Sürdürülebilir Kalkınma Amaçları

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Araştırmacılar(2)

• İçel, Merve Çarkıt
• Uzunçakmak, Sevgi Karabulut

• MakaleAçık Erişim2025/r/bayburt/14181
  Does Lrig1 expression have a relationship with ERBB1 and ERBB2 expression in schizophrenia?

  Uzunçakmak, Sevgi Karabulut; Özcan, Halil; Aydin, Pelin; Halici, Zekai

  Purpose: This study aims to investigate Lrig1 expression and to reveal the possible relationship between Lrig1, ERBB1 and ERBB2 in schizophrenia. Materials and Methods: In this study, peripheral blood samples of 70 schizophrenia patients and 60 healthy controls were used. Real Time PCR was applied for Lrig1, ERBB1 and ERBB2 gene expression analysis. Results: The level of Lrig1 mRNA was lower in the patients when compared to healthy controls. Expression levels of ERBB1 and ERBB2 were decreased in the patients versus in the healthy controls. According to the receiver operating characteristic curve analysis, the three genes had the power to discriminate the patients from the ERBB1 and ERBB2 expressions in the patients. in schizophrenia.

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  İncele
• MakaleAçık Erişim2024Scopus SJRQ3/r/bayburt/10885
  Unveiling the significance of Gremlin-1 as a novel biomarker for enhanced severity prediction in COVID-19 patients

  Celik, Muhammet; Tekin, Erdal; Koçak, Mehmet Nuri; Uzunçakmak, Sevgi Karabulut; Bayraktar, Mustafa

  Gremlin-1 is associated with lung disease and plays a role in the initiation and progression of pulmonary fibrosis. This suggests that Gremlin-1 may be associated with lung involvement in COVID-19 and poor clinical outcomes and warrants further investigation. This prospective, cross-sectional, single-blind study was the first to investigate Gremlin-1 levels in COVID-19 patients and whether Gremlin-1 levels could be used to predict and guide clinical follow-up in outpatients and inpatients. In this context, serum Gremlin-1 levels were measured and compared in 2 groups of patients who were diagnosed as positive for COVID-19 by RT-PCR and were followed up as outpatients (n = 28) or required hospitalization (n = 30). The median Gremlin-1 values were statistically significantly different between outpatients and intensive care unit patients (0.367 ng/mL [IQR = 0.377], 1.858 ng/mL [IQR = 2.245], respectively) (P < .0001). The area under the ROC curve value to determine the discriminative power of Gremlin-1 was found to be 0.772 (95% CI: 0.672-0.871; P < .0001), and the cutoff value of Gremlin-1 to discriminate between outpatients and hospitalized patients was found to be 1.242 ng/mL with 66.7% sensitivity and 67.2% specificity. Serum Gremlin-1 level is an important biomarker that can be used as a clinical decision-making tool for COVID-19 positive patients.

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  AtıfScopus2·WoS2·OpenAlex3

  İncele
• MakaleAçık Erişim2023/r/bayburt/15685
  The effect of boric acid, calcium fructoborate and potassium boron citrate on bone health in rats

  Uzunçakmak, Sevgi Karabulut

  The aim of this study was to examine the effects of boron varieties on bone health. For this purpose, twenty-four wistar rats were used. Animals were separated into four groups. The first group was the control group and was treated with nothing. The other three groups were given 3mg/kg boric acid (BA), calcium fructoborate (CaFB) and potassium boron citrate (KBCi) orally by gavage for three weeks. TNF-α, IL1-β, total oxidant level (TOS), total antioxidant level (TAS), osteopontin and osteocalcin levels were measured in serum and bone tissues of animals by ELIZA method. In the results of the study, no significant difference was observed in serum and bone tissue TNF-α and IL-1β levels between the control group and the groups that were treated with boron varieties were applied (p&gt;0.05). Similarly, serum and bone TOS levels did not differ significantly between the control and other groups (p&gt;0.05). However, the serum TAS level increased significantly with the application of BA, CaFB and KBCi in both serum and bone tissue compared to the control (p&lt;0.0001). Serum osteopontin and osteocalcin levels were also significantly increased with the application of BA, CaFB and KBCi, especially in bone tissue, compared to the control group (p&lt;0.0001). The effects of BA, CaFB, and KBCi on bone health have been compared with this study, firstly. This study is promising as a preliminary study for more comprehensive studies to be carried out in order to use boron varieties such as BA, CaFB and KBCi more widely in the future in order to improve bone health, prevent bone diseases or cope with increased stress due to various factors

