Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Dertli, Enes(117)
- Kaya, Yunus(51)
- Şahin, Engin(48)
- İspirli, Hümeyra(47)
- Özen, Soner(46)
- Şenay, Volkan(45)
- Pat, Suat(44)
- Can, Zehra(39)
- Bayraktar, Bülent(37)
- Bayram, Sinan(37)
- Korkmaz, Şadan(36)
- Cuce, Erdem(35)
- Ecem Bayram, Nesrin(33)
- Kutlu, Naciye(33)
- Yilmaz, Mustafa Tahsin(32)
- Artar, Musa(31)
- Ertugrul, Mehmet(30)
- Öner, Erdal(30)
- Ayata, Ümit(29)
- Hasar, Ugur Cem(29)
- Esmer, Yusuf(28)
- Mercan, Emin(27)
- Cuce, Pinar Mert(26)
- Özdemir, Akın(25)
- Çolak, Murat(24)
- Bayram, Ozkan(23)
- Kamiloğlu, Aybike(23)
- Sert, Durmuş(22)
- Ayazoglu, Rabil(21)
- Abdioglu, Murat(20)
- Bayram, Nesrin Ecem(20)
- Kadakal, Mahir(20)
- Kara, Yakup(20)
- Kizil, Hamit Emre(20)
- Tozlu, Alperen(20)
- Birinci, Ahmet(19)
- Gerçek, Yusuf Can(19)
- Battal, Fetullah(18)
- Dirican, Ebubekir(18)
- Ergün, Mustafa(18)
Yayınlar
- MakaleAçık Erişim2024Scopus SJRQ3The Relationship of Mitochondrial-derived Peptide (MOTS-c) and Brain Mitochondrial Carrier Protein 1 (BMCP1) Response in Sheep with Some Physiological Parameters
Bayraktar, B.; Demir, N.; Aksakal, V.
Background: Mitochondria are organelles called power plants of the cell, which are found in eukaryotic cells and are responsible for the production of energy needed by the cells through aerobic respiration. Mitochondrial dysfunction causes endocrinological, cardiovascular, metabolic and neurodegenerative diseases. The aim of this study was to examine the effects of body condition score (BCS), lactation, pregnancy, age and gender on Mitochondrial-Derived Peptide (MOTS-c) and Brain Mitochondrial Transporter Protein 1 (BMCP1) levels in Akkaraman sheep. Methods: Sheep are classified into 3 categories according to BCS (BCS<2, BCS=3-3.5, BCS≥4). In creating groups in terms of BCS, it was determined by the palpation method applied to the waist area. The sheep included in the study were divided into 4 groups: early lactation, early pregnancy, late pregnancy (dry period) and age (female and male sheep).1st group, ewes in the first period of pregnancy (on the 100th day of the first pregnancy) (n= 30), 2nd group, ewes in the early lactation period (n= 30), 3rd group, ewes in the dry period (the last two months of pregnancy) (n= 30) and in the 4th group, <2 (young) (n=30), 2-8 (adult) (n=30), 8> (old) (n=30), male and female sheep (n=30) of different ages. =180) total of 270 animals. Blood samples were taken from the jugular vein of the sheep before the morning feeding. MOTSc and BMCP1 levels were determined in blood serum samples by ELISA method. Result: In the study, serum MOTS-c and BMCP1 levels in sheep during lactation and pregnancy were determined to be lowest in the VKS<2 group and highest in the VKS ≥4 groups. Likewise, in age and gender groups, the highest level was detected in young lambs and yearlings in the VKS<2 group, while the highest level was detected in old sheep and rams in the VKS ≥4 group. As a result, it was determined that different age, gender, pregnancy and lactation periods affected serum MOTS-c and BMCP1 levels depending on the change in BCS (P<0.05). It was concluded that MOTS-c and BMCP1 may be useful parameters in the evaluation of mitochondrial function, energy metabolism and metabolic profile.
