Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Kutlu, Naciye(5)
- Ecem Bayram, Nesrin(4)
- Gerçek, Yusuf Can(4)
- Bayram, Sinan(3)
- Çelik, Saffet(3)
- Akeren, Zahide(2)
- Baştürk, Fatma Nur(2)
- Bulbuloglu, Semra(2)
- Kalyoncuo, Servet(2)
- Kamiloğlu, Aybike(2)
- Kırkıncı, Seran(2)
- Akeren, Ihsan(1)
- Altuntas, Serkan(1)
- Alış, Halil(1)
- Argün, Ziya(1)
- Arici, M.(1)
- Artar, Pınar Tuğçe(1)
- Ataoğlu, Nigar Esra Erkoç(1)
- Aydemir, Serdar(1)
- BAL, Betül(1)
- Bayraktar, B.(1)
- Büyükaşık, Süleyman(1)
- Can, Özgür Devrim(1)
- Cevahir Öz, Gül(1)
- Civelek, Mustafa(1)
- Daştan, Buket(1)
- Demir Özkay, Ümide(1)
- Demir, Bilsev(1)
- Demirkesen, Özlem Cemile(1)
- Dereli, Turkay(1)
- Dertli, E.(1)
- Dirican, E.(1)
- Dirican, Ebubekir(1)
- Elbir Abca, Tuğba(1)
- Esgin, Özge(1)
- Gunes, Huseyin(1)
- Gunes, Hüseyin(1)
- Gül, M.(1)
- Gülbahar, Özlem(1)
- Güneş, Hüseyin(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ2Perceived burdensomeness and happiness in cohabiting older adults: The serial mediating roles of mental well-being and loneliness
Akeren, Zahide; Akeren, Ihsan; Kalyoncuo, Servet
Background Aging-related changes and increased dependence on family members may negatively affect older adults’ psychological well-being. Perceived burdensomeness refers to the belief that one is a burden on others and has been associated with lower happiness, reduced mental well-being, and greater loneliness. Among adults living with their families, mental well-being and loneliness may explain how perceived burdensomeness relates to happiness in later life. Purpose This study examined the associations between perceived burdensomeness and happiness among older adults living with their families and evaluated the serial mediating roles of mental well-being and loneliness. Methods This cross-sectional study included individuals aged ≥65 years residing with family members in a city in Turkey’s Eastern Black Sea region. Data were collected from 273 older adults; after preliminary screening, 7 cases were excluded, resulting in a final analytic sample of N = 266. Measures included the Geriatric Feelings of Burdensomeness Scale, WHO-5, the Happiness Scale, and the Loneliness Scale for the Elderly. Serial mediation was tested using a regression-based approach with bootstrap confidence intervals. Results Perceived burdensomeness was associated with lower mental well-being and higher loneliness. The total association between burdensomeness and happiness was negative (β=-0.467), and more than two-thirds of this association operated indirectly through mental well-being and loneliness. Conclusion and Implications Perceived burdensomeness was associated with lower happiness among older adults living with their families, primarily through reduced mental well-being and increased loneliness. In geriatric nursing and primary care, routinely assessing these psychosocial factors and implementing family-centered and social support-oriented interventions may help improve happiness.
AtıfScopus1OpenAlex1
İncele - MakaleAçık Erişim2026Scopus SJRQ1A comprehensive parametric study of contact behavior in functionally graded bilayer systems
Öner, Erdal; Artar, Pınar Tuğçe
An extensive body of research in contact mechanics has been conducted due to its broad relevance to numerous engineering systems of practical interest. The investigation of contact behavior in deformable bodies represents a major challenge in engineering, as it plays a crucial role in the performance of structural and mechanical systems. Due to its importance, the field has received considerable attention in the literature. The present study focuses on analyzing the contact problem of a two-layered system composed of a functionally graded orthotropic layer (FGOL) and a functionally graded isotropic layer (FGIL). The layered system is fully bonded to a rigid substrate (RS), and frictional effects are neglected. No bonding is assumed between the two layers. The system is subjected to loading through a flat-ended rigid indenter (FERI), and the body forces of both layers are incorporated into the formulation. In the solution of the contact problem, the condition of constant vertical displacement (and thus its zero derivative) under the FERI is defined as the boundary condition; it is subsequently reduced to a singular integral equation through the application of Fourier integral transform techniques. This integral equation is subsequently solved numerically by applying the Gauss–Chebyshev integration formula. A comprehensive parametric study is conducted with respect to different material configurations and various dimensionless parameters, providing detailed insight into the mechanical response of the functionally graded layered system.
