Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Öztürk, Mesut(3)
- Arici, Faruk(2)
- Cuce, Erdem(2)
- Cuce, Pinar Mert(2)
- Dirican, Ebubekir(2)
- Eryılmaz Türkkan, Gökçen(2)
- Guclu, Tamer(2)
- Hırca, Tuğçe(2)
- Kızıl, Hamit Emre(2)
- Tayfur, Bilal(2)
- Ada Yıldız, Kübra(1)
- Afshari, Faraz(1)
- Artar, Musa(1)
- Aydin, Tuba Ağirman(1)
- Ayna, Adnan(1)
- Bacaksız, Efsun(1)
- Bilgin, MH(1)
- Bilgin, Yusuf(1)
- Bouabidi, Abdallah(1)
- Caglayan, Cuneyt(1)
- Can, U(1)
- Ceviz, Mehmet Akif(1)
- Danis, H(1)
- Darendelioğlu, Ekrem(1)
- Demir, E(1)
- Ekincioğlu, Yavuz(1)
- El Hadi Attia, Mohammed(1)
- Erdem, Cahit(1)
- Ergin, Ayda Nur(1)
- Ergün, Mustafa(1)
- Güllü, Eda(1)
- Gümüş, Recep(1)
- Güneş, Erdi(1)
- Gür, Cihan(1)
- Güven Akdeniz, Dilşad(1)
- Gıdık, Betül(1)
- Halıcı, Zekai(1)
- Kandemir, Fatih Mehmet(1)
- Kara Dilek, Zuhal Elif(1)
- Kara, Adem(1)
Yayınlar
- MakaleYalnız künye2026Scopus SJRQ1How to conceptualize the equal sign by middle school students?
Türk, Adem; Öztürk, Mesut
This research examined middle school grade 5–8 students’ conceptualization of the equal sign. The study employed a cross-sectional approach. Eight middle school students studying in official public schools in Turkey participated in the study. The study’s data were collected through a clinical interview that utilized eight open-ended questions, covering topics such as arithmetic, pre-algebra, proportional relationship, and algebra. Thematic analysis was used to analyze the study data. Although previous studies showed that students saw the equal sign as write a result, the results of this research, which is a follow-up study, revealed that students did not think of the equal sign as write a result.
- MakaleYalnız künye2026Scopus SJRQ2Experimental investigation on hybrid parabolic trough collector and thermoelectric generator system for energy, economic, and environmental aspects
Cuce, Pinar Mert; Guclu, Tamer; Cuce, Erdem; Bouabidi, Abdallah; El Hadi Attia, Mohammed
This study experimentally investigates the thermal and electrical performance, economic feasibility, and environmental impacts of a hybrid energy system integrated with a parabolic trough collector (PTC) and thermoelectric generator (TEG). In the established system, solar energy is converted into electrical and thermal energy using a steam turbine and TEG. Experimental data indicate that the system operates with an average efficiency of 71.44%, which varies depending on the intensity of solar radiation. The overall energy efficiency of the system is calculated as 14.51%. In the economic analysis, the payback period of the designed system is approximately 5.4 years, while the levelised cost of energy production (LCOE) is calculated to be 0.075 USD kWh−1. The environmental assessment indicates that the system can prevent 356.18 kg of CO2 emissions annually and save approximately 1499.72 L of water. These findings demonstrate that hybrid systems offer an economically and environmentally sustainable and efficient alternative to energy production.
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İncele - MakaleAçık Erişim2026Scopus SJRQ2Investigation of the Effects of Low-Temperature Thermal Treatment Applied to Graphite in Spent Lithium-Ion Anode Recycling
Kara, Adem; Temur, Hakan
As the use of lithium-ion batteries (LIB) increases rapidly, recovery of graphite, the main component of the anode, from spent batteries has become important from environmental and economic perspectives. In this study, an acid leaching step followed by thermal treatment under partial atmosphere at a relatively low calcination temperature was investigated to recover graphite from spent lithium-ion batteries. The molecular and chemical structures of the recovered graphite in all spent anode samples were investigated using FTIR, ICP-MS, XRD, SEM–EDX and TEM–EDX. It was observed that organic impurities and volatile components were largely removed after acid leaching and thermal treatment at 750 °C. In addition, it was observed that graphite layers were rearranged and the distance between the layers decreased under the effect of thermal treatment. Partial atmosphere calcination at 750 °C can be considered as a feasible method for graphite recovery, offering energy efficiency and scalability. However, in an efficient calcination, it is necessary to maintain controlled oxygen levels to prevent excessive graphite loss and to perform preliminary acid leaching to reduce metal impurities. In order to best recycle graphite in waste lithium-ion anode recovery, a balance must be achieved between temperature, energy efficiency and material recovery. Considering this balance, a calcination temperature of 750 °C appears to be preferable for recycling.
