Yazarlar
- Dertli, Enes(10)
- Ertugrul, Mehmet(8)
- Kaya, Yunus(8)
- İspirli, Hümeyra(6)
- Şahin, Engin(6)
- Kutlu, Naciye(5)
- Ramahi, Omar M.(5)
- Bayram, Sinan(4)
- Gerçek, Yusuf Can(4)
- Hasar, Ugur C.(4)
- Hasar, Ugur Cem(4)
- Kul, Sinan(4)
- Sefali, Abdurrahman(4)
- Çelik, Saffet(4)
- Ayazoglu, Rabil(3)
- Dirican, Ebubekir(3)
- Ecem Bayram, Nesrin(3)
- Ekmekyapar Torun, Fatma(3)
- Gökçe, H.S.(3)
- Izginli, Mucahit(3)
- Ozturk, Gokhan(3)
- Ozturk, Hamdullah(3)
- Taylan, Osman(3)
- Tozlu, Alperen(3)
- Yilmaz, Mustafa Tahsin(3)
- Akkoyunlu, Ebubekir(2)
- Arslaner, Ayla(2)
- Artar, Musa(2)
- Barroso, Joaquim J.(2)
- Barroso, Joaquim Jose(2)
- Bülbül, Ali Savaş(2)
- Cabuk, Refik(2)
- Can, Zehra(2)
- Carbas, Serdar(2)
- Cuce, Erdem(2)
- Erten, Tayyibe(2)
- Eryılmaz Türkkan, Gökçen(2)
- Guclu, Tamer(2)
- Guleryuz, Didem(2)
- Hırca, Tuğçe(2)
Yayınlar
- MakaleYalnız künye2022High-Intensity Interval Training with Cycling and Calisthenics: Effects on Aerobic Endurance, Critical Power, Sprint and Maximal Strength Performance in Sedentary Males
Kul, Murat; Turkmen, Mutlu; Yildirim, Umit; Ceylan, Ramazan; Sipal, Onur; Cabuk, Refik; Akova, Abdullah; Aksoy, Omer Faruk; Adatepe, Eda
TABATA protocol is considered to be one of the most effective strategies among high-intensity interval training (HIIT) methods. A limited number of studies have compared the chronic effects of cycling-based and calistenic HIIT in TABATA-type. The aim of this study was to compare the chronic effects of a 8-week TABATA-type calisthenic high-intensity interval and high-intensity interval in cycling on aerobic endurance, sprint and maximal strength performance in sedentary men. 17 sedentary males participated in our study. Participants were randomly divided into calisthenic HIIT (n=9) and cycling HIIT (n=8) groups. Training groups were given 3-sessions of exercise per week on non-consecutive days for 8 weeks. Before and after the 8-week training, the body mass, body mass index, fat percentage, 30-m sprint, 1-repetition maximal strength, aerobic power and critical power levels of the participants were determined. No statistically significant different was observed in body mass (p=0.917), body mass index (p=0.928), and body fat ratio (p=0.980) in both training groups. However, both training groups achieved statistically significant improvements in peak power output (p=0.017), maximal oxygen consumption (p=0.040) and critical power (p=0.048), and there was no significant difference in the level of improvement between the groups (p>0.05). There was no statistically significant difference in 1 repetition maximal strength and sprint values of both training groups (p<0.05). TABATA type HIIT performed calistenic provides chronic effects similar to that of interval cycling form.
AtıfScopus12
İncele - MakaleYayıncıda açık erişim2022A Two-Stage ORC Integration to an Existing Fluidized Bed Sewage Sludge Incineration Plant for Power Production in the Scope of Waste-to-Energy
Abusoglu, A.; Tozlu, A.; Anvari-Moghaddam, A.
