Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Can, Zehra(8)
- Kara, Yakup(5)
- Kolayli, Sevgi(4)
- Kolaylı, Sevgi(4)
- Ecem Bayram, Nesrin(3)
- Bayram, Nesrin Ecem(2)
- Bayram, Sinan(2)
- Gerçek, Yusuf Can(2)
- Sorkun, Kadriye(2)
- Çakmak, Ibrahim(2)
- Öz, Gül Cevahir(2)
- Akçay, Çağlar(1)
- Ay Şal, Fulya(1)
- Ayata, Ümit(1)
- Balwierz, Radoslaw(1)
- Beldüz, Ali Osman(1)
- Birinci, Emre(1)
- Cevahir Oz, Gul(1)
- Czuba, Zenon P.(1)
- Ecem-Bayram, Nesrin(1)
- Esertaş, Ülkü Zeynep(1)
- Gercek, Ynsuf Can(1)
- Gurgen, Ayşenur(1)
- Güler, Halil İbrahim(1)
- Inal, Neşe(1)
- Karabulut, Ercan(1)
- Karlıdağ, Semiramis(1)
- Keskin, Merve(1)
- Keskin, Şaban(1)
- Klósek, Malgorzata(1)
- Kurek-Górecka, Anna(1)
- Olczyk, Pawel(1)
- Pietsz, Grazyna(1)
- Salih, Bekir(1)
- Saroğlu, Öznur(1)
- Serencam, Huseyin(1)
- Sevin, Sedat(1)
- Topçu, Gülaçtı(1)
- Toğar, Başak(1)
- Tunca, Erol(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ1Gastrointestinal stability and bioactivity of propolis from diverse origins
Can, Zehra; Çelebi, Zeynep Berin; Tunca, Erol; Kolaylı, Sevgi; Sevin, Sedat; Tutun, Hidayet
Propolis is a chemically complex bee product whose biological properties depend on its botanical and geographical origin. However, little is known about how gastrointestinal digestion affects its phenolic profile and bioactivity. In this study, twelve propolis samples from eight countries were evaluated for phenolic and flavonoid contents, antioxidant capacity (FRAP, ABTS+•), and urease inhibition before and after simulated gastric digestion. RP-HPLC–PDA identified 26 phenolic compounds showing substantial compositional diversity. Turkish Bolu propolis retained the highest post-gastric FRAP value, while several samples (BBP, AFP) maintained or enhanced urease inhibition. PCA and HCA highlighted origin-dependent differentiation, identifying digestive stability as a key variable for functional potential.
AtıfOpenAlex2
İncele - MakaleAçık Erişim2025Scopus SJRQ2A Promising Antibacterial Inhibition of Propolis Extracts Against Carbapenem-Resistant Bacteria Isolated From Clinical Samples
Esertaş, Ülkü Zeynep; Inal, Neşe; Can, Zehra; Kolaylı, Sevgi
The increasing inadequacy of antibiotics against multidrug-resistant pathogens is a growing concern. In this study, the antibacterial activity of propolis extracts with different phenolic profiles against carbapenem-resistant clinical isolates was investigated. The antimicrobial activity of propolis extract was tested against Acinetobacter baumannii (K17, K16, and K21), Klebsiella pneumoniae (K22, and K19), and Stenotrophomonas maltophilia (E5, E7, and E4) bacterial strains isolated from tracheal aspirate and blood cultures. The total phenolic content and phenolic composition of the extracts were analyzed. Antimicrobial activity values examined according to the disk diffusion method were measured as minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The results showed that all propolis extracts showed different inhibition values against bacterial strains. As a result, the high inhibitory potential of the propolis extracts against resistant bacteria such as A. baumannii, K. pneumoniae, and S. maltophilia is promising for combating infections. However, the study needs to be supported by further randomized clinical studies.
