Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Dertli, Enes(47)
- Pat, Suat(29)
- Özen, Soner(29)
- Şenay, Volkan(24)
- Korkmaz, Şadan(23)
- Esmer, Yusuf(21)
- Şahin, Engin(21)
- Korkmaz, Özge(20)
- Cuce, Erdem(19)
- Öner, Erdal(18)
- Öztürk, Mesut(18)
- Artar, Musa(17)
- Yilmaz, Mustafa Tahsin(17)
- İspirli, Hümeyra(16)
- Ecem Bayram, Nesrin(15)
- Kaya, Yunus(15)
- Cinar, Mehmet(13)
- Cuce, Pinar Mert(12)
- Kamiloğlu, Aybike(12)
- Kutlu, Naciye(12)
- Mercan, Emin(12)
- Birinci, Ahmet(11)
- Bulut, Mehmet(11)
- Yaylacı, Murat(11)
- Bayram, Ozkan(10)
- Can, Zehra(10)
- Doğan, Zeki(10)
- Kahya, Cem(10)
- Karaali, Rabi(10)
- Pabuçcu, Hakan(10)
- Tosun, Figen Çam(10)
- Özdemir, Akın(10)
- Ayazoglu, Rabil(9)
- Battal, Fetullah(9)
- Bayram, Nesrin Ecem(9)
- Büte, Mustafa(9)
- Ertugrul, Mehmet(9)
- Kadakal, Mahir(9)
- Kaplan, Abdullah(9)
- Sarikaya, İsmail(9)
Yayınlar
- MakaleYalnız künye2026The First Report Card on Physical Activity for Children and Adolescents in Türkiye
Yarımkaya, E; Oğur, YG; Aydemir, U; Türkmen, M
- MakaleYayıncıda açık erişim2026Scopus SJRQ1The indirect association between psychological well-being and professional commitment through teacher self-efficacy among Turkish language teachers
Şahin, TG; Banaz, E; Özbilen, U
- MakaleYalnız künye2026Chrysin as a multi-target regulator of tramadol-induced testicular damage: Integration of inflammation, mitochondrial dynamics, and germ cell survival pathways
Erol, İ; Özdemir, S; Küçükler, S; Özkaraca, M; Akarsu, SA; Şimşek, H; Kızıl, HE; Mutlu, H; Kandemir, FM
- MakaleYalnız künye2026Çilek Tarlalarındaki Ortam Sıcaklığının Bal Arıları ve Yerli Tozlayıcı Arıların Aktiviteleri Üzerindeki Etkisi
Erdogan, Ummugulsum; Erdoğan, Yaşar
Küresel iklim değişikliğine bağlı artan sıcaklıklar, arı aktivite desenlerini ve bitkilerin tozlaşma verimliliğini önemli ölçüde etkilemektedir. Bu çalışmada, ortam sıcaklığının çilek (Fragaria × ananassa) tarlalarındaki bal arıları (Apis mellifera) ve yabani polinatör arı türlerinin aktivitesi üzerindeki etkisi araştırılmıştır. Gözlemler, 12-22°C arasındaki sıcaklık aralıklarında farklı arı türlerinin çiçekleri ziyaret sıklıkları kaydedilerek yapılmıştır. Bulgular, A. mellifera'nın tüm sıcaklık aralıklarında gözlendiğini ve aktivite seviyesinin sıcaklık arttıkça önemli ölçüde arttığını göstermektedir. Yerli türler arasında Lasioglossum spp. ve Halictus quadricinctus daha dar sıcaklık aralıklarında aktifken, Eristalis tenax daha yüksek sıcaklıklarda en yüksek aktivitesini göstermiştir. Genel olarak, bal arıları geniş bir termal toleransa sahipken, yerli arı türleri daha sınırlı sıcaklık aralıklarında faaliyet göstermektedir. Bu sonuçlar, yerli arı topluluklarının iklim değişikliğinin ilerlemesiyle tozlaşma hizmetlerinin azalması riskiyle karşı karşıya olduğunu ve bu türlerin korunmasının tarımsal sürdürülebilirlik için önemli olduğunu göstermektedir.
