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Koleksiyondaki öğeler
- MakaleAçık Erişim2023Scopus SJRQ2Relation of ATPase6 Mutations and Telomere Length in Schizophrenia Patients
Uzuncakmak, Sevgi Karabulut; Dirican, Ebubekir; Ozcan, Halil; Takim, Ugur
Objective: Schizophrenia is a serious mental disorder. Mutations in mitochondrial genes can change energy metabolism. Telomere is a tandem sequence at the end of chromosomes. Shorter telomere length has been shown in schizophrenia. The aim of this study was to determine the relationship between ATPase6 gene mutations and telomere length in schizophrenia patients. Methods: Blood samples of 34 patients and 34 healthy controls were used. In this study conventional PCR, Sanger sequencing technic and real-time PCR were utilized. Results: Five different mutations (A8860G, A8836, G8697A, C8676T, and A8701G) in the ATPase6 gene were identified in schizophrenia patients. The most seen mutation was A8860G (94%). Telomere length analysis indicated the relation of ATPase6 gene mutations and telomere length variations (p = 0.001). Patients carrying the A8860G mutation had shorter telomere lengths than patients carrying other mutations. Comparing telomere length between schizophrenia patients and healthy controls revealed that the mean telomere length of schizophrenia patients was shorter than healthy controls (p = 0.006). The demographic analysis demonstrated a significant relationship between marital status and telomere length (p = 0.011). Besides that, the duration of the illness is another factor that impacts telomere length (p = 0.044). There is no significant relation between telomere length and other clinical and demographic characteristics including education status, age, gender, etc. Conclusion: In conclusion, telomere length and ATPase6 gene mutations have a significant relation. Studies with larger patient populations and investigation of other mitochondrial gene mutations will make the clearer link between telomere length and mitochondrial mutations.
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- Kitap BölümüYalnız künye2023Information ethics in the context of current developments
Esmer, Yusuf; Aribaş, Ayşe Nihan
The emergence of globalization due to information technologies and the changes and/or developments brought about by globalization require organizations to have more knowledge about ethics and therefore to be more interested in this issue. The use of information and communication technologies in organizations in accordance with ethical values is considered important in terms of the integrity, functioning, and efficiency of both employees and organizations. Individuals, managers, organizations, and researchers have important duties in the field of information ethics in order to prevent the making of difficult mistakes that will adversely affect individuals and organizations during the use of information technologies. In this context, information ethics has been examined in this study in the context of recent developments all over the world, especially the developments in the global COVID-19 pandemic process.
- Derleme MakaleAçık Erişim2024Scopus SJRQ2Review of In Situ Detection and Ex Situ Characterization of Porosity in Laser Powder Bed Fusion Metal Additive Manufacturing
Aydogan, Beytullah; Chou, Kevin
Over the past decade, significant research has focused on detecting abnormalities in metal laser powder bed fusion (L-PBF) additive manufacturing. Effective online monitoring systems are crucial for enhancing process stability, repeatability, and the quality of final components. Therefore, the development of in situ detection mechanisms has become essential for metal L-PBF systems, making efficient closed-loop control strategies to adjust process parameters in real time vital. This paper presents an overview of current in situ monitoring systems used in metal L-PBF, complemented by ex situ characterizations. It discusses in situ techniques employed in L-PBF and evaluates the applicability of commercial systems. The review covers optical, thermal, acoustic, and X-ray in situ methods, along with destructive and non-destructive ex situ methods like optical, Archimedes, and X-ray characterization techniques. Each technique is analyzed based on the sensor used for defect detection and the type or size of defects. Optical in situ monitoring primarily identifies large defects from powder bed abnormalities, while thermal methods detect defects as small as 100 µm and keyholes. Thermal in situ detection techniques are notable for their applicability to commercial devices and efficacy in detecting subsurface defects. Computed tomography scanning excels in locating porosity in 3D space with high accuracy. This study also explores the advantages of multi-sensor in situ techniques, such as combining optical and thermal sensors, and concludes by addressing current research needs and potential applications of multi-sensor systems.