AtıfScopus2WoS2OpenAlex4
İncele - MakaleAçık Erişim2024Scopus SJRQ2Antioxidant activity and phenolic composition of propolis from Marmara region, Turkey
Can, Zehra; Kara, Yakup; Kolayli, Sevgi; Çakmak, Ibrahim
This study investigated various properties of raw propolis samples from Marmara region of Turkey. Total phenolic content (TPF), total flavonoid (TFC) values, condensed tannin content (CTC) and phenolic profiles of ethanolic extracts (70%) were analyzed. Antioxidant activities were tested using the Ferric (III) reduction/antioxidant capacity (FRAP) and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging methods. Phenolic profiles of the samples were analyzed using high performance liquid chromatography (RP-HPLC-UV) method. TPC, TFC and CTC values in the samples ranged from 52.9 to 203.5 mg GAE/g, 13.6 to 43.9 mg QUE/g, and 2.0 and 2.9 mg CTE/g, respectively. Caffeic acid phenyl ester (CAPE), chrysin, pinocembrin, rutin, and t-cinnamic acid were detected as the common phenolic components in all samples. In conclusion, Marmara region propolis is a rich source of bioactive compounds, especially flavonoids with antioxidant properties.
AtıfScopus14WoS12İncele - MakaleAçık Erişim2023Scopus SJRQ1The Phenolic Profile and Anti-Inflammatory Effect of Ethanolic Extract of Polish Propolis on Activated Human Gingival Fibroblasts-1 Cell Line
Kurek-Górecka, Anna; Klósek, Malgorzata; Pietsz, Grazyna; Czuba, Zenon P.; Kolayli, Sevgi; Can, Zehra; Balwierz, Radoslaw; Olczyk, Pawel
Propolis, owing to its antibacterial and anti-inflammatory properties, acts as a cariostatic agent, capable of preventing the accumulation of dental plaque and inhibiting inflammation. The anti-inflammatory properties of propolis are attributed to caffeic acid phenethyl ester (CAPE), which is present in European propolis. The objective of the conducted study was to assess the anti-inflammatory effects of the Polish ethanolic extract of propolis (EEP) and isolated CAPE on stimulated with LPS and IFN-alpha, as well as the combination of LPS and IFN-alpha. The cytotoxicity of the tested compounds was determined using the MTT assay. The concentrations of specific cytokines released by the HGF-1 cell line following treatment with EEP (25-50 mu g/mL) or CAPE (25-50 mu g/mL) were assessed in the culture supernatant. In the tested concentrations, both CAPE and EEP did not exert cytotoxic effects. Our results demonstrate that CAPE reduces TNF-alpha and IL-6 in contrast to EEP. Propolis seems effective in stimulating HGF-1 to release IL-6 and IL-8. A statistically significant difference was observed for IL-8 in HGF-1 stimulated by LPS+IFN-alpha and treated EEP at a concentration of 50 mu g/mL (p = 0.021201). Moreover, we observed that CAPE demonstrates a stronger interaction with IL-8 compared to EEP, especially when CAPE was administered at a concentration of 50 mu g/mL after LPS + IFN-alpha stimulation (p = 0.0005). Analysis of the phenolic profile performed by high-performance liquid chromatography allowed identification and quantification in the EEP sample of six phenolic acids, five flavonoids, and one aromatic ester-CAPE. Propolis and its compound-CAPE-exhibit immunomodulatory properties that influence the inflammatory process. Further studies may contribute to explaining the immunomodulatory action of EEP and CAPE and bring comprehensive conclusions.
AtıfWoS17OpenAlex19İncele - MakaleYalnız künye2023Scopus SJRQ1Comparison of bioactive constituents by HPLC–DAD–ESI-MS and UFLC and in vitro antioxidant activities of blossom honey, bee pollen, and propolis
Saroğlu, Öznur; Ecem Bayram, Nesrin; Özçelik, Beraat
The aim of this study was to analyze the total phenolic content, phenolic profile, and antioxidant activity of honey, bee pollen, and propolis samples from Turkey's Black Sea Region. The total phenolic content of these bee products was found using Folin–Ciocalteu's method, and their antioxidant capacity was found using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cupric ion reducing antioxidant capacity (CUPRAC) assays. Phenolic compounds of honey samples were characterized by high-performance liquid chromatography coupled to a photodiode array detector and mass spectrometer (HPLC–DAD–ESI-MS), while phenolic compounds of bee pollen and propolis samples were quantified ultra-fast liquid chromatography (UFLC). The total phenolic values for honey, bee pollen and propolis were 6.32–18.21 mg GAE/100 g, 547.64–769.4 mg GAE/100 gr, and 6096.1–11,564 mg GAE/100 gr, respectively. DPPH and CUPRAC values of honey, pollen and propolis were 11.05–21.38% and 0.38–1.48 µmol Trolox/g; 24.67–38.63% and 0.03–0.05 mmol Trolox/g; 11.81–34.12% and 0.47–0.89 mmol Trolox/g, respectively. About 30 different phenolic compounds were identified as quantitative. Our findings have shown that all bee products examined in the study are found to contain gallic acid, naringenin, and caffeic acid. In terms of total phenolic content and antioxidant activity, the bee product extracts were ranked as follows: propolis > bee pollen > honey. The high concentration of phenolic compounds in propolis explains its remarkable antioxidant effect.
