin; Kılıç, Ceyda Sibel
Background/aims: Sepsis is one of the major problems encountered in intensive care units, causing organ damage and increasing mortality. Suberosin (SBR) is a type of coumarin with antioxidant and anti-inflammatory activities. The goal of this study is to explore the protective effects of SBR on the lungs in a rat model of sepsis. Methods: Male Wistar rats were utilized in this study. A cecal ligation and puncture (CLP) model was applied to induce sepsis. Rats were separated into six groups with nine animals in each group, including healthy control, SBR, CLP, and CLP + SBR (5, 10, and 20 mg/kg) groups. Superoxide dismutase (SOD), glutathione (GSH) enzyme activities, and malondialdehyde (MDA) level were measured via enzyme-linked immunosorbent assay (ELISA). The messenger RNA (mRNA) expressions of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) were evaluated by real-time polymerase chain reaction (RT-PCR). Histopathological changes in the lungs were investigated with hematoxylin and eosin (H&E). Results: MDA levels and GSH and SOD enzyme activities were negatively affected in the CLP group, but SBR treatment ameliorated these oxidative stress parameters in the SBR1-3 groups (p< 0.05). The mRNA expressions of TNF-α and IL-1β were increased in the CLP group, and SBR treatment decreased those expression levels in a dose-dependent manner (p < 0.05). Organ damage and necrosis were seen in the CLP group and were alleviated in the SBR3 group. Immunohistochemical (IHC) analysis of lung tissues demonstrated decreased TNF-α and IL-1β immunopositivity in the SBR1-3 groups (p< 0.05). Conclusions: SBR ameliorated sepsis-related lung injury in a dose-dependent manner. This compound has significant potential as a future agent in the treatment of sepsis.
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İncele - Derleme MakaleAçık Erişim2024Scopus SJRQ3Psychological Aspects of Behavioral Disorders in Management
Durmuş, Ibrahim
In today's organizations, working environments direct the work activities of all employees. The psychological aspects of behavioral disorders that employees may exhibit in organizational management constitute the main problem of the research. With the help of the Web of Science database, research on the psychological aspects of behavioral disorders in management were examined on a global scale. The bibliometric analysis method was applied to the obtained data using R and R Studio software. Research on the psychological aspects of conduct disorder in management; was conducted from 1994-2023 and 229 sources. The annual growth rate of research is 2.42%. The number of research conducted on the subject reached maximum levels in 2020 and the number of citations in 2002. Contributing the most to the subject; author, Davis, journal, AIDS Care-Psychological and Socio-Medical Aspect of AIDS/HIV, country, USA, keywords therapy and depression, and the University of Washington. Some of the keywords that authors focused on the most in their research; depression, anxiety, treatment, chronic pain, HIV, Covid-19, psychotherapy, quality of life, managing, stress, psychological, and adolescents. The strongest relationship among the concepts related to the subject was between depression and anxiety. In recent years, the idea of depression has been emphasized the most. In terms of the psychological aspect of behavioral disorder in management, the strongest relationships were between the concepts of "depression, anxiety, HIV, psychotherapy, pain, sleep, cognitive behavioral therapy, mental health, and therapy". The conclusion reached by using the literature was that individuals should be healthy both biologically and psychologically in their organizational activities.
