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• Derleme MakaleYalnız künye2026Scopus SJRQ1/r/bayburt/12709
  The Potential Neuroprotective Role of Biotin in Neurorehabilitation: A Review

  Gunay, Esra; Gezmen-Karadag, Makbule

  Purpose of Review: Biotin is a water-soluble vitamin that mammals cannot synthesize and must obtain from the diet. Beyond its established role as a cofactor for biotin-dependent carboxylases, biotin has attracted neurological interest because intermediary metabolism, lipid handling, and myelin maintenance are biologically linked. This narrative review examines biotin across three distinct exposure contexts—nutritional adequacy, functional insufficiency, and pharmacological supplementation—and evaluates its putative relevance to neuroprotection and neurorecovery-oriented processes. Recent Findings: Dietary biotin intake is generally sufficient in mixed diets, and overt deficiency is uncommon; however, low diet quality, reduced bioavailability, and methodological limitations in status assessment may complicate interpretation of biotin sufficiency in clinical nutrition. No validated gold-standard biomarker is currently available. Experimental studies suggest that biotin may modulate pathways related to cellular bioenergetics, lipid metabolism, and myelin-associated processes, but these findings are predominantly preclinical and should not be interpreted as direct evidence of clinical efficacy. In progressive multiple sclerosis, high-dose biotin has been evaluated in human studies, including randomized trials, yet clinical results remain inconsistent and laboratory assay interference remains a relevant practical limitation. Summary: Current evidence does not support conflating adequate dietary biotin intake with pharmacological high-dose exposure. Although biotin remains mechanistically plausible in neuroenergetics and myelin-related disorders, its therapeutic relevance to neurorecovery remains uncertain. Better-designed studies are needed to refine exposure assessment, define dose–response relationships, and determine whether mechanistic signals translate into meaningful clinical benefit.

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• Kitap BölümüAçık Erişim2024/r/bayburt/11916
  Are Organic Foods Better for the Environment? Comparison of Environmental Costs of Organic and Conventional Foods

  Alkaya, Fatime; Günay, Esra; Turna, Hilal

  Biodiversity loss, soil and water pollution as well as global warming are among the most debated environmental issues worldwide. Conventional farming, which uses chemical pesticides and fertilizers, hormones and genetically modified products to obtain maximum yield per unit of land to feed the rapidly growing world population, is one of the main causes of these problems. As an alternative production system to conventional farming, organic farming has emerged to overcome environmental problems. The effectiveness of organic farming in addressing environmental issues has been debated for many years. In this chapter, the impact of organic foods on the environment is evaluated under the headings of biodiversity, soil and water quality, energy efficiency and climate change. The consensus drawn from studies is that organic farming is a more environmentally friendly production method compared to conventional farming. However, the heterogeneity of studies and environmental factors are influenced by many factors, making it difficult to reach a consensus.

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