Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Kutlu, Naciye(11)
- Şahin, Engin(6)
- Ecem Bayram, Nesrin(5)
- Sönmez Sari, Ebru(5)
- Can, Zehra(4)
- Gerçek, Yusuf Can(3)
- Gıdık, Betül(3)
- Kalay, Erbay(3)
- Kamiloğlu, Aybike(3)
- Kızıl, Hamit Emre(3)
- Saritas, Serdar(3)
- Semerci Çakmak, Vahide(3)
- Teber, Ahmet(3)
- Abca, Tuğba Elbir(2)
- Abdioglu, Murat(2)
- Aksoy, Dilara Arzugül(2)
- Apaydin, Emine(2)
- Arslaner, Ayla(2)
- Bayram, Nesrin Ecem(2)
- Bayram, Sinan(2)
- Baştürk, Fatma Nur(2)
- Birinci, Ahmet(2)
- Dertli, Enes(2)
- Gercek, Yusuf Can(2)
- Guner, Sait Baris(2)
- Gunes, Huseyin(2)
- Isci, Asli(2)
- Kahveci, Hakan(2)
- Kamiloglu, Aybike(2)
- Kara, Yakup(2)
- Koroglu Kaba, Nagihan(2)
- Ozdemir, Ahmet(2)
- Sakiyan, Ozge(2)
- Terzi, Handan(2)
- Tozlu, Alperen(2)
- Çelik, Saffet(2)
- Öztekin, Sebahat(2)
- Acar, Emre Ali(1)
- Adal, Samiye(1)
- Adiyaman, Gokhan(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ1Cross-Cultural Patterns in Artificial Intelligence Literacy Development: Investigating Country and Gender Differences Among Pre-Service Teachers in Germany and Türkiye
Aksoy, Meltem; Aksoy, Dilara Arzugül; Polat, Elif; Hopcan, Sinan; Bush, Annika
As artificial intelligence (AI) rapidly transforms educational landscapes worldwide, developing AI literacy among pre-service teachers has become increasingly crucial for effective classroom integration and responsible implementation. This comparative study examines AI literacy levels among pre-service teachers in Türkiye (Turkey officially changed its name to Türkiye in a 2022 letter to the UN, with the change taking immediate effect. See here) and Germany, addressing a critical gap in cross-cultural educational research. Using the Scale for the Assessment of Non-Experts' AI Literacy (SNAIL), we analysed data from 605 participants through correlation, ANOVA and MANOVA methods. Our findings reveal significant effects of both country and gender on AI literacy development, with German participants demonstrating higher overall literacy scores than their Turkish counterparts, particularly in critical appraisal and practical application dimensions. Conversely, Turkish participants exhibited stronger technical understanding. Across both countries, male participants consistently achieved higher AI literacy scores than females, though this gender gap was most pronounced in technical understanding. The country variable emerged as the more influential factor across all subdimensions. These results highlight the interplay between educational systems, cultural contexts and gender on AI literacy acquisition, offering valuable insights for teacher education programs seeking to prepare educators for increasingly AI-integrated learning environments.
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İncele - MakaleAçık Erişim2026Scopus SJRQ1Nurses’ Workplace Discrimination Experiences and Their Reflections on Career Development: A Qualitative Study
Koroglu Kaba, Nagihan; Apaydin, Emine; Kulakaç, Nurşen
Aim: This study was conducted to examine how nurses experience discriminatory behaviors in the workplace and how these experiences are reflected in their career development. Background: Although discrimination constitutes a significant challenge in nurses’ professional lives, qualitative research examining how these experiences influence their career development processes remains limited. Methods: This phenomenological study was conducted with nurses working in a public hospital in Turkey. Semi-structured individual interviews were conducted with 21 nurses during the study. Participants were selected from various clinical settings through purposive sampling. Data were analyzed using Colaizzi's seven-step content analysis method. Ethics committee approval was obtained for this study. The Consolidated Criteria for Reporting Qualitative Research checklist guided the study reporting. Results: Five main themes with seven subthemes emerged: (1) Discrimination Experiences (types of discrimination, sources of discrimination, emotions/feelings), (2) Reporting Behavior (decision and consequences of reporting, reasons for not reporting), (3) Impact of Discrimination on Career Development (supportive effect, hindering effect), (4) Coping Strategies, and (5) Suggestions for Preventing Discrimination. Discussion: These themes highlight that discrimination is a multidimensional phenomenon and that holistic approaches must be developed at emotional, structural, professional, and institutional levels to cope with it. Conclusion: For some nurses, discrimination acts as a transformative process that supports career development, while for others, it represents a significant barrier to professional advancement. Implications for Nursing/Nursing Policy: The findings highlight the need to strengthen reporting mechanisms, establish a supportive work culture, and implement inclusive institutional policies that promote career development.
