Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Alp, Hakan(2)
- Başoǧlu, Aysel(2)
- Kantekin, Halit(2)
- Ocak, Ümmühan(2)
- Ozturk, K.(2)
- Parlayan, Semanur(2)
- Yanmaz, E.(2)
- Abdioglu, M.(1)
- Adal, Samiye(1)
- Akaras, Nurhan(1)
- Akin, Ozlem(1)
- Bolat, S.(1)
- Demir, I.(1)
- Duran, Celal(1)
- Duz, I.(1)
- Efeoglu, Hasan(1)
- Erdem, O.(1)
- Eroglu, Salih(1)
- Gencer, A.(1)
- Guner, S. B.(1)
- Hossain, S.(1)
- Imamoglu, Ilyas Kays(1)
- Isik, Cem(1)
- Jeevarathinam, G.(1)
- Kandemir, Fatih Mehmet(1)
- Kapucu, V.(1)
- Karabacak, Azime Ozkan(1)
- Kizil, Hamit Emre(1)
- Korkmaz, Sadan(1)
- Koç, Gulsah Caliskan(1)
- Kutuk, S.(1)
- Küçükler, Sefa(1)
- Malçok, Senanur Durgut(1)
- Mutlu, Huseyin(1)
- Ocak, M.(1)
- Ocak, Miraç(1)
- Ongan, Serdar(1)
- Ozdes, Duygu(1)
- Pandiselvam, Ravi(1)
- Pat, Suat(1)
Yayınlar
- MakaleYalnız künye2026Scopus SJRQ1Morin counteracts KBrO3-induced hepatotoxicity by reprogramming the HOTAIR/MEG3-miR-125b-5p/miR-214-5p axis and suppressing STAT1-associated RIPK3/MLKL necroptotic signaling
Özer, Muhammed Rasit; Özdemir, Selcuk; Küçükler, Sefa; Özkaraca, Mustafa; Kizil, Hamit Emre; Akaras, Nurhan; Mutlu, Huseyin; Kandemir, Fatih Mehmet
Potassium bromate (KBrO3; PB), an oxidative contaminant in ozonated water and bakery products, induces multi-mechanistic hepatotoxicity. Its epigenetic, necroptotic, and metabolic injury dimensions remain poorly characterized. Morin (MOR), a dietary flavonoid with established antioxidant and anti-inflammatory properties, has not previously been evaluated against PB-induced subacute hepatotoxicity. To characterize MOR's hepatoprotective mechanisms against PB-induced liver injury, focusing on the HOTAIR/MEG3-miRNA epigenetic axis, STAT1-associated RIPK3/MLKL necroptotic signaling, and Glut2/HPGD-AKT/mTOR metabolic signaling. Male Sprague-Dawley rats (n = 28) were assigned to Control, MOR (100 mg/kg), PB (62 mg/kg), and PB + MOR groups for 14 days. Outcomes included hepatobiliary biochemistry, oxidative stress markers, inflammatory mediators (ELISA), lncRNA/miRNA/mRNA profiling (RT-qPCR), immunohistochemistry (RIPK3, MLKL), double immunofluorescence (Glut2/AKT1; HPGD/mTOR), histopathology, and PCA. PB produced marked redox imbalance (up arrow MDA; down arrow SOD, CAT, GPx), NF-kappa B/NLRP3-associated inflammatory mediator elevation, epigenetic disruption (up arrow HOTAIR, down arrow MEG3; up arrow miR-125b-5p/down arrow BCL2L2; down arrow miR-214-5p/up arrow SMAD4), upregulation of STAT1-associated necroptosis-related transcripts and proteins (up arrow RIPK1/RIPK3/MLKL), and metabolic dysfunction (down arrow Glut2, down arrow HPGD; up arrow AKT1/mTOR). MOR restored redox balance, suppressed inflammation, and reprogrammed the miRNA axis while normalizing MLKL (transcript and immunohistochemistry) and AKT1 and partially attenuating RIPK3, mTOR, and STAT1. MOR confers multi-targeted hepatoprotection by restoring redox and metabolic homeostasis, attenuating NF-kappa B/NLRP3-associated inflammation, reprogramming HOTAIR/MEG3-miRNA epigenetics, and attenuating STAT1-associated RIPK3/MLKL signaling, supporting its potential as a dietary hepatoprotective candidate. PB is associated with engagement of the hepatic STAT1/RIPK3/MLKL axis and disrupts the HOTAIR/MEG3-miRNA network-both previously undocumented for this toxicant. MOR partially restores miR-214-5p/miR-466 expression while suppressing their downstream effector SMAD4, consistent with attenuation of pro-fibrotic signaling. Future work should employ multi-dose designs, in vitro mechanistic dissection, sex-stratified analyses, and clinical pharmacokinetic profiling to advance MOR toward translational application.
