Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Dertli, Enes(11)
- Hasar, Ugur Cem(8)
- Kaya, Yunus(8)
- Özdemir, Akın(7)
- İspirli, Hümeyra(7)
- Şahin, Engin(7)
- Ertugrul, Mehmet(6)
- Yilmaz, Mustafa Tahsin(6)
- Abdioglu, Murat(4)
- Ozturk, Gokhan(4)
- Ozturk, Hamdullah(4)
- Uçurum, Metin(4)
- Abdioglu, M.(3)
- Cinar, Mehmet(3)
- Ozturk, K.(3)
- Ozturk, U. Kemal(3)
- Taylan, Osman(3)
- Asiri, Abdullah M.(2)
- Banaz, Emrullah(2)
- Bekir, Seyhan(2)
- Beydemir, Şükrü(2)
- Bulbuloglu, Semra(2)
- Can, Zehra(2)
- Can, Özgür Devrim(2)
- Chinna Babu, P.(2)
- Cinar, M.(2)
- Gökçe, H.S.(2)
- Izginli, Mucahit(2)
- Karabacak, M.(2)
- Karabacak, Mehmet(2)
- Korkmaz, Kader(2)
- Kurt, M.(2)
- Makas, Samet(2)
- Manci, Egemen(2)
- Okumus, Halil Ibrahim(2)
- Ozkat, Erkan Caner(2)
- Saricaoglu, Furkan Turker(2)
- Sağdıç, Osman(2)
- Sundaraganesan, N.(2)
- Söyüt, Hakan(2)
Yayınlar
- MakaleYalnız künye2016Scopus SJRQ2In vitro inhibitory effects of palonosetron hydrochloride, bevacizumab and cyclophosphamide on purified paraoxonase-I (hPON1) from human serum
Türkeş, Cüneyt; Söyüt, Hakan; Beydemir, Şükrü
In this study, we investigated the effects of the drugs, palonosetron hydrochloride, bevacizumab and cyclophosphamide, on human serum paraoxonase-I (hPON1) enzyme activity in in vitro conditions. The enzyme was purified ~231-fold with 34.2% yield by using ammonium sulphate precipitation, DEAE-Sephadex A-50 ion-exchange chromatography and Sephadex G-200 gel-filtration chromatography from human serum. hPON1 exhibited a single protein band on the SDS polyacrylamide gel electrophoresis. The inhibition studies were performed on paraoxonase activity of palonosetron hydrochloride, bevacizumab and cyclophosphamide. Ki constants were found as 0.033 ± 0.001, 0.054 ± 0.003 mM and 3.419 ± 0.518 mM, respectively. Compared to the inhibition rates of the drugs, palonosetron hydrochloride has the maximum inhibition rate. However, inhibition mechanisms of the drugs were determined as noncompetitive by Lineweaver-Burk curves.
AtıfScopus49WoS49OpenAlex56
İncele - MakaleAçık Erişim2015Scopus SJRQ1The effect of starch modification and concentration on steady-state and dynamic rheology of meat emulsions
Genccelep, Huseyin; Saricaoglu, Furkan Turker; Anil, Munir; Agar, Berrin; Turhan, Sadettin
In this study, the effect of starch modification (NPS, native potato starch; AMS, acid modified starch; DMS, dextrinized modified starch; PGS, pre-gelatinized modified starch) and its concentrations (1, 2, 4wt%) on steady-state and dynamic rheological properties of meat emulsions were determined. Water-oil binding capacity and intrinsic viscosity of potato starch increased up to 5.07-0.90g/g, and 14.98mL/g, respectively, after modifying with pre-gelatinization method. The particle size of starches as average mean diameter ranged between 44.19μm and 293.06μm. The maximum solubility was obtained from DMS after heat treatment at 70°C being 48.22%, which means an increase about 3.06-fold in solubility as compared with NPS. The Ostwald-de Waele model was successfully used to describe the flow properties of meat emulsions (R2>0.961). While starch types did not affect the K values of emulsions (p>0.05), starch concentrations did (p<0.01). All studied emulsions exhibited non-Newtonian, pseudoplastic behavior since n values were lower than 1. Emulsion systems were characterized as weak gel-like macromolecular dispersions with storage modulus (G') much greater than loss modulus (G″). A modified Cox-Merz rule was applied by multiplying angular frequency with shift factors (αSF). Frequency dependence of complex modulus (G*) was studied to measure the strength of cross-linking protein network of emulsion systems by calculating a constant order of relaxation function (α) and concentration dependent stiffness parameter (Aα). It was concluded that PGS addition improved rheological properties of meat emulsions due to higher solubility, particle size, intrinsic viscosity, water-oil binding capacity than NPS.