AtıfScopus2WoS2İncele - MakaleAçık Erişim2026Scopus SJRQ1Structural condition assessment of the Bamsı Beyrek observation terrace in Bayburt, Türkiye, on autonomous updated FEMs
Ergün, Mustafa; Tayfur, Bilal; Güneş, Erdi
This study involves detailed numerical and experimental investigations to assess the current structural condition of the Bamsı Beyrek steel observation terrace in Bayburt, Türkiye. The numerical dynamic characteristics of the structure were obtained by free vibration analysis conducted on the preliminary finite element model, while the experimental ones were determined through ambient vibration testing. The ultimate finite element models representing the actual state of the structure were developed through the model updating process based on the principle of minimizing the differences between numerical and experimental dynamic characteristics via the Teaching-Learning Based Optimization Algorithm. Load types and their characteristic values, potentially impacting the observation terrace during its service life, were identified according to national and international code standards. The internal forces obtained from the analysis conducted on the updated model under the influence of these loads were combined using various load combinations. The structure was then statically and dynamically checked based on the most critical responses calculated from these combinations. Structural responses are evaluated based on distributions in PMM ratios on the structure, PMM ratios of all elements according to the combination that causes the most adverse values, and maximum displacements. Consequently, considering all the findings obtained from the assessments conducted on the finite element model, which reflects the current state of the observation terrace under various loads, it has been concluded that the structure is statically and dynamically reliable and does not require any repair or strengthening procedures.
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2026Scopus SJRQ1The Effect of Inquiry-based Science Learning Supported By Augmented Reality On Scientific Process Skills and Academic Achievement in Preschool
Arici, Faruk
Inquiry-based learning (IbL) is widely recognized as an effective pedagogical approach in early science education; however, young learners often struggle to engage with abstract concepts and sustain inquiry processes. Augmented reality (AR) has the potential to address these challenges by enhancing interaction, visualization, and engagement in learning environments. Although previous studies have demonstrated the positive effects of IbL and AR separately, empirical evidence examining the combined impact of AR-supported IbL on preschool students’ academic achievement and scientific process skills (SPS) remains limited, particularly in early childhood science education. This study aimed to investigate the effects of AR-supported IbL, IbL alone, and the current preschool science curriculum on children’s academic achievement and SPS. In addition, participants’ perspectives on learning experiences, skill development, and instructional activities were explored. A mixed-methods design was employed with three groups: AR-supported IbL, IbL-only, and a control group following the existing curriculum. Quantitative data were collected using achievement and SPS assessments, while qualitative data were collected through repeated teacher observations and in-depth interviews conducted throughout the intervention. Results indicated that AR-supported IbL led to significantly higher academic achievement and SPS than IbL alone or the current curriculum. While IbL was more effective than the curriculum-based approach, integrating AR further strengthened inquiry cycles and particularly enhanced measurement, communication, and prediction skills. Observational and interview data supported these findings by revealing increased curiosity, engagement, and active participation. The findings suggest that integrating AR within inquiry-based pedagogical frameworks can substantially improve the effectiveness of preschool science education. Implications are discussed for curriculum design, teacher professional development, and the development of developmentally appropriate AR-supported learning environments.