AtıfScopus10WoS10OpenAlex10İncele - MakaleAçık Erişim2023Scopus SJRQ1Palynological, chemical, antimicrobial, and enzyme inhibition properties of Cannabis sativa L. propolis
Özkök, Aslı; Karlıdağ, Semiramis; Keskin, Merve; Bayram, Sinan; Keskin, Şaban; Karabulut, Ercan; Çiçek, Fevzi; Yılmaz, İsmet
In this study, both chemical characterization and biological activities of propolis samples obtained from Cannabis sativa L. (cannabis, hemp, marijuana) isolated colonies (research group) and obtained from colonies at a distance where the bee cannot fly to the isolation area (control group) were determined. Palynological analyses of propolis samples obtained from the research and control group colonies were made and the botanical origin of the cannabis plant and other plants in the research area and the plants in the control group were determined. Bioactive component analysis of propolis extracts was determined by the GC–MS technique. The inhibition effect of propolis samples on some enzymes of medical importance and their antimicrobial effects against many pathogenic microorganisms were also investigated. Palynological analyses showed that honey bees prefer cannabis plants (11.11%) when collecting propolis, and the dry matter percentage (94.6 ± 1.8%), balsam (46.2 ± 5.2%), and wax content (4.8 ± 0.5%), total phenolic (26.44 ± 1.08 mg GAE/mL) and total flavonoid (2.03 ± 0.11 mg QE/mL) content and antioxidant capacity (88.16 ± 2.27 μM FeSO4·7H2O/mL−1) of the research group propolis samples containing hemp were found to be higher than the control group. Also, it was determined that the research group propolis sample contains cannabinoid derivatives (cannabidivarinic acid, 0.29%; delta (1)-tetrahydrocannabinolic acid, 0.59%; cannabidiolic acid, 0.48%), which are active compounds of the cannabis plant. Also, a high inhibition effect was detected on some enzymes of medical importance in propolis samples obtained from cannabis group colonies. In addition, the research group propolis samples also showed a high antimicrobial effect against many pathogenic microorganisms.
AtıfScopus5WoS5OpenAlex4İncele - MakaleAçık Erişim2022Scopus SJRQ4Some Physical, Biological, Hardness, and Color Properties of Wood Impregnated with Propolis
Akçay, Çağlar; Ayata, Ümit; Birinci, Emre; Yalçın, Mesut; Kolaylı, Sevgi
Propolis is a bee product collected by honeybees from various tree species in nature. It has antifungal, antibacterial, antioxidant, and anticancerogenic properties. Recently, propolis has been used in wood protection area because it has antifungal properties and is a natural and environmentally friendly material. In this study, some deciduous wood species were treated with methanolic propolis extracts. Propolis solutions were prepared by dissolving propolis in methanol in concentrations of 0.5%, 2.5%, 5%, and 8%. These solutions were forced deep into the Scots pine (Pinus sylvestris L.), fir (Abies nordmanniana), and spruce (Picea orientalis L.) woodblocks under vacuum and pressure. Water uptake and water-repellent efficiencies of the woodblocks were tested at 2-, 4-, and 20-hour immersion periods. Sample blocks were tested against wood-destroying house borer (Hylotrupes bajulus) (Coleoptera, Cerambycidae) larvae for 21 weeks. In addition, color changes of woodblocks treated with propolis were determined. According to results obtained in the study, the highest water-repellent efficiency was 61.4% in propolis-impregnated spruce wood at concentration level of 8% during the 2-hour period. These results show that propolis extracts could be used as hydrophobic material for wood. Larvae mortality rates indicated that 8% concentration level was not adequate to overcome H. bajulus larvae or propolis is not effective against H. bajulus larvae. While L* value decreases with the increase of impregnation rate, a* and b* values increase in all wood types. As the impregnation rate increased, the total color difference also increased.
AtıfScopus2WoS2TR Dizin1
İncele - MakaleAçık Erişim2022Scopus SJRQ2What Should Be the Ideal Solvent Percentage and Solvent-Propolis ratio in the Preparation of Ethanolic Propolis Extract?