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İncele - MakaleAçık Erişim2026Scopus SJRQ3Association of Plasma miRNA-7-5p and miRNA-214-5p With Rheumatoid Arthritis Associated Interstitial Lung Disease
Sahinoğlu, Irem; Karakas, Umit; Uslu, Sadettin; Kizilirmak, Deniz; Acar, Emre Ali; Tasgöz, Filiz Cemre; Kacar, Mevlüt; Sülükcü, Seref; Sengül, Merve Türkegün; Erdal, Mehmet Emin
Objective: Rheumatoid arthritis–associated interstitial lung disease (RA-ILD) is a major extra-articular complication contributing to increased morbidity and mortality. Circulating microRNAs (miRNAs) have emerged as potential non-invasive biomarkers in autoimmune diseases. This study aimed to evaluate whether plasma miRNA-7-5p and miRNA-214-5p are associated with the presence of RA-ILD and with radiological and functional indicators of pulmonary involvement. Methods: In this cross-sectional study, 58 RA patients (29 RA-ILD, 29 without ILD) and 30 matched healthy controls were included. RA-ILD was diagnosed by multidisciplinary assessment (HRCT and pulmonary function tests). Plasma miRNA levels were measured by qRT-PCR and analyzed using the 2^−ΔΔCT method. Diagnostic performance was evaluated by ROC analysis. Results: Plasma miRNA-7-5p and miRNA-214-5p levels were significantly higher in RA patients compared with healthy controls (p < 0.05 for both). Among RA patients, both miRNAs were significantly lower in those with ILD (p < 0.05). miRNA-7-5p demonstrated promising discriminatory performance for identifying RA-ILD (AUC = 0.87, 95% CI: 0.760–0.947; p < 0.001), whereas miRNA-214-5p showed modest accuracy (AUC = 0.676, 95% CI: 0.539–0.794; p = 0.01). In multivariable analysis, ILD presence was independently associated with decreased levels of both miRNAs. Neither miRNA correlated significantly with DAS28-CRP, disease duration, nor with radiological or functional severity parameters. Conclusion: Circulating miRNA-7-5p and miRNA-214-5p are associated with the presence of RA-ILD but do not reflect disease severity in this cohort. Larger prospective studies are required to validate their potential role as adjunctive biomarkers for RA-ILD detection and risk stratification.
- MakaleAçık Erişim2026Scopus SJRQ3Anatomical and Phytochemical Characterization of Ranunculus pinardii and Ranunculus constantinopolitanus: LC-MS/MS-Based Bioactive Compound Profiling
Feizollahi, Sepideh; Gercek, Yusuf Can; Canlı, Deniz; Basturk, Fatma Nur; Yesil, Yeter; Kösesakal, Taylan; Ecem Bayram, Nesrin
The aim of this study was to characterize Ranunculus pinardii and Ranunculus constantinopolitanus species anatomically and phytochemically. In order to contribute to the taxonomic characterization of R. pinardii and R. constantinopolitanus, anatomical structures of the stem, leaf, and petiole of species were examined with light microscopy. Total phenolic-flavonoid content, antioxidant activity, total anthocyanin, total proanthocyanidin, and individual phenolic compounds of extracts prepared with different solvents were determined. The results showed that the total phenolic contents of the species had a similar range (0.09-0.45 mg GAE/g for R. pinardii and 0.01-0.44 mg GAE/g for R. constantinopolitanus), but R. constantinopolitanus exhibited higher antioxidant activity (29.28 mg TE/g). Higher individual phenolic compound recovery was achieved from R. pinardii compared to R. constantinopolitanus with all solvents, except methanol. Both species were rich in luteolin, a natural flavonoid (163.98-34417.11 µg/kg for R. pinardii and 44.93-129009.44 µg/kg for R. constantinopolitanus). These results indicate that these plants contain bioactive ingredients that may have applications in different fields, such as medicine, cosmetics, and food. In particular, the detection of luteolin compound at high levels in these species compared to other components indicates that optimization studies aimed at the recovery of luteolin are important for future research.
