Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Akmeşe, Osman(2)
- Aygül, İmdat(2)
- Baltacı, Cemalettin(2)
- Bayram, Sinan(2)
- Can, Zehra(2)
- Fidan, Muhammed Said(2)
- Keskin, Merve(2)
- Sefalı, Abdurrahman(2)
- Öz, Mehmet(2)
- AKMEŞE, Osman(1)
- AYGÜL, İmdat(1)
- BALTACI, Cemalettin(1)
- Balaydiin, Halis Türker(1)
- Basturk, Fatma Nur(1)
- Bayram, Nesrin Ecem(1)
- Beydemir, Şkrü(1)
- Birinci, Ceren(1)
- Boztaş, Kadir(1)
- Dagsuyu, Eda(1)
- Ekinci, Deniz(1)
- Esertaş, Ülkü Zeynep Üreyen(1)
- FIDAN, Muhammed Said(1)
- Gercek, Yusuf Can(1)
- Göksu, Sleyman(1)
- Kalkan, Seda Nur(1)
- Kara, Yakup(1)
- Karabulut, Ercan(1)
- Karlıdağ, Semiramis(1)
- Kaya, Gülşen(1)
- Keskin, Şaban(1)
- Kolaylı, Sevgi(1)
- Kostić, Aleksandar Ž.(1)
- Kurek-Górecka, Anna(1)
- Kırkıncı, Seran(1)
- Kıskanç, Gamze(1)
- Menzek, Abdullah(1)
- Olczyk, Paweł(1)
- Oz, Gül Cevahir(1)
- SEFALI, Abdurrahman(1)
- Soyut, Hakan(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ3Chemical Profiling of Stachys cretica subsp. anatolica Rech. f. (Endemic) Essential Oils and their Methanol Extracts with Evaluation as Enzyme Inhibitors, Antioxidant, and Antimicrobial Agents
Öz, Mehmet; Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman; Aygül, İmdat
Enzyme inhibition activities, phenolic compounds, antioxidant activities, bioactive compounds, antimicrobial activities, and chemical components of essential oil and methanol extracts obtained from the aerial parts of S. cretica subsp. anatolica were investigated. The main phenolic compounds of aerial parts were catechin, oleuropein, and epicatechin. The determined enzyme inhibitor activities highlight the potential of S. cretica subsp. anatolica as a source of bioactive compounds, particularly for carbonic anhydrase and cholinesterase inhibition. The essential oil and methanol extract exhibited remarkable activities against CA-II, AChE, and BChE, although they were less potent than standard inhibitors. The essential oils generally showed stronger antimicrobial activity compared to the 30% methanol extracts across most bacterial and fungal strains, as evidenced by minimum lethal concentration (MLC) and lower minimum inhibitory concentration (MIC) values and larger inhibition zones. Chloramphenicol used alone exhibited the highest antimicrobial efficacy, with the lowest MIC and MLC values and the largest inhibition zones. The essential oils of S. cretica subsp. anatolica were determined as esters, oxygenated sesquiterpenes, and aldehydes in aerial parts. The main components were found to be hexahydrofarnesyl acetone in the aerial parts.
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İncele - MakaleAçık Erişim2025Scopus SJRQ3Chemical composition of essential oils and comparative analysis of enzyme inhibitory, antioxidant and antimicrobial activities in essential oils of endemic Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N. Kilian
Fidan, Muhammed Said; Baltacı, Cemalettin; Akmeşe, Osman; Sefalı, Abdurrahman; Aygül, İmdat; Öz, Mehmet
In this study, essential oil from the aerial parts of Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N. Kilian was extracted via hydrodistillation using a Clevenger apparatus. GC-MS/FID analysis determined aldehydes (28.31%) as the dominant group, with eucalyptol (8.71%) as the main constituent. Antioxidant activities were exhibited using DPPH, ABTS, and FRAP assays, with the essential oil demonstrating relatively higher antioxidant properties. The essential oil also showed higher levels of bioactive components, including total antioxidant capacity (160.26 mg AA eq./100 mL), total phenolic content (21.57 mg GA eq./100 mL), and total flavonoid content (14.85 mg QE eq./100 mL). While G. sericea essential oil demonstrated some antioxidant activity, it was significantly lower compared to the reference standard ascorbic acid (AA). The antimicrobial results showed relatively higher antimicrobial activity compared to most bacterial and fungal strains, as evidenced by lower MIC and MBC values and larger inhibition zones. Nevertheless, chloramphenicol (CH) and nalidixic acid (NA) continually showed superior antimicrobial efficacy, with the lowest MIC and MBC values and the largest inhibition zones. The essential oil also demonstrated potent enzyme inhibitory activity, especially against CA-II, AChE, and BChE, with the lowest IC50 value observed for CA-II, highlighting its potential as a potent enzyme inhibitor. However, the essential oil exhibited comparatively greater inhibition against AChE, BChE and α-amylase but was less effective overall. These findings suggest that the G. sericea essential oil has important antioxidant potential and enzyme inhibitory activity, while the essential oil shows varying efficacy across different enzymes.
AtıfOpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2Enzyme inhibitory, antioxidant, antimicrobial activities, and phenolic profiles of the methanol extract of Gelasia sericea an endemic species
AYGÜL, İmdat; AKMEŞE, Osman; SEFALI, Abdurrahman; BALTACI, Cemalettin; ÖZ, Mehmet; FIDAN, Muhammed Said
This study aimed to investigate, for the first time, the phytochemical composition, antioxidant, antimicrobial, and enzyme inhibitory properties of the methanolic extract of Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N.Kilian. The extract demonstrated a moderate yield (6.55 g/100 g dry plant material) and was found to be rich in phenolic acids, particularly ferulic acid (17182.97 μg g-1), followed by caffeic acid, protocatechuic acid, and p-coumaric acid. Antioxidant analyses revealed high total phenolic (388.86 mg GA eq./100 g), total flavonoid (74.03 mg QE eq./100 g), and total antioxidant capacity (503.33 mg AA eq./100 g). The extract exhibited remarkable ABTS radical scavenging activity (95.99%, IC50 = 37.59 mg ml-1) and considerable ferric-ion reducing power (974.78 mg FeSO4 eq./100 g). Antimicrobial assays indicated moderate inhibitory effects, with stronger activity against Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis) and the yeast Candida albicans, whereas Gram-negative bacteria were less susceptible. The extract’s MIC values ranged between 0.20-3.25 mg ml-1, and MLC values between 0.41-6.50 mg ml-1, which were higher than those of standard antibiotics. Enzyme inhibition assays revealed moderate activity against carbonic anhydrase II (IC50 = 0.0136 µg ml-1) and weak inhibition of cholinesterases and α-glucosidase, while α-amylase inhibition was relatively more pronounced (IC50 = 13350.00 µg ml-1). Overall, these findings highlight G. sericea as a valuable natural source of phenolic acids and antioxidants, with promising potential for applications in functional foods, nutraceuticals, and phytopharmaceuticals. However, the relatively limited antimicrobial and enzyme inhibitory activities suggest the need for further studies on bioavailability, in vivo efficacy, and compound isolation to optimize its practical applications.
- MakaleYayıncıda açık erişim2024Scopus SJRQ1Enzyme Inhibitory, Physicochemical, and Phytochemical Properties and Botanical Sources of Honey, Bee Pollen, Bee Bread, and Propolis Obtained from the Same Apiary
Gercek, Yusuf Can; Dagsuyu, Eda; Basturk, Fatma Nur; Kırkıncı, Seran; Yıldırım, Nazlıcan; Kıskanç, Gamze; Özmener, Bahar; Unlu, Yigit Sabri; Kalkan, Seda Nur; Boztaş, Kadir
Bee products are an important source of nutrients and bioactive phytochemicals. This study aimed to determine the chemical composition (proximate composition, general phytochemical composition, sugar, and phenolic profiles) of four different products (honey, bee pollen, bee bread, and propolis), obtained from the same apiary, as well as to assess their biological activity through antioxidant and enzyme inhibition assays (α-amylase, α-glucosidase, lipase, AchE, neuraminidase, angiotensin-converting enzyme, urease, trypsin, tyrosinase, carbonic anhydrase, thioredoxin reductase, adenosine deaminase). Clear differences were observed among the samples in terms of both chemical composition and biological activity. The analysis revealed that bee pollen exhibited the highest carbohydrate content (87.9%), while propolis was identified as the richest source of phenolic compounds (14,858.9 mg/kg) among the analyzed samples. Propolis exhibited the highest biological activity in all applied antioxidant assays (CUPRAC, DPPH•, and ABTS•+) and in most enzyme inhibition assays. Notably, the α-glucosidase inhibition activity of propolis was comparable to that of the reference standard. In addition, honey exhibited remarkable trypsin inhibition, also comparable to the applied standard. These findings highlight the diverse bioactivities of hive products, which could play a key role in promoting health and preventing diseases.
