Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Akmeşe, Osman(3)
- Aygül, İmdat(3)
- Baltacı, Cemalettin(3)
- Fidan, Muhammed Said(3)
- Sefalı, Abdurrahman(3)
- Öz, Mehmet(3)
- Bayram, Nesrin Ecem(2)
- Kırkıncı, Seran(2)
- Bakirci, Ihsan(1)
- Bastürk, Fatma Nur(1)
- Bayram, Ozkan(1)
- Bayram, Sinan(1)
- Baştürk, Fatma Nur(1)
- Boztas, Kadir(1)
- Can, Zehra(1)
- Canlı, Deniz(1)
- Deniz, Ilhan(1)
- Gercek, Yusuf Can(1)
- Gerçek, Yusuf Can(1)
- Gıdık, Betül(1)
- Kaban, Güzin(1)
- Kaya, Mükerrem(1)
- Kiliç, Ali Osman(1)
- Kösesakal, Taylan(1)
- Macit, Emine(1)
- Mavaldi, Muhammed Halid(1)
- Simsek, Onder(1)
- Tabbouche, Sana(1)
- Yesil, Yeter(1)
- Yilmaz, Bilge(1)
- Yıldırım, Nazlıcan(1)
- Yılmaz, Özlem(1)
- Çaglar, Abdullah(1)
- Çelik, Saffet(1)
- Öz, Gül Cevahir(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ3Chemical Profiling of Stachys cretica subsp. anatolica Rech. f. (Endemic) Essential Oils and their Methanol Extracts with Evaluation as Enzyme Inhibitors, Antioxidant, and Antimicrobial Agents
Öz, Mehmet; Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman; Aygül, İmdat
Enzyme inhibition activities, phenolic compounds, antioxidant activities, bioactive compounds, antimicrobial activities, and chemical components of essential oil and methanol extracts obtained from the aerial parts of S. cretica subsp. anatolica were investigated. The main phenolic compounds of aerial parts were catechin, oleuropein, and epicatechin. The determined enzyme inhibitor activities highlight the potential of S. cretica subsp. anatolica as a source of bioactive compounds, particularly for carbonic anhydrase and cholinesterase inhibition. The essential oil and methanol extract exhibited remarkable activities against CA-II, AChE, and BChE, although they were less potent than standard inhibitors. The essential oils generally showed stronger antimicrobial activity compared to the 30% methanol extracts across most bacterial and fungal strains, as evidenced by minimum lethal concentration (MLC) and lower minimum inhibitory concentration (MIC) values and larger inhibition zones. Chloramphenicol used alone exhibited the highest antimicrobial efficacy, with the lowest MIC and MLC values and the largest inhibition zones. The essential oils of S. cretica subsp. anatolica were determined as esters, oxygenated sesquiterpenes, and aldehydes in aerial parts. The main components were found to be hexahydrofarnesyl acetone in the aerial parts.
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İncele - MakaleAçık Erişim2026Scopus SJRQ3Chemical Profiling and Biological Activities of Methanol Extracts and Essential Oils From Ferulago Platycarpa Boiss. & Balansa (Endemic): Enzyme Inhibition, Antioxidant, and Antimicrobial Properties
Aygül, İmdat; Öz, Mehmet; Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman
This study aimed to evaluate the phytochemical composition and biological activities of Ferulago platycarpa methanol extract (ME) and essential oil (EO). The EO was obtained via hydrodistillation and analyzed by GC-MS, revealing sesquiterpene hydrocarbons as the dominant class, with caryophyllene (65.8%) and α-pinene (9.65%) as the major constituents. The methanol extract was subjected to LC-MS/MS analysis, which identified eleven phenolic compounds, with chlorogenic acid as the most abundant. The extract showed significantly higher total phenolic (1196.22±11.64 mg GAE/100g) and antioxidant (1870.00±17.69 mg QEE/100g) contents compared to the ME. In vitro enzyme inhibition assays demonstrated that the methanol extract exhibited potent inhibitory activity against carbonic anhydrase II (CA-II, ICSO= 0.023 pg/mL), acetylcholinesterase (AChE, ICSO= 110 pg/mL), and butyrylcholinesterase (BChE, IC50= 390 pg/mL). In contrast, the EO showed higher inhibition against α-amylase (IC50= 5920±10.45 pg/mL) and BChE (IC50= 1.32±0.65 pg/mL), while its α-glucosidase showed no inhibition. Antioxidant assays indicated superior activity for the methanol extract compared to the EO. Furthermore, antimicrobial testing revealed that the EO demonstrated broader and more effective antimicrobial action, exhibiting lower MIC and MBC values against several bacterial and fungal strains. Collectively, these results highlight F. platycarpa as a valuable source of bioactive compounds with promising applications in antidiabetic, neuroprotective, antioxidant, and antimicrobial therapies.
