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• MakaleAçık Erişim2026/r/bayburt/16058
  Comparative evaluation of antioxidant activity and phenolic content of Lupinus albus L. (white bitter lupin, termiye) grown in different regions of Türkiye by RP-HPLC-PDA

  Kara, Yakup; Can, Zehra

  Lupinus albus L. (white bitter lupin) is an important legume species widely cultivated in the Mediterranean region. This study aimed to comparatively evaluate the antioxidant capacity and phenolic composition of L. albus samples collected from different regions of Türkiye. Samples were obtained from Konya (Centre, Akşehir, Doğanhisar), Isparta (Central), and Burdur (Central). Total phenolic content, total flavonoid content and antioxidant activities of samples were determined using FRAP and DPPH assays. Additionally, the qualitative and quantitative profiles of phenolic compounds were analyzed by RP-HPLC-PDA. The total phenolic content was determined to be in the range of 1.96–2.47 mg GAE/g, whereas flavonoids were not detected in any of the samples. The results demonstrated that Lupinus albus L. extracts exhibited notable antioxidant activity, with FRAP values ranging from 1.14 to 1.95 μmol Fe²⁺/g and DPPH (SC₅₀) values ranging from 37.98 to 56.60. The phenolic composition analysis revealed the presence of major compounds including p-hydroxybenzoic acid, p-coumaric acid, ferulic acid, chrysin, pinocembrin, and galangin. Overall, the results indicate that L. albus exhibits moderate antioxidant potential despite its relatively low phenolic content, and its phenolic composition is influenced by geographical origin.

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  İncele
• MakaleAçık Erişim2026Scopus SJRQ1/r/bayburt/12772
  Gastrointestinal stability and bioactivity of propolis from diverse origins

  Can, Zehra; Çelebi, Zeynep Berin; Tunca, Erol; Kolaylı, Sevgi; Sevin, Sedat; Tutun, Hidayet

  Propolis is a chemically complex bee product whose biological properties depend on its botanical and geographical origin. However, little is known about how gastrointestinal digestion affects its phenolic profile and bioactivity. In this study, twelve propolis samples from eight countries were evaluated for phenolic and flavonoid contents, antioxidant capacity (FRAP, ABTS+•), and urease inhibition before and after simulated gastric digestion. RP-HPLC–PDA identified 26 phenolic compounds showing substantial compositional diversity. Turkish Bolu propolis retained the highest post-gastric FRAP value, while several samples (BBP, AFP) maintained or enhanced urease inhibition. PCA and HCA highlighted origin-dependent differentiation, identifying digestive stability as a key variable for functional potential.

  AtıfOpenAlex2

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• MakaleYalnız künye2026Scopus SJRQ1/r/bayburt/11497
  Structure-guided discovery of submicromolar 1,2,4-triazole–Schiff-base inhibitors of glutathione reductase

  Manap, Sevda; Akar, Hande; Medetalibeyoğlu, Hilal; Atalay, Abdurrahman; Can, Zehra; Kara, Yakup; Alkan, Muzaffer; Beytur, Murat; Yüksek, Haydar; Ortaakarsu, Ahmet Buğra

  Glutathione reductase (GR) plays a crucial role in maintaining cellular redox balance and is a promising target for ferroptosis-based cancer therapies. In this study, we report the design, synthesis, and comprehensive evaluation of a novel series of 1,2,4-triazole–Schiff base succinate derivatives (AUR-514–518) as potent GR inhibitors. In vitro Mannervik assays revealed vigorous submicromolar inhibitory activity, with AUR-517 emerging as the most effective (IC50 = 0.471 ± 0.032 μM), significantly surpassing quercetin (IC50 = 214.5 ± 18.5 μM). Antioxidant profiling revealed negligible radical scavenging activity; however, modest CUPRAC responses suggest a target-specific mechanism. To elucidate the molecular determinants of inhibition, we employed deep-learning–assisted protein–ligand affinity predictions, molecular dynamics simulations, MM/GBSA free-energy calculations, and dimensional reduction analyses. These computational studies revealed dual binding modes at both the catalytic site and dimer interface, with AUR-517 forming stable interactions with key catalytic residues, consistent with experimental potency rankings. The RMSD/RMSF profiles indicated enhanced conformational stability of GR–ligand complexes, while binding energy landscapes underscored the superior stability of AUR-517. Consequently, these findings establish the AUR series as a new class of structurally validated GR inhibitors, with AUR-517 representing a lead scaffold for the rational development of ferroptosis-sensitizing agents with translational potential in oncology.