AtıfScopus4WoS4OpenAlex2
İncele - MakaleAçık Erişim2024Scopus SJRQ1Analytical approach to contact mechanics of functionally graded orthotropic layers with gravitational considerations
Öner, Erdal; Al-Qado, Ahmed Wasfi Hasan
Contact problems involving deformable bodies are widespread in both industrial and everyday situations. They have a crucial impact on structural and mechanical systems, which has led to significant efforts in modeling and numerical simulations. These efforts aim to improve understanding and optimization in various engineering applications. This study examines the contact problem involving a functionally graded (FG) orthotropic layer resting on a rigid foundation, without considering frictional influences. A point load is applied to the layer through a rigid punch on its top surface. Additionally, the gravitational effects of the FG orthotropic layer are considered in the analyses. Material parameters and density of the FG orthotropic layer are presumed to exhibit exponential variations along the vertical axis. The resolution of the problem involves deriving stress and displacement expressions through the application of elasticity theory and integral transformation techniques. By imposing the pertinent boundary conditions onto these expressions, a singular integral equation is formulated, wherein the contact stress under the punch remains unknown. Employing the Gauss–Chebyshev integration method, this integral equation is subsequently numerically solved, particularly for a flat punch profile. The outcomes of this investigation encompass the determination of contact stresses under the punch, the critical separation load, and the critical separation point—marking the initial separation between the FG orthotropic layer and the rigid foundation. Additionally, the analysis yields dimensionless representations of normal stresses along the symmetry axis within the FG orthotropic layer, as well as shear stresses along a designated section proximate to the symmetry axis. Furthermore, it provides insights into the normal stresses along the x axis at the bottom surface of the FG orthotropic layer, contingent upon various parameters and distinct orthotropic material compositions.
AtıfScopus12WoS12OpenAlex12İncele - MakaleYalnız künye2024Scopus SJRQ2Investigation of emotion regulation skills, salivary apelin, and serotonin levels in children in Türkiye: a cross-sectional study
Kırbaş, Zila Özlem; Bayraktar, Bülent; Odabaşı Aktaş, Elif
Purpose: Little is known about the relationship between apelin and serotonin in emotion regulation. This study aimed to examine children’s emotional regulation skills and salivary apelin and serotonin levels. Methods: This is a cross-sectional study performed in Türkiye. The research was completed with the participation of 146 children, 8–10 years old, from the general population. Emotion Regulation Skills Scale for Children (CERS) was used to assess children’s levels of emotion regulation skills. Apelin and serotonin levels were examined by ELISA technique in saliva samples obtained from children. Results: A statistically significant correlation was found between the mean total score of the CERS and the mean apelin and serotonin levels (p ˂.01). We found that females had higher emotion regulation skills compared to males, older higher than younger ones (p ˂.01). The regression analysis results show that age and gender together explain 50.5% of the variance in CERS scores, while apelin and serotonin together explain 35.8% of the variance. When all four variables (age, gender, apelin, and serotonin) are included in the model, they explain 51.3% of the variance in CERS scores. Conclusion: Older age and female gender explained most of emotion regulations skills.Key points It was determined that the average salivary apelin and serotonin levels increased with increased age, and with increased age ERS also increased. More research is needed as this is the first time that the relationship between emotion regulation skills and serotonin and apelin levels has been examined.