- MakaleAçık Erişim2025Scopus SJRQ3Chemical composition of essential oils and comparative analysis of enzyme inhibitory, antioxidant and antimicrobial activities in essential oils of endemic Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N. Kilian
Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman; Aygül, İmdat; Öz, Mehmet
In this study, essential oil from the aerial parts of Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N. Kilian was extracted via hydrodistillation using a Clevenger apparatus. GC-MS/FID analysis determined aldehydes (28.31%) as the dominant group, with eucalyptol (8.71%) as the main constituent. Antioxidant activities were exhibited using DPPH, ABTS, and FRAP assays, with the essential oil demonstrating relatively higher antioxidant properties. The essential oil also showed higher levels of bioactive components, including total antioxidant capacity (160.26 mg AA eq./100 mL), total phenolic content (21.57 mg GA eq./100 mL), and total flavonoid content (14.85 mg QE eq./100 mL). While G. sericea essential oil demonstrated some antioxidant activity, it was significantly lower compared to the reference standard ascorbic acid (AA). The antimicrobial results showed relatively higher antimicrobial activity compared to most bacterial and fungal strains, as evidenced by lower MIC and MBC values and larger inhibition zones. Nevertheless, chloramphenicol (CH) and nalidixic acid (NA) continually showed superior antimicrobial efficacy, with the lowest MIC and MBC values and the largest inhibition zones. The essential oil also demonstrated potent enzyme inhibitory activity, especially against CA-II, AChE, and BChE, with the lowest IC50 value observed for CA-II, highlighting its potential as a potent enzyme inhibitor. However, the essential oil exhibited comparatively greater inhibition against AChE, BChE and α-amylase but was less effective overall. These findings suggest that the G. sericea essential oil has important antioxidant potential and enzyme inhibitory activity, while the essential oil shows varying efficacy across different enzymes.
AtıfOpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ1The Effects of Essential Oils from Coriander Seed, Tarragon and Orange Peel on Lipid Production by Yarrowia lipolytica Strains
Yılmaz, Özlem; Kaban, Güzin; Kaya, Mükerrem
The aim of the study was to investigate the effects of different concentrations (0.15, 0.30, and 0.45 mL/L) of essential oils from coriander seeds (Coriandrum sativum), tarragon (Artemisia dracunculus), and orange peels (Citrus sinensis) on biomass, lipid content, and lipid yield of the strains Yarrowia lipolytica Y-1094, Y. lipolytica YB 423, and Y. lipolytica IFP29. The fatty acid composition of the oils produced by the strains was also determined. The highest biomass (5.38 ± 1.80 g/L) and lipid production (0.98 ± 0.42 g/L) were observed in the presence of Y. lipolytica IFP29 and Y. lipolytica YB 423, respectively. The lipid yield showed the highest value at the level of 0.45 mL/L in the presence of the Y. lipolytica Y-1094 strain. The correlation heat map results indicate that 0.45 mL of tarragon affected biomass and lipid content more than the other essential oils used. Y. lipolytica Y-1094 produced higher levels in terms of myristic acid and palmitic acid in all three essential oil sources than the other strains. The highest oleic acid level of all strains was determined in coriander seed essential oil, and the lowest in tarragon essential oil. The oleic acid level of Y. lipolytica Y-1094 was lower than that of the other two strains in all essential oils. Regarding linoleic acid, the oil level did not have a significant effect in the presence of tarragon and orange peel.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2024Investigation of Some Tree Bark Extracts and Essential Oils for Antioxidant, Antimicrobial and Anti-Quorum Sensing Activities
Yilmaz, Bilge; Tabbouche, Sana; Deniz, Ilhan; Kiliç, Ali Osman; Can, Zehra
Aim of study: The objective of this research is to uncover the bioactive characteristics of ethanol extracts and essential oils from 15 different tree barks (Thuja plicata, Sequoia sempervirens, Eucalyptus globulus, Pinus nigra, Platanus orientalis, Fagus orientalis, Populus tremula, Castanea sativa, Pinus sylvestris, Pinus pinaster, Picea orientalis, Populus nigra, Cryptomeria japonica, Abies nordmanniana, Quercus robur). Material and method: In this study, the bioactive properties of 15 different tree barks were investigated. Ethanol extracts were analyzed for their polyphenolic content, antioxidant activity, and antimicrobial properties. Additionally, the essential oils were evaluated for their anti-quorum sensing capabilities. Main results: Several barks demonstrated high potential as sources of polyphenolic compounds, tannins, and antioxidant activity, indicating their potential as bioactive resources for the forestry and pharmaceutical industries. Research highlights: The ethanol extracts of Eucalyptus globulus, Castanea sativa, and Quercus robur barks showed remarkable results regarding total polyphenolic content, antioxidant activity, and antimicrobial properties. Essential oils from the barks of Populus nigra, Populus tremula, and Platanus orientalis exhibited positive anti-quorum sensing activity. Moreover, both Quercus robur and Eucalyptus globulus displayed high bioactive potential.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ1Evaluation of lavender essential oils and by-products using microwave hydrodistillation and conventional hydrodistillation
Kırkıncı, Seran; Gercek, Yusuf Can; Baştürk, Fatma Nur; Yıldırım, Nazlıcan; Gıdık, Betül; Bayram, Nesrin Ecem
This study investigated the impact of two extraction methods, traditional hydrodistillation (TDH) and microwave-assisted hydrodistillation (MAH), on the essential oil yield and chemical profile of Lavandula angustifolia L., as well as the bioactive potential of the resulting wastewater. Essential oil composition was analyzed via GC–MS, revealing similar qualitative and quantitative profiles for both methods, with α-terpinolene and (–)borneol as major constituents. Wastewater analysis via LC–MS/MS and spectrophotometric assays demonstrated the presence of significant total phenolic content (3.29–1.78 mg GAE/g) and 32 individual phenolics (463.1 µg/kg for TDH; 479.33 µg/kg for MAH). These findings suggest that both essential oil and wastewater obtained by either method possess considerable bioactive potential, with the MAH method potentially offering advantages over TDH for essential oil extraction. Further exploration of wastewater applications in various industrial sectors is warranted.
