Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Kantar, Naciye Kutlu(6)
- Elbir, Tugba(2)
- Kamiloğlu, Aybike(2)
- Yılmaz, Merve Sılanur(2)
- Şakıyan, Özge(2)
- Alım, Bünyamin(1)
- Ates, Fatih(1)
- Barut, Burak(1)
- Bayram, Sinan(1)
- Baştürk, Fatma Nur(1)
- Cengiz, İbrahim(1)
- Ecem Bayram, Nesrin(1)
- Erdem, Gizem Melissa(1)
- Fandaklı, Seda(1)
- Gerçek, Yusuf Can(1)
- Guler, Cuneyt(1)
- Gül, Volkan(1)
- Güven, Onur(1)
- Isci, Asli(1)
- Kul, Sinan(1)
- Kurt, Mehmet Ali(1)
- Oruç, Şeref(1)
- Paloluoğlu, Cihan(1)
- Sancak, Kemal(1)
- Serencam, Hüseyın(1)
- Uzuner, Ugur(1)
- Uçurum, Metin(1)
- Yayli, Nurettin(1)
- Yildirim, Nazlican(1)
- Yucel, Tayyibe Beyza(1)
- Yıldırım, Ümit(1)
- Yılmaz, Bahadır(1)
- Yılmaz, Özlem(1)
- Çelik, Saffet(1)
- Öztürk, Elif(1)
- İşci, Aslı(1)
Yayınlar
- MakaleAçık Erişim2024Correlating Gas/Particle-Phase Concentration of Indicator Polychlorinated Biphenyls with Meteorological Factors in Bayburt, an Important University City of Turkey
Paloluoğlu, Cihan
This study was carried out in two seasons in Bayburt University Baberti Campus (BUBC) in Bayburt city, which is an important university city in Turkey. Gas and particle phase atmospheric concentrations of Urban atmospheric Indicator Polychlorinated Biphenyls (i-PCBs: PCB#28, 52, 101, 118, 138, 153, 180) were determined at first. Then, by using different methods, the interactions between i-PCB concentrations and meteorological factors were investigated. Gas and particle phases of atmospheric i-PCB samples were collected using a high-volume air sampler (HVAS) in BUBC . Following this stage, the samples were analyzed in a gas chromatography-mass spectrophotometer (GC-MS) by passing through appropriate extraction steps. According to the data obtained, the average gas phase ∑i-PCB concentration for the summer month was determined to be 11.314 pg/m3 during the sampling period while the average particle phase ∑i-PCB concentration was found to be 2.145 pg/m3. The average gas phase ∑i-PCB concentration was found to be 4.582 pg/m3 for the winter period while it was found to be 1.756 pg/m3 for the average particle phase ∑i-PCB concentration. In addition, the average total concentrations of i-PCBs were calculated to be 19.797 pg/m3. It was determined that meteorological factors especially temperature (from the Clausius–Clapeyron equation), wind velocity and direction, and rainfall have significant impacts on i-PCB concentration and its distribution. In light of these data, i-PCB concentrations determined in the gas phase were found to be higher than those in the particle phase. In addition, concentration rates determined in summer months were calculated to be higher compared to those calculated for winter months.
- MakaleAçık Erişim2023MW Assisted Synthesis of New 4,6-diaryl-3,4-Didhydropyrimidines-2(1H)-thione Derivatives: Tyrosinase Inhibition, Antioxidant, and Molecular Docking Studies
Yucel, Tayyibe Beyza; Fandaklı, Seda; Yayli, Nurettin; Barut, Burak; Uzuner, Ugur; Öztürk, Elif; Ates, Fatih
A number of new methoxy-substituted 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thiones (DH-Pyr-S, 17-28) were designed and synthesized by the reaction of methoxy-substituted chalcones (1–14) with thiourea using solid-phase microwave method (MW) in view of the structural requirements as suggested in the pharmacophore model for tyrosinase inhibition (TI). Synthesized compounds were assessed for their in vitro TI potential and compounds 16, 17, and 21 exhibited notable tyrosinase inhibitory properties at the concentrations of 31.86 ± 2.45 µM, 44.58 ± 0.46 µM, and 48.47 ± 0.66 µM, respectively. Compounds (16, 17, and 21) were exhibited experimentally more potent TI than the standard used in terms of the IC50 value (Kojic acid, 55.38 ± 2.30 µM; p<0.0001). Additionally, DPPH activity of 15-28 were evaluated and compound 17 showed the moderate DPPH activity (45.64 ± 0.34%). Binding affinities of synthesized molecules to the tyrosinase catalytic core were further investigated through in silico molecular docking studies using AutoDock Vina (version 1.2.5), discovery studio accelyrs (BIOVIA, Dassault Systèmes) and predicting small-molecule pharmacokinetic properties using graph-based signatures (pkCSM) programs were used for ADMET calculations. Among synthesized compounds 15, 21, and 24 revealed high binding affinity to tyrosinase active site with lowest binding free energy (ΔG) values of -7.9 kcal/mol, thereby outperformed kojic acid affinity. In conclusion most modeling results were in agreement with their experimental data, suggesting the TI potential of lead compounds.