- MakaleAçık Erişim2026Scopus SJRQ2Analysis of thermal energy storage in batch processes using phase change materials
Kaya, Nur Efşan; Ceviz, Mehmet Akif; Afshari, Faraz; Mandev, Emre; Köksal, Hüseyin
Batch reactors are widely utilized in the chemical, pharmaceutical, and food industries due to their simplicity, ease of operation, and maintenance. However, efficient energy management remains a key challenge, especially for systems operating under intermittent conditions. While phase-change materials (PCMs) offer potential for improving energy efficiency by storing and reusing waste heat, integrating heat storage within reactors can compromise their volume and design. This study introduces a novel approach by designing and experimentally testing a PCM heat battery positioned outside the reactor to reduce energy consumption cost in batch processes. By focusing on peak load shifting, the PCM heat battery stores thermal energy during off-peak periods, reducing operational costs and enhancing energy efficiency. The results indicate that energy operating costs can be significantly reduced with a PCM heat battery. Specifically, utilizing the PCM battery under a three-time tariff allows for the efficient use of energy stored at night, reducing the energy cost per batch process by approximately 8%, from 1.72 TL ($0.041) to 1.59 TL ($0.037) for facilities starting operations at 08:00. Furthermore, the findings suggest potential applications in systems like solar energy and highlight the benefits of peak load shifting, offering a sustainable and cost-effective solution for energy management in batch processing.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2026Scopus SJRQ1The effect of existing damage on the seismic performance of a historical masonry structure: a site-specific assessment
Tayfur, Bilal; Tunca, Osman; Artar, Musa; Çarbaş, Serdar
This study comprehensively evaluates the structural integrity and seismic performance of a historic masonry mosque, exhibiting significant settlement cracks, through an integrated approach combining field measurements and advanced numerical analyses. The Operational Modal Analysis (OMA) conducted to determine the dynamic characteristics of the structure. Field measurements revealed that the environmental vibrations originating from a nearby tram line causes significant amplitude incrase in one of the main columns. The dynamic characteristics of the structure obtained from field experiments are used to calibrate the numerical model via the Particle Swarm Optimization Algorithm. The calibrated numerical model, taking into account the existing cracks in the structure using contact elements, was subjected to nonlinear analysis in the time domain under 11 site-specific ground motion records selected in accordance with the procedures of the Turkish Building Seismic Code. This analysis examined the seismic performance and damage mechanisms of the structure. The findings revealed that while existing settlement cracks contribute to seismic energy dissipation through frictional sliding and gap opening mechanisms, they may also serve as potential failure initiation points under strong ground motions. This study’s integrated approach, combining dual-purpose OMA application and explicit crack modeling with contact elements, constitutes a novel methodological framework for the realistic seismic assessment of historic masonry structures with pre-existing damage.
AtıfScopus1WoS1OpenAlex2İncele - MakaleAçık Erişim2026Scopus SJRQ2Synthesis and pharmacokinetic profiling of a novel pyrimidine imidazole based thiosemicarbazone derivative for BRAF inhibition in lung cancer therapy
Ekincioğlu, Yavuz; Kızıl, Hamit Emre; Güllü, Eda; Özkan, Elvan Hasanoğlu; Nartop, Dilek
This study presents the design, synthesis, and comprehensive evaluation of a novel thiosemicarbazone derivative containing a pyrimidine-imidazole (C11H11N8SCl) as a potential BRAF inhibitor for the treatment of non-small cell lung cancer. The compound was synthesized by a condensation reaction and characterized by elemental analysis, molar conductivity, SEM-EDS, FT-IR, 1H, and 13C-NMR spectral techniques. DFT calculations at the B3LYP/6-311 + + G(d, p) level revealed a HOMO-LUMO gap of 2.8 eV, indicating appropriate molecular stability and reactivity. Molecular docking studies with BRAF (PDB ID: 1UWH) demonstrated favorable binding affinity (-6.85 kcal/mol) with key interactions at ILE512, HIS509, HIS584, GLN529, GLU585, LYS590, VAL510, and LEU587 residues. In vitro cytotoxicity assays revealed that the compound possesses anticancer potential against H-460 cells, with a significant inhibitory effect observed at a concentration of 200 µg/mL. Combined with its favorable binding affinity toward BRAF kinase, these results suggest that the pyrimidine-imidazole thiosemicarbazone may serve as a potential lead scaffold for further development in targeted lung cancer therapy.ADME profiling confirmed the compound’s compliance with Lipinski’s rule of five parameters, supporting its potential as an orally active drug candidate. These findings suggest that our pyrimidine-imidazole thiosemicarbazone represents a promising scaffold for the development of targeted BRAF inhibitors for lung cancer therapy.
