Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Kutlu, Naciye(5)
- Ecem Bayram, Nesrin(4)
- Gerçek, Yusuf Can(4)
- Bayram, Sinan(3)
- Çelik, Saffet(3)
- Akeren, Zahide(2)
- Baştürk, Fatma Nur(2)
- Bulbuloglu, Semra(2)
- Kalyoncuo, Servet(2)
- Kamiloğlu, Aybike(2)
- Kırkıncı, Seran(2)
- Akeren, Ihsan(1)
- Altuntas, Serkan(1)
- Alış, Halil(1)
- Argün, Ziya(1)
- Arici, M.(1)
- Artar, Pınar Tuğçe(1)
- Ataoğlu, Nigar Esra Erkoç(1)
- Aydemir, Serdar(1)
- BAL, Betül(1)
- Bayraktar, B.(1)
- Büyükaşık, Süleyman(1)
- Can, Özgür Devrim(1)
- Cevahir Öz, Gül(1)
- Civelek, Mustafa(1)
- Daştan, Buket(1)
- Demir Özkay, Ümide(1)
- Demir, Bilsev(1)
- Demirkesen, Özlem Cemile(1)
- Dereli, Turkay(1)
- Dertli, E.(1)
- Dirican, E.(1)
- Dirican, Ebubekir(1)
- Elbir Abca, Tuğba(1)
- Esgin, Özge(1)
- Gunes, Huseyin(1)
- Gunes, Hüseyin(1)
- Gül, M.(1)
- Gülbahar, Özlem(1)
- Güneş, Hüseyin(1)
Yayınlar
- MakaleAçık Erişim2020Scopus SJRQ1Antiamnesic effects of tofisopam against scopolamine-induced cognitive impairments in rats
Üçel, Umut İrfan; Can, Özgür Devrim; Demir Özkay, Ümide; Ulupinar, Emel
In this study, we investigated the potential therapeutic effects of tofisopam, a 2,3-benzodiazepine derivative anxiolytic, on cognitive deficits in rats with scopolamine-induced amnesia. Cognitive performance of the rats was investigated by using the Morris water maze and passive avoidance tests. Changes in motor activity were assessed by using the activity cage and Rota-rod tests and then morphological changes in the hippocampus were assessed via immunohistochemical stainings. The results indicated that scopolamine impaired learning and memory parameters in rats. Worsened cognitive performance, neuronal loss, and decreased hippocampal synaptophysin, Ki-67, and glial fibrillary acidic protein density were observed. Tofisopam administration at a dose of 50 mg/kg for seven days improved the impaired cognitive performance, enhanced the attenuated synaptic transmission in the hippocampus, increased proliferation in subgranular zones, and improved the decrease in astrocytes in amnesic rats. These findings point out the anti-amnesic effects of tofisopam with concomitant improvements in the hippocampal synaptogenesis, neurogenesis, and glial plasticity, for the first time. Presented beneficial effects of tofisopam on cognitive dysfunctions may have a notable clinical value considering the fact that one of the most important side effects of 1,4-benzodiazepines, which are classical anxiolytic drugs, is amnesia. However, these preclinical results need to be confirmed with further clinical studies, first.
AtıfScopus23WoS20OpenAlex22
İncele - MakaleAçık Erişim2016Scopus SJRQ1Effects of milk somatic cell counts on some physicochemical and functional characteristics of skim and whole milk powders
Sert, Durmuş; Mercan, Emin; Aydemir, Serdar; Civelek, Mustafa
The aim of this work was to study the influence of milk somatic cell count (SCC) levels on spray-dried milk powders. For this reason, 3 cow milks with different SCC (<300,000, 300,000-700,000, >700,000 SCC/mL) were processed into skim (SMP) and whole milk powder (WMP). The effect of SCC on the physicochemical and functional characteristics of the milk powders and textural properties of set-type yogurts produced from reconstituted milk powders with different SCC was evaluated. A crucial difference was noted between milk powders depending on different SCC. Protein values and ash content of powder samples decreased correlatively with increasing SCC. The hydroxymethylfurfural content of SMP was higher than WMP. We noted an increase in hydroxymethylfurfural content of both SMP and WMP depending on elevated SCC. Solubility index of SMP and WMP was 1.280 to 1.632 and 0.940 to 1.208 mL, respectively; with increasing SCC, solubility index was affected adversely. The highest foam stability was determined in SMP containing >700,000 SCC. Bulk density of SMP and WMP was between 0.682 and 0.708 and 0.660 to 0.685 g/cm3, respectively. An increase was observed in scorched particle of both SMP and WMP depending on increasing SCC. We found significant differences in particle size distribution of milk powders produced from milk with SCC at different levels. Although WMP had more uniform and big particle structure, SMP had more specific area. A negative correlation was noted between yogurt texture and SCC. Results indicate that milk SCC has negative influences on milk powder quality.