AtıfScopus1OpenAlex1
İncele - MakaleAçık Erişim2024Polarization Insensitive and Thin Metamaterial Absorber Performed in High-Frequency 5G Bands
Arslan Madak, Seher Şeyma; Teber, Ahmet; Topkaya, Ramazan
A variety of fascinating applications, including 5G communication devices, high-speed data transfer, and large-scale Internet of Things (IoT), make life easier with 5G technology. Despite the 5G’s superior features, the percentage of electromagnetic (EM) waves in the environment execute a significant increase, unpleasantly. Broadband metamaterial absorbers are an appealing alternative to gather these unwanted signals. This study aims to numerically investigate a broadband metamaterial absorber (MMA) in the 5G high-frequency spectral range with the metasurface formed with coupled resistors. In addition, the 24.25-27.5GHz frequency range, one of the high-frequency 5G bands used by selected countries such as the European Union and China, was preferred. The minor aim of this study is that the usage of coupled elements as resistors may have the ability to increase the absorption bandwidth and magnitude. Comprehensive simulations were performed using the finite integration technique (FIT) utilized by the CST Microwave Studio program to investigate the absorber performance and other relevant parameters. The unit cell design is created metal-substrate-metal structures as asymmetric, single-layer, and easy to implement. The absorption responses are investigated according to the oblique incidence angle, polarization angle for TE &TM modes. The suggested MMA provided an absorbency response above 87.6% in the frequency range 24.20-27.30GHz under normal incidence. Moreover, to comprehend the physical mechanism on absorption, the top and bottom surfaces of the absorber's electric field and surface current distributions are assessed. The designed MMA resulting in relatively high performance and polarization insensitive is helpful for electromagnetic interference (EMI) shielding of 5G signals in the FR2/mmWave frequency regime.
AtıfScopus3TR Dizin1
İncele - MakaleAçık Erişim2024Scopus SJRQ1A Multi-response Nonlinear Programming Model with an Inscribed Design to Optimize Bioreduction Conditions of (S)-phenyl (pyridin-2-yl)methanol by Leuconostoc pseudomesenteroides N13
Özdemir, Akın; Şahin, Engin
Asymmetric bioreductions have the potential to synthesize chiral alcohols when catalyzed by biocatalysts. Nevertheless, the (S)-phenyl (pyridin-2-yl)methanol ((S)-2) analgesic synthesis poses significant challenges concerning unsatisfactory substrate amount and production method. Thus, this study proposes an inscribed design-focused multi-response nonlinear optimization model for the asymmetric reduction of the phenyl(pyridin-2-yl)methanone (1) with Leuconostoc pseudomesenteroides N13 biocatalyst. From the novel inscribed design-focused multi-response nonlinear optimization model, optimization conditions of the reaction, such as pH = 6, temperature = 29 °C, incubation time = 53 h, and agitation speed = 153 rpm, were found. Also, the reaction conversion was predicted to be 99%, and the product of the enantiomeric excess (ee) was 98.4% under the obtained optimization conditions. (S)-2 was obtained with 99% ee, 99% conversion, and 98% yield while performing a validation experiment using the determined optimized conditions. In addition, 1 with the amount of 11.9 g was converted entirely to (S)-2 (11.79 g, 98% isolated yield) on a high gram scale. Also, this study is noted as the first example of the gram-scale production of (S)-2 using an optimization strategy and biocatalyst. Further, the applicability of the inscribed design-focused optimization model in biocatalytic reactions has been demonstrated and provides an effective process for the analgesic synthesis of (S)-2, which is a green, cost-effective method of producing chiral aryl heteroaryl methanol.
AtıfScopus3WoS3OpenAlex3İncele - MakaleYalnız künye2024Scopus SJRQ1Ultrasound assisted choline chloride-based deep eutectic solvent extraction of bioactive compounds from salsify (Tragopogon buphthalmoides (DC.) boiss. Var. Latifolius Boiss.): A Box–Behnken design approach for optimization
Yilmaz, Özlem; Elbir Abca, Tuğba; Kamiloğlu, Aybike; Kutlu, Naciye
This study aimed to investigate the ultrasound-assisted extraction of bioactive compounds from salsify using deep eutectic solvents (DESs) with different molar ratios. For this reason, total phenolic (TPC), total flavonoid (TFC) compounds, and antioxidant activities (1,1-diphenyl-2-picrilhydrazyl radical scavenging activity (DPPH•), and ferric reducing antioxidant power (FRAP)) of extracts prepared with DES were investigated with an experimental design and optimization study conducted for this purpose. An extraction time of 40.15 min was determined as the optimal condition. Under these conditions, a molar ratio of 3:1 (acetic acid:choline chloride) and a water ratio of 42.17 % provided the highest phenolic/flavonoid compounds and antioxidant activity. Correlations between water ratio, molar ratio, and sonication extraction time were determined using principal component analysis (PCA). In conditions where TPC, FRAP, and DPPH• were high according to PCA, it can be concluded that the extraction time, water ratio, and molar ratio are at high levels; contrarily, TFC is at a low level. In conclusion, ultrasound-assisted extraction using DES proved effective for salsify. Therefore, choline chloride-based DESs, can be recommended as environmentally friendly green solvents and an alternative to organic solvents for the extraction of bioactive compounds from salsify.
