Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Dertli, Enes(117)
- Kaya, Yunus(51)
- Şahin, Engin(48)
- İspirli, Hümeyra(47)
- Özen, Soner(46)
- Şenay, Volkan(45)
- Pat, Suat(44)
- Can, Zehra(39)
- Bayraktar, Bülent(37)
- Bayram, Sinan(37)
- Korkmaz, Şadan(36)
- Cuce, Erdem(35)
- Ecem Bayram, Nesrin(33)
- Kutlu, Naciye(33)
- Yilmaz, Mustafa Tahsin(32)
- Artar, Musa(31)
- Ertugrul, Mehmet(30)
- Öner, Erdal(30)
- Ayata, Ümit(29)
- Hasar, Ugur Cem(29)
- Esmer, Yusuf(28)
- Mercan, Emin(27)
- Cuce, Pinar Mert(26)
- Özdemir, Akın(25)
- Çolak, Murat(24)
- Bayram, Ozkan(23)
- Kamiloğlu, Aybike(23)
- Sert, Durmuş(22)
- Ayazoglu, Rabil(21)
- Abdioglu, Murat(20)
- Bayram, Nesrin Ecem(20)
- Kadakal, Mahir(20)
- Kara, Yakup(20)
- Kizil, Hamit Emre(20)
- Tozlu, Alperen(20)
- Birinci, Ahmet(19)
- Gerçek, Yusuf Can(19)
- Battal, Fetullah(18)
- Dirican, Ebubekir(18)
- Ergün, Mustafa(18)
Yayınlar
- MakaleYalnız künye2024Scopus SJRQ3Artificial Neural Network and Multiple RegresAnalysis Applied to 2D-QSAR Studies: the Caof Imidazolidine-2,4-dione as PTP1B Inhibito
Aggoun, Siham; Belaidi, Salah; Ghamri, Meriam; Kerassa, Aicha; Cinar, Mehmet; Yamari, Imane; Abchir, Oussama; Chtita, Samir
In this investigation, we undertook a comprehensive quantitative structure-activity relationship (QSAR) analysis using both modern artificial neural network (ANN) methods and classical multiple linear regression methods (MLR). Our primary focus was on revealing the intricate connection between antidiabetic activity and the molecular structure of thirty-nine imidazolidine-2,4-dione derivatives. The B3LYP hybrid functional and 6-31G (d) basis set computed electronic properties at the quantum level. Rigorous benchmarking against experimental data validated the reliability of our quantum theory approach. Our statistical model effectively predicted activities closely aligned with experimental antidiabetic activities, quantified by the IC50 values. They also revealed a significant superiority of the ANN architecture (6-4-1) over the MLR method. This study stands as a meaningful contribution to the field, providing valuable insights for designing new antidiabetic drugs, particularly as potential inhibitors of tyrosine phosphate 1B (PTP1B). The explicit articulation of our primary aim and emphasis on the study’s significance underscore its potential impact on advancing drug development within the realm of antidiabetic therapeutics.
AtıfScopus2
İncele - Derleme MakaleAçık Erişim2024Scopus SJRQ1Oxidative stability, quality, and bioactive compounds of oils obtained by ultrasound and microwave-assisted oil extraction
Walayat, Noman; Yurdunuseven-Yıldız, Aysun; Kumar, Manoj; Goksen, Gulden; Öztekin, Sebahat; Lorenzo, José Manuel
Vegetable oils are extracted from oilseeds, fruits and other parts of plants. The method used in oil extraction is of great importance, as it affects both the quality of the final product and the environment. It is desirable that the extraction method be minimally costly, fast, environmentally friendly, and produce oil of high quality and quantity. Common oil extraction methods are mechanical pressing and solvent extraction, and these methods have advantages and disadvantages over each other. Mechanical extraction and solvent extraction are controversial due to poor product quality and high environmental impacts. This review presents applications where conventional oil extraction processes are assisted by microwave or ultrasound. It is necessary to evaluate the impact of ultrasound and microwave-assisted extraction on the quality of the extracted oil and also to compare the results with those of conventional extraction methods. For this purpose, this review discusses the effects of microwave and ultrasound-assisted extraction on the physicochemical, oxidation indices, bioactive compounds, and antioxidant properties of oil extracted from oil seeds and fruits. Furthermore, this review provides readers with in-depth information on the mechanisms involved, their use, and the impact of operating conditions. The yield and quality of the oil obtained by these processes can vary depending on parameters such as microwave power, ultrasound power, processing time, and temperature. Finally, the review also discusses the challenges and advantages of the industrial application of these technologies.