AtıfScopus24WoS18OpenAlex27İncele - MakaleAçık Erişim2015Scopus SJRQ1Effect of in situ exopolysaccharide production on physicochemical, rheological, sensory, and microstructural properties of the yogurt drink ayran: An optimization study based on fermentation kinetics
Yilmaz, M.T.; Dertli, E.; Toker, O.S.; Tatlisu, N.B.; Sagdic, O.; Arici, M.
Exopolysaccharide (EPS)-producing starter cultures are preferred for the manufacture of fermented milk products to improve rheological and technological properties. However, no clear correlation exists between EPS production and the rheological and technological properties of fermented milk products such as the yogurt drink ayran. In this study, 4 different strain conditions (EPS- and EPS+ Streptococcus thermophilus strains) were tested as a function of incubation temperature (32, 37, or 42°C) and time (2, 3, or 4 h) to determine the effect of culture type and in situ EPS production on physicochemical, rheological, sensory, and microstructural properties of ayran. Furthermore, we assessed the effect of fermentation conditions on amounts of EPS production by different EPS-producing strains during ayran production. A multifactorial design of response surface methodology was used to model linear, interaction, and quadratic effects of these variables on steady shear rheological properties of ayran samples and in situ EPS production levels. The physicochemical and microbiological characteristics of ayran samples altered depending on incubation conditions and strain selection. Steady shear tests showed that ayran samples inoculated with EPS+ strains exhibited pseudoplastic flow behavior. Production of ayran with EPS- strain (control sample) resulted in the lowest apparent viscosity values (η50), whereas those produced with the combination of 2 EPS+ strains yielded ayran with notably increased η50 values. We concluded that incubation time was the variable with the greatest effect on η50, consistency coefficient (K), and flow behavior index (n) values. In situ EPS production was also affected by these conditions during ayran fermentation in which strain-specific metabolism conditions were found to be the most important factor for EPS production. In addition, these findings correlated the amount of in situ EPS produced with the rheological properties of ayran. Scanning electron microscopy images of the samples showed differences in structural features, revealing a prominent network strand structure in the ayran samples inoculated with the admixture of 2 EPS-producing strains incubated at 37°C for 3 h. These results provide useful information for large-scale production of ayran by the dairy industry.
AtıfScopus79WoS65OpenAlex92İncele - MakaleAçık Erişim2015Scopus SJRQ1Analysis of patent documents with weighted association rules
Altuntas, Serkan; Dereli, Turkay; Kusiak, Andrew
Analysis of relationship among various technologies may result in technology maximizing profits. Weighted association rules are proposed to determine dependencies across technologies. The proposed approach recognizes uneven importance of patents and technology class in terms of their technological impact and commercial significance. The proposed analysis approach is illustrated with a case study.
AtıfScopus46WoS39OpenAlex49İncele - DergiTechnological Forecasting and Social Change
- DergiJournal of Dairy Science
- DergiJournal of Applied Poultry Research
- DergiGene Reports
- DergiPharmacology Biochemistry and Behavior
- DergiJournal of Mathematical Behavior
- DergiApplied Mathematical Modelling
- DergiExplore
- DergiContemporary Clinical Trials
- DergiMicrochemical Journal
- DergiGeriatric Nursing
- DergiClinical Simulation in Nursing