AtıfScopus11WoS8OpenAlex10İncele - MakaleAçık Erişim2024Scopus SJRQ2Behind the Scenes: A Critical Perspective on GenAI and Open Educational Practices
Aksoy, Dilara Arzugül; Kursun, Engin
Artificial Intelligence (AI) is a rapidly evolving field that is influencing every aspect of life. Generative AI (GenAI) as a sub-branch of AI is used to create content in various formats such as text, images, video, and audio. This paper discusses the implications of GenAI for Open Educational Practices (OEP), highlighting the potential affordances and challenges. GenAI can address the challenges within the OEP by leveraging openness and ethical use. GenAI’s “generative” nature and human-like language capability can provide resources such as course material, activities, examples, questions, assessment, and learning outcomes in the context of OEP. With machine learning and deep learning infrastructure, it can support the discoverability and accessibility of open resources by increasing the metadata quality. GenAI can automatically score student assignments, answer their questions, and provide instant feedback to address the lack of interaction and feedback that arises due to the large number of students, especially in massive open online courses (MOOC). On the other hand, GenAI brings challenges such as data privacy and security, copyright, biased outputs, and the generation of false information. The conclusions emphasize the importance of a nuanced approach that considers not only the advantages but also the risks associated with adopting GenAI in the OEP world. Researching and developing how to apply these technologies to education is important to shape the future of education.
AtıfScopus27WoS18OpenAlex23İncele - MakaleYalnız künye2024Scopus SJRQ3Boundedness in a attraction-repulsion chemotaxis system with nonlinear production
Ayazoglu, Rabil
We study the quasilinear attraction-repulsion chemotaxis system of parabolic-elliptic type ut = ∆u−χ∇·(u∇υ)+ξ∇·(u∇ω) with nonlinear production 0 = ∆υ −βυ +αus, 0 = ∆ω −δω +γur, subject to the homogeneous Neumann boundary conditions in a bounded domain Ω ⊂ ℝN (N ≥ 3) with smooth boundary. It is proved that for every α, β, δ, γ, χ, ξ > 0 and s ≥ N2,r > N−2/N s, there exists ξ∗ > 0 such that if ξ > ξ∗ and any sufficiently regular initial datum u0(x) ≥ 0, then the model has a unique global classical solution (u, υ, ω), which is bounded in Ω × (0, ∞).
- MakaleYalnız künye2024Scopus SJRQ3Pollen morphology of Eremogone (Caryophyllaceae) in Türkiye
Tokuşoğlu, Kader Varlik; Armağan, Meti̇N; Bülbül, Ali̇ Savaş
The palynological characters of 17 taxa belonging to genus Eremogone Fenzl (Caryophyllaceae) from Türkiye were examined using light microscopy and scanning electron microscopy. Eremogone pollen in Türkiye is found to have an average size of 31.31 μm (26.62‒36.65 μm), pore sizes ranging from 6.52 to 9.24 μm, inter-pore distances ranging from 9.07 to 12.57 μm, pore numbers varying from 5 to 14 and 5‒30 nanoechini distributed in an area of 10 × 10 µm. The ornamentation was identified as nanoperforate, nanoechinate, or nanofaveolate surface elements in various combinations. Clustering analysis and Principal Component Analyses do not show clear groups, although more similar taxa were brought together through the analysis of pollen micromorphological data rather, the nanoechinate base width, nanoechinate length, and pore diameter length are the most valuable variables for separating the examined taxa.