AtıfScopus23WoS22OpenAlex28İncele
- MakaleYayıncıda açık erişim2022Scopus SJRQ2Evaluation of photon interaction parameters of Anti-HIV drugs
Akbaba, Uğur; Şakar, Erdem; Abu Al-Sayyed, Mohammed Ibrahim; Alim, Bünyamin; Özpolat, Özgür Fırat
Medical treatment inevitably exposes individuals to radiation, including those taking drugs used to treat and prevent human immunodeficiency virus (HIV). Motivated by this, we investigated the radiation interaction properties of several HIV drugs to determine the interaction parameters, mass attenuation coefficient (MAC), atomic cross section (ACS), electronic cross section (ECS), effective atomic numbers (Zeff), and effective electron density (Neff). We calculated the values using the Phy-X/PSD software in the range of 0.015–15 MeV. Additionally, we calculated the exposure build-up factor (EBF), and energy absorption build-up factor (EABF) values of the drugs up to 40 mean free path (MFP) using the geometric progression (G-P) method. From our findings, we determined that Combivir, with its relatively high heavy element content, had the highest radiation attenuation capacity, whereas the probability of Lopinavir interacting with photons was the lowest compared with the other drugs. The results of the EBF and EABF parameters, including the scattering effects, ordered the drugs opposite to the primary interaction parameters such as MAC, ACS, ECS, and Zeff. These findings can guide the treatment process of HIV-positive patients and inform HIV prevention practices conducted alongside radiotherapy, as the interaction between radiation and a drug may cause deterioration in the drug's structure.
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- Kitap BölümüYalnız künye2024Factors affecting tourists' sustainable tourism intention: A parallel mediation analysis
Apak, Ömer Ceyhun; Ünlü, Hami
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- MakaleYalnız künye2024Scopus SJRQ2Optimization, Characterization, and Carbon Footprint Analysis of Alkali Activated Waste Tuff and Fly Ash Mixtures for Deep Mixed Columns
Kamiloğlu, Hakan Alper; Yilmaz, Fatih
Deep soil mixing (DSM) applications are one of the widely known soil stabilization techniques which can be applied to a wide range of soil types. Cement and lime are the major materials used as binders for DSM applications. However, as conventional binders lead to emit a large amount of CO2 during production, eco-friendly binders suitable for DSM applications have become prominent. Alkali-activated materials are good alternatives to conventional binders. This study was intended to investigate the usability of zeolite rich tuff wastes as an alkali-activated binder in DSM columns. Within this scope, the waste tuff and C-type fly ash mixture were used as an alkali-activated binder, and 10 M NaOH solution was used as an activator. Response surface methodology (RSM) was employed in experimental design to determine optimum components to obtain maximum unconfined compression strength and investigate the interaction between stabilization agents. From the RSM analysis the optimum ratios of activator (X1), waste tuff (X2), and precursor (X3) were determined as; X1 = 0.251, X2 = 0.548, and X3 = 0.538 for maximum UCS. UCS, mineralogical and microstructural characterization (XRF, XRD, SEM, EDX, FTIR) was performed for the DSM samples prepared considering the optimized components. It was determined that the UCS values of the 3, 7, and 28-day cured samples stabilized by considering the optimum values gave UCS values approximately 3 to 5 times higher than the lower limit values recommended by FHWA. As a result of mineralogical and microstructural investigation, the reason for the strength increase in the samples can be attributed to the formation of geopolymeric gel between the soil particles by tuff waste and fly ash activated with alkaline activator. Carbon footprint analyses were performed for 1m3 DSM columns produced with alkali-activated binders and ordinary Portland cement (OPC). From the analyses it was seen that the carbon footprint of the DSM column produced using alkali activated binders is lower than that of the DSM column obtained with OPC. After the general evaluation of the study, it is seen that the hypothesis that waste tuff can be used as environmentally safe alkali-activated binders instead of traditional binders is supported.