This paper presents the design, evaluation, and optimization of an electricity generation system based on the two-stage organic Rankine cycle (TS-ORC), which utilizes the waste heat of an existing fluidized bed sewage sludge incineration (FBSSI) facility. The facility incinerates an average of 300 tons per day of sewage sludge with a dry matter content of 22%. After the drying process, the sewage sludge is burned in a fluidized bed combustor, and exhaust gas at a temperature of about 850-900ºC is released due to the combustion. The system provides the energy required to dry the sludge from this exhaust gas. In this study, a TS-ORC is designed to be coupled to the exhaust gas flowlines discharged to the atmosphere at two different points in the FBSSI plant. The exergy efficiency of the FBSSI facility is found to be 70.5%. Three different working fluids are selected to examine the variations of thermodynamic and thermoeconomic performance parameters of the designed TS-ORC system. The highest power generation in the TS-ORC system (183.40 kW) is achieved using R1234yf as working fluid. R1234yf is also the most expensive fluid for electricity generation among the other working fluids (10.57 $/h). The least electricity generation in the TS-ORC (142.70 kW) occurs at the thermoeconomically most affordable cost with R245fa (9.35 $/h).
AtıfScopus2WoS2
İncele - MakaleYalnız künye2022Investigation of the effect of the addition of grain refiner and modifier addition on wear properties in sand and permanent mould casting of A357 and A380 aluminium alloys
Çolak, Murat; Arslan, İbrahim
The aim of this study is to improve the tribological behaviour of aluminium alloys by using grain refiner and modifier. The effects of Al5Ti1B grain refiner and Al10Sr modifier additives on friction and wear properties on A380, A357 alloys produced by pouring sand andpermanent mould casting were investigated. Abrasion tests were carried out under dry conditions against St1040 steel disc using a pin-disk system with 20 N load and 1.0 m/s sliding speed. It was determined that grain refiner and modifier additives decrease the friction coefficient and increase the wear resistance. It was determined that the samples produced by permanent mould casting method decreased the friction resistance by 9% and the abrasion resistance increased by 40% compared to the samples produced in sand mould. The lowest wear rate was obtained in A380 alloy with TiB and Sr added with a value of 4.87 × 10–11 m2/N.
AtıfScopus12WoS10İncele - MakaleYayıncıda açık erişim2022Investigation of the biological treatability of pistachio processing industry wastewaters in a batch-operated aerobic bioreactor
Tırınk, Sevtap; Nuhoğlu, Alper; Kul, Sinan
This study encompasses investigation of treatment of pistachio processing industry wastewaters in a batch reactor under aerobic conditions, calculation of kinetic parameters and comparison of different inhibition models. The mixed microorganism culture used in the study was adapted to pistachio processing industry wastewaters for nearly one month and then concentrations from 50 to 1000 mg L−1 of pistachio processing industry wastewaters were added to the medium and treatment was investigated in batch experiments. The Andrews, Han-Levenspiel, Luong and Aiba biokinetic equations were chosen for the correlations between the concentration of pistachio processing industry wastewaters and specific growth rates, and the kinetic parameters in these biokinetic equations were calculated. The maximum specific growh rate, semi-saturated constant and inhibition constant parameters, included in the Aiba biokinetic equation providing best fit among the other equations, had values calculated as 0.25 h−1, 19 mg L−1, and 516 mg L−1, respectively. The substrate value reaches maximum value and the specific growth rate at this concentration were calculated as 101.379 mg L−1 and 0.1827 h−1, respectively. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus4WoS4
İncele - MakaleYayıncıda açık erişim2022Simultaneous Detection of Ochratoxin A and Aflatoxins in Industrial and Traditional Red and isot Pepper Flakes along with Dietary Exposure Risk Assessment