AtıfOpenAlex1
İncele - MakaleAçık Erişim2023DERİN ÖTEKTİK ÇÖZÜCÜNÜN Rheum ribes KÖKLERİNDEN FENOLİK BİLEŞİK EKSTRAKSİYONU ÜZERİNE ETKİSİ
Kantar, Naciye Kutlu
Bu çalışmada ışkın bitkisi (Rheum ribes) köklerinden biyoaktif bileşik eldesinde farklı çözücü tipleri değerlendirilmiştir. Yeşil çözücü olarak kolin klorür ve laktik asit ile hazırlanan farklı molar oranda (1:1, 1:2, 1:3) derin ötektik çözücüler ve su kullanılmıştır. Toplam fenolik bileşik miktarı derin ötektik çözücü ile etanol ekstraktına benzer olarak yüksek bulunmuştur. Toplam flavonoid bileşik ekstraksiyonunda en yüksek değer etanol ile elde edilirken ikinci sırada derin ötektik çözücü gelmektedir. Antioksidan aktivite üzerine ise en etkili çözücünün derin ötektik çözücü (1:3) olduğu saptanmıştır. Ek olarak temel bileşen analizi ile farklı çözücüler kullanılarak hazırlanan ışkın ekstraktlarının biyoaktif içerik (toplam fenolik, toplam flavonoid bileşik, antioksidan aktivite) açısından benzerlik/farklılıkları değerlendirilmiştir. Sonuç olarak, ışkından biyoaktif bileşik ekstraksiyonunda organik çözücülere alternatif olarak derin ötektik çözücünün kullanımı uygun bulunmuştur.
AtıfOpenAlex1İncele - Proje2023Derin Ötektik Çözücüler Kullanılarak Arı Ekmeğinden Biyoaktif Bileşenlerin Ultrasonik Destekli Ekstraksiyonunun Optimizasyonu
Kantar, Naciye Kutlu; Bayram, Sinan; Çelik, Saffet; Ecem Bayram, Nesrin; Gerçek, Yusuf Can; Baştürk, Fatma Nur; Yildirim, Nazlican
Arı ekmeği arıların protein kaynağı olarak kullandıkları temel besin maddelerinden birisi olup kovan içeresinde arı poleninin fermantasyonu sonucu oluşmaktadır. Bu ürün fonksiyonel özllikleri sebebiyle son birkaç yıldır arı ürünleri arasında bilinilirliği ve tüketimi artan ürünler arasında yerini almıştır. Bununla birlikte, derin ötektik çözücüler (deep eutectic solvent-DES), değişken viskoziteleri, uygulamaya özel ayarlanabilirlikleri, alev almazlıkları, düşük buhar basınçları ve kimyasal kararlılıkları nedeniyle geleneksel çözücülerin yerini alacak umut verici yeşil alternatifler olarak son yıllarda büyük ilgi görmektedir. Bu nedenle bu çalışmada, arı ekmeği örneği farklı hidrojen bağ alıcısı (HBA):hidrojen bağ donörü (HBD) kombinasyonlarına sahip olan 10 farklı DES?de ekstrakte edilmiş ve en yüksek toplam protein içeriğine sahip DES kombinasyonunun kolin klorid (ChCl)-üre olduğu belirlenmiştir. Daha sonra ChCl-üre ile hazırlanan ekstraktlarda maksimum biyoakif madde ekstraksiyonu için ultrasonik ekstraksiyon koşulları optmize edilmiştir. Yanıt yüzey yöntemi ile yapılan optimizasyon sonucunda optimum koşullar; ultrasonik güç için %31.3, ekstraksiyon süresi için 25 dk ve sıcaklık için 35 °C olarak bulunmuştur. Modelin arzu edilebilirlik değeri ise (d) 0.83 olduğu görülmüştür. Elde edilen ekstraktlarda toplam fenolik madde, toplam protein içerik, bireysel fenolik madde, bireysel amino asit içerik ve bireysel vitamin içerik analzilerinin yanı sıra antioksidan ve antimikrobiyal aktivite testleri gerçekleştirlmiştir. Elde edilen sonuçlara göre toplam protein, toplam bireysel amino asit ve toplam bireysel fenolik içerik, ChCl-üre ile elde edilen ekstraktlarda geleneksel çözücü (etanol) ile hazırlanan ekstrakta kıyasla daha yüksek oranda tespit edilmiştir. Sonuç olarak, elde edilen tüm bu bulgular arı ekmeğinden ekstrakte edilmek istenen hedef bileşiklerin yapısal özelliklerine bağlı olarak ChCl-üre kombinasyonunun etanole alternatif olabileceğini göstermiştir.
