Bayburt Üniversitesi

Ongan, Serdar; Kuziboev, Bekhzod; Makhmudov, Samariddin; Matyakubova, Aziza; Imamoglu, Ilyas Kays; Aydin, Rahman; Isik, Cem

Energy vulnerability is a critical concern for achieving energy security and meeting the SDGs. However, the role of economic complexity, which represents a country's production and export diversification, in energy vulnerability has been largely neglected in the literature. This study fills this gap by examining the impact of economic complexity on energy vulnerability for 69 developing countries over the period 2000-2019. For this purpose, MMQR and various instrumental variable (IV) estimation techniques (IV-Quantile, 2SLS, Lewbel, and Kiviet) were used. In addition, ESG indicators were included in the model as instrumental variables to address potential endogeneity issues between economic complexity and energy vulnerability. In doing so, the ESG indicators are also included in the model as instrumental variables to control for the endogeneity of economic complexity. Empirical findings show that economic complexity is associated with lower energy vulnerability across all quantiles. These results reveal that countries with diversified economic structures (higher economic complexity) may be more resilient to energy shocks. Therefore, developing countries should focus on structural reforms and improve their ESG performances to reduce energy vulnerability. In terms of control variables, financial development, digitalization, and human capital are associated with lower energy vulnerability, whereas increases in natural resource revenues are sometimes associated with lower vulnerability levels. This finding suggests that, in the context of energy vulnerability, the predictions of the resource curse theory may not be observed in every case.

İncele

Bulgay, Celal; Kasakolu, Anil; Kazan, Hasan Hueseyin; Mijaica, Raluca; Zorba, Erdal; Akman, Onur; Bayraktar, Isik; Ekmekci, Ridvan; Koncagul, Seyrani; Ulucan, Korkut

The aim of the study was to identify genetic variants associated with personal best scores in Turkish track and field athletes and to compare allelic frequencies between sprint/power and endurance athletes and controls using a whole-exome sequencing (WES) approach, followed by replication studies in independent cohorts. The discovery phase involved 60 elite Turkish athletes (31 sprint/power and 29 endurance) and 20 ethnically matched controls. The replication phase involved 1132 individuals (115 elite Russian sprinters, 373 elite Russian endurance athletes (of which 75 athletes were with VO2max measurements), 209 controls, 148 Russian and 287 Finnish individuals with muscle fiber composition and cross-sectional area (CSA) data). None of the single nucleotide polymorphisms (SNPs) reached an exome-wide significance level (p < 2.3 x 10(-7)) in genotype-phenotype and case-control studies of Turkish athletes. However, of the 53 nominally (p < 0.05) associated SNPs, four functional variants were replicated. The SIRT1 rs41299232 G allele was significantly over-represented in Turkish (p = 0.047) and Russian (p = 0.018) endurance athletes compared to sprint/power athletes and was associated with increased VO2max (p = 0.037) and a greater proportion of slow-twitch muscle fibers (p = 0.035). The NUP210 rs2280084 A allele was significantly over-represented in Turkish (p = 0.044) and Russian (p = 0.012) endurance athletes compared to sprint/power athletes. The TRPM2 rs1785440 G allele was significantly over-represented in Turkish endurance athletes compared to sprint/power athletes (p = 0.034) and was associated with increased VO2max (p = 0.008). The AGRN rs4074992 C allele was significantly over-represented in Turkish sprint/power athletes compared to endurance athletes (p = 0.037) and was associated with a greater CSA of fast-twitch muscle fibers (p = 0.024). In conclusion, we present the first WES study of athletes showing that this approach can be used to identify novel genetic markers associated with exercise- and sport-related phenotypes.

AtıfWoS23

İncele

Custódio, Luisa; Vizetto-Duarte, Catarina; Cebeci, Fatma; Özçelik, Beraat; Sharopov, Farukh; Gürer, Eda Sonmez; Kumar, Manoj; Iriti, Marcello; Sharifi-Rad, Javad; Calina, Daniela

Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.

AtıfWoS10

İncele

Salehi, Bahare; Rescigno, Antonio; Dettori, Tinuccia; Calina, Daniela; Docea, Anca Oana; Singh, Laxman; Cebeci, Fatma; Özçelik, Beraat; Bhia, Mohammed; Dowlati Beirami, Amirreza

Avocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g., morphea, sclerodactyly, scleroderma in bands). Besides, it was reported that it can improve the mood and quality of life of postmenopausal women in reducing menopause-related symptoms. This article aims to summarize the studies on biological effects of the avocado-soybean unsaponifiable, its chemical composition, pharmacotherapy as well as applications in autoimmune, osteoarticular and menopausal disorders. Finally, we will also discuss on its safety, toxicological and regulatory practices.

AtıfWoS80

İncele

Isik, Cem; Ongan, Serdar; Isik, Olcay; Aydin, Rahman; Imamoglu, Ilyas Kays

Business freedom (FR) and women's labor law (WLL) are critical in achieving the SDGs. This research aims to test the effect of these two factors on the SDGs while also considering economic growth and energy efficiency, framing the analysis within the legal, economic, and environmental dynamics of the SDGs holistically. Fourier-augmented PANIC, cross-sectional dependence tests, panel OLS, bootstrap quantile regression, and panel Granger causality tests are applied for this aim. The OLS and bootstrap quantile regression analyses indicate that while FR negatively affects SDG at lower quantiles, these effects turn positive in higher quantiles. This can mean that in countries with high institutional quality, the freedom to do business becomes a tool for supporting sustainable economic development. The WLL has positive effects on SDGs in all quantiles except the 20th quantile. This result clearly shows the decisive role of women's labor rights and legal protections in driving sustainable development. The Granger causality test also supports these results: FR and WLL have a positive Granger causality effect on the SDGs. Additionally, while GDP positively affects SDGs in all quantiles, renewable energy efficiency negatively affects SDGs at low quantiles and has a positive impact at higher quantiles.

AtıfWoS11

İncele

Isik, Cem; Ongan, Serdar; Kuziboev, Bekhzod; Imamoglu, Ilyas Kays; Amin, Azka

This study investigates the impact of corporate social responsibility (CSR) on energy security (ENSEC) for 34 developed countries. It offers a new institutional perspective by linking CSR to ENSEC within the framework of sustainable development. MMQR, PLFC, and DID methods are used for this analysis. The MMQR results indicate that CSR enhances ENSEC across all percentiles (10%-90%) in both aggregate and disaggregated analyses, across the social, environmental, and governance dimensions. Moreover, the PLFC model's findings reveal that CSR promotes ENSEC in aggregate, regardless of income level. However, in the disaggregated estimates from the PLFC model, the social dimension of CSR has no effect on ENSEC, whereas the environmental and governance dimensions continue to have a positive effect on ENSEC. As for the impact of China's energy investment, only China's fossil energy investment ensures ENSEC. These findings provide important policy insights by empirically validating the role of CSR in addressing long-term energy risks.

AtıfWoS1

İncele