Sürdürülebilir Kalkınma Amaçları

• 63
• 9
• 7
• 5
• 2
• 1
• 1
• 1

Alt birimler

• Anestezi Programı
• İlk ve Acil Yardım Programı
• Optisyenlik Programı
• Tıbbi Dokümantasyon ve Sekreterlik Programı
• Tıbbi Laboratuvar Teknikleri Programı

Araştırmacılar(24)

• Aksakallı, Ayhan
• Aksan, Nurcan Demircan
• Apaydın, Emine
• Arslan, Veysel
• Bayram, Sinan
• Can, Sümeyra
• Demircan, Nurcan
• Demirci, Emre
• Ekincioğlu, Yavuz
• Erdem, Özge
• Günaydınlı, Azime
• İçel, Merve Çarkıt
• Karadaş, Yasemin Ay
• Kaya, Alican
• Kızıl, Hamit Emre
• Köremezli, Ahmet
• Önal, Betul
• Sezer, Fatma
• Şenay, Volkan
• Tanrıverdi, Erdi Anıl
• Toğar, Başak
• Uzunçakmak, Sevgi Karabulut
• Yenigün, Baran
• Yücel, Harun

• MakaleYalnız künye2026Scopus SJRQ2/r/bayburt/10743
  Novel heteroaromatic compounds bearing thiosemicarbazone as anti-cancer and anti-bacterial agents: Synthesis, cytotoxic and biological screening, molecular docking and DFT analysis

  Nartop, Dilek; Ögütcü, Hatice; Özkan, Elvan Hasanoglu; Yetim, Nurdan Kurnaz; Kizil, Hamit Emre; Ekincioglu, Yavuz

  Novel heteroaromatic compounds (Hc1, Hc2, Hc3, Hc4) were obtained, and their structure were confirmed using various spectroscopic methods, including elemental analysis, fourier transform infrared (FT-IR) spectroscopy, proton and carbon nuclear magnetic resonance (1H/13C-NMR) spectroscopy, and molar conductance measurement. The biological activities of the heteroaromatic compounds against several Gram-positive (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Listeria monocytogenes ATCC 19111), and Gram-negative bacterial strains (Pseudomonas aeruginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteriae NCTC2966, Proteus vulgaris RSKK96026) were evaluated using the well-diffusion method. In general, the heteroaromatic compounds demonstrated a stronger inhibitory effect against Gram-positive bacteria. Hc1, Hc2 and Hc3 showed the highest inhibitory effect against B. cereus and L. monocytogenes. The compound (Hc4) showed the highest antibacterial activity and antifungal activity against Bacillus cereus and C. albicans, respectively. The cytotoxic activity of the heteroaromatic compounds was assessed against the non-small cell lung cancer cell line (NCI-H460) using the NutriCulture Cell Viability Detection Kit-8 (CVDK-8). Among the synthesized heteroaromatic compounds, Hc3 exhibited significant cytotoxic activity with an IC50 value of 141.3 & micro;g/mL, whereas compounds Hc1, Hc2, and Hc4 did not display significant toxicity at the tested concentrations. The molecular geometry of the heteroaromatic compound (Hc3) was optimized using Gaussian 09 W at the B3LYP/6-311++G (d,p) level of theory. Key structural parameters such as bond lengths, bond angles, and dihedral angles were determined through the same computational framework. Electronic features, including frontier molecular orbitals, global reactivity descriptors, and molecular electrostatic potential surfaces, were analyzed to explore intramolecular charge distribution and predict reactive sites. To evaluate the biological potential of the heteroaromatic compound (Hc3), molecular docking studies were performed. Additionally, drug-likeness assessment based on Lipinski's Rule of Five and ADME profiling revealed favorable pharmacokinetic characteristics. Molecular docking studies revealed that compound Hc3 showed a binding energy of -4.09 kcal/mol against the EGFR target (PDB ID: 1UWH), exhibiting key interactions such as hydrogen bonding and It-interactions with the active site residues. Based on all the results, it can be said that new heteroaromatic compounds have significant potential in the pharmaceutical field.

