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- MakaleAçık Erişim2021Okul öncesi eğitim etkinlik kitabının yenilenmiş bloom taksonomisi’ne göre incelenmesi
Yilmaz, Arif; Akbaba, Fikrinaz Damla; Halipinar, Fatma Merve; Oral, Selin; Ulusoy Ünlü, Ayşenur
Eğitim-öğretim dönemi boyunca sınıf içinde uygulanabilecek etkinlikler okul öncesi eğitim programının temelini oluşturmaktadır. İyi ve etkili bir şekilde planlanmış etkinlikler hem çocukların gelişimine hem de öğretmenlerin mesleki deneyimlerine katkı sağlaması açısından çok önemlidir. Bu doğrultuda, Millî Eğitim Bakanlığı Temel Eğitim Genel Müdürlüğü tarafından öğretmenlere rehber olması için “Okul Öncesi Eğitim Etkinlik Kitabı” hazırlanmıştır. Bu araştırmada, etkinlik kitabında yer alan etkinliklerin kazanım ve göstergelerinin Yenilenmiş Bloom Taksonomisi’ne göre hangi basamakta yer aldığını ortaya koymak amaçlanmıştır. Araştırma, nitel araştırma yöntemlerinden biri olan durum çalışması olarak gerçekleştirilmiş ve doküman incelemesi tekniği kullanılmıştır. Çalışma çerçevesinde kitapta yer alan 341 etkinliğin 27’si basım hataları sebebiyle değerlendirmeye alınmamış, geriye kalan 314 etkinliğin içerdiği 1234 kazanım Yenilenmiş Bloom Taksonomi’sine göre bilişsel süreçler bakımından sınıflandırılmıştır. Kazanımların sınıflandırılmasında “Kazanım Değerlendirme Formu” ve “Etkinlik Değerlendirme Formu” kullanılmıştır. Sonuçlara göre, kazanımların büyük çoğunluğunun bilişsel gelişim alanına yönelik olduğu, kazanımların birçoğunun 3. basamak olan uygulama basamağında yer aldığı ve analiz, değerlendirme, yaratıcılık gibi üst basamaklarda yer alan kazanım sayısının daha az olduğu, kazanımların yoğunluğun ilk üç basamakta yer aldığı görülmüştür. Araştırmadan elde edilen bulgular neticesinde, kitaptaki kazanım ve göstergelerin üst düzey becerileri destekleyecek şekilde kullanılması ve gelişim alanlarının etkinlik türlerinde dengeli dağılması gerektiği ortaya çıkmıştır.
AtıfOpenAlex8TR Dizin8
İncele - MakaleAçık Erişim2021Determination of the artificial aging performance of the apricot wood applied with UV system parquet varnish used indoors
Ayata, Ümit; Gürleyen, Levent; Çakıcıer, Nevzat
Abundantly grown for apricot tree fruit. Apricot wood is used for different purposes. The aim of this study is to determine the performance of the ultraviolet (UV) system parquet varnished layers against artificial aging applied to apricot (Prunus armeniaca L.) wood. For this purpose, UV system parquet varnish was applied on apricot wood surfaces in 3 and 5 layers in accordance with industrial applications. The materials obtained were exposed for 252 and 504 h in an accelerated aging device with UVA-340 lamp. After aging, lightness (L*), red (a*) color tone, yellow (b*) color tone, perpendicular (⊥) and parallel (//) glossiness values to the fibers at 20o, 60o and 85o, adhesion resistance and pendulum hardness (könig method) tests were determined. According to the results of the research, variance analysis was obtained significantly for all tests. After aging, for both varnish applications, all glossiness values, yellow color tone and lightness values decreased, while red color tone values increased. While the hardness decreased in the 3-layer application, the adhesion resistance was increased, and the 5-layer application gave an opposite result.
