Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Alaylar, Burak(2)
- Güllüce, Medine(2)
- Karabulut, Abdulhalik(2)
- Sakar, Erdem(2)
- Abu Al-Sayyed, Ibrahim(1)
- Abu Al-Sayyed, Mohammed Ibrahim(1)
- Aklncloǧlu, Akln(1)
- Aksu, Seyma(1)
- Alim, Bunyamin(1)
- Allm, Bünyamin(1)
- Aygün, Bunyamin(1)
- Aygün, Bünyamin(1)
- Göksu, Süleyman(1)
- Karadayi, Mehmet(1)
- Karadayl, Mehmet(1)
- Kocaman, Ebu Talip(1)
- Pelit, Emel(1)
- Turgut, Zuhal(1)
- Turhan, Kadir(1)
- Özpolat, Özgür Flrat(1)
Yayınlar
- MakaleAçık Erişim2021Scopus SJRQ3Determination of radioprotective and genotoxic properties of sulfamide derivatives
Aygün, Bünyamin; Alaylar, Burak; Aklncloǧlu, Akln; Allm, Bünyamin; Kocaman, Ebu Talip; Karadayl, Mehmet; Abu Al-Sayyed, Mohammed Ibrahim; Aksu, Seyma; Sakar, Erdem; Özpolat, Özgür Flrat
Some potential drug active substances with the ability to reduce the effects of radiation on human tissues and cells were investigated. For this purpose, eight different types of sulfamide derivatives were synthesized and nuclear radiation protection parameters were determined. Neutron radiation reduction parameters such as the half-value layer effective removal cross-sections, mean free path, and the number of particles passing through the sample were determined with GEANT4 code. Additionally, the gamma radiation attenuation parameters of the materials examined were determined using Phy-X/PSD software in the energy area of 0.015-15 MeV. These parameters are the half-value layer, mass attenuation coefficient, mean free path, exposure buildup factor and effective atomic number. Neutron radiation absorption experiments were applied using an 241Am-Be fast neutron source. All results obtained for neutron radiation were compared with paraffin and water. It has been found that the ability of sulfamide derivatives to absorb these radiations is superior to reference materials. To determine whether these derivatives could have adverse effects on human health, their genotoxic potential was determined using the Ames/Salmonella bacterial reversion test. The results showed that these derivatives can be considered genotoxically safe in tests at concentrations up to 5 mM. Thus, it is suggested that the derivative materials examined in this study can be used as active substances for a drug to be made for protection against both neutron and gamma radiation.
AtıfScopus10WoS9OpenAlex11
İncele - MakaleAçık Erişim2020Scopus SJRQ2Investigation of neutron and gamma radiation protective characteristics of synthesized quinoline derivatives
Aygün, Bunyamin; Alaylar, Burak; Turhan, Kadir; Sakar, Erdem; Karadayi, Mehmet; Abu Al-Sayyed, Ibrahim; Pelit, Emel; Güllüce, Medine; Karabulut, Abdulhalik; Turgut, Zuhal
Purpose: Quinoline is formed by various natural compounds, such as alkaloids from the cinchona plant, which exhibit various biological activities, and is an important building material for the development of new drugs. Quinoline can be used in anti-radiation drug development but radiation interaction properties must be determined. Material and methods: In this study, six types of synthesized quinoline derivatives were used. Fast neutron removal cross-section, mean free path, half value layer and transmission number were theoretically determined by using GEometry ANd Tracking 4 and FLUktuierende KAskade simulation codes for neutron shielding. Neutron dose absorption rates were determined using the(241)Am-Be fast neutron source and the Canberra NP series portable BF(3)gas proportional neutron detector. Gamma radiation shielding parameters were determined by using WinXCom and PSY-X/PSD software. Additionally, the genotoxic potentials of the derivatives were assessed by using the Ames/Salmonellabacterial reversion assay. Results and conclusions: Neutron shielding parameters such as removal cross-section, mean free path, half value layer and transmission number were theoretically determined for fast neutrons. To determine neutron absorption capacity of quinoline derivatives, neutron absorption, experiments were conducted. In addition, gamma radiation shielding parameters were calculated such as the mean free path (MFP), mass attenuation coefficient (mu t), half value thickness layer (HVL) and effective atomic number (Zeff) in the energy range of 0.015-15 MeV. The results of the all quinoline derivatives have excellent fast neutron shielding power compared to ordinary concrete. In addition, all quinoline derivatives have been found to have the capacity to attenuate gamma radiation. Moreover, they absorb well in both types of radiation, do not cause secondary radiation, and they are genotoxically safe at the tested concentrations. This study has demonstrated that these products can be used as active ingredients for a drug to be developed against radiation.
AtıfScopus47WoS47OpenAlex52
İncele