- MakaleYalnız künye2025Scopus SJRQ2Optimized ultrasonic-NaDES extraction of anthocyanins, polyphenolics, and organic acids from chokeberry fruit with blueness and antimicrobial evaluation
Gerçek, Yusuf Can; Kutlu, Naciye; Çelik, Saffet; Bayram, Sinan; Kırkıncı, Seran; Ecem Bayram, Nesrin
Deep eutectic solvents (DESs) have been widely used in food processing in recent years, owing to their remarkable advantages. The aim of this study was to evaluate the potential of DESs for the recovery of bioactive components from chokeberry fruit. First, among the 10 different DESs, the DES that extracted the highest total individual phenolic content (TIPC) from chokeberry was determined. Then, ultrasonically assisted extraction conditions (ultrasonic amplitude, time, and temperature) were optimized by response surface methodology to obtain the maximum amount of TIPC using this DES. According to the results obtained, the natural deep eutectic solvent (NaDES) choline chloride: acetic acid (1:2, 30% water content) provided the highest yield for TIPC extraction and the optimum conditions for maximum TIPC extraction were determined as 100% for ultrasonic amplitude, 50 °C for temperature and 60 min for sonication time. The TIPC content of the extracts prepared with this NaDES was determined between 1740.26 and 3703.14 mg/kg. In addition, the individual organic acid and individual anthocyanin contents of the NaDES extracts, as well as their antioxidant and antimicrobial activities, were determined. Chlorogenic acid (1392.351–2361.48 mg/kg) among phenolic compounds, pyruvic acid (9361.35–47398.04 mg/kg) among organic acids and kuromanin chloride (69748.13–134668.24 mg/kg) among anthocyanins were the dominant compounds in NaDES extracts. However, the extracts showed varying levels of antimicrobial activity against Gram (+) bacteria, Gram (−) bacteria, and yeast-like fungi (Candida strains). Finally, the Blue Applicability Grade Index (BAGI) was used to evaluate the practicality/blueness potential of the chromatographic method used to determine the anthocyanin composition of the DES extracts. In conclusion, NaDES (choline chloride:acetic acid) can be an alternative solvent for the recovery of some individual phenolics, organic acids and anthocyanins under different extraction conditions. In addition, the use of NaDES in the recovery of various functional compounds needed in food, cosmetics, pharmaceuticals, etc., is important for the promotion of sustainability and green technology.
AtıfScopus19WoS18OpenAlex19İncele - MakaleAçık Erişim2025Scopus SJRQ1The effect of laughter yoga on disease acceptance, treatment adherence and comfort in hemodialysis patients: A randomized controlled study
BAL, Betül; KÖROĞLU-KABA, Nagihan; ÖZTÜRK, Havva; KURT, Yeter; ÖZSABAN, Aysel
The aim of this study was to determine the effect of laughter yoga on hemodialysis patients' disease acceptance, treatment adherence and comfort levels. This randomized controlled study was conducted with 42 patients (experimental group=21, control group=21) who were treated in the hemodialysis unit. Hemodialysis patients in the experimental group received 12 sessions of laughter yoga for four weeks, three days a week. Data were collected using Patient Information Form, Disease Acceptance Scale, End-Stage Renal Disease Adherence Questionnaire, and Hemodialysis Comfort Scale. A significant difference was found between the disease acceptance scale (t(41) = 4.39, p < 0.001, d = 1.364), end-stage renal failure adaptation scale (t(41) = 2.69, p = 0.010, d = 0.830) and hemodialysis comfort scale (t(41) = 5.58, p = 0.010, d = 1.710) of hemodialysis patients who underwent laughter yoga. In addition for the Disease Acceptance Scale, the SD of the pre-test scores was 7.51. Accordingly, the MCID thresholds were calculated as 3.75 (0.5 SD), 3.11 (1 SEM), and 6.09 (1.96 SEM). For the End-Stage Renal Disease Adherence Questionnaire, the SD was 178.79, and the MCID was calculated as 89.40 (0.5 SD), 63.47 (1 SEM), and 124.39 (1.96 SEM). For the Hemodialysis Comfort Scale, the SD was 6.43, resulting in MCID estimates of 3.21 (0.5 SD), 2.01 (1 SEM), and 3.94 (1.96 SEM). Laughter yoga practiced during hemodialysis increased acceptance of the disease, adherence to treatment, and comfort (p < 0.05). In contrast, no statistically significant difference was found in the control group (p > 0.05). Increasing hemodialysis patients' acceptance of the disease, adherence to treatment, and comfort levels ensure the successful continuation of the disease management process. The practice of laughter yoga in clinics during hemodialysis sessions is recommended to increase disease acceptance, adherence to treatment and comfort levels.