- MakaleYalnız künye2026Evaluation of Phenotypic Traits and Essential Oil Content in Wild-Grown Achillea biebersteinii Populations in Northeastern Türkiye
Coban, Furkan; Gül, Volkan; Çakır, Ahmet
Achillea biebersteinii Afan., a medicinal and aromatic plant widely distributed in Türkiye, is valued for its essential oil content and bioactive compounds. This study aimed to investigate the phenotypic variation, yield performance, and essential oil content of A. biebersteinii populations collected from ten different locations in northeastern Türkiye. A total of six morphological and agronomic traits plant height (PH), inflorescence diameter (ID), stem diameter (SD), number of flowering branches (NFB), dry herbage yield (DHY), and dry flower yield (DFY) alongside essential oil content (EO), were evaluated. ANOVA results revealed statistically significant differences among locations for PH, DHY, and NFB, indicating strong environmental or genetic influences. In contrast, EO content showed no significant variation across locations, suggesting greater genetic stability. Correlation analysis indicated a strong positive association between NFB and DHY, while EO content was negatively correlated with PH and SD. Principal Component Analysis further clarified trait associations and revealed distinct groupings among locations, with L9 and L10 showing superior yield performance and L3 standing out for its high EO content. These findings highlight the substantial phenotypic and chemotypic diversity of A. biebersteinii in northeastern Türkiye and underscore the importance of location specific selection in breeding and conservation programs. The identification of high-yielding and high-quality populations provides a valuable resource for sustainable utilization of this species in medicinal and aromatic plant sectors.
- MakaleYalnız künye20267. Sınıf Canlılarda Üreme, Büyüme ve Gelişme Ünitesinin Öğretiminde Öğrenme Amaçlı Yazma Aktivitelerinden Mektubun Etkisi
Öztürk, Bilge; Küçükgül, Mustafa
Bu araştırmanın amacı, ortaokul 7. sınıf fen bilimleri dersinde yer alan “Üreme, Büyüme ve Gelişme” ünitesinin öğretiminde Öğrenme Amaçlı Yazma (ÖAY) aktivitelerinin öğrenme üzerindeki etkisini ve bu etkinliklerle yürütülen ders sürecine ilişkin öğrenci görüşlerini incelemektir. Araştırmada karma araştırma yöntemlerinden müdahale deseni kullanılmıştır. Araştırmanın çalışma grubunu 2023-2024 eğitim-öğretim yılı bahar döneminde Bayburt Merkezde yer alan bir ortaokulun 7. sınıfında öğrenim gören 56 öğrenci oluşturmaktadır. Araştırmada veri toplama aracı olarak; Üreme, Büyüme ve Gelişme Başarı Testi (ÜBGBT) ve yarı yapılandırılmış Görüşme Formu (GF) kullanılmıştır. ÜBGBT’nin ön testinin analizinde bağımsız örneklem t testi, son testinin analizinde Mann-Whitney U Testi kullanılmıştır. Nitel verilerin analizinde ise içerik analizi yönteminden yararlanılmıştır. ÜBGBT' den elde edilen verilerin analizi sonucunda ÖAY aktivitelerinden mektubun, 7. sınıf öğrencilerinin Üreme, Büyüme ve Gelişme ünitesindeki akademik başarılarını artırdığı tespit edilmiştir. Ayrıca GF verilerinin analizi, öğrencilerin ÖAY aktiviteleri hakkında olumlu düşünceler geliştirdiğini göstermektedir.
- MakaleYalnız künye2026Scientific Relations of the Ilkhanate State (Examples of China, India, and Egypt)
Dayı, Özkan
Despite the negative effects of the Mongol invasion in the thirteenth century, many countries, geographies, nations, and cultures found the opportunity to come together. This situation also led to the interaction of scientific and cultural elements, which had been limited politically and militarily, with each other. This period of interaction in scientific fields continued during the Ilkhanate, which was established in the Near East as a branch Mongol state after 1256. In addition to their commercial and political relations, the Ilkhanates maintained scientific exchanges with China, India, and Egypt. During the Mongol era, scientific relations were initially established by scholars and mueddibs who sought refuge in these regions to escape the Mongol invasion and received protection. With the arrival of Ilkhan Hülegü in the Near East, the Ilkhanids, also known as the Iranian Mongols, continued their scientific relations by establishing educational institutions, scientific research centers, and patronizing scholars. Scientific relations with the Yuan dynasty in China, the Delhi Turkic Sultanate in India, and the Mamluks in Egypt became a state policy consistently pursued by the Ilkhanate in a scientific sense during this period. In this study, we aim to convey the Ilkhanate's scientific relations with the geographies of China, India, and Egypt.