Oztekin, Sebahat; Karbancioglu-Guler, Funda
This study focused on the co-occurrence of aflatoxins (AFs) and ochratoxin A (OTA) in traditionally and industrially dried red pepper flakes (DRPFs) and isot pepper flakes (IPFs). Following the multitoxin immunoaffinity column (IAC) clean-up, high-performance liquid chromatography coupled with fluorescence detection (HPLC-FLD) was used to quantify AFs and OTA. The limit of detection (LOD) and limit of quantification (LOQ) values were 0.11 and 0.18 μg kg-1(AFB1), 0.04 and 0.08 μg kg-1(AFB2), 0.13 and 0.18 μg kg-1(AFG1), 0.04 and 0.11 μg kg-1(AFG2), and 0.10 and 0.21 μg kg-1(OTA), respectively. AFB1,AFB2, AFG1, and OTA were found to be positive in 93, 74, 17, and 94% of all samples, respectively. The contamination levels in positive samples ranged from 0.23 to 38.69, 0.04 to 2.14, 0.13 to 0.88, and 0.18 to 52.19 μg kg-1for AFB1, AFB2, AFG1, and OTA, respectively, while no AFG2was found above the detection limit (0.04 μg kg-1). None of the industrial isot peppers exceeded the European Union limits, while the levels of AFB1(5 μg kg-1), total AFs (10 μg kg-1), and OTA (20 μg kg-1) of the traditional peppers were above the limit by 30% (16/54), 26% (14/54), and 4% (2/54), respectively. Co-occurrence of AFB1-AFB2-OTA was the most frequent, accounting for 54% (29/54) of all samples. At the upper bound (UB), estimated average exposure to AFB1, total AFs, and OTA was determined to be 0.175, 0.189, and 0.124 ng kg-1bw day-1in all samples, respectively. The margin of exposure (MoE) value of AFB1and total AFs was found to be 977 and 909, indicating high health concerns compared to OTA (MoE >10,000). AFB1and total AFs may result in 0.0058 and 0.0062 liver cancer cases/100,000 person/year at UB, respectively, and weekly OTA exposure was 0.868 ng kg-1bw, well below the provisional tolerable weekly intake, hence not of health concern. AFs exposure could endanger health, whereas OTA posed no toxicological concerns through dried red pepper consumption.
AtıfScopus17WoS17İncele - Editöre MektupYayıncıda açık erişim2022Three new records for the flora of Turkey: Campanula lyrata subsp. icarica (Campanulaceae), Erysimum aureum (Brassicaceae) and Stachys benthamiana (Lamiaceae)
Özdöl, Tuǧkan; Güner, Özal; Sefali, Abdurrahman; Akçiçek, Ekrem; Dirmenci, Tuncay; Yildirim, Hasan
AtıfScopus6WoS5İncele - MakaleYalnız künye2022Optimization of Biocatalytic Production of Enantiopure (S)-1-(4-Methoxyphenyl) Ethanol with Lactobacillus senmaizuke Using the Box–Behnken Design-Based Model
Kavi, Mervenur; Özdemir, Akın; Dertli, Enes; Şahin, Engin
Enantiomerically pure (S)-1-(4-methoxyphenyl) ethanol is a significant molecule for the production of various drug intermediates. (S)-1-(4-methoxyphenyl) ethanol was synthesized from 4-methoxyacetophenone using Lactobacillus senmaizuke as a biocatalyst. In addition, optimization of experimental conditions is important to analyze the role of culture parameters for catalytic bioreduction reactions. For this particular purpose, the experimental conditions of pH, incubation period, temperature, and agitation speed were investigated with the Box–Behnken experimental design-based proposed optimization model. (S)-1-(4-methoxyphenyl) ethanol, which can be used for the synthesis of antihistamines, including diphenhydramine hydrochloride and loratadine cycloalkyl [b] indoles that have the treatment function for an allergic response, was obtained in > 99% conversion, > 99% enantiomeric excess and 96% yield with whole cells of L. senmaizukei at this optimization conditions: pH = 5.80, the temperature = 29 °C, incubation period = 50 h, and agitation speed = 155 rpm. The bioreduction of 4-methoxyacetophenone efficiency was importantly affected by the quadratic and linear effects of experimental design parameters. Besides, the results demonstrate the importance of design parameters for catalytic bioreduction reactions. It is also concluded that the results show the effectiveness of the Box–Behnken experimental design-based proposed model to obtain optimum operating conditions of design parameters for catalytic bioreduction reactions.
