Sürdürülebilir Kalkınma Amaçları

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Araştırmacılar(1)

• Bayraktar, Bülent

• MakaleAçık Erişim2026/r/bayburt/16799
  Annona muricata Leaf Extract Rebalances Systemic Redox Status and Modulates Neuroimmune, Microbial, and Functional Responses in CLP-Induced Septic Rats

  Ülker, U; Bayraktar, B; Alçığır, ME; Kızıl, S; Aydin, F; Kotan, GC; Yeni, M

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• MakaleAçık Erişim2026Scopus SJRQ1/r/bayburt/16798
  Pomegranate Peel Extract and Punicalagin Are Associated with Attenuated Intestinal Barrier Dysfunction, Oxidative Stress, and Multi-Organ Injury in a Rat CLP Model

  Yeni, M; Ürüşan, H; Bayraktar, B; Kotan, GC

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• MakaleAçık Erişim2026/r/bayburt/16796
  Dose-Related Effects of Cannabidiol on Inflammatory and Redox Responses, Bacterial Dissemination, and Multiorgan Injury in CLP-Induced Septic Rats

  Ülker, U; Bayraktar, B; Karan, T; Sinmez, ÇÇ; Tüfekçi, E; Bilici, E; Alpman, U; Kotan, GC; Yeni, M

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• MakaleAçık Erişim2026/r/bayburt/16794
  The Relationship of Cyberchondria, Negative Affect, and Anthropometric Indices with Heart-Rate Variability Among Health Sciences Students: A Psychophysiological Study of Digital Health-Information Behavior

  Erkılıç, TO; Bayraktar, B; Taşci, SÇ

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• MakaleAçık Erişim2026/r/bayburt/16077
  Tıp Fakültesi Öğrencilerinde Sınav Kaygısının Fizyolojik Belirtilerini Azaltmada Ardıç ve Kekik Uçucu Yağlarının Etkinliği

  Erkılıç, Tugçe Orkun; Bayraktar, Bülent; Bozok, Ümmü Gülşen; Ozcan, Gulbahar Boyuk

  Tıp öğrencileri, bilişsel ve akademik performansı olumsuz etkileyen sınav kaygısıyla mücadele etmektedir. Aromaterapi, farmakolojik tedavilere alternatif olarak popüler hale gelmektedir. Bu çalışma, ardıç ve kekik esansiyel yağlarının lisans öğrencilerinin sınav kaygısını psikofizyolojik olarak nasıl etkilediğini incelemektedir. Sınavlara giren öğrencilerde ardıç ve kekik aroması inhalasyonu asprosin, siklik guanozin monofosfat yanıt elementi bağlayıcı protein (CREB), kortizol ve sınav kaygısı üzerinde test edilmiştir. Yöntem: Tıp Fakültesi'nden 18-25 yaş arası 80 sağlıklı öğrencinin rastgele bir örneği, final sınavları sırasında toplanmıştır. Katılımcılar kendi kontrolleriydi ve aromaterapiden önce ve sonra tükürük alındı. Tükürük örnekleri ELISA kullanılarak Asprosin, CREB ve kortizol için test edildi. Kalp hızı, oksijen satürasyonu, sistolik basınç, diyastolik basınç ve vücut sıcaklığı aroma inhalasyonundan önce ve sonra izlenmiştir. Bulgular: Bu çalışmanın bulgularına göre, ardıç ve kekik aromaterapisinin tükürük ortalama Asprosin, CREB ve kortizol hormon düzeylerini artırmada etkili olduğu, en anlamlı düşüşün ise ardıç aromaterapisi alan gruplarda olduğu tespit edildi (p<0.001). Ardıç aromaterapi uygulaması Sistolik Kan Basıncı (SKB) ve Diyastolik Kan Basıncı (DKB)'yi etkilemiş (p<0.05) ancak Kalp Atım Hızı (KAH), Periferik Kapiller Oksijen Satürasyonu (SPO2) veya sıcaklığı etkilememiştir (p>0.05). Kekik aromaterapisi SBP, DBP, HR, SPO2 veya sıcaklığı etkilememiştir (p>0.05). Sonuç: Hafıza ve duyguları kontrol eden limbik sistem koku ile bağlantılıdır. Çalışmamız, koku inhalasyonunun sınav sırasında üniversite öğrencilerinde Asprosin, CREB, kortizol ve diğer fizyolojik göstergeleri etkilediğine dair özgün kanıtlar ortaya koymuştur ve sınav kaygısının giderilmesinde destekleyici bulgular sunmaktadır.

