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Araştırmacılar(8)

• Bülbül, Ali Savaş
• Camuzcuoğlu, Murat
• Can, Zehra
• Cengiz, Ibrahim
• Çınar, Öznur
• Kul, Sinan
• Özdemir, Mustafa
• Yıldırım, Ümit

• MakaleAçık Erişim2026/r/bayburt/16058
  Comparative evaluation of antioxidant activity and phenolic content of Lupinus albus L. (white bitter lupin, termiye) grown in different regions of Türkiye by RP-HPLC-PDA

  Kara, Yakup; Can, Zehra

  Lupinus albus L. (white bitter lupin) is an important legume species widely cultivated in the Mediterranean region. This study aimed to comparatively evaluate the antioxidant capacity and phenolic composition of L. albus samples collected from different regions of Türkiye. Samples were obtained from Konya (Centre, Akşehir, Doğanhisar), Isparta (Central), and Burdur (Central). Total phenolic content, total flavonoid content and antioxidant activities of samples were determined using FRAP and DPPH assays. Additionally, the qualitative and quantitative profiles of phenolic compounds were analyzed by RP-HPLC-PDA. The total phenolic content was determined to be in the range of 1.96–2.47 mg GAE/g, whereas flavonoids were not detected in any of the samples. The results demonstrated that Lupinus albus L. extracts exhibited notable antioxidant activity, with FRAP values ranging from 1.14 to 1.95 μmol Fe²⁺/g and DPPH (SC₅₀) values ranging from 37.98 to 56.60. The phenolic composition analysis revealed the presence of major compounds including p-hydroxybenzoic acid, p-coumaric acid, ferulic acid, chrysin, pinocembrin, and galangin. Overall, the results indicate that L. albus exhibits moderate antioxidant potential despite its relatively low phenolic content, and its phenolic composition is influenced by geographical origin.

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  İncele
• MakaleAçık Erişim2026Scopus SJRQ1/r/bayburt/12772
  Gastrointestinal stability and bioactivity of propolis from diverse origins

  Can, Zehra; Çelebi, Zeynep Berin; Tunca, Erol; Kolaylı, Sevgi; Sevin, Sedat; Tutun, Hidayet

  Propolis is a chemically complex bee product whose biological properties depend on its botanical and geographical origin. However, little is known about how gastrointestinal digestion affects its phenolic profile and bioactivity. In this study, twelve propolis samples from eight countries were evaluated for phenolic and flavonoid contents, antioxidant capacity (FRAP, ABTS+•), and urease inhibition before and after simulated gastric digestion. RP-HPLC–PDA identified 26 phenolic compounds showing substantial compositional diversity. Turkish Bolu propolis retained the highest post-gastric FRAP value, while several samples (BBP, AFP) maintained or enhanced urease inhibition. PCA and HCA highlighted origin-dependent differentiation, identifying digestive stability as a key variable for functional potential.

  AtıfOpenAlex2

  İncele
• MakaleAçık Erişim2026Scopus SJRQ1/r/bayburt/12675
  Enhanced Absorption-Dominant EMI Shielding Performance of Pyramidal Cementitious Composites Incorporating Recycled Plastics and Magnetite Minerals for 5G Applications

  Cakir, Mehmet; Engin, Mustafa Alptekin; Camuzcuoglu, Murat

  In this study, waste polypropylene (PP) and magnetite (Fe3O4) mineral-reinforced cement-based pyramidal composite structures were designed, manufactured, and experimentally characterized to reduce electromagnetic interference (EMI) problems in the 3.3–4.9 GHz frequency band for 5G communication systems. Unlike traditional planar concrete surfaces, the aim was to minimize surface reflections and obtain an absorption-dominant shielding mechanism by providing gradient impedance matching through the pyramidal geometry. Although the use of carbon-based nanomaterials is common in the current literature, their high cost and corrosion risks limit their large-scale applications. This study involves the evaluation of waste polypropylene disposal and self-enriching magnetite mineral together. Theoretical analyses were supported by the Lichtenecker Logarithmic Mixing Rule and the Maxwell–Garnett model, and seven different mixing scenarios (S1–S7) were measured using the free-space method with a Libre vector network analyzer. Experimental results showed that the pure concrete sample exhibited predominantly reflective behaviour, with shielding performance improving significantly as the filler ratio increased. The S4 sample, containing 15% PP and 10% magnetite, offered broadband and balanced absorption performance, while the S7 sample, containing 25% PP and 25% magnetite, provided the highest shielding effectiveness with reflection below −10 dB across the entire band and transmission loss reaching −65 dB.