- MakaleYalnız künye2026Examining the Attitudes of Physical Education Teacher Candidates Toward the Teaching of Students with Special Needs
Aydemir, Uğur
This study aims to investigate the attitudes of physical education teacher candidates toward teaching students with special needs. The study, designed as a descriptive survey, involved 284 teacher candidates studying in physical education teacher training departments at universities. Data were collected using the “Attitudes of Physical Education Teachers Toward the Education of Individuals with Disabilities-III” scale. The Mann-Whitney U-test was used for data analysis. The findings obtained as a result of the analyses revealed that the attitudes of physical education teacher candidates toward the teaching students with special needs were negative. It was determined that the attitude scores of physical education teacher candidates toward the teaching students with attention deficit and hyperactivity disorder were lower than their attitude scores toward other special needs groups. In addition, it was observed that teacher candidates who had individuals with special needs in their families, who had previously taught individuals with special needs, and who had taken courses on individuals with special needs during their undergraduate education had higher attitude scores, while there was no significant difference in the attitude scores of physical education teacher candidates according to gender. In light of these findings, it is recommended that application-oriented course content be created during undergraduate education and that activities be organized in which physical education teacher candidates participate together with students with special needs, in order to contribute to the development of positive attitudes toward the teaching students with special needs among physical education teacher candidates.
- MakaleYalnız künye2026Scopus SJRQ4The scientific structure of the field of rural development and social entrepreneurship: A bibliometric analysis based on web of science data
Battal, Fetullah; Öz, Halil Hakdan; Yılmaz, Şeymanur
Purpose: This study was conducted to reveal the scientific trends, thematic structures, and intellectual orientations in the literature on rural development and social entrepreneurship. The study aims to provide a comprehensive overview of current research trends by identifying the points of intersection between these two fields.Design/Methodology/Approach: A bibliometric analysis technique was used in the research. Data was obtained from the Web of Science (WoS) database and focused on the period between 2006 and 2025. Only research articles published in the fields of Business, Management, and Economics were included in the analysis. A total of 407 articles were examined, and the annual growth rate was calculated as 20.58%.Results: The results show that social entrepreneurship is playing an increasingly strategic role in rural development processes and that publications in the literature are concentrated around the themes of social capital, innovation, women's entrepreneurship, and sustainability. Aleksandras Stulginskis University, South China Agricultural University, and the University of Nigeria stand out among the most productive institutions. Bradford Law findings reveal that publications are concentrated around a small number of core journals. Consequently, the role of social entrepreneurship in rural development is related not only to economic growth but also to social welfare and sustainability dimensions.Originalit/Value: This study is one of the few bibliometric analyses that jointly examine social entrepreneurship and rural development. Based on Web of Science data, it reveals the research networks, thematic trends, and future research opportunities in the field, making a significant contribution to the literature.
- MakaleYalnız künye2026Akademik Akıl ile İnanan Kalbin Sentezi: İlahiyat Öğrencileri İçin Kur’an ile İlişki Ölçeği’nin (Kiö) Geliştirilmesi
Süheyb, Okur
İlahiyat eğitimi, doğası gereği öğrencileri “akademik aklın” eleştirel disiplini ile “inanan kalbin” manevi teslimiyeti arasında karmaşık bir sentez kurmaya zorlamaktadır. Ancak mevcut literatürdeki ölçme araçları, öğrencilerin Kur'an-ı Kerim ile kurdukları bu çok katmanlı ilişkiyi genellikle “okuma sıklığı” gibi davranışsal boyutta ele almakta, varoluşsal ve entelektüel bütünleşmeyi ölçmekte yetersiz kalmaktadır. Bu çalışma, ilahiyat fakültesi öğrencilerinin Kur'an-ı Kerim ile kurdukları ilişkinin doğasını; manevi yönelim, akademik ilgi ve bu iki alanın bütünleşmesi ekseninde değerlendirebilecek geçerli ve güvenilir bir ölçme aracı geliştirmek amacıyla yürütülmüştür. Metodolojik araştırma desenine sahip çalışmanın verileri, 2025-2026 eğitim-öğretim yılı güz döneminde Bayburt Üniversitesi İlahiyat Fakültesinde öğrenim gören lisans öğrencilerinden iki aşamalı olarak toplanmıştır. Ölçek geliştirme sürecinde, 161 öğrenciden elde edilen verilerle açımlayıcı faktör analizi (AFA), 288 öğrenciden elde edilen verilerle ise doğrulayıcı faktör analizi (DFA) gerçekleştirilmiştir. Analizler sonucunda, toplam varyansın %63,214’ünü açıklayan, 13 madde ve üç alt boyuttan (Manevi Yönelim, Bütünleşme, Akademik İlgi) oluşan psikometrik açıdan güçlü bir yapı elde edilmiştir. Doğrulayıcı faktör analizi sonuçları, modelin mükemmel uyum iyiliği değerlerine sahip olduğunu göstermiştir (χ²/sd= 2.471, RMSEA=.072, CFI=.942). Ölçeğin iç tutarlılık katsayısı (Cronbach Alpha) ise .884 olarak hesaplanmıştır. Sonuç olarak literatüre kazandırılan “Kur'an ile İlişki Ölçeği (KİÖ)”, öğrencilerin Kur’an’ı Kerim ile kurdukları ilişkiyi sadece teknik bir okuma eylemi olarak değil, akademik merak ve manevi huşunun iç içe geçtiği bütüncül bir tecrübe olarak ölçme imkânı sunmaktadır.