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ1The effect of dietary education on attitudes and behaviors in hemodialysis patients: A randomized trial
Akeren, Zahide; Çakmak, Vahide Semerci; Kalyoncuo, Servet
Background: Hemodialysis patients are at high risk for poor dietary status, primarily due to limited adherence to complex dietary regimens. Inadequate adherence may lead to complications and negatively adversely affect treatment outcomes. Promoting positive dietary attitudes and behavioral change is essential to improve health in this population. Aim: This study aimed to evaluate the impact of a structured dietary education program on dietary attitudes, daily diet intake, and vital signs in hemodialysis patients. Methods: The study was conducted between December 15, 2023, and March 27, 2024, with 34 patients (17 experimental, 17 control) receiving treatment at a public hospital in northeastern Turkey. Data were collected using the Patient Information Form, 24-Hour Diet Recall, Attitude Scale for Dietary Therapy of Hemodialysis Patients (ASDTHP), and Vital Signs Form. The experimental group received structured dietary education in two weekly 40-min sessions. Analyses were performed using BeBIS 9.0 and SPSS 25. Results: The mean age of participants in the experimental group was 59.94 ± 11.80 years; 64.7 % were male, and 64.7 % were primary/middle school graduates. In the experimental group, significant improvements were found in the total ASDTHP score, including the cognition-influenced and diet culture-related behavioral subdimensions (p < 0.05). Additionally, post-intervention analysis showed showed statistically significant reductions in systolic blood pressure, and pulse rate and increase in potassium intake (p < 0.05). Conclusion: Dietary education improved dietary attitudes and positively influenced certain vital signs, including blood pressure, in hemodialysis patients. However, it did not lead to statistically significant changes in other macronutrient and micronutrient intake variables.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2Quantification of phenolics by LC-MS/MS of monofloral and polyfloral Honey: Evaluation of the greenness of the method with MoGAPI and MoGSA
Gerçek, Yusuf Can; Baştürk, Fatma Nur; Özkök, Aslı; Cevahir Öz, Gül; Ecem Bayram, Nesrin
This study evaluated the physicochemical properties, total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity, proanthocyanidin content, and polyphenolic profiles of monofloral and multifloral honey samples produced in Türkiye. In addition, the greenness of the analytical method was assessed using two different evaluation tools: MoGSA and MoGAPI. The TPC and TFC values for multifloral honeys ranged from 0.18–0.65 mg GAE/g and 0.01–0.09 mg QE/g, respectively, whereas for monofloral honeys, these values ranged from 0.16–0.98 mg GAE/g and 0.01–0.37 mg QE/g. The highest CUPRAC and DPPH values were observed in Erica spp. honey, consistent with its TFC and total individual polyphenolic compound results. Notably, the Erica spp. honey sample exhibited a significantly higher gallic acid content (26.13 µg/g) compared to the other samples. These findings suggest that Erica spp. honey characterized by its high TPC, antioxidant activity, and distinctive polyphenolic profile, may serve as a notable dietary source of antioxidants. Additionally, the MoGAPI and MoGSA scores of the method were determined to be 84 and 91.67, respectively, demonstrating its high environmental sustainability.