Kara, Yakup; Can, Zehra; Kolaylı, Sevgi
The biological activity of propolis is mostly due to its polyphenols. Raw propolis is consumed after being extracted in various solvents, ethanol being the most commonly used. However, the ideal percentage and ratio of ethanol for use in the preparation of propolis extracts are uncertain. The aim of this study is to compare the phenolic compositions and antioxidant activities of propolis extracts extracted with different ethanol concentrations and extraction conditions. Two different extraction methods were used, normal and ultrasonic extraction. The propolis extracts were evaluated in terms of total phenolic content, total flavonoid content, ferric reducing/antioxidant power,1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, and phenolic compositions using RP-HPLC–PDA. The propolis extracts with the highest activity were determined beforehand by preparing ethanol–water mixtures at different percentages, ranging from 0 to 99.9%. The most suitable propolis-to-solvent ratio was then determined. The optimum ethanolic percentage varied between 60 and 70%, the ultrasonic extraction process increased the efficiency, and the ideal solvent-propolis ratio (w/v) ranged between 1:5 and 1:10.
AtıfScopus39WoS33İncele - MakaleAçık Erişim2022Scopus SJRQ4DETERMINATION OF ANTI-UREASE ACTIVITY OF PROPOLIS FROM MARMARA REGION OF TURKEY; [Türkiye'nin Marmara Bölgesinden Elde Edilen Bazi Propolislerin Anti-üreaz Aktivitesinin Belirlenmesi]
Can, Zehra; Kara, Yakup; Kolayli, Sevgi; Çakmak, Ibrahim
Propolis is a natural product collected by honeybees from plants especially flowers and buds by mixing with wax and resin and used for many purposes in hive. It is known that propolis has been used in the treatment of various diseases in traditional medicine for many years and has biological activities such as antioxidant, antimicrobial, antiulcer, antitumor, anti-inflammatory. There is increasing interest in alternative approaches to inhibit Helicobacter pylori (H. pylori) and thereby treat many gastric diseases. This study investigated various properties of raw propolis samples from the Marmara region of Turkey. Anti-urease activity was investigated in propolis samples. The anti-urease activity of IC50 values ranged from 1.110 to 5.870 mg/mL. As a result, it can be said that propolis extract is a good inhibitor that can be used in the treatment of H. pylori to improve human health.
AtıfScopus4OpenAlex4TR Dizin2İncele - MakaleAçık Erişim2021Scopus SJRQ3Optimization of Extraction Parameters of Ethanol Extracts of Propolis Samples Using Artificial Neural Network and Moth-Flame Optimization Algorithm
Gurgen, Ayşenur; Serencam, Huseyin; Kara, Yakup; Can, Zehra; Ylldlz, Sibel
In this study, the optimum values of propolis ethanol extracts parameters were determined with the use of single and multi-objective optimization procedures. The euclidean distance approach was used in the multi-objective optimization process. Firstly, propolis was extracted using water with ethanol contents 40, 50, 60, 70 and 80% for 8, 10, 12, 16, 20 and 24 h. Then, total phenolic content (TPC) and ferric reducing antioxidant power (FRAP) activities of all extracts were determined. With the obtained data a prediction model was produced with the use of artificial neural networks (ANN), and optimization was performed using a moth-flame (MFO) algorithm. The best prediction models for the TPC and FRAP were observed in 2-5-1 and 2-5-1 network architecture with the mean absolute percentage error (MAPE) values, 5.126 and 2.451%, respectively. For maximum TPC, the extraction parameters were determined as ethanol content 57.5% and extraction time 13.56 h. To maximize FRAP, the optimized extraction parameters were ethanol content 72.03% and extraction time 18.04 h. The optimum extraction conditions for both maximum values of the studied assays were ethanol content 70.03% and extraction time 16.93 h. The study concluded that the integrated ANN and MFO algorithm system can be used in single and multi-objective optimization of extraction parameters. The established optimization model can save time, money, labor and energy.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2021Scopus SJRQ2Targeting cov-2 spike rbd and ace-2 interaction with flavonoids of anatolian propolis by in silico and in vitro studies in terms of possible covid-19 therapeutics
Güler, Halil İbrahim; Ay Şal, Fulya; Can, Zehra; Kara, Yakup; Yildiz, Oktay; Beldüz, Ali Osman; Çanakçi, Sabriye; Kolayli, Sevgi