AtıfOpenAlex19TR Dizin8İncele - MakaleAçık Erişim2021Sibirya’da iç ve dış mekânlarda kullanılan Sibirya çamı odununun yüzey pürüzlülüğü parametreleri ve shore D sertlik değeri üzerine ısıl işlemin etkisi
Ayata, Ümit
Sibirya çamının Sibirya’da yetiştiği ve odununun hafif, yumuşak, iyi işlenebilen özelliği, düzgünlüğü ve güzel doku yapısı ile kalem yapımında, inşaat alanlarında, ev yapımında, müzik aletleri yapımında, mobilya alanında ve çeşitli el sanatlarının yapımında kullanıldığı bilinmektedir. Bu araştırmada, 212oC’de 2 saat sürede ısıl işlem (ThermoWood) uygulanmış ve uygulanmamış Sibirya çamı (Pinus sibirica) odununda hazırlanmış olan örnekler üzerinde farklı zımparalar (80, 100, 120, 150, 180 ve 220 numaralı) uygulandıktan sonra yüzey pürüzlülüğüne ait parametreleri (Ra, Rz ve Rq) ve shore D sertlik değerleri araştırılmıştır. Araştırma sonuçlarına göre, pürüzlülük parametreleri ve shore D sertlik değerleri ısıl işlem ile azalmıştır. Isıl işlem sonrası shore D sertlik değerinde %20.43’lük, Ra parametrelerinde 80 numarada %22.16’lık, 100 numarada %26.25’lik, 120 numarada %36.42’lik, 150 numarada %35.71’lik, 180 numarada %36.38’lik ve 220 numarada %50.88’lik oranlarda azalmalar meydana gelmiştir. Buna ek olarak, zımpara numarasının artması ile pürüzlülük değerlerinin de azaldığı, yüzey kalitesinde artış olduğu ve iyi sonuçlara ulaşıldığı belirlenmiştir.
AtıfOpenAlex2TR Dizin2İncele - MakaleAçık Erişim2022CYB mtDNA mutations and expression status of genes in the PI3K/AKT/mTOR signaling pathway in patients with schizophrenia
Dirican, Ebubekir; Uzunçakmak, Sevgi Karabulut; Özcan, Halil
Purpose: This study aimed to screen for cytochrome b (CYB) mitochondrial DNA (mtDNA) mutations and analyze the mRNA expressions of genes in the PI3K/AKT/mTOR signaling pathway in patients with schizophrenia. Materials and Methods: In this study, whole blood was obtained from 44 schizophrenic patients and 41 healthy individuals for DNA (patients) and RNA (patients and control) isolation. Samples for CYB mtDNA mutations were amplified by PCR and identified by Sanger DNA sequencing. RT-PCR and 2- increment increment Ct method was used for mRNA expression of PIK3CA, AKT1, and mTOR genes. Results: In schizophrenia patients, m.15326 A > G (43/44), m.15452 C > A (5/44), m.15078 A > G (3/44), m.14872 C > T (3/44) and m.14798 T > C (3/44) was the most common CYB mtDNA mutations. In silico analysis showed that some of the mutations were associated with the harmful, disease-causing or benign character. The mRNA expression of the PIK3CA, AKT1, and mTOR genes in schizophrenia patients was significantly higher than in healthy individuals. There was a significant moderate positive correlation between the PIK3CA and AKT1 genes. In addition, by ROC analysis, PIK3CA, AKT1 and mTOR genes were found to have good diagnostic power in the patient group. ROC analyzes showed that PIK3CA in particular has significant diagnostic value for schizophrenia patients with 80% sensitivity and 63.4% specificity. Conclusion: Both of CYB mtDNA mutations frequency and PIK3CA, AKT1 and mTOR mRNA expression were higher in schizophrenic patients compared to healthy individuals. We believe that studying these mechanisms in
AtıfWoS1OpenAlex1TR Dizin1
İncele - MakaleAçık Erişim2022Impact of gossypin on gene expression of HSP60 and HSP70 in different cancer cell lines
Dirican, Ebubekir; Çinar, Trfan
Purpose: The aim of this study is to evaluate the impact of gossypin on the expression level of heat shock proteins (HSPs) genes in different cancer cells. Materials and Methods: Cells were grown under standard culture conditions. Cancer cells were treated with different concentrations (5-100 mu g/ml) of gossypin and cisplatin (50 mu M) as positive control. Cell viability and effective dose range (5-100 mu g/ml) of gossypin were determined by MTT at 24, 48 and 72 hours. After RNA isolation and cDNA synthesis, HSP60 and HSP70 gene expression levels were analyzed using RT-PCR. For gene expression analysis, the 2-(Delta Delta ct) method was used. Results: According to the Mil results, 25-50-100 mu g/ml of gossypin doses were found effective on HSP60 and HSP70 gene expression levels in the cancer cell lines. Gossypin affected with dose-dependently the expression of HSP60 and HSP70 in the three cell lines. In the three cell lines, 50 mu g/ml and 100 mu g/ml of gossypin doses significantly reduced the expression of HSP60 and HSP70 compared to control group. Conclusion: Our results strongly supported the anticarcinogenic effect of gossypin at various doses in different cell lines. However, we believe that further in vivo research and human studies are needed. Our findings suggest that gossypin could be suitable candidate agent for further investigation to develop new strategies for the prevention and/or treatment of different cancer types.