- MakaleAçık Erişim2024Scopus SJRQ1Evaluation of nurses’ attitudes and behaviors regarding narcotic drug safety and addiction: a descriptive cross-sectional study
Kaya, Ayten; Kirbaş, Zila Özlem; Medin, Suhule Tepe
Background: By evaluating nurses’ attitudes and behaviors regarding narcotic drug safety and addiction, effective strategies need to be developed for combating addiction in healthcare institutions. This study, aimed at providing an insight into patient and staff safety issues through the formulation of health policies, aimed to evaluate nurses’ attitudes and behaviors regarding narcotic drug safety and addiction. Methods: The study was conducted in a descriptive cross-sectional design. It was carried out with 191 nurses in a public hospital between March 2023 and August 2023. Data were collected through face-to-face interviews, gathering socio-demographic information and utilizing the Addictive Substance Attitude Scale. The data were analyzed using independent sample t-tests, one-way ANOVA tests, and regression analysis (P <.001 and p <.05). Results: The average age of the participants was determined to be 36.58 ± 8.40. It was reported by 85.3% of nurses that narcotic drug follow-ups in their units were conducted according to procedures. In the study, it was found that 63.9% of nurses did not know the procedure to be followed towards a healthcare professional identified as a narcotic substance addict. The total mean score of the Addictive Substance Attitude Scale of nurses participating in the study was 74.27 ± 14.70. A significant difference was found between the total scores of the scale and the level of education of nurses, the follow-up status of the drugs in the unit where they work, their status of receiving narcotic drug addiction training, and their routine use of the half-dose drug disposal form (p <.05). Conclusions: The findings of this study underscore the importance of evaluating nurses’ attitudes and behaviors regarding narcotic drug safety and addiction. These results indicate the need for nursing administrators, particularly in terms of patient and staff safety, to adopt more effective policies and strategies.
AtıfScopus1WoS1OpenAlex3İncele - Kitap BölümüAçık Erişim2025Lipid-protein interactions in food systems: Mechanisms, thermodynamics, and analytical approaches
Öztekin, Sebahat; Uzun, Suzan; Köroğlu, Deniz Günal; Bilgin, Ayşenur Betül; Gökşen, Gülden
This chapter provides a comprehensive overview of lipid-protein interactions in food systems, focusing on their physicochemical mechanisms, analytical techniques, and implications for food quality, nutrition, and functionality. These interactions, governed by hydrophobic, electrostatic, hydrogen bonding, and van der Waals forces, are influenced by multiple factors such as pH, temperature, and ionic strength during food processing. Both experimental techniques, including spectroscopy (fluorescence, CD, FTIR), calorimetry (ITC, DSC), microscopy (CLSM, SEM), and gel electrophoresis, as well as computational approaches such as molecular dynamics simulations and molecular docking are used to characterize the structural, thermodynamic, and dynamic properties of these interactions. Lipid-protein interactions affect key lipid characteristics such as chemical stability, solubility, and gastrointestinal behavior, while also modulating protein properties like digestibility, thermal stability, gelling, foaming capacity, phosphorylation, and aggregation. Moreover, these interactions can influence health-related outcomes, including lipid oxidation, cholesterol metabolism, and allergenicity. Understanding these interactions provides valuable insights for the development of novel and functional food products with enhanced stability and bioavailability. The dynamic nature of lipid-protein interactions necessitates continued research using integrated experimental and computational approaches to optimize their role in modern food systems.
- MakaleAçık Erişim2024Scopus SJRQ4Beyond Tradition: Jamāl al-Dīn al-Afghānī’s (1838-1897) Impact on Contemporary Qur’ānic Exegesis
Aras, Zakir
This article examines the understanding of Qur’ānic exegesis before Jamāl al-Dīn al-Afghānī and the innovative approaches he introduced. Using an inductive method, it analyses Jamāl al-Dīn al-Afghani’s books, articles, and speeches. Before al-Afghānī, Qur’ānic exegesis was dominated by classical methods focused on syntax, grammar, jurisprudence, and theology, failing to meet contemporary needs. Al-Afghānī did not write a tafsīr book in the classical style but his articles in al-ʿUrwah al-Wuthqā resemble independent exegesis treatises, following a late Ottoman style. He advocated for a subjective and critical reading, centring only on the Qur’ān and rejecting linguistically focused exegesis. He emphasized the Qur’ān’s relevance to contemporary issues, highlighting its social, cultural, anthropological, and political messages. On the topic of mu‘arrab, however, he made forced comments without sufficient evidence.