- MakaleYalnız künye2026Scopus SJRQ2The moderating effects of geopolitical risks on sustainable development through economic complexity and renewable energy consumption in 25 oil-producing countries
Ongan, Serdar; Özdemir, Dilek; Imamoglu, Ilyas Kays; Isik, Cem
Conflicts in controlling or using natural resources, arising from geopolitical risks (GPR), which have become a new normal today, can damage natural ecosystems and threaten sustainable development. In this context, GPR can turn the positive impact of supporting independent variables on sustainable development (SD) into a negative one. This research investigates the moderating effects of GPR on SD through renewable energy consumption (REN) and economic complexity (EC) in 25 oil-producing countries with relatively higher oil-reserve-related risks between 2000 and 2021. The panel quantile regression analysis reveals. (i) While using REN individually improves SD in countries with high SD (in the 80th and 90th quantiles), this improving effect turns to a worsening effect due to its interaction with GPR, which shows the moderating impact of GPR. (ii): While EC individually improves SD across all quantiles, these improving effects persist in countries with low SD (in the 10th, 20th, 30th, and 40th quantiles) even when complexity interacts with GPR, showing that GPR has no moderating impact on SD. Therefore, policymakers should investigate why the interaction of REN with GPR worsens SD in highly sustainable countries and redevelop regulatory renewable energy policies accordingly.
- MakaleAçık Erişim2025Scopus SJRQ2Investigation of the memristive properties of the device form and thin film form of BST and CeO2 films with different arrays
Akin, Ozlem; Efeoglu, Hasan
In this study, a memristor structure known as a missing circuit element was produced. This study consists of a total of six samples in both thin film and device form with different arrays of BST film and CeO2 film on SiO2/Si substrate. The effects of different arrays and device forms of these two films on memristive behavior were investigated. It was observed that the structures exhibited memristive behavior due to the difference in ion mobility in films with different dielectric constants. It was also observed that the structures changed their memristive behavior in the annealing process performed at different temperatures. It was observed that the memristive behaviors examined imitated the connection strength of artificial synapses, and they are suitable for the production of multi-bit memristors or analog memristors suitable for the creation of artificial neuromorphic networks.
- Derleme MakaleAçık Erişim2025Scopus SJRQ1Evaluation of the Effect of Sustainable Drying Techniques and Intensification Technologies on Color Profile of Dehydrated Fruits and Vegetables
Süfer, Ozge; Koç, Gulsah Caliskan; Öztekin, Sebahat; Karabacak, Azime Ozkan; Su, Dianbin; Wang, Deqing; Eroglu, Salih; Malçok, Senanur Durgut; Uslu, Ulku Hilal; Adal, Samiye
This research investigates the effects of various drying procedures and intensification technologies on the color profile of dried fruits and vegetables. The primary goal is to identify the most effective techniques for minimizing degradation, which is frequently caused by exposure to heat, oxygen, and longer drying durations, while retaining the original color of these products. Although conventional techniques like sun and hot air drying are often employed, enzymatic and non-enzymatic brownings usually cause a considerable loss of color. New technologies aim to better preserve the original color by cutting down on processing temperature and drying time. The paper also looks at the possibilities of hybrid drying approaches, which combine techniques such as infrared hot air drying and microwave hot air drying. These methods have been demonstrated to be especially successful in preserving color integrity and enhancing drying process effectiveness. The results highlight the vital significance that parameter optimization and drying technique selection play in maintaining the nutritional value and aesthetic appeal of dehydrated fruits and vegetables. This study emphasizes the significance of developing drying technologies to satisfy consumer desires for premium, aesthetically pleasing food goods, because color is a major factor in determining consumer acceptance and perceived product quality. With wider implications for food preservation and the food industry overall, this work helps to develop more effective and efficient drying processes by shedding light on how various drying techniques affect color retention.
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İncele - MakaleAçık Erişim2016Scopus SJRQ2Surface, Nanomechanical, and Optical Properties of Mo-Doped GeGaAs Thin Film Deposited by Thermionic Vacuum Arc
Pat, Suat; Senay, Volkan; Özen, Soner; Korkmaz, Sadan
Mo-doped and undoped GeGaAs layers have been deposited by the thermionic vacuum arc (TVA) method, an alternative, fast plasma deposition technique. The thicknesses of the deposited layers were identical. The surface, mechanical, and optical properties of the deposited layers were studied to determine the influence of Mo doping on GeGaAs. The transparency of GeGaAs was shifted towards the near-infrared region by Mo doping. Bandgap values shifted by approximately 0.3 eV. In other words, the bandgap value of Mo-doped GeGaAs was nearly equal to that of GaAs materials. The average roughness and grain size of the Mo-doped material were smaller than for the GeGaAs layer. The particle distributions of the Mo-doped and undoped GeGaAs were almost perfect Gaussians. However, the mean height of the Mo-doped GeGaAs grains was six times that for undoped GeGaAs. The surface was homogeneous. The Mo-doped layer showed greater absorbance than the GeGaAs material. The produced Mo-doped sample showed hybrid properties.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2014Scopus SJRQ3Comparison of Levitation Forces of Bulk MgB2 Superconductors Produced by Nano Boron and Carbon-Doped Nano Boron
Duz, I.; Guner, S. B.; Erdem, O.; Demir, I.; Kapucu, V.; Çelik, S.; Ozturk, K.; Hossain, S.; Gencer, A.; Yanmaz, E.