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İncele - MakaleAçık Erişim2024Scopus SJRQ1Determination of phenolic content and bioactive characterization of Anatolian propolis
Can, Zehra; Birinci, Ceren; Kara, Yakup; Esertaş, Ülkü Zeynep Üreyen; Kolaylı, Sevgi
In this study, propolis referred to as of Türkiye Anatolian propolis was utilized. This work was aim to prepare a 70% ethanolic extract of propolis and subsequently determine certain biochemical parameters, total phenolic content (TPC), total flavonoid content (TFC), phenolic and flavonoid composition, inhibitory effects on certain enzymes [acetylcholinesterase (AChE), urease, and alpha-amylase], along with assessments of antiviral activity against Vero cells, lung cancer cells (A549), and breast cancer cells (MDA-MB-231). The richness of phenolic content in Anatolian propolis clearly indicates a high inhibitory effect on these enzymes. Additionally, it was observed to exert significant effects on cancer cells and demonstrated effective antiviral activity. It can be contemplated that the Anatolian propolis might serve as a potential source for novel drugs, and the isolation of its compounds could offer opportunities for utilization in traditional medicine.
AtıfScopus9WoS10OpenAlex11İncele - MakaleAçık Erişim2023Scopus SJRQ1Palynological, chemical, antimicrobial, and enzyme inhibition properties of Cannabis sativa L. propolis
Özkök, Aslı; Karlıdağ, Semiramis; Keskin, Merve; Bayram, Sinan; Keskin, Şaban; Karabulut, Ercan; Çiçek, Fevzi; Yılmaz, İsmet
In this study, both chemical characterization and biological activities of propolis samples obtained from Cannabis sativa L. (cannabis, hemp, marijuana) isolated colonies (research group) and obtained from colonies at a distance where the bee cannot fly to the isolation area (control group) were determined. Palynological analyses of propolis samples obtained from the research and control group colonies were made and the botanical origin of the cannabis plant and other plants in the research area and the plants in the control group were determined. Bioactive component analysis of propolis extracts was determined by the GC–MS technique. The inhibition effect of propolis samples on some enzymes of medical importance and their antimicrobial effects against many pathogenic microorganisms were also investigated. Palynological analyses showed that honey bees prefer cannabis plants (11.11%) when collecting propolis, and the dry matter percentage (94.6 ± 1.8%), balsam (46.2 ± 5.2%), and wax content (4.8 ± 0.5%), total phenolic (26.44 ± 1.08 mg GAE/mL) and total flavonoid (2.03 ± 0.11 mg QE/mL) content and antioxidant capacity (88.16 ± 2.27 μM FeSO4·7H2O/mL−1) of the research group propolis samples containing hemp were found to be higher than the control group. Also, it was determined that the research group propolis sample contains cannabinoid derivatives (cannabidivarinic acid, 0.29%; delta (1)-tetrahydrocannabinolic acid, 0.59%; cannabidiolic acid, 0.48%), which are active compounds of the cannabis plant. Also, a high inhibition effect was detected on some enzymes of medical importance in propolis samples obtained from cannabis group colonies. In addition, the research group propolis samples also showed a high antimicrobial effect against many pathogenic microorganisms.