- MakaleAçık Erişim2026Scopus SJRQ1Ultrasonic-Assisted Deep Eutectic Solvent Extraction of Polyphenols From Tea Parts: A Green Assessment
Gerçek, Yusuf Can; Baştürk, Fatma Nur; Gıdık, Betül; Abca, Tuğba Elbir; Yurtvermez, Bayram; Fuente-Ballesteros, Adrián; Kutlu, Naciye; Ecem Bayram, Nesrin
Deep eutectic solvents (DESs) have emerged as green alternatives to conventional solvents for extracting bioactive compounds from plants. This study evaluated nine choline chloride–based DESs for recovering antioxidant polyphenols from four parts of the tea plant (Camellia sinensis): seed, bud, leaf, and flower. Total phenolic content, antioxidant activity, and individual polyphenolic profiles were determined, and the greenness of the sample preparation was assessed using AGREEprep. The highest total phenolic content (53.28 mg GAE/g) and antioxidant activity (141.17 mg TE/g) were obtained from leaves using ChCl:formic acid, outperforming ethanol and methanol. Leaves also exhibited the highest total quantified polyphenolic content (up to 95,813 mg/kg DW, corresponding to the sum of the quantified polyphenols), with epicatechin gallate and gallocatechin + epigallocatechin being the major contributors. Flowers and buds showed notable polyphenolic diversity, while seeds contained the lowest levels. Statistical analysis confirmed clear clustering patterns according to plant part and solvent type. AGREEprep evaluation yielded scores up to 0.54, highlighting the environmental benefits of DES-based extraction. We demonstrated that tea leaves were the richest source of bioactive polyphenols, and selected DESs, particularly formic acid–based and ethylene glycol–based, exhibited superior efficiency and sustainability compared to conventional solvents. These findings support the wider adoption of DESs for green, high-yield extraction of pharmacologically important compounds from tea and other medicinal plants.
- MakaleAçık Erişim2026Scopus SJRQ3Financial Management of Traditional and Complementary Medicine in Türkiye Public Hospitals: A Policy Analysis of Pricing, Accounting, and Performance Incentives
Kılınç, Mehmet
This article presents a policy analysis of the financial management of Traditional and Complementary Medicine (T&CM) practices in public hospitals in Türkiye, with a focus on the intersection of pricing, accounting, and performance-based supplementary payment systems. While integrating T&CM into the modern healthcare system expands treatment options, it introduces significant administrative challenges. In recent years, the presentation of T&CM applications in public hospitals in Türkiye has become widespread. However, this expansion has raised critical questions, such as how these services will be charged and how the revenue generated will be accounted for. In this context, the extent to which current pricing policies support the sustainability of T&CM services is discussed. Adopting a descriptive policy analysis approach supported by analytical simulations, this study assesses the adequacy of current pricing policies. The findings reveal a systemic “performance paradox”: although time-intensive, T&CM procedures yield significantly lower performance scores per hour than standard outpatient services, creating a structural disincentive for physicians. Furthermore, the lack of transparency in cost-center accounting complicates the financial sustainability of these units. The study concludes by offering tiered policy recommendations—ranging from low-effort coefficient adjustments to high-effort payment model reforms—to align financial incentives with the strategic goal of integrating T&CM into the public health system.
- MakaleAçık Erişim2026Scopus SJRQ2Probiotic Yogurt With Chokeberry (Aronia melanocarpa (Michx.) Elliot) Sauce Flavored With Date (Phoenix dactylifera L.) Fruit: Comparison of Nero and Viking Cultivars
Arslaner, Ayla; Yücetepe, Aysun; Akköse, Ahmet
The present study investigated the effect of adding chokeberry sauce (CS) from different cultivars (Nero and Viking) on specific quality attributes, total phenolic contents, antioxidant activity, textural qualities, sugar profile, probiotic shelf life, and sensory properties of probiotic yogurts, which were assessed throughout 21 days of cold storage. The results revealed that CS decreased fat, hardness, adhesiveness, and gumminess while increasing ash, total sugar, dry matter, and total calories. From Day 1 to Day 14 of storage, the pH values of CS-added samples significantly decreased (p < 0.01), whereas those in the control remained unchanged (Ky: 0% CS). The springiness and cohesiveness values of the Ky and Vy (20% Viking-CS) samples were comparable. During storage, CS-added yogurt samples’ water-holding capacity (WHC) was significantly higher than that of the control (p < 0.01). Interestingly, yogurt samples showed a notable rise in viscosity up to 14 days of storage, after which they slightly reduced. Ny (20% Nero-CS) and Vy samples exhibited higher red-blue hues than Ky. Vy had greater Lactobacillus acidophilus La-5 survival rates (99.28%) than Ny (99.04%). CS-added samples exhibited significantly higher antioxidant activity, total phenolic content, and total monomeric anthocyanin content compared to Ky; Vy also had the highest values (p < 0.05). Vy showed relatively high scores regarding organoleptic properties, including appearance, taste, texture and consistency, fruit ratio, overall acceptability, and average score. These indicators could help develop a healthier, low-calorie probiotic CS-added yogurt that competes with natural fruit-added yogurt.