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  İncele
• MakaleYalnız künye2026Scopus SJRQ4/r/bayburt/11511
  Microwave assisted green synthesis of nano-sized biogenic silver in extract of Phlomis linearis: potential anticancer and antimicrobial activities

  Orçan Çayır, İlayda; Tahta, Beyhan; Cömertpay, Sabahattin; Uruş, Serhan; Bülbül, Ali Savaş; Aygan, Ashabil; Aksan, Mehmet Emrah

  Silver nanoparticles (AgNPs) are known for their significant anticancer and antimicrobial activities in the field of medicine. In the present study, AgNPs were synthesized using a microwave-assisted green synthesis process, in which Ag(I) ions were reduced by organic compounds extracted from the leaves and stems of Phlomis linearis, an endemic plant which acted as both reducing and stabilizing agents. Although various species of the Phlomis genus have been studied in the literature, the synthesis of the nano-sized biogenic silver with reducing Ag(I) in the extract of the endemic plant P. linearis is reported here for the first study time, along with the evaluations of its bioactive properties. The obtained AgNPs were characterized by optical, structural, morphological, etc. techniques such as Ultraviolet–visible spectroscopy (UV–Vis.), Fourier-Transform Infrared Spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), transmission electron microscopy (TEM), dynamic light scattering (DLS), and photoluminescence (PL). Gas chromatography − mass spectrometry (GC–MS) and FT-IR techniques were used in order to evaluate the biochemical-reduction mechanism. When their antimicrobial activities were determined by the well diffusion method on six bacterial strains, the results showed that P. linearis exhibited antimicrobial activity against all tested bacteria. Additionally, the investigation of the anticancer activity of the particles by using the MTS method on a breast cancer cell line (MCF-7) and a healthy human cell population (human umbilical vein endothelial cells [HUVEC]) revealed that our AgNPs were more cytotoxic toward the cancerous cells compared to the non-cancerous ones (p < 0.001).

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  İncele
• MakaleYalnız künye2026Scopus SJRQ1/r/bayburt/11497
  Structure-guided discovery of submicromolar 1,2,4-triazole–Schiff-base inhibitors of glutathione reductase

  Manap, Sevda; Akar, Hande; Medetalibeyoğlu, Hilal; Atalay, Abdurrahman; Can, Zehra; Kara, Yakup; Alkan, Muzaffer; Beytur, Murat; Yüksek, Haydar; Ortaakarsu, Ahmet Buğra

  Glutathione reductase (GR) plays a crucial role in maintaining cellular redox balance and is a promising target for ferroptosis-based cancer therapies. In this study, we report the design, synthesis, and comprehensive evaluation of a novel series of 1,2,4-triazole–Schiff base succinate derivatives (AUR-514–518) as potent GR inhibitors. In vitro Mannervik assays revealed vigorous submicromolar inhibitory activity, with AUR-517 emerging as the most effective (IC50 = 0.471 ± 0.032 μM), significantly surpassing quercetin (IC50 = 214.5 ± 18.5 μM). Antioxidant profiling revealed negligible radical scavenging activity; however, modest CUPRAC responses suggest a target-specific mechanism. To elucidate the molecular determinants of inhibition, we employed deep-learning–assisted protein–ligand affinity predictions, molecular dynamics simulations, MM/GBSA free-energy calculations, and dimensional reduction analyses. These computational studies revealed dual binding modes at both the catalytic site and dimer interface, with AUR-517 forming stable interactions with key catalytic residues, consistent with experimental potency rankings. The RMSD/RMSF profiles indicated enhanced conformational stability of GR–ligand complexes, while binding energy landscapes underscored the superior stability of AUR-517. Consequently, these findings establish the AUR series as a new class of structurally validated GR inhibitors, with AUR-517 representing a lead scaffold for the rational development of ferroptosis-sensitizing agents with translational potential in oncology.

