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- MakaleAçık Erişim2025Scopus SJRQ1Investigation of endocrine and cerebral response and nutrition and physical performance parameters according to bigorexia nervosa levels: a cross-sectional study in sports sciences faculty students
Erkılıç, Ali Ozan; Bayraktar, Bülent; Erkiliç, Tuğçe Orkun; Türkmen, Mutlu; Kul, Murat; Yönal, Mehmet
The aim of this study is to investigate the effects of Bigorexia nervosa (BGN) levels on endocrine (Asprosin, GLP-1) and cerebral (BDNF) responses and nutritional and physical (6MWT, Six-Minute Walk Test)), speed, metabolic equivalent unit (MET)) performance parameters in students of the faculty of sports sciences. This study investigated muscle dysmorphic disorder (MDD), physical activity levels, and specific hormonal markers in 120 university students (63 females, 57 males) aged 18–25 years, all studying sport sciences and reporting no existing health problems. Participants completed a demographic questionnaire, food frequency questionnaire and the Muscle Dysmorphic Disorder (Bigorexia) Inventory through face-to-face interviews. Physical activity was assessed using the 6-Minute Walk Test (6MWT) to measure walking distance, and Metabolic Equivalent (MET) was calculated based on the American College of Sports Medicine (ACSM) formula. Body Mass Index (BMI) was determined from anthropometric measurements of height and body weight. Saliva samples were collected to analyze Asprosin, BDNF, and GLP-1 hormone levels using the ELISA technique.Data were analyzed using number, percentage, mean, chi-square, t-test, Pearson correlation, and ANOVA tests. In all analyses, significance was accepted as p < 0.05. According to the demographic findings of the study, the majority of participants (64.2%) were third-year students, and 52.5% were female. The mean age of the participants was 22.01 years, the mean height was 168.59 cm, and the mean weight was 62.61 kg. 73.3% of the individuals were classified as normal weight, 12.5% as pre-obese, 11.7% as underweight, and 2.5% as obese. Men had significantly higher bigorexia and its subscale scores than women (p < 0.05), and bigorexia was positively correlated with height and negatively correlated with BMI (p < 0.01). Mean salivary BDNF levels were higher in participants consuming 1–2 meals per day (p = 0.035), and mean salivary asprosin levels were significantly higher in the obese group compared to the healthy group (p = 0.008). Additionally, a strong positive correlation was found between asprosin and GLP1 levels (r = 0.585; p < 0.01). Bigorexia status was significantly associated with meat, meat products, and fat consumption (p < 0.05), while no association was found with physical performance parameters such as 6MWT, speed, and MET (p > 0.05). The average MET value was found to be 4.53, indicating that participants generally engaged in moderate-intensity physical activity. In conclusion, examining endocrine (asprosin, GLP-1) and cerebral (BDNF) hormone responses, as well as nutritional and physical performance parameters, according to BGN levels reveals the impact of BGN on physiological and nutritional behaviors. Given the impact of BGN trends on students’ health, examining hormone profiles and their relationships with physical performance and nutrition is believed to significantly contribute to understanding the health problems associated with BGN and developing appropriate interventions.
- MakaleAçık Erişim2024Scopus SJRQ2Eugenol alleviates the negative effects of experimental periodontitis and regulates adipokine hormones in rats
Sevinç Gül, Sema Nur; Özkal Eminoğlu, Didem; Tekçe, Emre; Bayraktar, Bülent; Güven, Leyla; Dilsiz, Alparslan; Yıldırım, Serkan; Sait, Ahmet
A chronic microbial infection that is mediated by the host's immune system is the cause of periodontal disease. As the world's population grows, phytotherapy is a therapeutic strategy that makes use of a renewable resource that can provide less costly medicines. This study aimed to investigate the therapeutic effects of eugenol administration on periodontitis by examining the effects of eugenol at different doses biochemically, histopathologically, and radiologically in rats with experimental periodontitis. Thirty-two Sprague Dawley male rats were divided into four groups: 1. the healthy control group (CG), 2. The experimental periodontitis group (PG), 3. The experimental periodontitis+10 mg/kg eugenol group (EG10), and 4. the experimental periodontitis+20 mg/kg eugenol group (EG20). Alveolar bone loss was measured using micro-CT imaging. The TNF-α, IL-6, leptin, asprosin, and apelin levels were analyzed in the serum samples of rats. Histological and immunohistochemical analyses were performed. The data were analyzed statistically. The serum TNF-α, IL-6, leptin, asprosin, and apelin levels were found to be statistically significantly lower in the eugenol-applied groups (EG10 and EG20) than in the PG (p < 0.05). There was a statistically significant difference in the TNF-α, IL-6, leptin, asprosin, and apelin levels between the EG10 and EG20 (p < 0.05). In the measurements made using micro-CT imaging, alveolar bone loss was found to be at the lowest FR1 level, and in histopathological analysis, the least inflammation was observed in the EG20. It was concluded that the application of 20 mg/kg eugenol in rats with experimental periodontitis was a safe dose, was beneficial in alleviating bone loss, and had a positive effect on the healing process.
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İncele - MakaleAçık Erişim2021Scopus SJRQ4Investigation of the relationship of asprosin and cardiac troponin response with some physiological and biochemical parameters in Anatolian native horse
Bayraktar, Bülent; Tekce, Emre
Summary: Asprosin is a recently discovered glucogenic hormone released from starvation-induced white adipose tissue and amongst others it protects against hyperinsulinism associated with metabolic syndrome. The aim of this study was to examine the effect of age, gender and season on metabolic (asprosin) and cardiovascular (cardiac troponin, I (cTnI), CK, CK-MB) function markers and their relationship with some biochemical parameters in Anatolian native horse breed. This study was carried out between February–August 2020. A total of 40 horses was used for this purpose, including 20 mares and 20 stallions in the age range of 1–6, 7–12. Serum asprosin level, for the winter season in stallions and mares aged 1–6 and 7–12 years respectively 8.9, 8.36; 14.08, 13.58ng/ml were as determined. In addition, for the summer season respectively 17.98, 18.68; 22.22, 21.32ng/ml were detected and no difference between the groups (P>0.05). On the other hand, serum cTnI levels for the winter season in stallions and mares aged 1–6 and 7–12 years respectively 0.014, 0.018; 0.016, 0.02ng/ml were as determined. In addition, for the summer season respectively 0.012, 0.016; 0.014, 0.018ng/ml were detected. It was shown that the serum biochemical parameters and levels of cTnI levels in the domestic horse breed the horses belonging to the Anatolian varied depending on age, gender, and season (p < 0.05) but the effect of hormone levels serum asprosin wasn’t found statistically significant (p>0.05).Our results showed that cTnI could be a useful parameter in the examination of the cardiovascular system status of horses.
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