Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Kırbaş, Zila Özlem(4)
- Bayraktar, Bülent(3)
- Bozok, Ümmü Gülşen(3)
- Ozcan, Gulbahar Boyuk(3)
- Aktaş, Elif Odabaşı(2)
- Erkılıç, Tugçe Orkun(2)
- Ag, Aliriza(1)
- Ay, Mustafa Ertan(1)
- Battal, Fetullah(1)
- Bülbül, Ali Savaş(1)
- Derici, Didem(1)
- Dirican, Ebubekir(1)
- Elmalı, Kübra(1)
- Erdal, Mehmet Emin(1)
- Erkılıç, Ali Ozan(1)
- Güçlü, Esranur(1)
- Işık, Hafsa Kübra(1)
- Karabulut, Sevgi(1)
- Karakas, Ümıt(1)
- Kenar, Ayse Nur Inci(1)
- Metin, Tuba(1)
- Ozcan, Halil(1)
- Ozdemir, Gazi(1)
- Semerci, Vahide(1)
- Sönmez Sarı, Ebru(1)
- Süheyb, Okur(1)
- Turan, Merve(1)
- Uzunçakmak, Sevgi Karabulut(1)
- Yeloğlu, Çağdaş Hünkar(1)
- Ziblak, Alper(1)
- Çevik, Kenan(1)
- Özcan, Halil(1)
- Özdemir, Gurbet Doğru(1)
- Özdemir, Serap Çetinkaya(1)
- Özkan, Hava(1)
- Şahin, Emel(1)
Yayınlar
- MakaleAçık Erişim2026Tıp Fakültesi Öğrencilerinde Sınav Kaygısının Fizyolojik Belirtilerini Azaltmada Ardıç ve Kekik Uçucu Yağlarının Etkinliği
Erkılıç, Tugçe Orkun; Bayraktar, Bülent; Bozok, Ümmü Gülşen; Ozcan, Gulbahar Boyuk
Tıp öğrencileri, bilişsel ve akademik performansı olumsuz etkileyen sınav kaygısıyla mücadele etmektedir. Aromaterapi, farmakolojik tedavilere alternatif olarak popüler hale gelmektedir. Bu çalışma, ardıç ve kekik esansiyel yağlarının lisans öğrencilerinin sınav kaygısını psikofizyolojik olarak nasıl etkilediğini incelemektedir. Sınavlara giren öğrencilerde ardıç ve kekik aroması inhalasyonu asprosin, siklik guanozin monofosfat yanıt elementi bağlayıcı protein (CREB), kortizol ve sınav kaygısı üzerinde test edilmiştir. Yöntem: Tıp Fakültesi'nden 18-25 yaş arası 80 sağlıklı öğrencinin rastgele bir örneği, final sınavları sırasında toplanmıştır. Katılımcılar kendi kontrolleriydi ve aromaterapiden önce ve sonra tükürük alındı. Tükürük örnekleri ELISA kullanılarak Asprosin, CREB ve kortizol için test edildi. Kalp hızı, oksijen satürasyonu, sistolik basınç, diyastolik basınç ve vücut sıcaklığı aroma inhalasyonundan önce ve sonra izlenmiştir. Bulgular: Bu çalışmanın bulgularına göre, ardıç ve kekik aromaterapisinin tükürük ortalama Asprosin, CREB ve kortizol hormon düzeylerini artırmada etkili olduğu, en anlamlı düşüşün ise ardıç aromaterapisi alan gruplarda olduğu tespit edildi (p<0.001). Ardıç aromaterapi uygulaması Sistolik Kan Basıncı (SKB) ve Diyastolik Kan Basıncı (DKB)'yi etkilemiş (p<0.05) ancak Kalp Atım Hızı (KAH), Periferik Kapiller Oksijen Satürasyonu (SPO2) veya sıcaklığı etkilememiştir (p>0.05). Kekik aromaterapisi SBP, DBP, HR, SPO2 veya sıcaklığı etkilememiştir (p>0.05). Sonuç: Hafıza ve duyguları kontrol eden limbik sistem koku ile bağlantılıdır. Çalışmamız, koku inhalasyonunun sınav sırasında üniversite öğrencilerinde Asprosin, CREB, kortizol ve diğer fizyolojik göstergeleri etkilediğine dair özgün kanıtlar ortaya koymuştur ve sınav kaygısının giderilmesinde destekleyici bulgular sunmaktadır.