MgB2 bulk superconductors were prepared by hot press plus furnace heating method. Two types of boron powders were used, one is amorphous nano boron and the other is C-doped boron. Characteristics of superconductors were determined by XRD and resistance measurements. Systematic levitation force measurements were performed by using a modular system at low temperatures. These bulk superconductors showed around 9 N repulsive and 4 N attractive forces in the z-axis at 20 K at closest point to the cryostat lid which contains the MgB2 superconductor. These values slightly decreased by increasing temperature to 24 and 28 K for both samples. Comparing two samples, nano boron MgB2 showed slightly higher levitation force than C-doped MgB2 although C-doped MgB2 has higher attractive force value at the closest point. This situation points out that C-doped MgB2 is much proper for attractive force applications (as guidance force) while the nanoboron MgB2 sample is much appropriate for repulsive force (as levitation).
AtıfScopus13WoS13OpenAlex17İncele - MakaleAçık Erişim2013Scopus SJRQ2Biosorption properties of Morus alba L. for Cd (II) ions removal from aqueous solutions
Serencam, Huseyin; Ozdes, Duygu; Duran, Celal; Tufekci, Mehmet
The abundantly available industrial waste product Morus alba L. pomace (MAP) is one of the cost-effective biosorbent for removal of metal ions from aqueous solutions. Hence, in the present study, we aimed to test the ability of MAP to remove Cd(II) ions through batch biosorption process. Firstly, MAP was characterized using several techniques, and then the influence of various experimental parameters such as initial pH of the aqueous solution, initial Cd(II) concentration, contact time, MAP concentration, and temperature were evaluated upon the biosorption process. It was found that the maximum uptake of Cd(II) ions occurred at initial pH 6.0 and optimum contact time was observed as 60 min. Cd(II) ions adsorption on MAP analyzed by the Langmuir and Freundlich isotherm models and the maximum monolayer biosorption capacity of MAP was found to be 21.69 mg g-1 by using the Langmuir isotherm model. The pseudo-first-order, pseudo-second-order, Elovich, and intraparticle diffusion models were employed to describe the biosorption kinetics. In order to investigate the thermodynamic properties of the biosorption process, the changes in the Gibbs free energy (â̂†G), enthalpy (â̂†H), and entropy (â̂†S) were also evaluated and it has been concluded that the process was feasible, spontaneous, and endothermic in the temperature range of 5-40 C.
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İncele - MakaleYalnız künye2012Scopus SJRQ3Effect of magnetic flux distribution and magnetic powder addition on the magnetic levitation force of Sm123 superconductors
Abdioglu, M.; Ozturk, K.; Kutuk, S.; Bolat, S.; Yanmaz, E.
Sm123 and Sm211 were prepared by melt-powder-melt-growth and solid-state-reaction techniques, respectively, to have the nominal composition of (Sm123) 0.75 (Sm211) 0.25. After the preparation of this composition, the Fe-B magnetic powder (MP) was added to the composition for 0.000, 0.010, 0.015, 0.025, 0.050 wt.% to investigate the effect of MP addition on the levitation force density (LFD). Additionally, different permanent magnets (PM) were used as magnetic-field source to investigate the effect of magnetic-field gradient on the LFD of MP added superconductors. Our findings indicate that the MP addition acts as a flux pinning centre in the sample and enhances the LFD up to 0.025 wt.% adding amount, and the optimum flux gradient which produces a screening current in the sample occurs when the B/d (magnetic-field intensity/ diameter of PM) ratio is equal to 0.060. These results imply that the experimental data can be useful for fabricating process of superconducting samples with larger MLF values, and designing of superconducting magnets, flywheel energy storage and maglev systems.