AtıfScopus5WoS5OpenAlex4İncele - MakaleAçık Erişim2023Scopus SJRQ1Green Synthesis, Characterization, Antioxidant, Antibacterial and Enzyme Inhibition Effects of Chestnut (Castanea sativa) Honey-Mediated Silver Nanoparticles
Keskin, Merve; Kaya, Gülşen; Bayram, Sinan; Kurek-Górecka, Anna; Olczyk, Paweł
In this study, chestnut honey-based silver nanoparticles (CH-AgNPs) were synthesized at different temperatures (30, 60 and 90 °C) and these nanoparticles were characterized by different techniques such as UV–vis spectrophotometer, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX). The DPPH free radical scavenging assay was used to determine the antioxidant activity of the obtained nanoparticles. The inhibition effects of these nanoparticles for some clinically important enzymes such as myeloperoxidase and collagenase were investigated. In addition, the disk diffusion method (DDM), agar well diffusion (AWD), and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) techniques were used to determine the antibacterial activity of CH-AgNPs. In honey-based silver nanoparticle production processes using green synthesis, it was determined that the nanoparticle sizes decreased from 55 to 27 nm with an increase in temperature. In addition, it was determined that the rate of inhibition of myeloperoxidase (36.4% to 34.0%) and collagenase enzymes (74.2% to 68.7%) increased with a decrease in particle size. As a result of the antibacterial activity tests, it was observed that CH-AgNPs have antibacterial activity against all target pathogens including Gram-positive and Gram-negative bacteria. The obtained results show that CH-AgNPs produced using chestnut honey have the potential to be used in fields such as medicine, pharmacy and cosmetic technology.
AtıfScopus48WoS41OpenAlex42İncele - MakaleYalnız künye2018Scopus SJRQ3Determination of in-vitro antioxidant, anti-urease, anti-hyaluronidase activities by phenolic rich bee products from different region of Turkey
Can, Zehra
In this study, enzyme inhibition of urease and hyaluronidase are clinically important functions were examined by different authenticity bee products. Different floral honey, pollen and propolis samples were analyzed in terms of total phenolic compounds (TPC), total flavonoid contents (TFC), ferric reducing antioxidant capacity (FRAP), cupric reducing antioxidant capacity (CUPRAC), and 2,2-diphenyl-1-picryhydrazyl (DPPH) free radical scavenging activities as antioxidant determinants. For the determination of the phenolic composition of the products, RP-UV-HPLC was used. TPC of the honey, pollen and propolis samples were ranged from 17 to 95 and 770 to 989 mg of gallic acid (GAE)/100g, 135-258 mg of GAE/g, and TFC was 1 to 10 mgQE/100g, and 78 to 99 mgQE/100 g, and 9 to 10 mg of QE/g, respectively. Among the bee products, propolis samples were showed the highest phenolic componds, that contained different quantity of protocatequic acid, catechin, caffeic acid, p-coumaric acid, p-hydroxybenzoic acid, ferulic acid and rutin. The urease inhibition vales (IC50) were changed from 7.02 to 33.25 mg/mL, 5.00 to 8.78 and 0.16 to 1.98 mg/mL in the honey, pollen and propolis samples, respectively. The hyaluronidase inhibition values (IC50) were changed from 0.02 to 0.46 g/mL, 0.02 to 0.26 g/mL and 3.26 to 9.21 μg/mL in the honey, pollen and propolis samples, respectively. Honey, pollen and propolis have a significant inhibition on the enzymes, the inhibition may be due to secondary metabolites of phenolic compounds and the mechanism of the inhibition should be studied in detailed.
AtıfScopus8İncele - MakaleAçık Erişim2012Scopus SJRQ2Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products
Balaydiin, Halis Türker; Soyut, Hakan; Ekinci, Deniz; Göksu, Sleyman; Beydemir, Şkrü; Menzek, Abdullah; Şahin, Ertan
(2-Bromo-3,4-dimethoxyphenyl) (3,4-dimethoxyphenyl)methanone (10) and its derivatives with Br, one dibromide and isomeric three tribromides, were synthesized. Demethylation of these compounds afforded a series of new bromophenols. Inhibition of human cytosolic carbonic anhydrase II (hCA II) isozyme by these new bromophenols and naturally occurring 3,4,6-tribromo-5-(2,5- dibromo-3,4-dihydroxybenzyl)benzene-1,2-diol (3), and 5,5′-methylenebis(3, 4,6-tribromo-benzene-1,2-diol) (4) was investigated. The synthesized compounds showed carbonic anhydrase inhibitory capacities with IC 50 values in the range of 0.7372 μM against hCA II. Some bromophenols investigated here showed effective hCA II inhibitory activity and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, or osteoporosis.
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