  • 
  AtıfScopus1·OpenAlex1

  İncele
• MakaleYalnız künye2026/r/bayburt/16789
  Chrysin as a multi-target regulator of tramadol-induced testicular damage: Integration of inflammation, mitochondrial dynamics, and germ cell survival pathways

  Erol, İ; Özdemir, S; Küçükler, S; Özkaraca, M; Akarsu, SA; Şimşek, H; Kızıl, HE; Mutlu, H; Kandemir, FM

  • 
  İncele
• MakaleAçık Erişim2026/r/bayburt/16029
  Thinking Through Russell’s Paradox: Logical, Epistemological, and Pedagogical Transformations in Pre-Service Teachers

  Aksakalli, Ayhan

  This study examines how the paradoxical structure of set theory introduced by Bertrand Russell affects the thinking skills and pedagogical awareness of pre-service teachers. Conducted within a qualitative research framework, the study involved 30 mathematics education students enrolled in the faculty of education at a public university. The participants engaged in a multilayered instructional process structured around Russell’s Paradox. Observation notes, individual reflection forms, group discussions, and focus group interviews were used as data collection tools, and the obtained data were analyzed through thematic analysis. The findings reveal that the paradox generated transformations in pre-service teachers at the levels of conceptual rupture, logical reorganization, and pedagogical awareness. It was observed that Russell’s Paradox became not only a theoretical logical construct but also a powerful learning tool that triggered epistemological inquiry. In this context, the study suggests that paradoxes may offer significant contributions to teacher education by fostering critical thinking, developing strategies for coping with contradiction, and supporting the construction of teacher identity.

  • 
  İncele
• MakaleYalnız künye2026Scopus SJRQ1/r/bayburt/14067
  Morin counteracts KBrO3-induced hepatotoxicity by reprogramming the HOTAIR/MEG3-miR-125b-5p/miR-214-5p axis and suppressing STAT1-associated RIPK3/MLKL necroptotic signaling

  Özer, Muhammed Rasit; Özdemir, Selcuk; Küçükler, Sefa; Özkaraca, Mustafa; Kizil, Hamit Emre; Akaras, Nurhan; Mutlu, Huseyin; Kandemir, Fatih Mehmet

  Potassium bromate (KBrO3; PB), an oxidative contaminant in ozonated water and bakery products, induces multi-mechanistic hepatotoxicity. Its epigenetic, necroptotic, and metabolic injury dimensions remain poorly characterized. Morin (MOR), a dietary flavonoid with established antioxidant and anti-inflammatory properties, has not previously been evaluated against PB-induced subacute hepatotoxicity. To characterize MOR's hepatoprotective mechanisms against PB-induced liver injury, focusing on the HOTAIR/MEG3-miRNA epigenetic axis, STAT1-associated RIPK3/MLKL necroptotic signaling, and Glut2/HPGD-AKT/mTOR metabolic signaling. Male Sprague-Dawley rats (n = 28) were assigned to Control, MOR (100 mg/kg), PB (62 mg/kg), and PB + MOR groups for 14 days. Outcomes included hepatobiliary biochemistry, oxidative stress markers, inflammatory mediators (ELISA), lncRNA/miRNA/mRNA profiling (RT-qPCR), immunohistochemistry (RIPK3, MLKL), double immunofluorescence (Glut2/AKT1; HPGD/mTOR), histopathology, and PCA. PB produced marked redox imbalance (up arrow MDA; down arrow SOD, CAT, GPx), NF-kappa B/NLRP3-associated inflammatory mediator elevation, epigenetic disruption (up arrow HOTAIR, down arrow MEG3; up arrow miR-125b-5p/down arrow BCL2L2; down arrow miR-214-5p/up arrow SMAD4), upregulation of STAT1-associated necroptosis-related transcripts and proteins (up arrow RIPK1/RIPK3/MLKL), and metabolic dysfunction (down arrow Glut2, down arrow HPGD; up arrow AKT1/mTOR). MOR restored redox balance, suppressed inflammation, and reprogrammed the miRNA axis while normalizing MLKL (transcript and immunohistochemistry) and AKT1 and partially attenuating RIPK3, mTOR, and STAT1. MOR confers multi-targeted hepatoprotection by restoring redox and metabolic homeostasis, attenuating NF-kappa B/NLRP3-associated inflammation, reprogramming HOTAIR/MEG3-miRNA epigenetics, and attenuating STAT1-associated RIPK3/MLKL signaling, supporting its potential as a dietary hepatoprotective candidate. PB is associated with engagement of the hepatic STAT1/RIPK3/MLKL axis and disrupts the HOTAIR/MEG3-miRNA network-both previously undocumented for this toxicant. MOR partially restores miR-214-5p/miR-466 expression while suppressing their downstream effector SMAD4, consistent with attenuation of pro-fibrotic signaling. Future work should employ multi-dose designs, in vitro mechanistic dissection, sex-stratified analyses, and clinical pharmacokinetic profiling to advance MOR toward translational application.