AtıfOpenAlex2
İncele - MakaleAçık Erişim2025Fear of COVID-19 and Depression in Pregnant Women and New Mothers: A Cross-Sectional Study
Kırbaş, Zila Özlem; Sönmez Sarı, Ebru; Aktaş, Elif Odabaşı; Işık, Hafsa Kübra
Purpose: The objective of the study was to determine COVID-19 fear and depression in pregnant women and new mothers. Methods: The study sample consisted of pregnant women and new mothers, who gave birth in the last 1 year, aged 18 years or older, living in a province in the Eastern Black Sea region (n = 259). Data werecollected through a personal-information form, COVID-19 Fear Scale, and PHQ-9. Results: Women's COVID-19 Fear Scalescore mean was 15.28±6.42 and their PHQ-9 mean score was 9.27±5.31. Multiple linear regression analysis showed that the variables of PHQ-9 (p=0.000), educational background (p=0.029), occupational status (p=0.0015) and socioeconomic status (p=0.012) were statistically significant predictors of COVID-19 fear. All variables were found to explain the variance in COVID-19 Fear Scale scores to 16% (R2= 0.164). Conclusion: The women in this study appeared to have a moderate level of COVID-19 fear. PHQ-9, educational background, occupational status, and socioeconomic status were predictors of women's COVID-19 fear. The pandemic period, which is a public health emergency, affects not only the physical health but also the psychological health of pregnant and post-partum women, a particularly vulnerable group. It is very important for midwives and nurses to effectively screen pregnant and post-partum women, particularly vulnerable group, for symptoms of depression and fear, and to provide them with accurate and up-to-date information to protect and improve their health.
- MakaleAçık Erişim2024Muhasebe meslek mensuplarında duygusal emek ve örgütsel bağlılığın ilişkisi; bayburt, gümüşhane illerinde bir araştırma
Ag, Aliriza; Elmalı, Kübra; Güçlü, Esranur
Bu çalışmanın amacı, duygusal emek ve örgütsel bağlılığın muhasebe meslek mensupları üzerindeki ilişkisini ortaya çıkarmaktır. Analizler sonucunda duygusal emek ve örgütsel bağlılık arasında istatistiksel olarak anlamlı bir ilişki olmadığı elde edilmiştir. Duygusal emek alt boyutlarını oluşturan yüzeysel davranış, derin davranış ve samimi davranış ile örgütsel bağlılık alt boyutları olan duygusal bağlılık, devam bağlılığı ve normatif bağlılık arasında ki ilişkilerin belirlenmesi amacıyla gerçekleştirilen analiz neticesinde, sadece samimi davranış boyutu ile devam bağlılığı boyutu arasında pozitif yönlü bir ilişki tespit edilmiştir. Diğer alt boyutlar arasında pozitif ya da negatif yönlü ilişki tespit edilmemiştir.