AtıfWoS1OpenAlex2İncele - MakaleYalnız künye2010Scopus SJRQ3ANALYSIS OF HEAT PUMPS WITH ZEOTROPIC REFRIGERANT MIXTURES BY TAGUCHI METHOD
Comakli, Omer; Comakli, Kemal; Ozdemir, Nesrin; Yilmaz, Mehmet
The goal of this work is to determine the optimum set of parameters by using the Taguchi method in vapour compression heat pump systems. The experimental apparatus consist of an air-to-liquid vapor compression heat pump, a water cooled condenser, a forced air evaporator, an electrical air and water heaters, and various measuring elements and other auxiliary equipments. Refrigerants R22, R407C, and five of their binary mixtures which contain about 0%, 25%, 50%, 75%, and 100% mass fractions of R407C were tested. To determine the effect of the chosen parameters on the system and optimum working conditions, an experimental design method suggested by Genichi Taguchi was used. The most effective parameters are found to be the condenser water mass flow rate for the coefficient of performance and to be condenser water inlet temperature for the exergetic efficiency.
AtıfWoS6İncele - MakaleAçık Erişim2021Effect of Liquid and Solid Vermicompost Applications on Growth and Yield of Sunflower (Helianthus annuus L.)
Gül, Volkan; Coban, Furkan; Öztürk, Erdogan
Vermicompost, which is not harmfull to the environment, and is increasing in agricultural production in terms of both gaining to the soil and benefiting the waste. This research was carried out in 2019 in Bayburt ecological conditions in order to determine the impacts of different doses of solid (250, 500 and 750 kg da(-1)) and liquid (0, 250, 500 and 750 ml da(-1)) vermicompost fertilizers on the flowering and maturation period (days), stem diameter (cm), table diameter (cm), plant height (cm), thousand weight (g) seed yield (kg da(-1)), seed internal rate (%) oil ratio (%) and oil yield (kg da(-1)) of sunflower (Helianthus annuus). In the experiment, it was determined that all parameters were statistically significant compared to p<0.01. The highest seed (218.7 kg da(-1)) and oil yield (75.9 kg da(-1)), which are the most important parameters in oil sunflower, were obtained in 750 kg da(-1) solid and 750 ml da(-1) Liquid vermicompost application (K3S3). As a result, the use of solid and liquid vermicompost application in oil sunflower together will be beneficial in obtaining the highest healthy, high quality seed and oil yield.
AtıfWoS4OpenAlex4İncele - MakaleYalnız künye2022Scopus SJRQ3Comparative Analysis of Migrant Integration Policies of Turkiye and Selected Countries
Ustabulut, Mete Yusuf; Boylu, Emrah; Basar, Umut
Turkiye's migrant integration policy, which is one of the most migration-receiving countries in the Middle East owing to regional conflicts during the 2000s, is assessed alongside that of other receiving nations in the Migrant Integration Policy Index (MIPEX). These index ranks nations in eight key categories: labor market mobility, family reunion, education, health, political participation, permanent residence, access to nationality, and anti-discrimination. This study examines Turkiye's change in migration policy ratings by comparing the index 2015 and 2020 with six European countries (Germany, Belgium, France, Norway, Finland, Sweden). It is found that there was a significant disparity in index scores between Turkiye and these European countries in the 2015 MIPEX report; however, this difference has narrowed in the 2020 report. Turkiye's migrant integration policy rankings have improved substantially (+17), according to the 2020 report. As a result, Turkiye's policy indicator has increased from slightly unfavourable to halfway favourable . Although this score and increase are not at the desired level, they may indicate comprehensive improvements in Turkiye's integration policies in the following report.