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İncele - MakaleAçık Erişim2022Scopus SJRQ2Characterization of Essential Oil and Wastewater from Thymus nummularius M. Bieb. and Micromorphological Examination of Glandular Trichomes
Gerçek, Yusuf Can; Bayram, Sinan; Çelik, Saffet; Canlı, Deniz; Mavaldi, Muhammed Halid; Boztas, Kadir; Bastürk, Fatma Nur; Kırkıncı, Seran; Yesil, Yeter; Kösesakal, Taylan
This study aimed to determine the volatile profile by GC-MS and antimicrobial activity of the essential oil isolated from Thymus nummularius using the microwave-assisted hydrodistillation method and morphologically characterize the glandular trichomes in leaf samples. Obtained essential oil, as well as wastewater obtained during essential oil isolation, were chemically (polyphenolic compounds, organic acids, total phenolic content, total flavonoid content and antioxidant activity) characterized. As a result of GC-MS analysis of the essential oil, different ratios of essential oil components were identified, predominantly thymol (38.91%), linalool (13.12%) and geraniol (6.51%). The antimicrobial activity results showed that T. nummularius essential oil has a broad-spectrum inhibitory effect against all target microorganisms (bacteria and yeast-like fungi). Screening of 32 polyphenolic compounds and 52 organic acids in the wastewater was performed by LC-MS/MS and the major polyphenolic compound and organic acid were determined as caffeic acid (97316.85 µg/kg) and malic acid (6898.88 mg/kg), respectively. While the total phenolic and flavonoid content of the wastewater were 35.91 mg GA/g and 34.91 mg QE/g, respectively, the antioxidant activity results were obtained using the CUPRAC, CERAC and ABTS tests were 86.28 mg TE/g, 72.85 mg TE/g and 47.88 mg TE/g. These results support that the T. nummularius, an important production area in Turkey, can be used in different industrial areas due to its rich bioactive content. In addition, it can be said that wastewater is also considered a valuable source of bioactive substances.
AtıfScopus11WoS8OpenAlex11İncele - MakaleAçık Erişim2018Scopus SJRQ2A study on the optical, chemical and dielectric properties of PPCIN thin films derived from essential oil compounds using RF plasma polymerisation technique
Bayram, Ozkan; Simsek, Onder
Polymer-based nanostructured films were produced on various substrates using Radio Frequency (RF) plasma polymerization technique from Cinnamaldehyde monomer which is an organic compound. To fabricate polymer thin film, the pressure, the deposition time and RF power were set to 480 mTorr, 30 min and 15, 20 and 30 W, respectively. The effect of RF power on the optical, morphological and chemical properties of thin films were investigated. The optical, morphological and chemical properties were determined by UV–Vis spectroscopy, Atomic Force Microscopy (AFM) and FTIR spectroscopy, respectively. The average surface roughness of thin films was detected as 5.7 nm, 3.9 nm and 11.7 nm using AFM depending on the increase in RF power. Using FTIR spectroscopy, the chemical structure of the polymer thin films was compared with that of the monomer material, and it was found that the majority of the functional groups belonging to the monomers also appeared in the thin films. Optical band gap of thin films increased with RF power and these values were determined as 2.83 eV, 3.05 eV and 2.98 eV, respectively. The extinction coefficients and refractive indices of the thin films were measured at 500 nm between 0.00183–0.00522 and 2.40–2.78, respectively.
AtıfScopus14WoS14OpenAlex16İncele - MakaleAçık Erişim2017The Possibilities of Using Some Spice Essential Oils in Ice Cream Production
Macit, Emine; Çaglar, Abdullah; Bakirci, Ihsan
In present study, some physical, chemical, sensory and microbiological characteristics of ice cream samples produced by using 4 different essential oils (Coconut, lemon bark, clove and cinnamon) in 2 different levels (0.2% and 0.4%) were investigated. The findings indicated that although the addition of essential oil was not significantly effective on the physical and chemical properties of ice cream samples (P>0.05), the melting rates increased during storage. The sample with 0.2% coconut essential oil was the most favorite sample in sensory evaluations, while the sample with 0.4% clove essential oil was the least favorite sample. In general, samples with 0.2% essential oil were more appreciated than samples with 0.4%. It has been determined that ice cream samples conformed to TS 4265 Ice Cream Standard (Turkish Standard) in terms of microbiological properties. With this study, it was determined that some essential oils can be used as a natural aroma substance in the production of ice cream.
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