- MakaleYalnız künye2026Scopus SJRQ2Multi-Pathway Renoprotection by Betanin Against Docetaxel Nephrotoxicity: Modulation of Inflammation, ER Stress, Apoptosis, and Ferroptosis
Süzen Celbek, Büşra; Akaras, Nurhan; Şimşek, Hasan; Mutlu, Hüseyin; Kızıl, Hamit Emre; Kandemir, Özge; Aygörmez, Serpil; Kandemir, Fatih Mehmet
Docetaxel (DTX), a cornerstone chemotherapeutic agent, has its clinical utility significantly limited by dose-dependent nephrotoxicity. This study investigated the multi-pathway renoprotective mechanisms of betanin (BTN), a natural antioxidant derived from beetroot, against DTX-induced kidney injury. Male Wistar rats received DTX (30 mg/kg, i.p., single dose) with or without BTN (100 mg/kg/day, p.o.) for 7 days. DTX induced severe renal dysfunction with elevated serum urea and creatinine, and significant oxidative stress characterized by increased MDA and decreased GSH, GPx, SOD, and CAT. Molecular analysis demonstrated widespread upregulation of pro-inflammatory (NF-κB, TNF-α, IL-1β), endoplasmic reticulum stress (PERK, ATF6), pro-apoptotic (Caspase-3, Bax, Apaf-1), and pro-ferroptotic (PTGS2, TfR1) mediators, with concurrent downregulation of protective Bcl-2 and GPx4. Histopathological examination revealed extensive tubular injury, while immunohistochemical analysis showed markedly increased kidney injury marker KIM-1 and decreased aquaporin-1 expression. Remarkably, BTN co-administration significantly attenuated all biochemical, molecular, and structural derangements, restored tissue architecture, and normalized KIM-1 and AQP-1 expression. In conclusion, betanin provides robust, multi-pathway renoprotection against docetaxel-induced nephrotoxicity by concurrently targeting oxidative stress, inflammation, ER stress, apoptosis, and ferroptosis.
- MakaleAçık Erişim2026Scopus SJRQ1Deep Eutectic Solvents as Sustainable Media for Efficient Recovery of Phenolics From Black (Lycium ruthenicum Murr.) and Red (Lycium barbarum Lam.) Goji Berries: Optimization and Functional Evaluation
Gerçek, Yusuf Can; Kutlu, Naciye; Çelik, Saffet; Bayram, Sinan; Çevik, Berke; Baştürk, Fatma Nur; Özmener, Bahar; Ecem Bayram, Nesrin
Deep eutectic solvents (DESs) have been frequently preferred over the past decade as alternatives to conventional solvents for the extraction of bioactive compounds from natural products. Meanwhile, black and red goji berries are widely consumed as functional foods due to their many functional properties reported in the literature. The aim of this study is to evaluate the effectiveness of different DESs in the extraction of individual phenolic compounds from goji berry (Lycium barbarum and L. ruthenicum) fruits, to determine the most suitable DES, and to optimize the extraction conditions. The DES that provided the highest yield in the extraction of individual phenolic compounds from L. barbarum was determined to be proline:citric acid (DES6 – a total of approximately 33,545 µg/kg), while for L. ruthenicum it was choline chloride:acetic acid (DES3 – a total of approximately 37,496 µg/kg). Rutin was the predominant phenolic compound in both species. DESs provided a higher phenolic yield compared to ethanol and water. In addition, L. ruthenicum exhibited higher total phenolics, flavonoids, proanthocyanidins, and antioxidant activity compared to L. barbarum. These findings reveal that DESs are a green, efficient, and sustainable alternative for the extraction of phenolic compounds from goji berries.