AtıfScopus47WoS41OpenAlex45
İncele - MakaleAçık Erişim2024Scopus SJRQ3The relationship between parental awareness of sexual abuse and children's skills to say «no»; [Relación entre la conciencia de madres y padres sobre el abuso sexual y las habilidades de los niños para decir «no»]
Kirbaş, Zila Özlem; Şahin, Emel
Introduction: Child sexual abuse is a global and multidimensional social problem and causes devastating and permanent psychological, emotional, cognitive, behavioural, physical, sexual and interpersonal sequelae. This study examines the relationship between the ability to say «no» and parental awareness of sexual abuse in 4th grade primary school students. Methods: The study was conducted between April 2022 and June 2022 in primary schools in the central district of a province in north-eastern Turkey. The sample consisted of 310 students enrolled in 4th grade and their parents. We collected the data through a personal information form, the ability to say «no» scale for children and the sexual abuse awareness scale for parents. Results: There was a weak positive correlation between the mean maternal scores of sexual abuse awareness and the mean scores of refusal and resistance in children (P ˂ .05), as well as a weak positive correlation between the mean paternal scores of sexual abuse awareness and the mean scores of refusal and resistance in children (P ˂ .05). Conclusion: As mothers’ and fathers’ awareness of sexual abuse myths and of teachings and actions to combat sexual abuse increased, the refusal of children also increased. Also, as fathers’ awareness of the signs of sexual abuse increased, children's refusal increased.
AtıfScopus3WoS2OpenAlex3İncele - Derleme MakaleAçık Erişim2024Scopus SJRQ1Quality and stability of frying oils and fried foods in ultrasound and microwave–assisted frying processes and hybrid technologies
Yildiz, Aysun Yurdunuseven; Echegaray, Noemí; Öztekin, Sebahat; Lorenzo, José Manuel
Frying is a popular cooking method that produces delicious and crispy foods but can also lead to oil degradation and the formation of health-detrimental compounds in the dishes. Chemical reactions such as oxidation, hydrolysis, and polymerization contribute to these changes. In this context, emerging technologies like ultrasound-assisted frying (USF) and microwave (MW)-assisted frying show promise in enhancing the quality and stability of frying oils and fried foods. This review examines the impact of these innovative technologies, delving into the principles of these processes, their influence on the chemical composition of oils, and their implications for the overall quality of fried food products with a focus on reducing oil degradation and enhancing the nutritional and sensory properties of the fried food. Additionally, the article initially addresses the various reactions occurring in oils during the frying process and their influencing factors. The advantages and challenges of USF and MW-assisted frying are also highlighted in comparison to traditional frying methods, demonstrating how these innovative techniques have the potential to improve the quality and stability of oils and fried foods.
AtıfScopus35WoS33OpenAlex39İncele - MakaleAçık Erişim2024Scopus SJRQ1FR2/mmWave, N258 and N261 Bands, 5G Frequency-Compatible Ultra-Thin Metamaterial Absorber with Polarization Insensitivity for EMI shielding Applications
Teber, Ahmet
Since adopting 5G technology, a notable rise in the prevalence of electromagnetic (EM) waves in the environment has become a significant concern. To reduce EM interference, broadband metamaterial absorbers offer an alternative solution for protecting devices in defense, communication, and healthcare applications, unlike their narrowband counterparts. This article presents a numerical investigation of an ultra-thin, polarization-insensitive metamaterial absorber (MMA) that uses metasurfaces and provides electromagnetic interference (EMI) reduction, covering the FR2/mmWave licensed N258 and N261 bands with an oblique incidence angle of up to 15 degrees. Comprehensive simulations are performed within the CST Studio Suite S2 2023 to examine the absorber's performance. Under normal incidence, the proposed MMA exhibits a wideband absorbency response exceeding 90% within the frequency range of 24.30–28.12 GHz. Moreover, the physical absorption mechanism is explained with electric and magnetic field distributions, including surface current distributions. Confirmation of the lack of mutual interaction among neighboring unit cells is established through testing with 1 × 2 and 2 × 2 arrays. An equivalent circuit model is also developed to confirm the EM simulation findings. The notable features of the proposed MMA make it an exceptional candidate for EM shielding applications, providing EMI reduction and covering the N258 and N261 bands.