  • 
  İncele
• MakaleYalnız künye2026Scopus SJRQ2/r/bayburt/12800
  Sorting chiral active Brownian particles with radially modulated optical fields

  Yücel, Harun

  This study presents a numerical investigation of sorting chiral active Brownian particles using radially modulated optical fields. How these factors affect particle trajectories and spatial distributions is examined by systematically varying particle parameters such as self-propulsion speed, angular velocity, and optical fringe modulation. It is found that the average orbit radius of the particle trajectory strongly depends on the ratio of the self-propulsion speed to the average velocity induced by the moving fringe pattern. In particular, the average orbit radius converges to the theoretical orbit radius defined by the ratio of the self-propulsion speed to the angular velocity in the regime where the self-propulsion speed is greater than the fringe-induced velocity. In mixtures of particles with differing chirality, the dynamic response to circular fringe patterns enables effective classification based on motility. These findings suggest that structured light fields can be used to manipulate and selectively sort chiral active particles, which have potential applications in optical micromanipulation and active matter research.

  İncele
• MakaleAçık Erişim2026Scopus SJRQ1/r/bayburt/12794
  A natural nephroprotective adjuvant for cancer chemotherapy: Rosmarinic acid disrupts IL-17 A-Ferroptosis coupling in Ifosfamide-induced renal injury

  Süzen Celbek, Büşra; Şimşek, Hasan; Akaras, Nurhan; Kandemir, Özge; Kızıl, Hamit Emre; Mutlu, Hüseyin; Kandemir, Fatih Mehmet

  Rosmarinic acid (RA) is a natural polyphenol with established pleiotropic protective effects. Ifosfamide (IFA) is a potent antineoplastic agent whose clinical utility is severely limited by dose-dependent nephrotoxicity, primarily mediated by its metabolite, chloroacetaldehyde (CAA). This study aimed to investigate whether RA protects against IFA-induced nephrotoxicity and to elucidate the underlying molecular mechanisms. Male Wistar albino rats (n = 7 per group) were allocated into four groups: Control, RA-only (50 mg/kg, p.o., 2 days), IFA-only (a single 500 mg/kg, i.p. dose), and IFA + RA. Serum biochemical markers (urea, creatinine), renal oxidative stress parameters (MDA, GSH, SOD, CAT, GPx), gene expression levels (NF-κB, TNF-α, IL-1β, IL-17 A, ACT1, TRAF6, Caspase-3, Bax, Bcl-2, PTGS2, GPX4, TfR1), and histopathological/immunohistochemical analyses (KIM-1, Nephrin, Caspase-3) were performed 24 h post-administration. IFA induced severe renal dysfunction, marked oxidative stress, and extensive histopathological damage. Mechanistically, IFA initiated a pathogenic cascade activating intrinsic apoptosis and ferroptosis, driven by a self-sustaining IL-17 A-TRAF6-NF-κB inflammatory loop. RA co-treatment (50 mg/kg) significantly reversed all functional, biochemical, and histological damage by strategically breaking this crosstalk, restoring redox homeostasis, and simultaneously restraining both cell death programs. In conclusion, RA protects against IFA nephrotoxicity by targeting the critical inflammation-ferroptosis coupling, positioning it as a highly promising adjuvant candidate for clinical use to mitigate IFA-induced renal injury.