AtıfScopus1WoS1İncele - MakaleAçık Erişim2026Scopus SJRQ1Nurses’ Ethical Reasoning About Digital Ethical Risks: A Vignette-Elicited Qualitative Study
Bal, Betül; Köroğlu Kaba, Nagihan; Apaydin, Emine
Aim: This qualitative study aimed to explore how nurses reason ethically about potential digital ethical risks arising from the routine use of digital systems in clinical practice and the strategies they propose to address these risks in response to vignette-based scenarios. Background: Digital systems shape nursing documentation, monitoring, communication, education, and decision-making. Although they support care, digital ethical risks may arise when digital outputs are accepted without clinical verification, patients are not adequately informed, or data protection is weak. Design: A vignette-elicited qualitative design was used. Methods: The study was conducted in September 2025 with 16 nurses working in three public hospitals in Central Anatolia, Türkiye. Data were generated through face-to-face interviews using seven vignette-based scenarios and analyzed using Braun and Clarke's reflexive thematic analysis. Results: Three main themes were generated through the analysis of nurses’ ethical reasoning in response to the vignette-based scenarios: (i) nurses’ purposes for using digital systems, (ii) digital ethical risks in nursing, and (iii) strategies to prevent digital ethical risks. The findings within Themes 2 and 3 were organized into four subthemes—nonmaleficence and beneficence, autonomy and respect for persons, justice and equity, privacy and confidentiality—and further structured across three researcher-developed categories: nurse, digital system, and organization. Conclusions: Participants’ interpretations of the vignette-based scenarios highlighted potential digital ethical risks that may require nurses to combine clinical judgment with ethical reasoning when using digital systems. Implications for Nursing: Participants’ responses may inform digital ethics education by highlighting the importance of verifying digital data through bedside assessment, questioning potentially unsafe digital outputs, protecting confidentiality, obtaining meaningful consent, and recognizing potential risks in documentation, alarms, communication, and data sharing. Implications for Health Policy: Participant-identified priorities may inform institutional consideration of protocols for documentation, alarm management, mobile communication, image sharing, access control, patient information, accessibility, and accountability in digital nursing care.
- MakaleYalnız künye2026Scopus SJRQ1Perceived Organizational Support and Nurses' Job Performance: The Indirect Roles of Burnout and Quiet Quitting
Koroglu Kaba, Nagihan; Taskiran Eskici, Gülcan; Tiryaki Sen, Hanife
Perceived organizational support is an important organizational resource that may shape nurses' psychological well-being, workplace engagement, and performance-related outcomes. This study examined the relationship between perceived organizational support and nurses' job performance and explored whether burnout and quiet quitting showed indirect associations consistent with mediation. A cross-sectional correlational study was conducted in a tertiary university hospital in the Black Sea Region of Türkiye. Of 980 eligible nurses, 439 responded (response rate: 44.8%); after excluding 14 questionnaires, 425 nurses were included in the final analysis, representing 43.4% of the eligible population. Data were collected using standardized instruments measuring perceived organizational support, burnout, quiet quitting, and individual work performance. Descriptive statistics, Pearson correlation analysis, and multiple mediation analysis using Hayes' PROCESS macro were performed. Perceived organizational support was positively correlated with job performance (r = 0.27, p < 0.001) and negatively correlated with burnout (r = −0.47, p < 0.001) and quiet quitting (r = −0.37, p < 0.001). Burnout (r = −0.31, p < 0.001) and quiet quitting (r = −0.31, p < 0.001) were negatively correlated with job performance. The total effect of perceived organizational support on job performance was significant (b = 0.23, β = 0.27, p < 0.001). The direct association between perceived organizational support and job performance remained significant even after accounting for burnout and quiet quitting (b = 0.10, β = 0.12, p = 0.025). Significant indirect associations were observed through burnout (b = 0.07, β = 0.08, 95% CI = 0.03–0.12) and quiet quitting (b = 0.06, β = 0.07, 95% CI = 0.03–0.09). These findings suggest that supportive organizational environments may be associated with higher job performance among nurses by reducing burnout and quiet quitting. Given the cross-sectional design, these findings should be interpreted as associations consistent with mediation rather than causal evidence. The study was conducted in a single tertiary university hospital in the Black Sea Region of Türkiye, which may limit generalizability to other settings.