- MakaleYalnız künye2026Scopus SJRQ1Problem posing on vectors in space: preservice teachers’ perspectives
Ergin, Ayda Nur; Öztürk, Mesut; Aydin, Tuba Ağirman
This study examines preservice elementary mathematics teachers’ problem-posing processes related to vectors in space. Adopting a qualitative case study design, the problem-posing process was analyzed by treating the phases of orientation, connection, generation, and reflection as analytic units, focusing on the cognitive, linguistic, and reasoning-based actions exhibited at each phase. The findings reveal that preservice teachers experience considerable difficulties in establishing meaningful connections between mathematical structures and real-life contexts, particularly when posing vector problems in three-dimensional environments. In addition, causal attribution processes became salient during the reflection phase, with participants frequently explaining their successes and difficulties by referring to their conceptual understanding, prior experiences, and perceived competence. The results offer implications for the design of theory-based learning environments that support problem-posing processes in mathematics teacher education, particularly for advanced mathematical topics.
- MakaleAçık Erişim2025Scopus SJRQ2Life cycle cost and carbon footprint analysis of CuO–Al2O3/water hybrid nanofluids in thermoelectric vaccine refrigerators
Cuce, Pinar Mert; Guclu, Tamer; Cuce, Erdem
This study investigates the application of a CuO–Al2O3/water hybrid nanofluid as a coolant in thermoelectric vaccine refrigerators, aiming to enhance heat dissipation from the Peltier module’s hot side. A 35-L cooling cabinet was utilised, and experimental comparisons were made using water and a 2% CuO–Al2O3/water hybrid nanofluid. Results show that the vaccine cabinet reaches the target temperature of 4 °C in 990 s with nanofluid, compared to 1200 s with water. The system’s energy consumption was reduced by 18.3%, and carbon emissions decreased by 12.3% over a 15-year lifespan, highlighting its environmental benefits. Despite similar coefficients of performance (COP), the nanofluid system demonstrates enhanced efficiency, shorter cooling times, and long-term sustainability advantages. These findings support the adoption of hybrid nanofluids in thermoelectric cooling applications for energy-efficient and environmentally friendly refrigeration systems.
AtıfScopus6WoS6OpenAlex8İncele - MakaleAçık Erişim2025Scopus SJRQ1An Examination of Factors Affecting Pre-service Science Teachers' Perceived Satisfaction Levels in Distance Education
Arici, Faruk; Salar, Rıza; Yilmaz, Rabia Meryem
With the advancement of technology, traditional classroom environments have been increasingly replaced by technology-driven learning settings. This transition has been further accelerated by global crises such as wars, health emergencies, and economic instability, pushing education beyond conventional boundaries. Among these settings, e-learning has significantly enhanced the accessibility and availability of education. This study aimed to examine the relationships between perceived satisfaction, learning outcomes, course structure, course content, instructor role, instructor feedback, and technology quality in e-learning. It also investigated the factors influencing university students' perceived satisfaction in both asynchronous and synchronous e-learning settings. The study involved 247 university students (47 males and 200 females) who participated in a one-year distance education program in science education. After attending synchronous and asynchronous courses for 14 weeks, data was collected. The findings revealed that students did not perceive distance education as more effective than face-to-face instruction. However, with an explained variance of 77%, the proposed model demonstrated that learning outcomes, course structure, course content, instructor role, instructor feedback, and technology quality significantly influenced perceived satisfaction. Among these, learning outcomes, course content, and technology quality had a direct impact. These findings highlight the need for educational institutions to enhance the quality of course content, technology infrastructure, and learning outcomes in e-learning environments to improve student satisfaction and engagement.