AtıfScopus7WoS3OpenAlex5İncele - MakaleAçık Erişim2024Scopus SJRQ3Machine learning driven optimization and parameter selection of multi-surface HTS Maglev
Ozkat, Erkan Caner; Abdioglu, Murat; Ozturk, U. Kemal
This research aims to tackle the challenges posed by precise force measurement for high temperature superconducting (HTS) Maglev systems, including mechanical constraints, step motor limitations, and sensor resolutions. For this aim, six machine learning (ML) models namely Support Vector Machine (SVM), Gaussian Process Regression (GPR), Extreme Gradient Boosting (XGB), Long Short-Term Memory (LSTM), Extreme Machine Learning (EML), and Convolutional Neural Network (CNN) were developed to predict levitation force (Fz) and lateral force (Fx) based on process parameters including permanent magnet width (PMW), field cooling height (FCH), the movement in the z-axis (vertical distance), and the movement in the x-axis (lateral distance). Among six ML models, CNN emerged as the most accurate model, demonstrating smaller root mean square deviation (RMSD) without compromising correlation coefficients. Furthermore, an innovative process window approach was introduced to select process parameters that simultaneously meet the minimum value of Fz and maximum value of Fx, named β1 and β2, set at 90 N and 0 N, respectively. Within this window, PMW of 30 mm and z values less than 10 mm were found to be consistent for all FCH and x values. The novelty of this study is to formulate the optimisation problem in HTS Maglev using the developed ML model by addressing two specific objectives one of which focuses on maximizing Fz while ensuring Fx remains within a defined tolerance (β3), representing the minimum allowable ratio of the levitation force to the total force, and the second problem aims to maximize Fz while obtaining zero Fx. The optimum PMW, FCH, x, and z values were obtained at 30 mm, 30 mm, 4 mm and 5 mm, corresponding to Fz and Fx values of 224.2 N and -53.8 N for option 1. As for option 2, the process parameters were obtained as 28.6 mm, 25.9 mm, 0 mm, and 5 mm, corresponding to Fz and Fx values of 194.2 N and 0 N. It was obtained both experimentally and by the optimization that Fz reaches close its maximum as the Fx gains attractive character. Hence, it is expected that the outcomes of this study will significantly benefit the design of HTS Maglev systems and find valuable applications across various transportation engineering projects.
AtıfScopus21WoS18İncele - MakaleYalnız künye2024Scopus SJRQ1Research of the crack problem of a functionally graded layer
Yaylacı, Murat; Yaylacı, Ecren Uzun; Turan, Muhittin; Özdemir, Mehmet Emin; Öztürk, Şevval; Ay, Sevil
In this study, the two-dimensional crack problem was investigated by using the finite element method (FEM)based ANSYS package program and the artificial neural network (ANN)-based multilayer perceptron (MLP) method. For this purpose, a half-infinite functionally graded (FG) layer with a crack pressed through two rigid blocks was analyzed using FEM and ANN. Mass forces and friction were neglected in the solution. To control the validity of the crack problem model exercised, the acquired results were compared with a study in the literature. In addition, FEM and ANN results were checked using Root Mean Square Error (RMSE) and coefficient of determination (R2), and a well agreement was found. Numerical solutions were made considering different geometric parameters and material properties. The stress intensity factor (SIF) was examined for these values, and the results were presented. Consequently, it is concluded that the considered non-dimensional quantities have a noteworthy influence on the SIF. Also FEM and ANN can be logical alternative methods to time-consuming analytical solutions if used correctly.
