İlgi alanları

• MakaleYalnız künye2026Scopus SJRQ2/r/bayburt/10789
  Comprehensive characterization of 26 Turkish asteraceae species: Insights from FTIR, phytochemical composition, and elemental analysis via ICP-MS

  Civas, Ayse; Karakas, Seydanur; Bayrak, Burak; Akyüz, Beyzanur; Keçeci, Emire Bengisu; Özerd, Elif Beyza; Sönmez, Hatice Rumeysa; Asgarli, Tugay; Disli, Fatma Taeb; Yuca, Hafize

  This study provides a comprehensive phytochemical, elemental, and spectroscopic characterization of 26 species belonging to the Asteraceae family, several of which are endemic to T & uuml;rkiye and traditionally used in folk medicine. Qualitative screening revealed the widespread presence of flavonoids, saponins, tannins, and carbohydrates, while alkaloids and anthracene heterosides were entirely absent in all taxa. Among the species analyzed, Cichorium intybus, Cyanus depressus, Achillea arabica, and Cirsium davisianum exhibited the richest phytochemical diversity, suggesting strong biological potential. Quantitative evaluation showed that Klasea serratuloides possessed the highest total phenolic content (99.49 mu g GAE/mg extract), followed by Artemisia scoparia and Inula sarana, indicating notable antioxidant potential. Elemental analysis by ICP-MS demonstrated significant interspecies variation, with Centaurea armena, Centaurea arvensis, and Cichorium intybus containing elevated levels of essential macro- and trace elements such as K, Mg, Ca, Zn, and Se, whereas Helichrysum plicatum and Scorzonera ulrichii showed high Co and Se contents. Conversely, trace levels of potentially toxic elements (e.g., Al, U) were detected in some taxa, emphasizing the need for careful evaluation of their pharmacological use. FTIR analysis confirmed the presence of functional groups characteristic of phenolics, flavonoids, tannins, coumarins, and cardioactive heterosides, as indicated by distinct O-H (3200-3600 cm-1), C-H (2850-2950 cm-1), and C=O (1700-1650 cm-1) stretching bands. The combined interpretation of phytochemical and FTIR data underscores the chemical diversity and functional group complexity of these plant extracts. Overall, the results highlight the nutritional and pharmacognostic significance of several Asteraceae species, supporting their potential application in antioxidant, nutraceutical, and therapeutic formulations.

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• MakaleYayıncıda açık erişim2026/r/bayburt/12720
  Bioactive profile and mineral composition of fruit extracts from four wild hawthorn (Crataegus spp.) species

  Çakır, Özlem; Çınar Topçu, Kübra; Sefali, Abdurrahman; Bayyiğit, İshak; İlhan, Gülçe; Singh, Jyoti

  This study compared the antioxidant capacity, total phenolic content (TPC), phenolic composition, lipid oxidation level, and mineral profiles of extracts obtained from four wild hawthorn species (Crataegus tanacetifolia, C. orientalis subsp. orientalis, C. orientalis subsp. szovitsii, and C. monogyna) collected from northeastern Türkiye. Significant interspecific variations were observed in DPPH, FRAP, and CUPRAC assays. While C. monogyna had the highest reducing capacity and TPC, C. orientalis subsp. szovitsii had the highest DPPH activity. Ultra-high performance liquid chromatography coupled to tandem mass spectrometry analysis showed that catechin, epicatechin, chlorogenic acid, and quinic acid were the major phenolics, and were particularly abundant in C. monogyna. Despite having a high phenolic content, C. monogyna had the highest malondialdehyde level, indicating that phenolics alone were insufficient to fully inhibit lipid oxidation. Inductively coupled plasma-mass spectrometry mineral analysis detected high levels of K, Mg, and P in all species. Principal component analysis effectively distinguished the species based on their antioxidant, phenolic, and mineral profiles. Overall, hawthorn fruits were confirmed as valuable sources of natural antioxidants and essential minerals.