AtıfScopus2WoS1OpenAlex2İncele - MakaleYalnız künye2024Scopus SJRQ1Middle School Students’ Problem Solving Performance: Identifying the Factors that Influence It
Öztürk, Mesut; Sarikaya, İsmail; Ada Yıldız, Kübra
This research was carried out to examine the serial mediation role of mathematics self-efficacy and metacognition for problem-solving in the effect of reading comprehension on problem-solving. The relational research model, one of the quantitative research designs, was used in the study. A total of 699 middle school students studying in official public schools in Turkey participated in the study. SPSS and PROCESS macros were used in the analysis of the data of the study. The study revealed that reading comprehension, mathematics self-efficacy, and metacognition were related to problem-solving. The result of the study showed that mathematics self-efficacy and metacognition significantly mediate the relationship between reading comprehension and problem-solving.
AtıfScopus10WoS7OpenAlex19İncele - MakaleAçık Erişim2024Scopus SJRQ2Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells
Çınar, İrfan; Gıdık, Betül; Dirican, Ebubekir
Background: This study aimed to investigate the cytotoxic, apoptotic, invasion, metastasis, and heat shock proteins (HSPs) effects of N. sativa oil on breast and gastric cancer cells. Methods: We assessed the cytotoxic and apoptotic effects of various concentrations of N. sativa oil (10-50-100-200 µg/mL) on MCF7 breast cancer and AGS, an adenocarcinoma of the gastric cell line, at 24, 48 and 72 h using the MTT test. Additionally, the expression of the Caspase-3, BCL2/Bax, MMP2-9 and HSP60-70 gene was examined using RT-PCR in cell lines treating with N. sativa. Results: The MTT experiments demonstrate that N. sativa has a time and dose-dependent inhibitory effect on the proliferation of MCF7 and AGS cancer cells. The vitality rates of MCF7 and AGS cells treated with N. sativa were 77.04–67.50% at 24 h, 65.28–39.14% at 48 h, and 48.95–32.31% at 72 h. The doses of 100 and 200 µg/mL were shown to be the most effective on both cancer cells. RT-PCR analysis revealed that N. sativa oil extract increased caspase-3 levels in both cell lines at higher concentrations and suppressed BCL2/Bax levels. Exposure of MCF7 and AGS cell lines to N. sativa caused a significant decrease in the expression of MMP2-9 and HSP60-70 genes over time, particularly at a dosage of 200 µg/mL compared to the control group (p < 0.05). Conclusions: Our findings indicate that N. sativa oil has a dose-dependent effect on cytotoxicity and the expression of apoptotic, heat shock proteins, and matrix metalloproteinases genes in breast and gastric cancer.
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İncele - MakaleYalnız künye2024Scopus SJRQ1The Role of Picturebooks in Supporting the Mathematical Knowledge of Preschool Teacher Candidates
Güven Akdeniz, Dilşad
Is children’s literature only beneficial to children? Or do the benefits of children’s literature also extend to the knowledge and mathematical skills of the teachers who employ it and reflect on it? This study seeks to investigate the role of picturebooks on the mathematical knowledge of preschool teacher candidates. For this purpose, in-depth examinations of how picturebooks can be used in teaching preschool mathematics and children’s literature. As well as the changes in the content knowledge of the teacher candidates, were done by conducting focus group interviews with teacher candidates. This is a qualitative case study consisting of focus group discussions in which high-level knowledge sharing and production can be achieved through interaction and associations. In the research, 11 picturebooks were discussed, and 8 teacher candidates participated in 6 focus group interviews lasting a total of 338 min throughout a 7 week period. The study’s findings have demonstrated that through children’s literature, teacher candidates’ misconceptions about measuring length can be revealed and eliminated without the need for another source, with discussions based on consciously and systematically selected picturebooks. Thus, it can be said that picturebooks act as a catalyst for the studies that aim to enhance the mathematical content knowledge of teacher candidates. The study has also observed that picturebooks can comprehensively address the fundamental concepts of length measurement.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ1Assessment of Different Methods for Estimation of Missing Rainfall Data
Hırca, Tuğçe; Eryılmaz Türkkan, Gökçen
Missing data is a common problem encountered in various fields, including clinical research, environmental sciences and hydrology. In order to obtain reliable results from the analysis, the data inventory must be completed. This paper presents a methodology for addressing the missing data problem by examining the missing data structure and missing data techniques. Simulated datasets were created by considering the number of missing data, missing data pattern and missing data mechanism of real datasets containing missing values, which are often overlooked in hydrology. Considering the missing data pattern, the most commonly used methods for missing data analysis in hydrology and other fields were applied to the created simulated datasets. Simple imputation techniques and expectation maximization (EM) were implemented in SPSS software and machine learning techniques such as k-nearest neighbor (kNN), together with the hot-deck were implemented in the Python programming language. In the performance evaluation based on error metrics, it is concluded that the EM method is the most suitable completion method. Homogeneity analyses were performed in the Mathematica programming language to identify possible changes and inconsistencies in the completed rainfall dataset. Homogeneity analyses revealed that most of the completed rainfall datasets are homogeneous at class 1 level, consistent and reliable and do not show systematic changes in time.