- MakaleAçık Erişim2022Effect of Different Roasting Methods on Some Properties of Walnut Kernels
Kantar, Naciye Kutlu; Kamiloğlu, Aybike; Yılmaz, Özlem; Elbir, Tugba
In this study, the effects of oven roasting and microwave roasting on some properties of walnut kernels were determined. Roasting methods at different oven temperatures (70, 100, and 130 ºC for one hour) and at different microwave powers (240, 535 and 830 W for 5 min) were applied to samples. Moisture ratio values, total phenolic compound, antioxidant activity, and oil yield of the roasted and unroasted products were discussed. The highest oil yield was determined in the high temperature oven roasting but the microwave roasting mostly increased the oil yield of the product. Microwave roasting was found to be more suitable for decreasing moisture content. The lowest antioxidant activity was detected with microwave roasting. It was determined that the effect on the amount of phenolic substance in the two methods was indifferent.
AtıfOpenAlex2İncele - MakaleAçık Erişim2021EXTRACTION OF PHENOLIC COMPOUNDS FROM HAWTHORN FRUIT (Creategus monogyna) USING MICROWAVE AND ULTRASOUND ASSISTED METHODS
Kantar, Naciye Kutlu; Yılmaz, Merve Sılanur; Erdem, Gizem Melissa; Şakıyan, Özge; Isci, Asli
In this study, phenolic compounds were extracted from hawthorn fruit using microwave (MAE) and ultrasound assisted extraction (UAE) methods. The MAE was applied at different solids ratios, different extraction times and different microwave powers. UAE was applied at different solids ratios and sonication times. The maceration method was used as the control group. Total phenolic content (TPC) and color values of the extracts were examined. The highest values of TPC were determined as 9.31, 5.34, and 3.00 mg GAE/g dry matter in MAE, UAE, and maceration methods, respectively. Based on these results, it was found that the TPC value of the MAE method was 1.7 and 3.1-fold more than those of UAE and maceration, respectively. In addition, it was observed that L* values of MAE samples were lowest among others. It was concluded that the MAE is the most suitable method for the extraction of phenolic compounds from hawthorn fruit.
AtıfOpenAlex2TR Dizin4İncele - MakaleAçık Erişim2021Osmotic Dehydration Applications in Meat
Kantar, Naciye Kutlu; Kamiloğlu, Aybike; Elbir, Tugba
Osmotic dehydration is a non-thermal, partial drying process applied for the removal of water in food products, as well as for the absorption of various solutes (salt, sugar, etc.). In the osmotic dehydration process, the food material is immersed in a high concentration solution to obtain a final product with lower water activity. However, since the final products with very low water activity cannot be obtained with osmotic dehydration, this method is applied as a pretreatment. The water loss in the product takes place in a shorter time with the osmotic dehydration process applied before drying. The most effective factors on osmotic dehydration are the type of osmotic agent, concentration, process temperature, process time and sample/solution ratio. The low process temperature in osmotic dehydration prevents the loss of color and aroma in food products and contributes the functional, nutritional and sensory properties of products. In addition, the fact that it is a very economical process and does not pose any negative effects in terms of human health makes the method advantageous. In this review, when the osmotic dehydration process is used as a pretreatment in meat processing, the effects on the quality characteristics of the product were mentioned. It has been determined that osmotic dehydration used in various meats (chicken, pork, beef, lamb, ostrich meat and a wide variety of seafood) improves many quality parameters such as color and sensory properties and shelf life of the products. Dried meat with better texture were obtained with the use of specific osmotic agents. It is also recommended to use osmotic dehydration in combination with some applications such as ultrasound or high pressure for effective drying of meat. It was determined that osmotic dehydration process used before convective drying significantly reduced the drying time of meat.