AtıfScopus4WoS4OpenAlex3İncele - MakaleYalnız künye2025Scopus SJRQ2Influence of ultrasonic-assisted deep eutectic solvent extraction on bioactive compounds from germinated mung beans (Vigna radiata) and greenness assessment
Yücel, Tuğçenur; Kamiloğlu, Aybike; Kutlu, Naciye
In this study, the ultrasonic-assisted method was applied to extract phenolic, flavonoid, and antioxidant compounds from germinated mung beans. In addition, deep eutectic solvents (DESs) were chosen as solvents to support the green concept and to increase their applicability. Choline chloride is a quaternary ammonium salt and was used as the hydrogen bond acceptor (HBA), and compounds from the alcohol, organic acid, sugar, and amide groups were combined as hydrogen bond donors (HBD) to obtain 8 different DESs. Higher yields were obtained with ultrasonic-assisted DESs compared to the traditional method (maceration) when total phenolic compound and antioxidant activities were evaluated. While the most effective solvent for total phenolic compound yield was choline chloride:fructose, the highest antioxidant activity values were obtained with solvents using organic acids as HBD. Moreover, Blue Applicability Grade Index (BAGI) was used to assess the greenness of the applied ultrasonic-assisted spectrophotometric extraction and DESs. As a result, using green technology and green solvents was influential in the extraction of bioactive compounds, and their applicability was especially effective for mung beans.
AtıfScopus8WoS7OpenAlex8İncele - MakaleAçık Erişim2025Scopus SJRQ2Mind diet adherence associated with lower Zonulin levels in older Parkinson's patients
Esgin, Özge; Tokçaer Bora, Hatice Ayşe; Gülbahar, Özlem; Demirkesen, Özlem Cemile; Ataoğlu, Nigar Esra Erkoç; Söke, Fatih; Özçelik, Ayşe Özfer
Aim: This study investigates the association between adherence to the MIND diet and serum zonulin levels in older adults with Parkinson's disease (PD). Methods: Data were collected through structured survey forms and blood samples. The survey assessed general information, 24-hour food recalls, anthropometric measurements, the MIND diet adherence and physical activity levels. Zonulin levels were analysed from blood samples. Results: The study included 57 older adults with PD in stages 1–3 on the Hoehn & Yahr scale (29 women, 28 men; mean age 70.2 ± 4.6 years). Zonulin levels were negatively correlated with dietary total antioxidant capacity (p < 0.05). In adjusted analyses, higher adherence to the MIND diet was associated with lower zonulin levels (β = −0.25). Conclusions: These findings suggest a novel link between adherence to the MIND diet and reduced zonulin levels. MIND diet could have potential benefits for neurological function and intestinal barrier integrity.
- MakaleYalnız künye2024Scopus SJRQ1The effect of sociodemographic characteristics and polypharmacy on loneliness and social isolation in community-dwelling older adults
Sönmez Sari, Ebru; Çetinkaya Özdemir, Serap; Semerci Çakmak, Vahide; Kurt, Fatma
The aim of this study was to assess the impact of sociodemographic factors and polypharmacy on loneliness and social isolation in older adults. This cross-sectional study included 370 older adults with and without polypharmacy. The data were gathered via the Personal Information Form, Loneliness Scale for Elderly, and Lubben Social Network Scale-Revised. A multivariate ANOVA (MANOVA) was conducted to assess the impact of independent variables on the combined dependent variables. Loneliness and social isolation were found higher in older adults with polypharmacy. In addition, loneliness and social isolation are more common in women, individuals with low educational attainment, single individuals, individuals with low income, individuals living in rural areas, individuals with poor family relationships, individuals not living with their families and individuals with chronic diseases. It is thought that the findings of this study will be guiding for all health professionals working in the field of elderly health in interventions to be planned for the elderly population.