AtıfScopus22WoS23OpenAlex27İncele - MakaleAçık Erişim2023Scopus SJRQ2Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
Kızıl, Hamit Emre; Caglayan, Cuneyt; Darendelioğlu, Ekrem; Ayna, Adnan; Gür, Cihan; Kandemir, Fatih Mehmet; Küçükler, Sefa
Background: Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side effects of long-term MTX use. The present study unveils new confirmations as regards the remedial effects of morin on MTX-induced hepatocellular injury through regulation of oxidative stress, apoptosis and MAPK signaling. Methods and results: Rats were subjected to oral treatment of morin (50 and 100 mg/kg body weight) for 10 days. Hepatotoxicity was induced by single intraperitoneal injection of MTX (20 mg/kg body weight) on the 5th day. MTX related hepatic injury was associated with increased MDA while decreased GSH levels, the activities of endogen antioxidants (glutathione peroxidase, superoxide dismutase and catalase) and mRNA levels of HO-1 and Nrf2 in the hepatic tissue. MTX treatment also resulted in apoptosis in the liver tissue via increasing mRNA transcript levels of Bax, caspase-3, Apaf-1 and downregulation of Bcl-2. Conversely, treatment with morin at different doses (50 and 100 mg/kg) considerably mitigated MTX-induced oxidative stress and apoptosis in the liver tissue. Morin also mitigated MTX-induced increases of ALT, ALP and AST levels, downregulated mRNA expressions of matrix metalloproteinases (MMP-2 and MMP-9), MAPK14 and MAPK15, JNK, Akt2 and FOXO1 genes. Conclusion: According to the findings of this study, morin may be a potential way to shield the liver tissue from the oxidative damage and apoptosis.
AtıfScopus74WoS71OpenAlex82İncele - MakaleAçık Erişim2023Scopus SJRQ1Evaluation of Optimal Energy Productıon Usıng Deterministic, Probabilistic and Risky Cases In a Multi-Reservoir System
Bacaksız, Efsun; Opan, Mücahit; Kara Dilek, Zuhal Elif; Karadeniz, Murat
In a multi-reservoir system, the stochastic nature of basin data resulting from rainfall introduces risk into water management operations. Effective management that accounts for these risks can obtain maximum benefits from the system. This study presents a description of a multi-reservoir water resources system with hydroelectric power plants, utilizing the energy optimization model developed by OPAN in 2007. The model was applied to reservoirs located successively on the Lower Kızılırmak River in the Kızılırmak Basin, with the objective function being the maximization of firm power by using drought period inflows and total energy by using monthly average inflows. The study considered three scenarios: deterministic, probabilistic, and risky (critical cases), with probabilities of inflows from the basin being determined for the latter. Monthly inflows with determined probabilities were used to obtain data for the risky case. Optimum operating levels were determined based on this data to maximize firm power and total energy. According to the operating levels, the reservoir with the largest useful volume manages the operation. The values obtained from the optimization were then used in multivariate regression analysis using the Statistical Package for Social Scientists (SPSS), a statistical analysis program. The analysis explored the effects of monthly operating levels in the reservoirs, the amount of inflow released from the spillway, the amount of inflow released for energy production, the monthly average inflow to the reservoirs, and firm power values on energy production.