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- MakaleAçık Erişim2022Scopus SJRQ1Charity Social Media Marketing and Its Influence on Charity Brand Image, Brand Trust, and Donation Intention
Bilgin, Yusuf; Kethüda, Önder
This study aims to identify the outline of charity social media marketing (SMM) and to determine to what extent it influences the charity brand image, brand trust, and donation intention. The data were gathered from followers of internationally operating Turk charities on social media. The theoretical model and hypotheses were tested by using structural equation modeling. Charity SMM is composed of awareness, interaction, timeliness, informativeness, customization, and advertisement dimensions. Awareness is the only dimension of SMM that has a significant direct influence on donation intention. Timeliness, informativeness, and advertisement significantly influence charity brand image, whereas brand trust is influenced by informativeness and customization. Besides, Charity SMM, as a whole, influences donation intention both directly and indirectly through brand image and brand trust. Therefore, charity brand image and brand trust are crucial for charities to promote donation intention through SMM. Therefore, charities are strongly recommended to focus primarily on developing their brand image and gaining trust in current and prospective donors.
AtıfScopus63WoS49OpenAlex69İncele
- MakaleAçık Erişim2025Scopus SJRQ2SOME NEW INEQUALITIES FOR DIFFERENTIABLE ARITHMETIC-HARMONICALLY CONVEX FUNCTIONS
Kadakal, Mahir; Agarwal, Praveen; İŞcan, İMdat
In this study, by using an integral identity together with both the Hölder and the power-mean inequalities for integrals we establish several new inequalities for differentiable arithmetic-harmonically-convex function. Also, we give some applications for special means.
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- MakaleYalnız künye2024Scopus SJRQ3Social Dominance Orientation and Consumer Xenocentrism: Mediating Role of Status Consumption and Social Comparison
Celik, Bilal; Ercis, Aysel
This research aims to create a model that elucidates the reasons why people exhibit xenocentric consumer tendencies. In this context, a theoretical framework describing the evolution of consumer xenocentrism (C-XEN) was constructed by integrating elements from diverse theories. Then developed model was analyzed with empirical research involving 534 participants using structural equation modeling (SEM) with AMOS. The findings indicate that individuals with high social dominance orientation are more prone to having C-XEN, and proposes that status consumption and social comparison mediates the relationship between the social dominance orientation and the emergence of C-XEN. The framework allows to grasp the psychological factors contributing to C-XEN. In conclusion, testable propositions that are verifiable are believed to promote additional researches on the matter going forward.
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- MakaleYalnız künye2024Scopus SJRQ2Metacognitive training for algebra teaching to high school students: An action research study
Okumuş, Özlem; Öztürk, Mesut
Metacognition is an essential concept in mathematics education research. Studies indicate that high school students in Turkey must demonstrate expected success in learning mathematics in general and algebra in particular. To this end, the Ministry of National Education has initiated a mathematical mobilization in Turkey. Mathematics mobilization is a project that will adapt the learning of mathematics to daily life skills, making learning more accessible and ensuring that students love this course from an early age. In the initial interviews with teachers as part of this mobilization, teachers stated that high school students needed to exhibit sufficient metacognitive planning and monitoring strategies. Therefore, they required assistance in planning and monitoring their learning processes and motivating them to learn. The literature shows that metacognitive planning and monitoring are effective in teaching algebra. In this context, the research “How can metacognitive strategies be developed in high school students’ algebra learning?” seeks an answer to this problem. Based on preliminary teacher interviews, the researchers created action plans in collaboration with teachers. In the circular model, researchers tested these action plans and revised them. As a result of the cycle being repeated three times, researchers developed a teaching technique based on metacognitive planning and monitoring for high school students. The study's findings demonstrate that metacognitive training taught students metacognitive planning, monitoring, prediction, awareness, and motivation strategies.
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- MakaleAçık Erişim2023Scopus SJRQ2Investigation of the effects of changes in formulation and cooking times on the quality parameters in the production of goji berry leather
Maraş, R. Talay; Erdoğan, U.