- MakaleYalnız künye2024Analitik psikolojinin bireyleşme kavramı ile tasavvufun kemâl kavramına kıyaslamalı bir yaklaşım
Süheyb, Okur
Araştırmada yüzlerce yıllık bir geçmişe dayalı tasavvufî öğretinin bireyi ulaştırmayı hedeflediği “Kemâl” noktası ile analitik psikolojinin kurucusu Carl Gustav Jung tarafından geliştirilen “Bireyleşme” sistemi kıyaslanarak ele alınmıştır. Tasavvuf bireyi kemâle erdirmek amacıyla ortaya koyduğu ilkelerle sistematik bir yapıdır. İslamiyet çatısı altında var olan bu yapı Müslüman bireylerin kendilerine ve hayatlarına anlam yükleyen manevî bir eğitim metodu olarak birçok mistik öğretiyle benzeşmektedir. Bu mistik öğretilerden biri de Jung’un ortaya koyduğu bireyleşmedir. İnsanın psişik bütünlüğünü hedef alan bu yapı tasavvuf gibi kendi içerisinde belli ilkeleri göz önünde bulundurmaktadır. Bireyleşme dini bir olgu olmamakla birlikte ulaştığı noktada Tanrı vardır ve insanın aşkınlığını hedef alan yapısı ona mistik bir öğreti niteliği de kazandırmaktadır. Var olan bütün mistik öğretiler, insanın içinde potansiyel olarak bulunan aşkın olana-hakikate ulaşma ihtiyacının giderilmesi amacına matuftur. Tasavvuf ve bireyleşme yöntemleri itibariyle birbirinden farklı ve birçok ayrıştığı nokta vardır fakat hedefleri itibariyle birbirine yakındır. Çalışmada bu iki sistemin farklılıklarından ziyade ortak yönleri üzerinde durulmuştur.
AtıfTR Dizin1İncele - MakaleAçık Erişim2024Mediating Role of Emotional Intelligence in the Relationship between Hospital Perception and Fear of Medical Procedures in Children
Kırbaş, Zila Özlem
Aim: This study investigated the relationship between children's hospital perceptions, their fear of medical procedures, and the role of emotional intelligence as a potential mediator. Material and Method: The population of the research consists of 4th grade students (10-year-old students) studying in primary schools in the 2023-2024 academic year. The study included 343 students and employed a relational-cross-sectional-descriptive design. Data were collected using the Personal Information Form, Medical Procedure Fear Scale, Hospital Perception Scale for Healthy Children, and Ten-Year-Old Emotional Intelligence Scale. Data were analyzed with IBM SPSS V23 and IBM AMOS V24. Compliance with normal distribution was examined with the assumption of skewness, kurtosis, and multiple normality. Path analysis was used to test the mediator model, and Maximum Likelihood (ML) was used as the calculation method. Analysis results were presented as frequency (percentage) for categorical variables, mean±standard deviation, and median (minimum–maximum) for quantitative variables. The significance level was taken as p<0.05. Results: The study found that children's hospital perceptions predicted their fear of medical procedures. Specifically, there was a statistically significant positive relationship between hospital perception and fear of medical procedures (β=0.565; p<0.05). According to the mediated structural model analysis results, hospital perception had a statistically significant negative effect on the mediator variable emotional intelligence (β=-0.327; p<0.05). By including the mediator variable emotional intelligence in the model, the path coefficient between hospital perception and fear of medical procedures was statistically significant (β=0.554; p<0.05). Conclusion: In the study, it was found that emotional intelligence, the mediator variable, played a role in the relationship between hospital perception and fear of medical procedures.
- MakaleAçık Erişim2024The impact of aromatherapy on glossophobia among medical students: A study on cortisol levels and stress reduction
Battal, Fetullah; Bayraktar, Bülent; Bozok, Ümmü Gülşen; Ozcan, Gulbahar Boyuk
Glossophobia (fear of public speaking, presentation anxiety) is an anxiety disorder characterized by extreme fear and anxiety about public speaking. Glossophobia is a very common phobia worldwide, reportedly affecting 75% of the population. This study aims to examine the effects of different aroma inhalations (Thyme and Juniper) on public speaking anxiety, and salivary cortisol hormone levels in university students. The sample of the research consisted of a total of 104 university students, male and female, between the ages of 18-20. In the first step, cortisol hormone levels were determined using the ELISA technique in the saliva samples taken from the university students included in the study. The average salivary cortisol hormone level and public speaking anxiety levels of the university students participating in the study showed a positive and statistically significant relationship (p=0.001). There is a significant negative correlation between the participants' public speaking anxiety and post-thyme oil status at a 99% confidence level and a 1% significance level, r=-.318. When public speaking anxiety and juniper oil were analyzed, a significant negative relationship was found at r=-.290, a 99% confidence level, and a 1% significance level. It was also concluded that inhalation of 2% thyme essential oil in individuals with high glossophobia is both safe and beneficial in reducing anxiety levels.