AtıfScopus2OpenAlex1İncele - MakaleYalnız künye2022Scopus SJRQ1Bioactive compounds of deep eutectic solvents extracts of Hypericum perforatum L.: Polyphenolic- organic acid profile by LC-MS/MS and pharmaceutical activity
Bayram, Sinan; Kutlu, Naciye; Gerçek, Yusuf Can; Çelik, Saffet; Ecem Bayram, Nesrin
Deep eutectic solvents (DESs) are known as environmentally-friendly solvents that have emerged as an alternative to conventional organic solvents in recent years. In this study, the effects of ten different DESs on the extraction of bioactive components from the Hypericum perforatum were investigated. Total phenolic content, total flavonoid content, phenolic profile (32 phenolics), organic acid profile (52 organic acids), as well as antioxidant and antimicrobial activities of H. perforatum extracts prepared using DESs and ultrasonic-assisted extraction method were determined. Total phenolic, total flavonoid content, and antioxidant activities of extracts were determined between 3.10 ± 0.86–16.64 ± 2.09 mg GA/g, 0.02 ± 0.00–12.29 ± 0.30 mg QE/g, and 8.40 ± 0.50–44.78 ± 2.66 mg TE/g, respectively. DES2 (choline chloride:ethylene glycol) and DES7 (choline chloride:lactic acid) demonstrated higher extraction success than other DESs for extracting phenolics and organic acids, respectively. DESs prepared using organic acid as hydrogen bond donor were found to have an antibacterial effect against all bacterial samples. However, the inhibitory effect against yeast-like fungi was observed in a narrower spectrum. Moreover, the results from principal component analysis also confirmed that the type of solvent used for extraction has a significant influence on the phenolics, organic acid, and other parameters. As a result, it was seen that DES components directly affect the extraction efficiency of target compounds from H. perforatum. This is a first and original report about use of DESs in extracting different bioactive components from H. perforatum.
AtıfScopus33WoS31OpenAlex32İncele - MakaleAçık Erişim2023Scopus SJRQ3A Study on YouTube Channels of Foreign Languages Teaching Foundation
Maden, Sedat; Kaya, Musa
This study was conducted to examine the YouTube channels of Yunus Emre Institute, British Council, Institut Français, Instituto Cervantes, Confucius Institute and Goethe Institut foundations having channels on YouTube, one of the largest video sharing platforms of the world. The channels in this study, were examined through the qualitative research method in terms of the upload date, the numbers of subscribers, the numbers of videos, the videos’ grouping status, the number of video views, and the features of the most watched videos. As a result of the study, it appears that Yunus Emre Institute created its YouTube channel in 2014, British Council in 2010, Institut Français in 2017, Instituto Cervantes in 2017, Confucius Institute (U.S.) in 2017 and Goethe Institute in 2007. Yunus Emre Institute, one of the channels on YouTube, has more than 64400 subscribers, British Council has 542000, Institut Français has 3650, Instituto Cervantes has 69100, Confucius Institute has 801, and Goethe Institute has 301000. It is found that Yunus Emre Institute has 925, British Council has 134, Institut Français has 463, Instituto Cervantes has 1115, Confucius Institute has 82, and Goethe Institute has 1152 videos on YouTube. It has been determined that YouTube channels belonging to institutions established to teach the world's most spoken languages were created adopting similar paradigms and after the year 2007.
AtıfScopus1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ3Fear of missing out mediated the relationship between social appearance anxiety and phubbing in Turkish adults
Batmaz, Hasan; Çelik, Eyüp; Koçak, Lokman; Nur Tufan, Beyza; Makas, Samet; Yıldırım, Murat
The existing body of research lacks investigations into the potential links between fear of missing out (FOMO), social appearance anxiety, and phubbing. For the first time, this study examined the mediating role of FOMO in the relationship between phubbing and social appearance anxiety. Participants included 341 Turkish adults (Mage = 28.25, SD = 8.02) and completed the measures of FOMO, social appearance anxiety, and phubbing. Results showed that social appearance anxiety was positively related to FOMO and phubbing. Also, FOMO was positively associated with phubbing. The results of the mediation analysis indicated that FOMO partially mediated the association of social appearance anxiety with phubbing. These results suggest that social appearance anxiety exacerbates the FOMO, which in turn leads to an increased level of phubbing. These findings have significant implications for both research and practice.