AtıfScopus6WoS5OpenAlex5İncele - MakaleAçık Erişim2024Scopus SJRQ1Ultrasonic assisted extraction of water-soluble vitamins from minor components of bee pollen with deep eutectic solvents (DESs) as green solvent
Çelik, Saffet; Gerçek, Yusuf Can; Kutlu, Naciye; Bayram, Sinan; Kırkıncı, Seran; Ecem Bayram, Nesrin
In this study, different deep eutectic solvents (DESs) were used for vitamin extraction from bee pollen. The DES combination with the highest total amount of individual vitamins was choline chloride: ethylene glycol (molar ratio 1:2). The response surface method was then used to optimize the extraction conditions. The independent variables used for optimization were ultrasonic power, time, and temperature, while the dependent variables were the total individual amino acids, total individual phenolic compounds, and total individual vitamin contents. Spectrophotometric analyses and antimicrobial activity were also determined in the extracts. In addition, AGREEprep, ComplexGAPI and BAGI tools were used to evaluate the greenness of the method. The results obtained with DES were compared with water, ethanol, and methanol extracts, which were considered control groups. As a result of optimization, the optimum conditions were found to be 75 % for ultrasonic power, 71.5 min for sonication time, and 40 °C for ultrasonic bath temperature. The model's composite desirability value (d) was found to be 0.81. The predicted value and the experimental values were close to each other. Furthermore, the most dominant vitamin in DES extracts was ascorbic acid, the most dominant amino acid was proline, and the most dominant phenolic compound was myricetin. The amounts of these compounds were higher than those obtained from water, ethanol, and methanol extracts. The spectrophotometric analysis results obtained higher yields with DES compared to the control groups. Antimicrobial activity analysis showed that pollen extracts prepared using choline chloride: ethylene glycol had a weak inhibitory effect for Gram-positive and Gram-negative bacteria but not yeast-like fungal strains. In conclusion, DES has been successfully used to extract vitamins and other bioactive compounds from bee pollen. The results obtained showed that DESs can be an alternative to organic solvents for the extraction of vitamins, which are among the minor components of bee pollen. Besides, the potential of the application different DESs for more efficient extraction of vitamins and components with important pharmaceutical properties from bee pollen needs to be evaluated in detail.
AtıfScopus14WoS12OpenAlex14İncele - MakaleAçık Erişim2024Scopus SJRQ1The impact of surgical intervention on religious coping, psychological well-being, and pain levels in older adult patients: A quasi-experimental study
Daştan, Buket; Kulakaç, Nurşen
Aim: This study aimed to determine the impact of surgical intervention on religious coping, psychological well-being, and pain levels in older adult patients. Method: The data of the study, which used a one-group pretest-posttest quasi-experimental design without a control group, was collected between July 1, 2023, - January 30, 2024. Data collection involved the use of a Personal Information Form, the Religious Coping Scale, the Psychological Well-Being Scale, and the Visual Analog Scale. Results: The results revealed a significant increase in psychological well-being and positive religious coping after surgical intervention compared to presurgical levels (p < 0.001). Multiple linear regression analysis revealed that male gender, younger age, enhanced psychological well-being, and positive religious coping were identified as factors contributing to a reduction in postsurgical pain levels. Conclusion: The study's results indicate that surgical intervention serves as a significant variable influencing psychological well-being and religious coping among older adult patients.
AtıfScopus2WoS1OpenAlex2İncele - MakaleYalnız künye2024Scopus SJRQ1Ultrasound assisted choline chloride-based deep eutectic solvent extraction of bioactive compounds from salsify (Tragopogon buphthalmoides (DC.) boiss. Var. Latifolius Boiss.): A Box–Behnken design approach for optimization
Yilmaz, Özlem; Elbir Abca, Tuğba; Kamiloğlu, Aybike; Kutlu, Naciye
This study aimed to investigate the ultrasound-assisted extraction of bioactive compounds from salsify using deep eutectic solvents (DESs) with different molar ratios. For this reason, total phenolic (TPC), total flavonoid (TFC) compounds, and antioxidant activities (1,1-diphenyl-2-picrilhydrazyl radical scavenging activity (DPPH•), and ferric reducing antioxidant power (FRAP)) of extracts prepared with DES were investigated with an experimental design and optimization study conducted for this purpose. An extraction time of 40.15 min was determined as the optimal condition. Under these conditions, a molar ratio of 3:1 (acetic acid:choline chloride) and a water ratio of 42.17 % provided the highest phenolic/flavonoid compounds and antioxidant activity. Correlations between water ratio, molar ratio, and sonication extraction time were determined using principal component analysis (PCA). In conditions where TPC, FRAP, and DPPH• were high according to PCA, it can be concluded that the extraction time, water ratio, and molar ratio are at high levels; contrarily, TFC is at a low level. In conclusion, ultrasound-assisted extraction using DES proved effective for salsify. Therefore, choline chloride-based DESs, can be recommended as environmentally friendly green solvents and an alternative to organic solvents for the extraction of bioactive compounds from salsify.