AtıfOpenAlex4TR Dizin2İncele - MakaleAçık Erişim2024Investigation of the relationship between orthorexic tendencies and some anthropometric measurements and variables in university students
Erkılıç, Tugçe Orkun; Bayraktar, Bülent; Bülbül, Ali Savaş; Bozok, Ümmü Gülşen; Erkılıç, Ali Ozan; Ozcan, Gulbahar Boyuk; Turan, Merve
Orthorexia nervosa (ON) is a type of eating disorder marked by an excessive preoccupation with eating healthily to preserve and promote health, which surpasses normal levels of concern. This study aims to investigate the correlation between orthorexic tendencies, anthropometric measurements, and several other characteristics among university students. A cross-sectional study was done with a sample size of 307 university students from various departments, consisting of 228 females and 79 males. The data-gathering process consisted of administering a demographic information form and the ORTO-11 questionnaire. Anthropometric measurements, such as weight, height, waist circumference, hip circumference, and chest circumference, were measured. In addition, Body Mass Index (BMI) was calculated. The TANITA BC-418 equipment was used to measure the weight of the participants, while a flexible tape measure was used to measure their height, waist circumference, hip circumference, and chest circumference. The BMI was calculated by the individual's weight (in kilograms) by the square of their height (in meters). The data analysis encompassed the utilization of descriptive statistics, t-tests, variance analysis, and Pearson correlation analysis. A score of 25 or lower on the ORTO-11 scale was categorized as orthorexic, whereas a score higher than 25 was deemed normal. The average age and orthorexia scores of the subjects were 20.81±1.86 and 27.76±4.42 for females, and 21.38±4.14 and 28.11±4.37 for males, respectively. It was determined that 29.3% of the participants were found to display orthorexic tendencies, while the remaining 70.7% did not. There were no statistically significant variations in age, hip circumference, and orthorexia scores across genders (p>0.05). No statistically significant relationship was found between the total orthorexia scores and BMIs of the individuals (r=-.051, p>0.05). ON is associated with psychological and social complications, which in turn contribute to the development of disordered eating patterns. The results of this study indicate that determining the frequency of orthorexic tendencies among university students may contribute to the development of strategies for its prevention.
AtıfOpenAlex1İncele - MakaleAçık Erişim2024Relationship between perceptions of family-to-family support, general well-being, and psychological resilience of mothers with children with special needs
Kırbaş, Zila Özlem; Şahin, Emel
This study aimed to investigate the association between perceptions of family-to-family support and the general well-being and psychological resilience of mothers raising children with special needs. Employing a descriptive correlational research design, the study included mothers of children aged 0-18 residing in a city center in northeastern Türkiye. Data collection was conducted through face-to-face interviews using the Personal Information Form, Brief Psychological Resilience Scale, General Well-Being Scale Short Form, and Family-to-Family Support Perception Scale for Families of Disabled Children. The results revealed a positive and significant relationship between mothers' perceived level of family-to-family support and their psychological resilience (β=0.437, p<0.01). Furthermore, a positive relationship was observed between mothers' general well-being levels and perceived support (β=0.315, p<0.05). However, no significant relationship was found between general well-being levels and psychological resilience (β=0.189, p>0.05). These findings underscore the significant connections between perceived family-to-family support, general well-being, and psychological resilience among mothers of children with special needs. They suggest a critical need for developing enhanced social and psychological support mechanisms to alleviate the stress and difficulties experienced by these mothers.