AtıfScopus8OpenAlex5İncele - MakaleAçık Erişim2025Scopus SJRQ3The Comparison of Pre-Service Science Teachers' Drawings of the “Universe” Concept and the Universe Visuals They Created from Artificial Intelligence
Bostan Sarioğlan, Ayberk; Gürbüz, Fatih; Yakupoğlu, Melike
As the use of artificial intelligence increases in areas where people are active in our daily lives such as education and health, the comparison of human and artificial intelligence has started to be discussed. Many artificial intelligence programmes are commanded by humans and artificial intelligence creates products in line with expectations. In this study, it is aimed to compare the drawings of pre-service science teachers about the concept of universe with the universe visuals created by artificial intelligence. Case study was selected as the research model. The study group consisted of 24 pre-service science teachers studying in the 2nd and 4th grades of science teaching. The worksheet prepared by the researchers and the received expert opinion was used as a data collection tool. During the application process, pre-service teachers made drawings related to the concept of universe and described these drawings during two lesson hours. Then, they made drawings related to the concept of universe of artificial intelligence with the descriptions they entered into Microsoft Bing Search application. As a result, it was determined that pre-service teachers had different views in their drawings about the concept of universe. It is seen that the drawings of the pre-service teachers about the concept of universe and the visuals created by artificial intelligence are mostly like each other. In half of the drawings, the universe drawings of the pre-service teachers were more comprehensive, while in half of the drawings, artificial intelligence made more comprehensive drawings. Based on this result, it can be said that human perception and artificial intelligence products are in parallel with each other. Various suggestions were presented in line with the results of the study.
- MakaleAçık Erişim2024Scopus SJRQ2Niobium modification on dielectric, magnetic and structural features of nanocrystalline Ni–Co ferrites
Teber, Ahmet; Sarac, Mehmet Fahri
In this study, we will investigate the structural, characteristic, dielectric and magnetic features of Co0.5Ni0.5Nb xFe2–xO4 (0.0 ≤ x (with 0.2 increments) ≤ 1.0) nanoparticles, which are prepared via the hydrothermal approach. M-type hexagonal crystal structures are confirmed through XRD, FT-IR, SEM-EDS, TEM-SAED and VSM. Also, we have reported the investigations on dielectric properties and ac conductivity. Based on XRD measurements, it is concluded that all samples have M-type hexagonal crystal structure with nanocrystals ranging from 60 to 97 nm. The diffraction patterns obtained matched well with the calculated patterns from Rietveld analysis. Moreover, from the morphological analysis, it was observed that the small spherical structures of Ni–Co ferrite particles transformed into quadrilateral structures with increasing Nb concentration. The results of the FT-IR study show that the hexaferrite structure is formed as predicted because the expected range of absorption bands is present. According to VSM, Nb-substituted Ni–Co ferrite nanostructures reveal a relatively soft ferromagnetic property. Increasing the concentration of Nb tends to increase the coercive field (H c) variation. The dielectric factors and ac conductivity were measured in the frequency range of 0.1–10 MHz. The reduction in dielectric factors and tangent losses at low frequencies can be elucidated by both deformation and relaxation polarization mechanisms. Another observation is that ac conductivity is amplified with the applied frequency. In this sense, the electron and hole hopping phenomenon can explain the conduction mechanism.
- MakaleYalnız künye2022Scopus SJRQ1High-speed treatment of low strength domestic wastewater for irrigation water production in pilot-scale classical, moving bed and fixed bed hybrid MBRs
Tuluk, Banu; Yildiz, Ergun; Nuhoglu, Alper; Tataroglu, Numan Suadi; Gulluce, Ekrem; Cengiz, Ibrahim; Degermenci, Nejdet; Angin, Ilker
To evaluate the treatability of domestic wastewater under conditions of low hydraulic retention time and high organic loadings, 3 pilot-scale automatically controlled membrane bioreactors (MBRs) as classical (C-MBR), moving bed (MB-MBR), and fixed bed (FB-MBR) were established and operated for a total of 268 days. Established pilot plants were compared in terms of treatment performance, membrane fouling, irrigation water criteria, and power consumption values. Results obtained have shown that all three systems were able to achieve more than 93% removal of chemical oxygen demand (COD) in an average hydraulic retention time (HRT) of 1 hour, and MB-MBR and FB-MBR were superior in terms of total nitrogen (TN) and total phosphorus (TP) removals. It has been determined that MB-MBR and FB-MBR are also advantageous in terms of power consumption. Especially it has been found that FB-MBR can produce better quality irrigation water with 40% lower power consumption than C-MBR under the same conditions. It was concluded that biofilm-supported hybrid systems could be a practical application in the fight against increasing water scarcity and global warming, both in obtaining clean water with less power consumption and in protecting human and environmental health.