AtıfScopus27WoS30OpenAlex6İncele - MakaleYalnız künye2024Scopus SJRQ1Effective biocatalytic synthesis of enentiopure (R)-1,2-diphenylethanol as a pharmaceutical precursor using whole-cell biocatalyst
Çakmak, Fadile; Özdemir, Akın; Dertli, Enes; Şahin, Engin
Optically active alcohols are crucial precursors. 1,2-Diarylethanols and their analogues constitute a significant group of substances of biological significance. The biocatalytic synthesis of (R)-1,2-diphenylethanol ((R)-2), which can be utilized as a precursor to important drugs, is still not at the desired level in terms of substrate amount and production process. This study asymmetrically reduced 1,2-diphenylethanone (1) using the Lactobacillus paracasei BD87E6 biocatalyst and a novel orthogonal quadratic design-embedded optimization approach. The following reaction optimization conditions were determined using the suggested optimization technique: pH = 6, temperature = 31 °C, incubation period = 48 h, and agitation speed=134 rpm. In addition, the reaction conversion was estimated to be 99.38 %, and the product's enantiomeric excess (ee) was estimated to be 99.12 %. Further, (R)-2 was produced with >99 % ee, >99 % conversion, and 98 % yield in the experimental investigation under the established optimum conditions. This study is the first attempt to reduce substrate 1 to (R) or (S)-2 using a mathematical optimization method in the presence of a biocatalyst. Furthermore, on a high-gram scale, 1 (15.70 g) was entirely transformed into (R)-2 (15.54 g, 98 % isolated yield). Notably, this study is also the first to perform the gram-scale production of (R)-2 using a novel optimization approach and a biocatalyst. Finally, the innovative and novel orthogonal quadratic design-embedded optimization technique has been demonstrated as an efficient, cost-effective, and environmentally friendly biocatalytic procedure for synthesizing (R)-2.
AtıfScopus7WoS7OpenAlex6İncele - MakaleAçık Erişim2024Scopus SJRQ1Virtual Reality Technology in Nursing Education: A Qualitative Study
Avşar, Gülçin; Çelik, Şeymanur; Doğan, Sevgi; Çiftçi, Bahar
Virtual reality (VR) technology plays a significant role in nursing education by enhancing the quality of training by applying knowledge, decision-making, intervention completion and feedback. This study aims to examine nursing students' experiences and perceptions regarding the ventrogluteal injection training provided through VR technology. Conducted between May and June 2022, this qualitative descriptive phenomenology study took place at a state university in Turkey, involving 70 students who participated in Ventrogluteal Drug Administration training using VR glasses. The sample included 12 students selected via the Criterion Sampling Method. Data collection tools comprised the ‘Descriptive Information Form’ and a ‘Semi-Structured Questionnaire’. Qualitative data were analysed using the Content Analysis Method, while quantitative data were assessed through descriptive statistical methods (frequency, percentage, mean). The study identified 13 codes, four sub-themes and two main themes from the students' evaluations. The first main theme, ‘Weaknesses of Virtual Simulation’, included two sub-themes: ‘Due to its Nature’ and ‘Due to its Technique’, resulting in five codes. The second main theme, ‘Strengths of Virtual Simulation’, was divided into two sub-themes: ‘Permanence, Integrity, and Applicability’ and ‘Emotions towards Virtual Simulation’, with eight codes identified. The findings indicate that students view VR technology positively in their education. However, they also highlighted specific issues related to the simulation's technique and inherent nature.
AtıfScopus5WoS4OpenAlex6İncele - Kitap BölümüAçık Erişim2024Phenolic Acids in Pollen
Kostić, Aleksandar Ž.; Gercek, Yusuf Can; Bayram, Nesrin Ecem
Determination of phenolic composition of pollen has been one of the most popular topics over the past decade. Although most research studies focused on bee-collected pollen samples, it was also observed that phenolics, in particular, phenolic acids, are very important as protecting compounds in floral pollen grain, attached to sporopollenin. Based on the collected data a pronounced diversity of phenolic acids and derivatives was observed in pollen samples with different botanical/geographical origin. In total, 23 phenolic acids were identified/quantified in the samples with great predominance of the following ones: caffeic acid (0.04–450 μg/g), ferulic acid (0.27–450 μg/g) and p-coumaric acid (0.14–410 μg/g). However, the highest content was observed for vanillic acid (4985.5 μg/g) in the rape bee-collected pollen (China). In addition, several different derivatives, such as ethers, esters or amides, were also identified in pollen.