AtıfScopus92WoS77OpenAlex92İncele - MakaleYayıncıda açık erişim2015Scopus SJRQ1Monitoring macro voids in mortars by computerized tomography method
Tekin, Ilker; Birgul, Recep; Ozgur Yaman, Ismail; Gencel, Osman; Yilmaz Aruntas, Huseyin
This study aims to investigate the use of ground pumice powder (PP) in cement production and to monitor void developments in mortars by X-ray Computerized Tomography (CT) which is a nondestructive test method. PP-blended cements were produced by replacing ordinary Portland cement with PP at 0% (control), 5%, 10% and 15% by weight. Paste and mortar specimens were manufactured by these blended cements. Some of the physical and mechanical tests are carried out on these mortar specimens. Experimental results showed that macro void developments in 100-day period for mortars with different PP replacement ratios exhibited different reduction in void ratios.
AtıfScopus19WoS17OpenAlex19İncele - MakaleYalnız künye2015Scopus SJRQ1An experimental and density functional study on conformational and spectroscopic analysis of 5-methoxyindole-2-carboxylic acid
Cinar, Mehmet; Karabacak, Mehmet; Asiri, Abdullah M.
In this article, a brief conformational and spectroscopic characterization of 5-methoxyindole-2-carboxylic acid (5-MeOICA) via experimental techniques and applications of quantum chemical methods is presented. The conformational analysis of the studied molecule was determined theoretically using density functional computations for ground state, and compared with previously reported experimental findings. The vibrational transitions were examined by measured FT-IR and FT-Raman spectroscopic data, and also results obtained from B3LYP and CAM-B3LYP functionals in combination with 6-311++G(d,p) basis set. The recorded proton and carbon NMR spectra in DMSO solution were analyzed to obtain the exact conformation. Due to intermolecular hydrogen bondings, NMR calculations were performed for the dimeric form of 5-MeOICA and so chemical shifts of those protons were predicted more accurately. Finally, electronic properties of steady compound were identified by a comparative study of UV absorption spectra in ethanol and water solution and TD-DFT calculations.
AtıfScopus23WoS22OpenAlex24İncele - MakaleAçık Erişim2015Scopus SJRQ1Using solar greenhouses in cold climates and evaluating optimum type according to sizing, position and location: A case study
Çakir, Uğur; Şahin, Erol
This study deals with a comparison among five common greenhouse types with regard to total solar radiation gaining rates in greenhouse using season under some assumptions. Additionally, possibility of using greenhouses in cold climate regions is investigated. We analyzed five greenhouse types and developed a script in MATLAB platform for the solar radiation availability. This model is applicable and suitable for other buildings and places on the world. Even-span, uneven-span, vinery, semicircular and elliptic types of greenhouses have been analyzed. A "k" value (ratio of length to width of greenhouse) and greenhouse azimuth angle (GAA) are described. Seven different floor area are assigned for each greenhouse type such as 50m2, 100m2, 150m2, 200m2, 250m2, 300m2 and 400m2, respectively. For each floor area, k value is assigned from 1 to 10. Each greenhouse is oriented in 90 different angles according to south facade. Seasonal total solar energy gaining rates is computed individually for all possible greenhouse types, area, k number and orientation. Then a comprehensive comparison is made to determine the optimal greenhouse. The results show that greenhouses are usable and suitable for using in cold climate regions to increase the productivity. In addition, the elliptic type is the optimum one in all analyzed types of greenhouses for Bayburt conditions for all floor areas. It is followed by uneven-span, even-span, semi-circular and vinery type of greenhouses respectively. Shape and type of the roof are main effective parameters on solar energy gaining rates of greenhouses. Elliptic greenhouse should be preferred on the band of the latitude of Bayburt, unless there is restrictive factor like sizing and terrain.
AtıfScopus93WoS77OpenAlex95İncele - BildiriYalnız künye2014Scopus SJRQ1ZnO thin film synthesis by reactive radio frequency magnetron sputtering
Şenay, Volkan; Pat, Suat; Korkmaz, Şadan; Aydoʇmuş, Tuna; Elmas, Saliha; Özen, Soner; Ekem, Naci; Balbaʇ, M. Zafer
In this study, ZnO thin films were deposited on glass substrates by reactive RF magnetron sputtering method at argon-oxygen gas mixing (1:1) atmosphere. Some properties of the synthesized films were investigated by interferometry, UV-vis spectrophotometer, atomic force microscopy, and tensiometer. Tauc method was adopted to estimate the optical band gaps. The band gaps of the deposited films were affected by film thickness. We concluded that the surface composition plays a substantial role in the values of the band gaps. Nanocrystalline structures were detected in all produced samples.