- MakaleYayıncıda açık erişim2026Yİ-DARBOUX SLANT HELICES ON SURFACES
Tosun, Ceyda; Kocayigit, Huseyin; Aydin, Tuba agirman
In this study, a new class of surface curves, namely Yi-Darboux slant helices, is investigated. The conditions under which a surface curve is a iY-Darboux slant helix with respect to the Osculating Darboux (OD), Normal Darboux (ND), and Rectifying Darboux (RD) frames are established, and several characterizations are obtained. In particular, necessary and sufficient conditions are derived in terms of the curvature functions associated with these frames. Furthermore, relationships between iY-Darboux slant helices and classical helices and slant helices are established for special surface curves, including geodesics, asymptotic curves, and lines of curvature. Concrete examples on conical and cylindrical surfaces are also presented to illustrate the theoretical results.
- MakaleYalnız künye2026Scopus SJRQ1Comparison of Eating Behaviours, Anthropometric Measures, and Malnutrition Risk in Children With Autism Spectrum Disorder and Other Developmental Disabilities
Esgin, Ozge; Ari-Arat, Ceren; Yilmaz, Gulsum; Hamitoglu, Aysun
Purpose This study examined differences in eating behaviours, anthropometric indicators, and malnutrition risk among children aged 5-16 years with autism spectrum disorder (ASD) and other developmental disabilities (DD), including Down syndrome, developmental language disorder, and attention-deficit/hyperactivity disorder (ADHD). Methods This study was carried out using a cross-sectional design and included 220 children attending special education and rehabilitation centres: 97 autistic children (girls: 26, boys: 71) and 123 children with other developmental disabilities (DD; girls: 44, boys: 79). The DD group comprised children with Down syndrome (n = 52, 42.3%), developmental language disorder (n = 58, 47.2%), and attention-deficit/hyperactivity disorder (ADHD; n = 13, 10.6%). Results Autistic children differed from children with other developmental disabilities in both growth patterns and eating behaviour profiles. Height-for-age z-scores were higher in children with ASD than in those with Down syndrome (DS) and developmental language disorder (DLD) (p=.01). Autistic children showed higher Food Fussiness scores than children with DS (p<.05). Associations between eating behaviours and BMI-for-age varied according to diagnostic group (all interaction p<.05). In other developmental disability groups, eating behaviours also varied according to BMI-for-age categories and malnutrition risk (p<.05). Among autistic children, malnutrition risk was associated with higher Food Responsiveness and Slowness in Eating scores (p<.05). Conclusion This study showed that eating behaviours, anthropometric measurements, and malnutrition risk vary among children with ASD and diagnostically distinct developmental disability subgroups, underscoring the importance of individualised, diagnosis-informed nutritional assessment and monitoring.