AtıfScopus9OpenAlex5İncele - MakaleAçık Erişim2024Scopus SJRQ1Analysis of cascade vapor compression refrigeration system using nanorefrigerants: Energy, exergy, and environmental (3E)
Yilmaz, Metin; Cimsit, Canan; Keven, Arzu; Karaali, Rabi
Nanorefrigerants are considered the most efficient heat transfer fluids for improving heat transfer properties in the refrigeration and air conditioning equipment. For the first time in this study, energy, exergy, and environmental evaluation (3E) analyses were performed by the addition of different nanoparticles to a low GWP refrigerant pair such as R290/R1233ZDE in a cascade refrigeration system. CNT, CuO, and, TiO2 nanoparticles were added to the refrigerant. The effect of nanoparticles on the cascade refrigeration system was analyzed using a model based on density changes. A detailed thermodynamic analysis was performed of the cascade refrigeration system at different evaporator temperatures and mass ratios. The power consumption of the compressor decreases as the evaporator temperature increases for all types of nanoparticles, resulting in an increase in COP values. The analyses showed that CuO nanoparticles had the highest performance. It has been observed that the energy and exergy efficiency increase as compressor work decreases with increasing mass ratios in all nanorefrigerants. In addition, the results indicated that all nanorefrigerants emit lower monthly CO2 emissions compared to the pure refrigerants. The nanorefrigerants play a crucial role in reducing energy consumption and promoting environmental protection compared to traditional refrigerants.
AtıfScopus16WoS16OpenAlex17İncele - MakaleAçık Erişim2024Scopus SJRQ1The application of deep eutectic solvents for protein extraction from bee bread (Perga)
Ecem Bayram, Nesrin; Gerçek, Yusuf Can; Kutlu, Naciye; Çelik, Saffet; Bayram, Sinan; Baştürk, Fatma Nur; Yıldırım, Nazlıcan
Bee bread is one of the basic nutrients that bees use as a protein source and is formed as a result of the fermentation of bee pollen. In the last few years, this product has become increasingly recognized and consumed among bee products due to its functional properties. However, deep eutectic solvents (DES) have attracted great interest in recent years as promising green alternatives to replace traditional solvents due to their variable viscosity, low vapor pressure, application-specific adjustability, non-flammability and chemical stability. In this study, bee bread was extracted in 12 different DES with different hydrogen bond acceptor (HBA):hydrogen bond donor (HBD) combinations. The DES combination with the highest total protein content was determined to be choline chloride (ChCl)-urea. Then, ultrasonic extraction conditions were optimized for maximum bioactive extraction in extracts prepared with ChCl-urea. The optimum conditions were found as 31.3 %, 25 min, 35 °C for ultrasonic power, extraction time and temperature, respectively. The desirability value (d) of the model was 0.83. The extracts were analyzed for total phenolic content, total protein content, individual polyphenolics, individual amino acids and individual vitamins as well as antimicrobial and antioxidant activity tests. According to the results, total protein, total individual amino acids and total individual phenolics were higher in the extracts obtained with ChCl-urea compared to the extract prepared with conventional solvent (ethanol). In conclusion, all these findings showed that ChCl-urea combination can be an alternative to ethanol depending on the structural characteristics of the target compounds to be extracted from bee bread.