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  AtıfScopus3·WoS3·OpenAlex5

  İncele
• MakaleAçık Erişim2025/r/bayburt/15938
  Comparison of Honey's Physicochemical, Bioactive Components, and Biological Activities from the Eastern Black Sea Region of Türkiye

  Ertürk, Ömer; Çil, Elif; Can, Zehra; Demir, Demet; Bagdatli, Emine

  The aim of this study is to determine and compare the physicochemical and biological characterization of some honey samples in the Eastern Black Sea Region of Türkiye. Physicochemical tests investigated the compliance of honey samples with the Turkish Food Codex. The phenolic components were analyzed by RP- HPLC-PDA. The total phenolic and flavonoid contents (TPC, TFC), antioxidant capacity (FRAP, DPPH), urease, glucose-oxidase, and antimicrobial activity (Disc diffusion, MIC) of the samples were determined, and FTIR and UV-Vis analyses were conducted. The spectra of the honey samples revealed the characteristic bands corresponding to the functional groups of minor components. As a result of the physicochemical analyses, it was determined that some of the samples examined did not comply with the standard values defined in the Turkish Food Codex in terms of the examined parameters. Spectral findings show that honey samples have a rich chemical composition. Anzer honey is preferable to other kinds with its rich phenolic and antioxidant content and relatively high antimicrobial activity.

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  AtıfOpenAlex2·TR Dizin1

  İncele
• MakaleAçık Erişim2025Scopus SJRQ3/r/bayburt/12657
  Chemical and bioactive potential of the nests of Polistes nimpha, Polistes dominula, and Vespa crabro (Hymenoptera: Vespidae)

  Ertürk, Ömer; Can, Zehra; Yaman, Mustafa

  This work was accomplished to establish the chemical components and bioactivity potential of the nest materials of Polistes nimpha (Christ), Polistes dominula (Christ), and Vespa crabro (L.). The biological and chemical compounds of materials and their molecular functionalities were detected using FRAP (ferric reducing antioxidant power) method, DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free radical method, and Energy Dispersive X-Ray Analysis. Finally, the bioactivity potentials of nest extracts were assayed and phenolic components were determined. C, N, O, Na, Ca, K, Mg, Al, Si are the elemental components of the nest materials. All nest extracts of three species had high biological activity against nine bacteria and one fungus causing common infections. The maximum antibacterial and antifungal activity was seen when gram-negative Pseudomonas aeruginosa, gram-positive Bacillus cereus, and gram-positive Candida albicans were exposed to ethanol extracts of nest samples in 25 μL. High antioxidant activity can be found in the nest extracts. These extracts might help researchers find novel antifungal and antibacterial substances.

  İncele
• MakaleAçık Erişim2025Scopus SJRQ2/r/bayburt/11374
  Optimization of Phenolic Compound Extraction from Bee Products via Solvent Systems and PCA Integration

  Birinci, Ceren; Kara, Yakup; Gıdık, Betül; Kolaylı, Sevgi; Can, Zehra

  To achieve a highly selective and sensitive analysis of phenolic compounds in bee products (honey, bee bread, and propolis), a simultaneous quantification of 25 phenolic compounds was performed using high-performance liquid chromatography coupled with a diode array detector. In the study, various solvents were utilized to enhance the phenolic profile of bee products, including pH 2 and 7 ultra-pure water, diethyl ether, and ethyl acetate. These included non-liquid–liquid extraction, pH 2 with 10 mL of pure water and 20 mL of diethyl ether; pH 2 with 10 mL of pure water and 20 mL of ethyl acetate; pH 2 with 10 mL of pure water, 10 mL of diethyl ether, and 10 mL of ethyl acetate; and pH 7 with 10 mL of pure water, 10 mL of diethyl ether, and 10 mL of ethyl acetate. Additionally, the integration of phenolic compounds identified through the enrichment method was pursued using principal component analysis (PCA). The extraction yields and recovery rates of phenolic compounds can be significantly improved by combining and integrating different extraction techniques. Our results demonstrated that using different solvent combinations significantly improved both the yield and diversity of phenolic compounds extracted from the complex matrices of bee products.

  AtıfScopus2·WoS2·OpenAlex1

  İncele
• MakaleYalnız künye2025Scopus SJRQ2/r/bayburt/11001
  Bee bread from Anatolia: its chemical composition, phenolic and aromatic profiles, and antioxidant properties

  Kolayli, Sevgi; Okumus Yukunc, Gulsah; Kara, Yakup; Demir Kanbur, Esra; Can, Zehra; Ozkok, Aslı; Tanugur Samanci, Aslı Elif

  This study investigated the botanical origin, chemical composition, phenolic and volatile aromatic profiles, and antioxidant activities of 11 bee bread samples from different regions of Anatolia, Turkey. The bee bread samples contained high amounts of proteins (19.61 g/100 g) and lipids (6.43 g/100 g). The bee breads were determined to have a rich mineral content. The antioxidant potential of the bee breads was predicted using total phenolic content (TPC), total flavonoid content (TFC), total condensed tannin (TCT) content, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP) assays. The TPC of the bee breads ranged between 2.041 ± 0.170 and 3.224 ± 0.006 mg GAE/g, while the TFC ranged from 0.323 ± 0.004 to 1.903 ± 0.017 mg QE/g. The FRAP assay showed antioxidant activity ranging from 17.778 ± 0.207 to 49.752 ± 0.856 µmol FeSO4.7H2O/g, and the DPPH values were between 1.054 ± 0.009 and 4.366 ± 0.014 SC50 mg/mL. Using 25 standards, RP-HPLC-PDA quantified the composition of the phenolic compounds, attributed to their antioxidant activity. The highest concentrations were detected for t-cinnamic acid, rutin, and p-coumaric acid. One hundred nineteen volatile aromatic compounds were determined in the bee breads by solid-phase microextraction coupled with gas chromatography and mass spectrometry (SPME-GC-MS). The obtained values suggest that bee breads could serve as a potential source of nutrients and bioactive compounds for value-added food supplements and functional foods.