- BildiriAçık Erişim2015Preservice elementary mathematics teachers' written views on the concept of instructional activity
Öztürk, Ferhat; Isik, Ahmet; Öztürk, Bilge
The purpose of this study is to reveal the views of preservice elementary mathematics teachers on the concept of instructional activity. Of qualitative research patterns, the case study method has been employed in this study. The research group of the study is made up of a total of 12 preservice elementary mathematics teachers studying the fourth grade at the department of elementary mathematics teaching in a state university located in the Eastern Anatolian Region of Turkey during the fall semester of the 2013-2014 academic year. In the study, to get the opinions of preservice teachers on the concept of instructional activity, a written feedback form containing three open-ended questions was applied to the preservice teachers. Then, content analysis was conducted on the data obtained from the written feedback form. The study has revealed that preservice teachers have different opinions on the concept of instructional activity. (C) 2015 The Authors. Published by Elsevier Ltd.
AtıfOpenAlex1İncele - BildiriYalnız künye2016Scopus SJRQ1Functional properties of lactic acid bacteria (LAB) playing crucial roles on sourdough biotechnology
Dertli, Enes; Yilmaz, Mustafa Tahsin
AtıfWoS1OpenAlex2İncele - MakaleYalnız künye2010Effect of Alternative Expanded Perlite Using on Properties of Raw Perlite Aggregated Light-Weight Concrete
Gökçe, H. Suleyman; Simsek, Osman; Durmus, Gokhan; Demir, Ilhami
Perlite is a natural building materials contribute to global warming positive thanks to its isolation and lightness characteristics as concrete aggregate with usage of in construction sector. In research results, about %74 of world perlite reserves was determined to be in Turkey. It is thought that energy of fairly hard obtained will provide more efficient usage thanks to efficient usage of the natural reserves. Such approaches will provide to reduce of environment pollution in the usage of energy. In this study, with different characteristic usability of expanded perlite aggregate was researched in raw perlite aggregated light weight concrete. 7 different mixtures were prepared in volume at 10% ratio by using 3 different expanded perlite aggregate instead of raw perlite aggregate. With prepared light weight concrete mixtures 100x100x100 mm sized cube samples were produced. 28 days compressive strength, unit volume weight and water absorption ratio of these sample were researched. As a result, with suitable characteristic usage of expanded perlite aggregate was understood to be effective on the mechanical and physical properties of perlite aggregated light weight concrete.
AtıfWoS3İncele - MakaleAçık Erişim2024Scopus SJRQ2Numerical simulation of the flow passing through the side weir-gate
Kartal, Veysi; Emiroglu, M. Emin
A combination of a weir and a gate is called the combined weir-gate. The hydraulic behaviour of the combined side weir-gate was numerically and experimentally investigated in the study. The findings were evaluated to investigate the impact of combined flow and weir-gate geometry characteristics on the discharge capacity of the side weir-gate. Thirty-three numerical simulations were conducted. The numerical simulations were performed by applying the Volume of Fluid (VOF) method to the Reynolds-averaged Navier-Stokes (RANS) equations using Flow-3D using k-epsilon turbulence model. The model was validated against experimental data previously obtained by the authors, and eighty-eight experiments were conducted to analyze using different models. The findings show that the models with rectangular weir and gate cross-sections have higher discharge capacity than those with triangular and semicircular gates, and the models with semicircular gates have higher discharge capacity than those with triangular gates. The Absolute Percentage Error (APE), Root Mean Square Error (RMSE), Scatter Index (SI) and Coefficient of Determination (R2) of the numerical and experimental results are 4.11 %, 0.30 % and 0.10 %, 0.99, respectively. The results show that experimental and numerical findings and discharge capacity are consistent.
AtıfWoS8OpenAlex11İncele - BildiriAçık Erişim2016Scopus SJRQ1Antagonistic activities of lactic acid bacteria isolated from Pastirma
Cinar, Kubra; Kaya, Mukerrem; Kaban, Guzin
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2023Prioritising and selecting the railway routes planned in the Eastern Black Sea Region with the AHP and TOPSIS methods
Boz, Ediz; Türk, Ersin; Togan, Vedat
The construction of the railway, which is needed for the development of the Eastern Black Sea Region, is an issue that has been discussed and unresolved for about 110 years. The geomorphological structure of the region and the developments in the highway played a role in the delay of the railway construction. However, the developing technology in the railway, Turkey's being a part of the Iron Silk Road Project, and the agreements made with international connections have brought the railway construction to the region again. In the Environmental Plan (EP) approved and in force by the Ministry of Environment, Urbanization and Climate Change, four railway routes are planned to integrate the Eastern Black Sea region with the national/international railway network. These routes are; Samsun-Sarp, Trabzon-Erzincan, Of -Erzurum and Tirebolu-Bayburt. However, some of these routes are alternatives to each other and are not feasible and rational since the implementation of all planned routes requires great costs. The aim of this study is to develop a method for prioritizing and selecting the railway routes planned in the EP. Within the scope of this purpose, by using Analytical Hierarchy Process (AHP) and TOPSIS techniques, which are multi-criteria decision making methods, the routes were listed according to 4 criteria and 10 sub-criteria determined with the help of literature and expert team. As a result of the study; In both techniques, the order was the same and it was determined that the Samsun-Sarp railway was the most priority railway route. Trabzon-Erzincan came second, Of-Erzurum came third and Tirebolu-Bayburt came fourth.