Goji berry (Lycium barbarum L.) is described as a food with several health benefits. This valuable fruit has been processed into fruit leather, which is one of the important traditional products. This study allowed us to determine the effect of changing formulations (starch and flour) and cooking times (10, 15, and 20 min) on quality criteria during goji berry leather production. The goji berry leather samples exhibited the following characteristics: pH values ranging from 4.96 to 4.99, titration acidity values spanning from 2.97% to 3.23%, dry matter content within the range of 84.78% to 87.69%, ash content between 3.12%, and 4.27%, water activity (aw) values ranging from 0.37 to 0.38, protein content between 14.71%, and 15.66%, HMF content varying from 17.33 mg/kg to 34.51 mg/kg, total phenolic content ranging from 7.14 µg GAE/g to 7.89 µg GAE/g, total sugar content falling between 61.18%, and 63.89%, reducing sugar content within the range of 60.13% to 61.89%, sucrose content ranging from 0.91% to 2.25%, thickness values ranging from 0.74 mm to 0.89 mm, hardness values varying between 17.09, and 33.27, stickiness values within the range of 4.10 to 23.34, cohesiveness values from 0.85 to 1.00, elasticity values ranging from 0.88 to 0.97, chewability values spanning from 12.85 to 30.85, L* values ranging from 27.27 to 32.66, a* values between 8.62, and 10.32, b*values varying from 7.06 to 8.59, C* values within the range of 11.15 to 12.81, and H° values falling between 39.31, and 41.13. Following the sensory evaluation of leather samples, it was determined that the color score ranged from 3.80 to 4.27, the smell score fell between 3.53 and 4.00, the taste score varied from 2.93 to 4.00, the mouthfeel score ranged from 2.93 to 3.93, and the general acceptability score was found to be within the range of 3.27 to 4.20. It was determined that cooking time and additional additives affect some quality values of the goji berry leather.
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- MakaleAçık Erişim2023Scopus SJRQ2Evaluation of IGFBP5 expression and plasma osteopontin level in COVID-19 patients
Karabulut Uzunçakmak, Sevgi; Aksakal, Alperen; Kerget, Ferhan; Aydın, Pelin; Halıcı, Zekai
Purpose: The aim of this study is to investigate insulin-like growth factor binding protein 5 (IGFBP5) expression in coronavirus disease 2019 (COVID-19) patients and its relationships with COVID-19 laboratory findings and plasma osteopontin (OPN) levels. Materials and methods: We enrolled 60 patients with COVID-19 and 30 healthy individuals in this study. mRNA expression of IGFBP5 was measured by RT-PCR. Plasma OPN levels were measured via the ELISA method. Results: Plasma OPN levels were higher and IGFBP5 expression levels were lower in COVID-19 patients than in the healthy individuals (p = 0.0057 and p = 0.0142, respectively). Critically ill patients had higher OPN and lower IGFBP5 than non-critically ill patients. Patients with affected lungs demonstrated increased OPN and decreased IGFBP5 (p = 0.00032 and p = 0.044, respectively). Receiver operating characteristic (ROC) analysis indicated that IGFBP5 expression and OPN levels can be used discriminate non-critically from critically ill patients (p = 0.049; p = 0.0016, respectively). Conclusion: This study demonstrated that patients with a poor prognosis had increased OPN and decreased IGFBP5. High values of OPN and low values of IGFBP5 may be considered as signs of disease severity. Tissue-specific IGFBP5 expression may contribute to understanding the role of IGFBP5 in the lungs in COVID-19 cases.
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- MakaleYalnız künye2023Scopus SJRQ1Nectar honey from Turkey: crystallization and physicochemical profile
Ecem Bayram, Nesrin
Honey is a traditional food used by humans due to many therapeutic properties. Turkey is in a good position for the production of bee products, and honey is the most popular bee product in the country. In this study, the aim was to evaluate the quality parameters of 40 honey samples based on physicochemical parameters and to gain information about speed of crystallization. For this purpose, moisture (%), fructose (%), glucose (%), fructose + glucose (F + G, %), fructose/glucose (F/G), glucose/moisture (G/M), and proline (mg/kg) contents were determined in honey samples and cluster analysis was performed. When the sugar profile of honey samples is examined, F + G was 61.63–78.03%, F/G was 0.99–1.25, moisture content was 14.9–19.1%, and proline content was 384.41–1271.56 mg/kg. These results comply with national standards. Honey samples tend to crystallize quickly when their crystallization properties are evaluated based on F/G and G/M ratios. Consequently, the quality of honey differs according to the region from which it is produced and it is natural for honey to crystallize.