AtıfScopus4WoS4İncele - MakaleYalnız künye2022Broadband Soil Permittivity Measurements Using a Novel De-Embedding Line-Line Method
Hasar, Hafize; Hasar, Ugur C.; Kaya, Yunus; Oztas, Taskin; Canbolat, Mustafa Y.; Aslan, Nevzat; Ertugrul, Mehmet; Ramahi, Omar M.
A new de-embedding line-line method has been proposed for accurate complex relative permittivity ( ε ᵣ ) determination of soil samples loaded into an EIA 1-5/8' coaxial transmission line measurement system. The method has three main features. First, it bypasses the requirement of calibration of this system by using only two identical coaxial lines with different lengths. Second, it does not need any numerical technique for ε ᵣ determination. Third, it does not require knowledge of electromagnetic properties and thickness information of the bead used for supporting soil samples. The method is next validated by simulations performed using a full 3-D electromagnetic simulation program (CST Microwave Studio) and by ε ᵣ measurement of a polyethylene (PE) material. Finally, ε ᵣ values of three air-dried and water-saturated soil samples having 90% or more sand content with different electrical conductivities (ECs) and gathered from different areas of the city Gaziantep in Turkey, were measured.
AtıfScopus18WoS16İncele - MakaleYalnız künye2022Evaluation of γ-rays and neutron shielding parameters of high dense bismo-boro-tellurite glasses: Comparative study
Şakar, E.; Özpolat, Ö.F.; Alım, B.; Alsaif, Norah A.M.; Rammah, Y.S.
The main high energy radiation-matter interaction parameters of the 30B2O3-(70-x)TeO2-xBi2O3, where x = 40, 50, 60 and 70 mol% (BTB) glasses have been studied in the wide energy range. The theoretical calculations were made for some special X and γ-ray energies emitted from Fe (55), Am (241), Cs (137) and Co (60) radioactive sources for photon energies in the range of 15 keV - 15 MeV. All evaluated radiation shielding parameters were compared with some selected concretes (Ordinary concrete (OC), Hematite-Serpenite (HS) and Basalt-Magnetide (BM)), and glasses (Te and Pb based). The BTB- glasses have higher mass attenuation coefficient (MAC) values than other glasses (Te and Pb based) and concretes (OC, HS, and BM). The half value layer (HVL) of the investigated BTB-glasses has the following trend: OC > HS > BM > Te-Glass > Pb-glass > BTB40 > BTB50 > BTB60 > BTB70. In terms of mean free path (MFP), the BTB70 coded glass has the lowest MFP values due to the highest Bi2O3 content. In terms of the Zeff values of BTB coded glasses vary between 70 and 75 at the lowest energy level. The effective atomic number (Zeff) values in this energy region were 48.974 and 63.102 for Te and Pb glasses, respectively, and 13,339, 15.520 and 15.894 for OC, HS and BM concretes. The BTB-coded glasses have lower exposure buildup factor (EBF) than all other glass and concrete up to 3 MeV photon energies. The energy absorption buildup factor (EABF) values range from 1 to 4.2 for all samples at 1 MFP and at 40 MFP values, it reaches 108 for BTB coded glasses and 1010 for Te-based glass. Results confirmed that BTB- glasses, especially BTB70 glass sample can be used in applications requiring radiation safety.