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  AtıfOpenAlex2·TR Dizin2

  İncele
• MakaleAçık Erişim2023/r/bayburt/14329
  LRIG1 levels in chronic rhinosinusitis with nasal polyps

  Uzunçakmak, Sevgi Karabulut; Sahin, Abdulkadir; Özçelik, Aysegul Tavaci; Halici, Zekai

  Purpose: Nasal polyps (NPs), usually occurring together with chronic rhinosinusitis (CRS), are benign masses of mucosal origin arising from inflammation. The transmembrane protein known as leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) is a member of the Lrig family. Lrig1 is frequently expressed in the respiratory tract and epithelial tissues and can inhibit several signaling pathways involved in cell proliferation. The aim of this study was to determine Lrig1 levels in NP tissues of patients with CRS. Material and Methods: This study included 36 patients with CRS and NPs and 15 patients who underwent rhinoplasty as the control group. The Lrig1 levels of all participants were measured by the ELISA method.Results: This study revealed that Lrig1 levels were significantly lower in NP tissues than in tissues of the control group. The mean level of Lrig1 of the NP tissues was 22.2 ng/ml, while the mean level of the control group was 28.5 ng/ml. According to the results of ROC analysis, Lrig1 levels have the power to distinguish polyp tissues from control tissues (AUC=0.794). Lrig1 levels were higher in tissues with scores of 4-8 than in tissues with scores of 16-20 based on the results of computed tomography scoring. According to endoscopic evaluations, Lrig1 levels of tissues with scores of 5-8 or 9-11 were relatively lower than those of tissues with scores of 2-4.Conclusion: Lrig1 levels were found to be decreased in NP tissues. Thus, Lrig1 may be used to confirm the presence of NPs. Lrig1 may also be helpful in NP grading. Increasing the Lrig1 levels in cases of NPs has the potential to become a targetable treatment modality.

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  AtıfWoS1·OpenAlex1·TR Dizin1

  İncele
• MakaleAçık Erişim2022Scopus SJRQ3/r/bayburt/12053
  Comparison of Serum Adropin Levels in Patients with Diabetes Mellitus, COVID-19, and COVID-19 with Diabetes Mellitus

  Aydın, Pelin; Karabulut Uzunçakmak, Sevgi; Tör, İbrahim Hakkı; Bilen, Arzu; Özden, Ayşe

  Objective: In the present study, the relationship between a poor prognosis and adropin levels in diabetic patients with coronavirus disease 2019 was investigated by measuring serum adropin levels and levels of D-dimer, C-reactive protein, and ferritin, which are considered prognostic factors for coronavirus disease 2019. Materials and Methods: Hundred volunteer participants treated in the Erzurum Regional Training and Research Hospital were included in this study. Serum adropin levels were measured by enzyme-linked immunosorbent assay. The relationship between serum adropin level and C-reactive protein, ferritin, and D-dimer levels was analyzed by correlation analysis. Results: The participants’ serum adropin levels differed between the groups (P =.0007). The control group had the highest adropin levels among groups. The lowest adropin levels were in the COVID + diabetes mellitus group. Adropin levels of diabetes mellitus, COVID, and diabetes mellitus + COVID groups were significantly decreased when compared to the control (P <.05). There was a significant negative correlation between adropin and C-reactive protein, D-dimer, and ferritin. Conclusion: Adropin can be used as an auxiliary biomarker, a prognostic factor in the early management of coronavirus disease 2019 patients with diabetes mellitus. We think that our study will guide future studies conducted in this field.

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  AtıfScopus9·WoS10·OpenAlex13·TR Dizin3

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