- MakaleYayıncıda açık erişim2026Asymmetric Nexus Between Gold and Bitcoin: New Evidence from Hidden Cointegration Approach
Yildiz, Umit
The main objective of this study is to investigate the symmetric and asymmetric linkages between gold, a traditional investment instrument, and Bitcoin, often referred to as the digital gold of cryptocurrencies, and to determine their direction and magnitude. Forthis purpose, the study examines cointegration relationships amongthe variables using weekly data from January 2, 2022, to April 5, 2026. According to the Engle & Granger (1987) cointegration test, there is no long-term relationship between the variables. However, the Granger &Yoon (2002) hidden cointegration test determined hidden cointegration relationships from the gold's positive components to the Bitcoin's positive components and from the Bitcoin's positive components to the gold's negative components. Subsequently, longterm coefficients are estimated using FMOLS, DOLS, and CCR estimators. The results show that a 1% increase in gold's positive shocks leads to approximately a 0.92%-0.95% decrease in Bitcoin's positive shocks. A 1% increase in Bitcoin's positive shocks results in approximately a 0.08%-0.10% increase in gold's negative shocks. The estimation results show that increases in gold prices significantly constrain the rise in Bitcoin prices, but the impact of Bitcoin price increases on gold price decreases remains limited. Finally, the findings demonstrate that gold's market-making capacity as a traditional investment vehicle is stronger than that of modern financial investment vehicles.
- MakaleYalnız künye2026Scopus SJRQ2Analyzing IPO Performance on Borsa Istanbul: A Hybrid Econometric and Machine Learning Framework (2013-2025)
Ayberkin, Doruk
This study examines the determinants of the performance of initial public offerings (IPOs) conducted by 237 firms across 38 sectors on the Istanbul Stock Exchange between 2013 and 2025, using a hybrid analytical framework. To analyze the impact of sector characteristics, firm-level financial indicators, supply structure, and market timing on the returns of USD-denominated IPOs, this study combines heteroskedasticity-resistant ordinary least squares (OLS) regression with tree-based ensemble machine learning algorithms (random forest, XGBoost) and benchmark models (support vector regression, artificial neural network). The distributional characteristics of returns from IPOs highlight the use of nonlinear modelling techniques characterized by high positive skewness (5.12) and excess kurtosis (45.24). Our findings reveal significant sectoral heterogeneity. According to the findings, the Financial Services and Fisheries sectors showed statistically significant superior performance, while the Metal Mining, Insurance, and Construction sectors underperformed. Transportation and Storage exhibited the highest point estimate but did not reach conventional significance levels. The XGBoost machine learning model, with an R 2 of 0.869 and a mean absolute error (MAE) of 17.87, achieved superior single-split prediction accuracy compared to the OLS method, which yielded an R 2 of 0.220. However, cross-validation analyses indicated that all models exhibited limited out-of-sample generalizability (best CV R 2 = 0.04). The Diebold-Mariano test, conducted to compare prediction performance, confirmed that the artificial neural network (ANN) model provided a statistically significant improvement over the OLS method (DM = 2.121, p = 0.034). The SHAP value analysis used in the models reveals how each feature affects the final predictions, the relative importance of each feature, and the model's dependence on feature interactions. It identifies the IPO price (USD), the USD/TRY exchange rate, and the size of the supply as the most effective estimators with economically significant nonlinear interactions. The study aims to demonstrate the comparative advantages and limitations of ensemble learning under abnormal financial data conditions by presenting detailed sectoral evidence across 38 sectors. In this way, it aims to contribute to the IPO literature in emerging market economies by offering viable policy recommendations for investors, issuers, and regulators in Turkish capital markets.
- MakaleYalnız künye2026Scopus SJRQ3Adult's food label awareness: scale development and validation
Açikgöz, Inci; Köktürk, Seda Nur; Yardimci, Hulya
PurposeThis study aimed to develop and validate the Food Label Awareness Scale (FLAS) to comprehensively assess adults' food label reading habits and expectations.Design/methodology/approachThe FLAS was developed based on a literature review and expert input. Initial item generation was followed by expert evaluations for content and face validity. Data were collected through structured face-to-face interviews using the preliminary version of the FLAS and a sociodemographic questionnaire. A total of 300 adults aged 20-65 years participated. Food label awareness was assessed based on the three subdimensions: (1) product packaging and ingredients, (2) nutrition and health and (3) product brand. In addition, participants' age, gender and education level were recorded. Cronbach's alpha assessed internal consistency. Reliability was supported by comparing the highest and lowest 27% of total scores. Associations between demographics and subdimension scores were tested using appropriate statistical methods.FindingsThe finalized 18-item FLAS demonstrated a three-factor structure with acceptable model fit and internal consistency. Older adults had higher awareness of packaging and ingredients. Lower education was associated with greater reliance on product brand.Research limitations/implicationsA primary limitation is the geographically restricted sample, which may limit the generalizability of the findings.Originality/valueThis study is original in developing a valid and reliable scale specifically measuring adults' awareness of food label reading - an area less explored in the literature, which mostly emphasizes general nutrition knowledge or label reading frequency.
