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- MakaleAçık Erişim2024Scopus SJRQ2Eugenol alleviates the negative effects of experimental periodontitis and regulates adipokine hormones in rats
Sevinç Gül, Sema Nur; Özkal Eminoğlu, Didem; Tekçe, Emre; Bayraktar, Bülent; Güven, Leyla; Dilsiz, Alparslan; Yıldırım, Serkan; Sait, Ahmet
A chronic microbial infection that is mediated by the host's immune system is the cause of periodontal disease. As the world's population grows, phytotherapy is a therapeutic strategy that makes use of a renewable resource that can provide less costly medicines. This study aimed to investigate the therapeutic effects of eugenol administration on periodontitis by examining the effects of eugenol at different doses biochemically, histopathologically, and radiologically in rats with experimental periodontitis. Thirty-two Sprague Dawley male rats were divided into four groups: 1. the healthy control group (CG), 2. The experimental periodontitis group (PG), 3. The experimental periodontitis+10 mg/kg eugenol group (EG10), and 4. the experimental periodontitis+20 mg/kg eugenol group (EG20). Alveolar bone loss was measured using micro-CT imaging. The TNF-α, IL-6, leptin, asprosin, and apelin levels were analyzed in the serum samples of rats. Histological and immunohistochemical analyses were performed. The data were analyzed statistically. The serum TNF-α, IL-6, leptin, asprosin, and apelin levels were found to be statistically significantly lower in the eugenol-applied groups (EG10 and EG20) than in the PG (p < 0.05). There was a statistically significant difference in the TNF-α, IL-6, leptin, asprosin, and apelin levels between the EG10 and EG20 (p < 0.05). In the measurements made using micro-CT imaging, alveolar bone loss was found to be at the lowest FR1 level, and in histopathological analysis, the least inflammation was observed in the EG20. It was concluded that the application of 20 mg/kg eugenol in rats with experimental periodontitis was a safe dose, was beneficial in alleviating bone loss, and had a positive effect on the healing process.
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İncele - MakaleYalnız künye2020Investigation of the Effects of 8-Week Zumba and Step-Aerobic Exercises on Serum Leptin and Serum Ghrelin Hormone in Women
Temur, H. Bayram; Öge, Beyza
In this study, it was aimed to investigate the relationship between 8-week-old zumba and step-aerobic exercises with serum leptin and serum ghrelin. Semi-experimental method used in qualitative and quantitative research was used in the study. The experimental group consisted of 26 women who voluntarily participated in the study, with an average age of 41.40 +/- 9.90 years, who did not smoke or drink alcohol, do not exercise regularly, and lead a sedentary life. The experiment group was performed zumba and step-aerobic exercises with various choreographies for 3 weeks, 2 hours each, for 8 weeks. Blood samples were taken to determine the levels of hormone levels of the serum leptin and serum ghrelin three times before the exercise program, the 4th week of the exercise program and the end of the exercise program. Blood samples were taken in the morning hours after 8-10 hours of fasting. The data obtained as a result of the measurements were transferred to the computer environment. SPSS 20 package program was used in the analysis of these data. As a result of the analysis on the normal distribution of data, it was revealed that it showed a normal distribution. In the analysis of these data, Single Factor Variance Analysis (ANOVA) was used. Significance levels were evaluated according to p <0.05. As a result of the statistical analysis of the findings obtained in the research; The participants in the study were found to be statistically insignificant (p> 0.05) although there was a decrease in leptin and ghrelin levels. As a result, regular zumba and stepa-erobic exercises were found to cause a decrease in serum leptin and ghrelin levels in sedentary women, although not statistically significant.
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