  AtıfScopus1·WoS1

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• MakaleYayıncıda açık erişim2026/r/bayburt/11392
  ANDROSACE ARMENIACA SUBSP. VULCANICA SEFALI & EROĞLU: A NEW TAXON FROM EASTERN ANATOLIA, TÜRKIYE

  Sefali, Abdurrahman; Korkmaz, Eren; Eroğlu, Hüseyin

  A new taxa, Androsace armeniaca subsp. vulcanica Sefalı & Eroğlu nov. (Primulaceae) is described and illustrated from Ağrı Province, Türkiye. It is morphologically assigned to Androsace sect. Andrapsis based on its long scape and small flower habit and the presence of glandular hairs covering the calyx and scape. This new taxon closely resembles A. armeniaca subsp. armeniaca var. armeniaca and A. armeniaca subsp. armeniaca var. macrantha, but is easily distinguished by its overall habitus, smaller flowers, distinct corolla and calyx characteristics (including the color and lobe shape), pedicel length and habitat (volcanic areas).

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• MakaleYayıncıda açık erişim2026/r/bayburt/11293
  Chemical Profiling of Stachys cretica subsp. anatolica Rech. f. (Endemic) Essential Oils and their Methanol Extracts with Evaluation as Enzyme Inhibitors, Antioxidant, and Antimicrobial Agents

  Öz, Mehmet; Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman; Aygül, İmdat

  Enzyme inhibition activities, phenolic compounds, antioxidant activities, bioactive compounds, antimicrobial activities, and chemical components of essential oil and methanol extracts obtained from the aerial parts of S. cretica subsp. anatolica were investigated. The main phenolic compounds of aerial parts were catechin, oleuropein, and epicatechin. The determined enzyme inhibitor activities highlight the potential of S. cretica subsp. anatolica as a source of bioactive compounds, particularly for carbonic anhydrase and cholinesterase inhibition. The essential oil and methanol extract exhibited remarkable activities against CA-II, AChE, and BChE, although they were less potent than standard inhibitors. The essential oils generally showed stronger antimicrobial activity compared to the 30% methanol extracts across most bacterial and fungal strains, as evidenced by minimum lethal concentration (MLC) and lower minimum inhibitory concentration (MIC) values and larger inhibition zones. Chloramphenicol used alone exhibited the highest antimicrobial efficacy, with the lowest MIC and MLC values and the largest inhibition zones. The essential oils of S. cretica subsp. anatolica were determined as esters, oxygenated sesquiterpenes, and aldehydes in aerial parts. The main components were found to be hexahydrofarnesyl acetone in the aerial parts.

  AtıfScopus3·WoS3

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• MakaleYayıncıda açık erişim2026/r/bayburt/10921
  Chemical Profiling and Biological Activities of Methanol Extracts and Essential Oils From Ferulago Platycarpa Boiss. & Balansa (Endemic): Enzyme Inhibition, Antioxidant, and Antimicrobial Properties

  Aygül, İmdat; Öz, Mehmet; Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman

  This study aimed to evaluate the phytochemical composition and biological activities of Ferulago platycarpa methanol extract (ME) and essential oil (EO). The EO was obtained via hydrodistillation and analyzed by GC-MS, revealing sesquiterpene hydrocarbons as the dominant class, with caryophyllene (65.8%) and α-pinene (9.65%) as the major constituents. The methanol extract was subjected to LC-MS/MS analysis, which identified eleven phenolic compounds, with chlorogenic acid as the most abundant. The extract showed significantly higher total phenolic (1196.22±11.64 mg GAE/100g) and antioxidant (1870.00±17.69 mg QEE/100g) contents compared to the ME. In vitro enzyme inhibition assays demonstrated that the methanol extract exhibited potent inhibitory activity against carbonic anhydrase II (CA-II, ICSO= 0.023 pg/mL), acetylcholinesterase (AChE, ICSO= 110 pg/mL), and butyrylcholinesterase (BChE, IC50= 390 pg/mL). In contrast, the EO showed higher inhibition against α-amylase (IC50= 5920±10.45 pg/mL) and BChE (IC50= 1.32±0.65 pg/mL), while its α-glucosidase showed no inhibition. Antioxidant assays indicated superior activity for the methanol extract compared to the EO. Furthermore, antimicrobial testing revealed that the EO demonstrated broader and more effective antimicrobial action, exhibiting lower MIC and MBC values against several bacterial and fungal strains. Collectively, these results highlight F. platycarpa as a valuable source of bioactive compounds with promising applications in antidiabetic, neuroprotective, antioxidant, and antimicrobial therapies.