AtıfScopus10WoS10OpenAlex10İncele - MakaleAçık Erişim2010Scopus SJRQ2Complexation of metal ions with the novel diazadithia crown ethers carrying two pyrene pendants in acetonitrile-tetrahydrofuran
Ocak, Ümmühan; Ocak, Miraç; Başoǧlu, Aysel; Parlayan, Semanur; Alp, Hakan; Kantekin, Halit
Two crown ethers carrying pyrene side arms with nitrogen-sulfur donor atom were designed and synthesized by the reaction of the corresponding macrocyclic compounds and 1-bromomethyl-pyrene. The influence of metal cations such as Al3+, Zn2+, Fe2+, Fe3+, Co2+, Ni2+, Mn2+, Cu2+, Cd2+, Hg2+ and Pb2+ on the spectroscopic properties of the ligands was investigated in acetonitrile-tetrahydrofuran (1:1) by means of absorption and emission spectrometry. Absorption spectra show isosbestic points in the spectrophotometric titration of Al3+, Zn2+, Fe2+, Ni2+, Cu2+, and Pb2+ with 16-membered crown ether. Similar results were obtained for Al3+, Fe2+, Hg2+, Cu2+ and Pb2+ with 14-membered crown ether. The results of spectrophotometric titration experiments disclosed the complexation stoichiometry and complex stability constants of the novel ligands with these cations. According to spectrofluorimetric titration measurements the 14-membered diazadithia crown ether showed sensitivity for Pb2+ with linear range and detection limit of 1.3 × 10-6 to 5.2 × 10-5 M and 5.2 × 10-7 M, respectively. The 16-membered diazadithia crown ether showed sensitivity for Ni2+ with linear range and detection limit of 1.3 × 10-7 to 5.2 × 10-6 M and 4.1 × 10-8 M, respectively.
AtıfScopus9WoS8OpenAlex8İncele - MakaleYalnız künye2010Scopus SJRQ1Photodimerizations of hydroxy- and benzoylated 4-azachalcones and quantum chemical investigation of the reactions
Yaşar, Ahmet; YaylI, Nuran; Usta, Asu; YaylI, Nurettin
Photodimerization reactions of compounds 4-6 gave four new cyclobutane-containing compounds (7-9) with full control over the stereochemistry at the four stereogenic centers. These new cyclobutane- containing compounds had β-truxinic (7a), δ-truxinic (7b and 9), and ε-truxillic (8) structures. However, o-, m-, and p-hydroxy 4-azachalcones (1-3) did not give photochemical cyclization products under any conditions (in solvent or in their solid or molten states). Experimental data suggested the possibility of frontier orbital control over stereochemical behavior, so some theoretical calculations were performed. Full geometrical optimization of compounds 1-9 was performed via DFT B3LYP/6-31+G**, and their electronic structures were also investigated. The geometries of the singlet and triplet states were initially optimized by density functional theory (DFT) and the configuration interaction singles (CIS) B3LYP/3-21 +G**level. An additional calculation was performed for the triplet state using the ground-state geometry. The possible photochemical dimerization products of compounds 7-9 (a-g) and the intrinsic reaction coordinates (IRCs) of the reactions of compounds 4-6 were calculated theoretically by the DFT/3-21+G**method. The configurations (reactant, transition state, product, and reaction pathway) corresponding to the stationary points (minima or saddle points) were determined. The intrinsic reaction coordinates were followed to verify the energy profiles that connect each TS to the appropriate local minimum. The dimeric products expected from the calculations coincided with the dimers produced experimentally.
AtıfScopus4WoS3OpenAlex2İncele - MakaleYalnız künye2010Scopus SJRQ2Complexation of metal ions with the novel diazadithia crown ether carrying two anthryl pendants in acetonitrile-tetrahydrofuran
Parlayan, Semanur; Başoǧlu, Aysel; Ocak, M.; Alp, Hakan; Kantekin, Halit; Ocak, Ümmühan
A new crown ether carrying two anthryl groups with nitrogen-sulfur donor atom was designed and synthesized by the reaction of the corresponding macrocyclic compound and 9-chloromethyl anthracene. The influence of metal cations such as Al3+, Zn2+, Fe2+, Fe3+, Co2+, Ni2+, Mn2+, Cu2+, Cd2+, Hg2+ and Pb2+ on the spectroscopic properties of the ligand was investigated in acetonitrile-tetrahydofuran solution (1/1) by means of absorption and emission spectrometry. Absorption spectra show isosbestic points in the spectrophotometric titration of Fe2+, Fe3+, Al3+, Cu2+ and Hg2+. The results of spectrophotometric titration experiments disclosed the complexation stoichiometry and complex stability constant of the novel ligand with Fe2+, Fe3+, Al3+, Cu2+and Hg2+cations. The presence of excess amounts of Al3+, Zn2+, Fe2+, Fe3+, Co2+, Ni2+, Mn2+, Cu2+, Cd2+, Hg2+ and Pb2+ cations caused an enhancement of anthryl fluorescence. The ligand showed good sensitivity for Zn2+ with respect to other metal cations with linear range and detection limit of 1. 4 × 10-7 to 4. 1 × 10-6 M and 1. 0 × 10-8 M respectively.
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