Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Aksan, Mehmet Emrah(1)
- Aygan, Ashabil(1)
- Bayram, Sinan(1)
- Bülbül, Ali Savaş(1)
- Cömertpay, Sabahattin(1)
- Dereli, Ömer(1)
- Ekincioğlu, Yavuz(1)
- Karakaş Sarıkaya, Ebru(1)
- Kostak, Feyza(1)
- Kurian, Noble K(1)
- Narang, Urja(1)
- Orçan Çayır, İlayda(1)
- Pehlivanoğlu, Suray(1)
- Tahta, Beyhan(1)
- Türkmen, Merve Özcan(1)
- Uruş, Serhan(1)
- Çelik, Sultan(1)
Yayınlar
- MakaleYalnız künye2026Scopus SJRQ4Microwave assisted green synthesis of nano-sized biogenic silver in extract of Phlomis linearis: potential anticancer and antimicrobial activities
Orçan Çayır, İlayda; Tahta, Beyhan; Cömertpay, Sabahattin; Uruş, Serhan; Bülbül, Ali Savaş; Aygan, Ashabil; Aksan, Mehmet Emrah
Silver nanoparticles (AgNPs) are known for their significant anticancer and antimicrobial activities in the field of medicine. In the present study, AgNPs were synthesized using a microwave-assisted green synthesis process, in which Ag(I) ions were reduced by organic compounds extracted from the leaves and stems of Phlomis linearis, an endemic plant which acted as both reducing and stabilizing agents. Although various species of the Phlomis genus have been studied in the literature, the synthesis of the nano-sized biogenic silver with reducing Ag(I) in the extract of the endemic plant P. linearis is reported here for the first study time, along with the evaluations of its bioactive properties. The obtained AgNPs were characterized by optical, structural, morphological, etc. techniques such as Ultraviolet–visible spectroscopy (UV–Vis.), Fourier-Transform Infrared Spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), transmission electron microscopy (TEM), dynamic light scattering (DLS), and photoluminescence (PL). Gas chromatography − mass spectrometry (GC–MS) and FT-IR techniques were used in order to evaluate the biochemical-reduction mechanism. When their antimicrobial activities were determined by the well diffusion method on six bacterial strains, the results showed that P. linearis exhibited antimicrobial activity against all tested bacteria. Additionally, the investigation of the anticancer activity of the particles by using the MTS method on a breast cancer cell line (MCF-7) and a healthy human cell population (human umbilical vein endothelial cells [HUVEC]) revealed that our AgNPs were more cytotoxic toward the cancerous cells compared to the non-cancerous ones (p < 0.001).
- MakaleAçık Erişim2025Scopus SJRQ1Anticancer (cytotoxic, anticlonogenic, antimetastatic, immunomodulatory actions) properties of 3,5-dibromosalicylaldehyde against glioblastoma cells and DFT analyses (FT-IR, Raman, NMR, UV) as well as a molecular docking study
Karakaş Sarıkaya, Ebru; Pehlivanoğlu, Suray; Türkmen, Merve Özcan; Ekincioğlu, Yavuz; Kostak, Feyza; Çelik, Sultan; Dereli, Ömer
Background Information: The primary objectives of this study were to characterize 3,5-dibromosalicylaldehyde (3,5-DBSA) and, investigate its antiproliferative, antimetastatic, cytotoxic, and immunoregulatory properties. NMR, Raman, UV, and FT-IR spectroscopies were used to characterize 3,5-DBSA. Potential conformations of 3,5-DBSA were evaluated using Spartan's MMFF method. Geometry optimization calculations using Gaussian software calculated conformation energy values. Results: Subsequently, Raman, FT-IR, UV (ethanol) and NMR (DMSO) parameters were calculated. The experimental spectrum was compared to theoretical spectroscopic data. The present investigation investigated 3,5-DBSA's anticancer properties; therefore, docking was done once the stable structure had been identified. Conclusion: Identifying stable structure is crucial to molecular docking studies. In order to identify the mechanism by which 3,5-DBSA binds to PI3K as a therapeutic target, molecular docking was utilized. This work is the first to show that 3,5-DBSA is cytotoxic, anticlonogenic, antimetastatic, and immunomodulatory in glioblastoma cell line U87MG compared to healthy fibroblast L929 cells. Cytotoxicity and anti-clonogenicity studies investigated 3,5-DBSA's antiproliferative activities, whereas wound healing assays assessed cell migration. The immunomodulatory effects of 3,5-DBSA in glioblastoma were assessed by measuring Netrin-1 and IL-6 protein levels. According to our findings, 3,5-DBSA may treat glioblastoma. Significance: This work analyzes 3,5-DBSA's conformational search, characterization, molecular docking, and structural and anticancer properties.
- Kitap BölümüAçık Erişim2023Enigmatic secondary metabolites: Microbial melanins and their applications
Narang, Urja; Kurian, Noble K; Bayram, Sinan
Melanin is a biomacromolecule found in all kingdoms of life that ranges from dark brown to black pigment. Eumelanin, allomelanin, neuromelanin, and pheomelanin are all types of melanin. They possess a wide range of bioactive properties, including antioxidant, radioprotective, antimicrobial, antiviral, antiinflammatory, antiproliferative, and photoprotective properties. Melanin has anticancer and antimicrobial properties that make it useful in pharmacology and medicine. In addition, it has applications in cosmetics; to mimic the natural process of these compounds in the skin, many manufacturers have embraced the use of melanin in sunscreens. Furthermore, due to the absorption of ultraviolet rays, mixed electronic-ionic conductivity, and hydration state-dependent electrical properties of melanin, it is used in organic electronics such as solar cells, batteries, and biosensors. This review examines the various functions and applications of this biological pigment, as well as its distinct physicochemical, chemical, bioactive, and anticorrosive properties.
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