AtıfScopus16WoS11OpenAlex17İncele - MakaleAçık Erişim2022Scopus SJRQ1Recovery of Polyphenols Using Pressurized Hot Water Extraction (PHWE) from Black Rosehip Followed by Encapsulation for Increased Bioaccessibility and Antioxidant Activity
Kasapoğlu, Kadriye Nur; Demircan, Evren; Gültekin-Özgüven, Mine; Kruger, Johanita; Frank, Jan; Arslaner, Ayla; Özçelik, Beraat
In this work, pressurized hot water extraction (PHWE) of hydrophilic polyphenols from black rosehip fruit was maximized using response surface methodology for simultaneous optimization in terms of extraction yield, total antioxidant capacity, total (poly)phenols, catechin, total monomeric anthocyanins, and cyanidin-3-O-glucoside. Extraction parameters, including temperature (X1: 40–80 °C) and the solvent-to-solid ratio (X2: 10–40 mL/g), were investigated as independent variables. Experimentally obtained values were fitted to a second-order polynomial model, and optimal conditions were determined using multiple regression analysis and analysis of variance. The black rosehip extract (BRE) obtained at optimized PHWE conditions was further encapsulated in biopolymer-coated liposomes and spray dried to enhance its processing and digestive stability. After reconstitution, the fabricated particles had an average size of 247–380 nm and a zeta-potential of 15–45 mV. Moreover, encapsulation provided remarkable protection of the phenolics under in vitro gastrointestinal digestion conditions, resulting in up to a 5.6-fold more phenolics in the bioaccessible fraction, which also had 2.9–8.6-fold higher antioxidant activity compared to the nonencapsulated BRE. In conclusion, PHWE in combination with a biopolymer coating is a potent method for the production of stable and safe edible natural extracts for the delivery of (poly)phenolic compounds in food and dietary supplements.
AtıfScopus20WoS19OpenAlex20İncele - MakaleAçık Erişim2023Scopus SJRQ1Sustainability Ranking of Turkish Universities with Different Weighting Approaches and the TOPSIS Method
Akyol Özcan, Kübra
The concept of sustainability has become more important, especially as a result of the depletion of energy resources and increasing environmental concerns. UI GreenMetric ranks universities based on sustainability, environmental, and energy concerns, addressing issues of environmental pollution, food and water scarcity, and energy supply. By prioritizing sustainability on their campuses and campuses, universities are working to ensure a more sustainable future for humanity. This study evaluates university sustainability in energy and climate change using the UI GreenMetric ranking, focusing on Turkish universities’ sustainability ranking. It incorporates variables like infrastructure, energy, climate change, waste, water, public transportation, and educational research, using weighting approaches to reveal the most important variables for the country’s universities. The study utilized weighting techniques like CRITIC, entropy, standard deviation-based, and equal weighting approaches to obtain rankings for UI GreenMetric rankings. Entropy and equal weighting methods were found to be closest to the UI GreenMetric rankings. Universities’ rankings were analyzed using the TOPSIS method and four weighting techniques for 83 Turkish universities. For Turkish universities, the CRITIC method yielded the highest weight for energy and climate change variables, while water was identified as the most significant factor for entropy, installation infrastructure, and standard deviation-based weighting techniques.