AtıfWoS3OpenAlex3TR Dizin2İncele - MakaleYalnız künye2020Scopus SJRQ1Butter production from ozone-treated cream: Effects on characteristics of physicochemical, microbiological, thermal and oxidative stability
Sert, Durmus; Mercan, Emin; Kara, Ummugulsum
The goal of this research was to investigate the effects of the ozone treatment (OT) to raw cream on the physicochemical, microbiological, thermal, and oxidative properties of butter. For this purpose, butter samples were produced from raw cream, which was ozone-treated for 5 (OT-5), 15 (OT-15), 30 (OT-30), and 60 (OT-60) min. The control sample was also produced from non-ozonated raw cream. OT increased firmness, consistency, and fat particle size values of cream. The firmness of butter was between 97 and 380 N. Average fat particle size of samples (D[3.2]) ranged from 22.1 to 30.2 mu m, in which OT decreased it. A monomodal fat particle size distribution was determined in all-butter samples. OT decreased b value (yellowness) of butter, and the lowest value was determined in OT-60. The induction time of butter changed from 1.04 (OT-60) - 32.9 h (control). Two melting peaks were determined in butter samples at 14.2-14.6 and 32.3-33 degrees C. Ozonation for 60 min caused 2.01 log reduction in Staphylococci. Above 15 min, OT completely inactivated Salmonella and yeast-mould. Coliform was not detected in OT-30 and OT-60. The results showed that OT resulted in higher microbiological quality in butter from raw cream.
AtıfWoS28OpenAlex30İncele - MakaleAçık Erişim2022Investigation of the effect of gossypin on MMP-2 and MMP- 9 genes in prostate cancer cells
Dirican, Ebubekir; Çinar, Irfan
Purpose: The aim of this study is to explore the effects of gossypin on matrix metalloproteinases -2 (MMP-2) and MMP-9 genes in prostate cancer cells. Materials and Methods: PC3 cells were grown in culture and treated with three different concentrations of gossypin (25-50-100 mu g/ml) and cisplatin (50 mu M) as a positive control. First, RNA isolation was performed. Then, cDNA synthesis was performed and RT-PCR was used to evaluate mRNA expression levels of MMP-2 and MMP-9 genes. Results: Gossypin decreased MMP-2 and MMP-9 mRNA expression in prostate cancer cells in a concentrationdependent manner. Three concentrations (25-50-100 mu g/ml) of gossypin in PC3 cells reduced the mRNA expression of the MMP-2 gene. While the fold change value of MMP-2 gene expression was 0.3482 +/- 0.040 in the 100 mu g/ml gossypin group, it was 1.007 +/- 0.1425 in the control group. In addition, 50 mu g/ml and 100 mu g/ml concentrations of gossypin decreased the mRNA expression of the MMP-9 gene. The expression level of the MMP-9 gene in prostate cancer cells was 0.4740 +/- 0.038 in the 100 mu g/ml gossypin administered group, while it was 1.009 +/- 0.1687 in the control group. There was a positive correlation between the expressions of the MMP-2 and MMP-9 genes. Conclusion: According to the results obtained, it is seen that gossypin reduces the expression of MMP-2 and MMP9 genes in prostate cancer cells and the effects of gossypin on other genetic and epigenetic mechanisms in cancer need to be investigated to reveal the anti-cancer.