AtıfScopus11WoS8OpenAlex10İncele - MakaleAçık Erişim2024Scopus SJRQ1The application of deep eutectic solvents for protein extraction from bee bread (Perga)
Ecem Bayram, Nesrin; Gerçek, Yusuf Can; Kutlu, Naciye; Çelik, Saffet; Bayram, Sinan; Baştürk, Fatma Nur; Yıldırım, Nazlıcan
Bee bread is one of the basic nutrients that bees use as a protein source and is formed as a result of the fermentation of bee pollen. In the last few years, this product has become increasingly recognized and consumed among bee products due to its functional properties. However, deep eutectic solvents (DES) have attracted great interest in recent years as promising green alternatives to replace traditional solvents due to their variable viscosity, low vapor pressure, application-specific adjustability, non-flammability and chemical stability. In this study, bee bread was extracted in 12 different DES with different hydrogen bond acceptor (HBA):hydrogen bond donor (HBD) combinations. The DES combination with the highest total protein content was determined to be choline chloride (ChCl)-urea. Then, ultrasonic extraction conditions were optimized for maximum bioactive extraction in extracts prepared with ChCl-urea. The optimum conditions were found as 31.3 %, 25 min, 35 °C for ultrasonic power, extraction time and temperature, respectively. The desirability value (d) of the model was 0.83. The extracts were analyzed for total phenolic content, total protein content, individual polyphenolics, individual amino acids and individual vitamins as well as antimicrobial and antioxidant activity tests. According to the results, total protein, total individual amino acids and total individual phenolics were higher in the extracts obtained with ChCl-urea compared to the extract prepared with conventional solvent (ethanol). In conclusion, all these findings showed that ChCl-urea combination can be an alternative to ethanol depending on the structural characteristics of the target compounds to be extracted from bee bread.
AtıfScopus15WoS12OpenAlex13İncele - MakaleYalnız künye2024Scopus SJRQ1Mindfulness-based cognitive therapy for adherence of immunosuppressive treatment in liver transplant recipients: A randomized controlled trial
Bulbuloglu, Semra; Gunes, Hüseyin
Objective: The aim of this study was to analyze the effects of mindfulness-based cognitive therapy on the adherence of liver transplant recipients to immunosuppressive therapy with a randomized controlled design. Method: This randomized controlled trial was performed with 120 liver transplant recipients hospitalized at the liver transplant department of a research and practice hospital (n = 120). While we administered no intervention to the patients in the control group (n = 60), we provided Mindfulness-Based Cognitive Therapy to those in the experimental group (n = 60). We used the Mindful Attention Awareness Scale and the Immunosuppressant Therapy Adherence Scale to collect data. We utilized descriptive statistics, paired-samples t-tests, independent-samples t-tests, one-way analysis of variance, and chi-squared tests to analyze the data. Results: After the intervention, the immunosuppressive therapy adherence levels of the experimental group increased significantly (p < 0.01). On the other hand, the control group had significantly higher adherence to immunosuppressive therapy and significantly higher levels of mindfulness in the pretest phase than it did in the posttest phase (p < 0.01). Conclusions: Complete adherence to immunosuppressive therapy is imperative for the prevention of graft rejection in liver transplant recipients. In our study, the experimental group equipped with enhanced mindfulness had higher adherence to immunosuppressive therapy. Therefore, the use of Mindfulness-Based Cognitive Therapy in the promotion of adherence to immunosuppressive therapy is recommended.
AtıfScopus6WoS5OpenAlex7İncele - MakaleAçık Erişim2024Scopus SJRQ1The Effects of Virtual Reality Intervention Before Total Knee Arthroplasty on Pain, Anxiety, and Vital Signs
Güneş, Hüseyin; Sarıtaş, Serdar
Objective: In this study, the effects of a virtual reality intervention before total knee arthroplasty on pain, anxiety, and vital signs were investigated. Methods: This randomized controlled study with a pretest-posttest design was conducted with 130 patients included in experimental (n = 65) and control (n = 65) groups. Data were collected using a patient information form, the numeric rating scale (NRS), a vital signs form, and the state anxiety inventory. The patients in the experimental group watched a 20-minute video consisting of sea, forest, waterfall, and animal visuals using virtual reality goggles. Vital signs were recorded before and after the intervention. Vital signs were recorded on the same timeline in the control group, without any intervention. Results: The patients in the experimental group displayed lowered anxiety and pain levels and improvements in their vital signs, except for temperature. There were statistically significant differences between the experimental and control groups, except for temperature and diastolic blood pressure (p < .05). Conclusion: The virtual reality intervention reduced pain, anxiety, systolic and diastolic blood pressure, heart rate, and respiratory rate. It is recommended to be implemented before surgery.