AtıfScopus13WoS11OpenAlex15İncele - MakaleAçık Erişim2023Scopus SJRQ3Preventive and therapeutic effects of the peel powder of P. granatum in a rat sepsis model; [Preventivni i terapijski učinci praha kore pitomog šipka (P. Granatum) na modelu sepse u štakora]
Ülker, Ufuk; Demirel, Mürşide Ayşe; Bayraktar, Bülent; Alçıgır, Mehmet Eray; Aksoy, Adil
The aim of the present study was to evaluate the treatment potential of Punica granatum L. peel powder in an experimentally induced sepsis model in rats. Sepsis was induced in 10-week-old, male, Wistar Albino (n=24) rats. The animals were divided into four groups: Sham-operated (S) Group, Control (C) Group, Treatment-1 (T1) Group, and Treatment-2 (T2) Group. To induce the sepsis model, the cecal ligation and puncture procedure was performed. The P. granatum peel powder (200 mg/kg; per os) was applied one hour before (T1) and 10 hours after (T2) surgery in a volume of 2 mL. At the end of the experimental procedure, microbial and histopathological analyses were performed. The histopathological scores on the liver, lungs, heart, kidney, spleen, and pancreas were evaluated. Escherichia coli, Staphylococcus aureus and E. coli + S. aureus were isolated from blood cultures. Severe bacteria were detected in the blood of the group C animals. It was found that there were fewer bacteria in groups T1 (n=2) and T2 (n=4) compared with group C. There were no lesions in the pancreas tissues of any groups. Vascular changes, degeneration, and necrosis were common in the organs in all cases of group C compared to group S. The findings in group T1 were similar to those in group C, however, it was seen in fewer animals. It was determined that there was a general improvement in group T2, and in addition the existing lesions were moderate in severity. In conclusion, P. granatum L. peel powder prevented CLP-induced lung injury in experimental rats. Thus, P. granatum L. peel powder may be an alternative therapeutic agent against lung tissue injury induced by sepsis. The recovery from inflammation was better in group T2 than in the other groups. According to the results of the current study, P. granatum peel powder was found to be effective in the treatment of sepsis with antimicrobial and anti-inflammatory functions.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2023Scopus SJRQ3Synthesis of Arylsulfonyl Hydrazone Derivatives: Antioxidant Activity, Acetylcholinesterase Inhibition Properties, and Molecular Docking Study
Demirci, Yasin; Kalay, Erbay; Kara, Yakup; Güler, Halil İbrahim; Can, Zehra; Şahin, Engin
In this current paper, fifteen novel sulfonyl hydrazone derivatives have been successfully synthesized and evaluated for antioxidant activity as well as their effects on inhibitory activity toward acetylcholinesterase (AChE). By using 1H NMR, 13C NMR, FT-IR, and high-resolution mass spectrometry methods, the full characterization data of the novel compounds were obtained. The synthesized compounds capacity to inhibition glucosidase and exhibit antioxidant activity were tested in vitro. It was determined that compounds (E)-4-((2-((4-chlorophenyl)sulfonyl)hydrazone)methyl)-2-methoxyphenylfuran-2-carboxylate (21), (E)-2-methoxy-4-((2-(phenylsulfonyl)hydrazone)methyl)phenylfuran-2-carboxylate (17) and (E)-4-((2-((4-bromophenyl)sulfonyl)hydrazone)methyl)-2-methoxyphenylfuran-2-carboxylate (25) showed good antioxidant activity. Upon examining the acetylcholinesterase inhibitory activity, it was determined that compounds (E)-2-methoxy-4-((2-((4-methoxyphenyl)sulfonyl) hydrazone)methyl)phenylacetate (27) (10.39 μM), (E)-4-((2-((4-chloro phenyl)sulfonyl) hydrazone)methyl)-2-methoxyphenylfuran-2-carboxylate (21) (10.81 μM), (E)-4-((2-((4-chloro phenyl)sulfonyl)hydrazone)methyl)-2-methoxyphenyl thiophene-2-carboxylate (22) (12.92 μM) and (E)-2-methoxy-4-((2-(phenylsulfonyl)hydrazone)methyl)phenylfuran-2-carboxylate (17) (12.93 μM) showed potent inhibitory effects. Molecular docking simulations were used to investigate the interactions of novel sulfonyl hydrazone derivatives with human acetylcholinesterase protein. The ligands exhibited strong binding to the receptor protein with potent inhibition.