AtıfWoS1OpenAlex1
İncele - MakaleYalnız künye2026Scopus SJRQ2Health Belief Model-Based Education to Improve Water Intake and Hydration in Older Adults: A Randomized Controlled Trial
Çimen, Arzu; Akpinar, Reva Balci
PURPOSE: The current randomized controlled trial examined the effects of Health Belief Model (HBM)-based education on daily water intake, hydration biomarkers, thirst discomfort, and dry eye complaints in older adults. METHOD: Eighty community-dwelling older adults aged >= 65 years with insufficient daily water intake (<1 L/day) were screened and randomly assigned to intervention (n = 40) and control (n = 40) groups. Eligibility was determined using predefined inclusion criteria and baseline assessments. The intervention included individualized HBM-based education supported by a booklet and intake log. Data were collected using a descriptive form, Thirst Discomfort Scale, Ocular Surface Disease Index, and refractometer-based measurements of urine specific gravity and refractive index. RESULTS: Postintervention mean daily water intake significantly increased in the intervention group (mean = 749.8 [SD = 176] mL vs. 572.9 [SD = 159.3] mL; p < .001). Thirst discomfort scores decreased, and between-group differences were found in urine specific gravity and refractive index (p < .001). Although Ocular Surface Disease Index scores improved (p = .002), the clinical impact was limited. CONCLUSION: HBM-based education increased water intake and reduced thirst discomfort, supporting community-based geriatric nursing practice. Future studies should examine long-term effects and support integration of theory-based hydration education into nursing training and clinical practice.
- MakaleYalnız künye2026Scopus SJRQ2The Mediating Role of Parental Self-Efficacy in the Relationship Between Parenting Stress and Coparenting
Turhan, Fatma Seher; Yayla, Ibrahim Erdogan; Sahranç, Umit; Makas, Samet; Yildirim, Murat
Parenting stress is a critical factor influencing family dynamics, often undermining the quality of coparenting. Exploring the mechanisms through which parenting stress impacts coparenting and the potential mediating role of parental self-efficacy is essential for developing effective family-based interventions. This study aims to examine the mediating role of parental self-efficacy in the relationship between parenting stress and coparenting. The sample consisted of 240 parents (79.6% female) aged 25-58 (M = 36.5). Participants completed the Parenting Stress scale, the Berkeley Parenting Self-Efficacy Scale, and the Coparenting Scale. Parenting stress showed a significant negative association with both coparenting quality and parenting self-efficacy. Furthermore, parenting self-efficacy was found to mediate the association between parenting stress and coparenting. These results highlight the important role of parents' self-efficacy in influencing how stress influences coparenting dynamics. Strengthening parents' confidence in their parenting abilities may help buffer the harmful effects of stress and foster more cooperative, supportive coparenting practices.
- MakaleYalnız künye2026Scopus SJRQ1Morin counteracts KBrO3-induced hepatotoxicity by reprogramming the HOTAIR/MEG3-miR-125b-5p/miR-214-5p axis and suppressing STAT1-associated RIPK3/MLKL necroptotic signaling
Özer, Muhammed Rasit; Özdemir, Selcuk; Küçükler, Sefa; Özkaraca, Mustafa; Kizil, Hamit Emre; Akaras, Nurhan; Mutlu, Huseyin; Kandemir, Fatih Mehmet
Potassium bromate (KBrO3; PB), an oxidative contaminant in ozonated water and bakery products, induces multi-mechanistic hepatotoxicity. Its epigenetic, necroptotic, and metabolic injury dimensions remain poorly characterized. Morin (MOR), a dietary flavonoid with established antioxidant and anti-inflammatory properties, has not previously been evaluated against PB-induced subacute hepatotoxicity. To characterize MOR's hepatoprotective mechanisms against PB-induced liver injury, focusing on the HOTAIR/MEG3-miRNA epigenetic axis, STAT1-associated RIPK3/MLKL necroptotic signaling, and Glut2/HPGD-AKT/mTOR metabolic signaling. Male Sprague-Dawley rats (n = 28) were assigned to Control, MOR (100 mg/kg), PB (62 mg/kg), and PB + MOR groups for 14 days. Outcomes included hepatobiliary biochemistry, oxidative stress markers, inflammatory mediators (ELISA), lncRNA/miRNA/mRNA profiling (RT-qPCR), immunohistochemistry (RIPK3, MLKL), double immunofluorescence (Glut2/AKT1; HPGD/mTOR), histopathology, and