AtıfScopus7WoS6OpenAlex7İncele - MakaleAçık Erişim2022Scopus SJRQ2Investigation of the biological treatability of pistachio processing industry wastewaters in a batch-operated aerobic bioreactor
Tırınk, Sevtap; Nuhoğlu, Alper; Kul, Sinan
This study encompasses investigation of treatment of pistachio processing industry wastewaters in a batch reactor under aerobic conditions, calculation of kinetic parameters and comparison of different inhibition models. The mixed microorganism culture used in the study was adapted to pistachio processing industry wastewaters for nearly one month and then concentrations from 50 to 1000 mg L−1 of pistachio processing industry wastewaters were added to the medium and treatment was investigated in batch experiments. The Andrews, Han-Levenspiel, Luong and Aiba biokinetic equations were chosen for the correlations between the concentration of pistachio processing industry wastewaters and specific growth rates, and the kinetic parameters in these biokinetic equations were calculated. The maximum specific growh rate, semi-saturated constant and inhibition constant parameters, included in the Aiba biokinetic equation providing best fit among the other equations, had values calculated as 0.25 h−1, 19 mg L−1, and 516 mg L−1, respectively. The substrate value reaches maximum value and the specific growth rate at this concentration were calculated as 101.379 mg L−1 and 0.1827 h−1, respectively. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus4WoS4OpenAlex5İncele - MakaleAçık Erişim2022Scopus SJRQ2Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1α in SARS-Cov-2 infected patients
Karabulut Uzunçakmak, Sevgi; Naldan, Muhammet Emin; Dirican, Ebubekir; Kerget, Ferhan; Halıcı, Zekai
Background: Coronavirus-19 is still considered a pandemic that influences the world. Other molecular alterations should be clearer besides the increasing cytokine storm and pro-inflammatory molecules. Hypoxic conditions that induce HIF-1α lead to stimulate gene expression of STC-2 that targets PAPP-A expression. This study aimed to determine gene expression levels of PAPP-A, STC-2, and HIF-1α in COVID-19 infection. We also aimed to reveal the relationship of these genes with laboratory and clinical data of COVID-19 patients. Materials and Results: We extracted RNA from peripheral blood samples of COVID-19(+) and COVID-19(−) individuals. The real-time PCR method was used to measure mRNA expression of PAPP-A, STC-2, and HIF-1α. Gene expression analysis was evaluated by the 2−ΔΔCt method. PAPP-A, STC-2, and HIF-1α mRNA expressions of severe patients were higher than healthy individuals (p = 0.0451, p = 0.4466, p < 0.0001, respectively). Correlation analysis of gene expression patterns of severe patients demonstrated a positive correlation between PAPP-A and STC-2 (p < 0.0001, r = 0.8638). Conclusion: This is the first study that investigates the relation of PAPP-A, STC-2, and HIF-1α gene expression in patients with COVID-19 infection. Besides the routine laboratory findings, PAPP-A, STC-2, and HIF-1α mRNA expressions may be considered to patients’ prognosis as a sign of increased cytokines and pro-inflammatory molecules.
AtıfScopus6WoS6OpenAlex8İncele - MakaleAçık Erişim2021Scopus SJRQ1The investigation of flood risk perception as a quantitative analysis from socio-demographic perspective
Eryılmaz Türkkan, Gökçen; Hırca, Tuğçe
The priority of flood management planning is physical victimization and focuses on taking structural measures. Although this approach is an accurate approach, more information is needed in implementing efficient precautionary and planning decisions. It is an indisputable fact that the existence of nothing that is not sustainable in nature cannot continue. Hence, it is necessary to implement a planning decision suitable for the structure of the population living in the region so that the continuity of the policies to be carried out against natural hazards of hydrometeorological origin such as a flood is ensured. How the socio-demographic structures affect the flood risk perception of 245 people living in the city center of Bayburt is examined in this study. It is the first research conducted for the province of Bayburt for this perspective. The participants were asked to fill a questionnaire containing 24 items and consisting of 2 sections. T test and one-way ANOVA (one-way analysis of variance) statistical methods were used to ascertain the difference between the responses of the participants to the questionnaire, based on their demographic structure. As the result of the study, significant differences were observed between the expressions depicting flood risk perception and the participant's age, income levels and educational background. In addition, it has been noted that there is a positive relationship between education and income levels and flood risk perception.
AtıfScopus30WoS23OpenAlex39İncele