AtıfScopus18WoS18OpenAlex19İncele - MakaleYalnız künye2022Scopus SJRQ3The Importance of Nutrition and a Balanced Diet in the Elderly during the COVID-19 Pandemic
Esgin, Özge; Erten, Tayyibe
Background: Age is an important risk factor for the mortality rate in the COVID-19 disease, and mostly, hospitalised patients over 60 years with chronic diseases are at high risk of death due to this disease. Along with preventive measures, proper nutrient intake might be helpful in maintaining a healthy state or reduce the severity of the COVID-19 disease in the elderly. Methods: The search was carried out in the PubMed, Scopus, Medline, Google Scholar and Web of Science using the following terms: COVID-19, coronavirus, elderly, elderly nutrition. Results: The requirement for some macro and micronutrients, especially the nutrients that support the immune activity, increases in this disease. During the pandemic, the daily energy requirement for the elderly is 27-30 kcal/kg, while the protein intake is at least 1g/kg, and the ratio of fat and carbohydrate is 30:70 or less than 50:50. The daily intake of vitamin A, B6, B12, C, D, zinc and selenium can also be increased due to their supporting function in the immune system. Probiotics include Bifidobacterium longum MM-2, Lactobacillus plantarum 06CC2, Lactobacillus bulgaricus OLL1073R-1 and Lactobacillus rhamnosus M21, and the consumption of prebiotics in diet enhances the immune function. Additionally, flavonoids, such as baicalin, epigallocatechin gallate, gallocatechin gallate, kaempferol, luteolin, resveratrol and quercetin, improve immunity by reducing oxidative stress in the elderly. Conclusion: Adequate and balanced nutrition diet should be applied during the pandemic; in addition to this, micronutrient deficiencies should also be overcome in the elderly at every stage of life. Nuron&The novel coronavirus, called SARS-CoV2 (Severe Acute Respiratory Syndrome CoronaVirus-2), emerged at the end of 2019 in China and was announced as a global pandemic by the World Health Organisation (WHO) on March 11th, 2020 [1]. It has spread more rapidly than previous coronavirus outbreaks, such as SARS-CoV and MERS-CoV (Middle East respiratory syndrome coronavirus); thus, it has affected most countries [2, 3]. By August 2021, WHO reported globally 206.958.371 confirmed cases of COVID-19, including 4.357.179 deaths [4]. Since SARS-CoV-2 enters the cells through angiotensin-converting enzyme 2 (ACE2), it binds to the ACE2 membrane of alveolar epithelial cells and attacks firstly the respiratory system [5].
AtıfScopus1WoS1OpenAlex1İncele - MakaleYayıncıda açık erişim2024Scopus SJRQ1Multi-method examination of contact mechanics in orthotropic layers under gravity
Öner, Erdal; Uzun Yaylacı, Ecren; Yaylacı, Murat
Analyzing the behavior of intelligent unconventional materials under diverse contact scenarios, in comparison to conventional materials, is a critical step in the initial design of engineering systems. This paper presents the development of analytical and numerical approaches for analyzing contact mechanics in a system comprising an orthotropic layer resting on a rigid foundation. Parametric analyses include the consideration of cylindrical and flat punch profiles. Analytical formulation utilizes integral transform methods to convert planar elasticity equations into a Cauchy-type singular integral equation of the second kind. A detailed description of the solution technique for the integral equation is provided, encompassing both the analytical formulation and the required discretization for obtaining the solution. Subsequently, a finite element approach (FEA) is employed to approximate contact bodies using a collection of finite elements, while contact boundaries are approximated by utilizing a set of polygons. Alternatively, the problem is addressed using the Multilayer Perceptron approach, a form of artificial neural network frequently applied in diverse machine learning applications, including scenarios involving contact problems. Finally, the resolution to the problem is achieved by employing the multilayer perceptron (MLP) method. The study yields determinations of contact stresses under the punch, the critical separation load resulting in the detachment of the orthotropic layer from the rigid foundation, and the corresponding separation distance. This analysis considers a range of dimensionless parameters and explored the behavior of diverse orthotropic materials. Comparisons between the results of the analytical method and computations from FEA and MLP reveal the exceptional accuracy attained by all three approaches. As the pioneer study employing three distinct approaches to examine continuous contact mechanics within an orthotropic layer under the influence of gravity, this research constitutes a valuable point of reference for upcoming scholars in the field.