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  AtıfOpenAlex2

  İncele
• MakaleAçık Erişim2026/r/bayburt/16061
  Investigation of Structural Characteristics and Flock Management Practices of Sheep Breeding Farms: The Alaca District of Çorum Province Example

  Bayraktar, Bülent; Aydemir, Seyma; Kotan, Gökşad Cemil; Küçük, Gülben

  The aim of this study is to comprehensively examine the structural characteristics and herd management practices of sheep farms in Alaca district of Çorum province and to reveal their current status through a survey conducted on 130 sheep farms. The study revealed that the breeder population in the sector is concentrated in young (18-30 years old) and middle-aged (31-40 years old), with the younger generation actively participating in the sector. The vast majority of breeders view livestock farming as their primary source of income, with a predominant portion of their farms focusing on slaughter and sacrificial animal husbandry. While basic facilities such as resting areas, lighting, and ventilation are largely adequate, the lack of specialized enclosures necessary for modern herd management, such as sick animal pens (48.46%), milking parlors (86.92%), and shearing areas (100.00%), is striking. In terms of herd management practices, the most common age for first mating for females was 15 months. Rams are kept in the flock only during the breeding season in the majority of farms, and the most frequently used breeding method is reported to be free-breeding (pen breeding/pasture breeding). Underweight birth was identified as the primary cause of lamb mortality at 46.92%. Although the vast majority of farms regularly administer official vaccinations, only a small percentage conduct regular hoof checks and care, highlighting deficiencies in preventative herd protection practices. Furthermore, although almost all breeders use village communal pastures or highland pastures, 90.00% of breeders believe pastures are inadequate, primarily attributing this inadequacy to the small size of pasture areas.  In conclusion, despite its young and well-organized Sheep sector in Çorum, it exhibits significant deficiencies in modern herd management infrastructure and preventative herd protection practices, and faces a critical pasture availability problem. Therefore, to ensure sustainability and enhance competitiveness, it is crucial for local governments to encourage pasture improvement and forage production, as well as expand grant/support mechanisms for the development of modern shelter infrastructure.

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  AtıfOpenAlex1

  İncele
• MakaleAçık Erişim2026Scopus SJRQ3/r/bayburt/12784
  Neurobiological and psychological effects of reciting the Quran from the Mushaf

  Okur, Süheyb; Bayraktar, Bülent

  Background: This study aims to examine the acute neurobiological effects of reciting the Quran from the Mushaf on salivary BDNF, Apelin, and Cortisol levels and their relationship with emotional state. Methods: The study employed a randomized pre-test post-test control group design conducted in Türkiye. The sample consisted of 100 healthy theology students (50 females, 50 males) aged 18–25, proficient in reciting the Quran in accordance with Tajweed rules. Participants were randomly assigned to either the experimental group (reciting the first nine verses of Surah Al-Imran, n = 50) or the control group (standardized passive resting, n = 50). Salivary BDNF, apelin, and cortisol levels were measured using the ELISA technique before and after the intervention. Emotional states were assessed using the Mood Scale and the Psychological Well-being Scale. Results: The experimental group exhibited a statistically significant increase in mean salivary BDNF and apelin levels and a significant decrease in cortisol levels following recitation compared to the passive control group (p < 0.05). In terms of gender, no statistically significant differences were observed in biomarker responses (p >.05). Correlation analysis revealed a significant “biological reciprocity,” where cortisol showed a negative correlation with apelin (r = -0.436, p < 0.001) and BDNF, while correlating positively with negative emotions. Conclusions: Reciting the Quran aloud acts as a rapid psychophysiological intervention that downregulates the HPA axis (reduced cortisol) and upregulates neurotrophic factors (increased BDNF and apelin). These findings suggest that structured recitation functions as a restorative neuroplasticity practice, promoting biological stress resilience associated with psychological well-being.

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  AtıfScopus2·WoS3·OpenAlex2

  İncele
• MakaleYayıncıda açık erişim2026Scopus SJRQ2/r/bayburt/12744
  Metabolic, adipokine (irisin, spexin, visfatin), and ER stress (GRP78) responses in multiparous Brown Swiss cows: a multivariate approach across physiological stages and body condition scores

  Kotan, Gökşad Cemil; Aydemir, Şeyma; Bayraktar, Bülent

  This study investigated the responses of novel adipokines (irisin, spexin, visfatin), an endoplasmic reticulum (ER) stress marker (GRP78), and traditional metabolic parameters (non-esterified fatty acids (NEFAs), beta-hydroxybutyrate (BHBA), urea, albumin, globulin, total cholesterol) in 360 healthy Brown Swiss dairy cattle. The animals were categorized into 18 subgroups based on pregnancy stages (early, mid, dry), lactation stages (early, mid, late), and body condition scores (BCSs). Serum analyses were performed using ELISA and spectrophotometric methods. Interactions between physiological stages and BCS were highly significant for all measured parameters (p<0.001). Results showed that mean serum levels of spexin (ranging from 14.02 to 36.04 pg mL−1) and irisin increased as pregnancy and lactation progressed. Visfatin levels exhibited a significant increase specifically during the gestation period, peaking during the dry period (24.09 ng mL−1), and maintained a significant increasing trend as lactation progressed toward the late stage (Tables 2, 4). Conversely, GRP78 (peaking at 0.46 ng mL−1), NEFA (peaking at 0.52 mmol L−1), and urea levels peaked during the dry period and early lactation, subsequently decreasing as metabolic stability was achieved. Notably, during the dry period, stress markers rose despite declining albumin and globulin levels (p<0.05). These data indicate that the dry period and early lactation are the most critical phases for metabolic and cellular stress, characterized by lower spexin and elevated GRP78 and NEFA concentrations. The later rise in irisin and visfatin, while BHBA remained within physiological limits, confirms successful metabolic adaptation (p<0.001). In conclusion, the integrated evaluation of these novel biomarkers is anticipated to provide significant contributions to protective strategies and metabolic management in dairy cattle.