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- MakaleYalnız künye2024Scopus SJRQ3Facile biomimetic synthesis of AgNPs using aqueous extract of Helichrysum arenarium: characterization and antimicrobial activity
Yilmaz, Mustafa Tahsin; İspirli, Humeyra; Taylan, Osman; Balubaid, Mohammad; Dertli, Enes
The present study focuses on synthesis of silver nanoparticles (AgNPs) by employment of a green and facile synthesis method. Aqueous extract of Helichrysum arenarium was used as a reducing and capping agent. The bioreduction of silver particles was monitored using UV–Vis spectroscopy based on increase in color intensity led by surface plasmon resonance. SEM, TEM, FTIR, DSC, and XRD analyses were followed for characterization, divulging that the nanoparticles were thermally resistant in the size of approximately 20 nm with a quasi-spherical shape without any agglomeration. AgNPs possessed a nanocrystal form with presence of crystalline Ag. EDAX analysis was used to verify that the nanoparticles were silver as revealed by a typical optical absorption peak of metallic silver nanocrystallites. The AgNPs were shown to have strong antibacterial and antifungal effects on some foodborne pathogens. The method developed in this study could offer a green, facile biomimetic, and cost-effective method.
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- Kitap BölümüYalnız künye2024Sensory analysis and consumer acceptance of legume-based gluten-free bakery products
Erten, Edibe S.; Erten, Tayyibe
The replacement of gluten is essential for the development of gluten-free foods. To achieve this, variety of flours (such as corn flour, chestnut flour, and buckwheat flour) have been investigated by food scientists. Legume flours seem preferable to other flours among these gluten-alternative sources due to their nutritional quality. In this chapter, recent developments in legume-based gluten-free bakery products were investigated. Due to their high protein content, legumes have numerous applications in the gluten-free food industry. However, undesirable flavor formation limits their widespread usage. For this reason, the effects of replacing gluten-containing ingredients with legumes on the sensory properties and consumer acceptance were discussed as the main focus of this chapter.
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- MakaleAçık Erişim2023Performance Analyses of Combined Cycle Power Plants
Karaali, Rabi
In this article, different compressor pressure and different excess air rates for a gas turbine based combine cycle power plant with steam Rankine cycle as bottoming cycle were analyzed by using 1. and 2. laws of thermodynamics and exergy analyses methods to obtain the best performances of the cycle. Exergy efficiency of the cycle, net powers of the gas and steam turbines and the overall cycle, exergy loss of the components, the efficiencies of the components are obtained, compared and discussed. It was found that, increasing the compressor pressure increases exergy efficiency of cycle, gas turbine and total plant power, and the combustion chamber, the HRSG and the compressor efficiencies. However, increasing compression rates decreases steam turbine power, combustion chamber, steam turbine, and HRSG exergy losses and the gas turbine efficiency. Also, it is found that, increases in excess air ratios gives an optimum or a maximum exergy efficiency, at 2.5 excess air rate of the cycle.
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İncele - MakaleAçık Erişim2024Scopus SJRQ1Are students with high creativity skills successful writers? A parallel mediation model
Sarikaya, Ismail
The relationship between creativity and writing success is a matter of curiosity for many researchers, educators, and people in general. Many would likely expect that creative individuals would have higher writing success. This study aimed to determine the mediating roles of writing self-efficacy, writing motivation, and writing disposition in the relationship between creativity and writing success of primary school students. A relational research model was used in the study conducted with 300 primary school students. Correlational analysis and mediating variable analysis were performed with the data obtained with five data collection tools. The analysis results showed significant relationships between the variables: Creativity, writing self-efficacy, writing motivation, and writing disposition were found to significantly predict writing success. In addition, the findings revealed that writing self-efficacy, motivation, and disposition each have a parallel mediating role between creativity and writing success. The study's results are discussed in connection to the pertinent research literature, and recommendations are made.
