Sürdürülebilir Kalkınma Amaçları

• 1

Yazarlar

• Agar, Guleray(2)
• Alpsoy, Lokman(2)
• Ceker, Selcuk(2)
• Kizil, Hamit Emre(2)
• Anar, Mustafa(1)
• Asian, Ali(1)
• Aslan, Ali(1)
• Gulluce, Medine(1)
• Orhan, Furkan(1)

• MakaleAçık Erişim2015Scopus SJRQ2/r/bayburt/12465
  Genotoxic and antigenotoxic potentials of two Usnea species

  Ceker, Selcuk; Orhan, Furkan; Kizil, Hamit Emre; Alpsoy, Lokman; Gulluce, Medine; Aslan, Ali; Agar, Guleray

  For ages, lichens have long been investigated popularly for biological roles, mainly antitumor, antimicrobial and antioxidant activities. Many positive results were obtained in these previous research. Thus, in this study, we aimed to determine whether extracts of Usnea articulata (UAE) and Usnea filipendula (UFE) possessing a protection against aflatoxin B1(AFB1)-induced genotoxic and oxidative damage. The results of our studies showed that 5 μM concentrations of AFB1increased the frequencies of sister chromatid exchange (SCE) and the level of malondialdehyde (MDA) and decreased the activities of superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx). However, when 5, 10 and 20 µg/mL concentrations of UAE and UFE was added to AFB1, the frequencies of SCE and MDA level were decreased and SOD, GSH and GPx level were increased. The Ames (Salmonella typhimurium TA1535, TA1537) and WP2 (Escherichia coli) test systems carried out evinced that UAE and UFE possess any mutagenicity, but have antimutagenic effects. Consequently, the results of this experiment have clearly shown that UAE and UFE have strong antioxidative and antigenotoxic effects that are associated with its antioxidant nature. A detailed study can be performed to determine the antioxidant properties of each compound that will extend the use of lichen extracts in food and pharmacy industries.

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  AtıfScopus16·WoS13·OpenAlex14

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• MakaleYalnız künye2015Scopus SJRQ3/r/bayburt/12449
  Determination of antigenotoxic effects of four lichen species by using human lymphocytes

  Anar, Mustafa; Asian, Ali; Ceker, Selcuk; Kizil, Hamit Emre; Alpsoy, Lokman; Agar, Guleray

  In this study, the geno-toxic and antigeno-toxic properties of the total extracts of four lichen species were investigated by using human lymphocytes. We obtained total extracts from R farinacea, X. parietina, U. articulataand U. filipendula lichen species. The results of our studies showed that 5 μM concentrations of AFB1 changed the frequencies of micronucleus (MN) and malondialdehyde (MDA) levels, as well as superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx) activities. When 5,10 and 20 μg/ml concentrations of total extract were added to AFB1, the frequencies of MN and MDA levels were decreased, and SOD, GSH and GPx levels were increased. Consequently, our findings show that four lichen total extracts have strong antigenotoxic properties against aflatoxin Bi.

  AtıfScopus3

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