  • 
  AtıfScopus3·WoS4·OpenAlex6

  İncele
• MakaleAçık Erişim2026Scopus SJRQ1/r/bayburt/12696
  Nurses’ Workplace Discrimination Experiences and Their Reflections on Career Development: A Qualitative Study

  Koroglu Kaba, Nagihan; Apaydin, Emine; Kulakaç, Nurşen

  Aim: This study was conducted to examine how nurses experience discriminatory behaviors in the workplace and how these experiences are reflected in their career development. Background: Although discrimination constitutes a significant challenge in nurses’ professional lives, qualitative research examining how these experiences influence their career development processes remains limited. Methods: This phenomenological study was conducted with nurses working in a public hospital in Turkey. Semi-structured individual interviews were conducted with 21 nurses during the study. Participants were selected from various clinical settings through purposive sampling. Data were analyzed using Colaizzi's seven-step content analysis method. Ethics committee approval was obtained for this study. The Consolidated Criteria for Reporting Qualitative Research checklist guided the study reporting. Results: Five main themes with seven subthemes emerged: (1) Discrimination Experiences (types of discrimination, sources of discrimination, emotions/feelings), (2) Reporting Behavior (decision and consequences of reporting, reasons for not reporting), (3) Impact of Discrimination on Career Development (supportive effect, hindering effect), (4) Coping Strategies, and (5) Suggestions for Preventing Discrimination. Discussion: These themes highlight that discrimination is a multidimensional phenomenon and that holistic approaches must be developed at emotional, structural, professional, and institutional levels to cope with it. Conclusion: For some nurses, discrimination acts as a transformative process that supports career development, while for others, it represents a significant barrier to professional advancement. Implications for Nursing/Nursing Policy: The findings highlight the need to strengthen reporting mechanisms, establish a supportive work culture, and implement inclusive institutional policies that promote career development.

  • 
  • 
  • 
  AtıfScopus1·OpenAlex1

  İncele
• MakaleAçık Erişim2026Scopus SJRQ2/r/bayburt/12687
  Physical, chemical and thermal characterization of bacterial nanocellulose produced using sugar beet molasses by Komagataeibacter sp. SB2569

  Kara, Adem; Bayram, Sinan

  Bacterial nanocellulose (BNC) is a biopolymer synthesized by bacteria utilizing various carbon sources. The biocompatible and biodegradable nature of BNC offers considerable advantages for its application in fields such as medicine, biomedical engineering, cosmetics, food, nanocomposites, and organoelectronics. Nevertheless, the high production costs necessitate the development of more cost-effective and efficient BNC production methodologies. This study aimed to produce BNC utilizing cost-effective sugar beet molasses. To achieve this, bacteria isolated from various vinegar samples were assessed, revealing that the BNC production potential of these isolates ranged from 2.09 to 3.21 g L⁻1. The 16S rDNA gene of the strain with the highest BNC yield was amplified and sequenced, and it was subsequently deposited in the GenBank database as Komagataeibacter sp. SB2569, with the accession number PV231799.1. XRD analysis revealed characteristic diffraction peaks at 14.8°, 16.5°, 22.6°, and 34.5°, confirming the cellulose 1β crystalline structure and high crystallinity of the synthesized BNC. FTIR analysis exhibited characteristic absorption bandsthat, confirming the presence of β-1,4-glycosidic linkages and the cellulose I structure of BNC. TGA analysis showed an initial weight loss of ~ 5% between 0–100 °C, a major degradation of ~ 75% occurring at 220–350 °C with a maximum decomposition rate at 343 °C, and a residual mass of approximately 10–20% remaining above 600 °C. The findings indicate that the Komagataeibacter sp. SB2569 strain holds significant potential for BNC production using low-cost carbon sources.