AtıfScopus5WoS4OpenAlex4İncele
- MakaleAçık Erişim2023Scopus SJRQ2Efficient production of acetone butanol ethanol from sole fresh and rotten potatoes by various Clostridium strains
Avcı, Ayşe; Kamiloğlu, Aybike; Dönmez, Sedat
This study aimed to evaluate rotten potato in the fermentation of acetone butanol ethanol (ABE). For this purpose, three strains, Clostridium acetobutylicum DSMZ 1731, Clostridium acetobutylicum DSMZ 6228, and Clostridium beijerinckii DSMZ 6422, were used and production experiments were performed in a simple media only composed of either fresh or rotten potato. Effects of potato concentration (100–400 g/L) and time (24–144 h) on the fermentation were determined using fresh potato. The highest ABE production was detected at 400 g/L potato concentration at the end of 96 h by all strains. Clostridium acetobutylicum DSMZ 6228 was the most efficient strain in producing ABE among the microorganisms tested. Total ABE productions by Clostridium acetobutylicum DSMZ 1731, Clostridium acetobutylicum DSMZ 6228, and Clostridium beijerinckii DSMZ 6422 at 400 g/L in 96 h were 12.3, 17.6, and 12.0 g/L, respectively. The majority of the products was butanol that made up ca. 66–67% of total ABE. Significant amounts of ABE were also produced with rotten potato which was compatible with the results obtained with fresh potato. They were determined as 11.5, 17.1, and 9.6 g/L with Clostridium acetobutylicum DSMZ 1731, Clostridium acetobutylicum DSMZ 6228, and Clostridium beijerinckii DSMZ 6422, respectively. The results showed that rotten potato could be a good candidate as substrate for ABE fermentation.
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- MakaleYalnız künye2023Scopus SJRQ2Optimization of microwave-assisted biosynthesis of silver nanoparticle with tarragon extract
Altuncu, Fatma Kübra; Kamiloğlu, Aybike
Response surface method was used to optimize microwave-assisted silver nanoparticle production with tarragon extract. As a result of the optimization study, tarragon silver nanoparticles (TAgNPs) were produced from 43 conditions with a degree of desirability of 1, with a processing time of 5.25 min, AgNO3 concentration of 9.89 mM, and tarragon extract concentration of 14.80%. Among the variable parameters, AgNO3 concentration affected TAgNP synthesis depending on processing time and tarragon extract concentration; tarragon extract concentration was found to significantly affect nanoparticle formation. TAgNP produced under optimum conditions was found to be crystalline, with a spherical surface morphology and an average particle size of 16.56 nm, with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction diffractometry (XRD) analyses. TAgNPs showed inhibitory effect for Escherichia coli BC 1402, Bacillus cereus BC 6830, Salmonella typhimurium RSSK 95091, Yersinia enterocolitica ATCC 27729, and Staphylococcus aureus ATCC 25923 microorganisms. The minimum inhibition concentrations were 10 µg/mL for B. cereus BC 6830, 50 µg/mL for E. coli BC 1402, S. typhimurium RSSK 95091, and Y. enterocolitica ATCC 27729, and 25 µg/mL for S. aureus ATCC 25923.
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- MakaleAçık Erişim2024Scopus SJRQ3Effect of Calcium Lignosulfonate Additive on Some Physical and Mechanical Properties of High-Density Fiberboard
Çamlibel, Osman; Ayata, Ümit; Peker, Hüseyin
Calcium lignosulfonate (CLS) (C20H24CaO10S2) is widely used in various industries today, including wood, construction, food, agriculture, and textiles. There are currently few studies on the addition of CLS chemicals to various fiberboards. This study was designed to explore the outcomes of the interaction between CLS and the boards, with the aim of expanding the potential applications of this chemical. We incorporated CLS at varying percentages (6%, 8%, and 10%) as an adhesive ad-ditive in high-density fiberboard (HDF) produced using urea-formaldehyde (UF) resin in a labor-atory setting. We assessed its impact on several physical properties - thickness swelling (TS), den-sity, and water absorption (WA) - and mechanical properties: modulus of rupture (MOR), internal bond strength (IB), modulus of elasticity (MOE), and surface soundness (SS). A control group was created using prepared boards, enabling the comparison of results between boards made with and without CLS additives. According to the results of a multivariate analysis of variance, the CLS per-centage showed no significant effect on density, MOE, and SS. However, it significantly influenced TS, WA, IB, and MOR, resulting in reductions of 4-12% for SS, 6-12% for MOR, and 2-22% for IB, while increasing TS by 20-130%, WA by 25-84%, and MOE by 1-3%. It was observed that the use of CLS led to differing results in the tests conducted on the produced HDF materials.
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