AtıfOpenAlex1İncele - MakaleAçık Erişim2024The Relationship Between Body Image and Anxiety and Depression in Pregnant Women in Türkiye
Kırbaş, Zila Özlem; Özkan, Hava; Aktaş, Elif Odabaşı
Objective: This study was conducted to examine the relationship between body image and anxiety and depression during pregnancy. Materials and Methods: A cross-sectional and correlational study was conducted with 300 pregnant women in a public hospital and family health centers between October 2022 and February 2023. Data were collected with the Personal Information Form, Body Understanding Scale for Pregnancy (BUMPs) and Hospital Anxiety and Depression (HAD) Scale. Mean, percentage, Independent Sample t-test, One-Way ANOVA, Correlation and Multiple Linear Regression were used for data analysis. Results: Correlation analysis showed significant positive correlations between Body Image and Anxiety and Depression in Pregnancy. In the multiple linear regression analysis, it was found that 13% (R2 adj. = 0.13) of the variance in the HADS-A subscale variable was explained by independent variables. It was found that 27% of the variance in the HAD-D subscale variable (R2 adj.= 0.27) was explained by independent variables. Conclusions: This study showed that body image during pregnancy is a multifaceted problem that affects anxiety and depression in pregnant women. The high prevalence of prenatal anxiety and depression highlights the importance of this condition as a public health problem.
AtıfOpenAlex2İncele - MakaleYalnız künye2023Majör depresyon hastalarında BDNF gen polimorfizmi (rs6265) ile BDNF gen ekspresyon düzeylerinin araştırılması
Karakas, Ümıt; Derici, Didem; Ay, Mustafa Ertan; Özdemir, Gurbet Doğru; Erdal, Mehmet Emin; Çevik, Kenan; Ziblak, Alper; Kenar, Ayse Nur Inci
Amaç: Beyin kaynaklı nörotrofik faktörün (BDNF) genetik, moleküler ve hücresel mekanizmalarının ve bunun nöroplastisite ile ilişkisinin daha iyi anlaşılması, majör depresyonda (MD) yeni ilaçlar için gelecekteki terapötik hedeflerin bulunmasında çok önemli bir rol oynayabilir. Bu çalışma, BDNF polimorfizmlerinin MD'deki kesin rolüne ilişkin hala çelişkili sonuçlar olduğundan, MD'de BDNF ile ilişkili polimorfizm (rs6265) ve ekspresyon ilişkisini anlamak amacıyla planlandı. Yöntem: Bu olgu-kontrol çalışmasında, DSM-5 ölçütlerine göre MD’li 51 hasta ve 75 sağlıklı kontrole ait kanlardan BDNF gen Val66Met (rs6265) polimorfizmleri için dizayn edilmiş primerler ile Real-Time PCR ile tek nükleotid polimorfizm çalışmaları yapıldı. Gen ekspresyon analizleri için total RNA kullanıldı. Kantitatif Real-Time PCR yöntemi ile saptanan, MD ve kontrol gruplarındaki BDNF genine ait ekspresyon düzeyleri ile polimorfizmler arasındaki ilişki istatistiksel yöntemlerle incelendi. Bulgular: Erkek ve kadınlarda, genotip ile grup ve alel frekansı ile grup arasında istatistiksel olarak anlamlı bir ilişki gözlenmemiştir. Alel ile MD arasındaki ilişkide ve genotip ile MD arasında anlamlı bir ilişki olmadığı görülmüştür. Genotip grupları arasında BDNF ekspresyon düzeyleri bakımından istatistiksel olarak anlamlı bir farklılık yoktur. Hem MD grubu hem de kontrol grubu için BDNF’nin polimorfik genotipleri arasında ekspresyon düzeyleri bakımından fark gözlenmemiştir. Sonuç: Çalışma bulguları istatistiksel olarak önemli olmamasına rağmen rapor edilmiş önceki çalışmaların da ışığında BDNF varyantlarının daha derinlemesine analizlerinin, gelecekte farmasötik müdahale ve majör depresyonun hassas tıbbı için olası yeni hedeflere işaret edebileceğini düşünmekteyiz. Ayrıca kişiselleştirilmiş tıp çağında, klinik müdahalelerin etkinliğini etkileyebilecek hem küresel hem de spesifik faktörlerin anlaşılması, tıp alanında önemli ilerlemeler sağlayabilir
- MakaleAçık Erişim2023Hipertansiyon Hastalarının Tanımlayıcı Özellikleri ve Aleksitimi Düzeyleri Öz Etkililik Düzeylerinin Yordayıcısı Mıdır?