- EditoryalYalnız künye2024Preface
Bayram, Nesrin Ecem; Kostic, Aleksandar Ž.; Gercek, Yusuf Can
- MakaleAçık Erişim2024Scopus SJRQ2TOTAL PHENOLICS, TANNIN CONTENTS, ANTIOXIDANT PROPERTIES, PROTEIN AND SENSORY ANALYSIS OF Pleurotus ostreatus, Pleurotus citrinopileatus AND Pleurotus djamor CULTIVATED ON DIFFERENT SAWDUSTS
Kılıç, Ceyhun; Gürgen, Ayşenur; Yıldız, Sibel; Can, Zehra; Değirmenci, Atiye
In mushroom cultivation, it is important to be aware of the impact of the growing substrate. This study investigated the cultivation of various oyster mushrooms, including Pleurotus ostreatus, Pleurotus citrinopileatus, and Pleurotus djamor, on different types of wood sawdust. Total phenolic content, condensed tannins, antioxidant activity by ferric reducing antioxidant power assay, protein and sensory evaluations were performed in cultivated oyster mushrooms. Wood sawdust of Fagus orientalis (oriental beech), Alnus glutinosa (alder), Castanea sativa (chestnut), and Juglans regia (walnut) were used as substrate for studied mushroom type, separately. Because champignon (Agaricus bisporus) was the most consumed mushroom, it was used as control sample. Methanolic extracts of dried mushrooms were used to measure bioactive characteristics. Pleurotus ostreatus samples cultivated in Alnus glutinosa (alder) sawdust substrate had the highest antioxidant activity. The lowest antioxidant activity values were found in Pleurotus djamor cultivated in Juglans regia (walnut) wood sawdust substrate. The highest protein content was measured in Agaricus bisporus as 13,84 %. The other highest protein concentration was found in Pleurotus ostreatus cultivated in Alnus glutinosa (alder) sawdust substrate, at 13,75 %. The lowest protein concentration belonged to Pleurotus citrinopileatus cultivated in Fagus orientalis (oriental beech) sawdust substrate as 9,86 %. While Agaricus bisporus and Pleurotus ostreatus had the highest overall appreciation score, Pleurotus citrinopileatus had the lowest. It has been observed that the substrate content has an important impact on chemical and sensory properties of the oyster mushrooms. This study provides knowledge on the chemical and sensory characteristics of three different Pleurotus mushroom species cultivated on different composts.
AtıfScopus5WoS5OpenAlex5İncele - BildiriAçık Erişim2024Tangential velocity and water vortex structure behaviour based on cylindrical-shaped basin's design parameters for gravitational vortex power plants
Teber, Ahmet; Iliev, T.; Stoyanov, I.; Mihaylov, G.; Kogias, P.; Fantidis, J.
The gravitational water vortex power plants (GWVPPs) have established in hydropower systems as a capable approach, generating micro-scale environment friendly electricity. In this system, energy is produced as a result of the interaction of water coming from an inlet canal with the turbine by creating a vortex in circular/conical-shaped structures. This interaction is based on an assumption that the water flow rate in a basin coincides with the tangential velocity on the turbine propeller. In this case, it is essential to investigate numerous geometric design parameters of the cylinder basin and their effects on vortex formation with the help of Computational Fluid Dynamics (CFD). Here, based on the CFD principles, the behaviour of various geometrical parameters on the vortex and tangential velocities in the basin are investigated separately with the help of Ansys Fluent, without using any turbine propeller. For a certain inlet flow velocity and head, different tunable geometric parameters for the gravitational water vortex plant with a cylindrical basin are inlet canal length, basin diameter, basin height and outlet diameter, respectively. The objective is to achieve an improved design configuration concerning factors such as tangential velocity, vortex arrangement, and the optimal placement of turbine propellers within this vortex.