AtıfScopus55WoS49İncele - MakaleAçık Erişim2014Scopus SJRQ2Effect of calcium channel blockers on paraoxonase-1 (PON1) activity and oxidative stress
Türkeş, Cüneyt; Söyüt, Hakan; Beydemir, Şükrü
Background: In this study, we investigated the in vitro effects of calcium channel blockers (nifedipine, nitrendipine, isradipine, and amlodipine besylate) on the activity of paraoxonase-1 (PON1). Methods: PON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion-exchange and Sephadex G-200 gel filtration chromatography. Results: The calcium channel blockers decreased the in vitro PON1 activity. The inhibition mechanism of amlodipine besylate was noncompetitive, whereas nifedipine, nitrendipine, and isradipine were competitive inhibitors. Conclusions: Our results showed that calcium channel blockers exhibit inhibitory effects on PON1 at low concentrations. The IC50 values for nifedipine, nitrendipine, isradipine, and amlodipine besylate were determined to be 0.121 mM, 0.130 mM, 0.255 mM, and 0.304 mM, respectively, and the Ki constants were calculated to be 0.222 ± 0.049 mM, 0.151 ± 0.067 mM, 0.286 ± 0.137 mM, and 0.321 ± 0.002 mM, respectively.
AtıfScopus68WoS67OpenAlex74İncele - MakaleYalnız künye2013Scopus SJRQ2The infrared, Raman, NMR and UV spectra, ab initio calculations and spectral assignments of 2-amino-4-chloro-6-methoxypyrimidine
Cinar, Z.; Karabacak, M.; Cinar, M.; Kurt, M.; Chinna Babu, P.; Sundaraganesan, N.
(Graph Presented) The 2-amino-4-chloro-6-methoxypyrimidine abbreviated as ACMP have been investigated by both the experimental and theoretical methods; through this work we provide the essential fact about the structural and vibrational insights. The optimized molecular structure, atomic charges, vibrational frequencies and ultraviolet spectral interpretation of ACMP have been studied by performing DFT/B3LYP/6-311++G(df,pd) level of theory. The FT-IR, FT-Raman spectra were recorded in the region 4000-400 cm -1 and 4000-50 cm-1 respectively. The UV absorption spectrum of the compound that dissolved in ethanol and water solution were recorded in the range of 200-400 nm. The scaled wavenumbers are compared with the experimental values. The difference between the observed and scaled wavenumber values of most of the fundamentals is very small. Based on the UV spectrum and TD-DFT calculations, the electronic structure and the assignments of the absorption bands were carried out. The 1H, 13C and DEPT 135 nuclear magnetic resonance (NMR) chemical shifts of the molecule were calculated using with the Gauge Including Atomic Orbital (GIAO) method and compared with experimental results. Besides, molecular electrostatic potential (MEP), frontier molecular orbitals (FMO) analysis were investigated using theoretical calculations.
AtıfScopus11WoS10OpenAlex11İncele - MakaleAçık Erişim2013Scopus SJRQ1Reference-plane invariant transmission-reflection method for measurement of constitutive parameters of liquid materials
Hasar, Ugur Cem; Barroso, Joaquim José; Kaya, Yunus; Ertugrul, Mehmet; Bute, Musa
We propose a new transmission-reflection method for measuring constitutive parameters of liquid samples inside an asymmetric measurement cell (a sample over a low-loss holder in vertical position inside an empty waveguide section). We derived reference-plane invariant expressions for constitutive parameters measurement of liquid samples from reference-plane dependent scattering parameters. In addition, we also applied a simple approach for unique determination of transformation factor and reference-plane distances. After, we also investigated how the performance of the proposed method could be improved by performing a differential uncertainty analysis. From this analysis, we found the following key results: (a) the accuracy of the proposed method could be enhanced for low-loss liquid samples by using thicker samples, and (b) the effect of constitutive parameters and the length of the (low-loss) sample holder on constitutive parameters measurements of liquid samples by the proposed method is a key parameter in increasing the accuracy of the measurements. Finally, we performed constitutive parameter measurements of distilled water and methanol to validate the proposed method and compared the proposed method with similar methods in the literature. From the measurements, we note that our method is especially useful for liquid sample measurements when the reference-plane transformation factors are not known a priori and/or if the measurements are carried out over a high frequency range.