Özdemir, Serap Çetinkaya; Metin, Tuba; Semerci, Vahide
Giriş: Hipertansiyon hastalarında kan basıncının kontrol altına alınmasında aleksitiminin yönetilmesi ve öz etkililiğin değerlendirilmesi önemlidir. Amaç: Bu çalışmadaki amaç hipertansiyon hastalarının tanımlayıcı özelliklerinin ve aleksitimi düzeylerinin öz etkililik düzeylerinin yordayıcısı olup olmadığını belirlemektir. Yöntem: Bu araştırma nicel araştırma yönteminin korelasyon desenine göre yapıldı. Araştırmanın verileri Aralık 2022-Mayıs 2023 tarihleri arasında toplandı. Araştırmanın evrenini Türkiye’de yaşayan hipertansiyonlu hastalar oluşturdu ve çalışmaya toplam 103 hipertansiyon hastası katıldı. Araştırmanın verileri “Hasta Tanılama Formu”, “Toronto Aleksitimi Ölçeği” ve “Hipertansiyon Öz-Etkililik Ölçeği” ile toplandı. Veriler bağımsız örneklem t testi, pearson korelasyon ve çoklu linear regresyon analizi ile değerlendirildi. Bulgular: Yaş ortalaması 45.37 ± 17.03 olan hipertansiyon hastalarının %63.1’inin kadın olduğu belirlendi. Hastaların öz-etkililikleri ile aleksitimi düzeyleri arasında istatistiksel olarak anlamlı bir ilişki bulunmadı (r = -0.071, p > .05). Aleksitiminin dışa-dönük düşünme alt boyutu, yaş, ailede hipertansiyon varlığı ve ilaçları düzenli kullanma bağımsız değişkenlerinin hastaların öz-etkililik düzeyleri üzerindeki varyansın %22.7’sini açıkladığı görüldü. Sonuç: Hastaların öz-etkililiği ile aleksitimi düzeyleri arasında ilişki olmadığı görüldü. Aleksitiminin dışa-dönük düşünme alt boyutu, yaş, ailede hipertansiyon varlığı ve ilaçları düzenli kullanma değişkenlerinin hipertansiyon hastalarının öz etkililik düzeylerini yordadığı bulundu. Hastaların öz-etkililiği ile aleksitimi düzeyleri arasında ilişkiyi ve yordayıcı değişkenleri inceleyen daha kapsamlı çalışmaların yapılması önerilir.
AtıfOpenAlex2TR Dizin1İncele - MakaleAçık Erişim2022CYB mtDNA mutations and expression status of genes in the PI3K/AKT/mTOR signaling pathway in patients with schizophrenia
Dirican, Ebubekir; Uzunçakmak, Sevgi Karabulut; Özcan, Halil
Purpose: This study aimed to screen for cytochrome b (CYB) mitochondrial DNA (mtDNA) mutations and analyze the mRNA expressions of genes in the PI3K/AKT/mTOR signaling pathway in patients with schizophrenia. Materials and Methods: In this study, whole blood was obtained from 44 schizophrenic patients and 41 healthy individuals for DNA (patients) and RNA (patients and control) isolation. Samples for CYB mtDNA mutations were amplified by PCR and identified by Sanger DNA sequencing. RT-PCR and 2- increment increment Ct method was used for mRNA expression of PIK3CA, AKT1, and mTOR genes. Results: In schizophrenia patients, m.15326 A > G (43/44), m.15452 C > A (5/44), m.15078 A > G (3/44), m.14872 C > T (3/44) and m.14798 T > C (3/44) was the most common CYB mtDNA mutations. In silico analysis showed that some of the mutations were associated with the harmful, disease-causing or benign character. The mRNA expression of the PIK3CA, AKT1, and mTOR genes in schizophrenia patients was significantly higher than in healthy individuals. There was a significant moderate positive correlation between the PIK3CA and AKT1 genes. In addition, by ROC analysis, PIK3CA, AKT1 and mTOR genes were found to have good diagnostic power in the patient group. ROC analyzes showed that PIK3CA in particular has significant diagnostic value for schizophrenia patients with 80% sensitivity and 63.4% specificity. Conclusion: Both of CYB mtDNA mutations frequency and PIK3CA, AKT1 and mTOR mRNA expression were higher in schizophrenic patients compared to healthy individuals. We believe that studying these mechanisms in
AtıfWoS1OpenAlex1TR Dizin1
İncele - MakaleYalnız künye2021Attacks Based on Insanity in the Context of Forensic Psychiatry in Ottoman Society (1831-1917)
Ozdemir, Gazi