AtıfTR Dizin1İncele - MakaleAçık Erişim2021Investigation of Heavy Metal Pollution in Soil and Plants: The Case of Bayburt Province
Kul, Sinan; Cengiz, İbrahim; Gül, Volkan
Yellow canthron (Hypericum perforatum L.), one of the plants widely used in alternative medicine, is widely grown on highways, but it is unconsciously collected and used for treatment by people without considering the negative effects of environmental pollution. This study was conducted to determine the heavy metal pollution of Hypericum perforatum L., which grows naturally on the roadside in Bayburt province, and the soil where it grows, depending on environmental factors. For this purpose, plant and soil samples were taken from 10 different points along the main connection roads where the Hypericum perforatum L. plant is densely grown and in these samples, using Agilent 7800 ICP-MS brand inductively coupled plasma mass spectrometer, Mg, Cr, Mn, Fe, Co, Ni, The heavy metals of Cu, Zn, Cd and Pb were analyzed. As a result of the analysis of the samples, the highest concentrations were measured for Mg at all sampled points. When the heavy metal content of the plant samples was examined, it was found that other elements except Zn determined at the A9 point on the Bayburt-Erzincan highway were within normal limits, under the influence of the settlements, and when the heavy metal content of the soil samples was examined, it was determined at the A1 and A2 points on the Erzurum-Trabzon highway It has been determined that other heavy metals except Ni are below the limit values. The data obtained show that heavy metal pollution should not be ignored in the province of Bayburt, where there is no industrialization, and that such studies can be used to determine the appropriate natural treatment methods in regions where pollution is increased by repeating certain studies.
AtıfOpenAlex4TR Dizin2İncele - Derleme MakaleAçık Erişim2021Utilization of deep eutectic solvents in the extraction of bioactive compounds from food materials
Kantar, Naciye Kutlu; İşci, Aslı; Yılmaz, Merve Sılanur; Şakıyan, Özge
As the environmental awareness increases, the concept ofgreen technology has gained more importance in recentyears. It aims to reduce the production and consumption ofhazardous materials, reduce the amount of energy spent andincrease the use of renewable resources. It is recommendedto use solvents that have non-toxic and high extractionefficiency instead of traditional solvents that are commonlyused in the food, chemical and pharmaceutical industries.Green solvents are non-toxic, recyclable, non-volatile andhave minimal cost of synthesis. Water, ionic liquids orsupercritical fluids are among the most commonlypreferred green solvents. In addition to these solvents, deepeutectic solvents took a part in this field in recent years.Although the physical properties of deep eutectic solventsare similar to ionic liquids, their chemical properties aredifferent. In recent years, deep eutectic solvents have beenwidely used in the extraction of bioactive compounds(phenolic compound, anthocyanin etc.) from foodmaterials. It has been detected a significant increase inextraction efficiency with these solvents. This articlereviews the extraction of bioactive compounds from foodmaterials using deep eutectic solvents.
AtıfOpenAlex2TR Dizin3İncele - MakaleAçık Erişim2020Determination of Radiation Protection Features of the Ag2O Doped Boro-Tellurite Glasses Using Phy-X / PSD Software
Alım, Bünyamin
This study focused on the radiation protection features of the Ag2O doped boro-tellurite glass samples in the form of (x)Ag2O/(100-x)(65B2O3-35TeO2) where x=10, 15, 20, 25 and 30 mol%. by using Phy-X / PSD software, the radiation protection parameters such as mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), half-value layer (HVL), mean free path (MFP), total atomic and electronic cross-sections (ACS and ECS), effective atomic number (Zeff) , effective electron density (Neff) and effective conductivity (σeff) of present glasses were calculated in the photon energy range of 0.015-15 MeV. In order to evaluation the usability of these glasses in terms of radiation protection, the all investigated protection parameters were also calculated for commercial RS 253 glass and some concretes such as ordinary concrete (OC), hematite-serpenite (HS) and basalt-magnetite (BM) that are commonly used as shielding material in the nuclear application. The results obtained were evaluated in terms of both photon energy and chemical composition of the glasses examined. Additionally, the results obtained for the examined glasses were compared with the corresponding values obtained for the comparison materials presented to determine the best radiation protection glass. It was clearly observed that the MAC, LAC, ACS, ECS and Zeff values increased with the increasing of molar doping percentage Ag2O in the glasses. It was found that the radiation protection capacities of the Ag2O doped boro-tellurite glasses is found higher than the other compared materials. Maximum MAC, LAC, ACS, ECS and Zeff values were observed in the sample of G5 that contains 30% Ag2O. This study indicates that the disilver oxide doped tellurite glasses can be developed as radiation protection materials for many nuclear applications.