AtıfWoS2OpenAlex2TR Dizin1İncele - EditoryalAçık Erişim2020Opinions and Thoughts of Undergraduate Students Receiving Sports Education on Ethical Behaviours in Sports
Sirinkan, Mete; Önal, Levent; Sirinkan, Cem
- MakaleAçık Erişim2022Exploring Problem Areas of Elderly Patients with Diabetes and the Support Provided by Their Family
Dastan, Buket; Hintistan, Sevilay
Objective: Diabetes increases problems in emotional areas particularly among the elderly patients by aggravating negative emotions such as loss, anxiety and fear and makes these patients need higher level of family support. This study aims at exploring problematic areas of the elderly diabetic patients and their family support levels. Methods: The data of this descriptive study were collected by the researcher by conducting a face to face interview with 218 elderly diabetic patients who presented to Endocrine Polyclinics of State Hospital between October 2015 and October 2016. To collect the data, Patient Information Form, Problem Areas in Diabetes Scale (PAID) and Hensarling's Diabetes Family Support Scale (HDFSS) were used. Results: Although problem areas among the patients were found to be fewer than expected; it was found that there were significant differences between problem areas and sex, diabetes time, treatment type, length of oral antidiabetic medicine use and insulin use, development of diabetes-related complication and hospitalization due to these complications in the recent year (p<0.05). Besides, the family support levels of the elderly patients were below the moderate level, and the number of individuals the patients live together with, the number of people receiving support due to diabetes and the number of people who received support from their spouses because of diabetes was a significant variable that affected HDFSS total score and the subscale scores (p<0.05). Conclusion: For a better diabetes management, sex and diabetes related variables should be taken into consideration while delivering health services and increasing family support levels can make positive contributions to the mood of the elderly patients.
AtıfWoS1OpenAlex1İncele - MakaleYayıncıda açık erişim2025Answer-based and reference-based BERT models for automatic scoring of Turkish short answers: The decisive role of task complexity
Kara, Abdulkadir; Kara, Zeynep Avinc; Yildirim, Serkan
In measurement and evaluation processes, natural language responses are often avoided due to time, workload, and reliability concerns. However, the increasing popularity of automatic short-answer grading studies for natural language responses means such answers can now be measured more quickly and reliably. This study aims to build models for predicting automatic short answer scores using the pre-trained BERT deep learning language model and to reveal their effectiveness. For this purpose, two different score prediction models were created using an answerbased approach that aligns student answers with expert judgements and a referencebased approach that matches student answers with reference answers. The dataset includes answers from 246 Physics department students responding to 4 physicsrelated questions. The performance of these models was evaluated on four physics questions representing varying levels of cognitive complexity, using Cohen's Kappa for statistical comparison of agreement with expert scores. Our findings reveal a clear interaction between model architecture and task complexity. The answer-based model was unequivocally superior for the most complex, multi-class task, effectively capturing diverse, nuanced responses. Conversely, the reference-based model demonstrated a statistically significant advantage for a well-defined, mediumcomplexity binary task. This study concludes that the optimal model for ASAG in Turkish is contingent on the cognitive demands of the assessment task, suggesting that a onesize-fits-all solution may not be the most effective approach. This provides a critical framework for practitioners, demonstrating not only that effective models are feasible for complex languages, but that their selection must be guided by task complexity.
AtıfWoS1OpenAlex2İncele - MakaleAçık Erişim2021Expression level of the angiotensin 2 (ACE2) gene in patients with COVID-19
Dirican, Ebubekir; Aydin, Ismail Erkan; Savrun, Seyda
Purpose: Coronavirus disease-19 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV2). The angiotensin converting enzyme 2 (ACE2) can play a vital role in regulating the pathological changes of various diseases, including COVID-19. The aim of this study was to analyze the expression of the ACE2 gene in Turkish COVID-19 patients. Materials and Methods: Eighty COVID-19 PCR test positive patients and 80 PCR test negative healthy volunteers were included in the study. RNA isolation was carried out from all samples. The RT-PCR device was used to analyze the expression of the ACE2 gene. Results: A significant difference was found in the age, Lactate dehydrogenase (LDH), ferritin and C-reactive protein (CRP) levels of the COVID-19 patients compared to the healthy volunteers. Based on the gene expression results, it was found that ACE2 gene expression was significantly higher in COVID-19 patients compared to healthy volunteers. In patients with COVID-19, a significant difference was found between the expression of the ACE2 gene and the levels of Blood urea nitrogen (BUN), Hemoglobin (HGB), Hematocrit (HCT) and CRP. Conclusion: ACE2 gene expression was high in the COVID-19 patients and showed differences based on clinical data. Thus, the expression of ACE2 can have paradoxical effects that support the pathogenicity of SARSCoV2 but, conversely, limit viral infection. The availability of ACE2 receptors may increase the susceptibility and / or disease course of COVID-19.
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