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• MakaleYayıncıda açık erişim2025/r/bayburt/12871
  Primula longipes subsp. bayburtensis Sefali, Yapar & Demir (Primulaceae): A new taxon from north-eastern Anatolia, Türkiye

  Sefalı, Abdurrahman; Yapar, Yakup; Demir, İbrahim; Yurtvermez, Bayram; Keser, Ali Murat

  The new taxon, Primula longipes subsp. bayburtensis Sefali, Yapar & Demir, subsp. nov. (Primulaceae) is described and illustrated from Bayburt Province, Türkiye. It is morphologically assigned to Primula sect. Crystallophlomis based on its long scapes, lanceolate and denticulate leaf with long petiole and hairless habit, fruits longer than calyx and covered by farina on the scape. This new taxon is similar to Primula longipes and P. nivalis subsp. turkestanica; it can also be easily distinguished by its calyx divided ratio, thurm flowers (unwidened corolla tube shape and length) and capsules (length) futures.

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• MakaleYayıncıda açık erişim2025/r/bayburt/11799
  Chemical composition of essential oils and comparative analysis of enzyme inhibitory, antioxidant and antimicrobial activities in essential oils of endemic Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N. Kilian

  Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman; Aygül, İmdat; Öz, Mehmet

  In this study, essential oil from the aerial parts of Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N. Kilian was extracted via hydrodistillation using a Clevenger apparatus. GC-MS/FID analysis determined aldehydes (28.31%) as the dominant group, with eucalyptol (8.71%) as the main constituent. Antioxidant activities were exhibited using DPPH, ABTS, and FRAP assays, with the essential oil demonstrating relatively higher antioxidant properties. The essential oil also showed higher levels of bioactive components, including total antioxidant capacity (160.26 mg AA eq./100 mL), total phenolic content (21.57 mg GA eq./100 mL), and total flavonoid content (14.85 mg QE eq./100 mL). While G. sericea essential oil demonstrated some antioxidant activity, it was significantly lower compared to the reference standard ascorbic acid (AA). The antimicrobial results showed relatively higher antimicrobial activity compared to most bacterial and fungal strains, as evidenced by lower MIC and MBC values and larger inhibition zones. Nevertheless, chloramphenicol (CH) and nalidixic acid (NA) continually showed superior antimicrobial efficacy, with the lowest MIC and MBC values and the largest inhibition zones. The essential oil also demonstrated potent enzyme inhibitory activity, especially against CA-II, AChE, and BChE, with the lowest IC50 value observed for CA-II, highlighting its potential as a potent enzyme inhibitor. However, the essential oil exhibited comparatively greater inhibition against AChE, BChE and α-amylase but was less effective overall. These findings suggest that the G. sericea essential oil has important antioxidant potential and enzyme inhibitory activity, while the essential oil shows varying efficacy across different enzymes.

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• MakaleYalnız künye2025/r/bayburt/11648
  Phytochemical analysis and biological evaluation of essential oils and extracts from Heracleum pastinacifolium subsp. incanum (Boiss. & A.Huet) P.H.Davis, an endemic plant from Turkey

  Yuca, Hafize; Sefalı, Abdurrahman; Aydın, Bilge; Karadayı, Mehmet; Gülşahin, Yusuf; Yazıcı, Ayşenur; Karakaya, Songül; Demirci, Betül; Çoban, Furkan; Özdemir, Erkan

  Essential oil content of and phenolic compounds flower-fruit, root, and aerial parts of Heracleum pastinacifolium subsp. incanum were analysed by GC/MS and LC/MS methods, respectively. Antidiabetic, anticholinesterase, and antioxidant activities of flower-fruit, root, aerial parts methanol extracts were evaluated. Apiole (35.0%), myristicine (72.2%), and myristicine (15.1%) were found as major compounds of fruit-flower mixture, root, aerial part essential oils, respectively. Hesperidin was found the highest amount in aerial part and flower-fruit extracts with 8904.2621 ng/mL and 11558.3634 ng/mL values, respectively. Fruit-flower extract showed the highest activity against α-glucosidase (24%). Root extract demonstrating the highest activity (18%) against AChE enzyme. Flowers-fruits mixture methanol extract had a higher % inhibition value on ABTS·+ and DPPH•. Flowers-fruits mixture methanol extract was rich in total phenol, total tannin, and protein content. All the extracts were determined as genetoxically safe according to the results of Ames/Salmonella, Escherichia coli WP2 and Allium cepa assays.