In today's psychiatry literature, the phenomenon of insanity is either incompletely defined or not defined at all. However, in social life, especially in the media, the actions that result in injury or death of people who have brought insanity continue to exist as a sad state of affairs. In this research, the insanity attacks that occurred as a result of a sudden outburst of anger in Ottoman society were discussed. The cases of insanity in the Ottoman society were examined with examples from the dimension of forensic psychiatry. In the scan made on the Ottoman Archive Document Scanning System (BETSIS) of the Presidency of the Republic of Turkey State Archives, 288 insanity cases were detected. Among these, 47 cases between 1831-1917, which were included in the research and resulted in injury or death by people who went insane, were included in the study. In addition to these, the research universe was created by adding two cases of insanity in Avni Mahmud's book titled Muhtasar Emrâz-ı Akliye. Qualitative research method and retrospective/regressive technique were used in this study. The data were evaluated by content analysis. Descriptive analysis of the digitized data was done in Pivot Table. As a result, it was seen that the health checks of the people who went insane in the Ottoman State were taken into account in the name of personal rights and the judicial and administrative order, and these people were sent to the hospital, hospital and Medicine School by the courthouse, police and other institutions. It is understood that in these units, the procedures related to the surveillance, diagnosis and treatment processes are carried out by the specialist physicians in accordance with the legislation in force regarding whether their mental health is in place, and they report the decisions regarding the criminal capacity of the accused and send them to the competent authorities. Among the cases examined, it was determined that 100% of the insanity incidents were carried out by men and that 80 people were harmed in total from 49 insanity attacks.
- MakaleAçık Erişim2020Correlation of IGF-I and IGFBP5 Gene Expression in Schizophrenia Patients
Ozcan, Halil; Karabulut, Sevgi; Yeloğlu, Çağdaş Hünkar
Objective: Schizophrenia is a severe mental disorder affecting more than 21 million people worldwide. Disruptions of the GH-IGF-I axis likely lead to schizophrenia by causing deficits in early stages of neurodevelopment and low IGF-I levels are related to pre/postnatal growth and schizophrenia. IGF axis has effective role on healthy cell growth both prenatal and postnatal. IGF-I function effecting cancer cells is regulated by IGFBP-5. Several studies showed that IGF-I expression is low in schizophrenia patients. Aim of this study is to investigate relation of IGF-I and IGFBP-5 mRNA expression levels in Schizophrenia. Materials and Methods: Fırstly, we collected the serum samples from patients who are diagnosed with schizophrenia and healthy control group. Then RNA was isolated from these serum samples. RNA expression was investigated by real time PCR. Results were evaluated using delta delta Ct. In this study IGF-I and IGFBP5 gene expression levels were calculated. For this purpose a portion of serum taken for routine tests was used. Results: Results of this study showed that there is no significant difference of IGF-I and IGFBP5 gene expression levels between patients and healthy subjects. On the other hand an important negative correlation between IGFBP5 expression level and age was found (p<0,05). Beside that there was not any association between PANNS points and gene expression levels. Conclusion: Consequently, relation of PANSS and gene expressions was not significant. Otherwise IGFBP5 and IGF-I mRNA expression levels had not an important relation for schizophrenia patients.