Propolis is a multi-functional bee product rich in polyphenols. In this study, the inhibitory effect of Anatolian propolis against SARS-coronavirus-2 (SARS-CoV-2) was investigated in vitro and in silico. Raw and commercial propolis samples were used, and both samples were found to be rich in caffeic acid, p-coumaric acid, ferulic acid, t-cinnamic acid, hesperetin, chrysin, pinocembrin, and caffeic acid phenethyl ester (CAPE) at HPLC-UV analysis. Ethanolic propolis extracts (EPE) were used in the ELISA screening test against the spike S1 protein (SARS-CoV-2): ACE-2 interaction for in vitro study. The binding energy values of these polyphenols to the SARS-CoV-2 spike and ACE-2 protein were calculated separately with a molecular docking study using the AutoDock 4.2.6 program. In addition, the pharmacokinetics and drug-likeness properties of these eight polyphenols were calculated according to the SwissADME tool. The binding energy value of pinocembrin was highest in both receptors, followed by chrysin, CAPE, and hesperetin. Based on the in silico modeling and ADME (absorption, distribution, metabolism, and excretion) behaviors of the eight polyphenols, the compounds exhibited the potential ability to act effectively as novel drugs. The findings of both studies showed that propolis has a high inhibitory potential against the Covid-19 virus. However, further studies are now needed.
AtıfScopus35WoS29OpenAlex39İncele - MakaleYalnız künye2020Scopus SJRQ2Effects of processing methods and extraction solvents on the chemical content and bioactive properties of propolis
Ecem Bayram, Nesrin; Gerçek, Yusuf Can; Bayram, Sinan; Toğar, Başak
The aim of this study was to evaluate the bioactive properties of propolis extract prepared using different solvents and different extraction methods. The extracts were analyzed by gas chromatography–mass spectrometry (GC–MS) and the differences between their antibacterial activities were evaluated by disc diffusion method. At the same time, bioactive properties of different concentrations of propolis extracts were investigated on human umbilical vein endothelial cells (HUVEC). The proliferative effects and cytotoxic effects of the extracts were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) analyzes, respectively. Total antioxidant capacity (TAC) and total oxidative status (TOS) parameters were used in assessing biochemical effects in the HUVEC cell line. The DNA damage was also analyzed by 8-oxo-2-deoxyguanosine (8-OHdG) level as indicators of genotoxicity. As a result of the MTT analysis conducted within the scope of the present study, the extracts tested were sorted as 95% ethanol extract of propolis (PEE95) > ultrasonic ethanol extract of propolis (PUEE) > 50% ethanol extract of propolis (PEE50) > ultrasonic water extract of propolis (PUWE) in terms of the effectiveness of their cell viabilities. It was observed that high concentrations of PEE95 induced LDH release. In addition to this, our findings have shown that PEE50, PUEE and PUWE increased oxidative stress at high concentrations. According to 8-OH-dG analysis, all tested extracts were found to be non-genotoxic. The results obtained from antibacterial activity and minimum inhibition concentration tests showed that PUEE and PEE95 had stronger antibacterial effects than PEE50 and PUWE. All these results indicated that propolis has beneficial effects for human health and therefore it is a valuable product which can be used as a food supplement.
AtıfScopus23WoS22OpenAlex25İncele - MakaleYalnız künye2020Scopus SJRQ4Screening for antioxidant capacity, pollen types and phytochemical profile by GC/MS and UHPLC from propolis
Bayram, Nesrin Ecem; Gerçek, Yusuf Can; Öz, Gül Cevahir
Propolis is a resinous mixture collected by honeybees from different parts of plants such as poplars, birches, alders, conifers, pines, palms and willows. This study aims to determine pollen types (by light microscope), chemical compound profile (by GC-MS), fatty acid composition (by GC-MS), total phenolic content (by the Folin-Ciocalteu method), total flavonoid content (by the aluminium chloride method) and antioxidant capacity (by the CUPRAC, ABTS and CERAC methods) of a propolis sample from the western part of Istanbul, Turkey. As a result of microscopic analysis of the sample, pollen types of taxa belonging to 27 plant families were diagnosed. The GC-MS analysis of propolis revealed the presence of 38 phytochemical constituents that may contribute to its quality. Of these compounds, rates of "4H-1-benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy- 2-phenyl-,(S)"were highest. In addition, the concentrations of naringenin, pinocembrin and galangin were determined to be 2.45, 9.92 and 7.06 mg/ml by UHPLC analysis. The extract had significant antioxidant activity in all assays, with values of 282.8±9 mg TE /g in the CUPRAC, 425.7±18 mg TE/g in the CERAC and 186.4±8 mg TE/g in the ABTS assays. Antioxidant capacity of the propolis extract was positively associated with the total phenolic and flavonoid contents of the extract. Moreover, the major fatty acids were C20:1n9 (cis- 11-eicosenoic acid), C22:1 (erucic acid) and C24:1 (nervonic acid). The results show that the propolis used in our study has important potential as an alternative food supplement and for cosmetic and therapeutic medicine and it can be used as an active agent in these areas.