  AtıfScopus1·WoS2

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• MakaleYayıncıda açık erişim2025/r/bayburt/11364
  Enzyme inhibitory, antioxidant, antimicrobial activities, and phenolic profiles of the methanol extract of Gelasia sericea an endemic species

  AYGÜL, İmdat; AKMEŞE, Osman; SEFALI, Abdurrahman; BALTACI, Cemalettin; ÖZ, Mehmet; FIDAN, Muhammed Said

  This study aimed to investigate, for the first time, the phytochemical composition, antioxidant, antimicrobial, and enzyme inhibitory properties of the methanolic extract of Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N.Kilian. The extract demonstrated a moderate yield (6.55 g/100 g dry plant material) and was found to be rich in phenolic acids, particularly ferulic acid (17182.97 μg g-1), followed by caffeic acid, protocatechuic acid, and p-coumaric acid. Antioxidant analyses revealed high total phenolic (388.86 mg GA eq./100 g), total flavonoid (74.03 mg QE eq./100 g), and total antioxidant capacity (503.33 mg AA eq./100 g). The extract exhibited remarkable ABTS radical scavenging activity (95.99%, IC50 = 37.59 mg ml-1) and considerable ferric-ion reducing power (974.78 mg FeSO4 eq./100 g). Antimicrobial assays indicated moderate inhibitory effects, with stronger activity against Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis) and the yeast Candida albicans, whereas Gram-negative bacteria were less susceptible. The extract’s MIC values ranged between 0.20-3.25 mg ml-1, and MLC values between 0.41-6.50 mg ml-1, which were higher than those of standard antibiotics. Enzyme inhibition assays revealed moderate activity against carbonic anhydrase II (IC50 = 0.0136 µg ml-1) and weak inhibition of cholinesterases and α-glucosidase, while α-amylase inhibition was relatively more pronounced (IC50 = 13350.00 µg ml-1). Overall, these findings highlight G. sericea as a valuable natural source of phenolic acids and antioxidants, with promising potential for applications in functional foods, nutraceuticals, and phytopharmaceuticals. However, the relatively limited antimicrobial and enzyme inhibitory activities suggest the need for further studies on bioavailability, in vivo efficacy, and compound isolation to optimize its practical applications.

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• MakaleYalnız künye2024/r/bayburt/13081
  A comparative anatomical study on leaf and scape of Androsace taxa (Primulaceae): contribution to Androsace taxonomy

  Ulcay, Sibel; Sefali, Abdurahman; Yapar, Yakup; Demir, İbrahim; Gıdık, Betül

  In the present study, the leaf and scape anatomical features of ten Androsace taxa distributed in Türkiye were defined to contribute to plant identification. Hand sections from both the scape and leaf examined 43 anatomical characters. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were performed for the first time for Androsace. The results show that there are differences as well as similarities between Androsace species. It is noteworthy that Androsace artvinensis forms a separate main group with HCA. In addition, the fact that two of the five basic components are represented by a single variable according to the PCA results suggests that the anatomical characters examined are determinative for Androsace taxa.). In PCA, eigenvalues of PC1 (2.435), PC2 (1.749), PC3 (1.369), PC4 (1.223), and PC5 (1.006) were greater than 1.0. Cortex width, aerenchyma, arrangement of vascular bundles, and four-branched non-glandular hairs are among the important anatomical characteristics of the scape. Leaf cross-sectional shape, epidermis dimensions, glandular hair types, presence of five branched non-glandular hairs, stoma sizes, presence of crystals in the mesophyll, and types are among the qualitative and quantitative anatomical characteristics that attract attention in the leaf. This study examined almost all taxa of the genus Androsace distributed in Türkiye. The results will be important in finding new species among the examined taxa and revealing the anatomical features of the taxa for the first time. They will contribute to other studies on the genus.

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