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  AtıfScopus3·WoS3·OpenAlex5

  İncele
• MakaleYalnız künye2026Scopus SJRQ2/r/bayburt/11367
  Evaluation of post-traumatic stress disorder and food insecurity in earthquake survivors

  Köktürk, Seda Nur; Esgin, Özge; Bulbul, Ali Savas; Sahin, Engin

  Aim: This study aimed to investigate the psychological difficulties and challenges related to food insecurity following the earthquakes in Kahramanmaraş province on February 6, 2023, particularly examining the relationship between Post-Traumatic Stress Disorder (PTSD) and food insecurity among survivors. Subjects and methods: The research included 504 adults (71.4% female). The study assessed the subcomponents of food insecurity and measured PTSD levels among participants. It also evaluated the prevalence of Gastrointestinal System (GIS) issues and appetite loss. Results: Individuals facing food insecurity exhibited higher median PTSD scores compared to those not experiencing food insecurity. A significant majority of individuals with PTSD (90.2%) also encountered GIS issues, with a notable prevalence of appetite loss. GIS problems were common among those experiencing food insecurity. Conclusion: Many disaster victims endure both food insecurity and PTSD, negatively impacting their dietary habits and health. Providing clean, dependable, and nutritious food post-disaster can reduce health risks. Psychological support and therapy for PTSD can aid recovery. More detailed studies on nutritional status are needed for deeper insights.

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  AtıfScopus2·WoS3·OpenAlex4

  İncele
• MakaleYayıncıda açık erişim2026Scopus SJRQ1/r/bayburt/11341
  Turkish validation of the CompACT: assessing psychological flexibility among emergency aid and disaster management students

  Çınar, Öznur; Oral, Vildan; Turan, Melikşah; Cengiz, Ekrem

  Psychological flexibility is a central construct in Acceptance and Commitment Therapy and an important protective factor for mental health, particularly among individuals expected to function effectively under high stress and uncertainty, such as those in emergency aid and disaster management. Despite its relevance for this population, no Turkish version of the Comprehensive Assessment of Acceptance and Commitment Therapy Processes (CompACT) had been available. The present study aimed to perform a cross-cultural adaptation of the English version of CompACT into Turkish and to evaluate its psychometric properties in emergency aid and disaster management students. The study was conducted in two phases: translation and cross-cultural adaptation, followed by psychometric evaluation in a sample of 302 students. Data were analyzed using SPSS v.21 and AMOS v.22 through exploratory and confirmatory factor analyses, reliability analyses, test-retest analysis, and correlational validity testing. The exploratory factor analysis (EFA) showed that the CompACT consisted of three factors (Openness to Experience, Behavioral Awareness, and Valued Action) explaining 75.848% of the total variance, comprising 20 items. Confirmatory factor analysis (CFA) showed that the three-factor model provided the best fit to the data (χ²/df = 2.590, CFI = 0.963, TLI = 0.956, RMSEA = 0.073). The scale demonstrated satisfactory internal consistency (overall alpha = 0.843) and temporal stability (test-retest r > 0.70 across all subscales), and its expected negative associations with the Acceptance and Action Questionnaire-II (r = −0.365) and the Depression Anxiety Stress Scales-21 (r = −0.403) supported its criterion-related validity.