AtıfScopus15WoS12OpenAlex13İncele - MakaleYalnız künye2024Scopus SJRQ3Microwave hydrodistillation of Pelargonium graveolens L’Her leaves: Essential oil profile, phytochemical composition of wastewater, histo-anatomical structure
Boztaş, Kadir; Gercek, Yusuf Can; Türer, Gizem; Canlı, Deniz; Bayram, Sinan; Çelik, Saffet; Kırkıncı, Seran; Basturk, Fatma Nur; Feizollahi, Sepideh; Cevahir Öz, Gül
By-products with remarkable bioactive properties are formed in extraction processes of essential oils from plant materials. In present study, it was aimed to determine the concentration of individual phenolic and organic acid compounds by LC-MS/MS of the by-product (wastewater) collected after the essential oil isolation from Pelargonium graveolens L. and to determine some bioactive properties of this by-product. In addition, the chemical analysis and antibacterial activity of the essential oil extracted from P. graveolens were determined and the histo-anatomical characterization of the glandular trichomes in the leaf sample was performed. As a result, quercetin (95862.22 μg/kg), myricetin (59834.32 μg/kg) and rutin (36522.90 μg/kg) were the phenolic compounds determined in the highest concentrations in the by-product extracted using two different extraction techniques (non-hydrolysis and hydrolysis methods). Moreover, the individual organic acids of the by-product screened in LC-MS/MS was found to be 4487.17 mg/kg in total. When the essential oil component profile of the plant sample was examined, the citronellol (38.78%) compound was found to be dominant, and it was also detected that the essential oil had remarkable bioactive properties. In conclusion, it can be stated that both the essential oil obtained from P. graveolens and the by-product obtained during essential oil isolation can be considered as a source of some bioactive components in many different industrial applications.
AtıfScopus6WoS4OpenAlex6İncele - MakaleAçık Erişim2024Scopus SJRQ1The Effect of Augmented Reality Technology on Primary School Students’ Achievement, Attitudes Towards the Course, Attitudes Towards Technology, and Participation in Classroom Activities
Sökmen, Yavuz; Sarikaya, İsmail; Nalçacı, Ahmet
The research aims to investigate the impact of augmented reality (AR) technologies developed within the framework of primary school students’ on student achievement, attitudes towards the course, attitudes towards technology, and participation in classroom activities. The contents of AR-based learning materials have been developed by 4th-grade teachers and writers within the context of the existing curriculum. The study process was carried out based on the instructional design model. The research was performed in conjunction with the quasi-experimental design among the experimental designs of quantitative research methods. Using the cluster random sampling method, students in the experimental and control groups were selected among 11 primary schools. The findings indicate that contrary to the students in the control group, the students in the experimental group had higher academic achievement and participation in classroom activities, and also their attitudes to the course and applied technology were more positive. Moreover, concerning the experimental group students, a positive and significant correlation between their academic achievements, attitudes towards the course, attitudes towards technology, and their participation and participation in classroom activities have been observed.
AtıfScopus24WoS16OpenAlex21İncele - MakaleAçık Erişim2024Scopus SJRQ2Biochemical and physicochemical characteristics and volatile profiles of Erzincan Tulum cheese coagulated by herb-fortified artisanal lamb rennet
Arslaner, Ayla; Türkmen, Özgenur
The characteristics of Erzincan Tulum cheese (ETC), an artisanal ewe-milk cheese and the first cheese with the designation of origin in Türkiye, are closely related to the geographical location of production and the human factors influencing every stage of the production process. This study aims to determine the influence of different coagulants (namely, herb-fortified artisanal lamb rennet (ALR), artisanal calf rennet (ACR), and commercial calf rennet (CCR)) on the biochemical, physicochemical characteristics, and volatile compounds of ETC, produced on the Heybeli plateau of the Erzincan province. Using artisanal rennet increased total solids, fat content, and acidity while decreasing pH and aw values. The highest PTA-SN (soluble nitrogen in 5 % phosphotungstic acid, w/v) and TCA-SN (soluble nitrogen in 12 % trichloroacetic acid w/w) values at the end of the ripening period (day 150 of storage) were observed in the ALR-Cheese (ALR-C). Furthermore, this cheese exhibited the highest rate of lipolysis (P < 0.01). Electrophoretograms revealed that αs-1 and β-casein degradation rates were the most significant in ALR-C. Following the 30th day of storage, the highest counts of lactic acid bacteria (LAB) were found in ALR-C. The most rapid reduction of coliforms, E. coli, and yeast-mold was observed in this sample throughout the storage. Eighty-nine volatile compounds were identified in the samples. Particularly noteworthy, ALR-C exhibited the highest ratios of hexanoic, octanoic, and decanoic acids after 90 days of storage. Additionally, steroid compounds were exclusively detected in this sample. The findings of this research make a substantial contribution to the existing literature concerning rennet types and the aromatic profile of ETC. These aspects are crucial for further investigations to enhance the cheese's quality and safety.