AtıfScopus20WoS18OpenAlex3İncele - MakaleYalnız künye2019Scopus SJRQ4Appropriate maceration duration for the extraction of propolis
Ecem-Bayram, Nesrin; Gercek, Ynsuf Can
The importance of the use of natural products as nutritional supplements in order to increase the quality of life and prevent diseases has increased in recent years. Among these products, propolis produced by honey bees is collected from plants and has a very complex structure in terms of chemical content. Propolis and its extracts have been used by humans for centuries because of its various bioactive properties. Although different methods can be used in the extraction stage, the most commonly used technique is extraction by maceration. However, there is no standard time period for extraction of propolis by maceration. We aimed to determine the changes in the concentrations of flavonoid group compounds pinocembrin, chrysin, tectochrysin, pi-nostrobin chalcone, gengwanin, naringenin and galangin from propolis samples exposed to seven different periods (1, 2, 5 10, 15, 20, 30 days) of maceration using GC-MS. The flavonoids pinocembrin, chrysin, tectochrysin, and naringenin reached their maximum concentrations at the end of 15 days of maceration and a decrease in their concentrations was observed after this period. The concentrations of other flavonoids did not show a steady increase or decrease with different maceration times. As a result, it can be said that the appropriate duration of maceration to extract the flavonoids responsible for propolis' numerous activities varies depending on the origin of the propolis and the nature of the compounds to be extracted.
AtıfScopus9İncele - MakaleYalnız künye2018Scopus SJRQ2Plant Origins of Propolis from Hakkari, Turkey
Ecem Bayram, Nesrin; Sorkun, Kadriye; Cevahir Oz, Gul
In this study, palynological analysis of 64 propolis samples from Hakkari province in Eastern Anatolia Region of Turkey was carried out. By microscopic analysis method, pollen diagnosis was made in propolis samples, and plants which may be propolis sources, were estimated. As a result, 71 plant taxa belonging to 34 families were identified at different rates in propolis samples. The pollens of the plants belonging to the family Apiaceae (2.7%-35%), Asteraceae (3.4%-35.4%) and, Fabaceae (12%-66%) were considerably found in the propolis of the Hakkari province. This study is the first report introducing the plant profile of Hakkari propolis in detail.
AtıfWoS1İncele - MakaleAçık Erişim2018Scopus SJRQ2Chemical characterization of 64 propolis samples from hakkari, Turkey
Bayram, Nesrin Ecem; Sorkun, Kadriye; Öz, Gül Cevahir; Salih, Bekir; Topçu, Gülaçtı
Propolis is a resinous substance produced by honey bees from various plants they visit. Sixty-four propolis samples were collected from different localities of four districts (Merkez, Yüksekova, Şemdinli, and Çukurca) in Hakkari territory. Ethanol extracts of the propolis samples were prepared, and their chemical contents were determined by gas chromatography–mass spectroscopy (GC–MS). Flavonoids were generally found in a high concentration in Şemdinli samples of Turkey. Twenty-seven coumarins were identified in the 28 propolis samples among studied 64 ones. Except suberosin, the coumarins were never reported before in any propolis sample with Turkish origin. The propolis samples belonging to Yüksekova were found to be richer in coumarins than the others, and the most richest one among the Yüksekova apiaries, was found to be Akocak sample (Y2) with 41.99% total yield, followed by Akçalı sample (Y5) (30.86%). This is a first comprehensive and original report about the chemical profile of propolis samples from Hakkari. The propolis samples from Hakkari exhibited a chemical content rich in flavonoids including coumarins and furocoumarins.
AtıfScopus16WoS14OpenAlex23İncele