AtıfScopus9WoS8OpenAlex11İncele - MakaleYayıncıda açık erişim2023Scopus SJRQ2A randomized controlled trial of reflexology effect after abdominal surgery on patient satisfaction, pain and vital signs
Kapıkıran, Gürkan; Bulbuloglu, Semra; Gunes, Huseyin; Saritaş, Serdar; Demir, Bilsev
Objective: In our study, we investigated the effect of reflexology on patient satisfaction, pain and vital signs after abdominal surgery. Method: This study was conducted as a randomized controlled trial with the participation of 156 abdominal surgery patients hospitalized in the general surgery unit of a training and research hospital. Personal Information Form, Visual Analogue Scale and Newcastle Nursing Care Satisfaction Scale were used in data collection. We performed the data analysis with One-way analysis of variance, Chi-squared test, paired samples t-test, and independent samples t-test. Results: When the pain, vital signs and satisfaction levels of the experimental and control groups were compared, the pain intensity of the experimental group was found to be lower and the level of satisfaction was higher after reflexology (p<0.01). After reflexology, the blood pressure was closer to 120/80 in the experimental group, the respiratory rate was between 16-22 (number/minute), the difference between the experimental and control groups were statistically significant (p<0.01). There was no statistically significant difference between the pulce oximetry values between the experimental and control groups. Conclusion: Surgical pain and non-optimal vital signs that are not well managed after surgery causes various complications and decrease patient satisfaction. The results of our study emphasize the power of reflexology in effective surgical pain management and normalizing vital signs and increasing patient satisfaction. We suggest that reflexology be performed to patients following abdominal surgery.
AtıfScopus8WoS7OpenAlex10İncele - MakaleYayıncıda açık erişim2022Scopus SJRQ4Investigation of CYP2E1 and Caspase-3 Gene Expressions in COVID-19 patients
Karabulut Uzuncakmak, S.; Dirican, E.; Naldan, M.E.; Kesmez Can, F.; Halıcı, Z.
Background: COVID-19 pandemic spread around the world like an infectious disease that presents waved effects on patients. Some patients needed ICU and respiratory support. Some patients only had flu-like symptoms. Cytokine storm and elevated ROS were serious problems for treatment. Apoptotic genes and CYP Family are part of these mechanisms. Aim: In this study, our aim was to examine the gene expression CYP2E1 and Caspase-3 in patients with COVID-19 infection. Method: 60 COVID-19(+) patients (ICU and non-ICU patients) and 30 healthy volunteers were enrolled to study. To measure the level of gene expression qPCR was used. The 2-ΔΔCt method was utilized to analyze gene expression. Results: The expression of CYP2E1 and Caspase-3 genes showed a significant discrepancy between patients and healthy individuals. Caspase-3 expression increased (p=0,0041) but CYP2E1 expression decreased (p=0,0214) in COVID-19 patients compared to healthy individuals. Both levels of gene expression were lower in patients with affected lungs than patients with unaffected lungs (p<0,05). Laboratory findings including d-Dimer, LDH, platelet count, lymphocyte count were related to both gene expressions (p<0,05). We found no correlation between CYP2E1 and Caspase-3 expressions. Conclusion: The expression of Caspase-3 demonstrated apoptotic situations of patients but was not related to the CYP2E1 expression level. CYP2E1 gene expression is an important actor to metabolize endogens and xenobiotics however, COVID-19 patients demonstrated decreased CYP2E1 expression. CYP2E1 and Caspase-3 gene expression levels may be used as a diagnostic tool for COVID-19 patients.