  AtıfScopus1·WoS1·OpenAlex2

  İncele
• MakaleAçık Erişim2026Scopus SJRQ1/r/bayburt/12661
  Associations between technology use, perceived burdensomeness, and independence among rural older adults

  Bal, Betül; Apaydin, Emine

  Objective: This study aims to examine the relationships among perceived burdensomeness, technology use habits, and activities of daily living (ADL) in older adults residing in rural areas. Methods: This descriptive correlational study was conducted with 384 older adults living in rural areas in two different regions of Turkey. Data were collected using an Information Form, the Geriatric Perceived Burdensomeness Scale, the Barthel Index for Activities of Daily Living, and the Technology Use Habits Scale. Results: Perceived burdensomeness was moderately and negatively correlated with ADL (r = − 0.484, p < 0.001), whereas technology use habits were weakly but positively correlated with BADL (r = 0.192, p < 0.001). In the hierarchical regression analysis, technology use habits showed a positive and statistically significant association with ADL in the initial model (β = 0.189, p < 0.001). When perceived burdensomeness was added to the model, it emerged as a strong negative predictor of ADL (β = −0.497, p < 0.001), substantially increasing the explained variance. In the fully adjusted model, perceived burdensomeness, age, digital device use, and duration of digital device use were significantly associated with ADL, whereas age did not significantly affect the relationship between perceived burdensomeness and ADL. Overall, perceived burdensomeness and technology use habits were identified as key factors related to functional independence among rural older adults. Conclusion: The findings of this study indicate that perceived burdensomeness and technology use habits are closely associated with independence in activities of daily living among older adults living in rural areas. These findings indicate an association between technology use and perceived burdensomeness and provide a foundation for future research in nursing practice and rural health services. Future research is recommended to focus on evaluating technology-based and psychosocial interventions that support independence and psychosocial well-being in rural older populations. Clinical trial number: Not applicable.

  • 
  İncele
• MakaleYalnız künye2026Scopus SJRQ1/r/bayburt/12641
  Molecularly engineered bacterial biopolymer as multifunctional interfacial regulators for dendrite-free and stable aqueous zinc-ion batteries

  Adhami, Sadaf; Bayram, Sinan; Coskun, Sahin; Sonmezoglu, Savas; Yuksel, Recep

  Aqueous zinc-ion batteries (ZIBs) are promising candidates for next-generation energy storage owing to their intrinsic safety, low cost, and high theoretical capacity. However, their practical application remains hindered by dendrite formation and parasitic side reactions such as hydrogen evolution reaction (HER), anode corrosion, and passivation. Herein, we introduce a sustainable and scalable strategy based on a bacterial eumelanin biopolymer (S2–20), synthesized via the oxidative metabolism of Pseudomonas aeruginosa with indole derivatives, and directly deposited onto Zn foil via spin coating. The S2–20 biopolymer provides a conformal, ion-permeable interface that simultaneously guides uniform Zn nucleation, enhances electrolyte wettability, and suppresses parasitic side reactions. Symmetric cells demonstrate significantly increased Zn2+ transference number (0.908), and prolonged cycling stability exceeding 1200 h at 1.0 mA cm−2 and 200 h under harsh conditions up to 20 mA cm−2. Full cells with V2O5 cathodes further confirm remarkable specific capacity (374 mAh g−1 at 1.0 A g−1) and capacity retention, maintaining 150.5 mAh g−1 after 2200 cycles at 1.0 A g−1. This work presents the first demonstration of a bacterial eumelanin biopolymer as a multifunctional interfacial stabilizer for Zn metal, offering a truly green, cost-effective, and scalable pathway toward safe and sustainable aqueous ZIBs.

  • 
  AtıfOpenAlex1

  İncele