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  AtıfScopus12·WoS13·OpenAlex15

  İncele
• MakaleAçık Erişim2025Scopus SJRQ2/r/bayburt/10986
  A Promising Antibacterial Inhibition of Propolis Extracts Against Carbapenem-Resistant Bacteria Isolated From Clinical Samples

  Esertaş, Ülkü Zeynep; Inal, Neşe; Can, Zehra; Kolaylı, Sevgi

  The increasing inadequacy of antibiotics against multidrug-resistant pathogens is a growing concern. In this study, the antibacterial activity of propolis extracts with different phenolic profiles against carbapenem-resistant clinical isolates was investigated. The antimicrobial activity of propolis extract was tested against Acinetobacter baumannii (K17, K16, and K21), Klebsiella pneumoniae (K22, and K19), and Stenotrophomonas maltophilia (E5, E7, and E4) bacterial strains isolated from tracheal aspirate and blood cultures. The total phenolic content and phenolic composition of the extracts were analyzed. Antimicrobial activity values examined according to the disk diffusion method were measured as minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The results showed that all propolis extracts showed different inhibition values against bacterial strains. As a result, the high inhibitory potential of the propolis extracts against resistant bacteria such as A. baumannii, K. pneumoniae, and S. maltophilia is promising for combating infections. However, the study needs to be supported by further randomized clinical studies.

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  AtıfScopus2·WoS2·OpenAlex4

  İncele
• MakaleAçık Erişim2024/r/bayburt/14177
  Investigation of Some Tree Bark Extracts and Essential Oils for Antioxidant, Antimicrobial and Anti-Quorum Sensing Activities

  Yilmaz, Bilge; Tabbouche, Sana; Deniz, Ilhan; Kiliç, Ali Osman; Can, Zehra

  Aim of study: The objective of this research is to uncover the bioactive characteristics of ethanol extracts and essential oils from 15 different tree barks (Thuja plicata, Sequoia sempervirens, Eucalyptus globulus, Pinus nigra, Platanus orientalis, Fagus orientalis, Populus tremula, Castanea sativa, Pinus sylvestris, Pinus pinaster, Picea orientalis, Populus nigra, Cryptomeria japonica, Abies nordmanniana, Quercus robur). Material and method: In this study, the bioactive properties of 15 different tree barks were investigated. Ethanol extracts were analyzed for their polyphenolic content, antioxidant activity, and antimicrobial properties. Additionally, the essential oils were evaluated for their anti-quorum sensing capabilities. Main results: Several barks demonstrated high potential as sources of polyphenolic compounds, tannins, and antioxidant activity, indicating their potential as bioactive resources for the forestry and pharmaceutical industries. Research highlights: The ethanol extracts of Eucalyptus globulus, Castanea sativa, and Quercus robur barks showed remarkable results regarding total polyphenolic content, antioxidant activity, and antimicrobial properties. Essential oils from the barks of Populus nigra, Populus tremula, and Platanus orientalis exhibited positive anti-quorum sensing activity. Moreover, both Quercus robur and Eucalyptus globulus displayed high bioactive potential.

  AtıfWoS1·OpenAlex1

  İncele
• MakaleAçık Erişim2024Scopus SJRQ3/r/bayburt/13148
  Antioxidant Activities of Different Peanut (Arachis hypogaea L.) Market Types by Spectrophotometric Techniques Combined with Chemometrics

  Gıdık, Betül; Can, Zehra; Önemli, Fadul

  Peanut is rich in oil and protein and has a large content of bioactive constituents consisting of tocopherols, phytosterols, and so on. Generally, Virginia, Spanish, Valencia and Runner market types are grown of peanut. In this study, it is aimed to determine the antioxidant activity, total phenolic content and total flavonoid content of peanuts from four different market types, for the first time, and group them with principal component analysis (PCA) and hierarchical cluster analysis (HCA). For PCA, PC1 and PC2 explained 87.655 % of the total variation and, according to the HCA of peanut samples, two main groups were determined. The total phenolic content changed 1.556 to 2.899 mg GAE/g. The lowest value have seen at Spanish merket type to determine the antioxidant activities of peanut samples were maked FRAP and DPPH assay, the lowest FRAP value (8.136 μmol FeSO47H2O/g sample) was seen at Valencia market type, the highest (14.004 μmol FeSO47H2O/g sample) was seen at Virginia market type. It was determined that the total flavonoid, total phenolic content, and antioxidant activities of the Virginia, Valencia, Spanish, and Runner market types included in the study were different from each other, and the Virginia market type showed superior characteristics compared to the others. The results obtained suggest that Virginia market type may be preferred more especially in peanut cultivation for food uses. It is thought that this study can be a source for future studies by eliminating a deficiency in the literature.

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  AtıfScopus2·WoS2·OpenAlex2

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