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• MakaleAçık Erişim2026Scopus SJRQ1/r/bayburt/12732
  Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs

  Kotan, Gökşad Cemil; Bayraktar, Bülent

  Background: This study investigated the effects of dietary graviola (Annona muricata L.) oil extract (GOE) (supplemented at 200, 400, and 600 mg/kg) on the growth performance and circadian rhythm profiles of adipokine, cardiac, and mitochondrial function biomarkers in 48 male Anatolian Merino lambs (2.5 months old). Methods: Lambs were assigned to a control group (G0) or supplementation groups (G200, G400, G600 mg/kg) for a 60-day trial (70 days total). The study was conducted under a 12-h light/12-h dark cycle to ensure controlled environmental conditions. To analyze circadian profiles, blood samples were collected on days 0, 15, 30, 45, and 60 at four time points (07:00, 13:00, 19:00, and 01:00). Serum levels of Apelin, cTnI, BMAL1, MOTS-c, and BMCP1 were measured by ELISA. Data were analyzed using GLM Multivariate analysis (p < 0.05). Results: Key findings showed the G400 dose resulted in the most effective linear increase in live weight and live weight gain by day 60, and had a significant overall effect on live weight (p < 0.05). The G200 dose significantly improved the feed conversion ratio (p < 0.05), while feed consumption was unaffected (p > 0.05). Regarding biomarkers on day 60, the G400 dose effectively modulated BMAL1, MOTS-c, and BMCP1 (peak at 19:00). The G600 dose yielded the best results for Apelin (peak at 19:00) and cTnI (peaks at 13:00 and 07:00). Conclusions: In conclusion, GOE at a dose of 400 mg/kg (G400) not only optimizes fattening performance in Anatolian Merino lambs but also supports metabolic homeostasis by modulating adipokine levels, cardiac function, and mitochondrial biogenesis processes in a manner consistent with the circadian rhythm. These findings demonstrate that the G400 dose is a safe and effective phytogenic strategy for improving animal health and production efficiency.

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• MakaleAçık Erişim2026Scopus SJRQ4/r/bayburt/12717
  Virucidal and antiviral activities of maca (Lepidium meyenii) root powder on three pathways of Norovirus as a foodborne pathogen; [Actividades viricidas y antivirales del polvo de raíz de maca (Lepidium meyenii) en tres vías del norovirus como patógeno transmitido por los alimentos]

  Korkmaz, Irem Omurtag; Korkmaz, Serol; Parmasiz, Ayse; Mavili, Seda; Bayraktar, Bülent; Sait, Ahmet; Keles, Aysen Gargili

  Vitamin C equivalency, the cytotoxicity on murine macrophage cells, and the virucidal and antiviral activities of maca (Lepidium meyenii) powder on murine norovirus (MNV) as a norovirus surrogate for human as a foodborne pathogen were studied. The antioxidant capacity of the maca was determined by MTT assay as vitamin C equivalency (VCEAC). The 50% cytotoxic concentration (CC50) was calculated with the linearity of maca concentrations-cell viability. The activities of maca against the virus was determined as the 50% tissue culture infective dose with Spearman–Karber method. The VCEAC of maca linearly increased with the concentration. The non-cytotoxic concentrations of maca were measured on murine macrophage with a CC50 of 5.77 mg/mL and a CC80 of 1.28 mg/mL. As maca reduced the virus titration based on contact time in the virucidal assay in several conditions, it did not significantly inhibit MNV on three infectivity pathways of host cell at non-cytotoxic concentrations of maca. The result of this first study presented that despite its ineffective in the treatment and prophylaxis of norovirus infection, maca might be an alternative food additive and preservative against human norovirus as an important foodborne pathogen causing outbreaks worldwide. © Los autores. Este artículo es publicado por la Rev Inv Vet Perú de la Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos. Este es un artículo de acceso abierto, distribuido bajo los términos de la licencia Creative Commons Atribución 4.0 Internacional (CC BY 4.0) [https://creativecommons.org/licenses/by/4.0/deed.es] que permite el uso, distribución y reproducción en cualquier medio, siempre que la obra original sea debidamente citada de su fuente original

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