PCA. PB produced marked redox imbalance (up arrow MDA; down arrow SOD, CAT, GPx), NF-kappa B/NLRP3-associated inflammatory mediator elevation, epigenetic disruption (up arrow HOTAIR, down arrow MEG3; up arrow miR-125b-5p/down arrow BCL2L2; down arrow miR-214-5p/up arrow SMAD4), upregulation of STAT1-associated necroptosis-related transcripts and proteins (up arrow RIPK1/RIPK3/MLKL), and metabolic dysfunction (down arrow Glut2, down arrow HPGD; up arrow AKT1/mTOR). MOR restored redox balance, suppressed inflammation, and reprogrammed the miRNA axis while normalizing MLKL (transcript and immunohistochemistry) and AKT1 and partially attenuating RIPK3, mTOR, and STAT1. MOR confers multi-targeted hepatoprotection by restoring redox and metabolic homeostasis, attenuating NF-kappa B/NLRP3-associated inflammation, reprogramming HOTAIR/MEG3-miRNA epigenetics, and attenuating STAT1-associated RIPK3/MLKL signaling, supporting its potential as a dietary hepatoprotective candidate. PB is associated with engagement of the hepatic STAT1/RIPK3/MLKL axis and disrupts the HOTAIR/MEG3-miRNA network-both previously undocumented for this toxicant. MOR partially restores miR-214-5p/miR-466 expression while suppressing their downstream effector SMAD4, consistent with attenuation of pro-fibrotic signaling. Future work should employ multi-dose designs, in vitro mechanistic dissection, sex-stratified analyses, and clinical pharmacokinetic profiling to advance MOR toward translational application.
- MakaleYalnız künye2026Scopus SJRQ2Comparative investigation of composite-metal lap joints with mono-adhesive and thermoplastic-reinforced mixed adhesive at elevated temperatures
Erbayrak, Engin; Eker, Beril; Colak, Murat
This study primarily examines the strength of a single lap joint having a mixed adhesive overlap consisting of a single adhesive and its thermoplastic reinforced state under varying temperatures. In the single lap joint, Titanium-Boron reinforced A356 aluminum was employed as the metal adherend, while plain woven glass fiber-reinforced epoxy (GFRE) was employed as the composite adherend. In the application of the mixed adhesive overlap, the brittle adhesives were employed in the middle section of the lap joint, while the reinforcement of the thermoplastics was employed on the adhesives at both sides of the lap joint. The single lap joints were subjected to tensile tests at 1 mm/min loading rates under room temperature and 120 °C, which is the melting point of the copolyester. In the numerical analysis, the cohesive zone model was applied in order to define the adhesives; however, elastic isotropic and orthotropic material behaviors were employed for the metal and composite adherends, respectively. Eventually, it is determined that the strength of a mixed adhesive lap joint consisting of a single adhesive and its thermoplastic reinforced state is better than a lap joint made with the mono-adhesive alone. Although literature suggests that mixed adhesive overlaps can be formed using at least two different adhesives (one ductile and one brittle), this study demonstrated that a mixed adhesive zone can be created using a single adhesive and thermoplastic reinforcement.
- MakaleYalnız künye2026Scopus SJRQ2Sorting chiral active Brownian particles with radially modulated optical fields
Yücel, Harun
This study presents a numerical investigation of sorting chiral active Brownian particles using radially modulated optical fields. How these factors affect particle trajectories and spatial distributions is examined by systematically varying particle parameters such as self-propulsion speed, angular velocity, and optical fringe modulation. It is found that the average orbit radius of the particle trajectory strongly depends on the ratio of the self-propulsion speed to the average velocity induced by the moving fringe pattern. In particular, the average orbit radius converges to the theoretical orbit radius defined by the ratio of the self-propulsion speed to the angular velocity in the regime where the self-propulsion speed is greater than the fringe-induced velocity. In mixtures of particles with differing chirality, the dynamic response to circular fringe patterns enables effective classification based on motility. These findings suggest that structured light fields can be used to manipulate and selectively sort chiral active particles, which have potential applications in optical micromanipulation and active matter research.