AtıfScopus3WoS3OpenAlex3İncele - MakaleYalnız künye2024Scopus SJRQ3Exploring the Potential of Isoindole-1,3-Dione Derivatives as Novel Inhibitors of Aldose Reductase: An In Silico and In Vitro Insight into Therapeutic Strategies for Diabetic Complications
Şengül, Bülent; Gündoğdu, Özlem; Kilinç, Namık; Kishali, Nurhan
This study explores the potential of isoindole-1,3-dione derivatives as novel inhibitors of aldose reductase (AR), focusing on their in silico and in vitro effects for therapeutic strategies against diabetic complications. Aldose reductase, a critical enzyme in the polyol pathway, plays a significant role in glucose metabolism and has been linked to diabetic complications. In this comprehensive study, isoindole-1,3-dione derivatives were synthesized and evaluated for their inhibitory effects on the recombinant human AR enzyme. The compounds’ inhibitory activities were measured both in vitro and through in silico techniques, employing molecular docking and free binding energy calculations and ADME studies. The newly synthesized compounds demonstrated varied inhibitory effects, with ethyl and phenyl substituents at specific positions enhancing inhibitory activity. Notably, compounds with carboxylic acid derivatives exhibited potent inhibitory effects, especially compound 6 with an IC50 value of 1.649 μM. In conclusion, this study provides valuable insights into the inhibitory potential of isoindole-1,3-dione derivatives against AR, suggesting their potential therapeutic application in mitigating diabetic complications. The combination of experimental and computational approaches offers a comprehensive understanding of the compounds’ interaction mechanisms and pharmacokinetic profiles, supporting their further exploration as antidiabetic agents.
- MakaleYalnız künye2024Scopus SJRQ1Mindfulness-based cognitive therapy for adherence of immunosuppressive treatment in liver transplant recipients: A randomized controlled trial
Bulbuloglu, Semra; Gunes, Hüseyin
Objective: The aim of this study was to analyze the effects of mindfulness-based cognitive therapy on the adherence of liver transplant recipients to immunosuppressive therapy with a randomized controlled design. Method: This randomized controlled trial was performed with 120 liver transplant recipients hospitalized at the liver transplant department of a research and practice hospital (n = 120). While we administered no intervention to the patients in the control group (n = 60), we provided Mindfulness-Based Cognitive Therapy to those in the experimental group (n = 60). We used the Mindful Attention Awareness Scale and the Immunosuppressant Therapy Adherence Scale to collect data. We utilized descriptive statistics, paired-samples t-tests, independent-samples t-tests, one-way analysis of variance, and chi-squared tests to analyze the data. Results: After the intervention, the immunosuppressive therapy adherence levels of the experimental group increased significantly (p < 0.01). On the other hand, the control group had significantly higher adherence to immunosuppressive therapy and significantly higher levels of mindfulness in the pretest phase than it did in the posttest phase (p < 0.01). Conclusions: Complete adherence to immunosuppressive therapy is imperative for the prevention of graft rejection in liver transplant recipients. In our study, the experimental group equipped with enhanced mindfulness had higher adherence to immunosuppressive therapy. Therefore, the use of Mindfulness-Based Cognitive Therapy in the promotion of adherence to immunosuppressive therapy is recommended.