- MakaleAçık Erişim2026Scopus SJRQ1Corn Oil Oleogel With γ-Oryzanol/β-Sitosterol: Structural, Thermal, Textural, and Oxidative Characterization
Elbir Abca, Tuğba; Gençcelep, Hüseyin
In this study, a corn oil oleogel was prepared using γ-oryzanol and β-sitosterol to create a “healthier solid fat-like” structure aimed at reducing saturated and trans fat consumption. To prepare six different oleogels, a γ-oryzanol:β-sitosterol mixture (60:40) was added to corn oil at concentrations ranging from 6% to 15%. The samples were comprehensively evaluated in terms of oil-binding capacity and color; thermal behavior (including melting/crystallization properties); crystal structure; texture properties (hardness, stickiness, cohesion, and spreadability); molecular interactions and oxidative stability. The findings showed that all formulations had high oil binding capacity and that increasing the oleogelator concentration had a limited effect on oil binding. It has been determined that concentration plays an important role in the product's thermal resistance. Results show that as the oleogelator ratio increases, the structure becomes stronger and more durable; the melting behavior in thermal measurements shifts to higher temperatures. Crystal structure analyses support the formation of an oleogel network, while FTIR results indicate that the structure is formed predominantly through physical interactions. Consequently, it has been demonstrated that corn oil can acquire solid fat-like functional properties through this approach and offers a viable option for developing healthier fat formulations, particularly in spreadable products, margarine, and bakery fats.
- MakaleAçık Erişim2025Scopus SJRQ2Social Media Addiction and Cognitive Behavioral Physical Activity Among Adolescent Girls: A Cross-Sectional Study
Sönmez Sari, Ebru; Terzi, Handan; Şahin, Didem
Objective: To measure a multivariate analysis of social media addiction and cognitive-behavioral physical activity associated with several sociodemographic characteristics in adolescent girls. Design and Methods: A cross-sectional study. The sample consisted of adolescent girls studying in a vocational high-school in the Middle-Black-Sea region in Türkiye (n = 333). A questionnaire, Social Media Addiction Scale-for-Adolescents (SMAS-A), and Cognitive-Behavioral Physical Activity Questionnaire (CBPAQ) were used to collect the data. Results: The mean age was 15.35 (SD = 1.15), and 29.4% were the ninth-class students. Of the adolescent girls, 85.9% were social-media users, 59.8% used the internet 2-hours-or-more/daily, 67.9% declared themselves as moderately-active. The mean scores of the SMAS-A and the CBPAQ were 3.40 (SD = 1.61) and 21.03 (SD = 7.64), respectively. There was a significantly-negative correlation between cognitive-behavioral physical activity and social-media addiction levels. The One-Way MANOVA results showed significant differences in the academic level, family income, mother education, and physical activity measurement application usage affected to cognitive-behavioral physical activity. Social media usage habit affected to the social media addiction level. Conclusions: Daily internet usage time and self-declared physical activity level were the mutually affected factors. School nurses should act to improve healthy social media usage habits to promote well-being and encourage the positive attitudes towards regular physical activity in this population.
AtıfScopus13WoS14İncele - MakaleAçık Erişim2025Scopus SJRQ2Fear of Falling Avoidance Behavior on Daily Living Activities and Physical Activity in Older Adults: A Cross-Sectional Study
Türkmen Keskin, Sultan; Sönmez Sari, Ebru; Canbulat, Şahinde; Öztürk, Fatma Özlem
The aim of this study was to investigate the effect of avoidance behavior due to fear of falling on dependency levels in activities of daily living and physical activity levels in older adults. This study is a cross-sectional research design. Data were collected between November 2023 and March 2024. A total of 506 individuals aged 65 years and over participated in the study (mean age 71.26). It was determined that the older adults had low level of fear of falling avoidance behaviors were fully independent in activities of daily living and had low level of physical activity. The multiple linear regression analysis showed that age, marital status, education, living with and fear of falling avoidance behavior affected daily living activities; age, place of residence, gender, income status, chronic disease status, and fear of falling avoidance behavior affected physical activity level (R2 = 0.183; R2 = 0.197, respectively). This study revealed the necessity of interventions to prevent fear of falling avoidance behaviors in order to increase the activities of daily living and physical activity levels among older adults.
AtıfScopus14WoS12OpenAlex15İncele - MakaleAçık Erişim2025Scopus SJRQ1Pharmacological Potential and Bioactive Components of Wild Anatolian Sage (Salvia aethiopis L.)
Bilginoğlu, Emine; Kızıl, Hamit Emre; Öğütcü, Hatice; Ağar, Güleray; Bağcı, Yavuz
Salvia aethiopis L., a member of the Lamiaceae family, has gained attention due to its bioactive compounds with potential therapeutic applications. This study investigated the chemical composition and biological activities of S. aethiopis ethanol extract collected from Karaman province, Türkiye. The phenolic profile of the plant was characterized using LC–MS/MS analysis, which revealed substantial amounts of rosmarinic acid, ferulic acid, caffeic acid, and p-coumaric acid. The antimicrobial activity of the extracts was evaluated against various Gram-positive and Gram-negative bacteria, as well as fungal strains, using the agar well diffusion method. The results demonstrated potent antibacterial effects, particularly against Staphylococcus aureus, Micrococcus luteus, and Klebsiella pneumoniae. Furthermore, the cytotoxic potential of S. aethiopis was assessed on H-460 non-small cell lung cancer cells. The extract exhibited a dose-dependent cytotoxic effect, with a significant reduction in cell viability after 24 and 48 h of treatment, yielding IC50 values of 80.08 and 56.19 μg/mL, respectively. These findings suggest that S. aethiopis possesses promising antimicrobial and anticancer properties, which could contribute to the development of novel therapeutic agents.