AtıfScopus8WoS5OpenAlex7İncele - MakaleYalnız künye2021Scopus SJRQ1Learning trajectory of a student with learning disabilities for the concept of length: A teaching experiment
Güven Akdeniz, Dilşad; Argün, Ziya
This study aims to map the learning trajectory (LT) of a student with learning disabilities (LDs) regarding the unit concept in length measurement and the usage of rulers. The article draws on data from a teaching experiment with a 10-year-old student with LDs in Turkey. Data were analyzed in two stages, including microanalysis, where each successive teaching session was separately analyzed, and macroanalysis, where the teaching sessions regarding interrelated instructional goals were analyzed to construct the LT. The main findings of the study illustrate that this student with LDs eliminated her misconceptions about the unit concept and using a ruler, accomplished the determined instructional goals to a large extent, and reached a higher level of thinking with a 4-month teaching experiment designed based on her specific developmental capacity.
AtıfScopus9WoS2OpenAlex8İncele - MakaleYayıncıda açık erişim2020Scopus SJRQ2Effects of an Essential Oil Mixture Added to Drinking Water for Temperature-Stressed Broilers: Performance, Meat Quality, and Thiobarbituric Acid-Reactive Substances
Tekce, E.; Çınar, K.; Bayraktar, B.; Takma, Ç.; Gül, M.
This study investigated the effects of an essential oil mixture (EOM; Eucalyptus globulus labill, Tymus vulgaris, Cymbopogon nardus, and Syzgium aromaticum) added to drinking water on temperature-stressed broilers. The performance parameters (body weight, average daily weight, feed intake, and feed conversion ratio), meat quality, and thiobarbituric acid-reactive substances (TBARS) were evaluated. In a 42-d study, 400 Ross-308 male chickens (1-d-old) were randomly assigned to 8 different groups (n = 50), each containing 4 subgroups (n = 8) (22°C Control (C), C + 250 mL/1,000 L, C + 500 mL/1,000 L, C + 750 mL/1,000 L), 36°C (stress control (SC), SC + 250 mL/1,000 L, SC + 500 mL/1,000 L, SC + 750 mL/1,000 L). Adding 750 mL/1,000 L at 22°C and 250 mL/1,000 L at 36°C was more beneficial to the fattening performance parameters than those in the control group. EOM reduced liver weight but increased abdominal fat in the SEOM-250 groups but did not affect other organ weights. EOM had no effect on the TBARS or the b* color parameter while it augmented the a* and L* coordinates of meat color.
AtıfScopus29WoS25OpenAlex23İncele - MakaleAçık Erişim2020Scopus SJRQ4Investigation of alterations in PIK3CA and OCT-4 gene expression in breast cancer
Dirican, Ebubekir; Kankaya, Burak; Büyükaşık, Süleyman; Alış, Halil; Velidedeoğlu, Mehmet; İlvan, Sennur; İlvan, Ahmet
Breast cancer (BCa) is one of the most prevalent cancer amongst women and PIK3CA mutations have a crucial role in carcinogenesis. On the other hand, Octamer-Binding Transcription Factor 4 (OCT-4) is common biomarkers of cancer stem cells, which provide to the pathological processes of numerous carcinomas. In this study, we evaluated the association of OCT-4 gene expression levels with the PIK3CA mutation in BCa patients. The mRNA expression level of the OCT-4 gene was detected by qPCR in 44 BCa patients and 30 BCa patients control have positive PIK3CA mutations. Exon 9 and exon 20 of PIK3CA mutations were identified by sequencing. OCT-4 gene expression and PIK3CA mutations were also clinically evaluated in BCa patients. The frequency of PIK3CA mutation in 44 new cases were 32%. PIK3CA mutations were significantly associated with HER2-positive (p = 0.0271) status, Ki-67 status (p = 0.0434) and patient age (p = 0.0149). OCT-4 mRNA expression was significantly higher in the BCa tissue in comparison to normal breast tissue (p = 0.0305). A significant correlation was found between expression of OCT-4 and node status (p = 0.0190). OCT-4 mRNA expression was higher in the PIK3CA mutation tissue than the wild type tissue. However, no association was found between the expression of OCT-4 and the PIK3CA mutation or wild type samples (p = 0.7908). Our results provided that OCT-4 gene and PIK3CA mutations may have a role in development of BCa. OCT-4 mRNA expression level and PIK3CA mutations have a potential important for BCa diagnosis or treatment.
AtıfScopus1WoS1OpenAlex1İncele