AtıfScopus6WoS5OpenAlex7İncele - MakaleAçık Erişim2024Scopus SJRQ2Cross-cultural adaptation and psychometric evaluation of the Turkish version of the Smombie Scale for Adolescents
Sönmez Sari, Ebru; Temel Mert, Zeynep; Semerci Çakmak, Vahide; Sevgil Atli, Pelin
Background: Smombie has become an important problem especially in terms of adolescent health. The aim of this study was to translate the Smombie Scale for Adolescents (SSA) into Turkish and to examine its psychometric properties. Methods: This study has a methodological design. The study was conducted between March and April 2024. The sample of the study consisted of 430 adolescents. The data were collected by using Personal Information Form and SSA. Content Validity Index, Confirmatory Factor Analysis (CFA), test−retest reliability, Cronbach's α coefficient, item-total score correlation, 27% upper−lower group item analysis and Hotelling T2 test were used in data analysis. Results: The four-factor structure of the scale showed a good fit in CFA (chi-square minimum discrepancy [CMIN] = 187.463, degrees of freedo (DF) = 83, CMIN/DF = 2.259, root mean square error of approximation = 0.054, root mean square residual = 0.033, goodness of fit index = 0.947, adjusted goodness of fit index = 0.923, normed fit index = 0.930, tucker-lewis index = 0.949 and comparative fit index = 0.959). Cronbach's α coefficient of the scale was found to be 0.86. The item-total score correlation of the scale was found between 0.212 and 0.721. The test-retest intraclass correlation coefficient of the scale was found to be 0.876. Conclusions: This study shows that the scale is a reliable tool for assessing adolescents' smombie tendencies. It is thought that the scale will contribute to the protection and development of adolescent health.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2024Scopus SJRQ2Investigation of the effect of green walking and intelligence games on the cognitive skills of individuals between the ages of 50–70 survived COVID-19 disease: A randomized controlled study
Akeren, Zahide; Hintistan, Sevilay
Background: Mild cognitive impairment can be considered as the preclinical stage of Alzheimer's disease. With the addition of COVID-19 disease to the cognitive decline that occurs with aging, it may cause dementia with severe cognitive losses such as Alzheimer's disease in some people. Physical activity and brain-occupying practices can significantly improve the risk factors for cognitive disorders and Alzheimer's disease. Objective: The aim of study was to examine the effect of green walking and intelligence game on the cognitive skills of individuals aged 50–70 years with COVID-19. Methods: The randomized controlled study was completed with 40 individuals, 20 in the experimental and 20 in the control group. Individuals in the experimental group green walking for 30 min three days a week for one month in two groups of 10 people, accompanied by the researcher. In addition, these individuals played intelligence games (brain games-memory thinking and brain exercise) via their smartphones for 15 min every day for a month. Results: The cognitive skills and cognitive dimensions of “attention, concentration, memory, language and orientation” of the individuals in the experimental group were significantly increased compared to the control group individuals (p < 0.05). Conclusions: It was found that green walk and intelligence game practice increased the cognitive skills of individuals aged 50–70 years who had outpatient COVID-19. © The Author(s) 2024. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
AtıfScopus1WoS2OpenAlex2İncele - MakaleAçık Erişim2024Scopus SJRQ3The effect of injectable platelet-rich fibrin in combination with autogenous bone grafts on bone healing in an ovariectomized osteoporotic rat model with critical-sized defects
Durmuşlar, Mustafa C.; Gülşen, Elif A.; Bayburt, Kemal A.; Ballı, Umut; Ocak, Mert; Fırat, Ayşegül; Zırh, Elham B.; Çelik, Hakan H.
OBJECTIVES: To assess the impact of autogenous graft materials, including autogenous bone graft (ABG) and injectable platelet-rich fibrin (I-PRF) clots, on bone defect regeneration in ovariectomized osteoporotic rats. METHODS: Wistar rats (6-8 weeks old) were ovariectomized, and surgery began after 8 weeks. A 5-mm defect was created bilaterally in the parietal bones of 16 rats, which were divided into 4 groups. Group A (blank) had untreated defects; group B had defects filled with 0.1 ml of I-PRF, group C had defects filled with 0.1 ml of ABG, and group D had defects filled with a combination of 0.1 ml each of I-PRF and ABG. Four weeks post-surgery, the rats were euthanized. Bone regeneration was evaluated through histopathologic analysis and microcomputed tomography (micro-CT). RESULTS: In ovariectomized rats treated with ABG or I-PRF, bone regeneration was enhanced, with increased periosteal activity, osteoblast count, and new bone volume, as determined histologically. The ABG+I-PRF group had the highest periosteal vascularity, but the difference compared to the ABG group was not statistically significant (p>0.05). Osteoblast numbers were significantly higher in the ABG+I-PRF group than in the blank group (p<0.05). Micro-CT showed the highest mean new bone volume ratio in the ABG+I-PRF group, followed by the ABG group. CONCLUSION: The combined use of ABG and I-PRF enhances bone formation in osteoporotic rats following ovariectomy. Copyright:
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