AtıfScopus8WoS7OpenAlex7İncele - MakaleAçık Erişim2025Scopus SJRQ1Perceptions of Good Death and Death Literacy Levels of Nurses Working in Palliative Care: A Cross-Sectional Study
Seven, Ahmet; Sari, Ebru Sönmez; Semerci, Vahide
Aim: To determine the perceptions of good death and death literacy levels of Turkish nurses working in palliative care services and the factors affecting their perceptions of good death. Background: Death literacy is defined as the acquisition of the knowledge and skills necessary to understand end-of-life care and contribute to a good death. Methods: For this cross-sectional study, sample consisted of 162 Turkish nurses working in palliative care services. The data were collected using the Socio-demographic Information Form, Good Death Scale (GDS), and Death Literacy Index (DLI). The data were analyzed by Pearson correlation, independent sample t test, and one-way ANOVA. Hierarchical regression analysis was performed to determine the predictors of good death perception. The STROBE checklist was used in the study. Findings: The mean GDS score was 59.53 ± 4.49, and the mean DLI score was 100.70 ± 12.11. It was determined that those who are older, male, married, have worked longer in the clinic, and have knowledge about a good death have higher average scores on the GDS. The models explain 91.8% of the variance in the perception of good death. Discussion: Our study shows that as death literacy increases, nurses’ perceptions of a good death tend to decrease. This situation suggests that as nurses’ knowledge and awareness of death increase, the inadequacies of the healthcare system and the impact of limited resources may cause them to develop a more negative perception. Death literacy in nurses is a new concept, and further studies are needed in different cultures. Conclusions: In the study, it was observed that death literacy levels and good death perceptions of nurses were above average, and as the death literacy level of nurses increased, their good death perceptions decreased. Age, gender, marital status, working time in the clinic and knowledge about good death affect the perception of good death of nurses working in palliative care. Implications for nursing: By improving their understanding of death literacy and the principles of a good death, palliative care nurses can achieve greater job satisfaction and develop a more positive attitude toward end-of-life care. In addition, systematically incorporating death literacy into nursing education curricula and continuing professional development programs, and the establishment of evidence-based clinical guidelines and standard care protocols will improve the quality of palliative care services.
AtıfScopus5WoS5OpenAlex6İncele - MakaleAçık Erişim2025Scopus SJRQ2Lyapunov-based adaptive state-space controller for liquid level control of a coupled tank system with unknown model
Lotfieghlim, Armin; Sekban, Hayriye Tuğba; Başçi, Abdullah
In this paper, a Lyapunov-based adaptive state space controller is designed to realize liquid level control in a coupled tank system. The proposed controller is a kind of adaptive control system that combines the principles of state space representation with Lyapunov stability theory to estimate unknown parameters and control a dynamic system. This approach ensures that the system remains stable even when the exact model parameters are unknown or change over time. Moreover, in order to test the performance of the proposed controller, proportional integral (PI) + feedforward (FF) controller is also applied to the same system under the same conditions and the results are compared. The results show that the proposed controller outperforms the PI + FF controller in terms of system response parameters such as rise time, percent overshoot, and settling time. On the other hand, when the error performance metrics integral squared error (ISE), integral time-weighted squared error (ITSE), integral time-weighted absolute error (ITAE), and integral absolute error (IAE) are evaluated, it is seen that the same situation is also realized here, and the proposed controller follows the reference signals with lower error values in real-time studies for different reference signals.