AtıfScopus17WoS16İncele - MakaleYalnız künye2022Synthesis of 7-azaindole based carbohydrazides and 1,3,4-oxadiazoles; Antioxidant activity, α-glucosidase inhibition properties and docking study
Izgi, Samet; Sengul, Ibrahim F.; Şahin, Engin; Koca, Mehmet Serdar; Cebeci, Fatma; Kandemir, Hakan
In this current work, 7-azaindole based 1,3,4-oxadiazoles have been successfully prepared by treatment of 3-(hydrazonomethyl)-7-azaindole with the different acyl chlorides or acetic anhydrides to give the corresponding carbohydrazides, followed by iodine mediated synthetic protocol in order to afford the corresponding 2,5-disubstituted 1,3,4-oxadiazoles. The full characterization data of the novel compounds were obtained by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry and single crystal X-ray diffraction techniques. The antioxidant activity and α-glucosidase inhibition potential of the prepared compounds are examined by in vitro assays. The targeted hydrazide linked 7-azaindoles and their corresponding cyclized form 1,3,4-oxadiazoles exhibited inhibitory potential with IC50 values ranges between 0.46 and 24.92 mM. Plausible binding mode and interaction of ligands with α-glucosidase enzyme have been studied by molecular docking, supporting the experimental results.
AtıfScopus28WoS27İncele - MakaleYalnız künye2022Production of enantiomerically enriched chiral carbinols using whole-cell biocatalyst
Baydaş, Yasemin; Kalay, Erbay; Şahin, Engin
Biocatalytic asymmetric reduction of ketone is an efficient method for the production of chiral carbinols. The study indicates selective bioreduction of different ketones (1–8) to their respective (R)-alcohols (1a–8a) in low to high selectivity (0- >99%) with good yields (11–96%). In this work, whole-cell of Lactobacillus kefiri P2 catalysed enantioselective reduction of various prochiral ketones was investigated. (R)-4-Phenyl-2-butanol 2a, which is used as a precursor to antihypertensive agents and spasmolytics (anti-epileptic agents), was obtained using L kefiri P2 in 99% conversion and 91% enantiomeric excess (ee). Moreover, bioreduction of 2-methyl-1-phenylpropan-1-one substrate 8, containing a branched alkyl chain and difficult to asymmetric reduction with chemical catalysts as an enantioselective, to (R)-2-methyl-1-phenylpropan-1-ol (8a) in enantiomerically pure form was carried out in excellent yield (96%). The gram-scale production was carried out, and 9.70 g of (R)-2-methyl-1-phenylpropan-1-ol (8a) in enantiomerically pure form was obtained in 96% yield. Also especially, the yield and gram scale of (R)-2-methyl-1-phenylpropan-1-ol (8a) synthesised through catalytic asymmetric reduction using the biocatalyst was the highest report so far. The efficiency of L kefiri P2 for the conversion of the substrates and ee of products were markedly influenced by the steric factors of the substrates. This is a cheap, clean and eco-friendly process for production of chiral carbinols compared to chemical processes.
AtıfScopus5WoS5İncele - MakaleYayıncıda açık erişim2022Contributions on the southern distribution of Vespertilio murinus Linnaeus, 1758 (Chiroptera: Vespertilionidae) from Türkiye
Karataş, Ahmet; Bulut, Şafak; Sefali, Abdurrahman; Toprak, Ferhat; Şahin, Mehmet Kürşat; Özkurt, Şakir Önder
Vespertilio murinus Linnaeus, 1758, has a wide distribution from France to Japan, and from Iran in the south to Scandinavia and Russia in the north. The only records of the parti-coloured bat, Vespertilio murinus known from Turkey so far were based on subfossils, remains from owl pellets, and ultrasound recordings. We present the first records of live individuals from two Turkish provinces, Ardahan and Bayburt. Additionally, based on echolocation call records, its known distribution in the Anatolian Peninsula was proved to be wider. The global distribution of the species has been mapped by using ecological niche modelling. The results revealed that its distribution is highly influenced by precipitation dynamics. Although no cases of domestic cat predation on bats have previously been documented in Turkey, this paper also provides the first case study of V. murinus predated by a domestic cat in Ardahan, in November 2003.