AtıfScopus20WoS19OpenAlex22İncele - MakaleYalnız künye2013Scopus SJRQ2Experimental and theoretical FTiR and FT-Raman spectroscopic analysis of 1-pyrenecarboxylic acid
Karabacak, M.; Cinar, M.; Kurt, M.; Chinna Babu, P.; Sundaraganesan, N.
The title molecule 1-pyrenecarboxylic acid (1PCA) has been characterized by FTiR, FT-Raman, NMR and UV-Vis spectral analyses. The molecular geometry, harmonic vibrational modes, the corresponding wavenumbers and iR intensities of 1PCA were calculated by DFT method with 6-311G(d, p) basis set. The assignments of the fundamentals were proposed on the basis of total energy distribution (TED) calculations. The calculated 13C and 1H NMR chemical shifts using gauge including atomic orbitals (GiAOs) approach are in good agreement with the observed chemical shifts. The polarizability and first order hyperpolarizability of the title molecule were calculated and interpreted. Using TD-DFT method, the electronic transitions have been compared with the experimental wavelengths. The molecular electrostatic potential map was used for prediction of possible hydrogen and oxygen bonding sites 1PCA molecule.
AtıfScopus45WoS43OpenAlex46İncele - MakaleAçık Erişim2013Scopus SJRQ2An experimental and theoretical investigation of Acenaphthene-5-boronic acid: Conformational study, NBO and NLO analysis, molecular structure and FT-IR, FT-Raman, NMR and UV spectra
Karabacak, Mehmet; Sinha, Leena; Prasad, Onkar; Asiri, Abdullah M.; Cinar, Mehmet
The solid state Fourier transform infrared (FT-IR) and FT-Raman spectra of Acenaphthene-5-boronic acid (AN-5-BA), have been recorded in the range 4000-400 cm1 and 4000-10 cm 1, respectively. Density functional theory (DFT), with the B3LYP functional was used for the optimization of the ground state geometry and simulation of the infrared and Raman spectra of the molecule. The vibrational wave numbers and their assignments were examined theoretically using the Gaussian 09 set of quantum chemistry codes and the normal modes were assigned by a scaled quantum mechanical (SQM) force field approach. Hydrogen-bonded dimer of AN-5-BA, optimized by counterpoise correction, has also been studied by B3LYP at the 6-311++G(d,p) level and the effects of molecular association through O-H·O hydrogen bonding have been discussed. The 1H and 13C nuclear magnetic resonance (NMR) chemical shifts of the molecule were calculated by Gauge-Including Atomic Orbital (GIAO) method. Natural bond orbital (NBO) analysis has been applied to study stability of the molecule arising from charge delocalization. UV spectrum of the title compound was also recorded and the electronic properties, such as frontier orbitals, and band gap energies were measured by TD-DFT approach. The first order hyperpolarizability (β), its components and associated properties such as average polarizability and anisotropy of the polarizability (α and Δα) of AN-5-BA was calculated using the finite-field approach.
AtıfScopus38WoS36OpenAlex33İncele - MakaleAçık Erişim2012Scopus SJRQ1Effect of ultrasound treatment on steady and dynamic shear properties of glucomannan based salep dispersions: Optimization of amplitude level, sonication time and temperature using response surface methodology
Karaman, Safa; Yilmaz, Mustafa Tahsin; Ertugay, Mustafa Fatih; Baslar, Mehmet; Kayacier, Ahmed
The present study investigated effect of different amplitude levels (40, 70 and 100%), sonication temperatures (40, 50 and 60 °C) and exposure times (3, 7 and 11 min) on steady shear properties; apparent viscosity (η), shear stress (σ), consistency coefficient (K), flow behavior index (n) and dynamic shear properties; storage modulus (G′), loss modulus (G″), complex viscosity (η), complex modulus (G) and loss tangent (tan δ) values of glucomannan based salep solution (SS) and salep drink (SD) samples. In addition, the steady and dynamic shear properties were optimized using ridge analysis in terms of amplitude level, sonication temperature and exposure times levels. Increasing amplitude level and sonication time decreased considerably the η, σ, K, G′, G″ and η values of salep dispersions (SS and SD samples). However, sonication temperature did not have a remarkable effect on these properties.
AtıfScopus40WoS36OpenAlex42İncele - DergiApplied Surface Science
- DergiPharmacological Reports
- DergiSensors and Actuators, A: Physical
- DergiSwarm and Evolutionary Computation
- DergiEnvironmental Nanotechnology, Monitoring and Management
- DergiPhysica B: Condensed Matter
- DergiBiochemical and Biophysical Research Communications
- DergiPhysica A: Statistical Mechanics and its Applications