AtıfScopus50WoS53OpenAlex44İncele - MakaleAçık Erişim2024Scopus SJRQ3Change in Wood Color Due To The Use of Waste Vegetable Oils
Ayata, Ümit
An investigation was carried out without the use of thermal treatment to determine whether waste oils have color-altering effects on wood material surfaces. Waste vegetable oils (walnut, sunflower, corn, and olive) were applied to the surfaces of wood materials from ayous (Triplochiton scleroxylon K. Schum), fukadi (Terminalia amazonia), guatambú (Balfourodendron riedelianum (Engl.) Engl.), mahogany (Swietenia mahagoni (L.) Jacq.), and rengas (Gluta renghas L.) tree species. Subsequently, a control group was established, and experimental samples were compared. Changes in color parameters (L*, ∆a*, C*, ∆L*, a*, ∆b*, ho, ∆H*, b*, ∆C*, and ∆E*) were investigated. The results of multivariate analysis of variance for color parameters (C*, ho, L*, a*, and b*) were found to be statistically significant. A decrease in ho and L* was observed for all wood types and waste oils. On the other hand, a* and b* values increased and C* values decreased in guatambú and ayous wood on application of all waste vegetable oils. However, in the case of mahogany and rengas wood, a* and b* values decreased while C* values increased.
AtıfScopus1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ1De-Embedding Technique for Parameter Extraction of Biaxial Bianisotropic Metamaterial Slabs
Hasar, Ugur Cem; Kaya, Yunus; Korkmaz, Huseyin; Iliev, Teodor
Among material classes of isotropic, anisotropic, bi-isotropic, and bianisotropic, the latter class is important because, as different from other classes, the bianisotropic class can describe complex behavior of various materials through tensor expressions between electric and magnetic fields via electric and magnetic flux densities. All electromagnetic parameters (a total of seven) of a general bianisotropic material need to be accurately extracted for understanding its response and characteristic. Extraction methods can be utilized for such a goal. However, the extraction methods in the literature either require a formal calibration procedure or are limited to the extraction of three electromagnetic parameters only. In this study, an attractive self-calibrating waveguide method has been devised for determination of electromagnetic parameters of biaxial biansiotropic metamaterial (MM) slabs. Its first advantage is that it uses a thru connection in addition to the MM-loaded line connection (three different configurations - Case A, Case B, and Case C) and empty-line connection next to the MM-loaded line connection to extract all (seven) constitutive parameters together with the magnetoelectric coupling coefficient. Its second advantage is that it relies on explicit expressions and does not require any calibration process for such an extraction. Simulations and uncalibrated scattering parameter waveguide measurements at X-band (8.2 - 12.4GHz) were performed for a biaxial bianisotropic MM slab made by C-patterned resonators to validate the proposed method. It is observed that extracted electromagnetic parameters by the proposed method satisfy the passivity conditions over the entire frequency band except for a few frequency points or regions (e.g., f = 8.2 GHz). Its reason is expected to be associated with the difficulty in satisfying the continuous medium property at such frequencies. Besides, it is noted that two of the constitutive parameters (ɛ 2 and μ3) illustrate a thickness-resonance behavior revealed by additional measurements of the Case B - MM structure with different lengths (7.675 mm, 9.21 mm, and 10.475 mm). Besides, it is noted that the resonance behavior of the Case C - MM structure changes with a change in periodicity. Specifically, when the periodicity in the x direction of this MM structure changes from approximately 3.26 mm to 2.29 mm, the resonance frequency shifts from nearly 10.43 GHz to 10.30 GHz (a 1.25% variation). Finally, sensitivity, uncertainty, and error analyses were also performed to evaluate and improve its accuracy. It is observed that |3/Λ 1A| | is 14 times greater than | xi 0 / Λ 1A| | at 10.85 GHz where Λ 1A is one of the terms related to measured S-parameters for the Case A - MM structure, and |∗ | denotes the magnitude of the complex number ∗
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