AtıfScopus3WoS2İncele - MakaleYalnız künye2022Bioactive and technological properties of an α-D-glucan synthesized by Weissella cibaria PDER21
Yilmaz, Mustafa Tahsin; Ispirli, Humeyra; Taylan, Osman; Alamoudi, Mohammed; Dertli, Enes
A slimy-mucinous-type colony of EPS-producing Weissella cibaria PDER21 was isolated and identified. The monomer composition was glucose, showing that the EPS is a glucan type homopolysaccharide, The core structure of (1 → 6)-linked α-D-glucose units including (1 → 3)-linked α-D-glucose branches at a ratio of 93.4/6.6 was revealed by 1H and 13C NMR spectra and confirmed by FTIR analysis. The glucan showed a superior thermal stability with almost no degradation in structure up to 300 °C. XRD analysis revealed the amorphous structure while SEM analysis confirmed the layer-like morphology. The glucan had an antioxidant activity (89.5%), water-holding capacity (103.7%) and water solubility index (80.7%) values, suggesting that the glucan had a strong level of antioxidant properties; good water binding capacity and excellent solubility. The glucan PDER21 is a polysaccharide possessing a good combination of technical and functional attributes, suggesting a great deal of potential for use in the food industry.
AtıfScopus42WoS41İncele - MakaleYayıncıda açık erişim2022Investigation of CYP2E1 and Caspase-3 Gene Expressions in COVID-19 patients
Karabulut Uzuncakmak, S.; Dirican, E.; Naldan, M.E.; Kesmez Can, F.; Halıcı, Z.
Background: COVID-19 pandemic spread around the world like an infectious disease that presents waved effects on patients. Some patients needed ICU and respiratory support. Some patients only had flu-like symptoms. Cytokine storm and elevated ROS were serious problems for treatment. Apoptotic genes and CYP Family are part of these mechanisms. Aim: In this study, our aim was to examine the gene expression CYP2E1 and Caspase-3 in patients with COVID-19 infection. Method: 60 COVID-19(+) patients (ICU and non-ICU patients) and 30 healthy volunteers were enrolled to study. To measure the level of gene expression qPCR was used. The 2-ΔΔCt method was utilized to analyze gene expression. Results: The expression of CYP2E1 and Caspase-3 genes showed a significant discrepancy between patients and healthy individuals. Caspase-3 expression increased (p=0,0041) but CYP2E1 expression decreased (p=0,0214) in COVID-19 patients compared to healthy individuals. Both levels of gene expression were lower in patients with affected lungs than patients with unaffected lungs (p<0,05). Laboratory findings including d-Dimer, LDH, platelet count, lymphocyte count were related to both gene expressions (p<0,05). We found no correlation between CYP2E1 and Caspase-3 expressions. Conclusion: The expression of Caspase-3 demonstrated apoptotic situations of patients but was not related to the CYP2E1 expression level. CYP2E1 gene expression is an important actor to metabolize endogens and xenobiotics however, COVID-19 patients demonstrated decreased CYP2E1 expression. CYP2E1 and Caspase-3 gene expression levels may be used as a diagnostic tool for COVID-19 patients.
AtıfScopus8WoS5İncele - MakaleYalnız künye2022Inclusive Pedagogical Content Knowledge of Mathematics Teachers: Learning Disabilities vs. Hearing Impairments
Güven, Dilsad; Gürefe, Nejla; Arıkan, Ahmet
This study aims at investigating inclusive pedagogical content knowledge (IPCK) of mathematics teachers who teaches in inclusive classes including learning disabilities (LD) students or hearing impairments (HI) students in the context of angle concept. The study is a cross-case study which facilitates the comparison as one of the multiple case designs. The participants of the study are six Turkish mathematics teachers, three of them have experience of teaching to students with LD, and three of them students with HI. The data of the study is collected via semi-structured clinical interviews, and analysed using cross-case analysis. According to the findings of the study that examines the IPCK of teachers regarding the concept of angle, it can be said that teachers’ definitions of angle and their teaching strategies are insufficient. Additionally, it was found that HI teachers used much more multiple presentation such as speaking, writing, drawing shapes, and gestures than LD teachers.