AtıfScopus1İncele - MakaleYalnız künye2024Scopus SJRQ1The Role of Picturebooks in Supporting the Mathematical Knowledge of Preschool Teacher Candidates
Güven Akdeniz, Dilşad
Is children’s literature only beneficial to children? Or do the benefits of children’s literature also extend to the knowledge and mathematical skills of the teachers who employ it and reflect on it? This study seeks to investigate the role of picturebooks on the mathematical knowledge of preschool teacher candidates. For this purpose, in-depth examinations of how picturebooks can be used in teaching preschool mathematics and children’s literature. As well as the changes in the content knowledge of the teacher candidates, were done by conducting focus group interviews with teacher candidates. This is a qualitative case study consisting of focus group discussions in which high-level knowledge sharing and production can be achieved through interaction and associations. In the research, 11 picturebooks were discussed, and 8 teacher candidates participated in 6 focus group interviews lasting a total of 338 min throughout a 7 week period. The study’s findings have demonstrated that through children’s literature, teacher candidates’ misconceptions about measuring length can be revealed and eliminated without the need for another source, with discussions based on consciously and systematically selected picturebooks. Thus, it can be said that picturebooks act as a catalyst for the studies that aim to enhance the mathematical content knowledge of teacher candidates. The study has also observed that picturebooks can comprehensively address the fundamental concepts of length measurement.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ2Eugenol alleviates the negative effects of experimental periodontitis and regulates adipokine hormones in rats
Sevinç Gül, Sema Nur; Özkal Eminoğlu, Didem; Tekçe, Emre; Bayraktar, Bülent; Güven, Leyla; Dilsiz, Alparslan; Yıldırım, Serkan; Sait, Ahmet
A chronic microbial infection that is mediated by the host's immune system is the cause of periodontal disease. As the world's population grows, phytotherapy is a therapeutic strategy that makes use of a renewable resource that can provide less costly medicines. This study aimed to investigate the therapeutic effects of eugenol administration on periodontitis by examining the effects of eugenol at different doses biochemically, histopathologically, and radiologically in rats with experimental periodontitis. Thirty-two Sprague Dawley male rats were divided into four groups: 1. the healthy control group (CG), 2. The experimental periodontitis group (PG), 3. The experimental periodontitis+10 mg/kg eugenol group (EG10), and 4. the experimental periodontitis+20 mg/kg eugenol group (EG20). Alveolar bone loss was measured using micro-CT imaging. The TNF-α, IL-6, leptin, asprosin, and apelin levels were analyzed in the serum samples of rats. Histological and immunohistochemical analyses were performed. The data were analyzed statistically. The serum TNF-α, IL-6, leptin, asprosin, and apelin levels were found to be statistically significantly lower in the eugenol-applied groups (EG10 and EG20) than in the PG (p < 0.05). There was a statistically significant difference in the TNF-α, IL-6, leptin, asprosin, and apelin levels between the EG10 and EG20 (p < 0.05). In the measurements made using micro-CT imaging, alveolar bone loss was found to be at the lowest FR1 level, and in histopathological analysis, the least inflammation was observed in the EG20. It was concluded that the application of 20 mg/kg eugenol in rats with experimental periodontitis was a safe dose, was beneficial in alleviating bone loss, and had a positive effect on the healing process.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2024Olive Oil Production Forecasts for a Macro Perspective during 2024–2027
Kurtoğlu, Seval; Uzundumlu, Ahmet Semih; Gövez, Elif
Olive oil, which is part of the Mediterranean diet, is one of the most important foods for a healthy diet. The number of countries that produce these important foods has not increased significantly over the years. However, the number of exporting countries tripled in the same period. This study aimed to predict the countries that will lead olive oil production globally between 2024 and 2027 by using the production data from the period 1961–2023. The data were analyzed using the ARMA model in the statistical program SAS. According to the results for the 10-year period of 1961–1970, there were 25–26 olive-oil-producing countries in the world. Approximately 31.26% of olive oil production was in Italy, 28.32% in Spain, 13.14% in Greece, 7.80% in Turkey, and 5.74% in Portugal. According to the average production for the period 2024–2027, it is estimated that 34 and 35 countries will produce olive oil, with 29.93%, 9.08%, 9.06%, 9.00%, and 8.90% of the world’s production provided by Spain, Greece, Turkey, Morocco, and Italy, respectively. These five countries account for 65.96% of the world’s production level. The estimation results of this study found that there are many exporting countries other than the leading producer countries thus showing that the producer countries do not have a forceful marketing concept, and therefore intermediaries emerge. For this reason, producer countries such as Turkey, Tunisia, and Morocco, which are not very competent in marketing, will have more say in the market by using their resources more effectively and making more effective strategies with an improved production and marketing approach.