- MakaleAçık Erişim2025Scopus SJRQ1Optimization of Hemp Seed (Cannabis sativa L.) Protein Extraction and Glycation Conditions by Response Surface Methodology: Physicochemical, Functional, and Thermal Characteristics
Yüzer, Elvan; Kutlu, Naciye; Yüzer, Mustafa Onur
In this study, first, optimization using the response surface method was implemented to obtain the highest yield of protein isolate from defatted hemp seed under different extraction conditions. Optimum extraction conditions were determined with 0% salt concentration, 12 pH value, and 49°C temperature. The protein isolate produced under optimum conditions was subjected to the glycation process, and the glycation conditions were also optimized. The optimum conditions for glycation were determined as a protein isolate: sugar ratio of 1.6:1, temperature of 60°C, and time of 90 min, providing the most suitable glycation degrees and browning indices. There was no statistical difference between the glycated protein isolate obtained under these conditions and the nonglycated protein isolate in terms of emulsifying activity index and emulsion stability index. For total phenolic–flavonoid compounds and antioxidant activity, the sugar complex caused a decrease in these values. In addition, there was a high positive correlation between bioactive compounds. SEM micrographs showed relationships between hemp seed protein isolate and sugar, and these interactions led to a spongy three-dimensional microstructure. When the FTIR results were analyzed, the glycated isolate had stronger absorption at 3300–3200 cm−1 compared to the nonglycated isolate. In conclusion, this study reports important findings in terms of functional and characteristic properties of how monosaccharides affect glycation.
AtıfScopus1WoS1İncele - MakaleAçık Erişim2025Scopus SJRQ1Anticancer (cytotoxic, anticlonogenic, antimetastatic, immunomodulatory actions) properties of 3,5-dibromosalicylaldehyde against glioblastoma cells and DFT analyses (FT-IR, Raman, NMR, UV) as well as a molecular docking study
Karakaş Sarıkaya, Ebru; Pehlivanoğlu, Suray; Türkmen, Merve Özcan; Ekincioğlu, Yavuz; Kostak, Feyza; Çelik, Sultan; Dereli, Ömer
Background Information: The primary objectives of this study were to characterize 3,5-dibromosalicylaldehyde (3,5-DBSA) and, investigate its antiproliferative, antimetastatic, cytotoxic, and immunoregulatory properties. NMR, Raman, UV, and FT-IR spectroscopies were used to characterize 3,5-DBSA. Potential conformations of 3,5-DBSA were evaluated using Spartan's MMFF method. Geometry optimization calculations using Gaussian software calculated conformation energy values. Results: Subsequently, Raman, FT-IR, UV (ethanol) and NMR (DMSO) parameters were calculated. The experimental spectrum was compared to theoretical spectroscopic data. The present investigation investigated 3,5-DBSA's anticancer properties; therefore, docking was done once the stable structure had been identified. Conclusion: Identifying stable structure is crucial to molecular docking studies. In order to identify the mechanism by which 3,5-DBSA binds to PI3K as a therapeutic target, molecular docking was utilized. This work is the first to show that 3,5-DBSA is cytotoxic, anticlonogenic, antimetastatic, and immunomodulatory in glioblastoma cell line U87MG compared to healthy fibroblast L929 cells. Cytotoxicity and anti-clonogenicity studies investigated 3,5-DBSA's antiproliferative activities, whereas wound healing assays assessed cell migration. The immunomodulatory effects of 3,5-DBSA in glioblastoma were assessed by measuring Netrin-1 and IL-6 protein levels. According to our findings, 3,5-DBSA may treat glioblastoma. Significance: This work analyzes 3,5-DBSA's conformational search, characterization, molecular docking, and structural and anticancer properties.
- MakaleAçık Erişim2025Scopus SJRQ2The Effect of Health Literacy Level of Caregivers of Individuals With Diabetes on Care Activities and Supportive Behaviours
Semerci Çakmak, Vahide; Akeren, Zahide; Sönmez Sarı, Ebru; Kalyoncuo, Servet
Background: To determine the effect of the health literacy levels of caregivers of individuals with T2DM on caregiving activities and supportive behaviours. Methods: Cross sectional study. The sample for the study comprised of people who provided care for 442 individuals who were diagnosed with diabetes. The data were collected using the Personal Information Form, HLS-14 and D-CASS. Descriptive statistics, Independent samples t test, One-Way ANOVA and multiple linear regression analysis were used to analyse the data. Results: According to the results of the multiple linear regression analysis, the model was found to be statistically significant, and the variables that were incorporated into the model were able to explain 68.1% of the variance. Among the variables included in the model, HLS-14, educational status, employment status, income status and diabetes-related education were found to affect the care activities and supportive behaviours of caregivers of individuals with diabetes. Conclusion: In the research, it was determined that care activities and supportive behaviours were higher in those with higher levels of HL, higher levels of education, those who were not employed, those with higher income levels, and those who received education about diabetes. Nurses should develop training programmes to increase the HL levels of caregivers.
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