AtıfScopus4WoS1İncele - MakaleYalnız künye2022Comparison of theoretical frameworks of doctoral theses on the field of instructional technology: The Turkey-US case
Şimşek, Eda Saka; Atila, Gülşah; Aydın, Abdulkerim; Reisoğlu, İlknur; Göktaş, Yüksel
Although there are suggestions for writing the theoretical framework in the literature, studies on how all sections of research should be structured based on the theoretical framework are limited. The current research compared the structuring of doctoral theses' theoretical frameworks in the field of instructional technology produced in Turkey and the US. Two hundred doctoral theses were subjected to content analysis based on the list of criteria developed by the researchers. The data collection tool includes the criteria of formality, language, definition and association, purpose and significance, methodological procedures, and presentation and interpretation of results. Independent factorial ANOVA were used to determine whether country and method affected the data obtained from the analyzed theses. The analysis of the data showed that the US-based theses were structured in accordance with the established criteria in all aspects except for purpose and importance. Method did not affect consistency with the criteria. The results of the study are anticipated to guide graduate students, thesis advisors, and researchers preparing theses and articles.
AtıfScopus3WoS2İncele - MakaleYayıncıda açık erişim2022Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1α in SARS-Cov-2 infected patients
Karabulut Uzunçakmak, Sevgi; Naldan, Muhammet Emin; Dirican, Ebubekir; Kerget, Ferhan; Halıcı, Zekai
Background: Coronavirus-19 is still considered a pandemic that influences the world. Other molecular alterations should be clearer besides the increasing cytokine storm and pro-inflammatory molecules. Hypoxic conditions that induce HIF-1α lead to stimulate gene expression of STC-2 that targets PAPP-A expression. This study aimed to determine gene expression levels of PAPP-A, STC-2, and HIF-1α in COVID-19 infection. We also aimed to reveal the relationship of these genes with laboratory and clinical data of COVID-19 patients. Materials and Results: We extracted RNA from peripheral blood samples of COVID-19(+) and COVID-19(−) individuals. The real-time PCR method was used to measure mRNA expression of PAPP-A, STC-2, and HIF-1α. Gene expression analysis was evaluated by the 2−ΔΔCt method. PAPP-A, STC-2, and HIF-1α mRNA expressions of severe patients were higher than healthy individuals (p = 0.0451, p = 0.4466, p < 0.0001, respectively). Correlation analysis of gene expression patterns of severe patients demonstrated a positive correlation between PAPP-A and STC-2 (p < 0.0001, r = 0.8638). Conclusion: This is the first study that investigates the relation of PAPP-A, STC-2, and HIF-1α gene expression in patients with COVID-19 infection. Besides the routine laboratory findings, PAPP-A, STC-2, and HIF-1α mRNA expressions may be considered to patients’ prognosis as a sign of increased cytokines and pro-inflammatory molecules.
AtıfScopus6WoS6İncele - MakaleYalnız künye2022Analysing the potential of transport triggered architecture for lattice-based cryptography algorithms
Akçay, Latif; Yalçın, Berna Örs
Lattice-based structures offer numerous possibilities for post-quantum cryptography. Recently, many post-quantum cryptography algorithms have been built on hard lattice problems. The three of the remaining four algorithms in the final round of the NIST Standardization Process rely on lattice-based methods. However, suitable processor architectures for these algorithms have not been sufficiently investigated. This study examines the potential advantages of transport triggered architecture for these algorithms. We compare popular 64-bit RISC-V processors with our conceptual transport triggered architecture processor over reference software implementations. Our processor provides better results than RISC-V competitors, regardless of the algorithm. It seems to be up to 3× faster, 1.6×–2× smaller, and consumes 1.3×–3.6× less energy than the compared RISC-V cores. Thus, an alternative base architecture is proposed for post-quantum cryptography processor development for embedded systems. The most critical shortcoming of the proposed architecture is the lack of compatible intellectual property core support for system-on-chip designs. We share comparative analyses with test results for different core configurations.