AtıfScopus27WoS28OpenAlex30İncele - MakaleAçık Erişim2024Scopus SJRQ2Antioxidant properties and aldose reductase inhibitory potency of Viscum album L. extracts: experimental and computational insights
Akyüz, Bilal; Şengül, Bülent
This study systematically investigates the antioxidant capacity and inhibitory impact of Viscum album L. plant extracts on the aldose reductase (AR) enzyme through a combined approach of in vitro and in silico methods. Various sections derived from distinct plant parts were examined, revealing potent inhibitory potential. Notably, the methanol extract sourced from the plant’s stem displayed remarkable efficacy with an IC50 value of 0.156 µM. Total phenolic content and antioxidant capacity analyses were conducted, highlighting variations across plant parts and solvent types. Qualitative and quantitative phenolic compound content in the extracts was elucidated by LC-MS/MS analysis, revealing higher levels of quinic acid, fumaric acid, and chlorogenic acid. Molecular docking studies further substantiated the inhibitory roles of key compounds like chlorogenic acid and fumaric acid, elucidating their interactions with specific amino acid residues within the AR enzyme’s active site and shedding light on the underlying mechanisms. Collectively, this study underscores Viscum album L. extracts as promising candidates for aldose reductase modulation. By merging experimental and computational techniques, the study presents a holistic understanding of natural compound interactions, potentially influencing drug development and herbal therapeutics.
AtıfScopus4WoS4OpenAlex4İncele - MakaleYalnız künye2024Scopus SJRQ3Exponential Convex Functions with Respect to s
Kadakal, Mahir
In this paper, we study the concept of exponential convex functions with respect to s and prove Hermite-Hadamard type inequalities for the newly introduced this class of functions. In addition, we get some refinements of the Hermite-Hadamard (HH) inequality for functions whose first derivative in absolute value, raised to a certain power which is greater than one, respectively at least one, is exponential convex with respect to s. Our results coincide with the results obtained previously in special cases.
AtıfScopus1WoS2İncele - MakaleAçık Erişim2024Scopus SJRQ1Synthesis of flaxseed gum/melanin-based scaffold: A novel approach for nano-encapsulation of doxorubicin with enhanced anticancer activity
Kumar, Deepak; Pal, Ravi Raj; Das, Neeladri; Roy, Partha; Saraf, Shubhini A.; Bayram, Sinan; Kundu, Patit P.
Doxorubicin is a powerful chemotherapy medicine that is frequently used to treat cancer, but because of its extremely destructive side effects on other healthy cells, its applications have been severely constrained. With the aim of using lower therapeutic doses of doxorubicin while maintaining the same anti-cancerous activity as those of higher doses, the present study designs nano-encapsulation of doxorubicin by acrylamide grafted melanin as core and acrylic acid grafted flax seed gum as shell (DOX@AAM-g-ML/AA-g-FSG-NPs) for studies in-vivo and in-vitro anticancer activity. For biological studies, the cytotoxicity of DOX@AAM-g-ML/AA-g-FSG-NPs was examined on a cancerous human cell line (HCT-15) and it was observed that DOX@AAM-g-ML/AA-g-FSG-NPs exhibited very high toxicity towards HCT-15. In-vivo investigation in colon cancer-inflicted rat model also showed that DOX@AAM-g-ML/AA-g-FSG-NPs showed better anticancer activity against cancerous cells as compared to free doxorubicin. The drug release behavior of DOX@GML-GFS-NPs was studied at several pH and maximum drug release (95 %) was recorded at pH -7.2, and kinetic data of drug release was follows the Higuchi (R2 = 0.9706) kinetic model. Our study is focussed on reducing the side effects of doxorubicin by its nano-encapsulation in acrylamide grafted melanin as core and acrylic acid grafted flax seed gum that will also enhance its efficiency.