AtıfOpenAlex26TR Dizin6İncele - MakaleYalnız künye2020Kaynağından Akdeniz’e Deliçay’ın (Mersin) Debisi ve Su Kalitesinin Değerlendirilmesi
Yıldırım, Ümit; Guler, Cuneyt; Kurt, Mehmet Ali; Güven, Onur
Bu çalışmada, Orta Toroslardaki Güzelyayla (Mersin) yerleşimi yakınlarında doğan ve Akdeniz’e dökülen Deliçay’ın,kaynağı ile boşalım noktası arasında belirlenen 11 farklı lokasyonda, akarsu debisi belirlenmiş ve akış yolu boyunca sukimyasında meydana gelen değişimleri ortaya koymak amacıyla yerinde fiziksel parametre ölçümleri yapılarak suörnekleri alınmıştır. Alınan su örneklerinin majör anyon/katyon ve iz element içerikleri laboratuvarda spektrofotometre,iyon kromatografisi, titrasyon ve ICP-MS yöntemleri kullanılarak analiz edilmiştir. Elde edilen sonuçlar, çeşitli grafikyöntemler kullanılarak değerlendirilmiş ve tarımsal sulama amaçlı kullanıma uygunlukları değerlendirilmiştir.Değerlendirmeler sonucunda; Deliçay’dan alınan tüm su örneklerinin tarımsal sulama amaçlı kullanıma uygun olduğutespit edilmiştir. Akarsu örneklerinde kirlilik göstergesi olabilecek parametrelerin ise havza çıkış noktasına doğru artışgösterdiği ve bu artışın sebebinin tarımda kullanılan çeşitli kimyasallar (gübreler ve tarımsal ilaçlar) ileevsel/endüstriyel atıkların akarsuya kontrolsüz deşarjı olduğu sonucuna varılmıştır.
AtıfOpenAlex10TR Dizin11İncele - MakaleAçık Erişim2019Taguchi deney tasarımı kullanılarak uçucu kül ile ni (ıı) gideriminde bazı adsorpsiyon parametrelerinin etkinliğinin irdelenmesi
Serencam, Hüseyın; Uçurum, Metin
Bu çalışmada, önemli bir sanayi artığı olan Uçucu Külün, toksik bir ağır metal iyonu olarak bilinen Nikel(II)’in sulu çözeltiden adsorpsiyonunda rol oynayan önemli parametrelerden pH, ilk metal konsantrasyonu veadsorpsiyon süresi Taguchi deney tasarımı kullanılarak optimize edilmiştir. Adsorpsiyon deneyleri, L9 ortogonaldizaynına göre 9 adet deney yapılarak gerçekleştirilmiştir. Deney sonuçlarının değerlendirilmesinde varyansanalizi ve sinyal/gürültü oranı kullanılmıştır. Elde edilen sonuçlara göre en iyi uzaklaşma verimi (%); pH 6’da,180 ppm giriş konsantrasyonunda ve 30 dakika adsorpsiyon süresinde elde edilmiştir. Bu çalışma ile birlikte,Taguchi deney tasarımının adsorpsiyon çalışmaları için oldukça uygun bir deney tasarım metodu olduğu veuçucu külün sulu çözeltilerden ağır metal (nikel) gideriminde adsorplama kabiliyetinin iyi olduğu sonuçlarınaulaşılmıştır.
AtıfOpenAlex11TR Dizin9İncele - Proje2016Azot (N), Kükürt (S) ve Bor İçerikli Organik Katkılarla Asfaltın Modifiye Edilerek Asfalt Kaplamaların Mekanik Özelliklerinin İyileştirilmesi
Oruç, Şeref; Yılmaz, Bahadır; Sancak, Kemal
In this study, a novel boron-containing organic additive, which is completely original, was chemically synthesised in the laboratory condition and its performance features on the asphalt were assessed. The structural characterisation of the synthesised organic additive was investigated using nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR) and thermogravimetry (TG) analysis methods. The morphologic structure, modification mechanism and thermal degradation behaviours of modified asphalt binders formed by adding the additive to the asphalt were determined by scanning electron microscopy (SEM), FT-IR and TG analysis. The physical and rheological properties were measured using dynamic shear rheometer (DSR), rolling thin film oven test (RTFOT), rotational viscometer (RV), pressure aging vessel (PAV), bending beam rheometer (BBR) and conventional binder experiments. Mechanical properties of mixtures prepared according to Marshall design were examined by the experiments of Marshall stability and flow, indirect tensile, moisture damage, indirect tensile strength, static creep, dynamic creep, indirect tensile fatigue, LCPC wheel tracking, and Nicholson stripping. The results indicate that the additive increased the asphalt’s consistence, rutting, aging resistance, flexibility, adhesion, loading spreading and fatigue life features and decreased temperature sensibility and cracking tendency at the low temperatures. Statistical analysis of the data obtained from experiments supports those findings, indicating that the best additive ratio to enhance the performance features of asphalt was 6%.