AtıfScopus3WoS2İncele - MakaleYayıncıda açık erişim2022Anatomy, trichome micromorphology and phytochemical profile of Stachys rizeensis R.Bhattacharjee from Turkey
Gerçek, Yusuf Can; Acar Şahin, Aydan; Ecem Bayram, Nesrin; Çelik, Saffet; Sefalı, Abdurrahman; Gıdık, Betül; Cevahir Öz, Gül; Pınar, Nur Münevver
In recent years, the popularity of natural products and natural product formulations has increased due to their beneficial effects on health. As a part of this trend, Lamiaceae family members have attracted attention due to their rich bioactive properties. Although the Stachys rizeensis R.Bhattacharjee plant is an endemic plant species in Turkey, no studies focus on its characterization. Hence, the present study aims to demonstrate the anatomical, morphological and phytochemical characterization of S. rizeensis in Turkey. In the first stage of the study, anatomical and trichome morphological characterization was performed to contribute to the taxonomic definition of S. rizeensis was found to be anatomically different from some other previously studied Stachys sp. by showing lacunar collenchyma type, uncertain cambium at the corners, two or three rows of endodermis in certain areas in the stem and two rows of palisade parenchyma, capitate and peltate glandular trichomes in the leaf. In the second stage, the phenolic profile, total phenolic/flavonoid content and antioxidant activity of the plant extracts prepared using solvents with different polarities (ethanol, methanol, water, ethyl acetate and hexane) were tested to determine the phytochemical content of the plant. The phytochemical analysis supported by chemometric analysis (PCA and HCA) revealed that methanol was the most efficient organic solvent for the extraction of the phytochemical compounds of the plant. Additionally, it was observed that chlorogenic acid (1842.40–217,086.19 mg/kg), verbascoside (2591.43–204,429.81 mg/kg), luteolin (3579.56–88,636.14 mg/kg) and kaempferol (9706.30–50,340.93 mg/kg) compounds were present at maximum levels in this plant, in which 31 different phenolic compounds were scanned using LC-MS/MS. In addition, results obtained from the phytochemical analysis revealed that S. rizeensis is a valuable plant that can be used for medical protection/treatment and that it could also have a variety of culinary applications. The present study served as the first original report regarding the chemical profile and anatomical characteristics of S. rizeensis (Lamiaceae) from Turkey.
AtıfScopus4WoS4İncele - BildiriYalnız künye2022Ultrasonicate-assisted preparation of eumelanin-loaded nano/microparticles based on polylactide stereocomplex
Putri, Oceu Dwi; Petchsuk, Atitsa; Bayram, Sinan; Opaprakasit, Pakorn
The utilization of ultrasonication in the preparation of polymeric nano/microparticles has attracted vast attention due to its simplicity with low cost and high energy efficiency. The occurrence of acoustic cavitation generated by the ultrasonication process can enhance droplet disintegration, allowing the improved stability of emulsions. In this study, eumelanin-loaded nano/microparticles were prepared by employing polylactide stereocomplex (sc-PLA) formed by blending of poly(D-lactide-caprolactone-D-lactide), P(DLA-b-CL-b-DLA), triblock copolymer with linear poly(L-lactide), PLLA. The particles were prepared through an oil in water emulsion (O/W) technique followed by a solvent evaporation. The effect of ultrasonication on the encapsulation efficiency and physicochemical properties of the nano/microparticles was evaluated. The results showed that ultrasonication treatment could control nano/microparticles' shape, size, and size distribution, which enhanced the particle stability and the entrapment efficiency of eumelanin. Particle size distribution of ultrasound-assisted nano/microparticles was in a range of 0.38–135 μm, while those without ultrasonication had a broader distribution from 0.38–153 μm. Higher zeta potential was also observed in the ultrasound-assisted nano/microparticles, reflecting their higher suspension stability. The ultrasonication treatment led to higher eumelanin encapsulation efficiency (46.6%) with higher thermal stability and crystallinity, promoted by the formation of higher contents of the stereocomplex crystallites. The results confirm that ultrasonicate-assisted emulsification can be effectively used to fabricate the functional eumelanin-loaded nano/microparticles.
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