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  AtıfScopus1·WoS1·OpenAlex1

  İncele
• MakaleAçık Erişim2026Scopus SJRQ1/r/bayburt/11256
  When grief persists online: Development of the Digital Prolonged Grief Severity Scale

  Çınar, Öznur; Cengiz, Ekrem

  Bereaved individuals encounter the deceased through social media profiles, message histories, and algorithmic reminders, yet no validated instrument measures prolonged grief expressed through digital interactions. We developed and validated a multidimensional measure of digital-environment prolonged grief severity (DPGSS). Turkish bereaved adults (n = 577) bereaved at least 12 months earlier completed the DPGSS alongside grief, distress, and other less relevant measures, and 125 completed it again about three weeks later. Factor analyses supported a four-factor structure—digital separation distress and preoccupation, digital emotional responses, digital avoidance, and digital functional impairment—in 15 items. The correlated four-factor model fit the data well, outperforming a one-factor alternative. The DPGSS demonstrated strong internal consistency, test-retest reliability, and measurement invariance across nine demographic variables. Convergent associations with grief and distress, and negligible associations with rigidity and AI acceptance, supported its construct specificity. The DPGSS-15 is a reasonable tool for assessing digital prolonged grief.

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  İncele
• MakaleYalnız künye2026Scopus SJRQ2/r/bayburt/11185
  Depth-dependent predictability of soil temperature under Mediterranean climatic conditions: a frequency-based perspective

  Guleryuz, Didem; Yıldırım, Ümit; Güler, Cüneyt

  Soil-temperature predictability is inherently depth-dependent because atmospheric forcing is progressively attenuated and transformed into smoother, lower-frequency thermal dynamics with increasing depth. Under Mediterranean climatic conditions, where pronounced seasonality and strong surface forcing coexist, this depth-dependent transformation provides an informative basis for evaluating model behaviour. This study examines soil-temperature prediction at depths of 5, 10, 20, 50, and 100 cm using a multivariate dataset comprising 5,285 retained daily observations from the Mersin meteorological station on Türkiye’s eastern Mediterranean coast. Precipitation, air temperature, relative humidity, wind speed, and evaporation were used as predictors. Support vector regression, random forest, and LightGBM were evaluated using R², RMSE, and MAE. All three models performed strongly in the near-surface layers, with test R² values ranging from 0.948 to 0.954 at depths of 5–20 cm. Predictive performance declined with increasing depth as short-period variability weakened and the thermal signal became smoother and more seasonally structured. RF and LightGBM showed a greater numerical decline at 50–100 cm, whereas SVR achieved test R² values of 0.923 at 50 cm and 0.847 at 100 cm; however, inter-model differences remained modest and were interpreted descriptively. Lomb–Scargle spectral analysis, applied using the actual observation dates, indicated that short-period variability became relatively less pronounced with depth while seasonal-scale and low-frequency components remained prominent. Overall, the findings suggest that soil-temperature prediction should be interpreted in relation to depth-dependent temporal signal characteristics rather than as a search for a universally superior algorithm.

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  İncele
• MakaleYalnız künye2026Scopus SJRQ4/r/bayburt/10963
  Psychometric Validation of the Turkish Version of the Personalized Psychological Flexibility Index (T-PPFI) in Disaster Search and Rescue Volunteers

  Çınar, Öznur; Cengiz, Ekrem

  This study aimed to perform a cross-cultural adaptation of the English version of the Personalized Psychological Flexibility Index into Turkish (T-PPFI). It was conducted among 604 disaster search and rescue volunteers who participated in the 2023 Kahramanmaraş earthquakes in Türkiye. Exploratory factor analysis supported a three-factor, 15-item structure, and confirmatory factor analysis indicated good fit for the three-factor model. Convergent and divergent validity were supported by a positive correlation with the Comprehensive Assessment of Acceptance and Commitment Therapy Processes (CompACT) and negative correlations with the Acceptance and Action Questionnaire-II (AAQ-II) and the Depression Anxiety and Stress Scales-21 (DASS-21). The T-PPFI showed acceptable internal consistency (total score α= .727; ω= .712) and high test-retest reliability over 14 days (r= .962). Gender measurement invariance analyses supported comparability of T-PPFI scores across men and women. Hierarchical regression analyses provided evidence for the incremental validity of the T-PPFI beyond AAQ-II and CompACT in predicting DASS-21 outcomes, and higher-order EFA supported construct-level discriminant validity. The findings suggest that the 15-item T-PPFI is a reliable and valid measure of psychological flexibility in Turkish disaster search and rescue volunteers. All rights reserved.

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