AtıfScopus14WoS14OpenAlex15İncele - MakaleAçık Erişim2024Scopus SJRQ1Phytochemical profile, enzyme inhibition, antioxidant, and antibacterial activity of Rosa pimpinellifolia L.: A comprehensive study to investigate the bioactivity of different parts (whole fruit, pulp, and seed part) of the fruit
Findik, Bahar Tuba; Yildiz, Hilal; Akdeniz, Mehmet; Yener, Ismail; Yilmaz, Mustafa Abdullah; Cakir, Ozlem; Ertas, Abdulselam
The pharmaceutical and nutraceutical potentials of whole fruit, pulp and seeds of Rosa pimpinellifolia L. were evaluated. Forty-two phenolic compounds and two triterpenoids were identified in extracts by LC-MS/MS and GC–MS, respectively. The most prominent compounds were ellagic acid, catechin, epicatechin, tannic acid, quercetin, oleanolic acid, and ursolic acid. The highest enzyme inhibitory activities of the extracts (94.83%) were obtained against angiotensin-converting enzyme and were almost equal to those of the commercial standard (lisinopril, 98.99%). Whole fruit and pulp extracts (IC50:2.47 and 1.52 μg DW/mL) exhibited higher antioxidant capacity than the standards (α-tocopherol, IC50:9.89 μg DW/mL). The highest antibacterial activity was obtained against Bacillus cereus (MIC: 256 μg/mL) for the whole fruit extract. Correlation analyses were conducted to find the correlation between individual phenolics and enzyme inhibitory activities. The results showed the remarkable future of not only the edible part but also the seeds of black rose hips in phytochemical and functional aspects.
AtıfScopus15WoS14OpenAlex17İncele - MakaleAçık Erişim2024Scopus SJRQ1Removal kinetics of vinyl acetate under aerobic and anoxic conditions in a batch bioreactor
Yalçın Çelik, Beste; Nuhoğlu, Alper; Kul, Sinan; İrdemez, Şahset
Vinyl acetate is a volatile organic compound widely used in the chemical industry, and there is a need for effective and economic removal of this volatile organic compound from wastewater and waste gases in chemical industries. This study aims to determine the biological treatability of vinyl acetate both under aerobic and anoxic conditions using mixed cultures obtained from a wastewater treatment plant. Considering the previous studies in the literature, testing the biodegradability of vinyl acetate under both aerobic and anoxic conditions, together with evaluating the effect of other mechanisms, such as adsorption and volatilization, on the removal of vinyl acetate, can be regarded as the prominent part of this study. Wastewater containing artificially prepared vinyl acetate was treated in a batch bioreactor, and performance and kinetic constants were investigated. Aerobic treatment under batch conditions conformed to the Haldane biokinetic equation, and the biokinetic constants of μmax, Ks, and Ki were calculated as 0.66 h−1, 19.67 mg L−1 and 50.56 mg L−1, respectively. Anoxic treatment under batch conditions conformed to the Monod biokinetic equation, and the biokinetic constants of μmax and Ks were calculated as 0.31 h−1 and 33.88 mg L−1, respectively. Experiments revealed that vinyl acetate was not volatile, and its adsorption and biological treatment performances were 28% and 72%, respectively. The mixed culture had a very high performance for removing vinyl acetate under batch operating conditions. The primary mechanism of vinyl acetate removal was found to be biological treatment.
AtıfOpenAlex1İncele